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Conserved domains on  [gi|36031132|ref|NP_031530|]
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sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [Mus musculus]

Protein Classification

calcium-transporting ATPase( domain architecture ID 11550595)

calcium-transporting ATPase such as sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle, which re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction.

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
5-989 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


:

Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 2029.91  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   5 HSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEGEET 84
Cdd:cd02083   1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  85 VTAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADrKSVQRIKARDIVPGDIVEVAVGDKVPADIR 164
Cdd:cd02083  81 VTAFVEPFVILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNG-KGVQRIRARELVPGDIVEVAVGDKVPADIR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 165 ILSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQ 244
Cdd:cd02083 160 IIEIKSTTLRVDQSILTGESVSVIKHTDVVPDPRAVNQDKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 245 DKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 324
Cdd:cd02083 240 EKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 325 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDgDVCSLNEFSITGSTYAPEGEVLKNDKPVRA 404
Cdd:cd02083 320 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVE-DDSSLNEFEVTGSTYAPEGEVFKNGKKVKA 398
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 405 GQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRSLSKVERANACNSVIRQLMKKEFT 484
Cdd:cd02083 399 GQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVEKMNVFNTDKSGLSKRERANACNDVIEQLWKKEFT 478
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 485 LEFSRDRKSMSVYCSPAKSSRaavGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVkEKIMSVIKEWGTGRDTLRCLAL 564
Cdd:cd02083 479 LEFSRDRKSMSVYCSPTKASG---GNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAA-IKILILKKVWGYGTDTLRCLAL 554
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 565 ATRDTPPKREEMVLDDSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSE 644
Cdd:cd02083 555 ATKDTPPKPEDMDLEDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGE 634
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 645 NEEVTDRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGT 724
Cdd:cd02083 635 DEDTTGKSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGT 714
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 725 AVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPA 804
Cdd:cd02083 715 AVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPA 794
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 805 TALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFLYAEDGPHVSYHQLTHFMQCTEHNPEFD 884
Cdd:cd02083 795 TALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFAWWFMYYEEGPQVSFYQLTHFMQCSSWEPNFE 874
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 885 GLDCEVFEAPEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDF 964
Cdd:cd02083 875 GVDCEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQITPLSF 954
                       970       980
                ....*....|....*....|....*
gi 36031132 965 TQWLMVLKISLPVIGLDELLKFIAR 989
Cdd:cd02083 955 AEWIAVIKISLPVILLDELLKFIAR 979
 
Name Accession Description Interval E-value
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
5-989 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 2029.91  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   5 HSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEGEET 84
Cdd:cd02083   1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  85 VTAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADrKSVQRIKARDIVPGDIVEVAVGDKVPADIR 164
Cdd:cd02083  81 VTAFVEPFVILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNG-KGVQRIRARELVPGDIVEVAVGDKVPADIR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 165 ILSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQ 244
Cdd:cd02083 160 IIEIKSTTLRVDQSILTGESVSVIKHTDVVPDPRAVNQDKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 245 DKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 324
Cdd:cd02083 240 EKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 325 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDgDVCSLNEFSITGSTYAPEGEVLKNDKPVRA 404
Cdd:cd02083 320 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVE-DDSSLNEFEVTGSTYAPEGEVFKNGKKVKA 398
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 405 GQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRSLSKVERANACNSVIRQLMKKEFT 484
Cdd:cd02083 399 GQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVEKMNVFNTDKSGLSKRERANACNDVIEQLWKKEFT 478
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 485 LEFSRDRKSMSVYCSPAKSSRaavGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVkEKIMSVIKEWGTGRDTLRCLAL 564
Cdd:cd02083 479 LEFSRDRKSMSVYCSPTKASG---GNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAA-IKILILKKVWGYGTDTLRCLAL 554
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 565 ATRDTPPKREEMVLDDSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSE 644
Cdd:cd02083 555 ATKDTPPKPEDMDLEDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGE 634
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 645 NEEVTDRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGT 724
Cdd:cd02083 635 DEDTTGKSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGT 714
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 725 AVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPA 804
Cdd:cd02083 715 AVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPA 794
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 805 TALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFLYAEDGPHVSYHQLTHFMQCTEHNPEFD 884
Cdd:cd02083 795 TALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFAWWFMYYEEGPQVSFYQLTHFMQCSSWEPNFE 874
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 885 GLDCEVFEAPEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDF 964
Cdd:cd02083 875 GVDCEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQITPLSF 954
                       970       980
                ....*....|....*....|....*
gi 36031132 965 TQWLMVLKISLPVIGLDELLKFIAR 989
Cdd:cd02083 955 AEWIAVIKISLPVILLDELLKFIAR 979
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
53-989 0e+00

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 1648.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    53 VVEQFEDLLVRILLLAACISFVLAWFEEGEETVTAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRA 132
Cdd:TIGR01116   1 VLEQFEDLLVRILLLAACVSFVLAWFEEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKAIEALKEYESEHAKVLRD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   133 DRKSVqrIKARDIVPGDIVEVAVGDKVPADIRILSIKstTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGT 212
Cdd:TIGR01116  81 GRWSV--IKAKDLVPGDIVELAVGDKVPADIRVLSLK--TLRVDQSILTGESVSVNKHTESVPDERAVNQDKKNMLFSGT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   213 NIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGA 292
Cdd:TIGR01116 157 LVVAGKARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDEFGELLSKVIGLICILVWVINIGHFNDPALGGGWIQGA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   293 IYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKV 372
Cdd:TIGR01116 237 IYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVALDPS 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   373 DgdvCSLNEFSITGSTYAPEGEVLKNDKPVRAGQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKM 452
Cdd:TIGR01116 317 S---SSLNEFCVTGTTYAPEGGVIKDDGPVAGGQDAGLEELATIAALCNDSSLDFNERKGVYEKVGEATEAALKVLVEKM 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   453 NVFNTEVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAkssraaVGNKMFVKGAPEGVIDRCNYVRVGT 532
Cdd:TIGR01116 394 GLPATKNGVSSKRRPALGCNSVWNDKFKKLATLEFSRDRKSMSVLCKPS------TGNKLFVKGAPEGVLERCTHILNGD 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   533 TR-VPLTGPVKEKIMSVIKEWGTgRDTLRCLALATRDTPPKREEMVLDDSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSI 611
Cdd:TIGR01116 468 GRaVPLTDKMKNTILSVIKEMGT-TKALRCLALAFKDIPDPREEDLLSDPANFEAIESDLTFIGVVGMLDPPRPEVADAI 546
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   612 QLCRDAGIRVIMITGDNKGTAIAICRRIGIFSENEEVTDRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYL 691
Cdd:TIGR01116 547 EKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDVTFKSFTGREFDEMGPAKQRAACRSAVLFSRVEPSHKSELVELL 626
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   692 QSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGE 771
Cdd:TIGR01116 627 QEQGEIVAMTGDGVNDAPALKKADIGIAMGSGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGE 706
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   772 VVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGaatvga 851
Cdd:TIGR01116 707 VVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITGWLFFRYLVVGVYVG------ 780
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   852 aawwflYAEDGPHVSYHQLTHFMQCTEHN----PEFDGLDCEVFEAPEPM-TMALSVLVTIEMCNALNSLSENQSLLRMP 926
Cdd:TIGR01116 781 ------LATVGGFVWWYLLTHFTGCDEDSfttcPDFEDPDCYVFEGKQPArTISLSVLVVIEMFNALNALSEDQSLLRMP 854
                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 36031132   927 PWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDFTQWLMVLKISLPVIGLDELLKFIAR 989
Cdd:TIGR01116 855 PWVNKWLIGAICLSMALHFLILYVPFLSRIFGVTPLSLTDWLMVLKLSLPVILVDEVLKFFSR 917
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
1-991 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 929.52  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   1 MEAAHSKSTEECLSYFGVSETtGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLawfee 80
Cdd:COG0474   5 LKDWHALSAEEVLAELGTSEE-GLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL----- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  81 GEetvtaFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRaDRKsVQRIKARDIVPGDIVEVAVGDKVP 160
Cdd:COG0474  79 GD-----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLR-DGK-WVEIPAEELVPGDIVLLEAGDRVP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 161 ADIRILSIKSttLRVDQSILTGESVSVIKHTDPVPDPRAVnQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMA 240
Cdd:COG0474 152 ADLRLLEAKD--LQVDESALTGESVPVEKSADPLPEDAPL-GDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQ 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 241 ATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIghfndpVHGGSWFR----------GAIyyfkiavalavaaiPEG 310
Cdd:COG0474 229 EAEEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGL------LRGGPLLEallfavalavAAI--------------PEG 288
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 311 LPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKvdgdvcslnEFSITGSTYA 390
Cdd:COG0474 289 LPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGG---------TYEVTGEFDP 359
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 391 PEGEVLKndkpvragqydglvelatICALCNDSSLDFNETkgvyekVGEATETALTTLVEKMNVFNTEvrslskverana 470
Cdd:COG0474 360 ALEELLR------------------AAALCSDAQLEEETG------LGDPTEGALLVAAAKAGLDVEE------------ 403
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 471 cnsvIRQLMKKEFTLEFSRDRKSMSVYCSpakssRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIK 550
Cdd:COG0474 404 ----LRKEYPRVDEIPFDSERKRMSTVHE-----DPDGKRLLIVKGAPEVVLALCTRVLTGGGVVPLTEEDRAEILEAVE 474
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 551 EWGtgRDTLRCLALATRDTPPKREEMVLDDsakfmeyEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKG 630
Cdd:COG0474 475 ELA--AQGLRVLAVAYKELPADPELDSEDD-------ESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPA 545
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 631 TAIAICRRIGIFSENeevtDRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPA 710
Cdd:COG0474 546 TARAIARQLGLGDDG----DRVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPA 621
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 711 LKKAEIGIAMG-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIP 789
Cdd:COG0474 622 LKAADIGIAMGiTGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTP 701
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 790 VQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYvgaatvGAAAWWFLYAedgphVSYHQ 869
Cdd:COG0474 702 IQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLL------IAIFTLLTFA-----LALAR 770
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 870 lthfmqctehnpefdGLDCEVFeapepMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILY 949
Cdd:COG0474 771 ---------------GASLALA-----RTMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIY 830
                       970       980       990      1000
                ....*....|....*....|....*....|....*....|..
gi 36031132 950 VDPLPMIFKLRALDFTQWLMVLKISLPVIGLDELLKFIARNY 991
Cdd:COG0474 831 VPPLQALFGTVPLPLSDWLLILGLALLYLLLVELVKLLRRRF 872
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
9-822 3.04e-93

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 316.24  E-value: 3.04e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    9 TEECLSYFGvSETTGLTPDQVKRHLEKYGPNELPAEEG----KSLWELVVEQFEDLLVrilLLAAcISFVlawfeegEET 84
Cdd:PRK10517  54 EEELWKTFD-THPEGLNEAEVESAREQHGENELPAQKPlpwwVHLWVCYRNPFNILLT---ILGA-ISYA-------TED 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   85 VTAFVepfVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRAD----RKSVQRIKARDIVPGDIVEVAVGDKVP 160
Cdd:PRK10517 122 LFAAG---VIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRVIndkgENGWLEIPIDQLVPGDIIKLAAGDMIP 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  161 ADIRILSIKSttLRVDQSILTGESVSVIKhtdpVPDPRAVNQ----DKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIR 236
Cdd:PRK10517 199 ADLRILQARD--LFVAQASLTGESLPVEK----FATTRQPEHsnplECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLA 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  237 DQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINiGHFNdpvhgGSWFRGAIYyfkiAVALAVAAIPEGLPAVIT 316
Cdd:PRK10517 273 GRVSEQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLIN-GYTK-----GDWWEAALF----ALSVAVGLTPEMLPMIVT 342
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  317 TCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNqmsvcKMFIIDKVD--GDVCS-------LNEFSITGs 387
Cdd:PRK10517 343 STLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQD-----KIVLENHTDisGKTSErvlhsawLNSHYQTG- 416
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  388 tyapegevLKNdkpvragqydgLVELAticalcndssldfnetkgVYEKVGEATETALTTLVEKMNvfntevrslskver 467
Cdd:PRK10517 417 --------LKN-----------LLDTA------------------VLEGVDEESARSLASRWQKID-------------- 445
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  468 anacnsvirqlmkkEFTLEFSRDRKSMSVycspakSSRAAVgNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMS 547
Cdd:PRK10517 446 --------------EIPFDFERRRMSVVV------AENTEH-HQLICKGALEEILNVCSQVRHNGEIVPLDDIMLRRIKR 504
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  548 VIKEWGtgRDTLRCLALATRDTPPKREEMVLDDsakfmeyEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGD 627
Cdd:PRK10517 505 VTDTLN--RQGLRVVAVATKYLPAREGDYQRAD-------ESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGD 575
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  628 NKGTAIAICRRIGIfseneeVTDRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVND 707
Cdd:PRK10517 576 SELVAAKVCHEVGL------DAGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTLLKREGHVVGFMGDGIND 649
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  708 APALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAAL--GLPe 785
Cdd:PRK10517 650 APALRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNFGNVFSVLVASAFlpFLP- 728
                        810       820       830
                 ....*....|....*....|....*....|....*..
gi 36031132  786 aLIPVQLLWVNLVTDgLPATALGFNPPDLDIMDRPPR 822
Cdd:PRK10517 729 -MLPLHLLIQNLLYD-VSQVAIPFDNVDDEQIQKPQR 763
E1-E2_ATPase pfam00122
E1-E2 ATPase;
121-329 7.51e-46

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 162.74  E-value: 7.51e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   121 EYEPEMGKVYRADrkSVQRIKARDIVPGDIVEVAVGDKVPADIRILSiksTTLRVDQSILTGESVSVIKHtdpvpdprav 200
Cdd:pfam00122   1 SLLPPTATVLRDG--TEEEVPADELVPGDIVLLKPGERVPADGRIVE---GSASVDESLLTGESLPVEKK---------- 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   201 nqdKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIghfn 280
Cdd:pfam00122  66 ---KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWL---- 138
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 36031132   281 dpvhggSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKK 329
Cdd:pfam00122 139 ------FVGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
5-75 6.80e-19

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 81.86  E-value: 6.80e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 36031132      5 HSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVL 75
Cdd:smart00831   5 HALSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
 
Name Accession Description Interval E-value
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
5-989 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 2029.91  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   5 HSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEGEET 84
Cdd:cd02083   1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  85 VTAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADrKSVQRIKARDIVPGDIVEVAVGDKVPADIR 164
Cdd:cd02083  81 VTAFVEPFVILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNG-KGVQRIRARELVPGDIVEVAVGDKVPADIR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 165 ILSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQ 244
Cdd:cd02083 160 IIEIKSTTLRVDQSILTGESVSVIKHTDVVPDPRAVNQDKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 245 DKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 324
Cdd:cd02083 240 EKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 325 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDgDVCSLNEFSITGSTYAPEGEVLKNDKPVRA 404
Cdd:cd02083 320 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVE-DDSSLNEFEVTGSTYAPEGEVFKNGKKVKA 398
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 405 GQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRSLSKVERANACNSVIRQLMKKEFT 484
Cdd:cd02083 399 GQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVEKMNVFNTDKSGLSKRERANACNDVIEQLWKKEFT 478
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 485 LEFSRDRKSMSVYCSPAKSSRaavGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVkEKIMSVIKEWGTGRDTLRCLAL 564
Cdd:cd02083 479 LEFSRDRKSMSVYCSPTKASG---GNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAA-IKILILKKVWGYGTDTLRCLAL 554
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 565 ATRDTPPKREEMVLDDSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSE 644
Cdd:cd02083 555 ATKDTPPKPEDMDLEDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGE 634
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 645 NEEVTDRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGT 724
Cdd:cd02083 635 DEDTTGKSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGT 714
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 725 AVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPA 804
Cdd:cd02083 715 AVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPA 794
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 805 TALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFLYAEDGPHVSYHQLTHFMQCTEHNPEFD 884
Cdd:cd02083 795 TALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFAWWFMYYEEGPQVSFYQLTHFMQCSSWEPNFE 874
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 885 GLDCEVFEAPEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDF 964
Cdd:cd02083 875 GVDCEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQITPLSF 954
                       970       980
                ....*....|....*....|....*
gi 36031132 965 TQWLMVLKISLPVIGLDELLKFIAR 989
Cdd:cd02083 955 AEWIAVIKISLPVILLDELLKFIAR 979
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
53-989 0e+00

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 1648.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    53 VVEQFEDLLVRILLLAACISFVLAWFEEGEETVTAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRA 132
Cdd:TIGR01116   1 VLEQFEDLLVRILLLAACVSFVLAWFEEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKAIEALKEYESEHAKVLRD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   133 DRKSVqrIKARDIVPGDIVEVAVGDKVPADIRILSIKstTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGT 212
Cdd:TIGR01116  81 GRWSV--IKAKDLVPGDIVELAVGDKVPADIRVLSLK--TLRVDQSILTGESVSVNKHTESVPDERAVNQDKKNMLFSGT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   213 NIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGA 292
Cdd:TIGR01116 157 LVVAGKARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDEFGELLSKVIGLICILVWVINIGHFNDPALGGGWIQGA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   293 IYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKV 372
Cdd:TIGR01116 237 IYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVALDPS 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   373 DgdvCSLNEFSITGSTYAPEGEVLKNDKPVRAGQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKM 452
Cdd:TIGR01116 317 S---SSLNEFCVTGTTYAPEGGVIKDDGPVAGGQDAGLEELATIAALCNDSSLDFNERKGVYEKVGEATEAALKVLVEKM 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   453 NVFNTEVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAkssraaVGNKMFVKGAPEGVIDRCNYVRVGT 532
Cdd:TIGR01116 394 GLPATKNGVSSKRRPALGCNSVWNDKFKKLATLEFSRDRKSMSVLCKPS------TGNKLFVKGAPEGVLERCTHILNGD 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   533 TR-VPLTGPVKEKIMSVIKEWGTgRDTLRCLALATRDTPPKREEMVLDDSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSI 611
Cdd:TIGR01116 468 GRaVPLTDKMKNTILSVIKEMGT-TKALRCLALAFKDIPDPREEDLLSDPANFEAIESDLTFIGVVGMLDPPRPEVADAI 546
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   612 QLCRDAGIRVIMITGDNKGTAIAICRRIGIFSENEEVTDRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYL 691
Cdd:TIGR01116 547 EKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDVTFKSFTGREFDEMGPAKQRAACRSAVLFSRVEPSHKSELVELL 626
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   692 QSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGE 771
Cdd:TIGR01116 627 QEQGEIVAMTGDGVNDAPALKKADIGIAMGSGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGE 706
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   772 VVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGaatvga 851
Cdd:TIGR01116 707 VVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITGWLFFRYLVVGVYVG------ 780
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   852 aawwflYAEDGPHVSYHQLTHFMQCTEHN----PEFDGLDCEVFEAPEPM-TMALSVLVTIEMCNALNSLSENQSLLRMP 926
Cdd:TIGR01116 781 ------LATVGGFVWWYLLTHFTGCDEDSfttcPDFEDPDCYVFEGKQPArTISLSVLVVIEMFNALNALSEDQSLLRMP 854
                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 36031132   927 PWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDFTQWLMVLKISLPVIGLDELLKFIAR 989
Cdd:TIGR01116 855 PWVNKWLIGAICLSMALHFLILYVPFLSRIFGVTPLSLTDWLMVLKLSLPVILVDEVLKFFSR 917
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
1-991 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 929.52  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   1 MEAAHSKSTEECLSYFGVSETtGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLawfee 80
Cdd:COG0474   5 LKDWHALSAEEVLAELGTSEE-GLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL----- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  81 GEetvtaFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRaDRKsVQRIKARDIVPGDIVEVAVGDKVP 160
Cdd:COG0474  79 GD-----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLR-DGK-WVEIPAEELVPGDIVLLEAGDRVP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 161 ADIRILSIKSttLRVDQSILTGESVSVIKHTDPVPDPRAVnQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMA 240
Cdd:COG0474 152 ADLRLLEAKD--LQVDESALTGESVPVEKSADPLPEDAPL-GDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQ 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 241 ATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIghfndpVHGGSWFR----------GAIyyfkiavalavaaiPEG 310
Cdd:COG0474 229 EAEEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGL------LRGGPLLEallfavalavAAI--------------PEG 288
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 311 LPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKvdgdvcslnEFSITGSTYA 390
Cdd:COG0474 289 LPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGG---------TYEVTGEFDP 359
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 391 PEGEVLKndkpvragqydglvelatICALCNDSSLDFNETkgvyekVGEATETALTTLVEKMNVFNTEvrslskverana 470
Cdd:COG0474 360 ALEELLR------------------AAALCSDAQLEEETG------LGDPTEGALLVAAAKAGLDVEE------------ 403
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 471 cnsvIRQLMKKEFTLEFSRDRKSMSVYCSpakssRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIK 550
Cdd:COG0474 404 ----LRKEYPRVDEIPFDSERKRMSTVHE-----DPDGKRLLIVKGAPEVVLALCTRVLTGGGVVPLTEEDRAEILEAVE 474
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 551 EWGtgRDTLRCLALATRDTPPKREEMVLDDsakfmeyEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKG 630
Cdd:COG0474 475 ELA--AQGLRVLAVAYKELPADPELDSEDD-------ESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPA 545
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 631 TAIAICRRIGIFSENeevtDRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPA 710
Cdd:COG0474 546 TARAIARQLGLGDDG----DRVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPA 621
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 711 LKKAEIGIAMG-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIP 789
Cdd:COG0474 622 LKAADIGIAMGiTGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTP 701
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 790 VQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYvgaatvGAAAWWFLYAedgphVSYHQ 869
Cdd:COG0474 702 IQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLL------IAIFTLLTFA-----LALAR 770
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 870 lthfmqctehnpefdGLDCEVFeapepMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILY 949
Cdd:COG0474 771 ---------------GASLALA-----RTMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIY 830
                       970       980       990      1000
                ....*....|....*....|....*....|....*....|..
gi 36031132 950 VDPLPMIFKLRALDFTQWLMVLKISLPVIGLDELLKFIARNY 991
Cdd:COG0474 831 VPPLQALFGTVPLPLSDWLLILGLALLYLLLVELVKLLRRRF 872
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
23-985 0e+00

