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Conserved domains on  [gi|41281398|ref|NP_031399|]
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leucine-rich repeat protein SHOC-2 isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-448 1.30e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 1.30e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 114 ILPSSIKELTQLTELYLYSNKlqslpaEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 194 LTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 274 LDLPDtIGNLSSLSRLGLRYNRLSAIPrSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Cdd:COG4886 241 TDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433
Cdd:COG4886 319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                       330
                ....*....|....*
gi 41281398 434 NNLLKKLPHGLGNLR 448
Cdd:COG4886 399 GVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 3.30e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 3.30e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLlkklphGLGNLRKLRELDLEENKLESLPNE 466
Cdd:COG4886  58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 467 IAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIM 546
Cdd:COG4886 132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEEL 210

                       170
                ....*....|....
gi 41281398 547 SIENCPLSHLPPQI 560
Cdd:COG4886 211 DLSGNQLTDLPEPL 224
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-448 1.30e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 1.30e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 114 ILPSSIKELTQLTELYLYSNKlqslpaEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 194 LTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 274 LDLPDtIGNLSSLSRLGLRYNRLSAIPrSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Cdd:COG4886 241 TDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433
Cdd:COG4886 319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                       330
                ....*....|....*
gi 41281398 434 NNLLKKLPHGLGNLR 448
Cdd:COG4886 399 GVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 3.30e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 3.30e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLlkklphGLGNLRKLRELDLEENKLESLPNE 466
Cdd:COG4886  58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 467 IAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIM 546
Cdd:COG4886 132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEEL 210

                       170
                ....*....|....
gi 41281398 547 SIENCPLSHLPPQI 560
Cdd:COG4886 211 DLSGNQLTDLPEPL 224
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-483 1.73e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 105.32  E-value: 1.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  115 LPSSIKELTQLTELYLYSNKLQ-SLPAEVGCLVNLMTLALSENSLTSlpdsldnlkklrmldlrhnklrEIPSVVYRLDS 193
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSG----------------------EIPELVIQLQN 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  194 LTTLYLRFNRIT-TVEKDIKNLSKLSMLSIRENKIK-QLPAEIGELCNLITLDVAHNQLE-HLPKEIGNCTQITNLDLQH 270
Cdd:PLN00113 310 LEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFS 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  271 NELLD-LPDTIGNLSSLSRLGLRYNRLSA-IPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFqlypV 348
Cdd:PLN00113 390 NSLEGeIPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF----F 465

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  349 GGPSQFS---TIYSLNMEHNRINK-IP--FGIFSRakvLSKLNMKDNQLTS-LPLDFGTWTSMVELNLATNQLT-KIPED 420
Cdd:PLN00113 466 GGLPDSFgskRLENLDLSRNQFSGaVPrkLGSLSE---LMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPAS 542

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41281398  421 VSGLVSLEVLILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQL 483
Cdd:PLN00113 543 FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFLAINASAVAGNIDL 607
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 360-528 3.09e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.99  E-value: 3.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 360 LNMEHNRINKIpfGIFSRAKVLSKLNMKDNQLTSLPlDFGTWTSMVELNLATNQLTKIpEDVSGLVSLEVLILSNNLLKK 439
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 440 LpHGLGNLRKLRELDLE------ENKLESLPNEIAYLKD-LQKLVLTNNQLTTLpRGIGHLTNLTHLGLGENLLTHLPE- 511
Cdd:cd21340  83 V-EGLENLTNLEELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEEl 160

                       170
                ....*....|....*....
gi 41281398 512 --EIGTLENLEELYLNDNP 528
Cdd:cd21340 161 ldLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-562 1.52e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.36  E-value: 1.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  353 QFSTIYSLNMEHNRIN-KIPFGIFSRAKVLSKLNMKDNQLTSlPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVL 430
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  431 ILSNN-LLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT 507
Cdd:PLN00113 170 DLGGNvLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLT 249

