|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
106-504 |
0e+00 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 625.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYSMLLEEE-KEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGA 184
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtKLGDPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 185 AVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIK 264
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 265 LAQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSKRGAHTLRQRFLVQFRKYFNMRVFRQRTYRIWAFGIAAAALGYFVP 344
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRTLHSRINLFLRKIFNVEIFKRKRYVIWALGIPLALFGYFVP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 345 YVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCL 424
Cdd:cd17420 241 YVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKMYLQVLSFVSIGLMSMMIPLCNSFGILISVCL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 425 FLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVP 504
Cdd:cd17420 321 VMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFFIP 400
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
106-504 |
0e+00 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 614.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYSMLL-EEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGA 184
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLnEQEDQKDQAVQFKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 185 AVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIK 264
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 265 LAQTFQVLSTFMFVLTLLSLTYRpllpssqdtpskrgahtlrqrflvqfrkyfnmrVFRQRTYRIWAFGIAAAALGYFVP 344
Cdd:cd17465 161 LAHTFQVLSLFMFIQIFLSLTYK---------------------------------VFRRKTYRIWAFGIATAVLGYFVP 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 345 YVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCL 424
Cdd:cd17465 208 YVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGDLIPGLKKIYLQVASFLLLGIMSMMIPLCQVFEGVIVVCL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 425 FLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVP 504
Cdd:cd17465 288 FLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLFFVP 367
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
106-504 |
2.74e-174 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 497.39 E-value: 2.74e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYSMLLEE-EKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGA 184
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEfGSKDDAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 185 AVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIK 264
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 265 LAQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSKRGahtlRQRFLvQFRKYFNMRVFRQRTYRIWAFGIAAAALGYFVP 344
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKKR----KFKCP-PLKKIFNFNIWKSTGYRIWAFGIPAALFGYFVP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 345 YVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCL 424
Cdd:cd17464 236 YVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIPGVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 425 FLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVP 504
Cdd:cd17464 316 FMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIILCFIP 395
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
106-504 |
3.93e-103 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 314.49 E-value: 3.93e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYSMLLEEekekNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAA 185
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEE----FGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 186 VAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKL 265
Cdd:cd17352 77 LAALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 266 AQTFQVLSTFMFVLTLLSLTyrpllpssqdtpskrgahtlrqrflvqfrkyfnMRVFRQRTYRIWAFGIAAAALGYFVPY 345
Cdd:cd17352 157 RGALLILGGLCLNLCVCGLL---------------------------------LRLLKDPTFVLLALGVSFAMLGFFVPF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 346 VHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSiPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLF 425
Cdd:cd17352 204 VYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADK-PRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVL 282
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 112421075 426 LGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVP 504
Cdd:cd17352 283 FGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
92-519 |
2.80e-54 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 189.95 E-value: 2.80e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 92 RGTARGFQPPEGGFGWIVVFAATWCNGSIFGIHNSVGILYsmlleeekeKNRQVEFQA-----AWVGALAMGMIFFCSPI 166
Cdd:TIGR00892 3 PALPPEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFF---------KELQQIFQAtysetAWISSIMLAVLYAGGPI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 167 VSIFTDRLGCRITATTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSS 246
Cdd:TIGR00892 74 SSILVNRFGCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 247 IFSMSFPFLIKMLGDKIKLAQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSK---------RGAHTLRQRFLVQFRKYF 317
Cdd:TIGR00892 154 VFLSTLAPLNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKskeglppdgSTKKLSKKSTAEKINRFL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 318 NMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISdsipGLKKI---- 393
Cdd:TIGR00892 234 DFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIA----GLKWIrphv 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 394 -YLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIA 472
Cdd:TIGR00892 310 qYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLA 389
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 112421075 473 GLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRDSS 519
Cdd:TIGR00892 390 GRLVDATKNYKYIFYASGSIVVSAGLFLAIGNYINYRLLAKEQKAAL 436
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
106-504 |
1.80e-43 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 158.71 E-value: 1.80e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVefqaAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAA 185
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRV----SWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 186 VAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKL 265
Cdd:cd17423 77 LSSLGFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 266 AQTFQVLSTFMFVLTLLSLTYRPLlpssqdtpskrgahTLRQRFLVQFRKY---FNMRVFRQRTYRIWAFGIAAAALGYF 342
Cdd:cd17423 157 RGALLLLSALSLHLVPCGALLRPL--------------ALPGDPPAPPRSLsaaFGLSLLTHRAFLRYALATTLINTGYF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 343 VPYVHLMKYVEDK-FKEIKETWVLLVcIGATSGLGRLVSGHISDSIPgLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIV 421
Cdd:cd17423 223 IPYVHLVAHARALgLGEYQAAFVVSV-AAVADAVGRLFSGWLADLGP-LRLLHLLVLWTALTGLSLLLLPLAKVYGSLLA 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 422 VCLFLGLCDGffitIMAPIAF----ELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGA 497
Cdd:cd17423 301 LAVAYGFCAG----ALAPLVFsvlpELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGS 376
|
....*..
