|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
12-1142 |
0e+00 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 1850.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 12 PSYTPpARSSAPHILAG---SLQAPLWLRAYFQGLLFSLGCRIQKHCGKVLFLGLVAFGALALGLRVAVIETDLEQLWVE 88
Cdd:TIGR00918 13 PSYCD-AAFALEQIDKGkatGRRAPLWLRAKFQRLLFTLGCYIQKHCGKVLFVGLLVFSAFAVGLRAANIETNVEQLWVE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 89 VGSRVSQELHYTKEKLGEEAAYTSQMLIQTAHQEGGNVLTPEALDLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLI 168
Cdd:TIGR00918 92 VGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPST 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 169 ENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPQQLLEELGPFAS-LEGFRELLDKAQVGQAY 247
Cdd:TIGR00918 172 EGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSqVESWEEMLKKAAVGQGY 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 248 VGRPCLDPDDPHCPPSAPNRHSRQAPNVAQELSGGCHGFSHKFMHWQEELLLGGTARDLQGQLLRAEALQSTFLLMSPRQ 327
Cdd:TIGR00918 252 MERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPKQ 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 328 LYEHFRGDYQTHDIGWSEEQASMVLQAWQRRFVQLAQEALPANASQQIHAFSSTTLDDILRAFSEVSTTRVVGGYLLMLA 407
Cdd:TIGR00918 332 MYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLA 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 408 YACVTMLRWDCAQSQGAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDIFLLAHAFTKAPPDTPL 487
Cdd:TIGR00918 412 YACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNIPF 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 488 PERMGECLRSTGTSVALTSVNNMVAFFMAALVPIPALRAFSLQAAIVVGCNFAAVMLVFPAILSLDLRRRHRQRLDVLCC 567
Cdd:TIGR00918 492 EERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCC 571
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 568 FSSPCSAQVIQMLPQELGDR-AVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLLSPASDPLGSELYSPGGSTRDLL 646
Cdd:TIGR00918 572 FFSPCSARVIQIEPQAYADGsAPPVYSSHMQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQPSDPLSCQSPDIAGSTRDLL 651
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 647 SQEEGTGpqAACRPLLCAHWTLAHFARYQFAPLLLQTRAKALVLLFFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAF 726
Cdd:TIGR00918 652 SQFEDSK--AACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDF 729
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 727 LSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRSWLQGIQAAFDQDWASGRIT 806
Cdd:TIGR00918 730 LDAQFRYFSFYNMYAVTQGNFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQLPRMWLHYFRDWLQGLQKAFDEDWRDGRIT 809
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 807 CHSYRNGSEDGALAYKLLIQTGNAQEPLDFSQLTTRKLVDKEGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWL 886
Cdd:TIGR00918 810 KENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAFYIYLSAWVSNDPVAYAASQANIYPHPPEWL 889
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 887 HDKYDTTGENLRIPAAQPLEFAQFPFLLHGLQKTADFVEAIEGARAACTEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLL 966
Cdd:TIGR00918 890 HDKNDYDPENLRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSYPSGYPFLFWEQYMGLRHWLLL 969
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 967 AVCILLVCTFLVCALLLLSPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASIGIGVEFTVHVALGFLTSHGS 1046
Cdd:TIGR00918 970 SISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIGD 1049
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 1047 RNLRAASALEQTFAPVTDGAVSTLLGLLMLAGSNFDFIIRYFFVVLTVLTLLGLLHGLLLLPVLLSILGPPPQVVQVYKE 1126
Cdd:TIGR00918 1050 RNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLVLLPVLLSMFGPEPEVSPAEGR 1129
|
1130
....*....|....*.
