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Conserved domains on  [gi|134288853|ref|NP_035058|]
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neurogenic locus notch homolog protein 2 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1852-2067 5.21e-44

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.82  E-value: 5.21e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1852 AEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILI 1931
Cdd:COG0666    61 AALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1932 RNRVtDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKE 2011
Cdd:COG0666   141 EAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG 219

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 134288853 2012 ETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYN 2067
Cdd:COG0666   220 KTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1661-1742 9.00e-43

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


:

Pssm-ID: 411986  Cd Length: 82  Bit Score: 151.45  E-value: 9.00e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1661 LSYPLVSVFSELESPRNAQLLYLLAVAVVIILFFILLGVIMAKRKRKHGFLWLPEGFTLRRDSSNHKRREPVGQDAVGLK 1740
Cdd:cd21703     1 LPYPLVSVTSEPLKETKFNLLYLLAVAVAIILLILLLGVLVAKRKRKHGPLWFPEGFILNKENSNRKRREPVGQDAVGMK 80


                  ..
gi 134288853 1741 NL 1742
Cdd:cd21703    81 NL 82
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1539-1594 1.18e-24

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


:

Pssm-ID: 462014  Cd Length: 56  Bit Score: 98.74  E-value: 1.18e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 134288853  1539 PENLAEGTLIIVVLLPPEQLLQDSRSFLRALGTLLHTNLRIKQDSQGALMVYPYFG 1594
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1620-1675 1.12e-12

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


:

Pssm-ID: 462229  Cd Length: 59  Bit Score: 64.60  E-value: 1.12e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 134288853  1620 VIGSKIFLEIDNRQCVQDSDQCFKNTDAAAALLASHAIQGTLS--YPLVSVFSELESP 1675
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSSDECFSTAQSAADFLAALAAKGGLDlpYPIKEVRSEPPPP 58
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 182-218 1.99e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 57.65  E-value: 1.99e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  182 DINECDIPGRCQHGGTCLNLPGSYRCQCPQGFTGQHC 218
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1423-1456 1.36e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 55.23  E-value: 1.36e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 134288853  1423 ATCQSQYCADKARDGICDEACNSHACQWDGGDCS 1456
Cdd:pfam00066    2 PNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1025-1061 6.93e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.41  E-value: 6.93e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853 1025 DINECSS-NPCLNAGTCVDGLGTYRCICPLGYTGKNCQ 1061
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 873-909 1.69e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 1.69e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  873 DVDECISK-PCMNNGVCHNTQGSYVCECPPGFSGMDCE 909
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1501-1534 2.46e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 2.46e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 134288853  1501 KTCKYDkYCADHFKDNHCDQGCNSEECGWDGLDC 1534
Cdd:pfam00066    2 PNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 949-985 3.42e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 3.42e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  949 DMNECLSE-PCKNGGTCSDYVNSYTCTCPAGFHGVHCE 985
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1225-1262 3.52e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 3.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853 1225 NIDECAGGPHCLNGGQCVDRIGGYTCRCLPGFAGERCE 1262
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 757-793 8.49e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 8.49e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  757 DKNECLS-NPCQNGGTCNNLVNGYRCTCKKGFKGYNCQ 793
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1151-1185 1.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.22e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 134288853 1151 DECAS-NPCQHGATCNDFIGGYRCECVPGYQGVNCE 1185
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 456-492 1.29e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.29e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  456 DINECHS-DPCQNDATCLDKIGGFTCLCMPGFKGVHCE 492
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 495-530 2.17e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 2.17e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  495 VNECQS-NPCVNNGQCVDKVNRFQCLCPPGFTGPVCQ 530
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 911-947 3.66e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.66e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  911 DINDCL-ANPCQNGGSCVDHVNTFSCQCHPGFIGDKCQ 947
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 415-454 7.40e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 7.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 134288853  415 DVDECAManSNPCEHAGKCVNTDGAFHCECLKGYAGPRCE 454
Cdd:cd00054     1 DIDECAS--GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 987-1022 1.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 1.03e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  987 NIDECTESS-CFNGGTCVDGINSFSCLCPVGFTGPFC 1022
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 608-643 1.10e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 1.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  608 IDECYS-SPCLNDGRCIDLVNGYQCNCQPGTSGLNCE 643
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1188-1223 1.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853 1188 VDECQ-NQPCQNGGTCIDLVNHFKCSCPPGTRGLLCE 1223
Cdd:cd00054     2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 682-717 1.43e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.43e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  682 DIDECAS-NPCRKGATCINDVNGFRCICPEGPHHPSC 717
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 795-831 2.16e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.16e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  795 NIDECAS-NPCLNQGTCFDDVSGYTCHCMLPYTGKNCQ 831
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 532-567 4.41e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 4.41e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  532 DIDDCSST-PCLNGAKCIDHPNGYECQCATGFTGILC 567
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1463-1497 5.60e-06

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 44.83  E-value: 5.60e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 134288853  1463 WANCTSTlRCWEYINN-QCDEQCNTAECLFDNFECQ 1497
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNgVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 298-335 6.46e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 6.46e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  298 DVDECLlQPNACQNGGTCTNRNGGYGCVCVNGWSGDDC 335
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 2069-2424 2.24e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2069 TPSPPGTvltSALSPVLCGPnrsflslkhTPMGKKARRPNTKSTMPTSLPNLAKEAKDAKGSRRKKCLNEKVQLSESS-- 2146
Cdd:PHA03247 2615 SPLPPDT---HAPDPPPPSP---------SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPqr 2682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2147 -------VTLSPVDSLESPHTYVSDATSSPMITSPGiLQASPTPLLAAAAPAAPVHTQHALSFSNlhdmQPLAPGASTVL 2219
Cdd:PHA03247 2683 prrraarPTVGSLTSLADPPPPPPTPEPAPHALVSA-TPLPPGPAAARQASPALPAAPAPPAVPA----GPATPGGPARP 2757

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2220 PSVSQLLSHHHIAPPGSSSAGSLGRLHPVPVPADWMNRVEMNETQYSEMFGMVLAPAEGAHPGIAAPQS-RPPEGKHMST 2298
Cdd:PHA03247 2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGpLPPPTSAQPT 2837

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2299 QREPLPPIVTFQLIPKGSIA------------QAAGAPQTQSSCP------PAVAGPLPSMYQIP---EMPRLPSVAFPP 2357
Cdd:PHA03247 2838 APPPPPGPPPPSLPLGGSVApggdvrrrppsrSPAAKPAAPARPPvrrlarPAVSRSTESFALPPdqpERPPQPQAPPPP 2917

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134288853 2358 TMMPQQEGQVAQTIVPTYHPFPASvgkyPTPPSQHSYASSNA--AERTPSHGGHLQGEHP---YLTPSPESP 2424
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQP----PLAPTTDPAGAGEPsgAVPQPWLGALVPGRVAvprFRVPQPAPS 2985
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 260-296 4.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 4.05e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  260 NIDDC-PNHKCQNGGVCVDGVNTYNCRCPPQWTGQFCT 296
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 645-679 1.72e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.72e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  645 NFDDCAS-NPCM-HGVCVDGINRYSCVCSPGFTGQRC 679
Cdd:cd00054     1 DIDECASgNPCQnGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 570-604 1.48e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  570 NIDNCD-PDPC-HHGQCQDGIDSYTCICNPGYMGAIC 604
Cdd:cd00054     1 DIDECAsGNPCqNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1264-1302 1.66e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 134288853 1264 DINECLS-NPCSSEGSldCVQLKNNYNCICRSAFTGRHCE 1302
Cdd:cd00054     1 DIDECASgNPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1117-1147 1.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.75e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 134288853 1117 EHLCQHSGICINAGNTHHCQCPLGYTGSYCE 1147
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1312-1343 1.87e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.87e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 134288853 1312 PCLNGGTCavaSNMPDGFICRCPPGFSGARCQ 1343
Cdd:cd00054    10 PCQNGGTC---VNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 109-143 8.29e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 8.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 134288853  109 CFVSRPCQNGGTCHMLsRDTYECTCQVGFTGKQCQ 143
Cdd:cd00054     5 CASGNPCQNGGTCVNT-VGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1852-2067 5.21e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.82  E-value: 5.21e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1852 AEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILI 1931
Cdd:COG0666    61 AALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1932 RNRVtDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKE 2011
Cdd:COG0666   141 EAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG 219

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 134288853 2012 ETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYN 2067
Cdd:COG0666   220 KTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1661-1742 9.00e-43

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 151.45  E-value: 9.00e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1661 LSYPLVSVFSELESPRNAQLLYLLAVAVVIILFFILLGVIMAKRKRKHGFLWLPEGFTLRRDSSNHKRREPVGQDAVGLK 1740
Cdd:cd21703     1 LPYPLVSVTSEPLKETKFNLLYLLAVAVAIILLILLLGVLVAKRKRKHGPLWFPEGFILNKENSNRKRREPVGQDAVGMK 80


                  ..
gi 134288853 1741 NL 1742
Cdd:cd21703    81 NL 82
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1539-1594 1.18e-24

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 98.74  E-value: 1.18e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 134288853  1539 PENLAEGTLIIVVLLPPEQLLQDSRSFLRALGTLLHTNLRIKQDSQGALMVYPYFG 1594
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1949-2041 1.34e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 1.34e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853  1949 LILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNgANRDMQDNKeETPLFLAAREGSYEAAK 2028
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 134288853  2029 ILLDHFANRDITD 2041
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1821-2031 1.60e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.91  E-value: 1.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1821 DVNVRGPDGCTPLMlASLRGGSSDlsdededaedssANIITDLVYQGASLQAqTDRTGEMALHLAARYSRADAA--KRLL 1898
Cdd:PHA03095  109 DVNAKDKVGRTPLH-VYLSGFNIN------------PKVIRLLLRKGADVNA-LDLYGMTPLAVLLKSRNANVEllRLLI 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1899 DAGADANAQDNMGRCPLH--AAVAADAQGVFQILIRnRVTDLDARMNDGTTPLILAARLAV--EGMVAELINCQADVNAV 1974
Cdd:PHA03095  175 DAGADVYAVDDRFRSLLHhhLQSFKPRARIVRELIR-AGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINAR 253