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 733.30  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  23 GLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLawfeeGEetvtaFVEPFVILLILIANA 102
Cdd:cd02080   1 GLTSEEAAERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFL-----GH-----WVDAIVIFGVVLINA 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 103 IVGVWQERNAENAIEALKEYEPEMGKVYRADRKsvQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSttLRVDQSILTG 182
Cdd:cd02080  71 IIGYIQEGKAEKALAAIKNMLSPEATVLRDGKK--LTIDAEELVPGDIVLLEAGDKVPADLRLIEARN--LQIDESALTG 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 183 ESVSVIKHTDPVPdPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSK 262
Cdd:cd02080 147 ESVPVEKQEGPLE-EDTPLGDRKNMAYSGTLVTAGSATGVVVATGADTEIGRINQLLAEVEQLATPLTRQIAKFSKALLI 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 263 VIslICVAVWLINIGHFndpVHGGSW---FRGAIyyfkiavALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSV 339
Cdd:cd02080 226 VI--LVLAALTFVFGLL---RGDYSLvelFMAVV-------ALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAV 293
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 340 ETLGCTSVICSDKTGTLTTNQMSVCKMFiidkvdgdvcslnefsitgstyapegevlkndkpvragqydglvelaticAL 419
Cdd:cd02080 294 ETLGSVTVICSDKTGTLTRNEMTVQAIV--------------------------------------------------TL 323
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 420 CNDSSLDFNEtkGVYEKVGEATETALTTLVEKMNVfnTEVRSLSKVERANacnsvirqlmkkefTLEFSRDRKSMsvycs 499
Cdd:cd02080 324 CNDAQLHQED--GHWKITGDPTEGALLVLAAKAGL--DPDRLASSYPRVD--------------KIPFDSAYRYM----- 380
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 500 pAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTgpvKEKIMSVIKEWGtgRDTLRCLALATRDTPPKREEMVLD 579
Cdd:cd02080 381 -ATLHRDDGQRVIYVKGAPERLLDMCDQELLDGGVSPLD---RAYWEAEAEDLA--KQGLRVLAFAYREVDSEVEEIDHA 454
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 580 DSakfmeyEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSENeevtdRAYTGREFD 659
Cdd:cd02080 455 DL------EGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQLGLGDGK-----KVLTGAELD 523
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 660 DLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMVLADD 738
Cdd:cd02080 524 ALDDEELAEAVDEVDVFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGiKGTEVAKEAADMVLADD 603
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 739 NFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMD 818
Cdd:cd02080 604 NFATIAAAVEEGRRVYDNLKKFILFTLPTNLGEGLVIIVAILFGVTLPLTPVQILWINMVTAITLGLALAFEPAEPGIMK 683
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 819 RPPRSPKEPLISGWLFFR------YMAIGGYvgaatvgaaaWWFLYAEDGphvsyhqlthfmqctehnpefdGLDCEvfe 892
Cdd:cd02080 684 RPPRDPSEPLLSRELIWRillvslLMLGGAF----------GLFLWALDR----------------------GYSLE--- 728
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 893 apEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDFTQWLMVLK 972
Cdd:cd02080 729 --TARTMAVNTIVVAQIFYLFNCRSLHRSILKLGVFSNKILFLGIGALILLQLAFTYLPFMNSLFGTAPIDLVDWAIILL 806
                       970
                ....*....|...
gi 36031132 973 ISLPVIGLDELLK 985
Cdd:cd02080 807 VGIVVFIVVELEK 819
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
23-822 0e+00

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 730.18  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  23 GLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLawfeeGEEtvtafVEPFVILLILIANA 102
Cdd:cd02089   1 GLSEEEAERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVL-----GEY-----VDAIVIIAIVILNA 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 103 IVGVWQERNAENAIEALKEYEPEMGKVYRaDRKsVQRIKARDIVPGDIVEVAVGDKVPADIRIlsIKSTTLRVDQSILTG 182
Cdd:cd02089  71 VLGFVQEYKAEKALAALKKMSAPTAKVLR-DGK-KQEIPARELVPGDIVLLEAGDYVPADGRL--IESASLRVEESSLTG 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 183 ESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSK 262
Cdd:cd02089 147 ESEPVEKDADTLLEEDVPLGDRKNMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEETEEEKTPLQKRLDQLGKRLAI 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 263 VISLICVAVWLINIGHFNDPVH----GGSWFRGAIyyfkiavalavaaiPEGLPAVITTCLALGTRRMAKKNAIVRSLPS 338
Cdd:cd02089 227 AALIICALVFALGLLRGEDLLDmlltAVSLAVAAI--------------PEGLPAIVTIVLALGVQRMAKRNAIIRKLPA 292
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 339 VETLGCTSVICSDKTGTLTTNQMSVCKMFIIdkvdgdvcslnefsitgstyapegevlkndkpvragqydglvelatica 418
Cdd:cd02089 293 VETLGSVSVICSDKTGTLTQNKMTVEKIYTI------------------------------------------------- 323
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 419 lcndssldfnetkgvyekvGEATETALTTLVEKMNVFNTEvrslskveranacnsvIRQLMKKEFTLEFSRDRKSMSVyc 498
Cdd:cd02089 324 -------------------GDPTETALIRAARKAGLDKEE----------------LEKKYPRIAEIPFDSERKLMTT-- 366
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 499 spakSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEWGtgRDTLRCLALATRDTPpkreEMVL 578
Cdd:cd02089 367 ----VHKDAGKYIVFTKGAPDVLLPRCTYIYINGQVRPLTEEDRAKILAVNEEFS--EEALRVLAVAYKPLD----EDPT 436
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 579 DDSakfMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSENeevtDRAYTGREF 658
Cdd:cd02089 437 ESS---EDLENDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGILEDG----DKALTGEEL 509
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 659 DDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMVLAD 737
Cdd:cd02089 510 DKMSDEELEKKVEQISVYARVSPEHKLRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMGiTGTDVAKEAADMILTD 589
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 738 DNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIM 817
Cdd:cd02089 590 DNFATIVAAVEEGRTIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDIM 669

                ....*
gi 36031132 818 DRPPR 822
Cdd:cd02089 670 DRKPR 674
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
33-985 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 559.32  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  33 LEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEGEETVTAfvepfvillILIAnAIVGVWQERNA 112
Cdd:cd02085   2 RKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVA---------ILIV-VTVAFVQEYRS 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 113 ENAIEALKEYEPEMGKVYRADRksVQRIKARDIVPGDIVEVAVGDKVPADIRIlsIKSTTLRVDQSILTGESVSVIKHTD 192
Cdd:cd02085  72 EKSLEALNKLVPPECHCLRDGK--LEHFLARELVPGDLVCLSIGDRIPADLRL--FEATDLSIDESSLTGETEPCSKTTE 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 193 PVPDPRAVN-QDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSkVISLICVAV 271
Cdd:cd02085 148 VIPKASNGDlTTRSNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLS-LYSFIIIGV 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 272 WLInIGhfndpvhggsWFRGA--IYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVIC 349
Cdd:cd02085 227 IML-IG----------WLQGKnlLEMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVIC 295
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 350 SDKTGTLTTNQMSVCKMFiidkvdgdvcslnefsiTGstyapegevlkndkpvragqydglvelaticALCNDSSLDFNE 429
Cdd:cd02085 296 SDKTGTLTKNEMTVTKIV-----------------TG-------------------------------CVCNNAVIRNNT 327
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 430 TkgvyekVGEATETALTTLVEKMNVfnTEVRslskveranacNSVIRqlmKKEftLEFSRDRKSMSVYCSPAKSSRaavG 509
Cdd:cd02085 328 L------MGQPTEGALIALAMKMGL--SDIR-----------ETYIR---KQE--IPFSSEQKWMAVKCIPKYNSD---N 380
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 510 NKM-FVKGAPEGVIDRCNYVRVGT-TRVPLTGPVKEKIMSVIKEwgTGRDTLRCLALAtrdtppkreemvlddSAKFMEy 587
Cdd:cd02085 381 EEIyFMKGALEQVLDYCTTYNSSDgSALPLTQQQRSEINEEEKE--MGSKGLRVLALA---------------SGPELG- 442
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 588 emDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSeneeVTDRAYTGREFDDLPLAEQR 667
Cdd:cd02085 443 --DLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYS----PSLQALSGEEVDQMSDSQLA 516
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 668 EACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMVLADDNFSTIVAA 746
Cdd:cd02085 517 SVVRKVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGrTGTDVCKEAADMILVDDDFSTILAA 596
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 747 VEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKE 826
Cdd:cd02085 597 IEEGKGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKD 676
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 827 PLISG------------------WLFFRYMAIGGyvgaatvgaaawwflyaedgphvsyhqlthfmqctehnpefdgldc 888
Cdd:cd02085 677 PILTRslilnvllsaaiivsgtlWVFWKEMSDDN---------------------------------------------- 710
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 889 evfEAPEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDFTQWL 968
Cdd:cd02085 711 ---VTPRDTTMTFTCFVFFDMFNALSCRSQTKSIFEIGFFSNRMFLYAVGGSLIGQLLVIYFPPLQRVFQTEALGLLDLL 787
                       970
                ....*....|....*..
gi 36031132 969 MVLKISLPVIGLDELLK 985
Cdd:cd02085 788 FLLGLTSSVFIVSELRK 804
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
8-989 0e+00

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 550.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132     8 STEECLSYFGVSETTGLTPDQVKRHLEK-YGPNELPAEEGKSLWELVVEQF-EDLLVRILLLAACISFVLAWFEEGEEtv 85
Cdd:TIGR01522   8 SVEETCSKLQTDLQNGLNSSQEASHRRAfHGWNEFDVEEDESLWKKFLSQFvKNPLILLLIASAVISVFMGNIDDAVS-- 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    86 tafvepfVILLILIAnAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKsvQRIKARDIVPGDIVEVAVGDKVPADIRI 165
Cdd:TIGR01522  86 -------ITLAILIV-VTVGFVQEYRSEKSLEALNKLVPPECHLIREGKL--EHVLASTLVPGDLVCLSVGDRVPADLRI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   166 lsIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVN-QDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQ 244
Cdd:TIGR01522 156 --VEAVDLSIDESNLTGETTPVSKVTAPIPAATNGDlAERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIEK 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   245 DKTPLQQKLDEFGEQLSkVISLICVAVWLInIGHFndpvHGGSWFRgaiyYFKIAVALAVAAIPEGLPAVITTCLALGTR 324
Cdd:TIGR01522 234 PKTPLQKSMDLLGKQLS-LVSFGVIGVICL-VGWF----QGKDWLE----MFTISVSLAVAAIPEGLPIIVTVTLALGVL 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   325 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIidkVDGDVCSLNEFSItgstyaPEGEVLKNDKPVRA 404
Cdd:TIGR01522 304 RMSKKRAIVRKLPSVETLGSVNVICSDKTGTLTKNHMTVTKIWT---SDGLHTMLNAVSL------NQFGEVIVDGDVLH 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   405 GQYD-GLVELATICALCNDSSldFNETKGVYekVGEATETALTTLVEKMNVFNtevrslskveranacnsvIRQLMKKEF 483
Cdd:TIGR01522 375 GFYTvAVSRILEAGNLCNNAK--FRNEADTL--LGNPTDVALIELLMKFGLDD------------------LRETYIRVA 432
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   484 TLEFSRDRKSMSVYCSPAKSSRAAVgnkmFVKGAPEGVIDRCNYV--RVGTTrVPLTGPVKEKIMSVIKEWGTgrDTLRC 561
Cdd:TIGR01522 433 EVPFSSERKWMAVKCVHRQDRSEMC----FMKGAYEQVLKYCTYYqkKDGKT-LTLTQQQRDVIQEEAAEMAS--AGLRV 505
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   562 LALATRdtPPKREemvlddsakfmeyemdLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGI 641
Cdd:TIGR01522 506 IAFASG--PEKGQ----------------LTFLGLVGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETAVSIARRLGM 567
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   642 FSeneeVTDRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG 721
Cdd:TIGR01522 568 PS----KTSQSVSGEKLDAMDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADIGVAMG 643
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   722 -SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTD 800
Cdd:TIGR01522 644 qTGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWINILMD 723
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   801 GLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMaiggyvGAATVGAAAWWFLYAEDgphvsyhqlthfMQctehn 880
Cdd:TIGR01522 724 GPPAQSLGVEPVDKDVMRKPPRPRNDKILTKDLIKKIL------VSAIIIVVGTLFVFVRE------------MQ----- 780
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   881 pefDGLdcevfEAPEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLR 960
Cdd:TIGR01522 781 ---DGV-----ITARDTTMTFTCFVFFDMFNALACRSQTKSVFEIGFFSNRMFNYAVGGSIIGQLLVIYFPPLQSVFQTE 852
                         970       980
                  ....*....|....*....|....*....
gi 36031132   961 ALDFTQWLMVLKISLPVIGLDELLKFIAR 989
Cdd:TIGR01522 853 ALSIKDLLFLLLITSSVCIVDEIRKKVER 881
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
93-807 6.57e-174

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 518.03  E-value: 6.57e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    93 VILLILIANAIVGVWQERNAENAIEALKEYEpEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSiksTT 172
Cdd:TIGR01494   1 FILFLVLLFVLLEVKQKLKAEDALRSLKDSL-VNTATVLVLRNGWKEISSKDLVPGDVVLVKSGDTVPADGVLLS---GS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   173 LRVDQSILTGESVSVIKHTDPvpdpravnqdKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQK 252
Cdd:TIGR01494  77 AFVDESSLTGESLPVLKTALP----------DGDAVFAGTINFGGTLIVKVTATGILTTVGKIAVVVYTGFSTKTPLQSK 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   253 LDEFGEQL-SKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAValavaaiPEGLPAVITTCLALGTRRMAKKNA 331
Cdd:TIGR01494 147 ADKFENFIfILFLLLLALAVFLLLPIGGWDGNSIYKAILRALAVLVIAI-------PCALPLAVSVALAVGDARMAKKGI 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   332 IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGdvcslnefsitgstyapegevlkndkpvragqydglv 411
Cdd:TIGR01494 220 LVKNLNALEELGKVDVICFDKTGTLTTNKMTLQKVIIIGGVEE------------------------------------- 262
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   412 elaticalcnDSSLDFNETKGVYEKVGEATETALTTLVEKMNvfntevrslskveranaCNSVIRQLMKKEFTLEFSRDR 491
Cdd:TIGR01494 263 ----------ASLALALLAASLEYLSGHPLERAIVKSAEGVI-----------------KSDEINVEYKILDVFPFSSVL 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   492 KSMSVYCSPAKSSRaavgnKMFVKGAPEGVIDRCNYvrvgttrvpltgpvKEKIMSVIKEWgtGRDTLRCLALATRDTPP 571
Cdd:TIGR01494 316 KRMGVIVEGANGSD-----LLFVKGAPEFVLERCNN--------------ENDYDEKVDEY--ARQGLRVLAFASKKLPD 374
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   572 kreemvlddsakfmeyemDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFseneevtdr 651
Cdd:TIGR01494 375 ------------------DLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKELGID--------- 427
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   652 aytgrefddlplaeqreacrracCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGtAVAKTAS 731
Cdd:TIGR01494 428 -----------------------VFARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADVGIAMGSG-DVAKAAA 483
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 36031132   732 EMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAAlglpealipvqllwVNLVTDGLPATAL 807
Cdd:TIGR01494 484 DIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIV--------------IILLPPLLAALAL 545
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
23-989 1.38e-167

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 514.70  E-value: 1.38e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  23 GLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISF-VLAWFEEGeetvtafvepfVILLILIAN 101
Cdd:cd02086   1 GLTNDEAERRLKEYGENELEGDTGVSAWKILLRQVANAMTLVLIIAMALSFaVKDWIEGG-----------VIAAVIALN 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 102 AIVGVWQERNAENAIEALKEYEPEMGKVYRADrkSVQRIKARDIVPGDIVEVAVGDKVPADIRIlsIKSTTLRVDQSILT 181
Cdd:cd02086  70 VIVGFIQEYKAEKTMDSLRNLSSPNAHVIRSG--KTETISSKDVVPGDIVLLKVGDTVPADLRL--IETKNFETDEALLT 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 182 GESVSVIKHTDPV--PDPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATE---------------- 243
Cdd:cd02086 146 GESLPVIKDAELVfgKEEDVSVGDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKALRGKGglisrdrvkswlygtl 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 244 -------------QDKTPLQQKLDEFGEQLSkVISLIC-VAVWLINIGHFNDPVhggswfrgAIYyfkiAVALAVAAIPE 309
Cdd:cd02086 226 ivtwdavgrflgtNVGTPLQRKLSKLAYLLF-FIAVILaIIVFAVNKFDVDNEV--------IIY----AIALAISMIPE 292
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 310 GLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIdkvdgdvcslnefsitgsty 389
Cdd:cd02086 293 SLVAVLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVVRQVWIP-------------------- 352
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 390 apegevlkndkpvragqydglvelatiCALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVfntevRSLSKVERAN 469
Cdd:cd02086 353 ---------------------------AALCNIATVFKDEETDCWKAHGDPTEIALQVFATKFDM-----GKNALTKGGS 400
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 470 ACNSVIRqlmkkEFTleFSRDRKSMS-VYCSPAKSSRAAvgnkmFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSV 548
Cdd:cd02086 401 AQFQHVA-----EFP--FDSTVKRMSvVYYNNQAGDYYA-----YMKGAVERVLECCSSMYGKDGIIPLDDEFRKTIIKN 468
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 549 IKEWGTgrDTLRCLALATRDTPpkrEEMVLDDSAKFMEY-----EMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIM 623
Cdd:cd02086 469 VESLAS--QGLRVLAFASRSFT---KAQFNDDQLKNITLsradaESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHM 543
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 624 ITGDNKGTAIAICRRIGIFSENEEVTDRAY------TGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEI 697
Cdd:cd02086 544 LTGDHPGTAKAIAREVGILPPNSYHYSQEImdsmvmTASQFDGLSDEEVDALPVLPLVIARCSPQTKVRMIEALHRRKKF 623
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 698 TAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVvcIF 776
Cdd:cd02086 624 CAMTGDGVNDSPSLKMADVGIAMGlNGSDVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFVLHLLAENVAQV--IL 701
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 777 LTAALGLPEA-------LIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISgWLFFRYMAIGGYVGAATV 849
Cdd:cd02086 702 LLIGLAFKDEdglsvfpLSPVEILWINMVTSSFPAMGLGLEKASPDVMQRPPHDLKVGIFT-RELIIDTFVYGTFMGVLC 780
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 850 GAAAWWFLYAEDGPHVSYhqlthfmQCTEH-NPEfdgldCE-VFEAPEP--MTMALSVLVTiemcnALNSLSENQSLLRM 925
Cdd:cd02086 781 LASFTLVIYGIGNGDLGS-------DCNESyNSS-----CEdVFRARAAvfATLTWCALIL-----AWEVVDMRRSFFNM 843
                       970       980       990      1000      1010      1020      1030      1040
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 926 PP-------------WVNIWLLGSICLSMSLHFLILYVdplPMI----FKLRALDFtQWLMVLKISLPVIGLDELLKFIA 988
Cdd:cd02086 844 HPdtdspvksffktlWKNKFLFWSVVLGFVSVFPTLYI---PVInddvFKHTGIGW-EWGLVIACTVAFFAGVELWKAGK 919

                .
gi 36031132 989 R 989
Cdd:cd02086 920 R 920
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
29-830 1.69e-165

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 502.50  E-value: 1.69e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  29 VKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEE--GEETVTAFVEPFVILLILIANAIVGV 106
Cdd:cd02081   1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPfgEGEGKTGWIEGVAILVAVILVVLVTA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 107 WQERNAENAIEAL-KEYEPEMGKVYRADRksVQRIKARDIVPGDIVEVAVGDKVPADIRIlsIKSTTLRVDQSILTGESV 185
Cdd:cd02081  81 GNDYQKEKQFRKLnSKKEDQKVTVIRDGE--VIQISVFDIVVGDIVQLKYGDLIPADGLL--IEGNDLKIDESSLTGESD 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 186 SVIKHTDpvpdpravNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVIS 265
Cdd:cd02081 157 PIKKTPD--------NQIPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAENEEKTPLQEKLTKLAVQIGKVGL 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 266 LICVAVWLINIGHF--NDPVHGGSWFRGA-----IYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPS 338
Cdd:cd02081 229 IVAALTFIVLIIRFiiDGFVNDGKSFSAEdlqefVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDA 308
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 339 VETLGCTSVICSDKTGTLTTNQMSVCKMFIidkvdgdvcslnefsitgstyapegevlkndkpvragqydglvelatica 418
Cdd:cd02081 309 CETMGNATAICSDKTGTLTQNRMTVVQGYI-------------------------------------------------- 338
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 419 lcndssldfnetkgvyekvGEATETALTTLVEKmnvfnteVRSLSKVERANACNSVIRQlmkkeFTleFSRDRKSMSVyc 498
Cdd:cd02081 339 -------------------GNKTECALLGFVLE-------LGGDYRYREKRPEEKVLKV-----YP--FNSARKRMST-- 383
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 499 spakssraAVGNK-----MFVKGAPEGVIDRCNYVRVGT-TRVPLTGPVKEKIMSVIKEWGtgRDTLRCLALATRDTPPK 572
Cdd:cd02081 384 --------VVRLKdggyrLYVKGASEIVLKKCSYILNSDgEVVFLTSEKKEEIKRVIEPMA--SDSLRTIGLAYRDFSPD 453
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 573 REEMVLDDSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSENEEvtDRA 652
Cdd:cd02081 454 EEPTAERDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGED--GLV 531
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 653 YTGREFDDLPLAEQREACRRACCF--------ARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG-SG 723
Cdd:cd02081 532 LEGKEFRELIDEEVGEVCQEKFDKiwpklrvlARSSPEDKYTLVKGLKDSGEVVAVTGDGTNDAPALKKADVGFAMGiAG 611
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 724 TAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLP 803
Cdd:cd02081 612 TEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLA 691
                       810       820
                ....*....|....*....|....*..
gi 36031132 804 ATALGFNPPDLDIMDRPPRSPKEPLIS 830
Cdd:cd02081 692 ALALATEPPTEDLLKRKPYGRDKPLIS 718
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
24-830 1.88e-133

