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Conserved domains on  [gi|160298207|ref|NP_034452|]
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dihydroxyacetone phosphate acyltransferase [Mus musculus]

Protein Classification

glycerol-3-phosphate acyltransferase( domain architecture ID 13250295)

glycerol-3-phosphate acyltransferase catalyzes the incorporation of an acyl group from acylCoA into the acceptor glycerol 3-phosphate

CATH:  3.40.1130.10
EC:  2.3.1.15
Gene Ontology:  GO:0004366|GO:0006072|GO:0016020|GO:0008654
PubMed:  9515909|18931347|18287005
SCOP:  3000661

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 133-338 1.94e-103

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


:

Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 313.74  E-value: 1.94e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 133 FSKVCVNEEGIQKLQRAVQE-HPVVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDFLGMrVVSELLRMSGAFFMRRT 211
Cdd:cd07993    1 FDGVQVNEGQLERLRKAAQEgHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIP-ILGTLLRRLGAFFIRRS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 212 FGGNKLYWAVFSEYVKTMLRCGYaPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESL 291
Cdd:cd07993   80 FGKDPLYRAVLQEYVQELLKNGQ-PLEFFIEGTRSRTGKLLPPKLGLLSVVVEAYLKGSVPDVLIVPVSISYDRVLEEEL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 160298207 292 YAYEILGVPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSLAA 338
Cdd:cd07993  159 YAEELLGPPKPKESLSGLLGASKILRENFGRIRVDFGEPISLREYLG 205
PlsB super family cl30506
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
 74-642 4.67e-103

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


The actual alignment was detected with superfamily member COG2937:

Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 329.58  E-value: 4.67e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  74 VLSSEEINYVIKQLSRESLTGVDVLREEASEILEEMSHKLRIGAIRFFAFVLSKIFKQIFSKVCVNeeGIQKLQRAVQEH 153
Cdd:COG2937  126 LLRSPAVRKAIEEEAKSKGISEEKARKEARRYLREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD--NLERLRELAKGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 154 PVVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGmDFLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRCG 233
Cdd:COG2937  204 EIVYVPCHRSHMDYLLLSYVLYHNGLVPPHIAAG-INLNFWPLGPILRRGGAFFIRRSFKGNKLYSAVFREYLAELFERG 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 234 YaPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYEILGVPKPKESTTGLLKAR 313
Cdd:COG2937  283 Y-SVEYFIEGGRSRTGRLLPPKTGMLSMTVQAFLRGARRPVVFVPVYIGYERVLEVGSYAKELRGGEKKKESLGGLLRAL 361

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 314 RILSENFGSIHVYFGDPVSLRSLAagrlnrNTYNLVPRCIPQKQPEDVQAFVTEVAYK-MQllQIENLA-LSPWLLVVTI 391
Cdd:COG2937  362 RKLRRRFGRVYVNFGEPISLSEYL------DQHVPDWRESEDLRPEWLRPAVDKLAFEiMV--RINRAAaVNPVNLVALA 433

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 392 LLQN-QLSMDFDALVEKtlwLKGVTQVFGGFLLWPDNKLPEEVVQssillhSNLASLVKDQVVLKMNSGSSQVVngLVPE 470
Cdd:COG2937  434 LLASpKRALTEAELLAQ---LDLYLDLLRNVPYSLSVTLPELTPE------ELLEHLLSLGLIEVEKDGLGDVI--SIDD 502

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 471 HIALLMcSAYRNQLLNIFARPSLVALALHMTPGLRKEDVFSCFSFLRNVFSDEFIFLPGNTLRD-FEEGCYLLCKAEAMQ 549
Cdd:COG2937  503 EQAVLL-TYYRNNILHLFALPALIASALLANRRISRAELLELVRLLYPLLKAELFLRWDAEFEEvLDEELDELVRQGLLE 581

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 550 MAGKDIILTDKGTAVLQFLTSLFKPFVESYQLLCRYLLHE-EDYFGEKEYLVAARKFTRQLLDQGSSQCYDALSSELQKN 628
Cdd:COG2937  582 REGDTLRRPPARFRQLQLLAHVLRETLERYAIVLSLLAKLgSGTLDRKELEKESLLLAQRLSLLHGINAPEFFDKALFRN 661

                        570
                 ....*....|....
gi 160298207 629 ALAAFVRLGVVEKK 642
Cdd:COG2937  662 FIQTLREQGYLDDD 675
 
Name Accession Description Interval E-value
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 133-338 1.94e-103

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 313.74  E-value: 1.94e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 133 FSKVCVNEEGIQKLQRAVQE-HPVVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDFLGMrVVSELLRMSGAFFMRRT 211
Cdd:cd07993    1 FDGVQVNEGQLERLRKAAQEgHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIP-ILGTLLRRLGAFFIRRS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 212 FGGNKLYWAVFSEYVKTMLRCGYaPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESL 291
Cdd:cd07993   80 FGKDPLYRAVLQEYVQELLKNGQ-PLEFFIEGTRSRTGKLLPPKLGLLSVVVEAYLKGSVPDVLIVPVSISYDRVLEEEL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 160298207 292 YAYEILGVPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSLAA 338
Cdd:cd07993  159 YAEELLGPPKPKESLSGLLGASKILRENFGRIRVDFGEPISLREYLG 205
PlsB COG2937
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
 74-642 4.67e-103