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 134288853 1975 DDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILL 2031
Cdd:PHA03095  254 NRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1620-1675 1.12e-12

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 64.60  E-value: 1.12e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 134288853  1620 VIGSKIFLEIDNRQCVQDSDQCFKNTDAAAALLASHAIQGTLS--YPLVSVFSELESP 1675
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSSDECFSTAQSAADFLAALAAKGGLDlpYPIKEVRSEPPPP 58
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 182-218 1.99e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 57.65  E-value: 1.99e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  182 DINECDIPGRCQHGGTCLNLPGSYRCQCPQGFTGQHC 218
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
182-219 1.35e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 55.33  E-value: 1.35e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    182 DINECDIPGRCQHGGTCLNLPGSYRCQCPQGFT-GQHCD 219
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1423-1456 1.36e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 55.23  E-value: 1.36e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 134288853  1423 ATCQSQYCADKARDGICDEACNSHACQWDGGDCS 1456
Cdd:pfam00066    2 PNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1421-1455 3.80e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 53.87  E-value: 3.80e-09
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 134288853   1421 PPATCQSQYCADKARDGICDEACNSHACQWDGGDC 1455
Cdd:smart00004    4 PWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1025-1061 6.93e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.41  E-value: 6.93e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853 1025 DINECSS-NPCLNAGTCVDGLGTYRCICPLGYTGKNCQ 1061
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 873-909 1.69e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 1.69e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  873 DVDECISK-PCMNNGVCHNTQGSYVCECPPGFSGMDCE 909
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1501-1534 2.46e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 2.46e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 134288853  1501 KTCKYDkYCADHFKDNHCDQGCNSEECGWDGLDC 1534
Cdd:pfam00066    2 PNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 949-985 3.42e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 3.42e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  949 DMNECLSE-PCKNGGTCSDYVNSYTCTCPAGFHGVHCE 985
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1225-1262 3.52e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 3.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853 1225 NIDECAGGPHCLNGGQCVDRIGGYTCRCLPGFAGERCE 1262
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
873-909 4.10e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 51.09  E-value: 4.10e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    873 DVDECISK-PCMNNGVCHNTQGSYVCECPPGFS-GMDCE 909
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 757-793 8.49e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 8.49e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  757 DKNECLS-NPCQNGGTCNNLVNGYRCTCKKGFKGYNCQ 793
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1151-1185 1.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.22e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 134288853 1151 DECAS-NPCQHGATCNDFIGGYRCECVPGYQGVNCE 1185
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 456-492 1.29e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.29e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  456 DINECHS-DPCQNDATCLDKIGGFTCLCMPGFKGVHCE 492
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1025-1061 1.89e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 1.89e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853   1025 DINECSS-NPCLNAGTCVDGLGTYRCICPLGYT-GKNCQ 1061
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1496-1534 2.01e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 49.25  E-value: 2.01e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853   1496 CQRNSKTCKyDKYCADHFKDNHCDQGCNSEECGWDGLDC 1534
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 495-530 2.17e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 2.17e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  495 VNECQS-NPCVNNGQCVDKVNRFQCLCPPGFTGPVCQ 530
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 911-947 3.66e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.66e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  911 DINDCL-ANPCQNGGSCVDHVNTFSCQCHPGFIGDKCQ 947
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1225-1262 4.38e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 4.38e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853   1225 NIDECAGGPHCLNGGQCVDRIGGYTCRCLPGF-AGERCE 1262
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 415-454 7.40e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 7.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 134288853  415 DVDECAManSNPCEHAGKCVNTDGAFHCECLKGYAGPRCE 454
Cdd:cd00054     1 DIDECAS--GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1151-1185 8.71e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 8.71e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 134288853   1151 DECAS-NPCQHGATCNDFIGGYRCECVPGYQ-GVNCE 1185
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 987-1022 1.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 1.03e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  987 NIDECTESS-CFNGGTCVDGINSFSCLCPVGFTGPFC 1022
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 608-643 1.10e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 1.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  608 IDECYS-SPCLNDGRCIDLVNGYQCNCQPGTSGLNCE 643
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1188-1223 1.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853 1188 VDECQ-NQPCQNGGTCIDLVNHFKCSCPPGTRGLLCE 1223
Cdd:cd00054     2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
949-985 1.24e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.24e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    949 DMNECLSE-PCKNGGTCSDYVNSYTCTCPAGFH-GVHCE 985
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 682-717 1.43e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.43e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  682 DIDECAS-NPCRKGATCINDVNGFRCICPEGPHHPSC 717
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
757-793 1.46e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.46e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    757 DKNECLS-NPCQNGGTCNNLVNGYRCTCKKGFK-GYNCQ 793
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1873-2047 2.11e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 53.09  E-value: 2.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1873 QTDRTGEMALHLAARYSRADAAKRLLD-AGADANAQDNMGRCPLHAAVAADAQGVFQILIRNrVTDL-----DARMNDGT 1946
Cdd:cd22192    12 QQKRISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEA-APELvnepmTSDLYQGE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1947 TPLILAARLAVEGMVAELINCQADVN--------------AVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEE 2012
Cdd:cd22192    91 TALHIAVVNQNLNLVRELIARGADVVspratgtffrpgpkNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 134288853 2013 TPLFLAAREGSYEAAKILLDHFANRDITDH---MDRLP 2047
Cdd:cd22192   171 TVLHILVLQPNKTFACQMYDLILSYDKEDDlqpLDLVP 208
EGF_CA smart00179
Calcium-binding EGF-like domain;
456-492 2.15e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 2.15e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    456 DINECHS-DPCQNDATCLDKIGGFTCLCMPGFK-GVHCE 492
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 795-831 2.16e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.16e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  795 NIDECAS-NPCLNQGTCFDDVSGYTCHCMLPYTGKNCQ 831
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
682-711 4.26e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.26e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 134288853    682 DIDECAS-NPCRKGATCINDVNGFRCICPEG 711
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 532-567 4.41e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 4.41e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  532 DIDDCSST-PCLNGAKCIDHPNGYECQCATGFTGILC 567
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1463-1497 5.60e-06

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 44.83  E-value: 5.60e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 134288853  1463 WANCTSTlRCWEYINN-QCDEQCNTAECLFDNFECQ 1497
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNgVCDEECNNAECLWDGGDCS 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
415-454 6.25e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 6.25e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 134288853    415 DVDECAManSNPCEHAGKCVNTDGAFHCECLKGY-AGPRCE 454
Cdd:smart00179    1 DIDECAS--GNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 298-335 6.46e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 6.46e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  298 DVDECLlQPNACQNGGTCTNRNGGYGCVCVNGWSGDDC 335
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
494-530 8.56e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 8.56e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    494 EVNECQS-NPCVNNGQCVDKVNRFQCLCPPGFT-GPVCQ 530
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1187-1223 1.06e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.06e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853   1187 EVDECQ-NQPCQNGGTCIDLVNHFKCSCPPG-TRGLLCE 1223
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1029-1059 1.19e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.91  E-value: 1.19e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853  1029 CSSNPCLNAGTCVDGLGTYRCICPLGYTGKN 1059
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
608-643 1.33e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.33e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134288853    608 IDECYS-SPCLNDGRCIDLVNGYQCNCQPG-TSGLNCE 643
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1459-1496 1.50e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 43.85  E-value: 1.50e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853   1459 MEDPWANCTStLRCWEYINN-QCDEQCNTAECLFDNFEC 1496
Cdd:smart00004    1 PQDPWSRCED-AQCWDKFGDgVCDEECNNAECLWDGGDC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
911-947 1.59e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.59e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    911 DINDCL-ANPCQNGGSCVDHVNTFSCQCHPGFI-GDKCQ 947
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2069-2424 2.24e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2069 TPSPPGTvltSALSPVLCGPnrsflslkhTPMGKKARRPNTKSTMPTSLPNLAKEAKDAKGSRRKKCLNEKVQLSESS-- 2146
Cdd:PHA03247 2615 SPLPPDT---HAPDPPPPSP---------SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPqr 2682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2147 -------VTLSPVDSLESPHTYVSDATSSPMITSPGiLQASPTPLLAAAAPAAPVHTQHALSFSNlhdmQPLAPGASTVL 2219
Cdd:PHA03247 2683 prrraarPTVGSLTSLADPPPPPPTPEPAPHALVSA-TPLPPGPAAARQASPALPAAPAPPAVPA----GPATPGGPARP 2757

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2220 PSVSQLLSHHHIAPPGSSSAGSLGRLHPVPVPADWMNRVEMNETQYSEMFGMVLAPAEGAHPGIAAPQS-RPPEGKHMST 2298
Cdd:PHA03247 2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGpLPPPTSAQPT 2837

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2299 QREPLPPIVTFQLIPKGSIA------------QAAGAPQTQSSCP------PAVAGPLPSMYQIP---EMPRLPSVAFPP 2357
Cdd:PHA03247 2838 APPPPPGPPPPSLPLGGSVApggdvrrrppsrSPAAKPAAPARPPvrrlarPAVSRSTESFALPPdqpERPPQPQAPPPP 2917

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134288853 2358 TMMPQQEGQVAQTIVPTYHPFPASvgkyPTPPSQHSYASSNA--AERTPSHGGHLQGEHP---YLTPSPESP 2424
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQP----PLAPTTDPAGAGEPsgAVPQPWLGALVPGRVAvprFRVPQPAPS 2985
EGF_CA smart00179
Calcium-binding EGF-like domain;
987-1022 2.86e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.86e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134288853    987 NIDECTESS-CFNGGTCVDGINSFSCLCPVGFT-GPFC 1022
Cdd:smart00179    1 DIDECASGNpCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 260-296 4.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 4.05e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  260 NIDDC-PNHKCQNGGVCVDGVNTYNCRCPPQWTGQFCT 296
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2108-2424 4.24e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.00  E-value: 4.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853  2108 NTKSTMPtSLPNLAKEAKDAKGSRRKKCLN-EKVQLSESSVTLSPVDSLESPHTYVSDAT-----------SSPMITSPG 2175
Cdd:pfam03154  140 DNRSTSP-SIPSPQDNESDSDSSAQQQILQtQPPVLQAQSGAASPPSPPPPGTTQAATAGptpsapsvppqGSPATSQPP 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853  2176 ILQASPTPLLAAAAPAAPVHTQHALS-FSNLHDMQPLAPgASTVLPSVSQLLSHHHIAPPGSSS--AGSLGRLHPVPvpa 2252
Cdd:pfam03154  219 NQTQSTAAPHTLIQQTPTLHPQRLPSpHPPLQPMTQPPP-PSQVSPQPLPQPSLHGQMPPMPHSlqTGPSHMQHPVP--- 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853  2253 dwmnrvemnetqySEMFGMVLAPAEGAHPgiAAPQSRPPegkHMSTQREPLPPivtfqlipkgsiaqaaGAPQTQSSCPP 2332
Cdd:pfam03154  295 -------------PQPFPLTPQSSQSQVP--PGPSPAAP---GQSQQRIHTPP----------------SQSQLQSQQPP 340

