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Conserved domains on  [gi|6324994|ref|NP_015063|]
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Cub1p [Saccharomyces cerevisiae S288C]

Protein Classification

DUF2408 domain-containing protein( domain architecture ID 10563344)

DUF2408 domain-containing protein similar to Saccharomyces cerevisiae Cu(2+) suppressing and bleomycin sensitive protein 1 (also known as UPF0662 protein YPL260W), which is involved in bleomycin tolerance with links to DNA repair and/or proteasome function

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF2408 pfam10303
Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The ...
 209-372 1.18e-50

Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The function is unknown.


:

Pssm-ID: 431205  Cd Length: 130  Bit Score: 170.05  E-value: 1.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324994    209 LEEIDPSLSTVMEKLFRIRRGLLSLVASAKKTMSKsdintnsllqeqndlqtnnesltddkhlvsqeyvhEKLSVLKNEL 288
Cdd:pfam10303   1 LEELPPELEPIYEKLVSIRRSLLSLATRSKFPSKA-----------------------------------KELKELKKEL 45

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324994    289 SELESNRDDSGKFKSLESHQVAEKGQSVLNGLLDDCHDLVNDLSHQKNGG-LTLDPYLQPIYEQLIDIKTTLENLMITRR 367
Cdd:pfam10303  46 KEIESKRDEDGKFASSEGGEVVPKGQAVLNGLLDDCFDLIEDLSAQDNGEqGKLDPKLQPIYDRLLDIKTTLENLLLTRR 125


                  ....*
gi 6324994    368 WTLRE 372
Cdd:pfam10303 126 WTLRE 130
DUF2408 super family cl10978
Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The ...
 341-443 1.53e-11

Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The function is unknown.


The actual alignment was detected with superfamily member pfam10303:

Pssm-ID: 431205  Cd Length: 130  Bit Score: 61.81  E-value: 1.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324994    341 LDPYLQPIYEQLIDIKTTLENLMITRRWTLRETDLFSYQKKLNEIDNKRI-NGKF---PTKSQDSKGQSILLYLLRRCYA 416
Cdd:pfam10303   4 LPPELEPIYEKLVSIRRSLLSLATRSKFPSKAKELKELKKELKEIESKRDeDGKFassEGGEVVPKGQAVLNGLLDDCFD 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 6324994    417 IIYKLLESSEP----VSEALQPIHNQLSTVR 443
Cdd:pfam10303  84 LIEDLSAQDNGeqgkLDPKLQPIYDRLLDIK 114
DUF2408 super family cl10978
Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The ...
 428-518 1.01e-06

Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The function is unknown.


The actual alignment was detected with superfamily member pfam10303:

Pssm-ID: 431205  Cd Length: 130  Bit Score: 47.94  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324994    428 VSEALQPIHNQLSTVRRCLLEL----KRMGGVNnerELYPYQMKLASLDNLRTE-GIFYDSDGNI--PEGQGILNALLAE 500
Cdd:pfam10303   4 LPPELEPIYEKLVSIRRSLLSLatrsKFPSKAK---ELKELKKELKEIESKRDEdGKFASSEGGEvvPKGQAVLNGLLDD 80

                          90
                  ....*....|....*...
gi 6324994    501 CFDILHELKVEAEEKAQN 518
Cdd:pfam10303  81 CFDLIEDLSAQDNGEQGK 98
 
Name Accession Description Interval E-value
DUF2408 pfam10303
Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The ...
 209-372 1.18e-50

Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The function is unknown.


Pssm-ID: 431205  Cd Length: 130  Bit Score: 170.05  E-value: 1.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324994    209 LEEIDPSLSTVMEKLFRIRRGLLSLVASAKKTMSKsdintnsllqeqndlqtnnesltddkhlvsqeyvhEKLSVLKNEL 288
Cdd:pfam10303   1 LEELPPELEPIYEKLVSIRRSLLSLATRSKFPSKA-----------------------------------KELKELKKEL 45

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324994    289 SELESNRDDSGKFKSLESHQVAEKGQSVLNGLLDDCHDLVNDLSHQKNGG-LTLDPYLQPIYEQLIDIKTTLENLMITRR 367
Cdd:pfam10303  46 KEIESKRDEDGKFASSEGGEVVPKGQAVLNGLLDDCFDLIEDLSAQDNGEqGKLDPKLQPIYDRLLDIKTTLENLLLTRR 125


                  ....*
gi 6324994    368 WTLRE 372
Cdd:pfam10303 126 WTLRE 130
DUF2408 pfam10303
Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The ...
 341-443 1.53e-11

Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The function is unknown.