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 329.58  E-value: 4.67e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  74 VLSSEEINYVIKQLSRESLTGVDVLREEASEILEEMSHKLRIGAIRFFAFVLSKIFKQIFSKVCVNeeGIQKLQRAVQEH 153
Cdd:COG2937  126 LLRSPAVRKAIEEEAKSKGISEEKARKEARRYLREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD--NLERLRELAKGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 154 PVVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGmDFLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRCG 233
Cdd:COG2937  204 EIVYVPCHRSHMDYLLLSYVLYHNGLVPPHIAAG-INLNFWPLGPILRRGGAFFIRRSFKGNKLYSAVFREYLAELFERG 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 234 YaPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYEILGVPKPKESTTGLLKAR 313
Cdd:COG2937  283 Y-SVEYFIEGGRSRTGRLLPPKTGMLSMTVQAFLRGARRPVVFVPVYIGYERVLEVGSYAKELRGGEKKKESLGGLLRAL 361

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 314 RILSENFGSIHVYFGDPVSLRSLAagrlnrNTYNLVPRCIPQKQPEDVQAFVTEVAYK-MQllQIENLA-LSPWLLVVTI 391
Cdd:COG2937  362 RKLRRRFGRVYVNFGEPISLSEYL------DQHVPDWRESEDLRPEWLRPAVDKLAFEiMV--RINRAAaVNPVNLVALA 433

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 392 LLQN-QLSMDFDALVEKtlwLKGVTQVFGGFLLWPDNKLPEEVVQssillhSNLASLVKDQVVLKMNSGSSQVVngLVPE 470
Cdd:COG2937  434 LLASpKRALTEAELLAQ---LDLYLDLLRNVPYSLSVTLPELTPE------ELLEHLLSLGLIEVEKDGLGDVI--SIDD 502

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 471 HIALLMcSAYRNQLLNIFARPSLVALALHMTPGLRKEDVFSCFSFLRNVFSDEFIFLPGNTLRD-FEEGCYLLCKAEAMQ 549
Cdd:COG2937  503 EQAVLL-TYYRNNILHLFALPALIASALLANRRISRAELLELVRLLYPLLKAELFLRWDAEFEEvLDEELDELVRQGLLE 581

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 550 MAGKDIILTDKGTAVLQFLTSLFKPFVESYQLLCRYLLHE-EDYFGEKEYLVAARKFTRQLLDQGSSQCYDALSSELQKN 628
Cdd:COG2937  582 REGDTLRRPPARFRQLQLLAHVLRETLERYAIVLSLLAKLgSGTLDRKELEKESLLLAQRLSLLHGINAPEFFDKALFRN 661

                        570
                 ....*....|....
gi 160298207 629 ALAAFVRLGVVEKK 642
Cdd:COG2937  662 FIQTLREQGYLDDD 675
PTZ00374 PTZ00374
dihydroxyacetone phosphate acyltransferase; Provisional
 41-524 4.80e-76

dihydroxyacetone phosphate acyltransferase; Provisional


Pssm-ID: 240389 [Multi-domain]  Cd Length: 1108  Bit Score: 264.43  E-value: 4.80e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207   41 RRHISDFKFAMKC-YTPPLYRG-ITPCKPGDIKSIVLSSEEINYVIKQLS-RESLTGVDVlREEASEILEEMSHKLRIGA 117
Cdd:PTZ00374  513 RKYFDDVVWTQRVgLTANGWRFaATPGLTPESLTSILAQPSIQRLMTALAkKEGASEKDV-EARAKAILRTCGDNLNHVQ 591

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  118 IRFFAFVLSKIFKQIFSKVCVNEEGIQKLQRAVQEhP---VVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDFLGMR 194
Cdd:PTZ00374  592 CRLFGLMVRRILFRLYDRVSLNSGAFERLHRYVAM-PrvaVVLLPLHRSYIDFIIMTYLLAVMGLPLPHVCAGDDFLRMG 670

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  195 VVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRcGYAPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFF--KREVF 272
Cdd:PTZ00374  671 PIATLMRGSGAFFMRRSFRDDPLYAALFKEYVRHLVL-RRRPLEFFIEGTRSRTGKTMAPKLGLLKFICDTFYegQQELD 749

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  273 DTYFVPISISYDKILEESLYAYEILGVPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSL---------------- 336
Cdd:PTZ00374  750 DVLIIPVSLSYDELLETTLYAKEQLGVSKPKENPGNLLRARSLLKRRHGKIHVHIGEPVSLRSFkdhplqcplpfepkge 829

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  337 --AAGRLNRNTYNLVPRCiPQKQPEDVQAFVT-EVAYKMQllqiENLALSPWLLVVTILlqNQLS-----MDFDALVEKT 408
Cdd:PTZ00374  830 atTSVCKTLDTTPSIARK-SSITPPRVLTNIAwHLTHKLQ----RNTIITPTALVAAVL--ECLGptagaMPLAEVQQGM 902