gi 112421075 498 VILFFVP 504
Cdd:cd17423 377 LILLTLP 383
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
106-500 |
2.17e-36 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 139.09 E-value: 2.17e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYSMLLEEekeknrqveFQA-----AWVGALAMGMIFFCSPIVSIFTDRLGCRITA 180
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMRE---------FGVgysdtAWISSILLAMLYGTGPLCSILVNRFGCRPVM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 181 TTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLG 260
Cdd:cd17430 72 LVGGLLASLGMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 261 DKIKLAQTFQVLSTFMFVLTLLSLTYRPLlpssqdtpskrgahtlrqrflvqfrkyfNMRVFRQRTYRIWAFGIAAAALG 340
Cdd:cd17430 152 EEYGWRGGFLILGGLLLNCCTCGAVMRPL----------------------------DFSVFRDRGFVIYTIAKFIMVLG 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 341 YFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISdsipGLKKI-----YLQVLSFLLLGLMSMMIPLCRD 415
Cdd:cd17430 204 LFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVA----GLKWVrprvvYLFSFAMLFNGLTDLCSATAAD 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 416 FGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPII 495
Cdd:cd17430 280 YGGLVVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVL 359
|
....*
gi 112421075 496 GAVIL 500
Cdd:cd17430 360 SALFL 364
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
106-487 |
5.98e-34 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 132.20 E-value: 5.98e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYSMLleeekeknrQVEFQA-----AWVGALAMGMIFFCSPIVSIFTDRLGCRITA 180
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDL---------QKEFQAsnsetSWFPSIMTAVLHAGGPLCSILVERFGCRVTV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 181 TTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLG 260
Cdd:cd17425 72 MLGGLLSGVGMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 261 DKIKLAQTFQVLSTFMFVLTLLSLTYRPLlpssqdtpskrgahtlrqrflvqfrkyfnmrvFRQRTYRIWAFGIAAAALG 340
Cdd:cd17425 152 EEMGWRGSFLVFGGVLLNCCVCGAVMRPF--------------------------------CSNTRYQIYTLGVTWMVLG 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 341 YFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISD-SIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGL 419
Cdd:cd17425 200 FVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGlPVFKGRRIYLFSLALLLNGLSNLICAISASFPVL 279
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112421075 420 IVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFY 487
Cdd:cd17425 280 LVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFY 347
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
106-504 |
3.77e-30 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 121.48 E-value: 3.77e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEKeknrQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAA 185
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQ----QSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 186 VAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKL 265
Cdd:cd17429 77 LTSLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 266 AQTfqvlstfMFVLTLLSLTYrpllpssqdtpSKRGAHtlrqrflvqfrkyfnMRVFRQRTYRIWAFGIAAAALGYFVPY 345
Cdd:cd17429 157 RNA-------MFIQGAVSLNL-----------CVCGAL---------------MRLFTNKVFVAFIFWALFAYCSFVIPF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 346 VHLMKYVED-KFKEIKETWVLLVCIGATSGLGRLVSGHISDsIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCL 424
Cdd:cd17429 204 IHLPEIVKLyGLSEQNDKFPLTSIIAIVHIFGKVILGIICD-LPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCA 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 425 FLGLCDGFFiTIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVP 504
Cdd:cd17429 283 LIGFSSGYF-SLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICLLLKP 361
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
106-503 |
1.43e-29 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 119.85 E-value: 1.43e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVefqaAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAA 185
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRV----SWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 186 VAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKL 265
Cdd:cd17422 77 LISLGMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 266 AQTFQVLSTFMFVLTLLsltyrpllpssqdtpskrGAHtlrqrflvqfrkyfnMRVFRQRTYRIWAFGIAAAALGYFVPY 345
Cdd:cd17422 157 RYCLLVVGALQLNIVVC------------------GAL---------------LRVLKEPGFICYALFGLFATLGFFAPQ 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 346 VHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPgLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLF 425
Cdd:cd17422 204 LYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCP-IRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIF 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 426 LGLCDGFFITIMAPIAFE--LVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFV 503
Cdd:cd17422 283 YGFMFGTVAGTHIPLLAEddVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLALV 362
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
106-501 |
1.83e-28 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 116.90 E-value: 1.83e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYsmllEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAA 185
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFF----KEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGC 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 186 VAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKL 265
Cdd:cd17426 77 LSGAGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 266 AQTFQVLSTFMFVLTLLSLTYRPLLPssqdtpskrgahtlrqrflvqfRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPY 345
Cdd:cd17426 157 RGSFLILGGLLLNCCVAGSLMRPIGP----------------------KPFLDLTLFTHRGFLLYLSGNVIMFFGLFAPL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 346 VHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKI-YLQVLSFLLLGLMSMMIPLCRDFGGLIVVCL 424
Cdd:cd17426 215 VFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIqYFFAASVLYNGVCHLLAPLSTSYVGFCIYAI 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 112421075 425 FLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILF 501
Cdd:cd17426 295 FFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYLF 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
107-504 |
9.77e-28 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 114.98 E-value: 9.77e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 107 WIVVFAATWCNGSIFGIHNSVGILYSMLLEEekeknrqveF-----QAAWVGALAMGMIFFCSPIVSIFTDRLGCRITAT 181
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEE---------FglsaaQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 182 TGAAVAFIGLhTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYF-QRRLGLANGVVSA----GSSIFSMSFPFLI 256
Cdd:COG2223 75 IGLLLLGIGL-LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGggnlGAAVAAFLAPLLI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 257 KMLGdkikLAQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSKRGAHTLRQrflvqfrkyfnmrVFRQRTYRIWAFGIAA 336
Cdd:COG2223 154 AAFG----WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE-------------ALRDPRFWLLSLLYFG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 337 AALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGA-TSGLGRLVSGHISDSIpGLKKIYLQVLSFLLLGLMSMMIPLcRD 415
Cdd:COG2223 217 TFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFAlLGALGRPLGGWLSDRI-GGRRVLLIVFALMALGLLLLALAL-GS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 416 FGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPII 495
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALV 374
|
....*....