gi 6679517 1127 SPQTLNSAAPQRGGLR 1142
Cdd:TIGR00918 1130 SRLPTPSPEPPPGGVR 1145
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
418-570 |
6.19e-55 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 187.79 E-value: 6.19e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 418 CAQSQGAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDIFLLAHAFTKAPPDTPLPERMGECLRS 497
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6679517 498 TGTSVALTSVNNMVAFFMAALVPIPALRAFSLQAAIVVGCNFAAVMLVFPAILSLDLRRRHRQRLDVLCCFSS 570
Cdd:pfam12349 81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
38-1089 |
4.24e-49 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 190.89 E-value: 4.24e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 38 AYFQGLLFSL----GCRIQKHCGKVLFLGLVAFGALALGLRVAVIETDLEQLWVEVGSRVSQELHYTKEKLGeeAAYTSQ 113
Cdd:TIGR00917 303 STVQGHLARFfgkyGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFG--PFYRIE 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 114 MLIQTA-----HQEGGNVLTPEALDLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLieNGMIERMIEKLFPcviltp 188
Cdd:TIGR00917 381 QLIIATvqtssHEKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPY--NCFIYSTCKKLQN------ 452
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 189 ldcfwegaklqggsaylpgrpdiQWTNLDPQQLlEELGPFASLEGFRELLDKAQvgqayvgrPCLDpddphcppsapnrh 268
Cdd:TIGR00917 453 -----------------------MYSKLKPENY-DDYGGVDYVKYCFEHFTSPE--------SCLS-------------- 486
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 269 SRQAPnvaqelsggchgfshkfmhWQEELLLGGTARDLQGQllrAEALQSTFLLmsprqlyehfrgdyqthDIGWSEEQA 348
Cdd:TIGR00917 487 AFGGP-------------------VDPTTVLGGFSGNNFSE---ASAFVVTFPV-----------------NNFVNKTNK 527
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 349 SMVLQAWQRRFVQLAQEALPANASQQIHAFSSTTLDDILRAFSEVSTTRVVGGYLLMLAYACVTM-----LRWDCAQSQG 423
Cdd:TIGR00917 528 TEKAVAWEKAFIQLAKDELLPMVQATISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLgdsprLKSLYVTSKV 607
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 424 AVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDIFLLAHAF-----------TKAPPDTPLPERMG 492
Cdd:TIGR00917 608 LLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqvgVDNEQELTLERRLS 687
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 493 ECLRSTGTSVALTSVNNMVAFFMAALVPIPALRAFSLQAAIVVGCNFAAVMLVFPAILSLDLRRRHRQRLDVLCCFsspc 572
Cdd:TIGR00917 688 RALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCI---- 763
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 573 saqviqmlpqelgdRAVPVGIAHLTATVQAFTHCeassqhvvtilppqahllspasdplgselyspggstrdllsqeegt 652
Cdd:TIGR00917 764 --------------KTSKSSISAEKGSGQRKAGL---------------------------------------------- 783
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 653 gpqaacrpllcahwtLAHFARYQFAPLLLQTRAKALVLLFFGALLGLSLYGATLVQDGLALTDVVPRGTK-EHAFLSAQL 731
Cdd:TIGR00917 784 ---------------LTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYlQIYFASLTP 848
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 732 RYFSLYEVALVTQGGFDYAHSQ---RALFDLHQRFSSLKAVLP--PPATQAPRTWLHYYRSWLQGiQAAFDQDWASGRIT 806
Cdd:TIGR00917 849 LLEVGPPFYIVIKGDYNYTDFEsqnKLCTMGGCDKDSIVNVFNnlSYIAKPASSWLDDYLVWLSP-QASCCCRKFTNGTF 927
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 807 ChsyrNGSEDGALAYKLLIQTGNAQ-EPLDFSQlttrklvdkegLIPpelFYMGLTVWVSSDPLGLAASQanfyppppew 885
Cdd:TIGR00917 928 C----NGPDPQCFRCADLSSDAQGRpSTTQFKE-----------KLP---WFLNALPSADCAKGGHAAYS---------- 979
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 886 lhDKYDTTGENLRIPAaqplefAQFPFLLHGLQKTADFVEAIEGAR--AACTEAGQAgVHAYPSGSPFLFWEQYLGLRRC 963
Cdd:TIGR00917 980 --SAVDLQGYATIIQA------SSFRTYHTPLNTQVDFINAMRAAQefAAKVSRSSK-MEVYPYSVFYVFFEQYLTIWKT 1050
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 964 FLLAVCILLVCTFLVCALLL-LSPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASIGIGVEFTVHVALGFLT 1042
Cdd:TIGR00917 1051 AIINLSIALGAIFIVCLFLLqLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFST 1130
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....*....