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  409 LWLKGVTQVFGGFLLWPDNKL-PEEVVQSSIllhSNLASLVkdQVVLKMnsGSSQVVNGLVPEHIALLMCSayrNQLLNI 487
Cdd:PTZ00374  903 TWLRTNIRRRGAALSDDCANLnPETMVRKAL---THLQEFV--EITDEM--SEVIYVRQDVVTRLGVNICS---NQLIHV 972

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 160298207  488 FARPSLVALALHM-----TPG--LR-KEDVFS--CfSFLRNVFSDEF 524
Cdd:PTZ00374  973 FMDEAVVAVVARAfgevtAPHrvRRvEADVLKeqC-QLLRQLLSAEF 1018
PRK04974 PRK04974
glycerol-3-phosphate 1-O-acyltransferase PlsB;
74-495 7.40e-62

glycerol-3-phosphate 1-O-acyltransferase PlsB;


Pssm-ID: 235325 [Multi-domain]  Cd Length: 818  Bit Score: 220.87  E-value: 7.40e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  74 VLSSEEINYVIKQLSRESLTGVDVLREEASEILEEMSHKLRIGAIRFFAFVLSKIFKQIFSKVCV-NEEGIQKLqrAVQE 152
Cdd:PRK04974 224 LLASPAIKKAIEDEAKSKKISHEKARQNAIAYMDEIAADYSYSAIRLADRFLTWLWNRLYQGINVhNAERVRQL--AQDG 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 153 HPVVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDfLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRC 232
Cdd:PRK04974 302 HEIVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGIN-LNFWPAGPIFRRGGAFFIRRSFKGNKLYSTVFREYLGELFAR 380

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 233 GYaPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYEILGVPKPKESTTGLLKA 312
Cdd:PRK04974 381 GY-SVEYFVEGGRSRTGRLLQPKTGMLAMTLQAMLRGSRRPITLVPVYIGYEHVMEVGTYAKELRGAPKEKESLFQVLRG 459

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 313 RRILSeNFGSIHVYFGDPVSLrslaAGRLNRN--TYNLVPRCIPQKQPEDVQAFVTEVAYKMQllqiENL----ALSPWL 386
Cdd:PRK04974 460 IRKLR-NFGQGYVNFGEPIPL----NDYLNQHvpEWRESIDPIEEQRPAWLTPAVNNLANQVM----VRInnaaAANPVN 530

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 387 LVVTILLQN-QLSMDFDALVEK-TLWLKGVTQV-FGGFLLWPDNKlPEEVVQSSILLhsNLASLVKDqvvlkmNSGSsqV 463
Cdd:PRK04974 531 LCALALLASrQRALDREQLIEQlDLYLQLLRNVpYSSDTTVPEGS-GEELIDHALSL--NKFEVEKD------TLGD--I 599

                        410       420       430
                 ....*....|....*....|....*....|..
gi 160298207 464 VNglVPEHIALLMcSAYRNQLLNIFARPSLVA 495
Cdd:PRK04974 600 IS--LDREQAVLM-TYYRNNILHLFVLPSLIA 628
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 137-282 1.39e-28

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 110.83  E-value: 1.39e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  137 CVNEEGIQKLQRavqEHPVVLLPSHRSYIDFLMLSFILYSYDLPvPVIAAGMDFLGMRVVSELLRMSGAFFMRRtfgGNK 216
Cdd:pfam01553   1 RIEVHGLENLPR---GGPAIVVANHQSYLDVLLLSLALYKRGRP-LVFVAKKELFDIPLVGWLMRLLGCIFIDR---KNR 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160298207  217 LYWAVFSEYVKTMLRCGYaPVEFFLEGTRSRAAKTLTPKFGLLNIVMEpffkrevFDTYFVPISIS 282
Cdd:pfam01553  74 KDAAGTLEYLVELLREGK-LVVIFPEGTRSREGELLPFKKGAFRLAIE-------AGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 155-284 1.22e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 84.71  E-value: 1.22e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207   155 VVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDFLgMRVVSELLRMSGAFFMRRTFGgnKLYWAVFSEYVKtMLRCGY 234
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFY-VPLLGWLLRLLGAIFIDRSNG--RKARAALREAVE-LLKEGE 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 160298207   235 aPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPffkrevfDTYFVPISISYD 284
Cdd:smart00563  77 -WLLIFPEGTRSRPGKLLPFKKGAARLALEA-------GVPIVPVAIRGT 118
GPAT_C pfam19277
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal ...
 292-643 2.46e-17

Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal region of Glycerol-3-phosphate acyltransferase.