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853  2333 AvAGPL-PSMYQIPEMPRLPSVAFPPTMMPQQEGQVAQTIVPTYHPFPASVgkyPTPPSQHSYASSNAAERTPSHGGHLQ 2411
Cdd:pfam03154  341 R-EQPLpPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNL---PPPPALKPLSSLSTHHPPSAHPPPLQ 416

                          330
                   ....*....|....*
gi 134288853  2412 --GEHPYLTPSPESP 2424
Cdd:pfam03154  417 lmPQSQQLPPPPAQP 431
EGF_CA smart00179
Calcium-binding EGF-like domain;
532-563 5.36e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 5.36e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 134288853    532 DIDDCSST-PCLNGAKCIDHPNGYECQCATGFT 563
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
795-831 6.79e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 6.79e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    795 NIDECAS-NPCLNQGTCFDDVSGYTCHCMLPYT-GKNCQ 831
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
873-902 9.76e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 9.76e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134288853   873 DVDECIS--KPCMNNGVCHNTQGSYVCECPPG 902
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 536-564 1.10e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 1.10e-04
                           10        20
                   ....*....|....*....|....*....
gi 134288853   536 CSSTPCLNGAKCIDHPNGYECQCATGFTG 564
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
298-335 1.34e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.34e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    298 DVDECLlQPNACQNGGTCTNRNGGYGCVCVNGWS-GDDC 335
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 645-679 1.72e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.72e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  645 NFDDCAS-NPCM-HGVCVDGINRYSCVCSPGFTGQRC 679
Cdd:cd00054     1 DIDECASgNPCQnGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1153-1183 3.78e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 3.78e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853  1153 CASNPCQHGATCNDFIGGYRCECVPGYQGVN 1183
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 189-217 4.17e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 4.17e-04
                           10        20
                   ....*....|....*....|....*....
gi 134288853   189 PGRCQHGGTCLNLPGSYRCQCPQGFTGQH 217
Cdd:pfam00008    3 PNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 761-789 5.12e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 5.12e-04
                           10        20
                   ....*....|....*....|....*....
gi 134288853   761 CLSNPCQNGGTCNNLVNGYRCTCKKGFKG 789
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 498-527 5.12e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 5.12e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 134288853   498 CQSNPCVNNGQCVDKVNRFQCLCPPGFTGP 527
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA pfam07645
Calcium-binding EGF domain;
682-711 6.62e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 6.62e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134288853   682 DIDECAS--NPCRKGATCINDVNGFRCICPEG 711
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 953-983 7.02e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.02e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853   953 CLSEPCKNGGTCSDYVNSYTCTCPAGFHGVH 983
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 799-829 7.67e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.67e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853   799 CASNPCLNQGTCFDDVSGYTCHCMLPYTGKN 829
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 915-944 7.89e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.89e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 134288853   915 CLANPCQNGGSCVDHVNTFSCQCHPGFIGD 944
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 570-604 1.48e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  570 NIDNCD-PDPC-HHGQCQDGIDSYTCICNPGYMGAIC 604
Cdd:cd00054     1 DIDECAsGNPCqNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1264-1302 1.66e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 134288853 1264 DINECLS-NPCSSEGSldCVQLKNNYNCICRSAFTGRHCE 1302
Cdd:cd00054     1 DIDECASgNPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1117-1147 1.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.75e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 134288853 1117 EHLCQHSGICINAGNTHHCQCPLGYTGSYCE 1147
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1312-1343 1.87e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.87e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 134288853 1312 PCLNGGTCavaSNMPDGFICRCPPGFSGARCQ 1343
Cdd:cd00054    10 PCQNGGTC---VNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1191-1219 2.33e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.33e-03
                           10        20
                   ....*....|....*....|....*....
gi 134288853  1191 CQNQPCQNGGTCIDLVNHFKCSCPPGTRG 1219
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA pfam07645
Calcium-binding EGF domain;
298-329 2.38e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 2.38e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134288853   298 DVDECLLQPNACQNGGTCTNRNGGYGCVCVNG 329
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 460-490 2.67e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.67e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853   460 CHSDPCQNDATCLDKIGGFTCLCMPGFKGVH 490
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
260-296 2.74e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.74e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    260 NIDDC-PNHKCQNGGVCVDGVNTYNCRCPPQWT-GQFCT 296
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1226-1255 4.04e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 4.04e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853  1226 IDECAGGPH-CLNGGQCVDRIGGYTCRCLPG 1255
Cdd:pfam07645    2 VDECATGTHnCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 611-641 4.54e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.54e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853   611 CYSSPCLNDGRCIDLVNGYQCNCQPGTSGLN 641
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 423-452 5.98e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 5.98e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 134288853   423 NSNPCEHAGKCVNTDGAFHCECLKGYAGPR 452
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 991-1021 6.16e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 6.16e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853   991 CTESSCFNGGTCVDGINSFSCLCPVGFTGPF 1021
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
645-679 7.12e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.12e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134288853    645 NFDDCAS-NPCMHG-VCVDGINRYSCVCSPGFT-GQRC 679
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 109-143 8.29e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 8.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 134288853  109 CFVSRPCQNGGTCHMLsRDTYECTCQVGFTGKQCQ 143
Cdd:cd00054     5 CASGNPCQNGGTCVNT-VGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1852-2067 5.21e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.82  E-value: 5.21e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1852 AEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILI 1931
Cdd:COG0666    61 AALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1932 RNRVtDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKE 2011
Cdd:COG0666   141 EAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG 219

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 134288853 2012 ETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYN 2067
Cdd:COG0666   220 KTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1867-2067 3.80e-43

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 160.50  E-value: 3.80e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1867 GASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVtDLDARMNDGT 1946
Cdd:COG0666    43 ALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGE 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1947 TPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEA 2026
Cdd:COG0666   122 TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 134288853 2027 AKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYN 2067
Cdd:COG0666   202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1661-1742 9.00e-43

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 151.45  E-value: 9.00e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1661 LSYPLVSVFSELESPRNAQLLYLLAVAVVIILFFILLGVIMAKRKRKHGFLWLPEGFTLRRDSSNHKRREPVGQDAVGLK 1740
Cdd:cd21703     1 LPYPLVSVTSEPLKETKFNLLYLLAVAVAIILLILLLGVLVAKRKRKHGPLWFPEGFILNKENSNRKRREPVGQDAVGMK 80


                  ..
gi 134288853 1741 NL 1742
Cdd:cd21703    81 NL 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1820-2042 1.86e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.94  E-value: 1.86e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1820 LDVNVRGPDGCTPLMLAslrggssdlsdededAEDSSANIITDLVYQGASLQAQtDRTGEMALHLAARYSRADAAKRLLD 1899
Cdd:COG0666    78 ADINAKDDGGNTLLHAA---------------ARNGDLEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLE 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1900 AGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVtDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGK 1979
Cdd:COG0666   142 AGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK 220

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 134288853 1980 SALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDH 2042
Cdd:COG0666   221 TALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1859-2063 1.01e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.16  E-value: 1.01e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1859 IITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVtDL 1938
Cdd:COG0666     2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGA-DI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1939 DARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLA 2018
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 134288853 2019 AREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLL 2063
Cdd:COG0666   161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1821-2015 4.84e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.07  E-value: 4.84e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1821 DVNVRGPDGCTPLMLASLRGgssdlsdededaedsSANIITDLVYQGASLQAQtDRTGEMALHLAARYSRADAAKRLLDA 1900
Cdd:COG0666   112 DVNARDKDGETPLHLAAYNG---------------NLEIVKLLLEAGADVNAQ-DNDGNTPLHLAAANGNLEIVKLLLEA 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1901 GADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVtDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKS 1980
Cdd:COG0666   176 GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLT 254

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 134288853 1981 ALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPL 2015
Cdd:COG0666   255 ALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
 1662-1742 1.16e-29

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 114.01  E-value: 1.16e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1662 SYPLVSVFSE-LESPRN---AQLLYLLAVAVVIILFFILLGVIMAKRKRKHGFLWLPEGFTLRRDSSNHKRREPVGQDAV 1737
Cdd:cd21701     1 PYPIYSVRSEpGPATKTtppAQLSPLVVAAVCVLLVLVVLGVLVARKRRRHGTLWFPEGFPRTRASRRSRRRDPVGQDSV 80


                  ....*
gi 134288853 1738 GLKNL 1742
Cdd:cd21701    81 GLKNL 85
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1663-1743 1.88e-26

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 104.83  E-value: 1.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1663 YPLVSVFSEL--ESPRNAQLLYLLAVAVVIILFFILLGVIMAKRKRKHGFLWLPEGFTLRRDSSNHKRREPVGQDAVGLK 1740
Cdd:cd21704     7 YPIKEVRGEKlePPPPPVRLLPLLGVAAVILLVILVLGVLVARRKREHSTLWFPEGFFLKKESSNKNRREPVGQDALGMK 86


                  ...
gi 134288853 1741 NLS 1743
Cdd:cd21704    87 HIA 89
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1539-1594 1.18e-24

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 98.74  E-value: 1.18e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 134288853  1539 PENLAEGTLIIVVLLPPEQLLQDSRSFLRALGTLLHTNLRIKQDSQGALMVYPYFG 1594
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1668-1742 4.44e-19

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 83.69  E-value: 4.44e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 134288853 1668 VFSEL-ESPRNAQLLYLL-AVAVVIILFFILLGVIMA-KRKRKHGFLWLPEGFTLrRDSSNHKRREPVGQDAVGLKNL 1742
Cdd:cd21702     2 VKSETvEPPPPSQLYPMYvVLAALVLLAFVGVGVLVSrKRRREHGQLWFPEGFKV-SEPSKKKRREPVGEDSVGLKPL 78
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1661-1742 3.32e-18

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 81.67  E-value: 3.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1661 LSYPLVSV-FSELESPRNA-------QLLYLLAVAVVIILFFILLGVIMA-KRKRKHGFLWLPEGFTLRRDSSNHKRREP 1731
Cdd:cd21705     1 LPFPLLAVtVEEAEKDPQLvaaqlpwPLVCSSVAGVLALVLGALLGVQLIrRRQREHGALWLPPGFARHRDPNPHRRREP 80

                          90
                  ....*....|.
gi 134288853 1732 VGQDAVGLKNL 1742
Cdd:cd21705    81 VGEDAIGLKPL 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1949-2041 1.34e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 1.34e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853  1949 LILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNgANRDMQDNKeETPLFLAAREGSYEAAK 2028
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 134288853  2029 ILLDHFANRDITD 2041
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1882-1975 4.42e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 4.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853  1882 LHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDarmNDGTTPLILAARLAVEGMV 1961
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 134288853  1962 AELINCQADVNAVD 1975
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1821-2031 1.60e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.91  E-value: 1.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1821 DVNVRGPDGCTPLMlASLRGGSSDlsdededaedssANIITDLVYQGASLQAqTDRTGEMALHLAARYSRADAA--KRLL 1898
Cdd:PHA03095  109 DVNAKDKVGRTPLH-VYLSGFNIN------------PKVIRLLLRKGADVNA-LDLYGMTPLAVLLKSRNANVEllRLLI 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1899 DAGADANAQDNMGRCPLH--AAVAADAQGVFQILIRnRVTDLDARMNDGTTPLILAARLAV--EGMVAELINCQADVNAV 1974
Cdd:PHA03095  175 DAGADVYAVDDRFRSLLHhhLQSFKPRARIVRELIR-AGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINAR 253

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 134288853 1975 DDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILL 2031
Cdd:PHA03095  254 NRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1982-2063 5.82e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 5.82e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853  1982 LHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHfANRDITDHmDRLPRDVARDRMHHDIVR 2061
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVK 78


                   ..
gi 134288853  2062 LL 2063
Cdd:pfam12796   79 LL 80
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1620-1675 1.12e-12

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 64.60  E-value: 1.12e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 134288853  1620 VIGSKIFLEIDNRQCVQDSDQCFKNTDAAAALLASHAIQGTLS--YPLVSVFSELESP 1675
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSSDECFSTAQSAADFLAALAAKGGLDlpYPIKEVRSEPPPP 58
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1878-2038 1.34e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.33  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1878 GEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVA-ADAQGVFQILIRNRVTDlDARMNDGTTPLILAARLA 1956
Cdd:PHA02875   35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEeGDVKAVEELLDLGKFAD-DVFYKDGMTPLHLATILK 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1957 VEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFAN 2036
Cdd:PHA02875  114 KLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193


                  ..
gi 134288853 2037 RD 2038
Cdd:PHA02875  194 ID 195
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1821-2047 1.83e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 72.36  E-value: 1.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1821 DVNVRGPDGCTPLMLAsLRGGSSDLSDededaedssanIITDLVYQGASLQAqTDRTGEMALHLAARYS-RADAAKRLLD 1899
Cdd:PHA03095   39 DVNFRGEYGKTPLHLY-LHYSSEKVKD-----------IVRLLLEAGADVNA-PERCGFTPLHLYLYNAtTLDVIKLLIK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1900 AGADANAQDNMGRCPLHAAVAADA--QGVFQILIRNRVtDLDARMNDGTTPL---ILAARLAVEgMVAELINCQADVNAV 1974
Cdd:PHA03095  106 AGADVNAKDKVGRTPLHVYLSGFNinPKVIRLLLRKGA-DVNALDLYGMTPLavlLKSRNANVE-LLRLLIDAGADVYAV 183

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 134288853 1975 DDHGKSALHWAAAVNNVEATLL--LLKNGANRDMQDNKEETPLFLAAREGSYEAAKI--LLDHFANRDITDHMDRLP 2047
Cdd:PHA03095  184 DDRFRSLLHHHLQSFKPRARIVreLIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTP 260
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1842-2039 3.41e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 71.45  E-value: 3.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1842 SSDLSDEDEDAEDSS--ANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAV 1919
Cdd:PHA02878  130 TIDLVYIDKKSKDDIieAEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAV 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1920 AADAQGVFQILIRNRvTDLDARMNDGTTPL-ILAARLAVEGMVAELINCQADVNAVDD-HGKSALHwaAAVNNVEATLLL 1997
Cdd:PHA02878  210 KHYNKPIVHILLENG-ASTDARDKCGNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLL 286

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 134288853 1998 LKNGANRDMQDNKEETPLFLAAREGS-YEAAKILLDH-----FANRDI 2039
Cdd:PHA02878  287 LEYGADINSLNSYKLTPLSSAVKQYLcINIGRILISNicllkRIKPDI 334
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1890-2036 1.73e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 69.28  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1890 RADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQ---GVFQILIRNRVtDLDARMNDGTTPLILAARLA-VEGMVAELI 1965
Cdd:PHA03095   26 TVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGA-DVNAPERCGFTPLHLYLYNAtTLDVIKLLI 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134288853 1966 NCQADVNAVDDHGKSALHWAAAVNNVEATL--LLLKNGANRDMQDNKEETPL--FLAAREGSYEAAKILLDHFAN 2036
Cdd:PHA03095  105 KAGADVNAKDKVGRTPLHVYLSGFNINPKVirLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGAD 179
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1821-2009 4.24e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 67.77  E-value: 4.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1821 DVNVRGPDGCTPLMLASLRggssdlsdededaEDSSANIITDLVYQGASLQAQTDRtGEMALHLAARYSRADA--AKRLL 1898
Cdd:PHA03100   98 NVNAPDNNGITPLLYAISK-------------KSNSYSIVEYLLDNGANVNIKNSD-GENLLHLYLESNKIDLkiLKLLI 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1899 DAGADANAQDNMgrcplhaavaadaqgvfQILIRNRVtDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHG 1978
Cdd:PHA03100  164 DKGVDINAKNRV-----------------NYLLSYGV-PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG 225

                         170       180       190
                  ....*....|....*....|....*....|.
gi 134288853 1979 KSALHWAAAVNNVEATLLLLKNGANRDMQDN 2009
Cdd:PHA03100  226 DTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1880-2063 4.59e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 67.77  E-value: 4.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1880 MALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLH-----AAVAADAQGVFQILIrNRVTDLDARMNDGTTPLILAAR 1954
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLL-EYGANVNAPDNNGITPLLYAIS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1955 LAVEG--MVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLL------------------LLKNGANRDMQDNKEETP 2014
Cdd:PHA03100  116 KKSNSysIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKILkllidkgvdinaknrvnyLLSYGVPINIKDVYGFTP 195

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 134288853 2015 LFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLL 2063
Cdd:PHA03100  196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
JMTM_dNotch cd21706
juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic ...
 1662-1735 9.97e-11

juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic locus Notch protein (dNotch) and similar proteins; Drosophila melanogaster neurogenic locus Notch protein (dNotch) is an essential signaling protein which has a major role in many developmental processes. It functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. It regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction. It also regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, it is involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt. It might also regulate dpn expression through the activation of the transcriptional regulator Su(H). This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of dNotch, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411989  Cd Length: 90  Bit Score: 60.35  E-value: 9.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1662 SYPLVSVFSELES-----PRNAQLLYLLAVAVVIILFFILLGV-IMAKRKRKHGFLWLPEGFTLRRDSSNH---KRREPV 1732
Cdd:cd21706     1 DFPIYQVRGEDPPdpppePPPSNLTYVVIGVVVVLLIGLLLGVlVTTQRKRARGITWFPEGFFTTSSSQRRrrsRRRGPD 80


                  ...
gi 134288853 1733 GQD 1735
Cdd:cd21706    81 GQE 83
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 182-218 1.99e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 57.65  E-value: 1.99e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  182 DINECDIPGRCQHGGTCLNLPGSYRCQCPQGFTGQHC 218
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1802-2059 3.70e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.47  E-value: 3.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1802 HTPSLA-LTPPQAEQEVDVLDVNVRGPdgcTPLMLASLRGgssdlsdedEDAEDssaniITDLVYQGASLQAqTDRTGEM 1880
Cdd:PHA02876  282 QAPSLSrLVPKLLERGADVNAKNIKGE---TPLYLMAKNG---------YDTEN-----IRTLIMLGADVNA-ADRLYIT 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1881 ALHLAARYSR-ADAAKRLLDAGADANAQDNMGRCPLHAAVAADAqgvfqILIRNRVTDLDARMNDGTTPLILAARLAVEG 1959
Cdd:PHA02876  344 PLHQASTLDRnKDIVITLLELGANVNARDYCDKTPIHYAAVRNN-----VVIINTLLDYGADIEALSQKIGTALHFALCG 418

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1960 M-----VAELINCQADVNAVDDHGKSALHWAAAVN-NVEATLLLLKNGANRDMQDNKEETPLFLAAreGSYEAAKILLDH 2033
Cdd:PHA02876  419 TnpymsVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHY 496

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 134288853 2034 FA--------NRDITDHMDRLPRDVA----RDRMHHDI 2059
Cdd:PHA02876  497 GAelrdsrvlHKSLNDNMFSFRYIIAhiciQDFIRHDI 534
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1875-2047 6.00e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.21  E-value: 6.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1875 DRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNrVTDLDARMNDGTTPL---IL 1951
Cdd:PHA02874  154 DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH-GNHIMNKCKNGFTPLhnaII 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1952 AARLAVEgmvaELINcQADVNAVDDHGKSALHWAAAVN-NVEATLLLLKNGANRDMQDNKEETPLFLAARegSYEAAKIL 2030
Cdd:PHA02874  233 HNRSAIE----LLIN-NASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFK--YINKDPVI 305