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 41281398  508 -HLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
Cdd:PLN00113 250 gPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVI 305
LRR_8 pfam13855
Leucine rich repeat;
123-181 5.38e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 5.38e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41281398   123 TQLTELYLYSNKLQSLPAEV-GCLVNLMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKL 181
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 383-528 4.08e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 4.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTK----IPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLR-KLRE 452
Cdd:cd00116  62 ETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPdgcgVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPpALEK 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 453 LDLEENKL-----ESLPNEIAYLKDLQKLVLTNNQL-----TTLPRGIGHLTNLTHLGLGENLLTH-----LPEEIGTLE 517
Cdd:cd00116 142 LVLGRNRLegascEALAKALRANRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTDegasaLAETLASLK 221

                       170
                ....*....|.
gi 41281398 518 NLEELYLNDNP 528
Cdd:cd00116 222 SLEVLNLGDNN 232
LRR_8 pfam13855
Leucine rich repeat;
426-483 1.75e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.75e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398   426 SLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQL 483
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-448 1.30e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.22  E-value: 1.30e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 114 ILPSSIKELTQLTELYLYSNKlqslpaEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 194 LTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 274 LDLPDtIGNLSSLSRLGLRYNRLSAIPrSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Cdd:COG4886 241 TDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433
Cdd:COG4886 319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                       330
                ....*....|....*
gi 41281398 434 NNLLKKLPHGLGNLR 448
Cdd:COG4886 399 GVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-498 6.73e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.05  E-value: 6.73e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  81 TRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 161 LPDSLDNLKKLRMLDLRHNKLreipsvVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNL 240
Cdd:COG4886  88 GLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 241 ITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS 320
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 321 TLPEslLSSLVKLNSLTLARNcfQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT 400
Cdd:COG4886 242 DLPE--LGNLTNLEELDLSNN--QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 401 WTsMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTN 480
Cdd:COG4886 318 LL-LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTT 396

                       410
                ....*....|....*...
gi 41281398 481 NQLTTLPRGIGHLTNLTH 498
Cdd:COG4886 397 TAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
144-539 7.69e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.88  E-value: 7.69e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 144 CLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIR 223
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 224 ENKIKQLPAEIGELCNLITLDVAHNqlehlpKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSL 303
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 304 AKCSAleelnlennnistlpesllsslvklnsltlarncfqlypvggpsqfstiyslnmehnrinkipfgifsrakvLSK 383
Cdd:COG4886 156 GNLTN------------------------------------------------------------------------LKS 163

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 384 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESL 463
Cdd:COG4886 164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41281398 464 PnEIAYLKDLQKLVLTNNQLTTLPrGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELAL 539
Cdd:COG4886 244 P-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
319-557 1.46e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.11  E-value: 1.46e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 319 ISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDF 398
Cdd:COG4886   7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 399 GTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVL 478
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDL 166

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41281398 479 TNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIMSIENCPLSHLP 557
Cdd:COG4886 167 SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 3.30e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 3.30e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLlkklphGLGNLRKLRELDLEENKLESLPNE 466
Cdd:COG4886  58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 467 IAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELALCSKLSIM 546
Cdd:COG4886 132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNN-QITDLPEPLGNLTNLEEL 210

                       170
                ....*....|....
gi 41281398 547 SIENCPLSHLPPQI 560
Cdd:COG4886 211 DLSGNQLTDLPEPL 224
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-483 1.73e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 105.32  E-value: 1.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  115 LPSSIKELTQLTELYLYSNKLQ-SLPAEVGCLVNLMTLALSENSLTSlpdsldnlkklrmldlrhnklrEIPSVVYRLDS 193
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSG----------------------EIPELVIQLQN 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  194 LTTLYLRFNRIT-TVEKDIKNLSKLSMLSIRENKIK-QLPAEIGELCNLITLDVAHNQLE-HLPKEIGNCTQITNLDLQH 270
Cdd:PLN00113 310 LEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFS 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  271 NELLD-LPDTIGNLSSLSRLGLRYNRLSA-IPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFqlypV 348
Cdd:PLN00113 390 NSLEGeIPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF----F 465

