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Conserved domains on  [gi|8567370|ref|NP_034834|]
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leptin receptor isoform 2 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 429-531 3.52e-42

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


:

Pssm-ID: 465812  Cd Length: 105  Bit Score: 149.03  E-value: 3.52e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370    429 NINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHP--TSEPKNCVLQRDGFYECVFQPIFLLSG 506
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLADSKVNLRYRRSELSCEDRSTSSLkgGSMVKECDCQGPGFYECTIQPLYLNST 80

                          90       100
                  ....*....|....*....|....*
gi 8567370    507 YTMWIRINHSLGSLDSPPTCVLPDS 531
Cdd:pfam18589  81 YIMWLEISHGLGPLQSPPMSVKPID 105
ObR_Ig super family cl39908
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 126-231 1.36e-21

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


The actual alignment was detected with superfamily member pfam18589:

Pssm-ID: 465812  Cd Length: 105  Bit Score: 90.48  E-value: 1.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370    126 NWDIECWMKGDLTLFICHMEPLPKNPFKnyDSKVHLLYDLPEV-IDDSPLPPLKDSFQTVQCNCSL-RGCECHVPVPRak 203
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLA--DSKVNLRYRRSELsCEDRSTSSLKGGSMVKECDCQGpGFYECTIQPLY-- 76

                          90       100
                  ....*....|....*....|....*...
gi 8567370    204 LNYALLMYLEITSAGVSFQSPLMSLQPM 231
Cdd:pfam18589  77 LNSTYIMWLEISHGLGPLQSPPMSVKPI 104
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 327-418 1.59e-18

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 81.13  E-value: 1.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370    327 TTQDVVYFPPKIlTSVGSNASFHCIYKN---ENQIISSKQIVWWRNLaEKIPEIQYSIVSDRVSKVTFSNLKATRPrgkf 403
Cdd:pfam06328   1 EPCGHISPSPPV-VRLGSNVTASCILKEnccSHLGVEAQIIVWKLGL-ELIPGSQYTVLNDTVSSVTLPNLNSTRA---- 74

                          90
                  ....*....|....*.
gi 8567370    404 tydAVYCCNE-QACHH 418
Cdd:pfam06328  75 ---LLTCCLLwGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 236-328 2.54e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 2.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370  236 PDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQ-YQVKYLE--NSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 312
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgYVVEYREkgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                        90
                ....*....|....*.
gi 8567370  313 GsgvWSDWSSPQVFTT 328
Cdd:cd00063  81 G---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 737-818 1.62e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 1.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370     737 SAVESLSAYPLSSSCVILSWTLSPDDYSLLYlVIEWKILNEDDGMKWLRIPSNVKK-FYIHDNFIPIEKYQFSLYPVFME 815
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGY-IVGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 8567370     816 GVG 818
Cdd:smart00060  81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 535-625 7.81e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 7.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370  535 PLPPSNVKAEITVNTGLLkVSWEKPVFPENNLQ-FQIRYGLSGKEiQWKTHEVFDAKSKSASL--LVSDlcAVYVVQVRC 611
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVT-LSWTPPEDDGGPITgYVVEYREKGSG-DWKEVEVTPGSETSYTLtgLKPG--TEYEFRVRA 76

                        90
                ....*....|....
gi 8567370  612 RRLDGLGYWSNWSS 625
Cdd:cd00063  77 VNGGGESPPSESVT 90
 
Name Accession Description Interval E-value
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 429-531 3.52e-42

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 149.03  E-value: 3.52e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370    429 NINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHP--TSEPKNCVLQRDGFYECVFQPIFLLSG 506
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLADSKVNLRYRRSELSCEDRSTSSLkgGSMVKECDCQGPGFYECTIQPLYLNST 80

                          90       100
                  ....*....|....*....|....*
gi 8567370    507 YTMWIRINHSLGSLDSPPTCVLPDS 531
Cdd:pfam18589  81 YIMWLEISHGLGPLQSPPMSVKPID 105
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 126-231 1.36e-21

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 90.48  E-value: 1.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370    126 NWDIECWMKGDLTLFICHMEPLPKNPFKnyDSKVHLLYDLPEV-IDDSPLPPLKDSFQTVQCNCSL-RGCECHVPVPRak 203
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLA--DSKVNLRYRRSELsCEDRSTSSLKGGSMVKECDCQGpGFYECTIQPLY-- 76

                          90       100
                  ....*....|....*....|....*...
gi 8567370    204 LNYALLMYLEITSAGVSFQSPLMSLQPM 231
Cdd:pfam18589  77 LNSTYIMWLEISHGLGPLQSPPMSVKPI 104
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 327-418 1.59e-18