gi 112421075 496 GAVILFFVP 504
Cdd:COG2223 375 ALVLTLLLY 383
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
106-505 |
1.29e-27 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 114.15 E-value: 1.29e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVefqaAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAA 185
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQI----SWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 186 VAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFlIKMLGDKIKL 265
Cdd:cd17421 77 LVSAGFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFALAPF-TQLLLDEYDW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 266 AQTFQVLSTFMFVLTLLSLTYRPLlpssqdtpskrgahtlrqrflvqfrkyfNMRVFRQRTYRIWAFGIAAAALGYFVPY 345
Cdd:cd17421 156 QGALLIFGGIMLNLVASGMLLRPI----------------------------DFSLLKDPFFCIYTWSFVFSQLAYFIPY 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 346 VHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSiPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLF 425
Cdd:cd17421 208 FHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQ-NWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVF 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 426 LGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPL 505
Cdd:cd17421 287 FAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLEPL 366
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
106-501 |
2.91e-27 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 112.98 E-value: 2.91e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYsmllEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAA 185
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFF----KEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 186 VAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKL 265
Cdd:cd17427 77 LCSLGMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 266 AQTFQVLSTFMFVLTLLSLTYRPLLPssqdtpskrgahtlrqrflvqfrkyfnmrVFRQRTYRIWAFGIAAAALGYFVPY 345
Cdd:cd17427 157 RGSFLILGGLLLNCCVAGSLMRPLGP-----------------------------LFKHRGFLIYLSGNVIMFLGFFAPI 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 346 VHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKI-YLQVLSFLLLGLMSMMIPLCRDFGGLIVVCL 424
Cdd:cd17427 208 VFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIqYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAV 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 112421075 425 FLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILF 501
Cdd:cd17427 288 FFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWLF 364
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
106-502 |
1.10e-25 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 108.36 E-value: 1.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKnrqvEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCR-ITATTGA 184
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEG----KGMTAWVGSLASGVGLIASPVCSACVSSFGARpVTIFSGF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 185 AVAFiGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDkik 264
Cdd:cd17428 77 MVAG-GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIE--- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 265 laqtFQVLSTFMFVLTLLSLTyrpLLPSSQDtpskrgahtlrqrflvqfrkyfnMRVFRQRTYRIWAFGIAAAALGYFVP 344
Cdd:cd17428 153 ----LYGLDGCLLIVGALALN---LLACGSL-----------------------MRLFKNRVFSALFIAILLFDIGAFPP 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 345 yVHLMKYVEDKFKEIKETWV--LLVCIGATSGLGRLVSGHISDsIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVV 422
Cdd:cd17428 203 -SLLMEDVARSENIIEEIALipLVSIIGITTAIGKLILGVLAD-FKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 423 CLFLGLCDGFFiTIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFF 502
Cdd:cd17428 281 SAILGFLSGNW-SIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLL 359
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
107-503 |
2.27e-25 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 108.08 E-value: 2.27e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 107 WIVVFAAtwcngsiFGIHNSVGILY--SMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGA 184
Cdd:cd17353 3 WLVLLGA-------VLMHLILGYQYawSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 185 AVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIK 264
Cdd:cd17353 76 ILFGLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 265 LAQTFQVLSTFMFVL-TLLSLTYRplLPSSQDTPSKRGAhtLRQRFLVQFRKYFNMRVFRQRTYRI--WAFGIAAAALGY 341
Cdd:cd17353 156 VPTTFLILGIIFLIIiVIGAFLIR--DPPKGWVPPGVDP--LANNAENSPRDYTPREMLRTPTFWLlwLMFFLNATAGLM 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 342 FVPYVHLMkyVEDKFKEIKETWVLLVCI-GATSGLGRLVSGHISDSIpGLKKIYLqvLSFLLLGLMSMMIPLCRDFGGLI 420
Cdd:cd17353 232 LIGQAKPI--GQEFAGLDAGIAALAVSIlSIFNGGGRPFWGWLSDKI-GRKNTLS--IAFLIQGVAMFLLPFIGSVAVLF 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 421 VVCLFL-GLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNcFGDYHVAFYFAGVPPIIGAVI 499
Cdd:cd17353 307 VLGVALiGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLY-TGGYNAAFIIAAALSLVALAL 385
|
....
gi 112421075 500 LFFV 503
Cdd:cd17353 386 ALLL 389
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
146-501 |
3.67e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 104.43 E-value: 3.67e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 146 EFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAAVAFIGLhTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVI 225
Cdd:cd06174 30 ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGA-LLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 226 LGHYF-QRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKikLAQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSKRGAHT 304
Cdd:cd06174 109 IADLFpERERGRALGLLQAFGSVGGILGPLLGGILASS--LGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEE 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 305 LRQRFLVQFRKyfnmRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEDKFK-EIKETWVLLVCIGATSGLGRLVSGHI 383
Cdd:cd06174 187 ASSKSVLKLLK----RVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 384 SDSIPGLKkiYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMAL 463
Cdd:cd06174 263 SDRLIGRK--PLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFL 340
|
330 340 350
....*....|....*....|....*....|....*...
gi 112421075 464 PMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILF 501
Cdd:cd06174 341 GGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
145-503 |
2.83e-22 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 98.34 E-value: 2.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 145 VEFQA---------AWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGC 215
Cdd:cd17424 27 VEFQNyfaqdyartAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTGLILSSFATSLEYLYLTLGVLTGLGF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 216 SFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKLAQTFQVLSTFMFVLTLLSLTYRPLLPSSqd 295
Cdd:cd17424 107 ALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRFLLMPD-- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 296 tpskrgahtlrqrflvqfrkyfnmrvfrqrtYRIWAFGIAAAALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGL 375
Cdd:cd17424 185 -------------------------------FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDII 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 376 GRLVSGHISDSiPGLKKI--YLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQA 453
Cdd:cd17424 234 GNITFGWLTDR-RCLKKYryFCYLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSA 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 112421075 454 IGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFV 503
Cdd:cd17424 313 LGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLGSA 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
119-469 |
1.77e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 89.78 E-value: 1.77e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 119 SIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAAVAFIGLHTSSFTS 198
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 199 SLSLrYFTYGILFGCGCSFAFQPSLVILGHYFQR-RLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKLAQTFQVLSTFMF 277
Cdd:pfam07690 84 SLWL-LLVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 278 VLTLLSLTYRPLLPSSQDTPSKRGAHTLRQRFlvqfrkyfnmRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEDKFK 357
Cdd:pfam07690 163 LAAVLLLLPRPPPESKRPKPAEEARLSLIVAW----------KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 358 EIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIM 437
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|..
