NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6325435|ref|NP_015504|]
View 

U4/U6-U5 snRNP complex subunit PRP4 [Saccharomyces cerevisiae S288C]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-465 1.67e-67

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 217.59  E-value: 1.67e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQkLDSHVGKIGAIDWHPDSNnQMISCAEDGLIKNFQYSNEEgg 254
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETGE-- 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  255 lrLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLW 334
Cdd:cd00200  85 --CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  335 DIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDegQLNQILAHRNIVTQVRFSkeDGGKKLVSCG 414
Cdd:cd00200 163 DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK--CLGTLRGHENGVNSVAFS--PDGYLLASGS 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 6325435  415 YDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465
Cdd:cd00200 239 EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
HIP1_clath_bdg super family cl23867
Clathrin-binding domain of Huntingtin-interacting protein 1; HIP1_clath_bdg is the coiled-coil ...
 128-175 1.75e-03

Clathrin-binding domain of Huntingtin-interacting protein 1; HIP1_clath_bdg is the coiled-coil region of Huntington-interacting proteins 1. It carries a highly conserved HADLLRKN sequence motif at its N-terminus which effects the binding of HIP1R to clathrin light-chain EED regulatory site. this binding then stimulates clathrin lattice assembly. Huntingtin-interacting protein 1 (HIP1) is an obligate binding partner for Huntungtin, and loss of this interaction triggers the cascade of events that results in the apoptosis of neuronal cells and the onset of Hungtinton's disease. Clathrin light-chain binds to a flexible coiled-coil domain in HIP1 and induces a compact state that is refractory to actin binding.


The actual alignment was detected with superfamily member pfam16515:

Pssm-ID: 465154 [Multi-domain]  Cd Length: 99  Bit Score: 37.68  E-value: 1.75e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6325435    128 SLERSRKRLQKEMER----------HQKFNT---RQELLSRRTELQR----MANLELAGSQLVST 175
Cdd:pfam16515  24 EVEREKKQLEFELERakeeaqmkleEQKEELerlKRELESSRAELATlqstLQSSEQSGSQLSSQ 88
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-465 1.67e-67

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 217.59  E-value: 1.67e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQkLDSHVGKIGAIDWHPDSNnQMISCAEDGLIKNFQYSNEEgg 254
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETGE-- 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  255 lrLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLW 334
Cdd:cd00200  85 --CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  335 DIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDegQLNQILAHRNIVTQVRFSkeDGGKKLVSCG 414
Cdd:cd00200 163 DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK--CLGTLRGHENGVNSVAFS--PDGYLLASGS 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 6325435  415 YDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465
Cdd:cd00200 239 EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
175-465 1.93e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 210.92  E-value: 1.93e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLtQKLDSHVGKIGAIDWHPDSNnQMISCAEDGLIKNFQYSNeegg 254
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLAT---- 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  255 LRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLW 334
Cdd:COG2319 194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  335 DIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEgqLNQILAHRNIVTQVRFSkeDGGKKLVSCG 414
Cdd:COG2319 274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVAFS--PDGKTLASGS 349

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 6325435  415 YDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465
Cdd:COG2319 350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 338-377 3.34e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 3.34e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6325435     338 SGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWD 377
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
339-377 1.00e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 1.00e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6325435    339 GSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWD 377
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 219-380 6.64e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.90  E-value: 6.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435   219 GKIGAIDWHPDSNNQMISCAEDGLIknFQYSNEEGGLRL-----LGDLVGHERRISDVKYHPSGK-FIGSASHDMTWRLW 292
Cdd:PTZ00421  76 GPIIDVAFNPFDPQKLFTASEDGTI--MGWGIPEEGLTQnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVW 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435   293 DASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGH-SKPIYTVAWSPNGYQVATGGGDG 371
Cdd:PTZ00421 154 DVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHaSAKSQRCLWAKRKDLIITLGCSK 233

                        170
                 ....*....|...
gi 6325435   372 I----INVWDIRK 380
Cdd:PTZ00421 234 SqqrqIMLWDTRK 246
HIP1_clath_bdg pfam16515
Clathrin-binding domain of Huntingtin-interacting protein 1; HIP1_clath_bdg is the coiled-coil ...
 128-175 1.75e-03

Clathrin-binding domain of Huntingtin-interacting protein 1; HIP1_clath_bdg is the coiled-coil region of Huntington-interacting proteins 1. It carries a highly conserved HADLLRKN sequence motif at its N-terminus which effects the binding of HIP1R to clathrin light-chain EED regulatory site. this binding then stimulates clathrin lattice assembly. Huntingtin-interacting protein 1 (HIP1) is an obligate binding partner for Huntungtin, and loss of this interaction triggers the cascade of events that results in the apoptosis of neuronal cells and the onset of Hungtinton's disease. Clathrin light-chain binds to a flexible coiled-coil domain in HIP1 and induces a compact state that is refractory to actin binding.