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  349 GGPSQFS---TIYSLNMEHNRINK-IP--FGIFSRakvLSKLNMKDNQLTS-LPLDFGTWTSMVELNLATNQLT-KIPED 420
Cdd:PLN00113 466 GGLPDSFgskRLENLDLSRNQFSGaVPrkLGSLSE---LMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPAS 542

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41281398  421 VSGLVSLEVLILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQL 483
Cdd:PLN00113 543 FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFLAINASAVAGNIDL 607
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 101-543 2.81e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 104.93  E-value: 2.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  101 NSMR---LDLSKRSIH-ILPSSIKELTQLTELYLYSNKLQ-SLPAEVGCLV-NLMTLALSENSLTSlPDSLDNLKKLRML 174
Cdd:PLN00113  67 NSSRvvsIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTG-SIPRGSIPNLETL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  175 DLRHNKLR-EIPSVVYRLDSLTTLYLRFNRIT-TVEKDIKNLSKLSMLSIRENK-IKQLPAEIGELCNLITLDVAHNQLE 251
Cdd:PLN00113 146 DLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLS 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  252 -HLPKEIGNCTQITNLDLQHNELL-DLPDTIGNLSSLSRLGLRYNRLSA-IPRSLAkcsaleelnlennnistlpeslls 328
Cdd:PLN00113 226 gEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIF------------------------ 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  329 SLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRIN-KIPFGIFSRAKvLSKLNMKDNQLT-SLPLDFGTWTSMVE 406
Cdd:PLN00113 282 SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPR-LQVLQLWSNKFSgEIPKNLGKHNNLTV 360

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  407 LNLATNQLT-KIPEDVSGLVSLEVLIL-SNNLLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQL 483
Cdd:PLN00113 361 LDLSTNNLTgEIPEGLCSSGNLFKLILfSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL 440

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  484 T-------------------------TLPRGIGHlTNLTHLGLGENLLTH-LPEEIGTLENLEELYLNDNPNLHSLPFEL 537
Cdd:PLN00113 441 QgrinsrkwdmpslqmlslarnkffgGLPDSFGS-KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEIPDEL 519


                 ....*.
gi 41281398  538 ALCSKL 543
Cdd:PLN00113 520 SSCKKL 525
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
78-326 4.07e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 94.76  E-value: 4.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398   78 APgTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKEltQLTELYLYSNKLQSLPAEVGClvNLMTLALSENS 157
Cdd:PRK15370 157 AP-AKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQG--NIKTLYANSNQ 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  158 LTSLPDSLDNlkKLRMLDLRHNKLREIPSvvyRLDS-LTTLYLRFNRITTVEKDIKNlsKLSMLSIRENKIKQLPAE--- 233
Cdd:PRK15370 232 LTSIPATLPD--TIQEMELSINRITELPE---RLPSaLQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHlps 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  234 -IGEL---------------CNLITLDVAHNQLEHLPKEIGncTQITNLDLQHNELLDLPDTIGnlSSLSRLGLRYNRLS 297
Cdd:PRK15370 305 gITHLnvqsnsltalpetlpPGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALT 380

                        250       260
                 ....*....|....*....|....*....
gi 41281398  298 AIPRSLAkcSALEELNLENNNISTLPESL 326
Cdd:PRK15370 381 NLPENLP--AALQIMQASRNNLVRLPESL 407
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
262-554 4.19e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 88.22  E-value: 4.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  262 QITNLDLQHNELLDLPDTI-GNLSSLSrlgLRYNRLSAIPrslakcsaleelnlennniSTLPESLlsslvklNSLTLAR 340
Cdd:PRK15370 200 QITTLILDNNELKSLPENLqGNIKTLY---ANSNQLTSIP-------------------ATLPDTI-------QEMELSI 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  341 NCFQLYPVGGPSqfsTIYSLNMEHNRINKIPFGIfsrAKVLSKLNMKDNQLTSLPLDFGTwtSMVELNLATNQLTKIPED 420
Cdd:PRK15370 251 NRITELPERLPS---ALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPET 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  421 VSglVSLEVLILSNNLLKKLPhglgnlrklreldleenklESLPNEiaylkdLQKLVLTNNQLTTLPRGIGhlTNLTHLG 500
Cdd:PRK15370 323 LP--PGLKTLEAGENALTSLP-------------------ASLPPE------LQVLDVSKNQITVLPETLP--PTITTLD 373