gi 112421075 438 APIAFELVGPMQASQAIGYLLGMMALPMIAGP 469
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
106-503 |
2.88e-18 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 86.70 E-value: 2.88e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVefqaAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAA 185
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQI----ATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 186 VAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKL 265
Cdd:cd17314 77 MVLAGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 266 AQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSKrgahtlrqrflVQFRKYFNM-RVFRQRTYRIWAFGIAAAALGYF-- 342
Cdd:cd17314 157 ALVYTILGILAAIVLSVVSLLGFKEPPDNQARLH-----------VQKKKTQTMgEIFRDKVFWILFIAIFLVLIGGFlf 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 343 ----VPYVHLMKYVEDKFKEIketwvLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGG 418
Cdd:cd17314 226 ianmASLVRSLQLDAPSFVTK-----LMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 419 LIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAV 498
Cdd:cd17314 301 LVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASA 380
|
....*
gi 112421075 499 ILFFV 503
Cdd:cd17314 381 ILLAV 385
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
106-503 |
1.50e-17 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 84.63 E-value: 1.50e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 106 GWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEkeknrqvefqaAW-----VGALAMGMIFF--CSPIVSIFTDRLGCRI 178
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEF-----------GWsraviSLAFTVGLLAFglAQPFVGRLLDRFGPRR 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 179 TATTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPS-LVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIK 257
Cdd:cd17355 70 VMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 258 MLGDKIKLAQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSKRGAHTlrQRFLVQFRkyfnmRVFRQRTYRIWAFGIAAA 337
Cdd:cd17355 150 ALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASP--ASPGSTLK-----EALRSASFWLLALAFFLC 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 338 ALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPglkKIYLQVLSFLLLGLMSMMIPLCR-DF 416
Cdd:cd17355 223 GFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYS---PRRLLAASYALRALGLALLLLLPfPP 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 417 GGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIG 496
Cdd:cd17355 300 LALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIA 379
|
....*..
gi 112421075 497 AVILFFV 503
Cdd:cd17355 380 ALLVLPI 386
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
99-504 |
2.28e-16 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 80.68 E-value: 2.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 99 QPPEGGFGWIVVFAATWCNGSIFGIHNSVGILYSMLLEEekeknrqveF-----QAAWVGALAMGMIFFCSPIVSIFTDR 173
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQAD---------LglsaaQLGLLASAFFLGYALGQIPAGLLADR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 174 LGCRITATTGAAVAFIGLHTSSFTSSLSLRYFTYgILFGCGCSFAFQPSLVILGHYF-QRRLGLANGVVSAGSSIFSMSF 252
Cdd:COG2271 72 FGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 253 PFLIKMLGDKIKLAQTFQVLSTFMFVLTLLsltyrpllpssqdtpskrgahtlrqrflvqfrkyfnmrvfrqrtyRIW-- 330
Cdd:COG2271 151 PPLLGWLLAAFGWRAAFLILGLPGLLLALL---------------------------------------------RFWll 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 331 AFGIAAAALGYFVPYVHLMKYVEDKFK-EIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLqVLSFLLLGLMSMM 409
Cdd:COG2271 186 ALAYFLVYFALYGFLTWLPTYLVEVRGlSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL-AIGLLLAALALLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 410 IPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFA 489
Cdd:COG2271 265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLL 343
|
410
....*....|....*
gi 112421075 490 GVPPIIGAVILFFVP 504
Cdd:COG2271 344 AALALLAALLALLLL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
146-463 |
8.37e-15 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 75.78 E-value: 8.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 146 EFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAAVAFIGLhTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVI 225
Cdd:COG2814 44 PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS-LLCALAPSLWLLLAARFLQGLGAGALFPAALAL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 226 LGHYF-QRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKLAQTFQVLSTFMFVLTLLSLTyrpLLPSSQDTPSKRGAHT 304
Cdd:COG2814 123 IADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLR---LLPESRPAARARLRGS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 305 LRqrflvqfrkyfnmRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEDKFK-EIKETWVLLVCIGATSGLGRLVSGHI 383
Cdd:COG2814 200 LR-------------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 384 SDSIpGLKKIYlqVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMAL 463
Cdd:COG2814 267 ADRF-GRRRLL--LIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
148-503 |
2.92e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 71.44 E-value: 2.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 148 QAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAAVAFIGLHTSSFTSSLSLRYFTYgILFGCGCSFAFQPSLVILG 227
Cdd:COG2807 54 QAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGT-ALIGAGIAVGNVLLPGLIK 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 228 HYFQRRLGLANGVVSA----GSSIFSMSFPFLIKMLGDKIKLAqTFQVLSTFMFVLTLLSLTYRPllpssQDTPSKRGAH 303
Cdd:COG2807 133 RWFPDRVGLMTGLYTAamglGAALAAGLTVPLAAALGWRGALA-VWALLALLALLLWLPLLRRRP-----AAAAAAPAAA 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 304 TLRqrflvqfrkyfnmRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHI 383
Cdd:COG2807 207 SLR-------------SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 384 SDSIPGLKKIYLQVLSFLLLGLMSMMI-PLcrdfGGLIVVCLFLGLCDGF-FITIMAPIAFELVGPMQASQAIGYLLGMM 461
Cdd:COG2807 274 ADRLGDRRPLLLLLGLLGLAGLLGLLLaPG----SLPWLWAVLLGLGQGGlFPLALTLIGLRARTPAEAAALSGMAQSVG 349
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 112421075 462 ALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFV 503
Cdd:COG2807 350 YLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
371-503 |
1.57e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 68.85 E-value: 1.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 371 ATSGLGRLVSGHISDSIpGLKKIYLqvLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQA 450
Cdd:COG2814 56 LGAALGAPLAGRLADRF-GRRRVLL--LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERR 132
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 112421075 451 SQAIGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFAGVPPIIGAVILFFV 503
Cdd:COG2814 133 GRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
330-504 |
1.67e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 69.14 E-value: 1.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 330 WAFGIAAAALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIpGLKKIYlqVLSFLLLGLMSMM 409
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRF-GRKRLL--LLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 410 IPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFA 489
Cdd:cd17325 78 FAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVC 156
|
170
....*....|....*
gi 112421075 490 GVPPIIGAVILFFVP 504