Pssm-ID: 431205  Cd Length: 130  Bit Score: 61.81  E-value: 1.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324994    341 LDPYLQPIYEQLIDIKTTLENLMITRRWTLRETDLFSYQKKLNEIDNKRI-NGKF---PTKSQDSKGQSILLYLLRRCYA 416
Cdd:pfam10303   4 LPPELEPIYEKLVSIRRSLLSLATRSKFPSKAKELKELKKELKEIESKRDeDGKFassEGGEVVPKGQAVLNGLLDDCFD 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 6324994    417 IIYKLLESSEP----VSEALQPIHNQLSTVR 443
Cdd:pfam10303  84 LIEDLSAQDNGeqgkLDPKLQPIYDRLLDIK 114
DUF2408 pfam10303
Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The ...
 428-518 1.01e-06

Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The function is unknown.


Pssm-ID: 431205  Cd Length: 130  Bit Score: 47.94  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324994    428 VSEALQPIHNQLSTVRRCLLEL----KRMGGVNnerELYPYQMKLASLDNLRTE-GIFYDSDGNI--PEGQGILNALLAE 500
Cdd:pfam10303   4 LPPELEPIYEKLVSIRRSLLSLatrsKFPSKAK---ELKELKKELKEIESKRDEdGKFASSEGGEvvPKGQAVLNGLLDD 80

                          90
                  ....*....|....*...
gi 6324994    501 CFDILHELKVEAEEKAQN 518
Cdd:pfam10303  81 CFDLIEDLSAQDNGEQGK 98
 
Name Accession Description Interval E-value
DUF2408 pfam10303
Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The ...
 209-372 1.18e-50

Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The function is unknown.


Pssm-ID: 431205  Cd Length: 130  Bit Score: 170.05  E-value: 1.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324994    209 LEEIDPSLSTVMEKLFRIRRGLLSLVASAKKTMSKsdintnsllqeqndlqtnnesltddkhlvsqeyvhEKLSVLKNEL 288
Cdd:pfam10303   1 LEELPPELEPIYEKLVSIRRSLLSLATRSKFPSKA-----------------------------------KELKELKKEL 45

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324994    289 SELESNRDDSGKFKSLESHQVAEKGQSVLNGLLDDCHDLVNDLSHQKNGG-LTLDPYLQPIYEQLIDIKTTLENLMITRR 367
Cdd:pfam10303  46 KEIESKRDEDGKFASSEGGEVVPKGQAVLNGLLDDCFDLIEDLSAQDNGEqGKLDPKLQPIYDRLLDIKTTLENLLLTRR 125


                  ....*
gi 6324994    368 WTLRE 372
Cdd:pfam10303 126 WTLRE 130
DUF2408 pfam10303
Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The ...
 341-443 1.53e-11

Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The function is unknown.


Pssm-ID: 431205  Cd Length: 130  Bit Score: 61.81  E-value: 1.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324994    341 LDPYLQPIYEQLIDIKTTLENLMITRRWTLRETDLFSYQKKLNEIDNKRI-NGKF---PTKSQDSKGQSILLYLLRRCYA 416
Cdd:pfam10303   4 LPPELEPIYEKLVSIRRSLLSLATRSKFPSKAKELKELKKELKEIESKRDeDGKFassEGGEVVPKGQAVLNGLLDDCFD 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 6324994    417 IIYKLLESSEP----VSEALQPIHNQLSTVR 443
Cdd:pfam10303  84 LIEDLSAQDNGeqgkLDPKLQPIYDRLLDIK 114
DUF2408 pfam10303
Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The ...
 428-518 1.01e-06

Protein of unknown function (DUF2408); This is a family of proteins conserved in fungi. The function is unknown.


Pssm-ID: 431205  Cd Length: 130  Bit Score: 47.94  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324994    428 VSEALQPIHNQLSTVRRCLLEL----KRMGGVNnerELYPYQMKLASLDNLRTE-GIFYDSDGNI--PEGQGILNALLAE 500
Cdd:pfam10303   4 LPPELEPIYEKLVSIRRSLLSLatrsKFPSKAK---ELKELKKELKEIESKRDEdGKFASSEGGEvvPKGQAVLNGLLDD 80

                          90
                  ....*....|....*...
gi 6324994    501 CFDILHELKVEAEEKAQN 518
Cdd:pfam10303  81 CFDLIEDLSAQDNGEQGK 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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