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 41281398  501 LGENLLTHLPEEI-GTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 554
Cdd:PRK15370 374 VSRNALTNLPENLpAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVEYNPFS 428
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 360-528 3.09e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.99  E-value: 3.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 360 LNMEHNRINKIpfGIFSRAKVLSKLNMKDNQLTSLPlDFGTWTSMVELNLATNQLTKIpEDVSGLVSLEVLILSNNLLKK 439
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 440 LpHGLGNLRKLRELDLE------ENKLESLPNEIAYLKD-LQKLVLTNNQLTTLpRGIGHLTNLTHLGLGENLLTHLPE- 511
Cdd:cd21340  83 V-EGLENLTNLEELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEEl 160

                       170
                ....*....|....*....
gi 41281398 512 --EIGTLENLEELYLNDNP 528
Cdd:cd21340 161 ldLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-414 4.93e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.90  E-value: 4.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  115 LPSSIKELTQLTELYL-YSNKLQSLPAEVGCLVNLMTLALSENSLT-SLPDSLDNLKKLRMLDLRHNKLR-EIPSVVYRL 191
Cdd:PLN00113 228 IPYEIGGLTSLNHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQL 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  192 DSLTTLYLRFNRIT-TVEKDIKNLSKLSMLSIRENKIK-QLPAEIGELCNLITLDVAHNQLE------------------ 251
Cdd:PLN00113 308 QNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgeipeglcssgnlfklil 387

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  252 -------HLPKEIGNCTQITNLDLQHN----------------------------------------ELLDL-------- 276
Cdd:PLN00113 388 fsnslegEIPKSLGACRSLRRVRLQDNsfsgelpseftklplvyfldisnnnlqgrinsrkwdmpslQMLSLarnkffgg 467

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  277 -PDTIGNlSSLSRLGLRYNRLS-AIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLnsltlarncfqlypvggpsqf 354
Cdd:PLN00113 468 lPDSFGS-KRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKL--------------------- 525

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41281398  355 stiYSLNMEHNRIN-KIPFGiFSRAKVLSKLNMKDNQLT-SLPLDFGTWTSMVELNLATNQL 414
Cdd:PLN00113 526 ---VSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-562 1.52e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.36  E-value: 1.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  353 QFSTIYSLNMEHNRIN-KIPFGIFSRAKVLSKLNMKDNQLTSlPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVL 430
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  431 ILSNN-LLKKLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT 507
Cdd:PLN00113 170 DLGGNvLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLT 249

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 41281398  508 -HLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
Cdd:PLN00113 250 gPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVI 305
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 122-301 8.29e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.67  E-value: 8.29e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 122 LTQLTELYLYSNKLQSLPAEVGCLvNLMTLALSENSLTSLPDsLDNLKKLRMLDLRHNKLREIPSVVyRLDSLTTLYLRF 201
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIENLE-NLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 202 NRITTVEkDIKNLSKLSMLSI------RENKIKQLPAEIGELCN-LITLDVAHNQLEHLpKEIGNCTQITNLDLQHNELL 274
Cdd:cd21340  78 NRISVVE-GLENLTNLEELHIenqrlpPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155

                       170       180       190
                ....*....|....*....|....*....|
gi 41281398 275 DLPD---TIGNLSSLSRLGLRYNRLSAIPR 301
Cdd:cd21340 156 DLEElldLLSSWPSLRELDLTGNPVCKKPK 185
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
73-460 1.18e-12