Cdd:cd17325 157 AALALLALVLALLLL 171
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
146-509 |
3.02e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.34 E-value: 3.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 146 EFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAAVAFIGLhtssFTSSLSLRYFTYGI---LFGCGCSF---AF 219
Cdd:COG0738 42 DAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL----LLFALAPSYPLLLLalfLLGLGLGLldvAA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 220 QPSLVILGH-YFQRRLGLANGVVSAGSSIFSMSFPFLIKmLGDKIKLAQTFQVLSTFMFVLTLLSLTYRplLPSSQDTPS 298
Cdd:COG0738 118 NPYVAALGPeTAASRLNLLHAFFSLGALLGPLLGGLLIL-LGLSLSWHLPYLILAVLLLLLALLFLRSK--LPEIEEEEE 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 299 KRGAHTLRQRFLVQFRkyfnmrvfrqrtyRIWAFGIAA--AALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATS-GL 375
Cdd:COG0738 195 EAAGSAASLKSLLKNP-------------RLLLGGLAIflYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGmTI 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 376 GRLVSGHISDSIPGLKkiYLQVLSFLLLGLMSMMIPlcrdFGGLIVVCLFLGLCdGFFITIMAPIAFELVG---PMQASQ 452
Cdd:COG0738 262 GRFLGGFLLKRFGPVR--LLRLSALLAAVGLLLALL----APGPWLALIGLALV-GLGLSLMFPTIFSLALdglGKRTAA 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 112421075 453 AIGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYfagVPPIIGAVILFFVPLMHQR 509
Cdd:COG0738 335 AVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFL---VPLVCYLLILLLALALKRK 387
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
231-502 |
7.82e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.83 E-value: 7.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 231 QRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKLAQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSKRGAHTLRQRFL 310
Cdd:cd17325 115 PEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRL 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 311 VQFRKYFnmRVFrqrtyrIWAFGIAAAALGYFVPYVHLmkYVEDKFKEIKETWVLLV-CIGATSGLGRLVSGHISDSIPG 389
Cdd:cd17325 195 LLRDRRL--LAL------FLAIFVLAFAFGALEPFLPL--YAAELGGLSPAQIGLLFgAQGLASALSQPPAGKLSDRIGR 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 390 LKKIylqVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGP 469
Cdd:cd17325 265 KPLI---LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGP 341
|
250 260 270
....*....|....*....|....*....|...
gi 112421075 470 PIAGLLRNCFGdYHVAFYFAGVPPIIGAVILFF 502
Cdd:cd17325 342 LLGGFLYDAFG-FATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
365-524 |
4.47e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 61.28 E-value: 4.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 365 LLVCIGATSGLGRLVSGHISDSIpGLKKIYLqvLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFEL 444
Cdd:pfam07690 37 LLTLFSLGYALAQPLAGRLSDRF-GRRRVLL--IGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 445 VGPMQASQAIGYLLGMMALPMIAGPPIAGLLrNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRDSSKDKML 524
Cdd:pfam07690 114 FPPEERGRALGLVSAGFGLGAALGPLLGGLL-ASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIV 192
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
372-504 |
7.61e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 60.69 E-value: 7.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 372 TSGLGRLVSGHISDSIpGLKKIYLqvLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQAS 451
Cdd:cd17489 43 AALLARPFAGRLLDRF-GRKRLLL--IGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRG 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 112421075 452 QAIGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFAGVPPIIGAVILFFVP 504
Cdd:cd17489 120 EGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVAAVLALLALLLVFLVK 171
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
152-500 |
7.97e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 60.71 E-value: 7.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 152 VGALAMGMIFFCSPIvSIFTDRLGCRITATTG---AAVAFIGLHTSSFTSSLSLRYFTYGILFGCgcsfaFQP--SLVIL 226
Cdd:cd17475 37 LSALNLGVAVSMLPA-GWLLDRFGERRVLAVGlllMGAAALLMALVGSYPVLLVLLFLVGAGYGS-----VQPggGRAIM 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 227 GHYFQRRLGLANGV----VSAGSSIFSMSFPFLIKMLGDKIKLAqTFQVLSTFMFVLTLLSltYRPLLPSSQDTPSKRGA 302
Cdd:cd17475 111 RWFPPRERGLAMGIrqtgVPLGGALAAALLPPLALHYGWRAAFV-VAGLVSILAAVLFWLF--YREPPAASAATESASTL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 303 HTLRQRflvqfrkyfnmrVFRQRTyrIWAFGIAAAAL--GYFVPYVHLMKYVEDKFK-EIKETWVLLVCIGATSGLGRLV 379
Cdd:cd17475 188 LRSLKE------------VLRNRD--VWLIAIAGALLvaPQFALLTFLLLFLHDHLGlSVVAAGALLAVAQLGGALGRIG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 380 SGHISDSI-PGLKKIYLQVLSF---LLLGLMSMMIPLCrDFGGLIVVCLFLGL-CDGFFITIMAPIAfELVGPMQASQAI 454
Cdd:cd17475 254 LGRVSDRVfGGRRRPVLVITAAiaaAALLVLSLLSPGT-PLWLLVLLLILLGLfAIGWNGLYLTLVA-ESAGPEQAGTAL 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 112421075 455 GYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVIL 500
Cdd:cd17475 332 GLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
374-503 |
2.08e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.40 E-value: 2.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 374 GLGRLVSGHISDSIpGLKKIYLqvLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQA 453
Cdd:cd17324 48 ALGALLLGPLSDRI-ERRRLLL--VLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRA 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 112421075 454 IGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFAGVPPIIGAVILFFV 503
Cdd:cd17324 125 IGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLALLAALLLWRL 173
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
145-504 |
2.24e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.96 E-value: 2.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 145 VEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCR--------ITATTGAAVAFIglhtSSFTSSLSLRyftygILFGCGCS 216
Cdd:cd17473 33 SELLVPLLLTLPALFIALFAPLAGWLADRFGRKrlliagllLYGIGGVAGLFL----DSLYALLASR-----ALLGIGVA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 217 FAFQPSLVILGHYFQ-----RRLGLANGVVSAGSSIFSMS----------FPFLIkmlgdkiklaqtfQVLSTFMFVLTL 281
Cdd:cd17473 104 GIMTLATALIGDYFEgeeraKMLGLQSAAMSLGGVVFLLLggalaeigwrAPFLV-------------YLLALPVLILVL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 282 LSLTYRPLLPSSQDTPSKRGAHTLRQRflvqfrkyfnmRVFrqrtyrIWAFGIAAAALGYFVPYVHLMKYVEDKFK-EIK 360
Cdd:cd17473 171 LFLPEPARKSKSAASPGAATAAALPWK-----------RVL------PIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 361 ETWVLLVCIGATSGLGRLVSGHISDSIPglkKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPI 440
Cdd:cd17473 234 LIGLALAIASLAGAIGALLFGRLKRRLG---KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSW 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 112421075 441 AFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVP 504
Cdd:cd17473 311 AMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
325-501 |
2.52e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.93 E-value: 2.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 325 RTYRIWAFGIAAAALGYFvPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIpGLKKIYlqVLSFLLLG 404
Cdd:cd17370 200 KAFWLYLLAVALFALGNF-SFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRI-GRKKLL--ILGYLSLA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 405 LMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGdYHV 484
Cdd:cd17370 276 LAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-PSA 354
|
170
....*....|....*..