gi 6679517 1043 S-HGSRNLRAASALEQTFAPVTDGAVST-LLGLLMLAGSNFDFIIRYFF 1089
Cdd:TIGR00917 1131 GkHFSRNHRAKEALGGMGSSVFSGITLTkLVGVVVLGFSRSEIFVVYYF 1179
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
374-1077 |
3.41e-39 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 157.52 E-value: 3.41e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 374 QIHAFSSTTLDDILRAFSEVSTTRVVGGYLLMLAYACVT-----MLRWDCAQSQGAVGLAGVLLVALAVASGLGLCALLG 448
Cdd:pfam02460 195 QFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVsvtlsSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMG 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 449 ITFNAATTqVLPFLALGIGVDDIFLLAHAFTKAPPDTPLPERMGECLRSTGTSVALTSVNNMVAFFMAALVPIPALRAFS 528
Cdd:pfam02460 275 FPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFC 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 529 LQAAIVVGCNFAAVMLVFPAILSLDLRRRHRQRLDVLCCFSSPcsaqviqmlPQELGDRavpvgiahltatvqafthcea 608
Cdd:pfam02460 354 AYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVWATSS---------PQRIDSE--------------------- 403
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 609 ssqhvvTILPPQAHLLSPASdplgselyspggstrdllsqeegtgpqaacrpllcahwtlAHFARYQFAPLLLQTRAKAL 688
Cdd:pfam02460 404 ------GSEPDKSHNIEQLK----------------------------------------SRFFLDIYCPFLLNPSVRVC 437
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 689 VLLFFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQ----LRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFS 764
Cdd:pfam02460 438 MLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLRekhfWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFE 517
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 765 SLKAVLPPPATQaprTWLHYYRSWLQGIQAAFDQDwasgritchsyrngsedgalayklliqtgnaqepldfsqlttrkl 844
Cdd:pfam02460 518 NTPYSLGPNSTL---FWLREYENFLSTLNMEEEED--------------------------------------------- 549
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 845 vdkeglIPPELFYMGLTVWvssdplgLAASqanFYPPppeWLHDKY--DTTGEnlripaaqpLEFAQFPFLLHGLQKTAD 922
Cdd:pfam02460 550 ------EEKEWSYGNLPSF-------LKAP---GNSH---WAGDLVwdDNTTM---------VTKFRFTLAGKGLSTWND 601
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 923 FVEAIEGARAACTEAGQAGVHAYPSGSPFLfwEQYLGLRRCFLLAVCILLVCTFLVCALLLLSPWTAGLIVLVLAMMTVE 1002
Cdd:pfam02460 602 RTRALQEWRSIADQYPEFNVTVFDEDAPFA--DQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIG 679
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6679517 1003 LFGIMGFLGIKLSAIPVVILVASIGIGVEFTVHVALGFLTSHGSR-NLRAASALEQTFAPVTDGAVSTLLGLLMLA 1077
Cdd:pfam02460 680 VFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTpAERVVDALEALGWPVFQGGLSTILGVLVLL 755
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
384-1085 |
1.46e-17 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 88.38 E-value: 1.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 384 DDILRAFSEVSTTRVVGGYLLMLAYACVTMLRWdcaqsqgAVGLAGVLLVALAVASGLGLCALLGITFNAATTqVLPFLA 463
Cdd:COG1033 210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL-------RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 464 LGIGVDD-IFLLAHAFTKAPPDTPLPERMGECLRSTGTSVALTSVNNMVAFFMAALVPIPALRAFSLQAAIVVGCNFAAV 542
Cdd:COG1033 282 LAIGIDYgIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 543 MLVFPAILS-LDLRRRHRQRLDVLCCFSSPCSAqviqmlpqeLGDRAVPVGIAHLTATVqafthceassqhVVTILppqa 621
Cdd:COG1033 362 LTLLPALLSlLPRPKPKTRRLKKPPELGRLLAK---------LARFVLRRPKVILVVAL------------VLAVV---- 416
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 622 hllspasdplgselyspggstrdllsqeegtgpqaacrpllcahwtlahfaryqfaplllqtrakalvllffgallglSL 701
Cdd:COG1033 417 ------------------------------------------------------------------------------SL 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 702 YGATLVQDGLALTDVVPRGTKehaflsaqlryfslyevalvtqggfdyahSQRALFDLHQRFSS---LKAVLPPPATQAP 778
Cdd:COG1033 419 YGISRLKVEYDFEDYLPEDSP-----------------------------IRQDLDFIEENFGGsdpLEVVVDTGEPDGL 469
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 779 RTwlHYYRSWLQGIQAAFDQDWASGRITchSYrngsedgALAYKLLIQTGNAQEPLDFsqlttrKLVDKEGLIPPELFYM 858
Cdd:COG1033 470 KD--PEVLKEIDRLQDYLESLPEVGKVL--SL-------ADLVKELNQALNEGDPKYY------ALPESRELLAQLLLLL 532
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 859 GLtvwvssdplglaasqanfypPPPEWLHDKYDTTGENLRIpaaqplefaQFPFLLHGLQKTADFVEAIEgaRAACTEAG 938
Cdd:COG1033 533 SS--------------------PPGDDLSRFVDEDYSAARV---------TVRLKDLDSEEIKALVEEVR--AFLAENFP 581
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 939 QAGVHAYPSGSPFLF--WEQYL--GLRRCFLLAvcILLVctFLVCALLLLSpWTAGLIVLVLAMMTVEL-FGIMGFLGIK 1013
Cdd:COG1033 582 PDGVEVTLTGSAVLFaaINESVieSQIRSLLLA--LLLI--FLLLLLAFRS-LRLGLISLIPNLLPILLtFGLMGLLGIP 656
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6679517 1014 LSAIPVVILVASIGIGVEFTVHVALGF---LTSHGSRNLRAASALEQTFAPVTDGAVSTLLGLLMLAGSNFDFII 1085
Cdd:COG1033 657 LNIATAVVASIALGIGVDYTIHFLSRYreeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLA 731
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
909-1088 |
1.13e-14 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 79.13 E-value: 1.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 909 QFPFLLHGLQKTADFVEAIEGARAACTEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLSPWT 988
Cdd:COG1033 165 VVTLDPDPLSSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRG 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 989 AGLIVLVLAMMTVELFGIMGFLGIKLS----AIPVVIlvasIGIGVEFTVHVALGF---LTSHGSRNLRAASALEQTFAP 1061
Cdd:COG1033 245 VLLPLLVVLLAVIWTLGLMGLLGIPLSpltiLVPPLL----LAIGIDYGIHLLNRYreeRRKGLDKREALREALRKLGPP 320
|
170 180
....*....|....*....|....*..