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 70.96  E-value: 1.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398   73 KRPNPAPGTRKKssnAEVIKELNKCREENSMRLDLSKRSIHILPSSIKelTQLTELYLYSNKLQSLPAevgCLVNLMTLA 152
Cdd:PRK15387 177 RRAAPAEESRGR---AAVVQKMRACLNNGNAVLNVGESGLTTLPDCLP--AHITTLVIPDNNLTSLPA---LPPELRTLE 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  153 LSENSLTSLPDSLDNLKKLRMLDlrhNKLREIPSVVyrlDSLTTLYLRFNRITTVEKDIKNLSKLSmlsIRENKIKQLPA 232
Cdd:PRK15387 249 VSGNQLTSLPVLPPGLLELSIFS---NPLTHLPALP---SGLCKLWIFGNQLTSLPVLPPGLQELS---VSDNQLASLPA 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  233 EIGELCNLITLDvahNQLEHLPKeignctqitnldlqhnelldLPdtignlSSLSRLGLRYNRLSAIPrslakcsaleel 312
Cdd:PRK15387 320 LPSELCKLWAYN---NQLTSLPT--------------------LP------SGLQELSVSDNQLASLP------------ 358

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  313 nlennnisTLPesllsslvklnsltlarncfqlypvggpsqfSTIYSLNMEHNRINKIPfgifSRAKVLSKLNMKDNQLT 392
Cdd:PRK15387 359 --------TLP-------------------------------SELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLT 395

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41281398  393 SLPLdfgTWTSMVELNLATNQLTKIPEDVSGLVSLEVLilsNNLLKKLPHGLGNLRKLRELDLEENKL 460
Cdd:PRK15387 396 SLPV---LPSELKELMVSGNRLTSLPMLPSGLLSLSVY---RNQLTRLPESLIHLSSETTVNLEGNPL 457
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 322-554 1.18e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.95  E-value: 1.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  322 LPESLLSSLVKLNSLTLARNCFQLYPVGGpsQFSTIYSLNMEHNRIN-KIP--FGIFSRAKVLsklNMKDNQLTS-LPLD 397
Cdd:PLN00113 109 IPDDIFTTSSSLRYLNLSNNNFTGSIPRG--SIPNLETLDLSNNMLSgEIPndIGSFSSLKVL---DLGGNVLVGkIPNS 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  398 FGTWTSMVELNLATNQLT-------------------------KIPEDVSGLVSLEVL-ILSNNLLKKLPHGLGNLRKLR 451
Cdd:PLN00113 184 LTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnlsgEIPYEIGGLTSLNHLdLVYNNLTGPIPSSLGNLKNLQ 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  452 ELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT-HLPEEIGTLENLEELYLNDNP 528
Cdd:PLN00113 264 YLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNK 343

                        250       260
                 ....*....|....*....|....*.
gi 41281398  529 NLHSLPFELALCSKLSIMSIENCPLS 554
Cdd:PLN00113 344 FSGEIPKNLGKHNNLTVLDLSTNNLT 369
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
379-560 4.22e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 4.22e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 379 KVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN 458
Cdd:COG4886   4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 459 KLESLPNEIAYLKDLQKLVLTNNQlttlprGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNpNLHSLPFELA 538
Cdd:COG4886  84 LLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNN-QLTDLPEPLG 156

                       170       180
                ....*....|....*....|..
gi 41281398 539 LCSKLSIMSIENCPLSHLPPQI 560
Cdd:COG4886 157 NLTNLKSLDLSNNQLTDLPEEL 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
215-522 4.37e-11

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 65.95  E-value: 4.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  215 SKLSMLSIRENKIKQLPAEIGELcnlITLDVAHNQLEHLPKEIGNctqITNLDLQHNELLDLPDTIGNLSSLSRLGLRYN 294
Cdd:PRK15387 222 AHITTLVIPDNNLTSLPALPPEL---RTLEVSGNQLTSLPVLPPG---LLELSIFSNPLTHLPALPSGLCKLWIFGNQLT 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  295 RLSAIPRSLAKCSaleelnlennnistLPESLLSSLVKLnsltlarncfqlypvggPSQFSTIYSLNMEHNRINKIPFGi 374
Cdd:PRK15387 296 SLPVLPPGLQELS--------------VSDNQLASLPAL-----------------PSELCKLWAYNNQLTSLPTLPSG- 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  375 fsrakvLSKLNMKDNQLTSLPLdfgTWTSMVELNLATNQLTKIPEDVSGLvslEVLILSNNLLKKLPHGLGnlrKLRELD 454
Cdd:PRK15387 344 ------LQELSVSDNQLASLPT---LPSELYKLWAYNNRLTSLPALPSGL---KELIVSGNRLTSLPVLPS---ELKELM 408

