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Conserved domains on  [gi|398365123|ref|NP_014334|]
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Aqr1p [Saccharomyces cerevisiae S288C]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 103-553 3.14e-112

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 339.94  E-value: 3.14e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 103 VAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIG 182
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 183 LACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLT 262
Cdd:cd17323   81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 263 IGCGSCFLIAFLIlpetkrtiagnlsikpkrfinrapifllgpvrrrfkydnpdyetldptipkldlssagkilvLPEII 342
Cdd:cd17323  161 IISGFCLILIFLF--------------------------------------------------------------LPIVL 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 343 LSLFPSGLLFAMWTLMLSSISSGLSVaPYNYHLVIIGVCYLPGGIGGLMGSFFTGRIIDMYFKRKIKKfeqdkanglipq 422
Cdd:cd17323  179 LLGLYVGLVYAILYLFLTAFPYVFGE-VYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKK------------ 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 423 DAEINMFKVRLVCLLPQNFLAVVAYLLFGWSIDKGWRIESILITSFVCSYCAMSTLSTSTTLLVDLYPTKSSTASSCFNF 502
Cdd:cd17323  246 NGGKPEPEARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTL 325

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 398365123 503 VRCSLSTIFMGCFAKMKAAMTVGGTFTFLCALVFFFNFLMFIPMKYGMKWR 553
Cdd:cd17323  326 VRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 103-553 3.14e-112

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 339.94  E-value: 3.14e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 103 VAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIG 182
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 183 LACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLT 262
Cdd:cd17323   81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 263 IGCGSCFLIAFLIlpetkrtiagnlsikpkrfinrapifllgpvrrrfkydnpdyetldptipkldlssagkilvLPEII 342
Cdd:cd17323  161 IISGFCLILIFLF--------------------------------------------------------------LPIVL 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 343 LSLFPSGLLFAMWTLMLSSISSGLSVaPYNYHLVIIGVCYLPGGIGGLMGSFFTGRIIDMYFKRKIKKfeqdkanglipq 422
Cdd:cd17323  179 LLGLYVGLVYAILYLFLTAFPYVFGE-VYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKK------------ 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 423 DAEINMFKVRLVCLLPQNFLAVVAYLLFGWSIDKGWRIESILITSFVCSYCAMSTLSTSTTLLVDLYPTKSSTASSCFNF 502
Cdd:cd17323  246 NGGKPEPEARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTL 325

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 398365123 503 VRCSLSTIFMGCFAKMKAAMTVGGTFTFLCALVFFFNFLMFIPMKYGMKWR 553
Cdd:cd17323  326 VRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
98-408 1.39e-36

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 139.72  E-value: 1.39e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  98 QKWGMVAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYV 177
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 178 IASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAI 257
Cdd:COG2814   87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 258 FWFLTIGCGSCFLIAFLILPETKRTIAGNLSIKPKRFINRAPIFLLgpvrrrfkydnpdyetldptipkldlssagkilv 337
Cdd:COG2814  167 FLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLL---------------------------------- 212

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398365123 338 lpeIILSLFPSGLLFAMWTLMlssisSGLSVAPYNYHLVIIGVCYLPGGIGGLMGSFFTGRIIDMYFKRKI 408
Cdd:COG2814  213 ---LLLAFLLGFGFFALFTYL-----PLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL 275
MFS_1 pfam07690
Major Facilitator Superfamily;
106-411 2.36e-26

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 110.20  E-value: 2.36e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  106 LTMCGFWSSLGSPIYYPAL-RQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLA 184
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  185 CAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIG 264
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  265 CGSCFLIAFLILPETKRTiagnlSIKPKRFINRAPIFLLGPVRRRfkydnpdyetldptipkldlssagkilVLPEIILS 344
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESK-----RPKPAEEARLSLIVAWKALLRD---------------------------PVLWLLLA 208

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 398365123  345 LFPSGLLFAMWTLMLSSISSGlsvapYNYHLVIIGVCYLPGGIGGLMGSFFTGRIIDMYFKRKIKKF 411
Cdd:pfam07690 209 LLLFGFAFFGLLTYLPLYQEV-----LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
2_A_01_02 TIGR00880
Multidrug resistance protein;
144-279 3.05e-24