gi 6679517 1062 VTDGAVSTLLGLLMLAGSNFDfIIRYF 1088
Cdd:COG1033 321 VLLTSLTTAIGFLSLLFSDIP-PIRDF 346
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
425-561 |
1.70e-13 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 75.28 E-value: 1.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 425 VGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPfLALGIGVDDIFLLAHAFTKA-PPDTPLPERMGECLRSTGTSVA 503
Cdd:COG1033 631 LGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYTIHFLSRYREErRKGGDLEEAIRRALRTTGKAIL 709
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 6679517 504 LTSVNNMVAFFMAALVPIPALRAFSLQAAIVVGCNFAAVMLVFPAILSLdLRRRHRQR 561
Cdd:COG1033 710 FTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLL-LDPRIAKK 766
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
357-550 |
8.37e-07 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 53.46 E-value: 8.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 357 RRFVQLAQEALPANASQQIHAFSSTtlDDILRAFSEVSTTRVVGGYLLMLayacVTMLRWDCAqsqgAVGLAGVLLVALA 436
Cdd:TIGR03480 683 RRFVRAVRKVAPDATGAPVSILESG--DTVVGAFLQAFIYALVAITVLLL----LTLRRVRDV----LLVLAPLLLAGLL 752
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 437 VasgLGLCALLGITFNAATTQVLPFLaLGIGVDDIFLLAHAFTKAPPDTPLPErmgeclRSTGTSVALTSVNNMVAFFMA 516
Cdd:TIGR03480 753 T---VAAMVLLGIPFNFANIIALPLL-LGLGVDFGIYMVHRWRNGVDSGNLLQ------SSTARAVFFSALTTATAFGSL 822
|
170 180 190
....*....|....*....|....*....|....
gi 6679517 517 ALVPIPALRAFSLQAAIVVGCNFAAVMLVFPAIL 550
Cdd:TIGR03480 823 AVSSHPGTASMGILLSLGLGLTLLCTLIFLPALL 856
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
941-1087 |
1.77e-06 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 52.15 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 941 GVHAYPSGSPFLFWEQYLGLRRCF--LLAVCILLVCTFLvcaLLLLSPWTAGLIVLVLAMMTVEL-FGIMGFLGIKLSAI 1017
Cdd:TIGR00921 172 GKFLDVTGSPAINYDIEREFGKDMgtTMAISGILVVLVL---LLDFKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYAT 248
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6679517 1018 PVVILVASIGIGVEFTVHVALGFLTS-HGSRNLRAA--SALEQTFAPVTDGAVSTLLGLLMLAGSNFDFIIRY 1087
Cdd:TIGR00921 249 TLLAVPMLIGVGIDYGIQTLNRYEEErDIGRAKGEAivTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEF 321
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
423-563 |
5.81e-06 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 50.53 E-value: 5.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 423 GAVGLAGV--LLVALAVASGLGLCALLG--ITFNAATTQVLPFLALGIGVD-DIFLLA--HAFTKAPPDTPlpERMGECL 495
Cdd:COG2409 191 RSLVAALLplLTAGLAVGVALGLLALLAafTDVSSFAPNLLTMLGLGVGIDyALFLVSryREELRAGEDRE--EAVARAV 268
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6679517 496 RSTGTSV---ALTsVnnMVAFFMAALVPIPALRAFSLQAAIVVGCNFAAVMLVFPAILSL------DLRRRHRQRLD 563
Cdd:COG2409 269 ATAGRAVlfsGLT-V--AIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPALLALlgrrvfWPRRPRRRRAA 342
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
385-566 |
1.50e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 49.45 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 385 DILRAF--SEVSTTRVVGgyLLMLAYACVTMLRWdcaqsqgAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFL 462
Cdd:TIGR00921 186 DIEREFgkDMGTTMAISG--ILVVLVLLLDFKRW-------WRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPML 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 463 aLGIGVD-DIFLLAHAFTKAPPDTPLPERMGECLRSTGTSVALTSVNNmVAFFMAALVPI-PALRAFSLQAAIVVGCNFA 540
Cdd:TIGR00921 257 -IGVGIDyGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTT-SAGFAALALSEfPMVSEFGLGLVAGLITAYL 334
|
170 180
....*....|....*....|....*..