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41281398  455 LEENKLESLPneiAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLpeeigTLENLEEL 522
Cdd:PRK15387 409 VSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSER-----TLQALREI 468
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
105-296 1.25e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 64.33  E-value: 1.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  105 LDLSKRSIHILPSSIKelTQLTELYLYSNKLQSLPAEVGclVNLMTLALSENSLTSLPDSLDnlKKLRMLDLRHNKLREI 184
Cdd:PRK15370 288 LSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVL 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  185 PSVVyrLDSLTTLYLRFNRITTVEKDIKnlSKLSMLSIRENKIKQLPaeigelcnlitldvahnqlEHLPKEIGNCTQIT 264
Cdd:PRK15370 362 PETL--PPTITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLP-------------------ESLPHFRGEGPQPT 418

                        170       180       190
                 ....*....|....*....|....*....|...
gi 41281398  265 NLDLQHNELLDlpDTIGNLSSL-SRLGLRYNRL 296
Cdd:PRK15370 419 RIIVEYNPFSE--RTIQNMQRLmSSVGYQGPRV 449
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
243-528 4.02e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 62.87  E-value: 4.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  243 LDVAHNQLEHLPkeigNC--TQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSaleELNLENNNIS 320
Cdd:PRK15387 206 LNVGESGLTTLP----DClpAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELS---IFSNPLTHLP 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  321 TLPESLLSSLVKLNSLTLarncfqlYPVGGPSqfstIYSLNMEHNRINKIPfgifSRAKVLSKLNMKDNQLTSLPLdfgT 400
Cdd:PRK15387 279 ALPSGLCKLWIFGNQLTS-------LPVLPPG----LQELSVSDNQLASLP----ALPSELCKLWAYNNQLTSLPT---L 340

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  401 WTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLgnlrklRELDLEENKLESLPneiAYLKDLQKLVLTN 480
Cdd:PRK15387 341 PSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGL------KELIVSGNRLTSLP---VLPSELKELMVSG 411

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 41281398  481 NQLTTLPRgigHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNP 528
Cdd:PRK15387 412 NRLTSLPM---LPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNP 456
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
381-557 4.05e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 59.41  E-value: 4.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  381 LSKLNMKDNQLTSLPLdfgTWTSMVELNLATNQLTKIPEDVSGLVSLevLILSNNL--LKKLPHGlgnlrkLRELDLEEN 458
Cdd:PRK15387 244 LRTLEVSGNQLTSLPV---LPPGLLELSIFSNPLTHLPALPSGLCKL--WIFGNQLtsLPVLPPG------LQELSVSDN 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  459 KLESLPneiAYLKDLQKLVLTNNQLTTLPRgigHLTNLTHLGLGENLLTHLPeeigTL-ENLEELYLNDNpNLHSLPfel 537
Cdd:PRK15387 313 QLASLP---ALPSELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLP----TLpSELYKLWAYNN-RLTSLP--- 378

                        170       180
                 ....*....|....*....|
gi 41281398  538 ALCSKLSIMSIENCPLSHLP 557
Cdd:PRK15387 379 ALPSGLKELIVSGNRLTSLP 398
LRR_8 pfam13855
Leucine rich repeat;
123-181 5.38e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 5.38e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41281398   123 TQLTELYLYSNKLQSLPAEV-GCLVNLMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKL 181
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
147-204 2.27e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.27e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398   147 NLMTLALSENSLTSL-PDSLDNLKKLRMLDLRHNKLREIPSVV-YRLDSLTTLYLRFNRI 204
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 383-528 4.08e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 4.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTK----IPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLR-KLRE 452
Cdd:cd00116  62 ETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPdgcgVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPpALEK 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 453 LDLEENKL-----ESLPNEIAYLKDLQKLVLTNNQL-----TTLPRGIGHLTNLTHLGLGENLLTH-----LPEEIGTLE 517
Cdd:cd00116 142 LVLGRNRLegascEALAKALRANRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTDegasaLAETLASLK 221