Pssm-ID: 466024  Cd Length: 370  Bit Score: 84.11  E-value: 2.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  292 YAYEILGVPKPKESTTGLLK-ARRILSENFGSIHVYFGDPVSLRSLaagrlnrntynLVPRCIPQKQPEDVQ-AFVTEVA 369
Cdd:pfam19277   1 YAAELLGGPKKPEGLSWLLSyARSQLSLKLGRVYVRFGEPWSLREF-----------LDEQGDRPATDAARRrLALQKLA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  370 YKMqLLQIeNLA--LSPWLLVVTILL--------QNQLSMDFDALVEktlWL--KGVTQvfGGFLLWPDnklpEEVVQSS 437
Cdd:pfam19277  70 FEV-LSRI-NRVtpVMPTALVGTVLLtlrgraltLSELIRRVEWLLD---YIraRGGPV--AHFGDLRT----EEVVDRA 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  438 illhsnLASLVKDQVVLKMNSGsSQVVNGLVPE--HIAllmcSAYRNQLLNIFARPSLVALALHMTP-----GLRKEDVF 510
Cdd:pfam19277 139 ------LDVLGNAGLVTRVDGG-PEPVYYIAPEdhFQA----SFYRNMTIHLFVERAIVELALLTKVkaaqrGDSYEALW 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  511 SCFSFLRNVFSDEFIFLPGNTLR-DFEEGCYLLCKAEAMQMAGKDIILTDKGTAVLQFLTSLFKPFVESYQLLCRYLLHE 589
Cdd:pfam19277 208 DQVLRLRDLLKFEFFFPPKEGFReNLRAELDLLDPWEDRVITGERDIERLLGRENPDFACFLLWPFIEAYWLVADSLADL 287

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 160298207  590 EDY--FGEKEYLVAARKFTRQLLDQGSSQCYDALSSELQKNALAAFVRLGVVEKKK 643
Cdd:pfam19277 288 TPDawIDEKDFQDEALGLGKQLYLQGRLSSFESVSKELFKNALQLAENRGLLEVSR 343
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 113-337 4.40e-08

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 54.25  E-value: 4.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 113 LRIGAIRFFAFVLSKIFKQIFSKVCVneEGIQKLQRavqEHPVVLLPSHRSYIDFLMLSFIlysydLPVPV-IAAGMDFL 191
Cdd:COG0204    8 LRRFRYRLVRLWARLLLRLLGVRVRV--EGLENLPA---DGPVLIVANHQSWLDILLLLAA-----LPRPVrFVAKKELF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 192 GMRVVSELLRMSGAFFMRRTFGGNKLywAVFsEYVKTMLRCGYAPVeFFLEGTRSRAAKTLTPKFGLLNIVMEpffkrev 271
Cdd:COG0204   78 KIPLLGWLLRALGAIPVDRSKRRAAL--RAL-RQAVEALKAGESLV-IFPEGTRSPDGRLLPFKTGAARLALE------- 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160298207 272 FDTYFVPISISYdkileeSLYAYEILGVPKPkesttgllkarrilsenfGSIHVYFGDPVSLRSLA 337
Cdd:COG0204  147 AGVPIVPVAIDG------TERALPKGFLPRP------------------GKVTVRIGPPIDPSDLE 188
 
Name Accession Description Interval E-value
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 133-338 1.94e-103

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 313.74  E-value: 1.94e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 133 FSKVCVNEEGIQKLQRAVQE-HPVVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDFLGMrVVSELLRMSGAFFMRRT 211
Cdd:cd07993    1 FDGVQVNEGQLERLRKAAQEgHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIP-ILGTLLRRLGAFFIRRS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 212 FGGNKLYWAVFSEYVKTMLRCGYaPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESL 291
Cdd:cd07993   80 FGKDPLYRAVLQEYVQELLKNGQ-PLEFFIEGTRSRTGKLLPPKLGLLSVVVEAYLKGSVPDVLIVPVSISYDRVLEEEL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 160298207 292 YAYEILGVPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSLAA 338
Cdd:cd07993  159 YAEELLGPPKPKESLSGLLGASKILRENFGRIRVDFGEPISLREYLG 205
PlsB COG2937
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
 74-642 4.67e-103

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 329.58  E-value: 4.67e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  74 VLSSEEINYVIKQLSRESLTGVDVLREEASEILEEMSHKLRIGAIRFFAFVLSKIFKQIFSKVCVNeeGIQKLQRAVQEH 153
Cdd:COG2937  126 LLRSPAVRKAIEEEAKSKGISEEKARKEARRYLREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD--NLERLRELAKGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 154 PVVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGmDFLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRCG 233
Cdd:COG2937  204 EIVYVPCHRSHMDYLLLSYVLYHNGLVPPHIAAG-INLNFWPLGPILRRGGAFFIRRSFKGNKLYSAVFREYLAELFERG 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 234 YaPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYEILGVPKPKESTTGLLKAR 313
Cdd:COG2937  283 Y-SVEYFIEGGRSRTGRLLPPKTGMLSMTVQAFLRGARRPVVFVPVYIGYERVLEVGSYAKELRGGEKKKESLGGLLRAL 361