                         170
                  ....*....|....*..
gi 134288853 2031 LDHFANRDITDHMDRLP 2047
Cdd:PHA02874  306 KDIIANAVLIKEADKLK 322
EGF_CA smart00179
Calcium-binding EGF-like domain;
182-219 1.35e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 55.33  E-value: 1.35e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    182 DINECDIPGRCQHGGTCLNLPGSYRCQCPQGFT-GQHCD 219
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1423-1456 1.36e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 55.23  E-value: 1.36e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 134288853  1423 ATCQSQYCADKARDGICDEACNSHACQWDGGDCS 1456
Cdd:pfam00066    2 PNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1879-2036 1.42e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.54  E-value: 1.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1879 EMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVE 1958
Cdd:PHA02876  241 DLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYD 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1959 GM-VAELINCQADVNAVDDHGKSALHWAAAVN-NVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFAN 2036
Cdd:PHA02876  321 TEnIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1421-1455 3.80e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 53.87  E-value: 3.80e-09
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 134288853   1421 PPATCQSQYCADKARDGICDEACNSHACQWDGGDC 1455
Cdd:smart00004    4 PWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1821-1999 4.21e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.58  E-value: 4.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1821 DVNVRGPDGCTPLMlASLRggSSDLSDEdedaedssanIITDLVYQGASLQAQTDRtGEMALHLAARYSRADAA--KRLL 1898
Cdd:PHA03095  144 DVNALDLYGMTPLA-VLLK--SRNANVE----------LLRLLIDAGADVYAVDDR-FRSLLHHHLQSFKPRARivRELI 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1899 DAGADANAQDNMGRCPLHAAVAADAQG---VFQILIRNrvTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVD 1975
Cdd:PHA03095  210 RAGCDPAATDMLGNTPLHSMATGSSCKrslVLPLLIAG--ISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287

                         170       180
                  ....*....|....*....|....
gi 134288853 1976 DHGKSALHWAAAVNNVEATLLLLK 1999
Cdd:PHA03095  288 SDGNTPLSLMVRNNNGRAVRAALA 311
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1025-1061 6.93e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.41  E-value: 6.93e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853 1025 DINECSS-NPCLNAGTCVDGLGTYRCICPLGYTGKNCQ 1061
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 873-909 1.69e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 1.69e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  873 DVDECISK-PCMNNGVCHNTQGSYVCECPPGFSGMDCE 909
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1885-2036 1.72e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.59  E-value: 1.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1885 AARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRV----------------------TDLDARM 1942
Cdd:PHA02874   42 AIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVdtsilpipciekdmiktildcgIDVNIKD 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1943 NDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREG 2022
Cdd:PHA02874  122 AELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYG 201

                         170
                  ....*....|....
gi 134288853 2023 SYEAAKILLDHFAN 2036
Cdd:PHA02874  202 DYACIKLLIDHGNH 215
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1501-1534 2.46e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 2.46e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 134288853  1501 KTCKYDkYCADHFKDNHCDQGCNSEECGWDGLDC 1534
Cdd:pfam00066    2 PNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 949-985 3.42e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 3.42e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  949 DMNECLSE-PCKNGGTCSDYVNSYTCTCPAGFHGVHCE 985
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1874-2012 3.50e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 59.11  E-value: 3.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1874 TDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIR-NRVTDLDArmndGTTPLILA 1952
Cdd:PLN03192  554 GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHfASISDPHA----AGDLLCTA 629

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1953 ARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEE 2012
Cdd:PLN03192  630 AKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDD 689
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1225-1262 3.52e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 3.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853 1225 NIDECAGGPHCLNGGQCVDRIGGYTCRCLPGFAGERCE 1262
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_4 pfam13637
Ankyrin repeats (many copies);
1980-2031 3.94e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 3.94e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 134288853  1980 SALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILL 2031
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EGF_CA smart00179
Calcium-binding EGF-like domain;
873-909 4.10e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 51.09  E-value: 4.10e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    873 DVDECISK-PCMNNGVCHNTQGSYVCECPPGFS-GMDCE 909
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1875-2060 7.32e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 57.28  E-value: 7.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1875 DRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTdLDARMNDGTTPLILAAR 1954
Cdd:PHA02874  121 DAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1955 LAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNnvEATLLLLKNGANRDMQDNKEETPLFLAAR-EGSYEAAKILLDH 2033
Cdd:PHA02874  200 YGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN--RSAIELLINNASINDQDIDGSTPLHHAINpPCDIDIIDILLYH 277

                         170       180
                  ....*....|....*....|....*..
gi 134288853 2034 FANRDITDHMDRLPRDVARDRMHHDIV 2060
Cdd:PHA02874  278 KADISIKDNKGENPIDTAFKYINKDPV 304
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 757-793 8.49e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 8.49e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  757 DKNECLS-NPCQNGGTCNNLVNGYRCTCKKGFKGYNCQ 793
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1151-1185 1.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.22e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 134288853 1151 DECAS-NPCQHGATCNDFIGGYRCECVPGYQGVNCE 1185
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 456-492 1.29e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.29e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  456 DINECHS-DPCQNDATCLDKIGGFTCLCMPGFKGVHCE 492
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1025-1061 1.89e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 1.89e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853   1025 DINECSS-NPCLNAGTCVDGLGTYRCICPLGYT-GKNCQ 1061
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1496-1534 2.01e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 49.25  E-value: 2.01e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853   1496 CQRNSKTCKyDKYCADHFKDNHCDQGCNSEECGWDGLDC 1534
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1858-2045 2.13e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.83  E-value: 2.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1858 NIITDLVYQGASLQAQTDRtGEMALHLAARYSRADAA--KRLLDAGADANAQDNMGRCPLHAAVAA--DAQGVFQILIRN 1933
Cdd:PHA03100   87 EIVKLLLEYGANVNAPDNN-GITPLLYAISKKSNSYSivEYLLDNGANVNIKNSDGENLLHLYLESnkIDLKILKLLIDK 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1934 RVtDLDARMNdgttplilaarlavegmVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEET 2013
Cdd:PHA03100  166 GV-DINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227

                         170       180       190
                  ....*....|....*....|....*....|..
gi 134288853 2014 PLFLAAREGSYEAAKILLDHFANrdiTDHMDR 2045
Cdd:PHA03100  228 PLHIAILNNNKEIFKLLLNNGPS---IKTIIE 256
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 495-530 2.17e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 2.17e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  495 VNECQS-NPCVNNGQCVDKVNRFQCLCPPGFTGPVCQ 530
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 911-947 3.66e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.66e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  911 DINDCL-ANPCQNGGSCVDHVNTFSCQCHPGFIGDKCQ 947
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1225-1262 4.38e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 4.38e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853   1225 NIDECAGGPHCLNGGQCVDRIGGYTCRCLPGF-AGERCE 1262
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 415-454 7.40e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 7.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 134288853  415 DVDECAManSNPCEHAGKCVNTDGAFHCECLKGYAGPRCE 454
Cdd:cd00054     1 DIDECAS--GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1151-1185 8.71e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 8.71e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 134288853   1151 DECAS-NPCQHGATCNDFIGGYRCECVPGYQ-GVNCE 1185
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Ank_5 pfam13857
Ankyrin repeats (many copies);
1966-2018 8.92e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 8.92e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 134288853  1966 NCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLA 2018
Cdd:pfam13857    4 HGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1821-1908 9.52e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.96  E-value: 9.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853  1821 DVNVRGPDGCTPLMLASLRGgssdlsdededaedsSANIITDLVYQGASLQAQTDRTgemALHLAARYSRADAAKRLLDA 1900
Cdd:pfam12796   22 DANLQDKNGRTALHLAAKNG---------------HLEIVKLLLEHADVNLKDNGRT---ALHYAARSGHLEIVKLLLEK 83


                   ....*...
gi 134288853  1901 GADANAQD 1908
Cdd:pfam12796   84 GADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1882-2036 9.58e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.30  E-value: 9.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1882 LHLAARY-SRADAAKRLLDAGADANAQDNMGRCPLH--AAVAADAQGVFQILIRNrvTDLDARMNDGTTPLILAARL-AV 1957
Cdd:PHA02876  277 LHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYlmAKNGYDTENIRTLIMLG--ADVNAADRLYITPLHQASTLdRN 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1958 EGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPL-FLAAREGSYEAAKILLDHFAN 2036
Cdd:PHA02876  355 KDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALhFALCGTNPYMSVKTLIDRGAN 434
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 987-1022 1.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 1.03e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  987 NIDECTESS-CFNGGTCVDGINSFSCLCPVGFTGPFC 1022
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 608-643 1.10e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 1.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  608 IDECYS-SPCLNDGRCIDLVNGYQCNCQPGTSGLNCE 643
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1188-1223 1.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853 1188 VDECQ-NQPCQNGGTCIDLVNHFKCSCPPGTRGLLCE 1223
Cdd:cd00054     2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1863-2064 1.17e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.91  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1863 LVYQGASLQAQtDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRvtdldARM 1942
Cdd:PHA02876  164 LLEGGADVNAK-DIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR-----SNI 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1943 NDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATL-LLLKNGANRDMQDNKEETPLFLAARE 2021
Cdd:PHA02876  238 NKNDLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVpKLLERGADVNAKNIKGETPLYLMAKN 317