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 81.13  E-value: 1.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370    327 TTQDVVYFPPKIlTSVGSNASFHCIYKN---ENQIISSKQIVWWRNLaEKIPEIQYSIVSDRVSKVTFSNLKATRPrgkf 403
Cdd:pfam06328   1 EPCGHISPSPPV-VRLGSNVTASCILKEnccSHLGVEAQIIVWKLGL-ELIPGSQYTVLNDTVSSVTLPNLNSTRA---- 74

                          90
                  ....*....|....*.
gi 8567370    404 tydAVYCCNE-QACHH 418
Cdd:pfam06328  75 ---LLTCCLLwGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 236-328 2.54e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 2.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370  236 PDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQ-YQVKYLE--NSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 312
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgYVVEYREkgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                        90
                ....*....|....*.
gi 8567370  313 GsgvWSDWSSPQVFTT 328
Cdd:cd00063  81 G---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 236-315 3.78e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 3.78e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370     236 PDPPLGLHMEVTDDGNLKISWDSQTMAP---FPLQYQVKYLENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 312
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 8567370     313 GSG 315
Cdd:smart00060  81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 737-818 1.62e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 1.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370     737 SAVESLSAYPLSSSCVILSWTLSPDDYSLLYlVIEWKILNEDDGMKWLRIPSNVKK-FYIHDNFIPIEKYQFSLYPVFME 815
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGY-IVGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 8567370     816 GVG 818
Cdd:smart00060  81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
233-409 2.16e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 2.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370  233 VVKPDPPLGLHMEVTDDGNLKISWDSQTmAPFPLQYQVKY-LENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKrl 311
Cdd:COG3401 324 LTPPAAPSGLTATAVGSSSITLSWTASS-DADVTGYNVYRsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV-- 400

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370  312 DGSGVWSDWSSPqVFTTQDVVYFPPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVS-DRVSKVT 390
Cdd:COG3401 401 DAAGNESAPSEE-VSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTtTSSTVTA 479

                       170
                ....*....|....*....
gi 8567370  391 FSNLKATRPRGKFTYDAVY 409
Cdd:COG3401 480 TTTDTTTANLSVTTGSLVG 498
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 737-820 6.06e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.48  E-value: 6.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370  737 SAVESLSAYPLSSSCVILSWTLSPDDYSLL--YlVIEWKILNEDDGMKWLRIPSNVKKFYIhDNFIPIEKYQFSLYPVFM 814
Cdd:cd00063   2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPItgY-VVEYREKGSGDWKEVEVTPGSETSYTL-TGLKPGTEYEFRVRAVNG 79


                ....*.
gi 8567370  815 EGVGKP 820
Cdd:cd00063  80 GGESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 535-625 7.81e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 7.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370  535 PLPPSNVKAEITVNTGLLkVSWEKPVFPENNLQ-FQIRYGLSGKEiQWKTHEVFDAKSKSASL--LVSDlcAVYVVQVRC 611
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVT-LSWTPPEDDGGPITgYVVEYREKGSG-DWKEVEVTPGSETSYTLtgLKPG--TEYEFRVRA 76

                        90
                ....*....|....
gi 8567370  612 RRLDGLGYWSNWSS 625
Cdd:cd00063  77 VNGGGESPPSESVT 90
fn3 pfam00041
Fibronectin type III domain;
237-318 9.55e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 9.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370    237 DPPLGLHMEVTDDGNLKISWDsqtmAPFPLQ-----YQVKYLENSTIVREAAEIVS--ATSLLVDSVLPGSSYEVQVRSK 309
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWT----PPPDGNgpitgYEVEYRPKNSGEPWNEITVPgtTTSVTLTGLKPGTEYEVRVQAV 76


                  ....*....
gi 8567370    310 RLDGSGVWS 318
Cdd:pfam00041  77 NGGGEGPPS 85
 
Name Accession Description Interval E-value
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 429-531 3.52e-42

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 149.03  E-value: 3.52e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370    429 NINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHP--TSEPKNCVLQRDGFYECVFQPIFLLSG 506
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLADSKVNLRYRRSELSCEDRSTSSLkgGSMVKECDCQGPGFYECTIQPLYLNST 80

                          90       100
                  ....*....|....*....|....*
gi 8567370    507 YTMWIRINHSLGSLDSPPTCVLPDS 531
Cdd:pfam18589  81 YIMWLEISHGLGPLQSPPMSVKPID 105
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 126-231 1.36e-21