gi 112421075 485 AFYFAGVPPIIGAVILF 501
Cdd:cd17370 355 AFLFSAVLALIALLLLL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
147-502 |
4.03e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.23 E-value: 4.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 147 FQAAWVGALAMGMIFFCSPIVSIFTDRLGCR---ITATTGAAVAFIGLhTSSFTSSLSLRYFTYGILFGCGCSFAFQ--- 220
Cdd:cd06173 34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrllILADLLRALLAAVL-ALLALLGSLSLWLLLVLAFLLGIASAFFgpa 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 221 -----PSLVILGHyfqrrLGLANGVVSAGSSIFSMSFP----FLIKMLGdkIKLAQTFQVLSTFMFVLTLLSLTYRPLLP 291
Cdd:cd06173 113 rqallPELVPKEQ-----LVRANALNSLATQLARIIGPalggLLVALLG--PGGAFAINALSFLLSALLLLFIRRPPPAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 292 SSQDTPSKRGAhtlrqrfLVQFRKYFnmrvFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEDKFKEIKETW-VLLVCIG 370
Cdd:cd06173 186 PGESSSLLLRD-------LREGLRYL----RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYgLLLAAFG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 371 ATSGLGRLVSGHISdsiPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQA 450
Cdd:cd06173 255 VGALLGALLLGRLS---KRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELR 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 112421075 451 SQAIGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFAGVPPIIGAVILFF 502
Cdd:cd06173 332 GRVFSVYNALNSGAMPLGALLAGLLADALG-LSAVFLLAGALLLLAALLLLL 382
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
330-504 |
1.12e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 50.89 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 330 WAFGIAAAALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIpGLKKIYLqvLSFLLLGLMSMM 409
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLL--LGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 410 IPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFG-DYHVAFYF 488
Cdd:cd06174 78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfGWRAVFLI 157
|
170
....*....|....*.
gi 112421075 489 AGVPPIIGAVILFFVP 504
Cdd:cd06174 158 AAALALLAAILLLLVV 173
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
162-503 |
7.03e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 48.34 E-value: 7.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 162 FCSPIVSIFTDRLGCRITATTGAAVAFIGlhtsSFTSSLSLRYFT---YGILFGCGCSFAFQPSLVILGHYFQ-RRLGLA 237
Cdd:cd17474 49 VLMPVAGVLADRFGRKKVLLPGLLLFGIG----GLLCGLSDSFALllaGRALQGIGAAGLGPLALTLIGDLFEgGERAKA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 238 NGVVSAGSSIFSMSFPFLIKMLGDkIKLAQTFQVLSTFMFVLTLLSLTYRPllpssqdtPSKRGAHTLRQRFLVQFRKYF 317
Cdd:cd17474 125 MGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLP--------EPKEKAKSSSATKLRDLKKAL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 318 NMRvfrqrtyriWAFGIAAAALGYFVPYVHLMKY---VEDKFKEIKETW--VLLVCIGATSGLGRLVSGHISDSIPGLKK 392
Cdd:cd17474 196 RGR---------GLLTFLVSAFLYFFLYFAFLTYlpfLLELLYGISPIIigLLFAGWSVLLALGSLFVGRLLKKRFGARR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 393 IYlqVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGyLLGMMA-LPMIAGPPI 471
Cdd:cd17474 267 IL--VIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASS-LYNFVRfLGQAVGPLL 343
|
330 340 350
....*....|....*....|....*....|..
gi 112421075 472 AGLLRNCFGdYHVAFYFAGVPPIIGAVILFFV 503
Cdd:cd17474 344 FGLLLEIFG-LSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
375-503 |
1.10e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 47.57 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 375 LGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLcrdFGGLIVVCLFLGLCDGFFITIMAPIAF---ELVGPMQAS 451
Cdd:cd17319 230 IGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYL---TTSPVVAVILLSLAGFGIGAASPVFWSlpaDLLPGEAAA 306
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 112421075 452 QAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFV 503
Cdd:cd17319 307 TAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
232-502 |
3.91e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.05 E-value: 3.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 232 RRLGLANGVVSAGSSIFSMSFPFLIKMLGDkiklAQTFQVLSTFMFVLTLLSLTYRPLLPssqDTPSKrgAHTLRQRFLV 311
Cdd:cd17489 116 SRRGEGIGYYGLATTLAMALGPALGLFLYQ----HLGFAVLFIVAAVLALLALLLVFLVK---DPPPV--AAEEAEAGTR 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 312 QFRKYFNMRVFRQrtyriwAFGIAAAALGYFVPYVHLMKYVEDKFkeIKETWVLLVCIGATSGLGRLVSGHISDSIPGLK 391
Cdd:cd17489 187 AFRRLVEKKVLPP------ALILFLASIAYGAISTFLPLYAAERG--ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKT 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 392 KIYLqvlSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPI 471
Cdd:cd17489 259 VIIP---GLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLL 335
|
250 260 270
....*....|....*....|....*....|.