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 134288853 2022 G-SYEAAKILLDHFANRDITDHMDRLPRDVAR--DRMHHDIVRLLD 2064
Cdd:PHA02876  318 GyDTENIRTLIMLGADVNAADRLYITPLHQAStlDRNKDIVITLLE 363
EGF_CA smart00179
Calcium-binding EGF-like domain;
949-985 1.24e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.24e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    949 DMNECLSE-PCKNGGTCSDYVNSYTCTCPAGFH-GVHCE 985
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 682-717 1.43e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.43e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  682 DIDECAS-NPCRKGATCINDVNGFRCICPEGPHHPSC 717
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
757-793 1.46e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.46e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    757 DKNECLS-NPCQNGGTCNNLVNGYRCTCKKGFK-GYNCQ 793
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1873-2047 2.11e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 53.09  E-value: 2.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1873 QTDRTGEMALHLAARYSRADAAKRLLD-AGADANAQDNMGRCPLHAAVAADAQGVFQILIRNrVTDL-----DARMNDGT 1946
Cdd:cd22192    12 QQKRISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEA-APELvnepmTSDLYQGE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1947 TPLILAARLAVEGMVAELINCQADVN--------------AVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEE 2012
Cdd:cd22192    91 TALHIAVVNQNLNLVRELIARGADVVspratgtffrpgpkNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 134288853 2013 TPLFLAAREGSYEAAKILLDHFANRDITDH---MDRLP 2047
Cdd:cd22192   171 TVLHILVLQPNKTFACQMYDLILSYDKEDDlqpLDLVP 208
EGF_CA smart00179
Calcium-binding EGF-like domain;
456-492 2.15e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 2.15e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    456 DINECHS-DPCQNDATCLDKIGGFTCLCMPGFK-GVHCE 492
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 795-831 2.16e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.16e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  795 NIDECAS-NPCLNQGTCFDDVSGYTCHCMLPYTGKNCQ 831
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1969-2097 3.31e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.19  E-value: 3.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1969 ADVNAVDDH-GKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLP 2047
Cdd:PHA02878  158 ADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTP 237

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 134288853 2048 RDVARDR-MHHDIVRLLDEYNVTPSPPGTVLT-SALSPVLCGPNRSFLSLKH 2097
Cdd:PHA02878  238 LHISVGYcKDYDILKLLLEHGVDVNAKSYILGlTALHSSIKSERKLKLLLEY 289
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1928-2065 3.87e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.89  E-value: 3.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1928 QILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGA----- 2002
Cdd:PHA02874   18 EKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVdtsil 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2003 -----NRDM-------------QDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLD 2064
Cdd:PHA02874   98 pipciEKDMiktildcgidvniKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLL 177


                  .
gi 134288853 2065 E 2065
Cdd:PHA02874  178 E 178
EGF_CA smart00179
Calcium-binding EGF-like domain;
682-711 4.26e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.26e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 134288853    682 DIDECAS-NPCRKGATCINDVNGFRCICPEG 711
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 532-567 4.41e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 4.41e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  532 DIDDCSST-PCLNGAKCIDHPNGYECQCATGFTGILC 567
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Ank_5 pfam13857
Ankyrin repeats (many copies);
1874-1918 4.46e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.80  E-value: 4.46e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 134288853  1874 TDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAA 1918
Cdd:pfam13857   12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1463-1497 5.60e-06

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 44.83  E-value: 5.60e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 134288853  1463 WANCTSTlRCWEYINN-QCDEQCNTAECLFDNFECQ 1497
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNgVCDEECNNAECLWDGGDCS 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
415-454 6.25e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 6.25e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 134288853    415 DVDECAManSNPCEHAGKCVNTDGAFHCECLKGY-AGPRCE 454
Cdd:smart00179    1 DIDECAS--GNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 298-335 6.46e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 6.46e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  298 DVDECLlQPNACQNGGTCTNRNGGYGCVCVNGWSGDDC 335
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 185-217 7.85e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 44.77  E-value: 7.85e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 134288853  185 ECDIPGRCQHGGTCLNLPGSYRCQCPQGFTGQH 217
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
494-530 8.56e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 8.56e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    494 EVNECQS-NPCVNNGQCVDKVNRFQCLCPPGFT-GPVCQ 530
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1187-1223 1.06e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.06e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853   1187 EVDECQ-NQPCQNGGTCIDLVNHFKCSCPPG-TRGLLCE 1223
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1029-1059 1.19e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.91  E-value: 1.19e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853  1029 CSSNPCLNAGTCVDGLGTYRCICPLGYTGKN 1059
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
608-643 1.33e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.33e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134288853    608 IDECYS-SPCLNDGRCIDLVNGYQCNCQPG-TSGLNCE 643
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1823-2015 1.44e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.99  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1823 NVRGPDGCTPLMLASLRGGSSDLsdedEDAEDSSaNIITDLVYqgaslqaqtdRTGEMALHLAARYSRADAAKRLLDAGA 1902
Cdd:PHA02875   62 DVKYPDIESELHDAVEEGDVKAV----EELLDLG-KFADDVFY----------KDGMTPLHLATILKKLDIMKLLIARGA 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1903 DANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTdLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSAL 1982
Cdd:PHA02875  127 DPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKAC-LDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 134288853 1983 HWAAAVNN-VEATLLLLKNGANRD---MQDNKEETPL 2015
Cdd:PHA02875  206 LCYAIENNkIDIVRLFIKRGADCNimfMIEGEECTIL 242
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1459-1496 1.50e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 43.85  E-value: 1.50e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853   1459 MEDPWANCTStLRCWEYINN-QCDEQCNTAECLFDNFEC 1496
Cdd:smart00004    1 PQDPWSRCED-AQCWDKFGDgVCDEECNNAECLWDGGDC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
911-947 1.59e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.59e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    911 DINDCL-ANPCQNGGSCVDHVNTFSCQCHPGFI-GDKCQ 947
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1878-2026 2.05e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1878 GEMALHLAARYSRADAAKRLLDAGAD-----ANAQDNMGRCPLHAAVAADAQGVFQILIRN-------RVTDLDARMND- 1944
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLMEAAPElvnepMTSDLYQGETALHIAVVNQNLNLVRELIARgadvvspRATGTFFRPGPk 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1945 -----GTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEAT-----LLL----LKNGANRDMQDNK 2010
Cdd:cd22192   131 nliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFAcqmydLILsydkEDDLQPLDLVPNN 210

                         170
                  ....*....|....*..
gi 134288853 2011 EE-TPLFLAAREGSYEA 2026
Cdd:cd22192   211 QGlTPFKLAAKEGNIVM 227
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2069-2424 2.24e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2069 TPSPPGTvltSALSPVLCGPnrsflslkhTPMGKKARRPNTKSTMPTSLPNLAKEAKDAKGSRRKKCLNEKVQLSESS-- 2146
Cdd:PHA03247 2615 SPLPPDT---HAPDPPPPSP---------SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPqr 2682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2147 -------VTLSPVDSLESPHTYVSDATSSPMITSPGiLQASPTPLLAAAAPAAPVHTQHALSFSNlhdmQPLAPGASTVL 2219
Cdd:PHA03247 2683 prrraarPTVGSLTSLADPPPPPPTPEPAPHALVSA-TPLPPGPAAARQASPALPAAPAPPAVPA----GPATPGGPARP 2757

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2220 PSVSQLLSHHHIAPPGSSSAGSLGRLHPVPVPADWMNRVEMNETQYSEMFGMVLAPAEGAHPGIAAPQS-RPPEGKHMST 2298
Cdd:PHA03247 2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGpLPPPTSAQPT 2837

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2299 QREPLPPIVTFQLIPKGSIA------------QAAGAPQTQSSCP------PAVAGPLPSMYQIP---EMPRLPSVAFPP 2357
Cdd:PHA03247 2838 APPPPPGPPPPSLPLGGSVApggdvrrrppsrSPAAKPAAPARPPvrrlarPAVSRSTESFALPPdqpERPPQPQAPPPP 2917

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134288853 2358 TMMPQQEGQVAQTIVPTYHPFPASvgkyPTPPSQHSYASSNA--AERTPSHGGHLQGEHP---YLTPSPESP 2424
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQP----PLAPTTDPAGAGEPsgAVPQPWLGALVPGRVAvprFRVPQPAPS 2985
EGF_CA smart00179
Calcium-binding EGF-like domain;
987-1022 2.86e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.86e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134288853    987 NIDECTESS-CFNGGTCVDGINSFSCLCPVGFT-GPFC 1022
Cdd:smart00179    1 DIDECASGNpCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
Ank_4 pfam13637
Ankyrin repeats (many copies);
1881-1931 3.67e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 3.67e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 134288853  1881 ALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILI 1931
Cdd:pfam13637    4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1964-2033 3.80e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.13  E-value: 3.80e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1964 LINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDH 2033
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 260-296 4.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 4.05e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134288853  260 NIDDC-PNHKCQNGGVCVDGVNTYNCRCPPQWTGQFCT 296
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2108-2424 4.24e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.00  E-value: 4.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853  2108 NTKSTMPtSLPNLAKEAKDAKGSRRKKCLN-EKVQLSESSVTLSPVDSLESPHTYVSDAT-----------SSPMITSPG 2175
Cdd:pfam03154  140 DNRSTSP-SIPSPQDNESDSDSSAQQQILQtQPPVLQAQSGAASPPSPPPPGTTQAATAGptpsapsvppqGSPATSQPP 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853  2176 ILQASPTPLLAAAAPAAPVHTQHALS-FSNLHDMQPLAPgASTVLPSVSQLLSHHHIAPPGSSS--AGSLGRLHPVPvpa 2252
Cdd:pfam03154  219 NQTQSTAAPHTLIQQTPTLHPQRLPSpHPPLQPMTQPPP-PSQVSPQPLPQPSLHGQMPPMPHSlqTGPSHMQHPVP--- 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853  2253 dwmnrvemnetqySEMFGMVLAPAEGAHPgiAAPQSRPPegkHMSTQREPLPPivtfqlipkgsiaqaaGAPQTQSSCPP 2332
Cdd:pfam03154  295 -------------PQPFPLTPQSSQSQVP--PGPSPAAP---GQSQQRIHTPP----------------SQSQLQSQQPP 340

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853  2333 AvAGPL-PSMYQIPEMPRLPSVAFPPTMMPQQEGQVAQTIVPTYHPFPASVgkyPTPPSQHSYASSNAAERTPSHGGHLQ 2411
Cdd:pfam03154  341 R-EQPLpPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNL---PPPPALKPLSSLSTHHPPSAHPPPLQ 416