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 426.12  E-value: 1.88e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    24 LTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLAWF-----EEGEETVTAFVEPFVILL-I 97
Cdd:TIGR01517  62 LSSSTLERREKVYGKNELPEKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYvpsvgEDKADTETGWIEGVAILVsV 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    98 LIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRksVQRIKARDIVPGDIVEVAVGDKVPADIriLSIKSTTLRVDQ 177
Cdd:TIGR01517 142 ILVVLVTAVNDYKKELQFRQLNREKSAQKIAVIRGGQ--EQQISIHDIVVGDIVSLSTGDVVPADG--VFISGLSLEIDE 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   178 SILTGESvsvikhtdpvpDPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFG 257
Cdd:TIGR01517 218 SSITGES-----------DPIKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAGEEETPLQEKLSELA 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   258 EQLSK-------VISLICVAVWLINI----GHFNDPVHGGSWFrgaIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRM 326
Cdd:TIGR01517 287 GLIGKfgmgsavLLFLVLSLRYVFRIirgdGRFEDTEEDAQTF---LDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKM 363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   327 AKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVdgdvcslnefsitgSTYAPEGEVLKNDKPVRagq 406
Cdd:TIGR01517 364 MKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQR--------------FNVRDEIVLRNLPAAVR--- 426
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   407 yDGLVElatiCALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRSLSKVERANAcnsvirqlmkkefTLE 486
Cdd:TIGR01517 427 -NILVE----GISLNSSSEEVVDRGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVK-------------IYP 488
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   487 FSRDRKSMSVYCS-PAKSSRAavgnkmFVKGAPEGVIDRCNYVR-VGTTRVPLTGPVKEKIMSVIKEWGTgrDTLRCLAL 564
Cdd:TIGR01517 489 FNSERKFMSVVVKhSGGKYRE------FRKGASEIVLKPCRKRLdSNGEATPISEDDKDRCADVIEPLAS--DALRTICL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   565 ATRDTPPKreemvlddSAKFMEYEMD-LTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFS 643
Cdd:TIGR01517 561 AYRDFAPE--------EFPRKDYPNKgLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILT 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   644 ENEEVTDraytGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG-S 722
Cdd:TIGR01517 633 FGGLAME----GKEFRSLVYEEMDPILPKLRVLARSSPLDKQLLVLMLKDMGEVVAVTGDGTNDAPALKLADVGFSMGiS 708
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   723 GTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEA--LIPVQLLWVNLVTD 800
Cdd:TIGR01517 709 GTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISSSHTspLTAVQLLWVNLIMD 788
                         810       820       830
                  ....*....|....*....|....*....|
gi 36031132   801 GLPATALGFNPPDLDIMDRPPRSPKEPLIS 830
Cdd:TIGR01517 789 TLAALALATEPPTEALLDRKPIGRNAPLIS 818
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
3-841 1.00e-130

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 421.34  E-value: 1.00e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132      3 AAHSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLA-WFEEG 81
Cdd:TIGR01523    6 AYFSDIADEAAEFIGTSIPEGLTHDEAQHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISFAMHdWIEGG 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132     82 eetvtafvepfVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKsvQRIKARDIVPGDIVEVAVGDKVPA 161
Cdd:TIGR01523   86 -----------VISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAHVIRNGKS--DAIDSHDLVPGDICLLKTGDTIPA 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    162 DIRIlsIKSTTLRVDQSILTGESVSVIKhtdpvpDPRAVNQ--------DKKNMLFSGTNIAAGKAVGIVATTGVSTEIG 233
Cdd:TIGR01523  153 DLRL--IETKNFDTDEALLTGESLPVIK------DAHATFGkeedtpigDRINLAFSSSAVTKGRAKGICIATALNSEIG 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    234 KI----------------RDQMAATEQDK-------------------TPLQQKLDEFGeqlskvISLICVAVWLINIGH 278
Cdd:TIGR01523  225 AIaaglqgdgglfqrpekDDPNKRRKLNKwilkvtkkvtgaflglnvgTPLHRKLSKLA------VILFCIAIIFAIIVM 298
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    279 FNDPVHGGSwfRGAIYyfkiAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTT 358
Cdd:TIGR01523  299 AAHKFDVDK--EVAIY----AICLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQ 372
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    359 NQMSVCKMFI-------IDKVD-------GDVCSLNEFSITGSTYAPEG--EVLKN--------DKPVRAGQyDGLVELA 414
Cdd:TIGR01523  373 GKMIARQIWIprfgtisIDNSDdafnpneGNVSGIPRFSPYEYSHNEAAdqDILKEfkdelkeiDLPEDIDM-DLFIKLL 451
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    415 TICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRSLSKVERANACN-SVIRQLMKK------EFTLEF 487
Cdd:TIGR01523  452 ETAALANIATVFKDDATDCWKAHGDPTEIAIHVFAKKFDLPHNALTGEEDLLKSNENDqSSLSQHNEKpgsaqfEFIAEF 531
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    488 SRDR--KSMSVYCSPAKSSRAAVgnkmFVKGAPEGVIDRCN--YVRVGTTRVPLTGPVKEKIMSVIkeWGTGRDTLRCLA 563
Cdd:TIGR01523  532 PFDSeiKRMASIYEDNHGETYNI----YAKGAFERIIECCSssNGKDGVKISPLEDCDRELIIANM--ESLAAEGLRVLA 605
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    564 LATR--DTPPKREEMVLDDSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGI 641
Cdd:TIGR01523  606 FASKsfDKADNNDDQLKNETLNRATAESDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGI 685
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    642 FSEN------EEVTDRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAE 715
Cdd:TIGR01523  686 IPPNfihdrdEIMDSMVMTGSQFDALSDEEVDDLKALCLVIARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLKMAN 765
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    716 IGIAMG-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVvcIFLTAALGLPE-------AL 787
Cdd:TIGR01523  766 VGIAMGiNGSDVAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLAENVAEA--ILLIIGLAFRDengksvfPL 843
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|....
gi 36031132    788 IPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIG 841
Cdd:TIGR01523  844 SPVEILWCIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGIFQKELIIDMFAYG 897
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
36-807 3.02e-130

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 407.96  E-value: 3.02e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  36 YGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLAwfeegeetvtAFVEPFVILLILIANAIVGVWQERNAENA 115
Cdd:cd07539  15 PARNLALETATRSGILAVAAQLELPPVALLGLAAGASASTG----------GGVDAVLIVGVLTVNAVIGGVQRLRAERA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 116 IEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSikSTTLRVDQSILTGESVSVIKHTDPVP 195
Cdd:cd07539  85 LAALLAQQQQPARVVRAPAGRTQTVPAESLVPGDVIELRAGEVVPADARLLE--ADDLEVDESALTGESLPVDKQVAPTP 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 196 dpRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRdQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWlin 275
Cdd:cd07539 163 --GAPLADRACMLYEGTTVVSGQGRAVVVATGPHTEAGRAQ-SLVAPVETATGVQAQLRELTSQLLPLSLGGGAAVT--- 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 276 ighfndpvhGGSWFRGA--IYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKT 353
Cdd:cd07539 237 ---------GLGLLRGAplRQAVADGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDKT 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 354 GTLTTNQMSVckmfiidkvdgdvcslnefsitGSTYAPEGEVlkndkPVRAGQydglVELATIcalcndssldfnetkgv 433
Cdd:cd07539 308 GTLTENRLRV----------------------VQVRPPLAEL-----PFESSR----GYAAAI----------------- 339
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 434 yekVGEATETALTTlvekmnvfntevrslskveranacnsvirqlmkkeftlefsrdrksmsvycspakssraavgnkmf 513
Cdd:cd07539 340 ---GRTGGGIPLLA------------------------------------------------------------------ 350
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 514 VKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEwgTGRDTLRCLALATRdTPPKREEMVLDDSAKfmeyemDLTF 593
Cdd:cd07539 351 VKGAPEVVLPRCDRRMTGGQVVPLTEADRQAIEEVNEL--LAGQGLRVLAVAYR-TLDAGTTHAVEAVVD------DLEL 421
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 594 VGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIfSENEEVTDraytGREFDDLPLAEQREACRRA 673
Cdd:cd07539 422 LGLLGLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGL-PRDAEVVT----GAELDALDEEALTGLVADI 496
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 674 CCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKTASEMVLADDNFSTIVAAVEEGRA 752
Cdd:cd07539 497 DVFARVSPEQKLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVGArGSDAAREAADLVLTDDDLETLLDAVVEGRT 576
                       730       740       750       760       770
                ....*....|....*....|....*....|....*....|....*....|....*
gi 36031132 753 IYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATAL 807
Cdd:cd07539 577 MWQNVRDAVHVLLGGNLGEVMFTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALAL 631
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
5-841 1.22e-129

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 416.89  E-value: 1.22e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132     5 HSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEGEET 84
Cdd:TIGR01106  18 HKLSLDELERKYGTDLSKGLSAARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQASTEE 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    85 VTAFVEPF---VILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKsvQRIKARDIVPGDIVEVAVGDKVPA 161
Cdd:TIGR01106  98 EPQNDNLYlgvVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRDGEK--MSINAEQVVVGDLVEVKGGDRIPA 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   162 DIRILSIKSttLRVDQSILTGESVsvikhtdpvPDPRAVN------QDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKI 235
Cdd:TIGR01106 176 DLRIISAQG--CKVDNSSLTGESE---------PQTRSPEfthenpLETRNIAFFSTNCVEGTARGIVVNTGDRTVMGRI 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   236 RDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIghfndpVHGGSWFRGAIYYFkiavALAVAAIPEGLPAVI 315
Cdd:TIGR01106 245 ASLASGLENGKTPIAIEIEHFIHIITGVAVFLGVSFFILSL------ILGYTWLEAVIFLI----GIIVANVPEGLLATV 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   316 TTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIidkvdgDvcslNEFSITGSTYAPEGEV 395
Cdd:TIGR01106 315 TVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWF------D----NQIHEADTTEDQSGVS 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   396 LKNDKPvragqydGLVELATICALCNDSSLDFN-ETKGVYEK--VGEATETALTTLVEKmnvfntevrslskveranACN 472
Cdd:TIGR01106 385 FDKSSA-------TWLALSRIAGLCNRAVFKAGqENVPILKRavAGDASESALLKCIEL------------------CLG 439
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   473 SV--IRQLMKKEFTLEF-SRDRKSMSVYCSPAKSSRAAVgnkMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVI 549
Cdd:TIGR01106 440 SVmeMRERNPKVVEIPFnSTNKYQLSIHENEDPRDPRHL---LVMKGAPERILERCSSILIHGKEQPLDEELKEAFQNAY 516
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   550 KEWG-TGRDTLR-CLALATRDTPPKREEMVLDDsakfMEYEMD-LTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITG 626
Cdd:TIGR01106 517 LELGgLGERVLGfCHLYLPDEQFPEGFQFDTDD----VNFPTDnLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTG 592
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   627 DNKGTAIAICRRIGIFSE-NEEVTDRAY-------------------TGREFDDLPLAEQREACR--RACCFARVEPSHK 684
Cdd:TIGR01106 593 DHPITAKAIAKGVGIISEgNETVEDIAArlnipvsqvnprdakacvvHGSDLKDMTSEQLDEILKyhTEIVFARTSPQQK 672
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   685 SKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRY 763
Cdd:TIGR01106 673 LIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAY 752
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   764 LISSNVGEVV--CIFLTAALGLPeaLIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPK------EPLISgwlfF 835
Cdd:TIGR01106 753 TLTSNIPEITpfLIFIIANIPLP--LGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPKtdklvnERLIS----M 826

                  ....*.
gi 36031132   836 RYMAIG 841
Cdd:TIGR01106 827 AYGQIG 832
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
23-841 1.59e-128

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 411.74  E-value: 1.59e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  23 GLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEGEETvtafvEP--------FVI 94
Cdd:cd02608   1 GLTSARAAEILARDGPNALTPPPTTPEWVKFCKQLFGGFSMLLWIGAILCFLAYGIQAATEE-----EPsndnlylgIVL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  95 LLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKsvQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSttLR 174
Cdd:cd02608  76 AAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEK--MQINAEELVVGDLVEVKGGDRIPADIRIISAHG--CK 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 175 VDQSILTGESVsvikhtdpvPDPRAVN------QDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTP 248
Cdd:cd02608 152 VDNSSLTGESE---------PQTRSPEfthenpLETKNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGKTP 222
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 249 LQQKLDEFGEQLSKVISLICVAVWLINIghfndpVHGGSWFRGAIYYFkiavALAVAAIPEGLPAVITTCLALGTRRMAK 328
Cdd:cd02608 223 IAREIEHFIHIITGVAVFLGVSFFILSL------ILGYTWLEAVIFLI----GIIVANVPEGLLATVTVCLTLTAKRMAR 292
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 329 KNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDK-VDGDVC---SLNEFSITGSTYApegevlkndkpvra 404
Cdd:cd02608 293 KNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQiHEADTTedqSGASFDKSSATWL-------------- 358
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 405 gqydglvELATICALCNDSSLDFN-ETKGVYEKV--GEATETALTTLVEkmnvfntevrsLSkveranaCNSV--IRQLM 479
Cdd:cd02608 359 -------ALSRIAGLCNRAEFKAGqENVPILKRDvnGDASESALLKCIE-----------LS-------CGSVmeMRERN 413
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 480 KKEFTLEF-SRDRKSMSVYCSPAKSSRaavGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEWG-TGRD 557
Cdd:cd02608 414 PKVAEIPFnSTNKYQLSIHENEDPGDP---RYLLVMKGAPERILDRCSTILINGKEQPLDEEMKEAFQNAYLELGgLGER 490
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 558 TLR-C-LALATRDTPPkreemvlddSAKFMEYEM-----DLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKG 630
Cdd:cd02608 491 VLGfChLYLPDDKFPE---------GFKFDTDEVnfpteNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPI 561
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 631 TAIAICRRIGIFseneevtdraytgrefddlplaeqreacrracCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPA 710
Cdd:cd02608 562 TAKAIAKGVGII--------------------------------VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPA 609
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 711 LKKAEIGIAMG-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIP 789
Cdd:cd02608 610 LKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGT 689
                       810       820       830       840       850
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 36031132 790 VQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPK------EPLISgwlfFRYMAIG 841
Cdd:cd02608 690 ITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPKtdklvnERLIS----MAYGQIG 743
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
23-841 3.76e-128

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 402.98  E-value: 3.76e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  23 GLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEGeetvtAFVEPFVILLILIAna 102
Cdd:cd07538   1 GLTEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVLGDPREG-----LILLIFVVVIIAIE-- 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 103 ivgVWQERNAENAIEALKEYEPEMGKVYRADRKsvQRIKARDIVPGDIVEVAVGDKVPADIRILsiKSTTLRVDQSILTG 182
Cdd:cd07538  74 ---VVQEWRTERALEALKNLSSPRATVIRDGRE--RRIPSRELVPGDLLILGEGERIPADGRLL--ENDDLGVDESTLTG 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 183 ESVSVIKHTDPVPDpRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQ---KLDEFGEQ 259
Cdd:cd07538 147 ESVPVWKRIDGKAM-SAPGGWDKNFCYAGTLVVRGRGVAKVEATGSRTELGKIGKSLAEMDDEPTPLQKqtgRLVKLCAL 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 260 LSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIyyfkiavalavaaIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSV 339
Cdd:cd07538 226 AALVFCALIVAVYGVTRGDWIQAILAGITLAMAM-------------IPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAV 292
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 340 ETLGCTSVICSDKTGTLTTNQMSVCKMFIIdkvdgdvcsLNEFSitgstyapegevlkndkpvragqydglvelatical 419
Cdd:cd07538 293 ETLGSITVLCVDKTGTLTKNQMEVVELTSL---------VREYP------------------------------------ 327
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 420 cndssldfnetkgvyekvgeatetalttlvekmnvFNTEVRSLSKVERanacnsvirqlmkkeftlefsrdrksmsvycS 499
Cdd:cd07538 328 -----------------------------------LRPELRMMGQVWK-------------------------------R 341
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 500 PAKSSRAAvgnkmfvKGAPEGVIDRCNyvrvgttrvpLTGPVKEKIMSVIKEwgTGRDTLRCLALATRDT-----PPKRE 574
Cdd:cd07538 342 PEGAFAAA-------KGSPEAIIRLCR----------LNPDEKAAIEDAVSE--MAGEGLRVLAVAACRIdesflPDDLE 402
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 575 EMVLDdsakfmeyemdltFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIfSENEEVTdrayT 654
Cdd:cd07538 403 DAVFI-------------FVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQIGL-DNTDNVI----T 464
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 655 GREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKTASEM 733
Cdd:cd07538 465 GQELDAMSDEELAEKVRDVNIFARVVPEQKLRIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIAMGKrGTDVAREASDI 544
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 734 VLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDglPATALGF--NP 811
Cdd:cd07538 545 VLLDDNFSSIVSTIRLGRRIYDNLKKAITYVFAIHVPIAGLALLPPLLGLPPLLFPVHVVLLELIID--PTCSIVFeaEP 622
                       810       820       830
                ....*....|....*....|....*....|
gi 36031132 812 PDLDIMDRPPRSPKEPLISGWLFFRYMAIG 841
Cdd:cd07538 623 AERDIMRRPPRPPDEPLFGPRLVIKAILQG 652
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
23-800 3.50e-115

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 372.35  E-value: 3.50e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  23 GLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVL-AWFEEGEETVTAFvepFVILLILIAN 101
Cdd:cd02077   1 GLTNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTdVLLAPGEFDLVGA---LIILLMVLIS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 102 AIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSvQRIKARDIVPGDIVEVAVGDKVPADIRIlsIKSTTLRVDQSILT 181
Cdd:cd02077  78 GLLDFIQEIRSLKAAEKLKKMVKNTATVIRDGSKY-MEIPIDELVPGDIVYLSAGDMIPADVRI--IQSKDLFVSQSSLT 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 182 GESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIrDQMAATEQDKTPLQQKLDEFGEQLS 261
Cdd:cd02077 155 GESEPVEKHATAKKTKDESILELENICFMGTNVVSGSALAVVIATGNDTYFGSI-AKSITEKRPETSFDKGINKVSKLLI 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 262 KVISLICVAVWLINIghfndpVHGGSWFRGAIYyfkiAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVET 341
Cdd:cd02077 234 RFMLVMVPVVFLING------LTKGDWLEALLF----ALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQN 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 342 LGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGD----VCSLNEFSITGstyapegevLKNdkpvragqydgLVELATIC 417
Cdd:cd02077 304 FGAMDILCTDKTGTLTQDKIVLERHLDVNGKESErvlrLAYLNSYFQTG---------LKN-----------LLDKAIID 363
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 418 ALCNDSsldFNETKGVYEKVGEatetalttlvekmnvfntevrslskveranacnsvirqlmkkeftLEFSRDRKSMSVY 497
Cdd:cd02077 364 HAEEAN---ANGLIQDYTKIDE---------------------------------------------IPFDFERRRMSVV 395
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 498 CSPAKSSRaavgnKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEWgtGRDTLRCLALATRDTPPKREEMV 577
Cdd:cd02077 396 VKDNDGKH-----LLITKGAVEEILNVCTHVEVNGEVVPLTDTLREKILAQVEEL--NREGLRVLAIAYKKLPAPEGEYS 468
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 578 LDDsakfmeyEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIfseneeVTDRAYTGRE 657
Cdd:cd02077 469 VKD-------EKELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQVGL------DINRVLTGSE 535
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 658 FDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLAD 737
Cdd:cd02077 536 IEALSDEELAKIVEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDGINDAPALRQADVGISVDSAVDIAKEAADIILLE 615
                       730       740       750       760       770       780
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 36031132 738 DNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIfLTAALGLP-EALIPVQLLWVNLVTD 800
Cdd:cd02077 616 KDLMVLEEGVIEGRKTFGNILKYIKMTASSNFGNVFSV-LVASAFLPfLPMLPIQLLLQNLLYD 678
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
23-780 1.65e-106