Pssm-ID: 465154 [Multi-domain]  Cd Length: 99  Bit Score: 37.68  E-value: 1.75e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6325435    128 SLERSRKRLQKEMER----------HQKFNT---RQELLSRRTELQR----MANLELAGSQLVST 175
Cdd:pfam16515  24 EVEREKKQLEFELERakeeaqmkleEQKEELerlKRELESSRAELATlqstLQSSEQSGSQLSSQ 88
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-465 1.67e-67

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 217.59  E-value: 1.67e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQkLDSHVGKIGAIDWHPDSNnQMISCAEDGLIKNFQYSNEEgg 254
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETGE-- 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  255 lrLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLW 334
Cdd:cd00200  85 --CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  335 DIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDegQLNQILAHRNIVTQVRFSkeDGGKKLVSCG 414
Cdd:cd00200 163 DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK--CLGTLRGHENGVNSVAFS--PDGYLLASGS 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 6325435  415 YDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465
Cdd:cd00200 239 EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
175-465 1.93e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 210.92  E-value: 1.93e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLtQKLDSHVGKIGAIDWHPDSNnQMISCAEDGLIKNFQYSNeegg 254
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLAT---- 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  255 LRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLW 334
Cdd:COG2319 194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  335 DIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEgqLNQILAHRNIVTQVRFSkeDGGKKLVSCG 414
Cdd:COG2319 274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVAFS--PDGKTLASGS 349

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 6325435  415 YDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465
Cdd:COG2319 350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
152-465 7.80e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 206.69  E-value: 7.80e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  152 LLSRRTELQRMANLELAGSQLVSTKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQkLDSHVGKIGAIDWHPDSN 231
Cdd:COG2319  55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT-LTGHTGAVRSVAFSPDGK 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  232 nQMISCAEDGLIKNFqysNEEGGlRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVF 311
Cdd:COG2319 134 -TLASGSADGTVRLW---DLATG-KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR 208

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  312 SLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIrkrDEGQLNQILA 391
Cdd:COG2319 209 SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL---ATGELLRTLT 285

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6325435  392 -HRNIVTQVRFSKEdgGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465
Cdd:COG2319 286 gHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 257-465 1.30e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.50  E-value: 1.30e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  257 LLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDI 336
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  337 RSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLnqILAHRNIVTQVRFSKedGGKKLVSCGYD 416
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT--LRGHTDWVNSVAFSP--DGTFVASSSQD 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 6325435  417 NLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 COG2319
WD40 repeat [General function prediction only];
254-465 1.75e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 1.75e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  254 GLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSML 333
Cdd:COG2319  25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRL 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  334 WDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIrkrDEGQLNQIL-AHRNIVTQVRFSKedGGKKLVS 412
Cdd:COG2319 105 WDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL---ATGKLLRTLtGHSGAVTSVAFSP--DGKLLAS 179

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 6325435  413 CGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465
Cdd:COG2319 180 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 COG2319
WD40 repeat [General function prediction only];
275-465 9.69e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.24  E-value: 9.69e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  275 PSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYT 354
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435  355 VAWSPNGYQVATGGGDGIINVWDIrkRDEGQLNQILAHRNIVTQVRFSkeDGGKKLVSCGYDNLINVYSSDTWLKMGSLA 434
Cdd:COG2319  84 VAFSPDGRLLASASADGTVRLWDL--ATGLLLRTLTGHTGAVRSVAFS--PDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190
                ....*....|....*....|....*....|.
gi 6325435  435 GHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 338-377 3.34e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 3.34e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6325435     338 SGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWD 377
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
339-377 1.00e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 1.00e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6325435    339 GSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWD 377
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 219-380 6.64e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.90  E-value: 6.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435   219 GKIGAIDWHPDSNNQMISCAEDGLIknFQYSNEEGGLRL-----LGDLVGHERRISDVKYHPSGK-FIGSASHDMTWRLW 292
Cdd:PTZ00421  76 GPIIDVAFNPFDPQKLFTASEDGTI--MGWGIPEEGLTQnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVW 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435   293 DASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGH-SKPIYTVAWSPNGYQVATGGGDG 371
Cdd:PTZ00421 154 DVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHaSAKSQRCLWAKRKDLIITLGCSK 233

                        170
                 ....*....|...
gi 6325435   372 I----INVWDIRK 380
Cdd:PTZ00421 234 SqqrqIMLWDTRK 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 426-465 1.37e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.37e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6325435     426 TWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
431-465 4.18e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 4.18e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 6325435    431 GSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 261-382 1.05e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.05  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435   261 LVGHERRISDVKYHP--SGKFIgSASHDMTWRLWD-------ASTHQELLLQEGHDKGVFSLSFQCDGSLV-CSGGMDSL 330
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfdPQKLF-TASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNVlASAGADMV 149

