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Conserved domains on  [gi|6678115|ref|NP_033290|]
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cornifin-A [Mus musculus]

Protein Classification

Cornifin domain-containing protein( domain architecture ID 12034798)

Cornifin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 4-142 3.58e-41

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


:

Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 134.03  E-value: 3.58e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115      4 HQQKQPCTVPPQlhqqqvkQPCQPPPQEPCAPKTKDPCHP-VPEPCNPKGPEPCHPKAPEPCHPKAPEPCNPKVPEPCQP 82
Cdd:pfam02389   3 QQVKQPCQPPPQ-------EPCVPTTKEPCHSKVPEPCNPkVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCYP 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115     83 KVPEPCQPKVPEPCNPKVPEPCQPKAPEPCHPKAPEPCHPVVPEPCPSTVTPSPYQQKTK 142
Cdd:pfam02389  76 KVPEPCSPKVPEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVTPGPAQQKTK 135
 
Name Accession Description Interval E-value
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 4-142 3.58e-41

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 134.03  E-value: 3.58e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115      4 HQQKQPCTVPPQlhqqqvkQPCQPPPQEPCAPKTKDPCHP-VPEPCNPKGPEPCHPKAPEPCHPKAPEPCNPKVPEPCQP 82
Cdd:pfam02389   3 QQVKQPCQPPPQ-------EPCVPTTKEPCHSKVPEPCNPkVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCYP 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115     83 KVPEPCQPKVPEPCNPKVPEPCQPKAPEPCHPKAPEPCHPVVPEPCPSTVTPSPYQQKTK 142
Cdd:pfam02389  76 KVPEPCSPKVPEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVTPGPAQQKTK 135
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
62-127 3.52e-12

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 62.51  E-value: 3.52e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6678115    62 EPCHPKAPEPCNPKVPEPCqpkVPEPCQpkvPEPCNPKVPEPCQPKAPEPcHPKAPEPCHPVVPEP 127
Cdd:PRK15313 559 EPDEPIIPDPVDPVIPDPV---IPDPVD---PDPVDPVIPDPVIPDPVDP-DPVDPEPVDPVIPDP 617
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 59-144 2.88e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 36.91  E-value: 2.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115    59 KAPEPCHPKAPE-------PCNPKVPEPC-QPKVPEPcQPKVPEPcNPKVPEPCQPKAPEPCHPKAPEPCHPVVPEPCPS 130
Cdd:NF033838 397 KAEEEAKRKAAEedkvkekPAEQPQPAPApQPEKPAP-KPEKPAE-QPKAEKPADQQAEEDYARRSEEEYNRLTQQQPPK 474

                         90
                 ....*....|....*
gi 6678115   131 TVTPS-PYQQKTKQK 144
Cdd:NF033838 475 TEKPAqPSTPKTGWK 489
 
Name Accession Description Interval E-value
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 4-142 3.58e-41

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 134.03  E-value: 3.58e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115      4 HQQKQPCTVPPQlhqqqvkQPCQPPPQEPCAPKTKDPCHP-VPEPCNPKGPEPCHPKAPEPCHPKAPEPCNPKVPEPCQP 82
Cdd:pfam02389   3 QQVKQPCQPPPQ-------EPCVPTTKEPCHSKVPEPCNPkVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCYP 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115     83 KVPEPCQPKVPEPCNPKVPEPCQPKAPEPCHPKAPEPCHPVVPEPCPSTVTPSPYQQKTK 142
Cdd:pfam02389  76 KVPEPCSPKVPEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVTPGPAQQKTK 135
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
62-127 3.52e-12

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 62.51  E-value: 3.52e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6678115    62 EPCHPKAPEPCNPKVPEPCqpkVPEPCQpkvPEPCNPKVPEPCQPKAPEPcHPKAPEPCHPVVPEP 127
Cdd:PRK15313 559 EPDEPIIPDPVDPVIPDPV---IPDPVD---PDPVDPVIPDPVIPDPVDP-DPVDPEPVDPVIPDP 617
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
46-126 9.42e-11

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 58.66  E-value: 9.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115    46 EPCNPKGPEPCHPKAPEPCHPKA--PEPCNPKVPEPCQPKVPEPcQPKVPEPCNPKVPEPCQPKAPEPCHPKAPEpcHPV 123
Cdd:PRK15313 559 EPDEPIIPDPVDPVIPDPVIPDPvdPDPVDPVIPDPVIPDPVDP-DPVDPEPVDPVIPDPTIPDIGQSDTPPITE--HQF 635


                 ...
gi 6678115   124 VPE 126
Cdd:PRK15313 636 RPE 638
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
35-102 2.96e-09