                          330
                   ....*....|....*
gi 134288853  2412 --GEHPYLTPSPESP 2424
Cdd:pfam03154  417 lmPQSQQLPPPPAQP 431
PHA02946 PHA02946
ankyin-like protein; Provisional
 1860-2017 4.80e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.51  E-value: 4.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1860 ITDLVYQGASlQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQIlirNRVTDLD 1939
Cdd:PHA02946   55 VEELLHRGYS-PNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERI---NLLVQYG 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1940 ARMN-----DGTTPLiLAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLL--LLKNGANRDMQDNKEE 2012
Cdd:PHA02946  131 AKINnsvdeEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDNPKASTIswMMKLGISPSKPDHDGN 209


                  ....*
gi 134288853 2013 TPLFL 2017
Cdd:PHA02946  210 TPLHI 214
EGF_CA smart00179
Calcium-binding EGF-like domain;
532-563 5.36e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 5.36e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 134288853    532 DIDDCSST-PCLNGAKCIDHPNGYECQCATGFT 563
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
795-831 6.79e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 6.79e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    795 NIDECAS-NPCLNQGTCFDDVSGYTCHCMLPYT-GKNCQ 831
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1949-2063 9.51e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.94  E-value: 9.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1949 LILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLF------------ 2016
Cdd:PLN03192  529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWnaisakhhkifr 608

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 134288853 2017 -------------------LAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLL 2063
Cdd:PLN03192  609 ilyhfasisdphaagdllcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLL 674
EGF_CA pfam07645
Calcium-binding EGF domain;
873-902 9.76e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 9.76e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134288853   873 DVDECIS--KPCMNNGVCHNTQGSYVCECPPG 902
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1878-2045 1.05e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 47.83  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1878 GEMALHLAARYSRADAAKRLLDAGADANAQdnmgrcplhaavaadAQGVFqilirnrvtdLDARMND-----GTTPLILA 1952
Cdd:cd22194   141 GQTALNIAIERRQGDIVKLLIAKGADVNAH---------------AKGVF----------FNPKYKHegfyfGETPLALA 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1953 ARLAVEGMVAELI-NCQADVNAVDDHGKSALH-----------WAAAVNNVEATLLLLKNGANRDMQDNKEE-TPLFLAA 2019
Cdd:cd22194   196 ACTNQPEIVQLLMeKESTDITSQDSRGNTVLHalvtvaedsktQNDFVKRMYDMILLKSENKNLETIRNNEGlTPLQLAA 275

                         170       180
                  ....*....|....*....|....*.
gi 134288853 2020 REGSYEaakiLLDHFANRDITDHMDR 2045
Cdd:cd22194   276 KMGKAE----ILKYILSREIKEKPNR 297
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 536-564 1.10e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 1.10e-04
                           10        20
                   ....*....|....*....|....*....
gi 134288853   536 CSSTPCLNGAKCIDHPNGYECQCATGFTG 564
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
298-335 1.34e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.34e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    298 DVDECLlQPNACQNGGTCTNRNGGYGCVCVNGWS-GDDC 335
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
Ank_4 pfam13637
Ankyrin repeats (many copies);
1945-1998 1.50e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 1.50e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 134288853  1945 GTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLL 1998
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 645-679 1.72e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.72e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  645 NFDDCAS-NPCM-HGVCVDGINRYSCVCSPGFTGQRC 679
Cdd:cd00054     1 DIDECASgNPCQnGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1153-1183 3.78e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 3.78e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853  1153 CASNPCQHGATCNDFIGGYRCECVPGYQGVN 1183
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 189-217 4.17e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 4.17e-04
                           10        20
                   ....*....|....*....|....*....
gi 134288853   189 PGRCQHGGTCLNLPGSYRCQCPQGFTGQH 217
Cdd:pfam00008    3 PNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 761-789 5.12e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 5.12e-04
                           10        20
                   ....*....|....*....|....*....
gi 134288853   761 CLSNPCQNGGTCNNLVNGYRCTCKKGFKG 789
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 498-527 5.12e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 5.12e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 134288853   498 CQSNPCVNNGQCVDKVNRFQCLCPPGFTGP 527
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1228-1260 5.25e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.38  E-value: 5.25e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 134288853 1228 ECAGGPHCLNGGQCVDRIGGYTCRCLPGFAGER 1260
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 1815-2051 6.39e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 45.17  E-value: 6.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1815 QEVDVLDVNVRGPD-GCTPLMLA--SLRGGSSDLS------DEDEDAEDSSANI-ITDLVYQGASlqaqtdrtgemALHL 1884
Cdd:cd22193    14 RRKDLTDSEFTESStGKTCLMKAllNLNPGTNDTIrilldiAEKTDNLKRFINAeYTDEYYEGQT-----------ALHI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1885 AARYSRADAAKRLLDAGADANAQdnmgrcplhaavaadAQGVFqilirNRVTDLDARMNDGTTPLILAA---RLAVEGMV 1961
Cdd:cd22193    83 AIERRQGDIVALLVENGADVHAH---------------AKGRF-----FQPKYQGEGFYFGELPLSLAActnQPDIVQYL 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1962 AELINCQADVNAVDDHGKSALHWAAAV--NNVEATLL-------LLKNGAN-------RDMQDNKEETPLFLAAREGSYE 2025
Cdd:cd22193   143 LENEHQPADIEAQDSRGNTVLHALVTVadNTKENTKFvtrmydmILIRGAKlcptvelEEIRNNDGLTPLQLAAKMGKIE 222

                         250       260       270
                  ....*....|....*....|....*....|
gi 134288853 2026 aakiLLDHFANRDITD----HMDRLPRDVA 2051
Cdd:cd22193   223 ----ILKYILQREIKEpelrHLSRKFTDWA 248
EGF_CA pfam07645
Calcium-binding EGF domain;
682-711 6.62e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 6.62e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134288853   682 DIDECAS--NPCRKGATCINDVNGFRCICPEG 711
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1983-2071 6.75e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 6.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1983 HWAAAVNNVEATLLLlKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRL 2062
Cdd:PTZ00322   88 QLAASGDAVGARILL-TGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                  ....*....
gi 134288853 2063 LDEYNVTPS 2071
Cdd:PTZ00322  167 LSRHSQCHF 175
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 953-983 7.02e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.02e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853   953 CLSEPCKNGGTCSDYVNSYTCTCPAGFHGVH 983
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 799-829 7.67e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.67e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853   799 CASNPCLNQGTCFDDVSGYTCHCMLPYTGKN 829
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 915-944 7.89e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.89e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 134288853   915 CLANPCQNGGSCVDHVNTFSCQCHPGFIGD 944
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA pfam07645
Calcium-binding EGF domain;
182-212 7.98e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 7.98e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134288853   182 DINECDIPGR-CQHGGTCLNLPGSYRCQCPQG 212
Cdd:pfam07645    1 DVDECATGTHnCPANTVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1152-1185 1.21e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 134288853 1152 ECA-SNPCQHGATCNDFIGGYRCECVPGYQGV-NCE 1185
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1028-1061 1.31e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 1.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 134288853 1028 ECS-SNPCLNAGTCVDGLGTYRCICPLGYTG-KNCQ 1061
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1875-2038 1.33e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.09  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1875 DRTGE-----MALHLAARYSRADAA--KRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNrVTDLDARMNDGTT 1947
Cdd:PLN03192  515 DNGGEhddpnMASNLLTVASTGNAAllEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKH-ACNVHIRDANGNT 593

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1948 PLILAARLAVEGMVAELINCQAdvnAVDDH-GKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEA 2026
Cdd:PLN03192  594 ALWNAISAKHHKIFRILYHFAS---ISDPHaAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDM 670

                         170
                  ....*....|..
gi 134288853 2027 AKILLDHFANRD 2038
Cdd:PLN03192  671 VRLLIMNGADVD 682
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 570-604 1.48e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134288853  570 NIDNCD-PDPC-HHGQCQDGIDSYTCICNPGYMGAIC 604
Cdd:cd00054     1 DIDECAsGNPCqNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1264-1302 1.66e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 134288853 1264 DINECLS-NPCSSEGSldCVQLKNNYNCICRSAFTGRHCE 1302
Cdd:cd00054     1 DIDECASgNPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
PHA03378 PHA03378
EBNA-3B; Provisional
 2273-2426 1.73e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.90  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2273 LAPAEGAHPGIAAPQSRPPEGKHMSTQREPLPPIVTFQLIPKGSIAQAAGAPQTQSscPPAVAGPL--PSMYQIPEMPRL 2350
Cdd:PHA03378  598 PVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQ--PPQVEITPykPTWTQIGHIPYQ 675

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 134288853 2351 PSVAFPPTMMPQQEG-QVAQTivPTYHPFPASVGKYPTPPSQHSYASSNAAErtPSHGGHLQGEHPYLTPSPESPDQ 2426
Cdd:PHA03378  676 PSPTGANTMLPIQWApGTMQP--PPRAPTPMRPPAAPPGRAQRPAAATGRAR--PPAAAPGRARPPAAAPGRARPPA 748
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1117-1147 1.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.75e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 134288853 1117 EHLCQHSGICINAGNTHHCQCPLGYTGSYCE 1147
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1312-1343 1.87e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.87e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 134288853 1312 PCLNGGTCavaSNMPDGFICRCPPGFSGARCQ 1343
Cdd:cd00054    10 PCQNGGTC---VNTVGSYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 879-905 1.92e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.84  E-value: 1.92e-03
                          10        20
                  ....*....|....*....|....*..
gi 134288853  879 SKPCMNNGVCHNTQGSYVCECPPGFSG 905
Cdd:cd00053     5 SNPCSNGGTCVNTPGSYRCVCPPGYTG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1191-1219 2.33e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.33e-03
                           10        20
                   ....*....|....*....|....*....
gi 134288853  1191 CQNQPCQNGGTCIDLVNHFKCSCPPGTRG 1219
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA pfam07645
Calcium-binding EGF domain;
298-329 2.38e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 2.38e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134288853   298 DVDECLLQPNACQNGGTCTNRNGGYGCVCVNG 329
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 918-945 2.66e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 2.66e-03
                          10        20
                  ....*....|....*....|....*...
gi 134288853  918 NPCQNGGSCVDHVNTFSCQCHPGFIGDK 945
Cdd:cd00053     6 NPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 460-490 2.67e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.67e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853   460 CHSDPCQNDATCLDKIGGFTCLCMPGFKGVH 490
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
260-296 2.74e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.74e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134288853    260 NIDDC-PNHKCQNGGVCVDGVNTYNCRCPPQWT-GQFCT 296
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
456-485 3.04e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 3.04e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134288853   456 DINECHS--DPCQNDATCLDKIGGFTCLCMPG 485
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
PHA03378 PHA03378
EBNA-3B; Provisional
 2233-2405 3.14e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2233 PPGSSSAGSLGRLHPVPVPADWMNRVEMN----ETQYSEMFGMVLAPAEGAHPGIAAPQSRPPEGKHMSTQReplPPIVT 2308
Cdd:PHA03378  645 VLVFPTPHQPPQVEITPYKPTWTQIGHIPyqpsPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQR---PAAAT 721