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 349.22  E-value: 1.65e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  23 GLTPDQVKRHLEKYGPNELPAEEgKSLWELVVEQFEDLLVRILLLAACISFVLA-WFEegeetvtaFVepfVILLILIAN 101
Cdd:cd02076   1 GLTSEEAAKRLKEYGPNELPEKK-ENPILKFLSFFWGPIPWMLEAAAILAAALGdWVD--------FA---IILLLLLIN 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 102 AIVGVWQERNAENAIEALKEYEPEMGKVYRADRksVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKstTLRVDQSILT 181
Cdd:cd02076  69 AGIGFIEERQAGNAVAALKKSLAPKARVLRDGQ--WQEIDAKELVPGDIVSLKIGDIVPADARLLTGD--ALQVDQSALT 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 182 GESVSVIKHtdpvpdpravnqdKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQdKTPLQQKLDEFGEQLS 261
Cdd:cd02076 145 GESLPVTKH-------------PGDEAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVASAEE-QGHLQKVLNKIGNFLI 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 262 KVISLICVAVWLINIGHFNDPVHGGSW----FRGAIyyfkiavalavaaiPEGLPAVITTCLALGTRRMAKKNAIVRSLP 337
Cdd:cd02076 211 LLALILVLIIVIVALYRHDPFLEILQFvlvlLIASI--------------PVAMPAVLTVTMAVGALELAKKKAIVSRLS 276
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 338 SVETLGCTSVICSDKTGTLTTNQMSVckmfiidkvdGDVCSLNEFsitgstyaPEGEVLKndkpvragqydglveLAtic 417
Cdd:cd02076 277 AIEELAGVDILCSDKTGTLTLNKLSL----------DEPYSLEGD--------GKDELLL---------------LA--- 320
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 418 ALCNDssldfnetkgvyEKVGEATETAlttlvekmnVFNtevrSLSKVERANACnsvIRQLMKKEFTLEfsrDRKSMSVY 497
Cdd:cd02076 321 ALASD------------TENPDAIDTA---------ILN----ALDDYKPDLAG---YKQLKFTPFDPV---DKRTEATV 369
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 498 CSPAkssraavGNKMFV-KGAPEGVIDRCNYVRVGTTRvpltgpVKEKIMSVIKewgTGrdtLRCLALAtRDTPPKREEM 576
Cdd:cd02076 370 EDPD-------GERFKVtKGAPQVILELVGNDEAIRQA------VEEKIDELAS---RG---YRSLGVA-RKEDGGRWEL 429
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 577 vlddsakfmeyemdltfVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSeNEEVTDRAYTGR 656
Cdd:cd02076 430 -----------------LGLLPLFDPPRPDSKATIARAKELGVRVKMITGDQLAIAKETARQLGMGT-NILSAERLKLGG 491
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 657 EFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLA 736
Cdd:cd02076 492 GGGGMPGSELIEFIEDADGFAEVFPEHKYRIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAVSGATDAARAAADIVLT 571
                       730       740       750       760
                ....*....|....*....|....*....|....*....|....
gi 36031132 737 DDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVgeVVCIFLTAA 780
Cdd:cd02076 572 APGLSVIIDAIKTSRQIFQRMKSYVIYRIAETL--RILVFFTLG 613
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
483-807 1.58e-105

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 331.34  E-value: 1.58e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 483 FTLEFSRDRKSMSVYCSPAKSSRaavgnkMFVKGAPEGVIDRCNYvrvgttrvPLTGPVKEKIMSVIKEWGtgRDTLRCL 562
Cdd:cd01431  23 EEIPFNSTRKRMSVVVRLPGRYR------AIVKGAPETILSRCSH--------ALTEEDRNKIEKAQEESA--REGLRVL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 563 ALATRDTPPKREEMvlddsakfmEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIF 642
Cdd:cd01431  87 ALAYREFDPETSKE---------AVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLTAIAIAREIGID 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 643 SENEEVTdrayTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGS 722
Cdd:cd01431 158 TKASGVI----LGEEADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARGEVVAMTGDGVNDAPALKQADVGIAMGS 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 723 -GTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDG 801
Cdd:cd01431 234 tGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIALALFLGGPLPLLAFQILWINLVTDL 313

                ....*.
gi 36031132 802 LPATAL 807
Cdd:cd01431 314 IPALAL 319
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
23-801 1.33e-101

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 335.45  E-value: 1.33e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    23 GLTPDQVKRHLEKYGPNELPaEEGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEgeetvtaFVepfVILLILIANA 102
Cdd:TIGR01647   1 GLTSAEAKKRLAKYGPNELP-EKKVSPLLKFLGFFWNPLSWVMEAAAIIAIALENWVD-------FV---IILGLLLLNA 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   103 IVGVWQERNAENAIEALKEYEPEMGKVYRaDRKSVQrIKARDIVPGDIVEVAVGDKVPADIRILSikSTTLRVDQSILTG 182
Cdd:TIGR01647  70 TIGFIEENKAGNAVEALKQSLAPKARVLR-DGKWQE-IPASELVPGDVVRLKIGDIVPADCRLFE--GDYIQVDQAALTG 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   183 ESVSVIKHTDpvpdpravnqdkkNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSK 262
Cdd:TIGR01647 146 ESLPVTKKTG-------------DIAYSGSTVKQGEAEAVVTATGMNTFFGKAAALVQSTETGSGHLQKILSKIGLFLIV 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   263 VISLICVAVWLINIGHFNDPVHGGSWFR-----GAIyyfkiavalavaaiPEGLPAVITTCLALGTRRMAKKNAIVRSLP 337
Cdd:TIGR01647 213 LIGVLVLIELVVLFFGRGESFREGLQFAlvllvGGI--------------PIAMPAVLSVTMAVGAAELAKKKAIVTRLT 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   338 SVETLGCTSVICSDKTGTLTTNQMsvckmfiidkvdgdvcSLNEFSITGSTYAPEgevlkndkpvragqyDGLVELATIC 417
Cdd:TIGR01647 279 AIEELAGMDILCSDKTGTLTLNKL----------------SIDEILPFFNGFDKD---------------DVLLYAALAS 327
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   418 ALCNDSSLDFnetkGVYEKVGEATETALTTLVEKMNVFntevrslskveranacNSVIRqlmKKEFTLEFSRDRKSMSVy 497
Cdd:TIGR01647 328 REEDQDAIDT----AVLGSAKDLKEARDGYKVLEFVPF----------------DPVDK---RTEATVEDPETGKRFKV- 383
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   498 cspakssraavgnkmfVKGAPEGVIDRCNyvrvgtTRVPLTGPVKEKIMSVIKEwgtgrdTLRCLALATRDTPPKREemv 577
Cdd:TIGR01647 384 ----------------TKGAPQVILDLCD------NKKEIEEKVEEKVDELASR------GYRALGVARTDEEGRWH--- 432
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   578 lddsakfmeyemdltFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIfSENEEVTDRAYTGRE 657
Cdd:TIGR01647 433 ---------------FLGLLPLFDPPRHDTKETIERARHLGVEVKMVTGDHLAIAKETARRLGL-GTNIYTADVLLKGDN 496
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   658 FDDLPLAEQrEACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLAD 737
Cdd:TIGR01647 497 RDDLPSGLG-EMVEDADGFAEVFPEHKYEIVEILQKRGHLVGMTGDGVNDAPALKKADVGIAVAGATDAARSAADIVLTE 575
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 36031132   738 DNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVgEVVCIFLTAALGLPEALIPVQLLWVNLVTDG 801
Cdd:TIGR01647 576 PGLSVIVDAILESRKIFQRMKSYVIYRIAETI-RIVFFFGLLILILNFYFPPIMVVIIAILNDG 638
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
9-822 3.04e-93

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 316.24  E-value: 3.04e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    9 TEECLSYFGvSETTGLTPDQVKRHLEKYGPNELPAEEG----KSLWELVVEQFEDLLVrilLLAAcISFVlawfeegEET 84
Cdd:PRK10517  54 EEELWKTFD-THPEGLNEAEVESAREQHGENELPAQKPlpwwVHLWVCYRNPFNILLT---ILGA-ISYA-------TED 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   85 VTAFVepfVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRAD----RKSVQRIKARDIVPGDIVEVAVGDKVP 160
Cdd:PRK10517 122 LFAAG---VIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRVIndkgENGWLEIPIDQLVPGDIIKLAAGDMIP 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  161 ADIRILSIKSttLRVDQSILTGESVSVIKhtdpVPDPRAVNQ----DKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIR 236
Cdd:PRK10517 199 ADLRILQARD--LFVAQASLTGESLPVEK----FATTRQPEHsnplECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLA 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  237 DQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINiGHFNdpvhgGSWFRGAIYyfkiAVALAVAAIPEGLPAVIT 316
Cdd:PRK10517 273 GRVSEQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLIN-GYTK-----GDWWEAALF----ALSVAVGLTPEMLPMIVT 342
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  317 TCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNqmsvcKMFIIDKVD--GDVCS-------LNEFSITGs 387
Cdd:PRK10517 343 STLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQD-----KIVLENHTDisGKTSErvlhsawLNSHYQTG- 416
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  388 tyapegevLKNdkpvragqydgLVELAticalcndssldfnetkgVYEKVGEATETALTTLVEKMNvfntevrslskver 467
Cdd:PRK10517 417 --------LKN-----------LLDTA------------------VLEGVDEESARSLASRWQKID-------------- 445
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  468 anacnsvirqlmkkEFTLEFSRDRKSMSVycspakSSRAAVgNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMS 547
Cdd:PRK10517 446 --------------EIPFDFERRRMSVVV------AENTEH-HQLICKGALEEILNVCSQVRHNGEIVPLDDIMLRRIKR 504
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  548 VIKEWGtgRDTLRCLALATRDTPPKREEMVLDDsakfmeyEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGD 627
Cdd:PRK10517 505 VTDTLN--RQGLRVVAVATKYLPAREGDYQRAD-------ESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGD 575
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  628 NKGTAIAICRRIGIfseneeVTDRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVND 707
Cdd:PRK10517 576 SELVAAKVCHEVGL------DAGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTLLKREGHVVGFMGDGIND 649
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  708 APALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAAL--GLPe 785
Cdd:PRK10517 650 APALRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNFGNVFSVLVASAFlpFLP- 728
                        810       820       830
                 ....*....|....*....|....*....|....*..
gi 36031132  786 aLIPVQLLWVNLVTDgLPATALGFNPPDLDIMDRPPR 822
Cdd:PRK10517 729 -MLPLHLLIQNLLYD-VSQVAIPFDNVDDEQIQKPQR 763
ATPase-IIIB_Mg TIGR01524
magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ...
1-822 6.48e-86

magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130587 [Multi-domain]  Cd Length: 867  Bit Score: 295.62  E-value: 6.48e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132     1 MEAAHSKStEECLSYFGVSETtGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVlawfee 80
Cdd:TIGR01524  13 LKESQMGK-ETLLRKLGVHET-GLTNVEVTERLAEFGPNQTVEEKKVPNLRLLIRAFNNPFIYILAMLMGVSYL------ 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    81 gEETVTAFVepfVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRK----SVQRIKARDIVPGDIVEVAVG 156
Cdd:TIGR01524  85 -TDDLEATV---IIALMVLASGLLGFIQESRAERAAYALKNMVKNTATVLRVINEngngSMDEVPIDALVPGDLIELAAG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   157 DKVPADIRILSikSTTLRVDQSILTGESVSVIKHtDPVPDPRAVNQ-DKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKI 235
Cdd:TIGR01524 161 DIIPADARVIS--ARDLFINQSALTGESLPVEKF-VEDKRARDPEIlERENLCFMGTNVLSGHAQAVVLATGSSTWFGSL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   236 RDQMAATEQDkTPLQQKLDEFGEQLSKVISLICVAVWLINighfndPVHGGSWFRGAIYyfkiAVALAVAAIPEGLPAVI 315
Cdd:TIGR01524 238 AIAATERRGQ-TAFDKGVKSVSKLLIRFMLVMVPVVLMIN------GLMKGDWLEAFLF----ALAVAVGLTPEMLPMIV 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   316 TTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNqmsvcKMFIIDKVDgdvcslnefsitgSTYAPEGEV 395
Cdd:TIGR01524 307 SSNLAKGAINMSKKKVIVKELSAIQNFGAMDILCTDKTGTLTQD-----KIELEKHID-------------SSGETSERV 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   396 LKndkpvragqydglvelatiCALCNDSSldfnetkgvyekvgeatETALTtlvekmNVFNTEVrsLSKVERANACNSVI 475
Cdd:TIGR01524 369 LK-------------------MAWLNSYF-----------------QTGWK------NVLDHAV--LAKLDESAARQTAS 404
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   476 RqlMKKEFTLEFSRDRKSMSVYCSPAKSSRaavgnKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEWgtG 555
Cdd:TIGR01524 405 R--WKKVDEIPFDFDRRRLSVVVENRAEVT-----RLICKGAVEEMLTVCTHKRFGGAVVTLSESEKSELQDMTAEM--N 475
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   556 RDTLRCLALATRDTPPKREEMVLDDsakfmeyEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAI 635
Cdd:TIGR01524 476 RQGIRVIAVATKTLKVGEADFTKTD-------EEQLIIEGFLGFLDPPKESTKEAIAALFKNGINVKVLTGDNEIVTARI 548
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   636 CRRIGIfseneeVTDRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAE 715
Cdd:TIGR01524 549 CQEVGI------DANDFLLGADIEELSDEELARELRKYHIFARLTPMQKSRIIGLLKKAGHTVGFLGDGINDAPALRKAD 622
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   716 IGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWV 795
Cdd:TIGR01524 623 VGISVDTAADIAKEASDIILLEKSLMVLEEGVIEGRNTFGNILKYLKMTASSNFGNVFSVLVASAFIPFLPMLSLHLLIQ 702
                         810       820
                  ....*....|....*....|....*..
gi 36031132   796 NLVTDgLPATALGFNPPDLDIMDRPPR 822
Cdd:TIGR01524 703 NLLYD-FSQLTLPWDKMDREFLKKPHQ 728
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
23-813 2.78e-78

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 269.15  E-value: 2.78e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  23 GLTPDQVKRHLEKYGPNELPAEEGKSLWELVveqFEDLLVRI----LLLAACISFVLAWfeegeetvtafvEPFVILLIL 98
Cdd:cd02609   1 GLTTKEVEERQAEGKVNDQVEPVSRSVWQIV---RENVFTLFnlinFVIAVLLILVGSY------------SNLAFLGVI 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  99 IANAIVGVWQERNAENAIEALKEYEPEMGKVYRaDRKsVQRIKARDIVPGDIVEVAVGDKVPADIRILSikSTTLRVDQS 178
Cdd:cd02609  66 IVNTVIGIVQEIRAKRQLDKLSILNAPKVTVIR-DGQ-EVKIPPEELVLDDILILKPGEQIPADGEVVE--GGGLEVDES 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 179 ILTGESVSVIKHTDpvpdpravnqDKknmLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDefge 258
Cdd:cd02609 142 LLTGESDLIPKKAG----------DK---LLSGSFVVSGAAYARVTAVGAESYAAKLTLEAKKHKLINSELLNSIN---- 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 259 QLSKVISLICVAVWLINI--GHFndpVHGGSWFRGAIyyfkIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSL 336
Cdd:cd02609 205 KILKFTSFIIIPLGLLLFveALF---RRGGGWRQAVV----STVAALLGMIPEGLVLLTSVALAVGAIRLAKKKVLVQEL 277
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 337 PSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDkvdgdvcslnefsitgstyapegevlkndkpvragqydglvelati 416
Cdd:cd02609 278 YSIETLARVDVLCLDKTGTITEGKMKVERVEPLD---------------------------------------------- 311
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 417 calcndssldfnetkgvyEKVGEATETALTTLVEKMNVFNTEVRSLskverANACNSVIRQLMKKEftLEFSRDRKsmsv 496
Cdd:cd02609 312 ------------------EANEAEAAAALAAFVAASEDNNATMQAI-----RAAFFGNNRFEVTSI--IPFSSARK---- 362
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 497 YCSPAKSSRAAvgnkmFVKGAPEgVIDRCNYvrvgttrvpltgpvkEKIMSVIKEW-GTGRdtlRCLALAtRDTPPKREE 575
Cdd:cd02609 363 WSAVEFRDGGT-----WVLGAPE-VLLGDLP---------------SEVLSRVNELaAQGY---RVLLLA-RSAGALTHE 417
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 576 MVLDdsakfmeyemDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSENEEVTDRAYTG 655
Cdd:cd02609 418 QLPV----------GLEPLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAGLEGAESYIDASTLTT 487
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 656 REfddlplaEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVL 735
Cdd:cd02609 488 DE-------ELAEAVENYTVFGRVTPEQKRQLVQALQALGHTVAMTGDGVNDVLALKEADCSIAMASGSDATRQVAQVVL 560
                       730       740       750       760       770       780       790
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 36031132 736 ADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPD 813
Cdd:cd02609 561 LDSDFSALPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNK 638
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
1-800 6.49e-71

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 253.79  E-value: 6.49e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    1 MEAAHSksTEECLSYFGvSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVL-AWF- 78
Cdd:PRK15122  26 REAANS--LEETLANLN-THRQGLTEEDAAERLQRYGPNEVAHEKPPHALVQLLQAFNNPFIYVLMVLAAISFFTdYWLp 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   79 -EEGEETVTAFVepFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYR---ADRKSVQR-IKARDIVPGDIVEV 153
Cdd:PRK15122 103 lRRGEETDLTGV--IIILTMVLLSGLLRFWQEFRSNKAAEALKAMVRTTATVLRrghAGAEPVRReIPMRELVPGDIVHL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  154 AVGDKVPADIRIlsIKSTTLRVDQSILTGESVSV----------IKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAVGIV 223
Cdd:PRK15122 181 SAGDMIPADVRL--IESRDLFISQAVLTGEALPVekydtlgavaGKSADALADDEGSLLDLPNICFMGTNVVSGTATAVV 258
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  224 ATTGVSTEIGKIRDQMAATEqdktpLQQKLDEFGEQLSKVI---SLICV-AVWLINighfndPVHGGSWFRGAIYyfkiA 299
Cdd:PRK15122 259 VATGSRTYFGSLAKSIVGTR-----AQTAFDRGVNSVSWLLirfMLVMVpVVLLIN------GFTKGDWLEALLF----A 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  300 VALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQmsvckmfII--------DK 371
Cdd:PRK15122 324 LAVAVGLTPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDR-------IIlehhldvsGR 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  372 VDGDVCS---LNEFSITGStyapegevlKN--DKPVragqydglvelaticalcndssLDFNETKGVYEKVgeatetalt 446
Cdd:PRK15122 397 KDERVLQlawLNSFHQSGM---------KNlmDQAV----------------------VAFAEGNPEIVKP--------- 436
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  447 tlvekmnvfntevRSLSKVEranacnsvirqlmkkEFTLEFSRDRKSMSVycspakssRAAVGNKMFV-KGAPEGVIDRC 525
Cdd:PRK15122 437 -------------AGYRKVD---------------ELPFDFVRRRLSVVV--------EDAQGQHLLIcKGAVEEMLAVA 480
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  526 NYVRVGTTRVPLTGPVKEKIMSVIKEWGtgRDTLRCLALATRDTPPKREEMVL--DDsakfmeyEMDLTFVGVVGMLDPP 603
Cdd:PRK15122 481 THVRDGDTVRPLDEARRERLLALAEAYN--ADGFRVLLVATREIPGGESRAQYstAD-------ERDLVIRGFLTFLDPP 551
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  604 RKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIfsENEEVtdraYTGREFDDLPLAEQREACRRACCFARVEPSH 683
Cdd:PRK15122 552 KESAAPAIAALRENGVAVKVLTGDNPIVTAKICREVGL--EPGEP----LLGTEIEAMDDAALAREVEERTVFAKLTPLQ 625
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  684 KSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMkqfIRY 763
Cdd:PRK15122 626 KSRVLKALQANGHTVGFLGDGINDAPALRDADVGISVDSGADIAKESADIILLEKSLMVLEEGVIKGRETFGNI---IKY 702
                        810       820       830       840
                 ....*....|....*....|....*....|....*....|.
gi 36031132  764 L---ISSNVGEVVCIfLTAALGLP-EALIPVQLLWVNLVTD 800
Cdd:PRK15122 703 LnmtASSNFGNVFSV-LVASAFIPfLPMLAIHLLLQNLMYD 742
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
59-783 8.54e-52

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 194.59  E-value: 8.54e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  59 DLLVRI-LLLAACISFVLAWFEEGEETVTAFVepFVILLILIANAIvgvwQER---NAENAIEALKEYEPEMGKVYRADR 134
Cdd:COG2217 149 DVLVALgTLAAFLYSLYATLFGAGHVYFEAAA--MIIFLLLLGRYL----EARakgRARAAIRALLSLQPKTARVLRDGE 222
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 135 ksVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTtlrVDQSILTGESVSVIKHT-DPVpdpravnqdkknmlFSGTN 213
Cdd:COG2217 223 --EVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS---VDESMLTGESLPVEKTPgDEV--------------FAGTI 283
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 214 IAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQkldeFGEQLSKV-------ISLICVAVWLINIGHFNDpvhgg 286
Cdd:COG2217 284 NLDGSLRVRVTKVGSDTTLARIIRLVEEAQSSKAPIQR----LADRIARYfvpavlaIAALTFLVWLLFGGDFST----- 354
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 287 sWFRGAIyyfkiavalavaaipeglpAV-ITTC---LAL--------GTRRMAKKNAIVRSLPSVETLGCTSVICSDKTG 354
Cdd:COG2217 355 -ALYRAV-------------------AVlVIACpcaLGLatptaimvGTGRAARRGILIKGGEALERLAKVDTVVFDKTG 414
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 355 TLTTNQMSVckmfiidkvdGDVCSLNEFSitgstyapEGEVLkndkpvragqydglvelATICALcndssldfnetkgvy 434
Cdd:COG2217 415 TLTEGKPEV----------TDVVPLDGLD--------EDELL-----------------ALAAAL--------------- 444
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 435 ekvgeatetalttlvekmnvfntEVRS---LSKveranacnSVIRQLMKKEFTLEfsrdrksmsvycsPAKSSRAAVGnk 511
Cdd:COG2217 445 -----------------------EQGSehpLAR--------AIVAAAKERGLELP-------------EVEDFEAIPG-- 478
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 512 mfvKGApEGVIDRcNYVRVGTTR------VPLTGPVKEKIMSVIKEWGTgrdtlrCLALATrdtppkreemvlddsakfm 585
Cdd:COG2217 479 ---KGV-EATVDG-KRVLVGSPRlleeegIDLPEALEERAEELEAEGKT------VVYVAV------------------- 528
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 586 eyemDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIfsenEEVtdraytgrefddlplae 665
Cdd:COG2217 529 ----DGRLLGLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELGI----DEV----------------- 583
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 666 qreacrraccFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVA 745
Cdd:COG2217 584 ----------RAEVLPEDKAAAVRELQAQGKKVAMVGDGINDAPALAAADVGIAMGSGTDVAIEAADIVLMRDDLRGVPD 653
                       730       740       750       760
                ....*....|....*....|....*....|....*....|...
gi 36031132 746 AVEEGRAIYNNMKQ-----FIrYlissNvgeVVCIFLtAALGL 783
Cdd:COG2217 654 AIRLSRATMRIIRQnlfwaFG-Y----N---VIGIPL-AAGGL 687
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
69-790 1.56e-51