gi 112421075 472 AGLLRNCFGdYHVAFYFAGVPPIIGAVILFF 502
Cdd:cd17489 336 LGLVAELFG-YRAMFLLAAVVVLLALVLYIF 365
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
372-504 |
4.18e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.57 E-value: 4.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 372 TSGLGRLVSGHISDSIpGLKKIYLqvLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQAS 451
Cdd:COG0477 61 GRAIGLLLFGRLGDRY-GRKRVLL--IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERG 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 112421075 452 QAIGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFAGVPPIIGAVILFFVP 504
Cdd:COG0477 138 RALGLWGAAIGLGLALGPLLGGLLVAALG-WRWIFLINAPLGLLALVLRLRLP 189
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
148-501 |
4.84e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.62 E-value: 4.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 148 QAAWVGALAMGMIFFCSPIVSIFTDRLGcRITATTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILG 227
Cdd:cd17324 35 QAGLLVSAYALGYALGALLLGPLSDRIE-RRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 228 HYF-QRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKLAQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSKRGAHTLr 306
Cdd:cd17324 114 DLVpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLL- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 307 qrflvqfrkyfnmRVFRQRTYRiWAFGIAAAALG-------YFVPYVHLMKYVEDKFkeikeTWVLLVCIGATSGLGRLV 379
Cdd:cd17324 193 -------------LLLRNPRLR-LAYLITFLLFGgffalytYLAPFLTDVPGFSSSA-----IIGLLLLFGVAGVVGSPL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 380 SGHISDSIPGLKKIylqVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLcdGFFIT-IMAPIAFELVGPMQASQAIGYLL 458
Cdd:cd17324 254 AGRLADRGGRRALL---IALLLLAAALLLLTLLGPSPLLLLVGLVLWGL--GFFAAhSALQTRVLRLAPEARGLASSLYL 328
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 112421075 459 GMMALPMIAGPPIAGLLRNCFGdYHVAFYFAGVPPIIGAVILF 501
Cdd:cd17324 329 AAYNLGGALGAALGGLVLDHGG-WAGVGWVGAALLLLALLLAL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
149-510 |
6.18e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.66 E-value: 6.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 149 AAWVG-ALAMGMIF--FCSPIVSIFTDRLGCR--------ITATTGAAVAFIGL-HTSSFTSSLSLRYF--TYgILFGCG 214
Cdd:COG2211 45 AALVGlILLVARLWdaITDPLIGALSDRTRTRwgrrrpwiLIGAIPLALSFVLLfTAPDLSPTGKLIYAlvTY-LLLGLA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 215 CSFAFQP--SLV--ILGHYFQR-RL-GLANGVVSAGSSIFSMSFPFLIKMLGDKIklAQTFQVLSTFMFVLTLLSLtyrp 288
Cdd:COG2211 124 YTLVNIPysALGaeLTPDYEERtRLsSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALIFAVLGLLAF---- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 289 LLPSSQdTPSKRGAHTLRQRFLVQFRKyfnmrVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEDKFKEIKETW-VLLV 367
Cdd:COG2211 198 LLTFFG-TKERPVPEEEKVSLKESLKA-----LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVgLLLA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 368 CIGATSGLGRLVSGHISDSIpGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELV-- 445
Cdd:COG2211 272 LYFLAALLGAPLWPRLAKRF-GKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdy 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 446 -----GPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGD--------------YHVAFYFAGVPPIIGAVILFFVPLM 506
Cdd:COG2211 351 dewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYvagaaqspsaltgiRLLFFLLPAVLLLLAALLLLFYPLT 430
|
....
gi 112421075 507 HQRM 510
Cdd:COG2211 431 RERH 434
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
378-513 |
5.07e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.56 E-value: 5.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 378 LVSGHISDsIPGLKKIYLQVLSFLLLGlmSMMIPLCRDFGGLIVVCLFLGLCDGFFitimaPIAF----ELVGPMQASQA 453
Cdd:cd17504 49 PILGRLGD-LYGRKKVLLIVLAIYTAG--SLLAAFAPNLPVLIAGRALQGIGGAVF-----PLAFalvrEEFPPERVPVA 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 454 IGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFAGvppIIGAVILFFVPLMHQRMFKK 513
Cdd:cd17504 121 QGILSATFGIGAGIGLPLGGWIVQHLG-WRWIFWTAA---PVAVLLAALVPLIDLRLLRR 176
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
378-505 |
6.01e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.22 E-value: 6.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 378 LVSGHISDSIPglKKIYLqVLSFLLLGLMSMMIPLCRDFGGLIVVCLFL-----GLCDGFFITIMAPIAFELVGPMQASQ 452
Cdd:cd06173 52 PFAGVLADRFD--RRRLL-ILADLLRALLAAVLALLALLGSLSLWLLLVlafllGIASAFFGPARQALLPELVPKEQLVR 128
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 112421075 453 AIGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFAGVPPIIGAVILFFVPL 505
Cdd:cd06173 129 ANALNSLATQLARIIGPALGGLLVALLG-PGGAFAINALSFLLSALLLLFIRR 180
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
374-506 |
1.21e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.40 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 374 GLGRLVSGHISDSIpGLKKIYLqvLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQA 453
Cdd:cd17319 52 ALFQVPGGWLLDRF-GARKVLA--VSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRA 128
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 112421075 454 IGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFAGVPPII-GAVILFFVPLM 506
Cdd:cd17319 129 TGLFNSGAPLGAAIGPPLSGWLLLLFG-WRWAFIIEGLLGLLlAVLWWFYLRQV 181
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
373-502 |
1.37e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.05 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 373 SGLGRLVSGHISDSIPGLKKIYLqvLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQ 452
Cdd:cd17490 243 NALASLLSGTLFYKKLGERNTII--IGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRST 320
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 112421075 453 AIGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFAGVPPIIGAVILFF 502
Cdd:cd17490 321 AMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAAILSLA 369
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
389-512 |
1.43e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.02 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 389 GLKKIYLqvLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYL-LGMMALPMIa 467