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 314 RILSENFGSIHVYFGDPVSLRSLAagrlnrNTYNLVPRCIPQKQPEDVQAFVTEVAYK-MQllQIENLA-LSPWLLVVTI 391
Cdd:COG2937  362 RKLRRRFGRVYVNFGEPISLSEYL------DQHVPDWRESEDLRPEWLRPAVDKLAFEiMV--RINRAAaVNPVNLVALA 433

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 392 LLQN-QLSMDFDALVEKtlwLKGVTQVFGGFLLWPDNKLPEEVVQssillhSNLASLVKDQVVLKMNSGSSQVVngLVPE 470
Cdd:COG2937  434 LLASpKRALTEAELLAQ---LDLYLDLLRNVPYSLSVTLPELTPE------ELLEHLLSLGLIEVEKDGLGDVI--SIDD 502

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 471 HIALLMcSAYRNQLLNIFARPSLVALALHMTPGLRKEDVFSCFSFLRNVFSDEFIFLPGNTLRD-FEEGCYLLCKAEAMQ 549
Cdd:COG2937  503 EQAVLL-TYYRNNILHLFALPALIASALLANRRISRAELLELVRLLYPLLKAELFLRWDAEFEEvLDEELDELVRQGLLE 581

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 550 MAGKDIILTDKGTAVLQFLTSLFKPFVESYQLLCRYLLHE-EDYFGEKEYLVAARKFTRQLLDQGSSQCYDALSSELQKN 628
Cdd:COG2937  582 REGDTLRRPPARFRQLQLLAHVLRETLERYAIVLSLLAKLgSGTLDRKELEKESLLLAQRLSLLHGINAPEFFDKALFRN 661

                        570
                 ....*....|....
gi 160298207 629 ALAAFVRLGVVEKK 642
Cdd:COG2937  662 FIQTLREQGYLDDD 675
PTZ00374 PTZ00374
dihydroxyacetone phosphate acyltransferase; Provisional
 41-524 4.80e-76

dihydroxyacetone phosphate acyltransferase; Provisional


Pssm-ID: 240389 [Multi-domain]  Cd Length: 1108  Bit Score: 264.43  E-value: 4.80e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207   41 RRHISDFKFAMKC-YTPPLYRG-ITPCKPGDIKSIVLSSEEINYVIKQLS-RESLTGVDVlREEASEILEEMSHKLRIGA 117
Cdd:PTZ00374  513 RKYFDDVVWTQRVgLTANGWRFaATPGLTPESLTSILAQPSIQRLMTALAkKEGASEKDV-EARAKAILRTCGDNLNHVQ 591

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  118 IRFFAFVLSKIFKQIFSKVCVNEEGIQKLQRAVQEhP---VVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDFLGMR 194
Cdd:PTZ00374  592 CRLFGLMVRRILFRLYDRVSLNSGAFERLHRYVAM-PrvaVVLLPLHRSYIDFIIMTYLLAVMGLPLPHVCAGDDFLRMG 670

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  195 VVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRcGYAPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFF--KREVF 272
Cdd:PTZ00374  671 PIATLMRGSGAFFMRRSFRDDPLYAALFKEYVRHLVL-RRRPLEFFIEGTRSRTGKTMAPKLGLLKFICDTFYegQQELD 749

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  273 DTYFVPISISYDKILEESLYAYEILGVPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSL---------------- 336
Cdd:PTZ00374  750 DVLIIPVSLSYDELLETTLYAKEQLGVSKPKENPGNLLRARSLLKRRHGKIHVHIGEPVSLRSFkdhplqcplpfepkge 829

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  337 --AAGRLNRNTYNLVPRCiPQKQPEDVQAFVT-EVAYKMQllqiENLALSPWLLVVTILlqNQLS-----MDFDALVEKT 408
Cdd:PTZ00374  830 atTSVCKTLDTTPSIARK-SSITPPRVLTNIAwHLTHKLQ----RNTIITPTALVAAVL--ECLGptagaMPLAEVQQGM 902

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  409 LWLKGVTQVFGGFLLWPDNKL-PEEVVQSSIllhSNLASLVkdQVVLKMnsGSSQVVNGLVPEHIALLMCSayrNQLLNI 487
Cdd:PTZ00374  903 TWLRTNIRRRGAALSDDCANLnPETMVRKAL---THLQEFV--EITDEM--SEVIYVRQDVVTRLGVNICS---NQLIHV 972

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 160298207  488 FARPSLVALALHM-----TPG--LR-KEDVFS--CfSFLRNVFSDEF 524
Cdd:PTZ00374  973 FMDEAVVAVVARAfgevtAPHrvRRvEADVLKeqC-QLLRQLLSAEF 1018
PRK04974 PRK04974
glycerol-3-phosphate 1-O-acyltransferase PlsB;
74-495 7.40e-62

glycerol-3-phosphate 1-O-acyltransferase PlsB;