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 190.92  E-value: 1.56e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    69 ACISFVLAWFeegeetVTAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADrKSVQRIKARDIVPG 148
Cdd:TIGR01525   5 MALAAIAAYA------MGLVLEGALLLFLFLLGETLEERAKSRASDALSALLALAPSTARVLQGD-GSEEEVPVEELQVG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   149 DIVEVAVGDKVPADIRILSIKSTtlrVDQSILTGESVSVIKHT-DPVpdpravnqdkknmlFSGTNIAAGKAVGIVATTG 227
Cdd:TIGR01525  78 DIVIVRPGERIPVDGVVISGESE---VDESALTGESMPVEKKEgDEV--------------FAGTINGDGSLTIRVTKLG 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   228 VSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLInighfndPVHGGSWFRGAIYYFkiaVALAVAAI 307
Cdd:TIGR01525 141 EDSTLAQIVELVEEAQSSKAPIQRLADRIASYYVPAVLAIALLTFVV-------WLALGALWREALYRA---LTVLVVAC 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   308 PEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVckmfiidkvdgdvcslnefsitgs 387
Cdd:TIGR01525 211 PCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTV------------------------ 266
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   388 tyapegevlKNDKPVRAGQYDGLVELATicalcndssldfnetkgvyekvgeatetalttlvekmnvfNTEVRSLSKVER 467
Cdd:TIGR01525 267 ---------VDIEPLDDASEEELLALAA----------------------------------------ALEQSSSHPLAR 297
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   468 AnacnsVIRQLMKKEFTlefsrdrksmsvycSPAKSSRAAVGnkmfvKGApEGVIDRCNYVRVGTTRVPLTGPVKEKIMS 547
Cdd:TIGR01525 298 A-----IVRYAKERGLE--------------LPPEDVEEVPG-----KGV-EATVDGGREVRIGNPRFLGNRELAIEPIS 352
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   548 V----IKEWGTGRDTLRCLALatrdtppkreemvlddsakfmeyemDLTFVGVVGMLDPPRKEVTGSIQ-LCRDAGIRVI 622
Cdd:TIGR01525 353 AspdlLNEGESQGKTVVFVAV-------------------------DGELLGVIALRDQLRPEAKEAIAaLKRAGGIKLV 407
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   623 MITGDNKGTAIAICRRIGIfseNEEVtdraytgrefddlplaeqreacrraccFARVEPSHKSKIVEYLQSYDEITAMTG 702
Cdd:TIGR01525 408 MLTGDNRSAAEAVAAELGI---DDEV---------------------------HAELLPEDKLAIVKKLQEEGGPVAMVG 457
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   703 DGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGevvcIFLTAALG 782
Cdd:TIGR01525 458 DGINDAPALAAADVGIAMGSGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNLV----AIPLAAGG 533

                  ....*...
gi 36031132   783 LPEALIPV 790
Cdd:TIGR01525 534 LLPLWLAV 541
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
59-788 1.64e-48

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 183.18  E-value: 1.64e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  59 DLLVrilLLAACISFVLAWFEEGEETVTAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEmgKVYRADRKSVQ 138
Cdd:cd02079  62 DVLV---SLAAIGAFVASLLTPLLGGIGYFEEAAMLLFLFLLGRYLEERARSRARSALKALLSLAPE--TATVLEDGSTE 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 139 RIKARDIVPGDIVEVAVGDKVPADIRILSIKSTtlrVDQSILTGESVSVIKHT-DPVpdpravnqdkknmlFSGTnIAAG 217
Cdd:cd02079 137 EVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS---VDESSLTGESLPVEKGAgDTV--------------FAGT-INLN 198
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 218 KAVGIVAT-TGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLInighfndPVHGGSWFRGAIYYf 296
Cdd:cd02079 199 GPLTIEVTkTGEDTTLAKIIRLVEEAQSSKPPLQRLADRFARYFTPAVLVLAALVFLF-------WPLVGGPPSLALYR- 270
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 297 kiavalavaaipeGLPAVITTC---LAL--------GTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCk 365
Cdd:cd02079 271 -------------ALAVLVVACpcaLGLatptaivaGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVT- 336
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 366 mfiidkvdgDVCSLNEFSitgstyapEGEVLKndkpvragqydglvELATIcalcndssldfnetkgvyekvgeatetal 445
Cdd:cd02079 337 ---------EIEPLEGFS--------EDELLA--------------LAAAL----------------------------- 356
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 446 ttlvekmnvfntEVRSLSKVERAnacnsVIRQLMKKEFTLEFSRDRKSmsvycspakssraavgnkmfVKGapEGVIDRC 525
Cdd:cd02079 357 ------------EQHSEHPLARA-----IVEAAEEKGLPPLEVEDVEE--------------------IPG--KGISGEV 397
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 526 N--YVRVGTTRVPLTGPVKEKIMSVIKEwgtGRDTLrcLALATRDTPpkreemvlddsakfmeyemdltfVGVVGMLDPP 603
Cdd:cd02079 398 DgrEVLIGSLSFAEEEGLVEAADALSDA---GKTSA--VYVGRDGKL-----------------------VGLFALEDQL 449
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 604 RKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIfsenEEVtdraytgrefddlplaeqreacrraccFARVEPSH 683
Cdd:cd02079 450 RPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGI----DEV---------------------------HAGLLPED 498
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 684 KSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRY 763
Cdd:cd02079 499 KLAIVKALQAEGGPVAMVGDGINDAPALAQADVGIAMGSGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAW 578
                       730       740
                ....*....|....*....|....*
gi 36031132 764 LISSNvgeVVCIFLtAALGLPEALI 788
Cdd:cd02079 579 ALGYN---AIALPL-AALGLLTPWI 599
E1-E2_ATPase pfam00122
E1-E2 ATPase;
121-329 7.51e-46

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 162.74  E-value: 7.51e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   121 EYEPEMGKVYRADrkSVQRIKARDIVPGDIVEVAVGDKVPADIRILSiksTTLRVDQSILTGESVSVIKHtdpvpdprav 200
Cdd:pfam00122   1 SLLPPTATVLRDG--TEEEVPADELVPGDIVLLKPGERVPADGRIVE---GSASVDESLLTGESLPVEKK---------- 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   201 nqdKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIghfn 280
Cdd:pfam00122  66 ---KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWL---- 138
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 36031132   281 dpvhggSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKK 329
Cdd:pfam00122 139 ------FVGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
18-788 1.63e-44

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 174.86  E-value: 1.63e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132     18 VSETTGLTPDQVKRHLEKYGPNELpaeegkslwELVVEQFEDLLVR------ILLLAACisfVLAWFEEGEETVTAFvep 91
Cdd:TIGR01657  134 AGHSNGLTTGDIAQRKAKYGKNEI---------EIPVPSFLELLKEevlhpfYVFQVFS---VILWLLDEYYYYSLC--- 198
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132     92 fvILLILIANAIVGVWQERNAENAIEALKeYEPEMGKVYRADRKsvQRIKARDIVPGDIVEVAV--GDKVPADIRILSik 169
Cdd:TIGR01657  199 --IVFMSSTSISLSVYQIRKQMQRLRDMV-HKPQSVIVIRNGKW--VTIASDELVPGDIVSIPRpeEKTMPCDSVLLS-- 271
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    170 sTTLRVDQSILTGESVSVIK-----HTDPVPDPRAVNQDKKNMLFSGTNI-------AAGKAVGIVATTGVSTEIGK-IR 236
Cdd:TIGR01657  272 -GSCIVNESMLTGESVPVLKfpipdNGDDDEDLFLYETSKKHVLFGGTKIlqirpypGDTGCLAIVVRTGFSTSKGQlVR 350
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    237 DQMAATEQDKtplQQKLDEFGEQLSKVISLICVAVWLINIGhFNDPVHGGSWFRGAIyyfkiavALAVAAIPEGLPAVIT 316
Cdd:TIGR01657  351 SILYPKPRVF---KFYKDSFKFILFLAVLALIGFIYTIIEL-IKDGRPLGKIILRSL-------DIITIVVPPALPAELS 419
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    317 TCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVckmfiidkvdgdvcslnefsitgSTYAPEGEVL 396
Cdd:TIGR01657  420 IGINNSLARLKKKGIFCTSPFRINFAGKIDVCCFDKTGTLTEDGLDL-----------------------RGVQGLSGNQ 476
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    397 KNDKPVRAGQYDGLVELATICALCndSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRSLSKVERANACN--SV 474
Cdd:TIGR01657  477 EFLKIVTEDSSLKPSITHKALATC--HSLTKLEGKLVGDPLDKKMFEATGWTLEEDDESAEPTSILAVVRTDDPPQelSI 554
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    475 IRQlmkkeftLEFSRDRKSMSVYCSPAKSSRAavgnKMFVKGAPEGVIDRCNyvrvgttrvPLTGPVKEKimSVIKEWgt 554
Cdd:TIGR01657  555 IRR-------FQFSSALQRMSVIVSTNDERSP----DAFVKGAPETIQSLCS---------PETVPSDYQ--EVLKSY-- 610
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    555 GRDTLRCLALATRDTPPKREEMVLDDSAKfmEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIA 634
Cdd:TIGR01657  611 TREGYRVLALAYKELPKLTLQKAQDLSRD--AVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVH 688
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    635 ICRRIGI-FSENEEVTDRAYTGR---------------------EFDDLPLAEQRE----ACRRACC------------- 675
Cdd:TIGR01657  689 VARECGIvNPSNTLILAEAEPPEsgkpnqikfevidsipfastqVEIPYPLGQDSVedllASRYHLAmsgkafavlqahs 768
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    676 -------------FARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAktASEMVLADDNFST 742
Cdd:TIGR01657  769 pelllrllshttvFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASV--AAPFTSKLASISC 846
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 36031132    743 IVAAVEEGRA-------IYNNMKQ---------FIRYLISSNVGEVVCIFLTAALGLPEALI 788
Cdd:TIGR01657  847 VPNVIREGRCalvtsfqMFKYMALysliqfysvSILYLIGSNLGDGQFLTIDLLLIFPVALL 908
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
784-987 3.46e-44

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 157.79  E-value: 3.46e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   784 PEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFR------YMAIGGYVGaatvgaaawwFL 857
Cdd:pfam00689   1 PLPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRillqglLIAILTLLV----------FF 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   858 YAEDGPHVSYHQLThfmqctehnpefdgldcevfeapepMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSI 937
Cdd:pfam00689  71 LGLLGFGISESQNA-------------------------QTMAFNTLVLSQLFNALNARSLRRSLFKIGLFSNKLLLLAI 125
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 36031132   938 CLSMSLHFLILYVDPLPMIFKLRALDFTQWLMVLKISLPVIGLDELLKFI 987
Cdd:pfam00689 126 LLSLLLQLLIIYVPPLQAVFGTTPLSLEQWLIVLLLALVVLLVVELRKLL 175
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
36-830 2.32e-41

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 163.57  E-value: 2.32e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  36 YGPNELPAEEgKSLWELVVEQ-------FEdllvrilllaaCISfVLAWFEEGeetvtaFVE-PFVILLILIANAIVGVW 107
Cdd:cd07542  10 YGPNEIDVPL-KSILKLLFKEvlnpfyvFQ-----------LFS-VILWSSDD------YYYyAACIVIISVISIFLSLY 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 108 QERNAENAIEALKEYePEMGKVYRadRKSVQRIKARDIVPGDIVEVAVGDKV-PADIRILSiksTTLRVDQSILTGESVS 186
Cdd:cd07542  71 ETRKQSKRLREMVHF-TCPVRVIR--DGEWQTISSSELVPGDILVIPDNGTLlPCDAILLS---GSCIVNESMLTGESVP 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 187 VIK-----HTDPVPDPRAVNQD-KKNMLFSGTNI------AAGKAVGIVATTGVSTEIGK-IRDQMAAteqDKTPLQQKL 253
Cdd:cd07542 145 VTKtplpdESNDSLWSIYSIEDhSKHTLFCGTKViqtrayEGKPVLAVVVRTGFNTTKGQlVRSILYP---KPVDFKFYR 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 254 DEFgeqlSKVISLICVAvwLInighfndpvhggSWFRGAIYYFKIAVALAVA----------AIPEGLPAVITTCLALGT 323
Cdd:cd07542 222 DSM----KFILFLAIIA--LI------------GFIYTLIILILNGESLGEIiiraldiitiVVPPALPAALTVGIIYAQ 283
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 324 RRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSV-CKMFIIDKVDGDVCSLNEFSITGSTyapegevLKNDKPV 402
Cdd:cd07542 284 SRLKKKGIFCISPQRINICGKINLVCFDKTGTLTEDGLDLwGVRPVSGNNFGDLEVFSLDLDLDSS-------LPNGPLL 356
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 403 RAgqydglveLATICALcndSSLDfnetkgvYEKVGEATETalttlveKMnvfntevrslskVERANACNSVIRQLmkke 482
Cdd:cd07542 357 RA--------MATCHSL---TLID-------GELVGDPLDL-------KM------------FEFTGWSLEILRQF---- 395
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 483 ftlEFSRDRKSMSVYCS-PAKSSRAAvgnkmFVKGAPEGVIDRCNyvrvgttrvPLTGPvkEKIMSVIKEWGtgRDTLRC 561
Cdd:cd07542 396 ---PFSSALQRMSVIVKtPGDDSMMA-----FTKGAPEMIASLCK---------PETVP--SNFQEVLNEYT--KQGFRV 454
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 562 LALATR--DTPP------KREEMvlddsakfmeyEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAI 633
Cdd:cd07542 455 IALAYKalESKTwllqklSREEV-----------ESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAI 523
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 634 AICRRIGIFSENEEVtdraYTGR---EFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPA 710
Cdd:cd07542 524 SVARECGMISPSKKV----ILIEavkPEDDDSASLTWTLLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGA 599
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 711 LKKAEIGIAMGSgtAVAKTASEMVLADDNFSTIVAAVEEGRA-------------IYnNMKQFIR----YLISSNVGEvv 773
Cdd:cd07542 600 LKAADVGISLSE--AEASVAAPFTSKVPDISCVPTVIKEGRAalvtsfscfkymaLY-SLIQFISvlilYSINSNLGD-- 674
                       810       820       830       840       850
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 36031132 774 cifltaalglpealipVQLLWVNLVTDGLPATALGFNPPDLDIM-DRPPRSpkepLIS 830
Cdd:cd07542 675 ----------------FQFLFIDLVIITPIAVFMSRTGAYPKLSsKRPPAS----LVS 712
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
58-800 1.12e-40

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 158.64  E-value: 1.12e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    58 EDLLVRILLLAACisFVLAWFEEGeetvtafvepfVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADrkSV 137
Cdd:TIGR01512   1 VDLLMALAALGAV--AIGEYLEGA-----------LLLLLFSIGETLEEYASGRARRALKALMELAPDTARRLQGD--SL 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   138 QRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTtlrVDQSILTGESVSVIKHTDpvpdpravnqDKknmLFSGTnIAAG 217
Cdd:TIGR01512  66 EEVAVEELKVGDVVVVKPGERVPVDGEVLSGTSS---VDESALTGESVPVEKAPG----------DE---VFAGA-INLD 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   218 KAVGIVAT-TGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLInighFNDPVHGgsWFRGAIYYF 296
Cdd:TIGR01512 129 GVLTIEVTkLPADSTIAKIVNLVEEAQSRKAPTQRFIDRFARYYTPAVLAIALAAALV----PPLLGAG--PFLEWIYRA 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   297 kiaVALAVAAIPEGLpaVITTCLAL--GTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCkmfiidkvdg 374
Cdd:TIGR01512 203 ---LVLLVVASPCAL--VISAPAAYlsAISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVT---------- 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   375 DVCSLNEFSitgstyapEGEVLKndkpvragqydglvelatiCALCndssldfnetkgvyekvgeatetalttlvekmnv 454
Cdd:TIGR01512 268 DVHPADGHS--------ESEVLR-------------------LAAA---------------------------------- 286
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   455 fnTEVRSLSKVERAnacnsVIRQLMKKEFTLefsrdrksmsvycsPAKSSRAAVGnkmfvkgapEGVIDRCN--YVRVGT 532
Cdd:TIGR01512 287 --AEQGSTHPLARA-----IVDYARARELAP--------------PVEDVEEVPG---------EGVRAVVDggEVRIGN 336
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   533 TRVpltgpVKEKIMSVIKEWGTGRDTlrcLALATRDTppkreemvlddsakfmeyemdlTFVGVVGMLDPPRKEVTGSIQ 612
Cdd:TIGR01512 337 PRS-----LSEAVGASIAVPESAGKT---IVLVARDG----------------------TLLGYIALSDELRPDAAEAIA 386
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   613 LCRDAGI-RVIMITGDNKGTAIAICRRIGIfsenEEVtdraytgrefddlplaeqreacrraccFARVEPSHKSKIVEYL 691
Cdd:TIGR01512 387 ELKALGIkRLVMLTGDRRAVAEAVARELGI----DEV---------------------------HAELLPEDKLEIVKEL 435
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   692 QSYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQfirylissNVg 770
Cdd:TIGR01512 436 REKAGPVAMVGDGINDAPALAAADVGIAMGaSGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQ--------NV- 506
                         730       740       750
                  ....*....|....*....|....*....|
gi 36031132   771 eVVCIFLTAALGLPeALIPVQLLWVNLVTD 800
Cdd:TIGR01512 507 -VIALGIILVLILL-ALFGVLPLWLAVLGH 534
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
72-759 1.43e-38

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 152.43  E-value: 1.43e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    72 SFVLAWFEEGEETVTAFVEPFVILLILIanaiVGVWQERNAE----NAIEALKEYEPEMGKVYRADrKSVQRIKARDIVP 147
Cdd:TIGR01511  38 ALLANQVLTGLHVHTFFDASAMLITFIL----LGRWLEMLAKgrasDALSKLAKLQPSTATLLTKD-GSIEEVPVALLQP 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   148 GDIVEVAVGDKVPADIRILSIKSTtlrVDQSILTGESVSVIKHT-DPVpdpravnqdkknmlFSGTNIAAGKAVGIVATT 226
Cdd:TIGR01511 113 GDIVKVLPGEKIPVDGTVIEGESE---VDESLVTGESLPVPKKVgDPV--------------IAGTVNGTGSLVVRATAT 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   227 GVSTEIGKIRDQMAATEQDKTPLQQkldeFGEQLSK-------VISLICVAVWLInighfndpvhggswfrgAIYYFkia 299
Cdd:TIGR01511 176 GEDTTLAQIVRLVRQAQQSKAPIQR----LADKVAGyfvpvviAIALITFVIWLF-----------------ALEFA--- 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   300 VALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDVCsl 379
Cdd:TIGR01511 232 VTVLIIACPCALGLATPTVIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVTDVHVFGDRDRTEL-- 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   380 nefsitgstyapegevlkndkpvragqydglveLATICALCNDSSldfnetkgvyekvgeatetalttlvekmnvfntev 459
Cdd:TIGR01511 310 ---------------------------------LALAAALEAGSE----------------------------------- 321
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   460 RSLSKveranacnSVIRQLMKKEFTLEFSRDRKSMsvycsPAKSSRAAVGNKMFVKGapegvidRCNYVRVGTtrVPLTG 539
Cdd:TIGR01511 322 HPLAK--------AIVSYAKEKGITLVTVSDFKAI-----PGIGVEGTVEGTKIQLG-------NEKLLGENA--IKIDG 379
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   540 PVKEKIMSVIKEwgtgrdtlrclalatrdtppkreemvLDDSAkfmeyemdltfVGVVGMLDPPRKEVTGSIQLCRDAGI 619
Cdd:TIGR01511 380 KAGQGSTVVLVA--------------------------VNGEL-----------AGVFALEDQLRPEAKEVIQALKRRGI 422
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   620 RVIMITGDNKGTAIAICRRIGIfseneEVtdraytgrefddlplaeqreacrraccFARVEPSHKSKIVEYLQSYDEITA 699
Cdd:TIGR01511 423 EPVMLTGDNRKTAKAVAKELGI-----DV---------------------------RAEVLPDDKAALIKKLQEKGPVVA 470
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   700 MTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQ 759
Cdd:TIGR01511 471 MVGDGINDAPALAQADVGIAIGAGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKQ 530
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
92-759 7.56e-37