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6325435   331 SMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRD 382
Cdd:PTZ00421 150 VNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGT 201
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 280-447 1.16e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 1.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435   280 IGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSF-QCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWS 358
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435   359 PNGYQVATGGGDGIINVWDIRKrDEGQLNQILAHRNIVTQVRFSKEdggKKLVSCGYDNLINVY------SSDTWLKMGS 432
Cdd:PLN00181 628 ESGRSLAFGSADHKVYYYDLRN-PKLPLCTMIGHSKTVSYVRFVDS---STLVSSSTDNTLKLWdlsmsiSGINETPLHS 703

                        170
                 ....*....|....*..
gi 6325435   433 LAGHTD--KIISLDISN 447
Cdd:PLN00181 704 FMGHTNvkNFVGLSVSD 720
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 256-293 2.63e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.63e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 6325435     256 RLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWD 293
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
256-293 2.89e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.89e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 6325435    256 RLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWD 293
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 261-465 1.34e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435   261 LVGHERRISDVKYHPS-GKFIGSASHDMTWRLWDASTHQE--------LLLQEGHDKGVFSLSFQ-CDGSLVCSGGMDSL 330
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDEsvkeikdpQCILKGHKKKISIIDWNpMNYYIMCSSGFDSF 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435   331 SMLWDIRSGSKVMTLAgHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGqlNQILAHrnivtqvrfskeDGGKKl 410
Cdd:PTZ00420 150 VNIWDIENEKRAFQIN-MPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIA--SSFHIH------------DGGKN- 213

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 6325435   411 vscgydnlinvySSDTWLKmgSLAGHTDKIISLDISNNSHflvsggwdRSIKLWN 465
Cdd:PTZ00420 214 ------------TKNIWID--GLGGDDNYILSTGFSKNNM--------REMKLWD 246
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 259-465 1.56e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435   259 GDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASThqelLLQEGHD--------KGVFSLSFQCDGSL----VCSGG 326
Cdd:PLN00181 477 GDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECES----IIKDGRDihypvvelASRSKLSGICWNSYiksqVASSN 552

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435   327 MDSLSMLWDIRSGSKVMTLAGHSKPIYTVAW-SPNGYQVATGGGDGIINVWDIrkrDEG-QLNQILAHRNIVTqVRFSkE 404
Cdd:PLN00181 553 FEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSI---NQGvSIGTIKTKANICC-VQFP-S 627

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6325435   405 DGGKKLVSCGYDNLINVYS-SDTWLKMGSLAGHTdKIISLDISNNSHFLVSGGWDRSIKLWN 465
Cdd:PLN00181 628 ESGRSLAFGSADHKVYYYDlRNPKLPLCTMIGHS-KTVSYVRFVDSSTLVSSSTDNTLKLWD 688
WD40 pfam00400
WD domain, G-beta repeat;
304-335 7.51e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 7.51e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 6325435    304 EGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWD 335
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 202-322 9.08e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 9.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325435   202 LNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGD----LVGHERRISDVKYHPSG 277
Cdd:PTZ00420  58 LENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKEIKDpqciLKGHKKKISIIDWNPMN 137

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 6325435   278 KFI-GSASHDMTWRLWDASTHQElLLQEGHDKGVFSLSFQCDGSLV 322
Cdd:PTZ00420 138 YYImCSSGFDSFVNIWDIENEKR-AFQINMPKKLSSLKWNIKGNLL 182
HIP1_clath_bdg pfam16515
Clathrin-binding domain of Huntingtin-interacting protein 1; HIP1_clath_bdg is the coiled-coil ...
 128-175 1.75e-03

Clathrin-binding domain of Huntingtin-interacting protein 1; HIP1_clath_bdg is the coiled-coil region of Huntington-interacting proteins 1. It carries a highly conserved HADLLRKN sequence motif at its N-terminus which effects the binding of HIP1R to clathrin light-chain EED regulatory site. this binding then stimulates clathrin lattice assembly. Huntingtin-interacting protein 1 (HIP1) is an obligate binding partner for Huntungtin, and loss of this interaction triggers the cascade of events that results in the apoptosis of neuronal cells and the onset of Hungtinton's disease. Clathrin light-chain binds to a flexible coiled-coil domain in HIP1 and induces a compact state that is refractory to actin binding.


Pssm-ID: 465154 [Multi-domain]  Cd Length: 99  Bit Score: 37.68  E-value: 1.75e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6325435    128 SLERSRKRLQKEMER----------HQKFNT---RQELLSRRTELQR----MANLELAGSQLVST 175
Cdd:pfam16515  24 EVEREKKQLEFELERakeeaqmkleEQKEELerlKRELESSRAELATlqstLQSSEQSGSQLSSQ 88
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 296-335 1.90e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.90e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6325435     296 THQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWD 335
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH