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Conserved domains on  [gi|45592928|ref|NP_032273|]
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phospholipid phosphatase 1 isoform 1 [Mus musculus]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 99-244 3.73e-71

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 215.96  E-value: 3.73e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928  99 IYKAVGAFLFGVSASQSLTDIAKYTIGSLRPHFLAICNPDWSKINCS---DGYIEDYICQGNEEKVKEGRLSFYSGHSSF 175
Cdd:cd03384   2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSldhQYIADCTCCTGDPDLIREARLSFPSGHASL 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45592928 176 SMYCMLFVALYLQARMKGDWARLLRPMLQFGLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILVA 244
Cdd:cd03384  82 SMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 99-244 3.73e-71

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 215.96  E-value: 3.73e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928  99 IYKAVGAFLFGVSASQSLTDIAKYTIGSLRPHFLAICNPDWSKINCS---DGYIEDYICQGNEEKVKEGRLSFYSGHSSF 175
Cdd:cd03384   2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSldhQYIADCTCCTGDPDLIREARLSFPSGHASL 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45592928 176 SMYCMLFVALYLQARMKGDWARLLRPMLQFGLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILVA 244
Cdd:cd03384  82 SMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
acidPPc smart00014
Acid phosphatase homologues;
107-243 1.43e-25

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 97.80  E-value: 1.43e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928    107 LFGVSASQSLTDIAKYTIGSLRPHFLAICnpdwskincsdgyieDYICQGNEEKVKEGRLSFYSGHSSFSMYCMLFVALY 186
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIG---------------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 45592928    187 LqarmkgdWARLLRPMLQFGLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILV 243
Cdd:smart00014  66 L-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PLN02250 PLN02250
lipid phosphate phosphatase
 29-277 2.17e-23

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 96.92  E-value: 2.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928   29 LGKVYPFQRgFFCTD--NSVKYPYHDSTIPSRILAILGLGLPIfsmsigESLSVYFnvlhsnsFVGNPyIATIYKAVGAF 106
Cdd:PLN02250  39 LNVIEPFHR-FVGKDmlTDLSYPLQDNTIPFWAVPLIAILLPF------AVILVYY-------FIRRD-VYDLHHAILGL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928  107 LFGVSASQSLTDIAKYTIGSLRPHFLAICNPDWSKIncSDGYIEDYICQGNEEKVKEGRLSFYSGHSSFSMYCMLFVALY 186
Cdd:PLN02250 104 LFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGV--FHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLY 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928  187 LQARM-----KGDWARLLRPMLQFGLIAFsiyVGLSRVSDYKHHWSDVTVGLIQGAAMAILVALyvsDFFKDTHsykERK 261
Cdd:PLN02250 182 LSGKIrvfdrRGHVAKLCIVFLPLLVAAL---VGVSRVDDYWHHWQDVFAGALIGLTVASFCYL---QFFPPPY---DID 252

                        250
                 ....*....|....*.
gi 45592928  262 EEDPHTTLHETASSRN 277
Cdd:PLN02250 253 GWGPHAYFQMLAESRN 268
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 105-247 7.14e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 82.85  E-value: 7.14e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928   105 AFLFGVSASQSLTDIAKYTIGSLRPHFLAICNPDWSkincsdgyiedyicqgNEEKVKEGRLSFYSGHSSFSMYCMLFVA 184
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP----------------APSTLPGLGYSFPSGHSATAFALALLLA 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45592928   185 LYLqarmkGDWARLLRPMLQFGLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILVALYV 247
Cdd:pfam01569  65 LLL-----RRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 102-247 9.46e-06

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 45.42  E-value: 9.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928 102 AVGAFLFGVSASQSLTDIAKYTIGSLRPHFLAICNPDwskINCSDGYiedyicqgneekvkegrlSFYSGHSSFSMYCML 181
Cdd:COG0671  74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELL---LGTAGGY------------------SFPSGHAAAAFALAL 132

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45592928 182 FVALYLQARmkgdWARLLrpmlqfgLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILVALYV 247
Cdd:COG0671 133 VLALLLPRR----WLAAL-------LLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 99-244 3.73e-71

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 215.96  E-value: 3.73e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928  99 IYKAVGAFLFGVSASQSLTDIAKYTIGSLRPHFLAICNPDWSKINCS---DGYIEDYICQGNEEKVKEGRLSFYSGHSSF 175
Cdd:cd03384   2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSldhQYIADCTCCTGDPDLIREARLSFPSGHASL 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45592928 176 SMYCMLFVALYLQARMKGDWARLLRPMLQFGLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILVA 244
Cdd:cd03384  82 SMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 45-243 6.36e-36