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 148.40  E-value: 7.56e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  92 FVILLILIanaivGVWQE----RNAENAIEALKEYEPEMGKVYRADrkSVQRIKARDIVPGDIVEVAVGDKVPADIRILS 167
Cdd:cd02094 107 VIITFILL-----GKYLEarakGKTSEAIKKLLGLQPKTARVIRDG--KEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVE 179
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 168 IKSTtlrVDQSILTGESVSVIKHT-DPVpdpravnqdkknmlFSGTnIAAGKAVGIVAT-TGVSTEIGKIRdQMAATEQ- 244
Cdd:cd02094 180 GESS---VDESMLTGESLPVEKKPgDKV--------------IGGT-INGNGSLLVRATrVGADTTLAQII-RLVEEAQg 240
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 245 DKTPLQQKLDefgeQLSKV-------ISLICVAVWLInIGHFNDPVHGgswFRGAIyyfkiavalavaaipeglpAV-IT 316
Cdd:cd02094 241 SKAPIQRLAD----RVSGVfvpvviaIAILTFLVWLL-LGPEPALTFA---LVAAV-------------------AVlVI 293
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 317 TC---LAL--------GTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDvcslnefsit 385
Cdd:cd02094 294 ACpcaLGLatptaimvGTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVTDVVPLPGDDED---------- 363
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 386 gstyapegEVLKndkpvragqydglvelatICAlcndsSLdfnetkgvyekvgeatetalttlvekmnvfntEVRS---L 462
Cdd:cd02094 364 --------ELLR------------------LAA-----SL--------------------------------EQGSehpL 380
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 463 SKveranacnSVIRQLMKKEFTLefsrdrksmsvycSPAKSSRAAVGnkmfvKGApEGVIDRCNyVRVGTTRVP--LTGP 540
Cdd:cd02094 381 AK--------AIVAAAKEKGLEL-------------PEVEDFEAIPG-----KGV-RGTVDGRR-VLVGNRRLMeeNGID 432
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 541 VKEKIMSVIKEWGTGRdTLRCLALATRdtppkreemvlddsakfmeyemdltFVGVVGMLDPPRKEVTGSIQLCRDAGIR 620
Cdd:cd02094 433 LSALEAEALALEEEGK-TVVLVAVDGE-------------------------LAGLIAVADPLKPDAAEAIEALKKMGIK 486
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 621 VIMITGDNKGTAIAICRRIGIfsenEEVtdraytgrefddlplaeqreacrraccFARVEPSHKSKIVEYLQSYDEITAM 700
Cdd:cd02094 487 VVMLTGDNRRTARAIAKELGI----DEV---------------------------IAEVLPEDKAEKVKKLQAQGKKVAM 535
                       650       660       670       680       690
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 36031132 701 TGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQ 759
Cdd:cd02094 536 VGDGINDAPALAQADVGIAIGSGTDVAIESADIVLMRGDLRGVVTAIDLSRATMRNIKQ 594
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
28-764 1.07e-36

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 149.28  E-value: 1.07e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  28 QVKRHLEKYGPNELpaeegkslwELVVEQFEDLLVRILLLAAcisFVLAWFEEGEETVTAFVEPFV-ILLILIANAIVGV 106
Cdd:cd02082   1 RVDQLLAYYGKNEI---------EINVPSFLTLMWREFKKPF---NFFQYFGVILWGIDEYVYYAItVVFMTTINSLSCI 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 107 WQERNAENAIEALKeYEPEMGKVYRADRKsVQRIKARDIVPGDIVEVAV-GDKVPADIRILSiksTTLRVDQSILTGESV 185
Cdd:cd02082  69 YIRGVMQKELKDAC-LNNTSVIVQRHGYQ-EITIASNMIVPGDIVLIKRrEVTLPCDCVLLE---GSCIVTEAMLTGESV 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 186 SVIKHT--DPVPDPRAVNQD--KKNMLFSGTNIAAGKA------VGIVATTGVSTEIGKIRdqmaateqdKTPLQQKLDE 255
Cdd:cd02082 144 PIGKCQipTDSHDDVLFKYEssKSHTLFQGTQVMQIIPpeddilKAIVVRTGFGTSKGQLI---------RAILYPKPFN 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 256 FGEQLSKVISLICVAVWLInIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS 335
Cdd:cd02082 215 KKFQQQAVKFTLLLATLAL-IGFLYTLIRLLDIELPPLFIAFEFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQD 293
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 336 LPSVETLGCTSVICSDKTGTLTTnqmsvckmfiiDKVDGDVCSLNEfsiTGSTYAPEGEVLKNDKpvragqydglVELAT 415
Cdd:cd02082 294 PNRISQAGRIQTLCFDKTGTLTE-----------DKLDLIGYQLKG---QNQTFDPIQCQDPNNI----------SIEHK 349
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 416 ICALCNDSSLDFNETkgvyekVGEATETALTTLVEKMNVFNTEVRSLSKVErANACNSVIRQLmkkeftlEFSRDRKSMS 495
Cdd:cd02082 350 LFAICHSLTKINGKL------LGDPLDVKMAEASTWDLDYDHEAKQHYSKS-GTKRFYIIQVF-------QFHSALQRMS 415
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 496 VYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVrvgttrvpltgPVKEK-IMSVIKEWGtgrdtLRCLALATRDTPPKRE 574
Cdd:cd02082 416 VVAKEVDMITKDFKHYAFIKGAPEKIQSLFSHV-----------PSDEKaQLSTLINEG-----YRVLALGYKELPQSEI 479
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 575 EMVLDDSAKFMEYEMDltFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFseneevtDRAYT 654
Cdd:cd02082 480 DAFLDLSREAQEANVQ--FLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQELEII-------NRKNP 550
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 655 GREFDDLPLAEQREA-CR-----RACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTavAK 728
Cdd:cd02082 551 TIIIHLLIPEIQKDNsTQwiliiHTNVFARTAPEQKQTIIRLLKESDYIVCMCGDGANDCGALKEADVGISLAEAD--AS 628
                       730       740       750
                ....*....|....*....|....*....|....*.
gi 36031132 729 TASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYL 764
Cdd:cd02082 629 FASPFTSKSTSISCVKRVILEGRVNLSTSVEIFKGY 664
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
52-769 6.02e-34

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 138.92  E-value: 6.02e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  52 LVVEQFEDLLVRILLLAACisFVLAWFEEGEETVTAFVEPFV----ILLILIA--NAIVGVWQE---------------- 109
Cdd:cd07551  16 LLLSKLGPQGVPWALFLLA--YLIGGYASAKEGIEATLRKKTlnvdLLMILAAigAAAIGYWAEgallififslshaled 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 110 ---RNAENAIEALKEYEPEMGKVYRADrKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTtlrVDQSILTGESVS 186
Cdd:cd07551  94 yamGRSKRAITALMQLAPETARRIQRD-GEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSSS---IDEASITGESIP 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 187 VIKHT-DPVpdpravnqdkknmlFSGT-NiaaGKAVGIVATTGVSTE--IGKIRdQMAATEQD-KTPLQQKLDEFGEQLS 261
Cdd:cd07551 170 VEKTPgDEV--------------FAGTiN---GSGALTVRVTKLSSDtvFAKIV-QLVEEAQSeKSPTQSFIERFERIYV 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 262 KVIsLICVAVwLINIGHFndpvhGGSW-FRGAIYyfkIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVE 340
Cdd:cd07551 232 KGV-LLAVLL-LLLLPPF-----LLGWtWADSFY---RAMVFLVVASPCALVASTPPATLSAIANAARQGVLFKGGVHLE 301
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 341 TLGCTSVICSDKTGTLTTNQMSVckmfiidkvdgdvcslnefsiTGSTYApegevlkndkpvragqydglvelaticalc 420
Cdd:cd07551 302 NLGSVKAIAFDKTGTLTEGKPRV---------------------TDVIPA------------------------------ 330
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 421 ndssldfnetkgvyEKVGEATETALTTLVEKMNvfntevrslskveranacNSVIRQLMKKEFTLEFSRDRKSMSVYCSP 500
Cdd:cd07551 331 --------------EGVDEEELLQVAAAAESQS------------------EHPLAQAIVRYAEERGIPRLPAIEVEAVT 378
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 501 AKSSRAAVGNKMFVKGAPEgvidrcnyvRVGTTRVPLTGPVKEKIMSvikewGTGRDTLrclalatrdtppkreeMVLDD 580
Cdd:cd07551 379 GKGVTATVDGQTYRIGKPG---------FFGEVGIPSEAAALAAELE-----SEGKTVV----------------YVARD 428
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 581 SakfmeyemdlTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIfseneevtDRAYTGrefdd 660
Cdd:cd07551 429 D----------QVVGLIALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI--------DEVVAN----- 485
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 661 lplaeqreacrraccfarVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNF 740
Cdd:cd07551 486 ------------------LLPEDKVAIIRELQQEYGTVAMVGDGINDAPALANADVGIAMGAGTDVALETADVVLMKDDL 547
                       730       740       750
                ....*....|....*....|....*....|....*.
gi 36031132 741 STIVAAVEEGRAIYNNMKQ-------FIRYLISSNV 769
Cdd:cd07551 548 SKLPYAIRLSRKMRRIIKQnlifalaVIALLIVANL 583
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
124-720 2.29e-32

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 135.59  E-value: 2.29e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 124 PEMGKVYRaDRKSVQrIKARDIVPGDIVEV---AVGDKVPADIRILSiksTTLRVDQSILTGESVSVIKHT-DPVPDPRA 199
Cdd:cd07543  85 PYTIQVYR-DGKWVP-ISSDELLPGDLVSIgrsAEDNLVPCDLLLLR---GSCIVNEAMLTGESVPLMKEPiEDRDPEDV 159
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 200 V---NQDKKNMLFSGTNIAA-------------GKAVGIVATTGVSTEIGK-IRDQMAATEQdKTplQQKLDEFGEQLSK 262
Cdd:cd07543 160 LdddGDDKLHVLFGGTKVVQhtppgkgglkppdGGCLAYVLRTGFETSQGKlLRTILFSTER-VT--ANNLETFIFILFL 236
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 263 VISLICVA--VWlinighfndpvHGGSwFRGAIYY--FKIAVALAVAAIPEGLP-----AVITTCLALgtrrmaKKNAIV 333
Cdd:cd07543 237 LVFAIAAAayVW-----------IEGT-KDGRSRYklFLECTLILTSVVPPELPmelslAVNTSLIAL------AKLYIF 298
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 334 RSLP-SVETLGCTSVICSDKTGTLTTNQMSVCkmfiidkvdgdvcslnefSITGstyapegevLKNDKPVRAGQYDGLVE 412
Cdd:cd07543 299 CTEPfRIPFAGKVDICCFDKTGTLTSDDLVVE------------------GVAG---------LNDGKEVIPVSSIEPVE 351
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 413 LATICALCNdsSLDFNETKGVyekVGEATETALTTlvekmNVFNTEVRSLSKVERANACNSVirQLMKKeftLEFSRDRK 492
Cdd:cd07543 352 TILVLASCH--SLVKLDDGKL---VGDPLEKATLE-----AVDWTLTKDEKVFPRSKKTKGL--KIIQR---FHFSSALK 416
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 493 SMSVYCSPAKSSRAAVGNKMFVKGAPEgvidrcnyvrvgTTRVPLTGPVKEKImSVIKEWGtgRDTLRCLALATRDTPPK 572
Cdd:cd07543 417 RMSVVASYKDPGSTDLKYIVAVKGAPE------------TLKSMLSDVPADYD-EVYKEYT--RQGSRVLALGYKELGHL 481
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 573 REEMVLDdsAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIfSENEEVT--- 649
Cdd:cd07543 482 TKQQARD--YKREDVESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACHVAKELGI-VDKPVLIlil 558
                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 36031132 650 DRAYTGREFDDLPLAEqreacrracCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAM 720
Cdd:cd07543 559 SEEGKSNEWKLIPHVK---------VFARVAPKQKEFIITTLKELGYVTLMCGDGTNDVGALKHAHVGVAL 620
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
93-807 3.53e-32

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 133.30  E-value: 3.53e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  93 VILLILIANAIVGVWQERnAENAIEALKEYEPEMGKVYRADRksVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTt 172
Cdd:cd07546  68 VLLLFLVGELLEGYAASR-ARSGVKALMALVPETALREENGE--RREVPADSLRPGDVIEVAPGGRLPADGELLSGFAS- 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 173 lrVDQSILTGESVSVIKHT-DPVpdpravnqdkknmlFSGTnIAAGKAVGIVATT--GVSTeIGKIRDQMAATEQDKTPL 249
Cdd:cd07546 144 --FDESALTGESIPVEKAAgDKV--------------FAGS-INVDGVLRIRVTSapGDNA-IDRILHLIEEAEERRAPI 205
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 250 QQKLDEFGEQLSKVISLICVAVWLInighfndP--VHGGSW----FRGaiyyfkiaVALAVAAIPEGL----PAVITTCL 319
Cdd:cd07546 206 ERFIDRFSRWYTPAIMAVALLVIVV-------PplLFGADWqtwiYRG--------LALLLIGCPCALvistPAAITSGL 270
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 320 ALGTRRmakkNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCkmfiidkvdgDVCSLNEFSitgstyapEGEVLKND 399
Cdd:cd07546 271 AAAARR----GALIKGGAALEQLGRVTTVAFDKTGTLTRGKPVVT----------DVVPLTGIS--------EAELLALA 328
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 400 KPVRAGQYDGLVElaticALcndssldfnetkgvyekVGEATETALTTLvekmnvfntevrslskveranacnsvirqlm 479
Cdd:cd07546 329 AAVEMGSSHPLAQ-----AI-----------------VARAQAAGLTIP------------------------------- 355
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 480 kkeftlefsrdrksmsvycsPAKSSRAAVGNKMfvkgapEGvidrcnyvRVGTTRVPLTGP--VKEKIMSVIKEwgtgrd 557
Cdd:cd07546 356 --------------------PAEEARALVGRGI------EG--------QVDGERVLIGAPkfAADRGTLEVQG------ 395
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 558 tlrclALATRDTPPKREEMVLDDSAkfmeyemdltFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICR 637
Cdd:cd07546 396 -----RIAALEQAGKTVVVVLANGR----------VLGLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAA 460
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 638 RIGIfseneevtdraytgrEFDdlplaeqreacrraccfARVEPSHKSKIVEYLQSYDEiTAMTGDGVNDAPALKKAEIG 717
Cdd:cd07546 461 ELGL---------------DFR-----------------AGLLPEDKVKAVRELAQHGP-VAMVGDGINDAPAMKAASIG 507
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 718 IAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQfirylissNVgevvciflTAALGLPEALIPVQL----- 792
Cdd:cd07546 508 IAMGSGTDVALETADAALTHNRLGGVAAMIELSRATLANIRQ--------NI--------TIALGLKAVFLVTTLlgitg 571
                       730
                ....*....|....*
gi 36031132 793 LWVNLVTDGlPATAL 807
Cdd:cd07546 572 LWLAVLADT-GATVL 585
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
92-787 7.14e-30

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 126.24  E-value: 7.14e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  92 FVILLILIANAIVgVWQERNAENAIEALKEYEPEMGKVYRADRksVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKST 171
Cdd:cd07550  68 TIAFLLELGELLE-DYTARKSEKALLDLLSPQERTVWVERDGV--EVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 172 tlrVDQSILTGESVSVikhtdpvpdPRAVNQdkknMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQ 251
Cdd:cd07550 145 ---IDQASLTGESLPV---------EKREGD----LVFASTVVEEGQLVIRAERVGRETRAARIAELIEQSPSLKARIQN 208
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 252 KLDEFGEQLSKVISLICVAVWLINighfndpvhgGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTClalgtrrmAKKNA 331
Cdd:cd07550 209 YAERLADRLVPPTLGLAGLVYALT----------GDISRAAAVLLVDFSCGIRLSTPVAVLSALNHA--------ARHGI 270
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 332 IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMfiidkvdgdVCSLNEFSitgstyapEGEVLKndkpvragqYDGLV 411
Cdd:cd07550 271 LVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAI---------ITFDGRLS--------EEDLLY---------LAASA 324
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 412 ElaticalcndssldfnetKGVYEKVGEAtetalttLVEKMNVFNTEVRSLSKVEranacnsvirqlmkkeftlefsrdr 491
Cdd:cd07550 325 E------------------EHFPHPVARA-------IVREAEERGIEHPEHEEVE------------------------- 354
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 492 ksmsvYcspakssRAAVGNKMFVKGAPegvidrcnyVRVGTTR------VPLTGPVKEKIMSVIKEWgtgrDTLRCLALA 565
Cdd:cd07550 355 -----Y-------IVGHGIASTVDGKR---------IRVGSRHfmeeeeIILIPEVDELIEDLHAEG----KSLLYVAID 409
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 566 TRdtppkreemvlddsakfmeyemdltFVGVVGMLDPPRKEVTGSI-QLCRDAGIRVIMITGDNKGTAIAICRRIGIfse 644
Cdd:cd07550 410 GR-------------------------LIGVIGLSDPLRPEAAEVIaRLRALGGKRIIMLTGDHEQRARALAEQLGI--- 461
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 645 neevtdraytgrefddlplaeqreacrrACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGT 724
Cdd:cd07550 462 ----------------------------DRYHAEALPEDKAEIVEKLQAEGRTVAFVGDGINDSPALSYADVGISMRGGT 513
                       650       660       670       680       690       700
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 36031132 725 AVAKTASEMVLADDNfstiVAAVEEGRAIYNNMKQFIRYLISSNVG-EVVCIFLTAALGLPEAL 787
Cdd:cd07550 514 DIARETADVVLLEDD----LRGLAEAIELARETMALIKRNIALVVGpNTAVLAGGVFGLLSPIL 573
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
93-781 1.31e-29

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 125.61  E-value: 1.31e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  93 VILLILIANAIVGVWQERnAENAIEALKEYEPEMGKVYRADRKSVqrIKARDIVPGDIVEVAVGDKVPADIRILSIKSTt 172
Cdd:cd07545  65 VVFLFAISEALEAYSMDR-ARRSIRSLMDIAPKTALVRRDGQERE--VPVAEVAVGDRMIVRPGERIAMDGIIVRGESS- 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 173 lrVDQSILTGESVSVIKhtdpvpdpravnqDKKNMLFSGTNIAAGkAVGIVATTGVS-TEIGKIRDQMAATEQDKTPLQQ 251
Cdd:cd07545 141 --VNQAAITGESLPVEK-------------GVGDEVFAGTLNGEG-ALEVRVTKPAEdSTIARIIHLVEEAQAERAPTQA 204
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 252 KLDEFGEQLSKVISLICVAVWLInighfndP--VHGGSWFrGAIYyfkIAVALAVAAIPEGLpaVITTCL----ALGTrr 325
Cdd:cd07545 205 FVDRFARYYTPVVMAIAALVAIV-------PplFFGGAWF-TWIY---RGLALLVVACPCAL--VISTPVsivsAIGN-- 269
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNqmsvckmfiidkvdgdvcslnefsitgstyapegevlkndKPVRAG 405
Cdd:cd07545 270 AARKGVLIKGGVYLEELGRLKTVAFDKTGTLTKG----------------------------------------KPVVTD 309
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 406 qydglvelaticalcndssldfnetkgvYEKVGEATETALTTLVEkmnvfNTEVRSLSKVERAnacnsvirqlmkkefTL 485
Cdd:cd07545 310 ----------------------------VVVLGGQTEKELLAIAA-----ALEYRSEHPLASA---------------IV 341
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 486 EFSRDRksmSVYCSPAKSSRAAVGnkmfvKGApEGVIDRcNYVRVGTTRVpltgpVKEKIMSVIKEWGTGRDTLRCLAla 565
Cdd:cd07545 342 KKAEQR---GLTLSAVEEFTALTG-----RGV-RGVVNG-TTYYIGSPRL-----FEELNLSESPALEAKLDALQNQG-- 404
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 566 trdtppKREEMVLDDSakfmeyemdlTFVGVVGMLDPPRKEVTGSIQLCRDAGI-RVIMITGDNKGTAIAICRRIGIfse 644
Cdd:cd07545 405 ------KTVMILGDGE----------RILGVIAVADQVRPSSRNAIAALHQLGIkQTVMLTGDNPQTAQAIAAQVGV--- 465
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 645 neevtdraytgrefddlplAEQReacrraccfARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGS-G 723
Cdd:cd07545 466 -------------------SDIR---------AELLPQDKLDAIEALQAEGGRVAMVGDGVNDAPALAAADVGIAMGAaG 517
                       650       660       670       680       690
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 36031132 724 TAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVgevvcIFLTAAL 781
Cdd:cd07545 518 TDTALETADIALMGDDLRKLPFAVRLSRKTLAIIKQNIAFALGIKL-----IALLLVI 570
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
418-528 1.95e-27

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 106.53  E-value: 1.95e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   418 ALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMnvfntevrslskveraNACNSVIRQLMKKEFTLEFSRDRKSMSVY 497
Cdd:pfam13246   1 ALCNSAAFDENEEKGKWEIVGDPTESALLVFAEKM----------------GIDVEELRKDYPRVAEIPFNSDRKRMSTV 64
                          90       100       110
                  ....*....|....*....|....*....|.
gi 36031132   498 CSPAKSSRaavgNKMFVKGAPEGVIDRCNYV 528
Cdd:pfam13246  65 HKLPDDGK----YRLFVKGAPEIILDRCTTI 91
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
128-728 2.83e-27