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 98.49  E-value: 3.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  144 VYLLFQGISPTV----SGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTL 219
Cdd:TIGR00880   2 LLLAGYALGQLIysplSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  220 KHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLILPET 279
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
emrD PRK11652
multidrug transporter EmrD;
102-279 3.92e-21

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 95.74  E-value: 3.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 102 MVAILTMCGfwsSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASI 181
Cdd:PRK11652  12 MLVLLVAVG---QMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 182 GLACAPSYGVIIFLRCIQSIGIsptiaissGVVGDFTLKHERGTFVGAT----SGFVLLGQCFGSL----IGAVLTARWD 253
Cdd:PRK11652  89 VALFAHSLTVLIAASAIQGLGT--------GVGGVMARTLPRDLYEGTQlrhaNSLLNMGILVSPLlaplIGGLLTTLFG 160

                        170       180
                 ....*....|....*....|....*.
gi 398365123 254 WRAIFWFLTIGCGSCFLIAFLILPET 279
Cdd:PRK11652 161 WRACYLFLLLLGAGVTFSMARWMPET 186
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 103-553 3.14e-112

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 339.94  E-value: 3.14e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 103 VAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIG 182
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 183 LACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLT 262
Cdd:cd17323   81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 263 IGCGSCFLIAFLIlpetkrtiagnlsikpkrfinrapifllgpvrrrfkydnpdyetldptipkldlssagkilvLPEII 342
Cdd:cd17323  161 IISGFCLILIFLF--------------------------------------------------------------LPIVL 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 343 LSLFPSGLLFAMWTLMLSSISSGLSVaPYNYHLVIIGVCYLPGGIGGLMGSFFTGRIIDMYFKRKIKKfeqdkanglipq 422
Cdd:cd17323  179 LLGLYVGLVYAILYLFLTAFPYVFGE-VYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKK------------ 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 423 DAEINMFKVRLVCLLPQNFLAVVAYLLFGWSIDKGWRIESILITSFVCSYCAMSTLSTSTTLLVDLYPTKSSTASSCFNF 502
Cdd:cd17323  246 NGGKPEPEARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTL 325

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 398365123 503 VRCSLSTIFMGCFAKMKAAMTVGGTFTFLCALVFFFNFLMFIPMKYGMKWR 553
Cdd:cd17323  326 VRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
98-408 1.39e-36

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 139.72  E-value: 1.39e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  98 QKWGMVAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYV 177
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 178 IASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAI 257
Cdd:COG2814   87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 258 FWFLTIGCGSCFLIAFLILPETKRTIAGNLSIKPKRFINRAPIFLLgpvrrrfkydnpdyetldptipkldlssagkilv 337
Cdd:COG2814  167 FLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLL---------------------------------- 212

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398365123 338 lpeIILSLFPSGLLFAMWTLMlssisSGLSVAPYNYHLVIIGVCYLPGGIGGLMGSFFTGRIIDMYFKRKI 408
Cdd:COG2814  213 ---LLLAFLLGFGFFALFTYL-----PLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL 275
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 99-394 3.34e-32

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 126.08  E-value: 3.34e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  99 KWGMVAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVI 178
Cdd:COG0477   12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 179 ASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIF 258
Cdd:COG0477   92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 259 WFLTIGCGSCFLIAFLiLPETKRTIAGNLSIKPKRFINRAPIFLLGPVRRRFkydnpdyetldPTIPKLDLSSAGKILVL 338
Cdd:COG0477  172 LINAPLGLLALVLRLR-LPESRGLLLALLALALAALLLAALALALLALLLLL-----------LLLLLALLALLLAGAAL 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 398365123 339 PEIILSLFPSGLLFAMWTLMLSSISSGLSVAPYNYHLVIIGVCYLPGGIGGLMGSF 394
Cdd:COG0477  240 LLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 102-536 1.13e-31