Pssm-ID: 235325 [Multi-domain]  Cd Length: 818  Bit Score: 220.87  E-value: 7.40e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  74 VLSSEEINYVIKQLSRESLTGVDVLREEASEILEEMSHKLRIGAIRFFAFVLSKIFKQIFSKVCV-NEEGIQKLqrAVQE 152
Cdd:PRK04974 224 LLASPAIKKAIEDEAKSKKISHEKARQNAIAYMDEIAADYSYSAIRLADRFLTWLWNRLYQGINVhNAERVRQL--AQDG 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 153 HPVVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDfLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRC 232
Cdd:PRK04974 302 HEIVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGIN-LNFWPAGPIFRRGGAFFIRRSFKGNKLYSTVFREYLGELFAR 380

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 233 GYaPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYEILGVPKPKESTTGLLKA 312
Cdd:PRK04974 381 GY-SVEYFVEGGRSRTGRLLQPKTGMLAMTLQAMLRGSRRPITLVPVYIGYEHVMEVGTYAKELRGAPKEKESLFQVLRG 459

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 313 RRILSeNFGSIHVYFGDPVSLrslaAGRLNRN--TYNLVPRCIPQKQPEDVQAFVTEVAYKMQllqiENL----ALSPWL 386
Cdd:PRK04974 460 IRKLR-NFGQGYVNFGEPIPL----NDYLNQHvpEWRESIDPIEEQRPAWLTPAVNNLANQVM----VRInnaaAANPVN 530

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 387 LVVTILLQN-QLSMDFDALVEK-TLWLKGVTQV-FGGFLLWPDNKlPEEVVQSSILLhsNLASLVKDqvvlkmNSGSsqV 463
Cdd:PRK04974 531 LCALALLASrQRALDREQLIEQlDLYLQLLRNVpYSSDTTVPEGS-GEELIDHALSL--NKFEVEKD------TLGD--I 599

                        410       420       430
                 ....*....|....*....|....*....|..
gi 160298207 464 VNglVPEHIALLMcSAYRNQLLNIFARPSLVA 495
Cdd:PRK04974 600 IS--LDREQAVLM-TYYRNNILHLFVLPSLIA 628
PRK03355 PRK03355
glycerol-3-phosphate 1-O-acyltransferase;
95-630 2.81e-48

glycerol-3-phosphate 1-O-acyltransferase;


Pssm-ID: 179567 [Multi-domain]  Cd Length: 783  Bit Score: 181.83  E-value: 2.81e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  95 VDVLREEASEILEEMSHKLRIGAIRFFAfVLSKIFKQIFS-KVCVNEEGIQKLQRAVQEHPVVLLPSHRSYIDFLMLSFI 173
Cdd:PRK03355 209 PGATVREAGKMLDELVAGWSRVSVDLVS-VLGRLFSRGFDpEIDYDEYELAALRALLEEHPAVLLFSHRSYIDGLVVPVA 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 174 LYSYDLPVPVIAAGMDfLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRCGYaPVEFFLEGTRSRAAKTLT 253
Cdd:PRK03355 288 MQENRLPPVHVFGGIN-LSFGPMGPIMRRSGMIFIRRNIGDDPLYKYVLREYVGYLVEKRF-NLSWYIEGTRSRTGKLLP 365

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 254 PKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYEILGVPKPKESTTGLLKARRILSE-NFGSIHVYFGDPVS 332
Cdd:PRK03355 366 PKLGLLSYVADAYLDGRSDDVLLQPVSISFDQLHEIGEYAAEARGGEKTPEGLRWLYNYIKAQGErNYGKIYVRFGEPVS 445

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 333 LRSlaagRLNRNTYNLVPRciPQKQPEDVQAFVTEVAYKmqLLQIENLALSPwllVVTILLqnqLSMDFDALVEKTLwlk 412
Cdd:PRK03355 446 MRQ----YLGAPHGPLTQD--PDAKRLALQKMAFEVAWR--INQVTPVTATS---LVSLLL---LGTRGRALTLDEL--- 508

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 413 gvTQVFGGFLLWPDNK-LP----------EEVVQSSILLHSNlaslvkDQVVLKMNSGSSQVVNgLVPEHiaLLMCSAYR 481
Cdd:PRK03355 509 --HHTLQDSLDYLERRqLPvstsalrlrdPEGVRAALDALSN------GGPVTRVDSGREPVWY-IAPDD--HLVAAFYR 577

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 482 NQLLNIFARPSLVALALHMTPGLRKEDVFSCF----SFLRNVFSDEFIFLPGNTLRD--FEEGCYLLCKAEAMQMAGkdi 555
Cdd:PRK03355 578 NSVIHAFLERAIVELALAAAAHVDEGDRLAAFwdqaMRLRDLLKFEFFFADSDAFRAnlRAEMAWIDPDWEDRLAAG--- 654

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 556 iltDKGTAVL----QFLTS--LFKPFVESYQLLCRYLLHEE-DYFGEKEYLVAARKFTRQLLDQGSSQCYDALSSELQKN 628
Cdd:PRK03355 655 ---GDEIDALlrakRPLMAhaMLRPFFEAYEVVADVLRDAPpDTIDEKELTALALGLGRQYVLQGRVRSSESVSTLLFAT 731


                 ..
gi 160298207 629 AL 630
Cdd:PRK03355 732 AR 733
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 137-282 1.39e-28

