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Conserved domains on  [gi|6680255|ref|NP_032298|]
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homeobox protein Hox-C9 [Mus musculus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11151457)

homeobox domain-containing protein similar to double homeobox protein that may act as a transcription factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hox9_act pfam04617
Hox9 activation region; This family constitutes the N termini of the paralogous homeobox ...
 1-179 3.41e-79

Hox9 activation region; This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.


:

Pssm-ID: 461369  Cd Length: 182  Bit Score: 236.52  E-value: 3.41e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680255      1 MSATGPISNYYVDSLISHDNEDLLASRFPaTGAHPAAARPSGLVPDCSDFPSCSFAPKPAVFSTSWAPVPSQSSV----V 76
Cdd:pfam04617   1 MSTSGTLSNYYVDSIISHESEDLYAPRFS-SGPHVQQARQPSGVADHADFPSCSFQPKSPVFSTSWSPVHPQSSAavpsV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680255     77 YHPYGPQPHLGA-DTRYMRTWLEPLSGAVSFPSFPAGGRHYALKPDAYPG-RRADCGPGDGRSYP---DYMYGSPGElrd 151
Cdd:pfam04617  80 YHPYVHQPHVPAsDGRYVRSWLEPISGSVSFPGLPSTGRHYGIKPEPLLGsKGGECTPLETHTRLlssDYARGSPAK--- 156

                         170       180
                  ....*....|....*....|....*...
gi 6680255    152 raPQTLPSPEADALAGSKHKEEKADLDP 179
Cdd:pfam04617 157 --PTSESSSSSEAKDESEGKEEKPELDP 182
Homeodomain pfam00046
Homeodomain;
193-241 1.43e-21

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 84.86  E-value: 1.43e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 6680255    193 RKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTERQVKIWFQ 241
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQ 49
 
Name Accession Description Interval E-value
Hox9_act pfam04617
Hox9 activation region; This family constitutes the N termini of the paralogous homeobox ...
 1-179 3.41e-79

Hox9 activation region; This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.


Pssm-ID: 461369  Cd Length: 182  Bit Score: 236.52  E-value: 3.41e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680255      1 MSATGPISNYYVDSLISHDNEDLLASRFPaTGAHPAAARPSGLVPDCSDFPSCSFAPKPAVFSTSWAPVPSQSSV----V 76
Cdd:pfam04617   1 MSTSGTLSNYYVDSIISHESEDLYAPRFS-SGPHVQQARQPSGVADHADFPSCSFQPKSPVFSTSWSPVHPQSSAavpsV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680255     77 YHPYGPQPHLGA-DTRYMRTWLEPLSGAVSFPSFPAGGRHYALKPDAYPG-RRADCGPGDGRSYP---DYMYGSPGElrd 151
Cdd:pfam04617  80 YHPYVHQPHVPAsDGRYVRSWLEPISGSVSFPGLPSTGRHYGIKPEPLLGsKGGECTPLETHTRLlssDYARGSPAK--- 156

                         170       180
                  ....*....|....*....|....*...
gi 6680255    152 raPQTLPSPEADALAGSKHKEEKADLDP 179
Cdd:pfam04617 157 --PTSESSSSSEAKDESEGKEEKPELDP 182
Homeodomain pfam00046
Homeodomain;
193-241 1.43e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 84.86  E-value: 1.43e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 6680255    193 RKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTERQVKIWFQ 241
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQ 49
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 192-241 1.18e-20

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 82.30  E-value: 1.18e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 6680255     192 TRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTERQVKIWFQ 241
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQ 50
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 193-241 8.70e-20

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 80.37  E-value: 8.70e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 6680255  193 RKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTERQVKIWFQ 241
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQ 49
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
154-241 6.69e-08

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 50.90  E-value: 6.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680255  154 PQTLPSPEADALAGSKHKEEKADLDPSNPvANWIHARSTRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTE 233
Cdd:COG5576  14 SQRMPQIRTIKTTKNKREVEAADSEMKLE-RKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPP 92


                ....*...
gi 6680255  234 RQVKIWFQ 241
Cdd:COG5576  93 KSVQIWFQ 100
 
Name Accession Description Interval E-value
Hox9_act pfam04617
Hox9 activation region; This family constitutes the N termini of the paralogous homeobox ...
 1-179 3.41e-79

Hox9 activation region; This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.


Pssm-ID: 461369  Cd Length: 182  Bit Score: 236.52  E-value: 3.41e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680255      1 MSATGPISNYYVDSLISHDNEDLLASRFPaTGAHPAAARPSGLVPDCSDFPSCSFAPKPAVFSTSWAPVPSQSSV----V 76
Cdd:pfam04617   1 MSTSGTLSNYYVDSIISHESEDLYAPRFS-SGPHVQQARQPSGVADHADFPSCSFQPKSPVFSTSWSPVHPQSSAavpsV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680255     77 YHPYGPQPHLGA-DTRYMRTWLEPLSGAVSFPSFPAGGRHYALKPDAYPG-RRADCGPGDGRSYP---DYMYGSPGElrd 151
Cdd:pfam04617  80 YHPYVHQPHVPAsDGRYVRSWLEPISGSVSFPGLPSTGRHYGIKPEPLLGsKGGECTPLETHTRLlssDYARGSPAK--- 156

                         170       180
                  ....*....|....*....|....*...
gi 6680255    152 raPQTLPSPEADALAGSKHKEEKADLDP 179
Cdd:pfam04617 157 --PTSESSSSSEAKDESEGKEEKPELDP 182
Homeodomain pfam00046
Homeodomain;
193-241 1.43e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 84.86  E-value: 1.43e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 6680255    193 RKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTERQVKIWFQ 241
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQ 49
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 192-241 1.18e-20

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 82.30  E-value: 1.18e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 6680255     192 TRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTERQVKIWFQ 241
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQ 50
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 193-241 8.70e-20

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 80.37  E-value: 8.70e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 6680255  193 RKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTERQVKIWFQ 241
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQ 49
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
154-241 6.69e-08

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 50.90  E-value: 6.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680255  154 PQTLPSPEADALAGSKHKEEKADLDPSNPvANWIHARSTRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTE 233
Cdd:COG5576  14 SQRMPQIRTIKTTKNKREVEAADSEMKLE-RKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPP 92


                ....*...
gi 6680255  234 RQVKIWFQ 241
Cdd:COG5576  93 KSVQIWFQ 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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