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 126.54  E-value: 1.13e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 102 MVAILTMCGFwssLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASI 181
Cdd:cd17320    3 LLALLVALGP---LAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 182 GLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFL 261
Cdd:cd17320   80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 262 TIGCGSCFLIAFLILPETKrtiagnlsikpkrfinrapifllgPVRRRfkydnpdyetldPTIPKLDLSSAGKILVLPEI 341
Cdd:cd17320  160 ALLGLLLLLLVLLFLPETL------------------------PEEKR------------KPLLSSLLRAYKRVLKNRRF 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 342 ILSLFPSGLLFAMWtLMLSSISSGLSVAPYNYHLVIIGVCYLPGGIGGLMGSFFTGRIidmyfkrkIKKFEQDKanglip 421
Cdd:cd17320  204 LGYALALGLSFAGL-FAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRL--------VRRFGPRR------ 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 422 qdaeinMFKVRLVCLLpqnflaVVAYLLFGWSIDKGWRIESILITSFVCSYCAMSTLSTSTTLLVDLYPTKSSTASSCFN 501
Cdd:cd17320  269 ------LLRLGLLLLL------AAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLG 336

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 398365123 502 FVRCSLSTIFMGCFAK--------MKAAMTVGGTFTFLCALVF 536
Cdd:cd17320  337 FLQFLIGALAGALVGLlpngtalpMGLLILVLGLLALLLLILL 379
MFS_1 pfam07690
Major Facilitator Superfamily;
106-411 2.36e-26

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 110.20  E-value: 2.36e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  106 LTMCGFWSSLGSPIYYPAL-RQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLA 184
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  185 CAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIG 264
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  265 CGSCFLIAFLILPETKRTiagnlSIKPKRFINRAPIFLLGPVRRRfkydnpdyetldptipkldlssagkilVLPEIILS 344
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESK-----RPKPAEEARLSLIVAWKALLRD---------------------------PVLWLLLA 208

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 398365123  345 LFPSGLLFAMWTLMLSSISSGlsvapYNYHLVIIGVCYLPGGIGGLMGSFFTGRIIDMYFKRKIKKF 411
Cdd:pfam07690 209 LLLFGFAFFGLLTYLPLYQEV-----LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 103-304 1.12e-25

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 108.81  E-value: 1.12e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 103 VAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIG 182
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 183 LACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTArWDWRAIFWFLT 262
Cdd:cd17474   81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLA 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 398365123 263 IGCGSCFLIAFLILPETKRT---IAGNLSIKPKRFINRAPIFLLG 304
Cdd:cd17474  160 ALIPVAFLAILFLLPEPKEKaksSSATKLRDLKKALRGRGLLTFL 204
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 106-544 6.97e-25

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 106.74  E-value: 6.97e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 106 LTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLAC 185
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 186 APSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTAR--WDWRAIFWFLTI 263
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 264 GCGSCFLIAFLILPETKRTIAGNLSIKPKRFInrapiflLGPVRRRFKydnpdyetlDPTIPKLDLSsagkilvlpeIIL 343
Cdd:cd06174  161 LALLAAILLLLVVPDPPESARAKNEEASSKSV-------LKLLKRVLK---------NPGLWLLLLA----------IFL 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 344 SLFPSGLLFAMWTLMLSSIsSGLSVAPYNYHLVIIGVCylpggigGLMGSFFTGRIIDMYFKRkikkfeqdkanglipqd 423
Cdd:cd06174  215 VNLAYYSFSTLLPLFLLDL-GGLSVAVAGLLLSLFGLA-------GALGSLLLGLLSDRLIGR----------------- 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 424 aeinmfKVRLVCLLpqnFLAVVAYLLFGWSIDKGWRIESILITSFVcsyCAMSTLSTSTTLLVDLYPTKSSTASSCFNFV 503
Cdd:cd06174  270 ------KPLLLIGL---LLMALGLALLLLAPSLLLLLLLLLLLGFG---LGGLLPLSFALIAELFPPEIRGTAFGLLNTF 337

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 398365123 504 RCSLSTIFMGCFAKMKAAMTVGGTFTFLCALVFFFNFLMFI 544
Cdd:cd06174  338 GFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 106-408 2.01e-24

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 105.35  E-value: 2.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 106 LTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLAC 185
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 186 APSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGC 265
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 266 GSCFLIAFLILPETKRTIAGNlsiKPKRFINRAPIFLLGPVRRrfkydnpdyetldptipkldlssagKILVLPEIILSL 345
Cdd:cd17325  161 LLALVLALLLLPEPRPPPNKR---AVSAARLRSGLRLLLRDRR-------------------------LLALFLAIFVLA 212

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365123 346 FPSGLLFAMWTLMLSSIssglsvapYNYHLVIIGVCYLPGGIGGLMGSFFTGRIIDMYFKRKI 408
Cdd:cd17325  213 FAFGALEPFLPLYAAEL--------GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPL 267
2_A_01_02 TIGR00880
Multidrug resistance protein;
144-279 3.05e-24