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 110.83  E-value: 1.39e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  137 CVNEEGIQKLQRavqEHPVVLLPSHRSYIDFLMLSFILYSYDLPvPVIAAGMDFLGMRVVSELLRMSGAFFMRRtfgGNK 216
Cdd:pfam01553   1 RIEVHGLENLPR---GGPAIVVANHQSYLDVLLLSLALYKRGRP-LVFVAKKELFDIPLVGWLMRLLGCIFIDR---KNR 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160298207  217 LYWAVFSEYVKTMLRCGYaPVEFFLEGTRSRAAKTLTPKFGLLNIVMEpffkrevFDTYFVPISIS 282
Cdd:pfam01553  74 KDAAGTLEYLVELLREGK-LVVIFPEGTRSREGELLPFKKGAFRLAIE-------AGVPIVPVAIS 131
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 133-347 2.06e-24

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 100.95  E-value: 2.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 133 FSKVCVNEEGIQKLQRAVQEH-----PVVLLPSHRSYIDFLMLSFILYsYDLPVPVIAAGMDFLGMRVvsELLRMSGAFF 207
Cdd:cd06551    1 FRYLLLNFFGFVRLEVKGPPPppgggPVLFVSNHSSWWDGLILFLLLE-RGLRRDVYGLMDEELLERY--PFFTRLGAFS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 208 MRRTFGGnklYWAVFSEYVKTMLRCGYAPVEFFLEGTRSRAAK-TLTPKFGLLNIvmepffkREVFDTYFVPISISYDKI 286
Cdd:cd06551   78 VDRDSPR---SAAKSLKYVARLLSKPGSVVWIFPEGTRTRRDKrPLQFKPGVAHL-------AEKAGVPIVPVALRYTFE 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 160298207 287 LEeslyayeilgvpkpkesttgllkarrilsENFGSIHVYFGDPVSLRSLAAGRLNRNTYN 347
Cdd:cd06551  148 LF-----------------------------EQFPEIFVRIGPPIPYAETALGEELAAELA 179
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 155-284 1.22e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 84.71  E-value: 1.22e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207   155 VVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDFLgMRVVSELLRMSGAFFMRRTFGgnKLYWAVFSEYVKtMLRCGY 234
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFY-VPLLGWLLRLLGAIFIDRSNG--RKARAALREAVE-LLKEGE 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 160298207   235 aPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPffkrevfDTYFVPISISYD 284
Cdd:smart00563  77 -WLLIFPEGTRSRPGKLLPFKKGAARLALEA-------GVPIVPVAIRGT 118
PRK11915 PRK11915
lysophospholipid acyltransferase;
78-630 1.73e-17

lysophospholipid acyltransferase;


Pssm-ID: 237022 [Multi-domain]  Cd Length: 621  Bit Score: 86.54  E-value: 1.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  78 EEINYVIKQLSRESltgvDVLREEASEILEEM--SHKLR-IGAIRFFAFVLSKIFKqifskVCVNEEGIQKLQRAVQEHP 154
Cdd:PRK11915  46 ERLRALADELGRDP----DSVRAEAAGYLREMaaSLDERaVQAWRGFSRWLMRAYD-----VLVDEDQITQLRKLDRKAT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 155 VVLLPSHRSYIDFLMLSFILYSYDLpVPVIAAGMDFLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRcGY 234
Cdd:PRK11915 117 LAFAFSHRSYLDGMLLPEVILANRL-SPALTFGGANLNFFPMGAWAKRTGAIFIRRQTKDIPVYRFVLRAYAAQLVQ-NH 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 235 APVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYEILGVPKPKESTTGLLKARR 314
Cdd:PRK11915 195 VNLTWSIEGGRTRTGKLRPPVFGILRYITDAVDEIDGPEVYLVPTSIVYDQLHEVEAMTTEAYGAVKRPEDLRFLVRLAR 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 315 ILSENFGSIHVYFGDPVSLRSlaagRLNRntynlvPRCIPQKQPEDVQAFVTEVAYKMqllqieNLA--LSPWLLVVTIL 392
Cdd:PRK11915 275 QQGERLGRAYLDFGEPLPLRK----RLQE------LRADKSGTGSEIERIALDVEHRI------NRAtpVTPTAVVSLAL 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 393 LQNQLSMDFDALVEKTLWLKGVTQVFGgfllWPDNKLPEEVVQSSIllHSNLASLVKDQVVLKMNSGSSQVVNGLVPEHi 472
Cdd:PRK11915 339 LGADRSLSISEVLATVRPLASYIAARN----WAVAGAADLTNRSTI--RWTLHQMVASGVVSVYDAGTEAVWGIGEDQH- 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 473 alLMCSAYRNQLLNIFARPSLVALALHMTPGLRKE------DVFSCFSFLRNVFSDEFIFlPGNTL--RDFEEGCYLLCK 544
Cdd:PRK11915 412 --LVAAFYRNTAIHILVDRAIAELALLAAAETTTNgsvspaTVRDEALSLRELLKFEFLF-SGRAQfeKDLANEVRLIGS 488

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 545 AEAMQMA-GKDIILTDKGTAVLQFLTSLFKPFVESYQLLC-RYLLHEEDYFGEKEYLVAARKFTRQLLDQGSSQCYDALS 622
Cdd:PRK11915 489 VVDTSKAaAAADVWRLLESADLLLAHLVLRPFLDAYHIVAdRLAAHEDDSFDEEGFLAECLQVGKQWELQRRIASAESRS 568


                 ....*...
gi 160298207 623 SELQKNAL 630
Cdd:PRK11915 569 MELFKTAL 576
GPAT_C pfam19277
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal ...
 292-643 2.46e-17

Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal region of Glycerol-3-phosphate acyltransferase.