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 119.20  E-value: 2.83e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 128 KVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKS---------------TTLRVDQSILT----------G 182
Cdd:cd02073  84 PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSEpdglcyvetanldgeTNLKIRQALPEtalllseedlA 163
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 183 ESVSVIKHTDPVPD------------PRAVNQDKKNMLFSGTNIA-AGKAVGIVATTGVSTeigKIRDQMAATEQDKTPL 249
Cdd:cd02073 164 RFSGEIECEQPNNDlytfngtlelngGRELPLSPDNLLLRGCTLRnTEWVYGVVVYTGHET---KLMLNSGGTPLKRSSI 240
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 250 QQKLDE-----FGEQLSK-VISLICVAVWLINIGHFN---DPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLA 320
Cdd:cd02073 241 EKKMNRfiiaiFCILIVMcLISAIGKGIWLSKHGRDLwylLPKEERSPALEFFFDFLTFIILYNNLIPISLYVTIEVVKF 320
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 321 LGTRRM--------AKKN--AIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKmfiidkvdgdvCSLNEFSitgstya 390
Cdd:cd02073 321 LQSFFInwdldmydEETDtpAEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKK-----------CSINGVD------- 382
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 391 pegevlkndkpvragqYDGLVELAticaLCNDSSLDFNETKGVYEKVGEA-TETALTTLVEKMN-VFntevrslskVERA 468
Cdd:cd02073 383 ----------------YGFFLALA----LCHTVVPEKDDHPGQLVYQASSpDEAALVEAARDLGfVF---------LSRT 433
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 469 NacNSVIRQLMK--KEF----TLEFSRDRKSMSVYCspakssRAAVGN-KMFVKGAPEGVIDRCnyvrvgttrVPLTGPV 541
Cdd:cd02073 434 P--DTVTINALGeeEEYeilhILEFNSDRKRMSVIV------RDPDGRiLLYCKGADSVIFERL---------SPSSLEL 496
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 542 KEKIMSVIKEWGTgrDTLRCLALATRDTPPK------------------REEMvLDDSAKFMEYEMDLtfVGVVGMLDPP 603
Cdd:cd02073 497 VEKTQEHLEDFAS--EGLRTLCLAYREISEEeyeewnekydeastalqnREEL-LDEVAEEIEKDLIL--LGATAIEDKL 571
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 604 RKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSENeeVTDRAY--TGrefDDLPLAEQ-------REACRRA- 673
Cdd:cd02073 572 QDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCRLLSED--MENLALviDG---KTLTYALDpelerlfLELALKCk 646
                       650       660       670       680       690       700
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 36031132 674 ---CCfaRVEPSHKSKIVEYLQSY-DEITAMTGDGVNDAPALKKAEIGI----------AMGSGTAVAK 728
Cdd:cd02073 647 aviCC--RVSPLQKALVVKLVKKSkKAVTLAIGDGANDVSMIQEAHVGVgisgqegmqaARASDYAIAQ 713
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
84-759 3.45e-27

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 118.18  E-value: 3.45e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  84 TVTAFVEPF---VILLILIAnaIVGVWQERN----AENAIEALKEYEPEmgKVYRADRKSVQRIKARDIVPGDIVEVAVG 156
Cdd:cd07552  85 YFGEHGMDFfweLATLIVIM--LLGHWIEMKavmgAGDALKKLAELLPK--TAHLVTDGSIEDVPVSELKVGDVVLVRAG 160
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 157 DKVPADIRILSIKSttlRVDQSILTGESvsvikhtdpvpdpRAVNQDKKNMLFSGTnIAAGKAVGI-VATTGVSTEIGKI 235
Cdd:cd07552 161 EKIPADGTILEGES---SVNESMVTGES-------------KPVEKKPGDEVIGGS-VNGNGTLEVkVTKTGEDSYLSQV 223
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 236 RDQMAATEQDKTPLQQKLDEFGEQL---SKVISLICVAVWLInIGHFNDPVhggswfrgaiyyfKIAVALAVAAIPEGLP 312
Cdd:cd07552 224 MELVAQAQASKSRAENLADKVAGWLfyiALGVGIIAFIIWLI-LGDLAFAL-------------ERAVTVLVIACPHALG 289
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 313 AVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCkmfiidkvdgDVCSLNEFSitgstyapE 392
Cdd:cd07552 290 LAIPLVVARSTSIAAKNGLLIRNREALERARDIDVVLFDKTGTLTEGKFGVT----------DVITFDEYD--------E 351
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 393 GEVLKndkpvragqydglvelaTICALCNDSsldfnetkgvyekvgeatetalttlvekmnvfnTEVRSLSKVERANacn 472
Cdd:cd07552 352 DEILS-----------------LAAALEAGS---------------------------------EHPLAQAIVSAAK--- 378
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 473 svirqlmKKEFTLEFSRDRKSMsvycsPAKSSRAAVGNKmFVKGAPEGVIDRCNyVRVGTTRVPLTGPVKEKIMSVIKEw 552
Cdd:cd07552 379 -------EKGIRPVEVENFENI-----PGVGVEGTVNGK-RYQVVSPKYLKELG-LKYDEELVKRLAQQGNTVSFLIQD- 443
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 553 gtgRDTLRCLALAtrdtppkreemvlddsakfmeyemdltfvgvvgmlDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTA 632
Cdd:cd07552 444 ---GEVIGAIALG-----------------------------------DEIKPESKEAIRALKAQGITPVMLTGDNEEVA 485
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 633 IAICRRIGIfsenEEVtdraytgrefddlplaeqreacrraccFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALK 712
Cdd:cd07552 486 QAVAEELGI----DEY---------------------------FAEVLPEDKAKKVKELQAEGKKVAMVGDGVNDAPALA 534
                       650       660       670       680
                ....*....|....*....|....*....|....*....|....*..
gi 36031132 713 KAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQ 759
Cdd:cd07552 535 QADVGIAIGAGTDVAIESADVVLVKSDPRDIVDFLELAKATYRKMKQ 581
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
93-807 2.33e-24

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 109.70  E-value: 2.33e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   93 VILLILIANAIVGvWQERNAENAIEALKEYEPEMGKVYRADRKsvQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTt 172
Cdd:PRK11033 212 VLLLFLIGERLEG-YAASRARRGVSALMALVPETATRLRDGER--EEVAIADLRPGDVIEVAAGGRLPADGKLLSPFAS- 287
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  173 lrVDQSILTGESVSVIKHTdpvpdpravnqdkknmlfsGTNIAAGK-AVGIVATTGVSTE-----IGKIRDQMAATEQDK 246
Cdd:PRK11033 288 --FDESALTGESIPVERAT-------------------GEKVPAGAtSVDRLVTLEVLSEpgasaIDRILHLIEEAEERR 346
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  247 TPLQQKLDEFGEQLSKVISLICVAVWLInighfndP--VHGGSWfRGAIYyfkiavalavaaipEGL------------- 311
Cdd:PRK11033 347 APIERFIDRFSRIYTPAIMLVALLVILV-------PplLFAAPW-QEWIY--------------RGLtllligcpcalvi 404
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  312 --PAVITTCLALGTRRMA--KKNAIVRSLPSVETlgctsvICSDKTGTLTtnqmsvckmfiidkvdgdvcslnefsitgs 387
Cdd:PRK11033 405 stPAAITSGLAAAARRGAliKGGAALEQLGRVTT------VAFDKTGTLT------------------------------ 448
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  388 tyapEGevlkndKPvragQYDGLVELATIcalcndssldfnetkgvyekvgeaTETALTTLVEKMNVFNTEVRSLSKVER 467
Cdd:PRK11033 449 ----EG------KP----QVTDIHPATGI------------------------SESELLALAAAVEQGSTHPLAQAIVRE 490
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  468 ANAcnsviRQLMKKEftlefsrdrksmsvycspAKSSRAAVGnkmfvKGApEGVIDRCNYVRVGTTRVPltgPVKEKIMS 547
Cdd:PRK11033 491 AQV-----RGLAIPE------------------AESQRALAG-----SGI-EGQVNGERVLICAPGKLP---PLADAFAG 538
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  548 VIKEWGTGRDTLrclalatrdtppkreEMVLDDSakfmeyemdlTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGD 627
Cdd:PRK11033 539 QINELESAGKTV---------------VLVLRND----------DVLGLIALQDTLRADARQAISELKALGIKGVMLTGD 593
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  628 NKGTAIAICRRIGIfseneevtdraytgrEFDdlplaeqreacrraccfARVEPSHKSKIVEYLQSyDEITAMTGDGVND 707
Cdd:PRK11033 594 NPRAAAAIAGELGI---------------DFR-----------------AGLLPEDKVKAVTELNQ-HAPLAMVGDGIND 640
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  708 APALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIrylissnvgevvciflTAALGLPEAL 787
Cdd:PRK11033 641 APAMKAASIGIAMGSGTDVALETADAALTHNRLRGLAQMIELSRATHANIRQNI----------------TIALGLKAIF 704
                        730       740
                 ....*....|....*....|....*.
gi 36031132  788 IPVQL-----LWVNLVTD-GlpATAL 807
Cdd:PRK11033 705 LVTTLlgitgLWLAVLADsG--ATAL 728
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
52-753 2.78e-23

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 106.19  E-value: 2.78e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  52 LVVEqfedlLVRILLLAACIsFVLAWFEEGEETVTAFVEPFVILLILIANAIVGVWQERNAENAiEALKEYEPE-MGKVY 130
Cdd:cd02078  28 FVVE-----IGSIITTVLTF-FPLLFSGGGPAGFNLAVSLWLWFTVLFANFAEAIAEGRGKAQA-DSLRKTKTEtQAKRL 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 131 RADrKSVQRIKARDIVPGDIVEVAVGDKVPADIRILS-IKSttlrVDQSILTGESVSVIKhtDPVPDPRAVNqdkknmlf 209
Cdd:cd02078 101 RND-GKIEKVPATDLKKGDIVLVEAGDIIPADGEVIEgVAS----VDESAITGESAPVIR--ESGGDRSSVT-------- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 210 SGTNIAAGKA-VGIVATTGvSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLInighfndpvhggsw 288
Cdd:cd02078 166 GGTKVLSDRIkVRITANPG-ETFLDRMIALVEGASRQKTPNEIALTILLVGLTLIFLIVVATLPPF-------------- 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 289 frgAIYYfkiavalavaaipeGLPAVITTCLAL-------------------GTRRMAKKNAIVRSLPSVETLGCTSVIC 349
Cdd:cd02078 231 ---AEYS--------------GAPVSVTVLVALlvclipttiggllsaigiaGMDRLLRFNVIAKSGRAVEAAGDVDTLL 293
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 350 SDKTGTLTT-NQMSVcKMFIIDKVDgdvcslnefsitgstyapegevlknDKpvragqydglvELATICALcndSSLdFN 428
Cdd:cd02078 294 LDKTGTITLgNRQAT-EFIPVGGVD-------------------------EK-----------ELADAAQL---ASL-AD 332
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 429 ETKgvyekvgEATetALTTLVEKMNVFNTEVrslskveranacnsvirQLMKKEFtLEFSRDRKsMSVYCSPakssraav 508
Cdd:cd02078 333 ETP-------EGR--SIVILAKQLGGTERDL-----------------DLSGAEF-IPFSAETR-MSGVDLP-------- 376
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 509 GNKMFVKGAPEGVIdrcNYVRVGTTRVPltGPVKEKIMSVIKEWGTgrdtlrclALAtrdtppkreemVLDDSakfmeye 588
Cdd:cd02078 377 DGTEIRKGAVDAIR---KYVRSLGGSIP--EELEAIVEEISKQGGT--------PLV-----------VAEDD------- 425
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 589 mdlTFVGVVGMLD---PPRKEvtgSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIfseneevtdraytgrefDDLplae 665
Cdd:cd02078 426 ---RVLGVIYLKDiikPGIKE---RFAELRKMGIKTVMITGDNPLTAAAIAAEAGV-----------------DDF---- 478
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 666 qreacrraccFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVA 745
Cdd:cd02078 479 ----------LAEAKPEDKLELIRKEQAKGKLVAMTGDGTNDAPALAQADVGVAMNSGTQAAKEAGNMVDLDSDPTKLIE 548

                ....*...
gi 36031132 746 AVEEGRAI 753
Cdd:cd02078 549 VVEIGKQL 556
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
92-776 9.91e-22

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 101.32  E-value: 9.91e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   92 FVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKST 171
Cdd:PRK14010  70 IILLLTLVFANFSEALAEGRGKAQANALRQTQTEMKARRIKQDGSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKGLAT 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  172 tlrVDQSILTGESVSVIKHTdpvpdpravNQDKKNMLfSGTNIAAG-KAVGIVATTGVSTeIGKIRDQMAATEQDKTPLQ 250
Cdd:PRK14010 150 ---VDESAITGESAPVIKES---------GGDFDNVI-GGTSVASDwLEVEITSEPGHSF-LDKMIGLVEGATRKKTPNE 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  251 QKLDEFGEQLSKVISLICVAVW-LINIGHFNDPVhggswfrgaiyyfKIAVALAVAAIPEGLPAVITTCLALGTRRMAKK 329
Cdd:PRK14010 216 IALFTLLMTLTIIFLVVILTMYpLAKFLNFNLSI-------------AMLIALAVCLIPTTIGGLLSAIGIAGMDRVTQF 282
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  330 NAIVRSLPSVETLGCTSVICSDKTGTLT-TNQMSvckmfiidkvdgdvcslNEFSitgstyapegevlkndkPVRAGQYD 408
Cdd:PRK14010 283 NILAKSGRSVETCGDVNVLILDKTGTITyGNRMA-----------------DAFI-----------------PVKSSSFE 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  409 GLVELATICALCNDSSldfnetkgvyekvgeatetalttlvekmnvfntEVRSLSKVERANAcnsvirqlmkkeftLEFS 488
Cdd:PRK14010 329 RLVKAAYESSIADDTP---------------------------------EGRSIVKLAYKQH--------------IDLP 361
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  489 RDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRcnyVRVGTTRVPltGPVKEKIMSVIKEWGTgrdtlrclalatrd 568
Cdd:PRK14010 362 QEVGEYIPFTAETRMSGVKFTTREVYKGAPNSMVKR---VKEAGGHIP--VDLDALVKGVSKKGGT-------------- 422
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  569 tppkrEEMVLDDSakfmeyemdlTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIfseneev 648
Cdd:PRK14010 423 -----PLVVLEDN----------EILGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGV------- 480
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  649 tDRAytgrefddlplaeqreacrraccFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAK 728
Cdd:PRK14010 481 -DRF-----------------------VAECKPEDKINVIREEQAKGHIVAMTGDGTNDAPALAEANVGLAMNSGTMSAK 536
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*...
gi 36031132  729 TASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIF 776
Cdd:PRK14010 537 EAANLIDLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIANDIAKYFAIL 584
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
4-71 2.46e-21

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 88.39  E-value: 2.46e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 36031132     4 AHSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACI 71
Cdd:pfam00690   1 WHALSVEEVLKKLGTDLEKGLTEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
copA PRK10671
copper-exporting P-type ATPase CopA;
601-759 3.25e-21

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 99.82  E-value: 3.25e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  601 DPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIfsenEEVtdraytgrefddlplaeqreacrraccFARVE 680
Cdd:PRK10671 649 DPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGI----DEV---------------------------IAGVL 697
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 36031132  681 PSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQ 759
Cdd:PRK10671 698 PDGKAEAIKRLQSQGRQVAMVGDGINDAPALAQADVGIAMGGGSDVAIETAAITLMRHSLMGVADALAISRATLRNMKQ 776
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
110-788 1.91e-20

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 96.62  E-value: 1.91e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 110 RNAENAIEALKEYEPEMGKVYRADRksVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTtlrVDQSILTGESVSVIK 189
Cdd:cd07544  95 RRASRELTALLDRAPRIAHRLVGGQ--LEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTAT---LDESSLTGESKPVSK 169
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 190 HtdpvpdpravnqdKKNMLFSGTnIAAGKAVGIVATTGVS-TEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLIC 268
Cdd:cd07544 170 R-------------PGDRVMSGA-VNGDSALTMVATKLAAdSQYAGIVRLVKEAQANPAPFVRLADRYAVPFTLLALAIA 235
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 269 VAVWLINighfNDPVhggswfRGAiyyfkiavALAVAAIPegLPAVITTCLAL--GTRRMAKKNAIVRSLPSVETLGCTS 346
Cdd:cd07544 236 GVAWAVS----GDPV------RFA--------AVLVVATP--CPLILAAPVAIvsGMSRSSRRGILVKDGGVLEKLARAK 295
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 347 VICSDKTGTLTTNQMSVCKMFIIDKVDGDvcslnefsitgstyapegEVLKndkpvragqydglveLAticalcndSSLD 426
Cdd:cd07544 296 TVAFDKTGTLTYGQPKVVDVVPAPGVDAD------------------EVLR---------------LA--------ASVE 334
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 427 FNETKGVYEKVGEATETALTTLVEKMNVfnTEVrslskveranacnsvirqlmkkeftlefsrdrksmsvycsPAKSSRA 506
Cdd:cd07544 335 QYSSHVLARAIVAAARERELQLSAVTEL--TEV----------------------------------------PGAGVTG 372
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 507 AVGNKMfvkgapegvidrcnyVRVGttrvpltgpvKEKIMSVIKEWGtgrdtlrclalatrdtpPKREEMVLDDSAKFMe 586
Cdd:cd07544 373 TVDGHE---------------VKVG----------KLKFVLARGAWA-----------------PDIRNRPLGGTAVYV- 409
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 587 yEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGI-RVIMITGDNKGTAIAICRRIGIfseneevtdraytgrefDDlplae 665
Cdd:cd07544 410 -SVDGKYAGAITLRDEVRPEAKETLAHLRKAGVeRLVMLTGDRRSVAEYIASEVGI-----------------DE----- 466
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 666 qreacrracCFARVEPSHKSKIVEYlQSYDEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKTASEMVLADDNFSTIV 744
Cdd:cd07544 467 ---------VRAELLPEDKLAAVKE-APKAGPTIMVGDGVNDAPALAAADVGIAMGArGSTAASEAADVVILVDDLDRVV 536
                       650       660       670       680
                ....*....|....*....|....*....|....*....|....*.
gi 36031132 745 AAVeegrAIYNNMKQFIryLISSNVGEVVCI--FLTAALGLPEALI 788
Cdd:cd07544 537 DAV----AIARRTRRIA--LQSVLIGMALSIigMLIAAFGLIPPVA 576
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
5-75 6.80e-19

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 81.86  E-value: 6.80e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 36031132      5 HSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVL 75
Cdd:smart00831   5 HALSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
66-751 4.81e-18

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 89.17  E-value: 4.81e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    66 LLAACISFVLAWFEEGEETVTAFVEPFVILL---ILIANAIVGVWQERNAENAiEALKEYEPEMGKVYRADRKSVQRIKA 142
Cdd:TIGR01497  43 LLTTCITIAPASFGMPGNNLALFNAIITGILfitVLFANFAEAVAEGRGKAQA-DSLKGTKKTTFAKLLRDDGAIDKVPA 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   143 RDIVPGDIVEVAVGDKVPADIRILSIKSTtlrVDQSILTGESVSVIKhtDPVPDPRAVNqdkknmlfSGTNIAAGKAVGI 222
Cdd:TIGR01497 122 DQLKKGDIVLVEAGDVIPCDGEVIEGVAS---VDESAITGESAPVIK--ESGGDFASVT--------GGTRILSDWLVVE 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   223 VATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLInighfndpvhggSWFRGAIYYFKIAVAL 302
Cdd:TIGR01497 189 CTANPGETFLDRMIALVEGAQRRKTPNEIALTILLIALTLVFLLVTATLWPF------------AAYGGNAISVTVLVAL 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   303 AVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQmSVCKMFIidkvdgdvcslnef 382
Cdd:TIGR01497 257 LVCLIPTTIGGLLSAIGIAGMDRVLGFNVIATSGRAVEACGDVDTLLLDKTGTITLGN-RLASEFI-------------- 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   383 sitgstyapegevlkndkPVRAGQYDGLVELATICALCNDSSldfnETKGVYEkvgeatetalttLVEKMNVFNTEVRSL 462
Cdd:TIGR01497 322 ------------------PAQGVDEKTLADAAQLASLADDTP----EGKSIVI------------LAKQLGIREDDVQSL 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   463 SKveranacnsvirqlmkkEFtLEFSrdrksmsvycspAKSSRAAV---GNKMFVKGApEGVIDRcnYVRVGTTRVPLTg 539
Cdd:TIGR01497 368 HA-----------------TF-VEFT------------AQTRMSGInldNGRMIRKGA-VDAIKR--HVEANGGHIPTD- 413
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   540 pVKEKIMSVIKEWGTgrdtlrclALAtrdtppkreemVLDDSAKFmeyemdltfvGVVGMLDPPRKEVTGSIQLCRDAGI 619
Cdd:TIGR01497 414 -LDQAVDQVARQGGT--------PLV-----------VCEDNRIY----------GVIYLKDIVKGGIKERFAQLRKMGI 463
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   620 RVIMITGDNKGTAIAICRRIGIfseneevtdraytgrefDDLplaeqreacrraccFARVEPSHKSKIVEYLQSYDEITA 699
Cdd:TIGR01497 464 KTIMITGDNRLTAAAIAAEAGV-----------------DDF--------------IAEATPEDKIALIRQEQAEGKLVA 512
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|..
gi 36031132   700 MTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGR 751
Cdd:TIGR01497 513 MTGDGTNDAPALAQADVGVAMNSGTQAAKEAANMVDLDSDPTKLIEVVHIGK 564
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
35-776 6.62e-18