                       170
                ....*....|.
gi 41281398 518 NLEELYLNDNP 528
Cdd:cd00116 222 SLEVLNLGDNN 232
PLN03150 PLN03150
hypothetical protein; Provisional
 229-303 9.00e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 9.00e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41281398  229 QLPAEIGELCNLITLDVAHNQLE-HLPKEIGNCTQITNLDLQHNELL-DLPDTIGNLSSLSRLGLRYNRLSA-IPRSL 303
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGrVPAAL 510
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 115-289 9.54e-07

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 52.18  E-value: 9.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398   115 LPSSIKELTQLTELYL-YSNKLQSLPAEV-----------GCL---------VNLMTLALSENSLTSLPDS--LDNLKKL 171
Cdd:PLN03210  673 LPSSIQYLNKLEDLDMsRCENLEILPTGInlkslyrlnlsGCSrlksfpdisTNISWLDLDETAIEEFPSNlrLENLDEL 752

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398   172 RMLDLRHNKLRE-----IPSVVYRLDSLTTLYLRFN-RITTVEKDIKNLSKLSMLSIRENK-IKQLPAEIgELCNLITLD 244
Cdd:PLN03210  753 ILCEMKSEKLWErvqplTPLMTMLSPSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENCInLETLPTGI-NLESLESLD 831

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 41281398   245 VAH-NQLEHLPkEIGncTQITNLDLQHNELLDLPDTIGNLSSLSRL 289
Cdd:PLN03210  832 LSGcSRLRTFP-DIS--TNISDLNLSRTGIEEVPWWIEKFSNLSFL 874
LRR_8 pfam13855
Leucine rich repeat;
426-483 1.75e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.75e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398   426 SLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQL 483
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 377-560 3.39e-06

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 50.26  E-value: 3.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398   377 RAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL-ATNQLTKIPeDVSGLVSLEVLILSN-NLLKKLPHGLGNLRKLRELD 454
Cdd:PLN03210  609 RPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLrGSKNLKEIP-DLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLD 687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398   455 LEE-NKLESLPNEI-------------AYLK-------DLQKLVLTNNQLTTLPRGIgHLTNLTHLGLGENLLTHLPEEI 513
Cdd:PLN03210  688 MSRcENLEILPTGInlkslyrlnlsgcSRLKsfpdistNISWLDLDETAIEEFPSNL-RLENLDELILCEMKSEKLWERV 766

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 41281398   514 GTL--------ENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCP-LSHLPPQI 560
Cdd:PLN03210  767 QPLtplmtmlsPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCInLETLPTGI 822
LRR_8 pfam13855
Leucine rich repeat;
473-528 1.37e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 41281398   473 LQKLVLTNNQLTTLPRGI-GHLTNLTHLGLGENLLTHL-PEEIGTLENLEELYLNDNP 528
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
402-460 1.54e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.54e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41281398   402 TSMVELNLATNQLTKIPEDV-SGLVSLEVLILSNNLLKKL-PHGLGNLRKLRELDLEENKL 460
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 214-458 1.63e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 1.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 214 LSKLSMLSIRENKIKQLPaEIGELCNLITLDVAHNQLEHLPKeIGNCTQITNLDLQHNELLDLPDtIGNLSSLSRLGLRY 293
Cdd:cd21340   1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 294 NRLSAIprslakcsaleelnlennnistlpeSLLSSLVKLNSLTLARncfQLYPVGGPSQFStiyslnmehnrinkiPFG 373
Cdd:cd21340  78 NRISVV-------------------------EGLENLTNLEELHIEN---QRLPPGEKLTFD---------------PRS 114