Pssm-ID: 466024  Cd Length: 370  Bit Score: 84.11  E-value: 2.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  292 YAYEILGVPKPKESTTGLLK-ARRILSENFGSIHVYFGDPVSLRSLaagrlnrntynLVPRCIPQKQPEDVQ-AFVTEVA 369
Cdd:pfam19277   1 YAAELLGGPKKPEGLSWLLSyARSQLSLKLGRVYVRFGEPWSLREF-----------LDEQGDRPATDAARRrLALQKLA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  370 YKMqLLQIeNLA--LSPWLLVVTILL--------QNQLSMDFDALVEktlWL--KGVTQvfGGFLLWPDnklpEEVVQSS 437
Cdd:pfam19277  70 FEV-LSRI-NRVtpVMPTALVGTVLLtlrgraltLSELIRRVEWLLD---YIraRGGPV--AHFGDLRT----EEVVDRA 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  438 illhsnLASLVKDQVVLKMNSGsSQVVNGLVPE--HIAllmcSAYRNQLLNIFARPSLVALALHMTP-----GLRKEDVF 510
Cdd:pfam19277 139 ------LDVLGNAGLVTRVDGG-PEPVYYIAPEdhFQA----SFYRNMTIHLFVERAIVELALLTKVkaaqrGDSYEALW 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207  511 SCFSFLRNVFSDEFIFLPGNTLR-DFEEGCYLLCKAEAMQMAGKDIILTDKGTAVLQFLTSLFKPFVESYQLLCRYLLHE 589
Cdd:pfam19277 208 DQVLRLRDLLKFEFFFPPKEGFReNLRAELDLLDPWEDRVITGERDIERLLGRENPDFACFLLWPFIEAYWLVADSLADL 287

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 160298207  590 EDY--FGEKEYLVAARKFTRQLLDQGSSQCYDALSSELQKNALAAFVRLGVVEKKK 643
Cdd:pfam19277 288 TPDawIDEKDFQDEALGLGKQLYLQGRLSSFESVSKELFKNALQLAENRGLLEVSR 343
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 113-337 4.40e-08

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 54.25  E-value: 4.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 113 LRIGAIRFFAFVLSKIFKQIFSKVCVneEGIQKLQRavqEHPVVLLPSHRSYIDFLMLSFIlysydLPVPV-IAAGMDFL 191
Cdd:COG0204    8 LRRFRYRLVRLWARLLLRLLGVRVRV--EGLENLPA---DGPVLIVANHQSWLDILLLLAA-----LPRPVrFVAKKELF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 192 GMRVVSELLRMSGAFFMRRTFGGNKLywAVFsEYVKTMLRCGYAPVeFFLEGTRSRAAKTLTPKFGLLNIVMEpffkrev 271
Cdd:COG0204   78 KIPLLGWLLRALGAIPVDRSKRRAAL--RAL-RQAVEALKAGESLV-IFPEGTRSPDGRLLPFKTGAARLALE------- 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160298207 272 FDTYFVPISISYdkileeSLYAYEILGVPKPkesttgllkarrilsenfGSIHVYFGDPVSLRSLA 337
Cdd:COG0204  147 AGVPIVPVAIDG------TERALPKGFLPRP------------------GKVTVRIGPPIDPSDLE 188
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 154-344 1.19e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 49.19  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 154 PVVLLPSHRSYIDFLMLSFILYSYdlPVPVIAAgmDFLGMRVVSELLRMSGAFFMRRtfGGNKLYWAVFsEYVKTMLRCG 233
Cdd:cd07989   25 PVIIVANHQSYLDPLVLGAALPRP--IRFVAKK--ELFKIPFLGWLLRLLGAIPIDR--GNGRSAREAL-REAIEALKEG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160298207 234 YAPVeFFLEGTRSRAAKTLTPKFGLLNIVMEpfFKREVfdtyfVPISISydkileeslYAYEILGVPKPKESttgllkar 313
Cdd:cd07989   98 ESVV-IFPEGTRSRDGELLPFKSGAFRLAKE--AGVPI-----VPVAIS---------GTWGSLPKGKKLPR-------- 152

                        170       180       190
                 ....*....|....*....|....*....|.
gi 160298207 314 rilsenFGSIHVYFGDPVSLRSLAAGRLNRN 344
Cdd:cd07989  153 ------PGRVTVRIGEPIPPEGLELAEEDRK 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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