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2309 FQLIPKGSIAQAAGAPQTQSS--CPPAVAGPLPSMYQIPEMPRLPSVAFPPTMMPQQEGQVAQTivPTYHPfpaSVGKYP 2386
Cdd:PHA03378  722 GRARPPAAAPGRARPPAAAPGraRPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPA--PQQRP---RGAPTP 796

                         170
                  ....*....|....*....
gi 134288853 2387 TPPSQHSYASSNAAERTPS 2405
Cdd:PHA03378  797 QPPPQAGPTSMQLMPRAAP 815
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1878-1909 3.33e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 3.33e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 134288853  1878 GEMALHLAA-RYSRADAAKRLLDAGADANAQDN 1909
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1977-2009 3.33e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 3.33e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 134288853  1977 HGKSALHWAAA-VNNVEATLLLLKNGANRDMQDN 2009
Cdd:pfam00023    1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1196-1216 3.43e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.93  E-value: 3.43e-03
                           10        20
                   ....*....|....*....|.
gi 134288853  1196 CQNGGTCIDLVNHFKCSCPPG 1216
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPG 21
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 760-789 3.54e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 3.54e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 134288853  760 EC-LSNPCQNGGTCNNLVNGYRCTCKKGFKG 789
Cdd:cd00053     1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTG 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 497-527 3.87e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 3.87e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 134288853  497 ECQ-SNPCVNNGQCVDKVNRFQCLCPPGFTGP 527
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1226-1255 4.04e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 4.04e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853  1226 IDECAGGPH-CLNGGQCVDRIGGYTCRCLPG 1255
Cdd:pfam07645    2 VDECATGTHnCPANTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
185-216 4.35e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.73  E-value: 4.35e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 134288853    185 ECDIPGRCQHGgTCLNLPGSYRCQCPQGFTGQ 216
Cdd:smart00181    1 ECASGGPCSNG-TCINTPGSYTCSCPPGYTGD 31
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2069-2415 4.43e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2069 TPSPPGTVLTSALSPVLCGPN--RSFLSLKHTPMGKKAR-RPNTKSTMPTSLPnlakEAKDAKGSRRKKCLNEKVQLSES 2145
Cdd:PHA03247 2719 TPLPPGPAAARQASPALPAAPapPAVPAGPATPGGPARPaRPPTTAGPPAPAP----PAAPAAGPPRRLTRPAVASLSES 2794

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2146 SVTL-SPVDSLESPHTYVSDATSSPMITSPGILQASPTPLLAAAAPAAPVHTQHALSFSNlhdmqPLAPGASTvlpsvsq 2224
Cdd:PHA03247 2795 RESLpSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG-----SVAPGGDV------- 2862

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2225 llshHHIAPPGSSSAGSLGRLHPvpvPADWMNRVEMNETQYSemfgMVLAPAEGAHPGIAAPQSRPPEGKHMSTQREPLP 2304
Cdd:PHA03247 2863 ----RRRPPSRSPAAKPAAPARP---PVRRLARPAVSRSTES----FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2305 PIvtfqliPKGSIAQAAGAPQTQSSCPPAVAGPLPSMYQIPEMPrlPSVAFPPTMMPQQEGQVaqtivptyhPFPAsvgk 2384
Cdd:PHA03247 2932 PP------PPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP--GRVAVPRFRVPQPAPSR---------EAPA---- 2990

                         330       340       350
                  ....*....|....*....|....*....|.
gi 134288853 2385 yPTPPSQHSYASSNAAERTPSHGGHLQGEHP 2415
Cdd:PHA03247 2991 -SSTPPLTGHSLSRVSSWASSLALHEETDPP 3020
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 611-641 4.54e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.54e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853   611 CYSSPCLNDGRCIDLVNGYQCNCQPGTSGLN 641
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2267-2425 4.98e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 4.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2267 EMFGMVLAP--AEGAHPGIAAPQSRPPEGKHMSTQREPLPPIVTfqlIPKGSIAQAAGAPQTQSSCPPAVAGPLP----- 2339
Cdd:PRK07764  576 EELGGDWQVeaVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPA---APAAPAAPAPAGAAAAPAEASAAPAPGVaapeh 652

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2340 ---------SMYQIPEMPRLPSVAFP--PTMMPQQEGQVAQTIVPTYHPFPASVgkyPTPPSQHSYASSNAAERTPSHGG 2408
Cdd:PRK07764  653 hpkhvavpdASDGGDGWPAKAGGAAPaaPPPAPAPAAPAAPAGAAPAQPAPAPA---ATPPAGQADDPAAQPPQAAQGAS 729

                         170
                  ....*....|....*..
gi 134288853 2409 HLQGEHPYLTPSPESPD 2425
Cdd:PRK07764  730 APSPAADDPVPLPPEPD 746
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1235-1256 5.08e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.54  E-value: 5.08e-03
                           10        20
                   ....*....|....*....|..
gi 134288853  1235 CLNGGQCVDRIGGYTCRCLPGF 1256
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 952-985 5.25e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 5.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 134288853  952 EC-LSEPCKNGGTCSDYVNSYTCTCPAGFHGV-HCE 985
Cdd:cd00053     1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
Ank_5 pfam13857
Ankyrin repeats (many copies);
1930-1985 5.29e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 5.29e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 134288853  1930 LIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWA 1985
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 877-905 5.48e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 5.48e-03
                           10        20
                   ....*....|....*....|....*....
gi 134288853   877 CISKPCMNNGVCHNTQGSYVCECPPGFSG 905
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 423-452 5.98e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 5.98e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 134288853   423 NSNPCEHAGKCVNTDGAFHCECLKGYAGPR 452
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 991-1021 6.16e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 6.16e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134288853   991 CTESSCFNGGTCVDGINSFSCLCPVGFTGPF 1021
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2274-2426 6.17e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 6.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2274 APAEGAHPGIAAPQSRPPEGKHMSTQREPLPPIVTFQLIPKGSIAQAAGAPQTQSS--------CPPAVAGPLPSMYQIP 2345
Cdd:PRK12323  398 APAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPApaaapaaaARPAAAGPRPVAAAAA 477

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 2346 EMPRLPSVAFPPTmmPQQEGQVAQTIVPTYHPFPASVGKYPTPPSQHSYASSNAAERTPSHGGHLQGEHPYLTPSPESPD 2425
Cdd:PRK12323  478 AAPARAAPAAAPA--PADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAA 555


                  .
gi 134288853 2426 Q 2426
Cdd:PRK12323  556 A 556
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 192-213 6.76e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.16  E-value: 6.76e-03
                           10        20
                   ....*....|....*....|..
gi 134288853   192 CQHGGTCLNLPGSYRCQCPQGF 213
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1875-1943 6.91e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 6.91e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 134288853 1875 DRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMN 1943
Cdd:PTZ00322  112 DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGAN 180
EGF_CA smart00179
Calcium-binding EGF-like domain;
645-679 7.12e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.12e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134288853    645 NFDDCAS-NPCMHG-VCVDGINRYSCVCSPGFT-GQRC 679
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNC 38
PHA02946 PHA02946
ankyin-like protein; Provisional
 1943-2073 7.16e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.58  E-value: 7.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1943 NDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNN--VEATLLLLKNGANRDMQDNKEETPLFLAAR 2020
Cdd:PHA02946   70 DDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKINNSVDEEGCGPLLACT 149

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 134288853 2021 EGSYEAAKILLDHFANRDITDHM--DRLPRDVARDRMHHDIVRLLDEYNVTPSPP 2073
Cdd:PHA02946  150 DPSERVFKKIMSIGFEARIVDKFgkNHIHRHLMSDNPKASTISWMMKLGISPSKP 204
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 958-979 7.75e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.77  E-value: 7.75e-03
                           10        20
                   ....*....|....*....|..
gi 134288853   958 CKNGGTCSDYVNSYTCTCPAGF 979
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 109-143 8.29e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 8.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 134288853  109 CFVSRPCQNGGTCHMLsRDTYECTCQVGFTGKQCQ 143
Cdd:cd00054     5 CASGNPCQNGGTCVNT-VGSYRCSCPPGYTGRNCE 38
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 1878-2045 8.97e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 41.33  E-value: 8.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1878 GEMALHLAARYSRADAAKRLLDAGADANAQdnmgrcplhaavaadAQGVFQILIRNRvtdldARMNDGTTPLILAA---R 1954
Cdd:cd22196    94 GQTALHIAIERRNMHLVELLVQNGADVHAR---------------ASGEFFKKKKGG-----PGFYFGELPLSLAActnQ 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134288853 1955 LAVEGMVAELINCQADVNAVDDHGKSALHWAAAV--NNVEAT---------LLLLKNGAN-----RDMQDNKEETPLFLA 2018
Cdd:cd22196   154 LDIVKFLLENPHSPADISARDSMGNTVLHALVEVadNTPENTkfvtkmyneILILGAKIRpllklEEITNKKGLTPLKLA 233

                         170       180       190
                  ....*....|....*....|....*....|.
gi 134288853 2019 AREGSYEaakiLLDHFANRDITD----HMDR 2045
Cdd:cd22196   234 AKTGKIG----IFAYILGREIKEpecrHLSR 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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