gi 6679517 541 AVMLVFPAIL-SLDLRRRHRQRLDVLC 566
Cdd:TIGR00921 335 LTLLVLPALLqSIDIGREKVKKEIIAI 361
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
425-552 |
4.31e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 47.91 E-value: 4.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 425 VGLAGVLLVALAVasgLGLCALLGITFNAaTTQVLPFLALGIGVDDIFLLAHAFTKAPPDTPLPERMGECLRSTGTSVaL 504
Cdd:TIGR00921 596 FPLIAIGSGILWA---IGLMGLRGIPSFL-AMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGI-L 670
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 6679517 505 TSVNNMVAFFMAALV-PIPALRAFSLQAAIVVGCNFAAVMLVFPAILSL 552
Cdd:TIGR00921 671 FSGLTTAGGFLSLLLsHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
941-1088 |
1.13e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 46.37 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 941 GVHAYPSGSPFLFWEQY----LGLRRcfllavcILLVCTFLVCALLLL---SPWTAglIVLVLAMMTVELF--GIMGFLG 1011
Cdd:TIGR00921 546 GVKVGVTGLPVAFAEMHelvnEGMRR-------MTIAGAILVLMILLAvfrNPIKA--VFPLIAIGSGILWaiGLMGLRG 616
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6679517 1012 IKLSAIPVVILVASIGIGVEFTVHVALGFLTSHGSRNLRAA--SALEQTFAPVTDGAVSTLLGLLMLAGSNFDfIIRYF 1088
Cdd:TIGR00921 617 IPSFLAMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAitHTMERTGPGILFSGLTTAGGFLSLLLSHFP-IMRNF 694
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
393-539 |
4.33e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 44.46 E-value: 4.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 393 VSTTRVVGGYLLMLAYACVTMLRWdcAQSQGAVGLAGVLLV-ALAVASGLGLCALLGITFNAATTQVLpFLALGIGVD-D 470
Cdd:COG4258 634 FGRYRNDALWLLLLALLLILLLLL--LRLRSLRRALRVLLPpLLAVLLTLAILGLLGIPLNLFHLIAL-LLVLGIGIDyA 710
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6679517 471 IFLLAHAFTKAPpdtplpermgecLRSTGTSVALTSVNNMVAFFMAALVPIPALRAFSLQAAIVVGCNF 539
Cdd:COG4258 711 LFFTEGLLDKGE------------LARTLLSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLAL 767
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
965-1079 |
1.03e-03 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 43.30 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 965 LLAVCILLVctFLVCALLLLSPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASIGIGVEFTVhvalgFLTSH 1044
Cdd:COG4258 644 LLLLALLLI--LLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYAL-----FFTEG 716
|
90 100 110
....*....|....*....|....*....|....*
gi 6679517 1045 gsrnLRAASALEQTFAPVTDGAVSTLLGLLMLAGS 1079
Cdd:COG4258 717 ----LLDKGELARTLLSILLAALTTLLGFGLLAFS 747
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
423-552 |
4.15e-03 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 40.74 E-value: 4.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679517 423 GAVGLAgvLLVALAVASGLGLCALLGITfnaatTQVLPF---LALGIGVD-DIFLLA--HAFTKAPPDTPlpERMGECLR 496
Cdd:pfam03176 174 LTVGLS--LGAAQGLVAILAHILGIGLS-----TFALNLlvvLLIAVGTDyALFLVSryREELRAGEDRE--EAVIRAVR 244
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6679517 497 STGTSV---ALTsvnnmVAFFMAALV--PIPALRAFSLQAAIVVGCNFAAVMLVFPAILSL 552
Cdd:pfam03176 245 GTGKVVtaaGLT-----VAIAMLALSfaRLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
|
|
| |