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 90.48  E-value: 1.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370    126 NWDIECWMKGDLTLFICHMEPLPKNPFKnyDSKVHLLYDLPEV-IDDSPLPPLKDSFQTVQCNCSL-RGCECHVPVPRak 203
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLA--DSKVNLRYRRSELsCEDRSTSSLKGGSMVKECDCQGpGFYECTIQPLY-- 76

                          90       100
                  ....*....|....*....|....*...
gi 8567370    204 LNYALLMYLEITSAGVSFQSPLMSLQPM 231
Cdd:pfam18589  77 LNSTYIMWLEISHGLGPLQSPPMSVKPI 104
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 327-418 1.59e-18

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 81.13  E-value: 1.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370    327 TTQDVVYFPPKIlTSVGSNASFHCIYKN---ENQIISSKQIVWWRNLaEKIPEIQYSIVSDRVSKVTFSNLKATRPrgkf 403
Cdd:pfam06328   1 EPCGHISPSPPV-VRLGSNVTASCILKEnccSHLGVEAQIIVWKLGL-ELIPGSQYTVLNDTVSSVTLPNLNSTRA---- 74

                          90
                  ....*....|....*.
gi 8567370    404 tydAVYCCNE-QACHH 418
Cdd:pfam06328  75 ---LLTCCLLwGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 236-328 2.54e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 2.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370  236 PDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQ-YQVKYLE--NSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 312
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgYVVEYREkgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                        90
                ....*....|....*.
gi 8567370  313 GsgvWSDWSSPQVFTT 328
Cdd:cd00063  81 G---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 236-315 3.78e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 3.78e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370     236 PDPPLGLHMEVTDDGNLKISWDSQTMAP---FPLQYQVKYLENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 312
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 8567370     313 GSG 315
Cdd:smart00060  81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 737-818 1.62e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 1.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370     737 SAVESLSAYPLSSSCVILSWTLSPDDYSLLYlVIEWKILNEDDGMKWLRIPSNVKK-FYIHDNFIPIEKYQFSLYPVFME 815
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGY-IVGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 8567370     816 GVG 818
Cdd:smart00060  81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
233-409 2.16e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 2.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370  233 VVKPDPPLGLHMEVTDDGNLKISWDSQTmAPFPLQYQVKY-LENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKrl 311
Cdd:COG3401 324 LTPPAAPSGLTATAVGSSSITLSWTASS-DADVTGYNVYRsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV-- 400

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370  312 DGSGVWSDWSSPqVFTTQDVVYFPPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVS-DRVSKVT 390
Cdd:COG3401 401 DAAGNESAPSEE-VSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTtTSSTVTA 479

                       170
                ....*....|....*....
gi 8567370  391 FSNLKATRPRGKFTYDAVY 409
Cdd:COG3401 480 TTTDTTTANLSVTTGSLVG 498
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 737-820 6.06e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.48  E-value: 6.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370  737 SAVESLSAYPLSSSCVILSWTLSPDDYSLL--YlVIEWKILNEDDGMKWLRIPSNVKKFYIhDNFIPIEKYQFSLYPVFM 814
Cdd:cd00063   2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPItgY-VVEYREKGSGDWKEVEVTPGSETSYTL-TGLKPGTEYEFRVRAVNG 79


                ....*.
gi 8567370  815 EGVGKP 820
Cdd:cd00063  80 GGESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 535-625 7.81e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 7.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370  535 PLPPSNVKAEITVNTGLLkVSWEKPVFPENNLQ-FQIRYGLSGKEiQWKTHEVFDAKSKSASL--LVSDlcAVYVVQVRC 611
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVT-LSWTPPEDDGGPITgYVVEYREKGSG-DWKEVEVTPGSETSYTLtgLKPG--TEYEFRVRA 76

                        90
                ....*....|....
gi 8567370  612 RRLDGLGYWSNWSS 625
Cdd:cd00063  77 VNGGGESPPSESVT 90
fn3 pfam00041
Fibronectin type III domain;
237-318 9.55e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 9.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567370    237 DPPLGLHMEVTDDGNLKISWDsqtmAPFPLQ-----YQVKYLENSTIVREAAEIVS--ATSLLVDSVLPGSSYEVQVRSK 309
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWT----PPPDGNgpitgYEVEYRPKNSGEPWNEITVPgtTTSVTLTGLKPGTEYEVRVQAV 76


                  ....*....
gi 8567370    310 RLDGSGVWS 318
Cdd:pfam00041  77 NGGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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