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 374 IFSRAKVLSKLNMKDNQLTSLpldfgtwtsmvelnlatnqltkipEDVSGLVSLEVLILSNNLL---KKLPHGLGNLRKL 450
Cdd:cd21340 115 LAALSNSLRVLNISGNNIDSL------------------------EPLAPLRNLEQLDASNNQIsdlEELLDLLSSWPSL 170


                ....*...
gi 41281398 451 RELDLEEN 458
Cdd:cd21340 171 RELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 417-491 1.65e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 1.65e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41281398  417 IPEDVSGLVSLEVLILSNNLLK-KLPHGLGNLRKLRELDLEENKLE-SLPNEIAYLKDLQKLVLTNNQLT-TLPRGIG 491
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 453-527 1.89e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 1.89e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41281398  453 LDLEENKLES-LPNEIAYLKDLQKLVLTNNQLT-TLPRGIGHLTNLTHLGLGENLLT-HLPEEIGTLENLEELYLNDN 527
Cdd:PLN03150 423 LGLDNQGLRGfIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
448-506 2.70e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.70e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41281398   448 RKLRELDLEENKLESLPNEIAY-LKDLQKLVLTNNQLTTL-PRGIGHLTNLTHLGLGENLL 506
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 115-188 6.59e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.96  E-value: 6.59e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41281398  115 LPSSIKELTQLTELYLYSNKLQ-SLPAEVGCLVNLMTLALSENSLT-SLPDSLDNLKKLRMLDLRHNKLR-EIPSVV 188
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 260-507 7.52e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 7.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 260 CTQITNLD---LQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSaleelnlennnistlpeSLLSSLVKLNSL 336
Cdd:cd00116  24 CLQVLRLEgntLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLL-----------------QGLTKGCGLQEL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 337 TLARNCFQLYPVGGPSQFSTIYSL---NMEHNRINKIPF-----GIFSRAKVLSKLNMKDNQLTS-----LPLDFGTWTS 403
Cdd:cd00116  87 DLSDNALGPDGCGVLESLLRSSSLqelKLNNNGLGDRGLrllakGLKDLPPALEKLVLGRNRLEGasceaLAKALRANRD 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398 404 MVELNLATNQL-----TKIPEDVSGLVSLEVLILSNNLL-----KKLPHGLGNLRKLRELDLEENKLESLPneIAYLKD- 472
Cdd:cd00116 167 LKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLTDAG--AAALASa 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 41281398 473 -------LQKLVLTNNQLT-----TLPRGIGHLTNLTHLGLGENLLT 507
Cdd:cd00116 245 llspnisLLTLSLSCNDITddgakDLAEVLAEKESLLELDLRGNKFG 291
LRR_8 pfam13855
Leucine rich repeat;
193-250 1.06e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.06e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398   193 SLTTLYLRFNRITTVEKDI-KNLSKLSMLSIRENKIKQL-PAEIGELCNLITLDVAHNQL 250
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 376-445 2.20e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 2.20e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41281398  376 SRAKVLSKLNMKDNQLT-SLPLDFGTWTSMVELNLATNQLT-KIPEDVSGLVSLEVLILSNNLLK-KLPHGLG 445
Cdd:PLN03150 439 SKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
LRR_8 pfam13855
Leucine rich repeat;
170-227 5.69e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 5.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398   170 KLRMLDLRHNKLREI-PSVVYRLDSLTTLYLRFNRITTVEKD-IKNLSKLSMLSIRENKI 227
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
111-224 9.47e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 9.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281398  111 SIHILPSSIKELT--------------QLTELYLYSNKLQSLPAEVGCLVNLMtlaLSENSLTSLPDSLDNLKKLRMLDL 176
Cdd:PRK15387 336 SLPTLPSGLQELSvsdnqlaslptlpsELYKLWAYNNRLTSLPALPSGLKELI---VSGNRLTSLPVLPSELKELMVSGN 412

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 41281398  177 RHNKLREIPS-----VVYR--LDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224
Cdd:PRK15387 413 RLTSLPMLPSgllslSVYRnqLTRLPESLIHLSSETTVNLEGNPLSERTLQALRE 467
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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