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 127.34  E-value: 6.36e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928  45 SVKYPYHDS-TIPSRILAILGLGLP---IFSMSIGESLSVYFnvlhsnsfvgnpyiatIYKAVGAFLFGVSASQSLTDIA 120
Cdd:cd03390   2 SISYPFAESeTVPTWLLVIISVGIPllvIILISLFFRRSLWD----------------LHTSLLGLLLSVSLNGVITNVL 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928 121 KYTIGSLRPHFLAICNPDwsKINCSDGYIEDYIC-QGNEEKVKEGRLSFYSGHSSFSMYCMLFVALYLQARMK--GDWAR 197
Cdd:cd03390  66 KNYAGRPRPDFLARCFPD--GGTPSDTLVGIDICcTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHifDPRGS 143

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 45592928 198 LLRPMLQFGLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILV 243
Cdd:cd03390 144 SWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLS 189
acidPPc smart00014
Acid phosphatase homologues;
107-243 1.43e-25

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 97.80  E-value: 1.43e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928    107 LFGVSASQSLTDIAKYTIGSLRPHFLAICnpdwskincsdgyieDYICQGNEEKVKEGRLSFYSGHSSFSMYCMLFVALY 186
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIG---------------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 45592928    187 LqarmkgdWARLLRPMLQFGLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILV 243
Cdd:smart00014  66 L-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PLN02250 PLN02250
lipid phosphate phosphatase
 29-277 2.17e-23

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 96.92  E-value: 2.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928   29 LGKVYPFQRgFFCTD--NSVKYPYHDSTIPSRILAILGLGLPIfsmsigESLSVYFnvlhsnsFVGNPyIATIYKAVGAF 106
Cdd:PLN02250  39 LNVIEPFHR-FVGKDmlTDLSYPLQDNTIPFWAVPLIAILLPF------AVILVYY-------FIRRD-VYDLHHAILGL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928  107 LFGVSASQSLTDIAKYTIGSLRPHFLAICNPDWSKIncSDGYIEDYICQGNEEKVKEGRLSFYSGHSSFSMYCMLFVALY 186
Cdd:PLN02250 104 LFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGV--FHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLY 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928  187 LQARM-----KGDWARLLRPMLQFGLIAFsiyVGLSRVSDYKHHWSDVTVGLIQGAAMAILVALyvsDFFKDTHsykERK 261
Cdd:PLN02250 182 LSGKIrvfdrRGHVAKLCIVFLPLLVAAL---VGVSRVDDYWHHWQDVFAGALIGLTVASFCYL---QFFPPPY---DID 252

                        250
                 ....*....|....*.
gi 45592928  262 EEDPHTTLHETASSRN 277
Cdd:PLN02250 253 GWGPHAYFQMLAESRN 268
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 100-243 6.77e-23

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 90.98  E-value: 6.77e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928 100 YKAVGAFLFGVSASQSLTDIAKYTIGSLRPHFLAICNPDwskincsdgyiedyicqGNEEKVKEGRLSFYSGHSSFSMYC 179
Cdd:cd01610   2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPD-----------------GDPLLLTEGGYSFPSGHAAFAFAL 64

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45592928 180 MLFVALYLqarmkgdWARLLRPMLQFGLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILV 243
Cdd:cd01610  65 ALFLALLL-------PRRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLV 121
PLN02715 PLN02715
lipid phosphate phosphatase
 14-240 6.49e-21

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 90.50  E-value: 6.49e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928   14 VICVLLAAMPMTILKLGKVYPFQRGFFCTDnsVKYPYHDSTIPSRILAILGLGLPIfsmsigeslsvyfnVLHSNSFVGN 93
Cdd:PLN02715  52 IILVILIAIEIGLNLISPFYRYVGKDMMTD--LKYPFKDNTVPIWSVPVYAVLLPI--------------ILFVCFYLKR 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928   94 PYIATIYKAVGAFLFGVSASQSLTDIAKYTIGSLRPHFLAICNPDWSKINCSDGYIedyICQGNEEKVKEGRLSFYSGHS 173
Cdd:PLN02715 116 RCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGV---ICHGKAAEVKEGHKSFPSGHT 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45592928  174 SFSMYCMLFVALYLQARMK-----GDWARLLrpMLQFGLIAfSIYVGLSRVSDYKHHWSDVTVGLIQGAAMA 240
Cdd:PLN02715 193 SWSFAGLTFLSLYLSGKIKafngeGHVAKLC--LVIFPLLA-ACLVGISRVDDYWHHWQDVFAGALIGILVA 261
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 14-236 1.44e-20