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 54.03  E-value: 2.96e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6678115    35 PKTKDPCHPV-PEPC--NPKGPEPCHPKAPEPCHPKAPEPcNPKVPEPCQPKVPEPCQPKVPEPCNPKVPE 102
Cdd:PRK15313 563 PIIPDPVDPViPDPVipDPVDPDPVDPVIPDPVIPDPVDP-DPVDPEPVDPVIPDPTIPDIGQSDTPPITE 632
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
86-136 5.82e-08

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 50.57  E-value: 5.82e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6678115    86 EPCQPKVPEPCNPKVPEPCQPKapepchPKAPEPCHPVVPEPC-PSTVTPSP 136
Cdd:PRK15313 559 EPDEPIIPDPVDPVIPDPVIPD------PVDPDPVDPVIPDPViPDPVDPDP 604
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 43-134 6.06e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 38.91  E-value: 6.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115     43 PVPEPCNPKGPEPCHPKAPEPCHPKA----PEPCNPKVPEPCQPKVPEPCQPKVPEPCNPKVPEP--CQPKAPEPCHPKA 116
Cdd:PRK10263  751 PVQQPQQPVAPQQQYQQPQQPVAPQPqyqqPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPqyQQPQQPVAPQPQY 830

                          90
                  ....*....|....*...
gi 6678115    117 PEPCHPVVPEPCPSTVTP 134
Cdd:PRK10263  831 QQPQQPVAPQPQDTLLHP 848
PHA03247 PHA03247
large tegument protein UL36; Provisional
 43-137 1.05e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.00  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115     43 PVPEPCNPKGPEPCHPKA---PEPCHPKAPEPCNPKVPEPCQPKVPEPCQPKVPEPCNPKVPEPCQPKAPEPCHPKAPEP 119
Cdd:PHA03247 2866 PPSRSPAAKPAAPARPPVrrlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945

                          90
                  ....*....|....*...
gi 6678115    120 CHPVVPEPCPSTVTPSPY 137
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQPW 2963
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 43-129 1.06e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 37.87  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115    43 PVPEPCNPKGPEPChPKAPEPCHPKAPEPCNPKVPEPCQPKVPEPCQPKV-PEPCNPKVPEPcQPKAPEPCHPKAPEPCH 121
Cdd:PRK14950 364 PAPQPAKPTAAAPS-PVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVpPRPVAPPVPHT-PESAPKLTRAAIPVDEK 441


                 ....*...
gi 6678115   122 PVVPEPCP 129
Cdd:PRK14950 442 PKYTPPAP 449
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 59-144 2.88e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 36.91  E-value: 2.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115    59 KAPEPCHPKAPE-------PCNPKVPEPC-QPKVPEPcQPKVPEPcNPKVPEPCQPKAPEPCHPKAPEPCHPVVPEPCPS 130
Cdd:NF033838 397 KAEEEAKRKAAEedkvkekPAEQPQPAPApQPEKPAP-KPEKPAE-QPKAEKPADQQAEEDYARRSEEEYNRLTQQQPPK 474

                         90
                 ....*....|....*
gi 6678115   131 TVTPS-PYQQKTKQK 144
Cdd:NF033838 475 TEKPAqPSTPKTGWK 489
PHA03247 PHA03247
large tegument protein UL36; Provisional
 50-141 3.57e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 36.45  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115     50 PKGPEPCHPKAPEpcHPKAPEPCNPKVPEPCQPKVPEPCQPKVPEPCNPKVPEPCQPKAPEPCHPKAPEPCHPVVPEPCP 129
Cdd:PHA03247 2867 PSRSPAAKPAAPA--RPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLA 2944

                          90
                  ....*....|..
gi 6678115    130 STVTPSPYQQKT 141
Cdd:PHA03247 2945 PTTDPAGAGEPS 2956
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 66-126 4.88e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 36.04  E-value: 4.88e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6678115    66 PKAPEPCNPKVPEPCQPKVPEPCQPKVPEPCNPKVPEPCQPKAPEPCHPKAPEPCHPVVPE 126
Cdd:PRK01297  16 QPAPAPPSPAAAPAPPPPAKTAAPATKAAAPAAAAPRAEKPKKDKPRRERKPKPASLWKLE 76
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 42-138 5.45e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 35.85  E-value: 5.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678115    42 HPVPEPCNPKGPEPCHPKA-PEPCHPKAPEPCNPKVPEPCQPKVPEPCQPKVPEPCNPKVPEPCQPKAPEPCHPKAPEPC 120
Cdd:PRK14951 392 APVAQAAAAPAPAAAPAAAaSAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPA 471

                         90
                 ....*....|....*...
gi 6678115   121 HPVVPEPCPSTVTPSPYQ 138
Cdd:PRK14951 472 VASAAPAPAAAPAAARLT 489
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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