Cdd:cd17503 59 GTRRLFL--TALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVgLVILLAPAI- 135
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 112421075 468 GPPIAGLLRNCFGdYHVAFYFAgVPpiIGAVILFFVPLMHQRMFK 512
Cdd:cd17503 136 GPTLGGWLTDNLS-WRWIFYIN-LP--IGILALLLAPLLDLRLFK 176
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
369-506 |
1.49e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.02 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 369 IGATSGLGRLVS----GHISDSIpGLKKIylqvlsfLLLGLMSMMIPLC-----RDFGGLIVVCLFLGLCDGFFITIMAP 439
Cdd:cd17330 39 LQSSYSLGQFLAsplwGRLSDRY-GRKPV-------LLLSLAGSAVSYVllglsRNLWLLFLARFLDGLTGGNVSVAQAY 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112421075 440 IAfELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFAGVPPIIGAV-ILFFVPLM 506
Cdd:cd17330 111 IA-DITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYG-YALPFLVAAALALLNLVlVLFFLPPL 176
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
148-503 |
3.65e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.61 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 148 QAAWVGALAMGMIFFC--------SPIVSIFTDRLGCRITATTGAAVAFIGLHTSSFTSSLSLrYFTYGILFGCGCSFAF 219
Cdd:cd17333 24 EAFNLNVADVSVIFSSqnagyligSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYL-FVVLMFLAGLGAGILD 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 220 QPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKLAQT-FQVLSTFMFVLTLL-SLTYRPLLPSSQDTP 297
Cdd:cd17333 103 TGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWaYLIIGLIYLLLAILiLLTLFPELPSARNPQ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 298 SKRGAH------TLRQRFLVQFRKYFNMRVFRQRTYRIWAFGIAAaalGYFVPYVHLMKYVEDKFkeiketWVLLVciga 371
Cdd:cd17333 183 QSVGAFsasasrLLRNPSIILGALALFLYVGAETAFSSWVPSYLV---EKKHVSDGLAGYLLSGF------WVGIT---- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 372 tsgLGRLVSGHISDSIpgLKKIYLqVLSflLLGLMSMMIPLCRDFGGliVVCLFLGLCDGFFITIMAPIAFEL---VGPM 448
Cdd:cd17333 250 ---IGRLLGGPISRRI--KPHTLL-VLS--GSGALLGLLILLLAPTL--VVGLVATALLGLFMAALFPTILSLgisNLPY 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 112421075 449 QASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYhvafYFAGVPPIIGAVILFFV 503
Cdd:cd17333 320 AKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQ----TAMLLITILYAIIFVLA 370
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
365-502 |
4.01e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.54 E-value: 4.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 365 LLVCIGATSGLGRLVSGHISDsIPGLKKIYLQVLSFLLLGLMSMMIpLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFEL 444
Cdd:cd17341 39 LVAIPVLAGALLRLPYGFLCD-RFGGRRVFIASLLLLLIPLLALAL-AVSSYWGLLVLGFLLGFAGANFASGQPWASFWF 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 112421075 445 VGPMQASQAIGYL-LGMM--ALPMIAGPPIAGLLRNCFGDY--HVAFYFAGVPPIIGAVILFF 502
Cdd:cd17341 117 PKEKIGGAAGGIAgAGNMgvAVSQLLAPLIAGAIVFDGGFVgwRNAFFVPGILLAIAAVLVLL 179
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
397-502 |
7.45e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 7.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 397 VLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLR 476
Cdd:cd17330 245 RLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLY 324
|
90 100
....*....|....*....|....*.
gi 112421075 477 NCFGdYHVAFYFAGVPPIIGAVILFF 502
Cdd:cd17330 325 SFLG-PGVPFLLAAGLLLIALFLLSL 349
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
148-288 |
7.53e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.70 E-value: 7.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 148 QAAWVGALAMGMIFFCSPIVSIFTDRLG--CRITATTGAAVAFIGLhTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVI 225
Cdd:COG2271 217 QAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALAL-LLLALLPSPALAIALLFLAGFGLGGAFGLLWAL 295
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 112421075 226 LGHYFQRRL-GLANGVVSAGSSIFSMSFPFLIKMLGDKIKLAQTFQVLSTFMFVLTLLSLTYRP 288
Cdd:COG2271 296 AAELFPKKArGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
147-501 |
9.44e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.31 E-value: 9.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 147 FQAAWVGALAMGMIFFCSPIVSIFTDR--------LGCRITATTGAAVAFIGlhtssftsslslryfTYGILF------G 212
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQPLFGYLADRkprryllpLGPLLTGLGLSLLGFAP---------------NYWLLLllvalaG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 213 CGcSFAFQP-SLVILGHYFQRRLGLANGVVSAGSSI-FSMSfPFLIKMLGDKIKLAQTFqVLSTFMFVLTLLsLTYRPLL 290
Cdd:cd17478 96 IG-SAAFHPeGARLASQAAGGRRGLAMSIFSVGGNLgFALG-PLIAAALVALFGGLGLL-ILLIIPGLAVAL-LLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 291 PSSQDTPSKRGAHTLRQRFLVQFRKYFNMRVFrqrtyrIWAFGIAAAALGYFVPYvhlmkYVEDKFKEIKETWVLLVCIG 370
Cdd:cd17478 172 LKKPEAKKAAAKSSARSTLKGVWRALLLLLII------VFLRSWVLSSLTTFLPF-----YLVQRGYSLVFAGLLLSLFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 371 ATSGLGRLVSGHISDSIpGLKKIYLqvLSFLLLGLMSMMIPLcRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVgPMQA 450
Cdd:cd17478 241 FAGAIGTLIGGPLSDRF-GRRRVII--ASLLLAAPFLLLFLL-TPGIWSYILLVLAGFLLFASFPVTVVLAQELL-PGNV 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 112421075 451 SQAIGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFAGVPPIIGAVILF 501
Cdd:cd17478 316 GLASGLMMGLSFGLGGIGAPVLGALADAFG-LESVLLILALLPLLGALLAF 365
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
370-504 |
9.78e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 9.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112421075 370 GATSGLGRLVSGHISDSIpGLKKIYLQvLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIA--FElvgP 447
Cdd:cd17490 41 GISQMLLRIPLGILSDRI-GKRKLFII-IGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYAsyFP---P 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 112421075 448 MQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGdYHVAFYFAGVPPIIGAVILFFVP 504
Cdd:cd17490 116 DEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFG-MRAPFLLAALAGVLGFILSLFIK 171
|
|
| |
