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Conserved domains on  [gi|171846283|ref|NP_034347|]
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CCN family member 2 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 198-241 2.67e-19

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 465952  Cd Length: 44  Bit Score: 80.07  E-value: 2.67e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 171846283  198 CLVQTTEWSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPC 241
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 252-344 1.47e-14

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member pfam00007:

Pssm-ID: 473907  Cd Length: 105  Bit Score: 68.97  E-value: 1.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171846283  252 GKKCIRTPKiakPVKFELSGCTSVKTYRAKFC-GVCT-------DGR-------CCTPHRTTTLPVEFKCPDGEIMKKNM 316
Cdd:pfam00007   1 RKKCIPTNY---TISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTY 77

                          90       100
                  ....*....|....*....|....*...
gi 171846283  317 MFIKTCACHyNCPGDNDIFESLYYRKMY 344
Cdd:pfam00007  78 PVALSCHCG-NCPTDNSDCTRLSLQPDS 104
VWC smart00214
von Willebrand factor (vWF) type C domain;
102-161 4.28e-08

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 49.44  E-value: 4.28e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 171846283   102 CVFGGSVYRSGESFQSSCKYQCTCLDGA-VGCVPL-CSmdvrlPSPDCPFPRRVKLPGKCCE 161
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
IGFBP pfam00219
Insulin-like growth factor binding protein;
40-81 1.32e-07

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 47.70  E-value: 1.32e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 171846283   40 PHCPAGVslVLDGCGCCRVCAKQLGELCTERD-PCDphKGLFC 81
Cdd:pfam00219  15 PGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 198-241 2.67e-19

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 80.07  E-value: 2.67e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 171846283  198 CLVQTTEWSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPC 241
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 252-344 1.47e-14

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 68.97  E-value: 1.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171846283  252 GKKCIRTPKiakPVKFELSGCTSVKTYRAKFC-GVCT-------DGR-------CCTPHRTTTLPVEFKCPDGEIMKKNM 316
Cdd:pfam00007   1 RKKCIPTNY---TISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTY 77

                          90       100
                  ....*....|....*....|....*...
gi 171846283  317 MFIKTCACHyNCPGDNDIFESLYYRKMY 344
Cdd:pfam00007  78 PVALSCHCG-NCPTDNSDCTRLSLQPDS 104
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 260-329 1.03e-12

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 62.81  E-value: 1.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171846283   260 KIAKPVKFELSGCTSVkTYRAKFC-GVCTD------------GRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCACHY 326
Cdd:smart00041   1 KSPVRQTITYNGCTSV-TVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79


                   ...
gi 171846283   327 NCP 329
Cdd:smart00041  80 NCP 82
VWC smart00214
von Willebrand factor (vWF) type C domain;
102-161 4.28e-08

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 49.44  E-value: 4.28e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 171846283   102 CVFGGSVYRSGESFQSSCKYQCTCLDGA-VGCVPL-CSmdvrlPSPDCPFPRRVKLPGKCCE 161
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 102-162 1.27e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.80  E-value: 1.27e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 171846283  102 CVFGGSVYRSGESFQSSCKYQCTCLDGAVGCvplcsMDVRLPSPDCPFPRRVKLPGKCCEE 162
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLC-----DKIICPPLDCPNPRLEIPPGECCPV 56
IGFBP pfam00219
Insulin-like growth factor binding protein;
40-81 1.32e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 47.70  E-value: 1.32e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 171846283   40 PHCPAGVslVLDGCGCCRVCAKQLGELCTERD-PCDphKGLFC 81
Cdd:pfam00219  15 PGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 40-92 2.91e-06

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 44.38  E-value: 2.91e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 171846283    40 PHCPAGVslVLDGCGCCRVCAKQLGELCT-ERDPCdpHKGLFCDFGSPANRKIG 92
Cdd:smart00121  16 PGCAELV--RLDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGEERPLR 65
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 201-242 2.35e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 2.35e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 171846283   201 QTTEWSACSKTCGMGISTRV--------TNDNTFCR-LEKQSRLCMVRPCE 242
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPCP 53
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 198-241 2.67e-19

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 80.07  E-value: 2.67e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 171846283  198 CLVQTTEWSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPC 241
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 252-344 1.47e-14

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 68.97  E-value: 1.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171846283  252 GKKCIRTPKiakPVKFELSGCTSVKTYRAKFC-GVCT-------DGR-------CCTPHRTTTLPVEFKCPDGEIMKKNM 316
Cdd:pfam00007   1 RKKCIPTNY---TISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTY 77

                          90       100
                  ....*....|....*....|....*...
gi 171846283  317 MFIKTCACHyNCPGDNDIFESLYYRKMY 344
Cdd:pfam00007  78 PVALSCHCG-NCPTDNSDCTRLSLQPDS 104
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 260-329 1.03e-12

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 62.81  E-value: 1.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171846283   260 KIAKPVKFELSGCTSVkTYRAKFC-GVCTD------------GRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCACHY 326
Cdd:smart00041   1 KSPVRQTITYNGCTSV-TVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79


                   ...
gi 171846283   327 NCP 329
Cdd:smart00041  80 NCP 82
VWC smart00214
von Willebrand factor (vWF) type C domain;
102-161 4.28e-08

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 49.44  E-value: 4.28e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 171846283   102 CVFGGSVYRSGESFQSSCKYQCTCLDGA-VGCVPL-CSmdvrlPSPDCPFPRRVKLPGKCCE 161
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 102-162 1.27e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.80  E-value: 1.27e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 171846283  102 CVFGGSVYRSGESFQSSCKYQCTCLDGAVGCvplcsMDVRLPSPDCPFPRRVKLPGKCCEE 162
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLC-----DKIICPPLDCPNPRLEIPPGECCPV 56
IGFBP pfam00219
Insulin-like growth factor binding protein;
40-81 1.32e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 47.70  E-value: 1.32e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 171846283   40 PHCPAGVslVLDGCGCCRVCAKQLGELCTERD-PCDphKGLFC 81
Cdd:pfam00219  15 PGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 40-92 2.91e-06

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 44.38  E-value: 2.91e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 171846283    40 PHCPAGVslVLDGCGCCRVCAKQLGELCT-ERDPCdpHKGLFCDFGSPANRKIG 92
Cdd:smart00121  16 PGCAELV--RLDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGEERPLR 65
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 203-241 1.30e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.49  E-value: 1.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 171846283  203 TEWSACSKTCGMGISTRV-------TNDNTFCRLEKQSRLCMVRPC 241
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRTrtvivepQNGGRPCPELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 201-242 2.35e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 2.35e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 171846283   201 QTTEWSACSKTCGMGISTRV--------TNDNTFCR-LEKQSRLCMVRPCE 242
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPCP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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