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 89.70  E-value: 1.44e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928   14 VICVLLAAMPMTILKLGKVYPFQRGFFCTDnsVKYPYHDSTIPSRILAILGLGLPIFSMsigesLSVYFNvlhsnsfvgN 93
Cdd:PLN02731  46 IILVLLVILECVLLIIHPFYRFVGKDMMTD--LSYPLKSNTVPIWSVPVYAMLLPLVIF-----IFIYFR---------R 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928   94 PYIATIYKAVGAFLFGVSASQSLTDIAKYTIGSLRPHFLAICNPDWSKINCSDGyieDYICQGNEEKVKEGRLSFYSGHS 173
Cdd:PLN02731 110 RDVYDLHHAVLGLLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALYDSLG---DVICHGDKSVIREGHKSFPSGHT 186

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45592928  174 SFSMYCMLFVALYLQARM-----KGDWARLLRPMLQfglIAFSIYVGLSRVSDYKHHWSDVTVGLIQG 236
Cdd:PLN02731 187 SWSFSGLGFLSLYLSGKIqafdgKGHVAKLCIVILP---LLFAALVGISRVDDYWHHWQDVFAGGLLG 251
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 105-247 7.14e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 82.85  E-value: 7.14e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928   105 AFLFGVSASQSLTDIAKYTIGSLRPHFLAICNPDWSkincsdgyiedyicqgNEEKVKEGRLSFYSGHSSFSMYCMLFVA 184
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP----------------APSTLPGLGYSFPSGHSATAFALALLLA 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45592928   185 LYLqarmkGDWARLLRPMLQFGLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILVALYV 247
Cdd:pfam01569  65 LLL-----RRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 104-247 3.69e-11

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 58.88  E-value: 3.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928 104 GAFLFGVSASQSLTDIAKYTIGSLRPhflaicnpdwskincsDGYIEDYicqgneekvkegrLSFYSGHSS--FSmycml 181
Cdd:cd03394   6 LILAEAAALTAAVTEGLKFAVGRARP----------------DGSNNGY-------------RSFPSGHTAsaFA----- 51

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45592928 182 fVALYLQARMKGDWArllrpmlQFGLIAFSIYVGLSRVSDYKHHWSDVTVgliqGAAMAILVALYV 247
Cdd:cd03394  52 -AATFLQYRYGWRWY-------GIPAYALASLVGASRVVANRHWLSDVLA----GAAIGILVGYLV 105
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 102-247 9.46e-06

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 45.42  E-value: 9.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928 102 AVGAFLFGVSASQSLTDIAKYTIGSLRPHFLAICNPDwskINCSDGYiedyicqgneekvkegrlSFYSGHSSFSMYCML 181
Cdd:COG0671  74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELL---LGTAGGY------------------SFPSGHAAAAFALAL 132

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45592928 182 FVALYLQARmkgdWARLLrpmlqfgLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILVALYV 247
Cdd:COG0671 133 VLALLLPRR----WLAAL-------LLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 170-242 4.03e-05

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 43.03  E-value: 4.03e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45592928 170 SGHSSFSMYCMLFVALYLQARMKGDWARLLRPMLQFGLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAIL 242
Cdd:cd03382  85 SSHSQFMGFFAVYLLLFIYLRLGRLNSLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGIL 157
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 103-245 2.74e-04

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 40.71  E-value: 2.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928 103 VGAFLFGVS-ASQSLTDIAKYTIGSLRPHFLAICNPDWSKINCSDGYiedyicqgneekvkegrlSFYSGHSSFSMYCML 181
Cdd:cd03395  58 LLLVLLAVGfADQLASGFLKPLVARLRPCNALDGVRLVVLGDQGGSY------------------SFASSHAANSFALAL 119

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45592928 182 FVALYLqarmkgdWARLLRPMLqfglIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILVAL 245
Cdd:cd03395 120 FIWLFF-------RRGLFSPVL----LLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYL 172
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 92-247 1.26e-03

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 38.84  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928  92 GNPYIATIYKA--VGAFLFG-VSASQSLTDIAKYTIGSLRPHFlaicnpdwskincsdgYIEDYICQGNEEKVKEGRLSF 168
Cdd:cd03389  57 SAPSRARFPKAawAGLFLFAtVALSGILVNLLKFIIGRARPKL----------------LFDDGLYGFDPFHADYAFTSF 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45592928 169 YSGHSS--FSMycmlFVALYLqarmkgdwarlLRPMLQFGLIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILVALY 246
Cdd:cd03389 121 PSGHSAtaGAA----AAALAL-----------LFPRYRWAFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQR 185


                .
gi 45592928 247 V 247
Cdd:cd03389 186 F 186
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 167-243 9.11e-03

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 36.14  E-value: 9.11e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45592928 167 SFYSGHSSFSMYCMLFVALYLqarmkgDWARLLRPMLqfglIAFSIYVGLSRVSDYKHHWSDVTVGLIQGAAMAILV 243
Cdd:cd03391  92 SFPSGHASRAAFVARFLLNHL------VLAVPLRVLL----VLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALLV 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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