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 89.36  E-value: 6.62e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132     35 KYGP-NELPaeegKSLWElvveQFEDLLVRILLLAACISFVLAWFEEGEETVTAfveP--FVILLILIANAIVGvWQERN 111
Cdd:TIGR01652   10 KYTVlTFLP----KNLFE----QFKRFANLYFLVVALLQQVPILSPTYRGTSIV---PlaFVLIVTAIKEAIED-IRRRR 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    112 AEnaiealKEYEPEMGKVYRADRKSVqRIKARDIVPGDIVEVAVGDKVPADIRILS---------IKS------TTLRVD 176
Cdd:TIGR01652   78 RD------KEVNNRLTEVLEGHGQFV-EIPWKDLRVGDIVKVKKDERIPADLLLLSssepdgvcyVETanldgeTNLKLR 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    177 QSI------LTGESVS----VIKHTDP------------VPDPRAVNQDKKNMLFSGTNIAAGK-AVGIVATTGVSTEIG 233
Cdd:TIGR01652  151 QALeetqkmLDEDDIKnfsgEIECEQPnaslysfqgnmtINGDRQYPLSPDNILLRGCTLRNTDwVIGVVVYTGHDTKLM 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    234 KIRDQmaaTEQDKTPLQQKLDefgeQLSKVISLICVAVWLINI---GHFNDPVHGGSWFrgaIYYFKIAVALAVAAIPEG 310
Cdd:TIGR01652  231 RNATQ---APSKRSRLEKELN----FLIIILFCLLFVLCLISSvgaGIWNDAHGKDLWY---IRLDVSERNAAANGFFSF 300
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    311 LPAVI--------------------TTCLALGTRRM--AKKN--AIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKM 366
Cdd:TIGR01652  301 LTFLIlfsslipislyvslelvksvQAYFINSDLQMyhEKTDtpASVRTSNLNEELGQVEYIFSDKTGTLTQNIMEFKKC 380
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    367 FI-----IDKVDGDVCSL-----------NEFSITGSTYAPEGEVLKNDKPVRAGQYDGLVELATICALCNDSSLDFNET 430
Cdd:TIGR01652  381 SIagvsyGDGFTEIKDGIrerlgsyveneNSMLVESKGFTFVDPRLVDLLKTNKPNAKRINEFFLALALCHTVVPEFNDD 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    431 KGVyEKVGEAT---ETALTTLVEKMNVfntevrslSKVERANACNSVIRQLM--KKEF----TLEFSRDRKSMSVYCSPA 501
Cdd:TIGR01652  461 GPE-EITYQAAspdEAALVKAARDVGF--------VFFERTPKSISLLIEMHgeTKEYeilnVLEFNSDRKRMSVIVRNP 531
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    502 KSSRaavgnKMFVKGApegviDRCNYVRVgttrvpltgpvkEKIMSVIKEWGT------GRDTLRCLALATRD------- 568
Cdd:TIGR01652  532 DGRI-----KLLCKGA-----DTVIFKRL------------SSGGNQVNEETKehlenyASEGLRTLCIAYRElseeeye 589
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    569 ----------TPPKREEMVLDDSAKFMEYemDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAI--- 635
Cdd:TIGR01652  590 ewneeyneasTALTDREEKLDVVAESIEK--DLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVETAINIgys 667
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    636 CR-------RIGIFSENEEVTDRAYTGREFDDLPLAEQREA-------------------------------CRRA---- 673
Cdd:TIGR01652  668 CRllsrnmeQIVITSDSLDATRSVEAAIKFGLEGTSEEFNNlgdsgnvalvidgkslgyaldeelekeflqlALKCkavi 747
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132    674 CCfaRVEPSHKSKIVEYLQ-SYDEITAMTGDGVNDAPALKKAEIGIAM-GSGTAVAKTASEMVLADDNFSTIVAAVeEGR 751
Cdd:TIGR01652  748 CC--RVSPSQKADVVRLVKkSTGKTTLAIGDGANDVSMIQEADVGVGIsGKEGMQAVMASDFAIGQFRFLTKLLLV-HGR 824
                          890       900
                   ....*....|....*....|....*
gi 36031132    752 AIYNNMKQFIRYLISSNVGEVVCIF 776
Cdd:TIGR01652  825 WSYKRISKMILYFFYKNLIFAIIQF 849
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
67-743 1.83e-16

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 84.10  E-value: 1.83e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132  67 LAACISFVLAWFE--EGEETVT-AFVEPFVILLiLIANAIVGVWQERNAEnaiEALKEYEPemGKVYRADRKSVQRIKAR 143
Cdd:cd07553  69 LGIVIGFVVSWYGliKGDGLVYfDSLSVLVFLM-LVGRWLQVVTQERNRN---RLADSRLE--APITEIETGSGSRIKTR 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 144 --DIVPGDIVEVAVGDKVPADIRILSIKSTtlrVDQSILTGESVSVIKHTDpvpdpravnqDKknmLFSGTNIAAGKAVG 221
Cdd:cd07553 143 adQIKSGDVYLVASGQRVPVDGKLLSEQAS---IDMSWLTGESLPRIVERG----------DK---VPAGTSLENQAFEI 206
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 222 IVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVA---VWL---INIGhfndpvhggswfrgaiyy 295
Cdd:cd07553 207 RVEHSLAESWSGSILQKVEAQEARKTPRDLLADKIIHYFTVIALLIAVAgfgVWLaidLSIA------------------ 268
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 296 FKIAVALAVAAIPEGLpaVITTCLALGT--RRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSvckmFIidKVD 373
Cdd:cd07553 269 LKVFTSVLIVACPCAL--ALATPFTDEIalARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRGKSS----FV--MVN 340
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 374 GDVCSLNEfsitgstyapegevlkndkpvragqydgLVELATICALCNDSsldfnetkgvyekvgeatetalttlvekmn 453
Cdd:cd07553 341 PEGIDRLA----------------------------LRAISAIEAHSRHP------------------------------ 362
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 454 VFNTEVRSLSKVERANACNSVIRQLMKKEftlefsrdrksmsvycspakssraavgnkmfVKGAPEGvidrcNYVRVGTT 533
Cdd:cd07553 363 ISRAIREHLMAKGLIKAGASELVEIVGKG-------------------------------VSGNSSG-----SLWKLGSA 406
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 534 rvpltgpvkekimsvikewgtgrdtlrCLALATRDTPpkreemvlddsakfMEYEMDLTFVGVVGMLDPPRKEVTGSIQL 613
Cdd:cd07553 407 ---------------------------PDACGIQESG--------------VVIARDGRQLLDLSFNDLLRPDSNREIEE 445
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 614 CRDAGIRVIMITGDNKGTAiaicRRIGifseneevtdraytgrefDDLPLAEqREAcrraccFARVEPSHKSKIVEYLQS 693
Cdd:cd07553 446 LKKGGLSIAILSGDNEEKV----RLVG------------------DSLGLDP-RQL------FGNLSPEEKLAWIESHSP 496
                       650       660       670       680       690
                ....*....|....*....|....*....|....*....|....*....|
gi 36031132 694 ydEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTI 743
Cdd:cd07553 497 --ENTLMVGDGANDALALASAFVGIAVAGEVGVSLEAADIYYAGNGIGGI 544
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
485-775 8.98e-14

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 75.71  E-value: 8.98e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 485 LEFSRDRKSMSVYCSPAKSSRAavgnKMFVKGAPEGVIDRCNyvrvgttrvplTGPVKEKIMSVIKEWGTgrDTLRCLAL 564
Cdd:cd07536 397 LEFTSDRKRMSVIVRDESTGEI----TLYMKGADVAISPIVS-----------KDSYMEQYNDWLEEECG--EGLRTLCV 459
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 565 ATRDTppkREEMVLDDSAKFME------------------YEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITG 626
Cdd:cd07536 460 AKKAL---TENEYQEWESRYTEaslslhdrslrvaevvesLERELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTG 536
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 627 DNKGTAIAI---CRRIG------IFSENEEVTDRAYTGREFDDLPLAEQRE----------------------------A 669
Cdd:cd07536 537 DKQETAICIaksCHLVSrtqdihLLRQDTSRGERAAITQHAHLELNAFRRKhdvalvidgdslevalkyyrhefvelacQ 616
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 670 CRRACCfARVEPSHKSKIVEYLQSYDE-ITAMTGDGVNDAPALKKAEIGIAM-GSGTAVAKTASEMVLADDNFSTIVAAV 747
Cdd:cd07536 617 CPAVIC-CRVSPTQKARIVTLLKQHTGrRTLAIGDGGNDVSMIQAADCGVGIsGKEGKQASLAADYSITQFRHLGRLLLV 695
                       330       340
                ....*....|....*....|....*...
gi 36031132 748 eEGRAIYNNMKQFIRYLISSNVgeVVCI 775
Cdd:cd07536 696 -HGRNSYNRSAALGQYVFYKGL--IIST 720
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
110-759 1.06e-13

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 75.09  E-value: 1.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 110 RNAENAIEALKEYEPEMGKVYRADrKSVQRIKARDIVPGDIVEVAVGDKVPADIRILsikSTTLRVDQSILTGESVsvik 189
Cdd:cd02092 111 GRARSAAEELAALEARGAQRLQAD-GSREYVPVAEIRPGDRVLVAAGERIPVDGTVV---SGTSELDRSLLTGESA---- 182
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 190 htdpvpdPRAVNQDkkNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKV---ISL 266
Cdd:cd02092 183 -------PVTVAPG--DLVQAGAMNLSGPLRLRATAAGDDTLLAEIARLMEAAEQGRSRYVRLADRAARLYAPVvhlLAL 253
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 267 ICVAVWLInighfndpvHGGSWfRGAIyyfkiavalavaaipegLPAV---ITTC-LALG----------TRRMAKKNAI 332
Cdd:cd02092 254 LTFVGWVA---------AGGDW-RHAL-----------------LIAVavlIITCpCALGlavpavqvvaSGRLFRRGVL 306
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 333 VRSLPSVETLGCTSVICSDKTGTLTTNQMSVckmfiidkVDGDVCSLNEFSITG----STYAPEGEVLKNDKPVRAGQYD 408
Cdd:cd02092 307 VKDGTALERLAEVDTVVFDKTGTLTLGSPRL--------VGAHAISADLLALAAalaqASRHPLSRALAAAAGARPVELD 378
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 409 GLVELAticalcndssldfneTKGVYEKVGEATetalttlvekmnvfnteVRSlskveranacnsvirqlmkkeftlefs 488
Cdd:cd02092 379 DAREVP---------------GRGVEGRIDGAR-----------------VRL--------------------------- 399
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 489 rdrksmsvycspakSSRAAVGNKMFVKGAPEgvidrcnyvrvgttrVPLTGPVKEKImsvikewgtgrdtlrCLALAtrd 568
Cdd:cd02092 400 --------------GRPAWLGASAGVSTASE---------------LALSKGGEEAA---------------RFPFE--- 432
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 569 tppkreemvlddsakfmeyemdltfvgvvgmlDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIfseneev 648
Cdd:cd02092 433 --------------------------------DRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGI------- 473
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 649 tDRAYTGrefddlplaeqreacrraccfarVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAK 728
Cdd:cd02092 474 -EDWRAG-----------------------LTPAEKVARIEELKAQGRRVLMVGDGLNDAPALAAAHVSMAPASAVDASR 529
                       650       660       670
                ....*....|....*....|....*....|.
gi 36031132 729 TASEMVLADDNFSTIVAAVEEGRAIYNNMKQ 759
Cdd:cd02092 530 SAADIVFLGDSLAPVPEAIEIARRARRLIRQ 560
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
590-751 9.61e-12

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 68.80  E-value: 9.61e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 590 DLTFVGVVGMLDPPRKEVTGSIQLCRDAGI-RVIMITGDNKGTAIAICRRIGIfseneevtDRAYTGRefddLPlAEQRE 668
Cdd:cd07548 417 DGKYVGYIVISDEIKEDAKEAIKGLKELGIkNLVMLTGDRKSVAEKVAKKLGI--------DEVYAEL----LP-EDKVE 483
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 669 AcrraccFARVEPSHKSKIveylqsydeitAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKTASEMVLADDNFSTIVAAV 747
Cdd:cd07548 484 K------VEELKAESKGKV-----------AFVGDGINDAPVLARADVGIAMGGlGSDAAIEAADVVLMNDEPSKVAEAI 546

                ....
gi 36031132 748 EEGR 751
Cdd:cd07548 547 KIAR 550
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
140-741 4.60e-11

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 67.05  E-value: 4.60e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 140 IKARDIVPGDIVEVAVGDKVPADIRIL--SIKSTT--LRVDQsiLTGE----------------------SVSVIKHTDP 193
Cdd:cd07541  94 IPSSDIKVGDLIIVEKNQRIPADMVLLrtSEKSGScfIRTDQ--LDGEtdwklriavpctqklpeegilnSISAVYAEAP 171
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 194 VPD-------------PRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTeigkiRDQMAATE-QDKTPLqqkLDEFGEQ 259
Cdd:cd07541 172 QKDihsfygtftinddPTSESLSVENTLWANTVVASGTVIGVVVYTGKET-----RSVMNTSQpKNKVGL---LDLEINF 243
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 260 LSKVI--SLICVAVWLINIGHFndpvhGGSWFRGAIYY---FKIAvalavaaipegLPAVITTCLALGTRRMAK-----K 329
Cdd:cd07541 244 LTKILfcAVLALSIVMVALQGF-----QGPWYIYLFRFlilFSSI-----------IPISLRVNLDMAKIVYSWqiehdK 307
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 330 N---AIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDV----CSLNEFSITGSTyAPEGEVLKNDKpv 402
Cdd:cd07541 308 NipgTVVRTSTIPEELGRIEYLLSDKTGTLTQNEMVFKKLHLGTVSYGGQnlnyEILQIFPFTSES-KRMGIIVREEK-- 384
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 403 ragqyDGLVELaticalcndssldfnetkgvYEKvgeATETALTTLVEKMNVFNTEvrslskveranaCNSVIRQLMKke 482
Cdd:cd07541 385 -----TGEITF--------------------YMK---GADVVMSKIVQYNDWLEEE------------CGNMAREGLR-- 422
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 483 fTLEFSRDRKSMSVYCSPAKSSRAAvgnKMFVkgapegvidrcnyvrvgTTRVpltgpvkEKIMSVIKewgtgrdtlrcl 562
Cdd:cd07541 423 -TLVVAKKKLSEEEYQAFEKRYNAA---KLSI-----------------HDRD-------LKVAEVVE------------ 462
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 563 alatrdtppkreemvlddsakFMEYEMDLtfVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIF 642
Cdd:cd07541 463 ---------------------SLERELEL--LCLTGVEDKLQEDVKPTLELLRNAGIKIWMLTGDKLETATCIAKSSKLV 519
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 643 SENEE------VTDRAYTGREFDDLPL---------AEQREACRR----------------ACCfaRVEPSHKSKIVEYL 691
Cdd:cd07541 520 SRGQYihvfrkVTTREEAHLELNNLRRkhdcalvidGESLEVCLKyyehefielacqlpavVCC--RCSPTQKAQIVRLI 597
                       650       660       670       680       690
                ....*....|....*....|....*....|....*....|....*....|.
gi 36031132 692 QSYDEI-TAMTGDGVNDAPALKKAEIGIAMgsgtaVAKTASEMVLADDnFS 741
Cdd:cd07541 598 QKHTGKrTCAIGDGGNDVSMIQAADVGVGI-----EGKEGKQASLAAD-FS 642
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
588-714 1.05e-09

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 59.14  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   588 EMDLTFVGVVGMLDP--PRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSENEEVTDRAYTGrefddlplae 665
Cdd:pfam00702  82 VVLVELLGVIALADElkLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVG---------- 151
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 36031132   666 qreacrraccFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKA 714
Cdd:pfam00702 152 ----------VGKPKPEIYLAALERLGVKPEEVLMVGDGVNDIPAAKAA 190
PLN03190 PLN03190
aminophospholipid translocase; Provisional
334-776 1.62e-09

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 62.22  E-value: 1.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   334 RSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFI--IDKVDGDVCSLNE-----FSITGSTYAPEGEV---------LK 397
Cdd:PLN03190  442 RALNINEDLGQIKYVFSDKTGTLTENKMEFQCASIwgVDYSDGRTPTQNDhagysVEVDGKILRPKMKVkvdpqllelSK 521
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   398 NDKPVRAGQ--YDGLVELA---TICALCNDSSLDFNETKGVYEkvGEATEtalttlvEKMNVFNTEVRSLSKVERANACN 472
Cdd:PLN03190  522 SGKDTEEAKhvHDFFLALAacnTIVPIVVDDTSDPTVKLMDYQ--GESPD-------EQALVYAAAAYGFMLIERTSGHI 592
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   473 SVIRQLMKKEFTL----EFSRDRKSMSVYCS-PAKSSraavgnKMFVKGAPE---GVIDRC-NYVRVGTTRVPLTGpvke 543
Cdd:PLN03190  593 VIDIHGERQRFNVlglhEFDSDRKRMSVILGcPDKTV------KVFVKGADTsmfSVIDRSlNMNVIRATEAHLHT---- 662
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   544 kimsvikewgTGRDTLRCLALATRDtppkreemvLDDSaKFMEY-------------------------EMDLTFVGVVG 598
Cdd:PLN03190  663 ----------YSSLGLRTLVVGMRE---------LNDS-EFEQWhfsfeaastaligraallrkvasnvENNLTILGASA 722
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   599 MLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAI-----------------------CRR--------------IGI 641
Cdd:PLN03190  723 IEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISIgyssklltnkmtqiiinsnskesCRKsledalvmskklttVSG 802
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   642 FSENEEVTDRAYTG----------------REFDDLpLAEQREACRRACCfARVEPSHKSKIVEYLQS-YDEITAMTGDG 704
Cdd:PLN03190  803 ISQNTGGSSAAASDpvaliidgtslvyvldSELEEQ-LFQLASKCSVVLC-CRVAPLQKAGIVALVKNrTSDMTLAIGDG 880
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 36031132   705 VNDAPALKKAEIGIAM-GSGTAVAKTASEMVLADDNFSTIVAAVeEGRAIYNNMKQFIRYLISSNVGEVVCIF 776
Cdd:PLN03190  881 ANDVSMIQMADVGVGIsGQEGRQAVMASDFAMGQFRFLVPLLLV-HGHWNYQRMGYMILYNFYRNAVFVLVLF 952
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
685-739 6.40e-05

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 45.72  E-value: 6.40e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 36031132   685 SKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDN 739
Cdd:TIGR00099 194 QSLAEALGISLEDVIAFGDGMNDIEMLEAAGYGVAMGNADEELKALADYVTDSNN 248
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
683-739 2.79e-04

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 43.77  E-value: 2.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 36031132   683 HKSKIVEYLQSY-----DEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDN 739
Cdd:pfam08282 187 SKGTALKALAKHlnislEEVIAF-GDGENDIEMLEAAGLGVAMGNASPEVKAAADYVTDSNN 247
HAD pfam12710
haloacid dehalogenase-like hydrolase;
611-712 7.69e-04

haloacid dehalogenase-like hydrolase;


Pssm-ID: 432733 [Multi-domain]  Cd Length: 188  Bit Score: 41.75  E-value: 7.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132   611 IQLCRDAGIRVIMITGDNKGTAIAICRRIG---IFSENEEVTDRAYTGREFDDLPLAEQREACRR--ACCFARVEPSHKS 685
Cdd:pfam12710  93 LAAHRAAGDRVVVVTGGLRPLVEPVLAELGfdeVLATELEVDDGRFTGELRLIGPPCAGEGKVRRlrAWLAARGLGLDLA 172
                          90       100
                  ....*....|....*....|....*..
gi 36031132   686 KIVEYlqsydeitamtGDGVNDAPALK 712
Cdd:pfam12710 173 DSVAY-----------GDSPSDLPMLR 188
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
685-760 2.14e-03

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 40.67  E-value: 2.14e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 36031132 685 SKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNfstivaavEEGraIYNNMKQF 760
Cdd:cd07517 147 QKVIEHLGIKKEETMAFGDGLNDIEMLEAVGIGIAMGNAHEELKEIADYVTKDVD--------EDG--ILKALKHF 212
SerB COG0560
Phosphoserine phosphatase [Amino acid transport and metabolism]; Phosphoserine phosphatase is ...
611-733 3.51e-03

Phosphoserine phosphatase [Amino acid transport and metabolism]; Phosphoserine phosphatase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 440326 [Multi-domain]  Cd Length: 221  Bit Score: 40.21  E-value: 3.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 36031132 611 IQLCRDAGIRVIMITGDNKGTAIAICRRIGI---FSeNE-EVTDRAYTGREFDDLPLAEQ-REACRRaccFARvepshks 685
Cdd:COG0560  97 IAEHRAAGHKVAIVSGGFTFFVEPIAERLGIdhvIA-NElEVEDGRLTGEVVGPIVDGEGkAEALRE---LAA------- 165
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 36031132 686 kivEYLQSYDEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKTASEM 733
Cdd:COG0560 166 ---ELGIDLEQSYAY-GDSANDLPMLEAAGLPVAVNPDPALREAADRE 209
HAD_Pase cd07516
phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the ...
685-749 5.82e-03

phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily; Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319818 [Multi-domain]  Cd Length: 253  Bit Score: 39.50  E-value: 5.82e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 36031132 685 SKIVEYLQ-SYDEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEE 749
Cdd:cd07516 189 KKLAEYLGiSLEEVIAF-GDNENDLSMLEYAGLGVAMGNAIDEVKEAADYVTLTNNEDGVAKAIEK 253
serB TIGR00338
phosphoserine phosphatase SerB; Phosphoserine phosphatase catalyzes the reaction ...
679-730 7.52e-03

phosphoserine phosphatase SerB; Phosphoserine phosphatase catalyzes the reaction 3-phospho-serine + H2O = L-serine + phosphate. It catalyzes the last of three steps in the biosynthesis of serine from D-3-phosphoglycerate. Note that this enzyme acts on free phosphoserine, not on phosphoserine residues of phosphoproteins. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273022 [Multi-domain]  Cd Length: 219  Bit Score: 38.88  E-value: 7.52e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 36031132   679 VEPSHKSKIVEYLQSYDEI----TAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTA 730
Cdd:TIGR00338 148 VDASYKGKTLLILLRKEGIspenTVAVGDGANDLSMIKAAGLGIAFNAKPKLQQKA 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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