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 98.49  E-value: 3.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  144 VYLLFQGISPTV----SGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTL 219
Cdd:TIGR00880   2 LLLAGYALGQLIysplSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  220 KHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLILPET 279
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 105-408 1.60e-22

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 99.55  E-value: 1.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 105 ILTMCGFwsSLGSPIYYPA--LRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIG 182
Cdd:cd17324    3 ALALAAF--AIGTTEYVIQglLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 183 LACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLT 262
Cdd:cd17324   81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 263 IGCGSCFLIAFLILPETKRTIAGNLSIkpkrfinrapifllgpvrrrfkydnpdyetldptipkldLSSAGKILVLPEII 342
Cdd:cd17324  161 VLALLAALLLWRLLPSLPPKKPGSLGL---------------------------------------LSSLLLLLRNPRLR 201

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398365123 343 LSLFPSGLLFAMWTLMLSSISSGLSVAPYNYHLVIIGVCYLpGGIGGLMGSFFTGRIIDMYFKRKI 408
Cdd:cd17324  202 LAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLL-FGVAGVVGSPLAGRLADRGGRRAL 266
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 102-280 3.66e-22

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 98.61  E-value: 3.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  102 MVAILTMCGFwssLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASI 181
Cdd:TIGR00710   9 LLGCLSILGP---LGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  182 GLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFL 261
Cdd:TIGR00710  86 GLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFL 165

                         170
                  ....*....|....*....
gi 398365123  262 TIGCGSCFLIAFLILPETK 280
Cdd:TIGR00710 166 SLAGILLSALIFFILPETL 184
emrD PRK11652
multidrug transporter EmrD;
102-279 3.92e-21

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 95.74  E-value: 3.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 102 MVAILTMCGfwsSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASI 181
Cdd:PRK11652  12 MLVLLVAVG---QMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 182 GLACAPSYGVIIFLRCIQSIGIsptiaissGVVGDFTLKHERGTFVGAT----SGFVLLGQCFGSL----IGAVLTARWD 253
Cdd:PRK11652  89 VALFAHSLTVLIAASAIQGLGT--------GVGGVMARTLPRDLYEGTQlrhaNSLLNMGILVSPLlaplIGGLLTTLFG 160

                        170       180
                 ....*....|....*....|....*.
gi 398365123 254 WRAIFWFLTIGCGSCFLIAFLILPET 279
Cdd:PRK11652 161 WRACYLFLLLLGAGVTFSMARWMPET 186
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 123-289 1.58e-20

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 93.39  E-value: 1.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 123 ALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIG 202
Cdd:cd17321   18 ALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 203 ISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIgcgscflIAFLILPETKRT 282
Cdd:cd17321   98 AAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVP-------IGLVALLLARTF 170


                 ....*..
gi 398365123 283 IAGNLSI 289
Cdd:cd17321  171 SGAVLAA 177
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 106-277 5.10e-20

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 91.87  E-value: 5.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 106 LTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLAC 185
Cdd:cd17504    1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 186 APSYGVIIFLRCIQSIGIsPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGC 265
Cdd:cd17504   81 APNLPVLIAGRALQGIGG-AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159

                        170
                 ....*....|..
gi 398365123 266 gscfLIAFLILP 277
Cdd:cd17504  160 ----VLLAALVP 167
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
99-276 7.68e-20

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 91.47  E-value: 7.68e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  99 KWGMVAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVI 178
Cdd:COG2271    8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 179 ASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIF 258
Cdd:COG2271   88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167

                        170
                 ....*....|....*...
gi 398365123 259 WFLTIGCGSCFLIAFLIL 276
Cdd:COG2271  168 LILGLPGLLLALLRFWLL 185
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
100-279 1.26e-17

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 84.93  E-value: 1.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 100 WGMVAILTMCGFWSSLGspiyyPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIA 179
Cdd:COG2223    9 LATLAFFLAFGVWYLWS-----VLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 180 SIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFW 259
Cdd:COG2223   84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163

                        170       180
                 ....*....|....*....|
gi 398365123 260 FLTIGCGSCFLIAFLILPET 279
Cdd:COG2223  164 ILGILLLVVAVLAWLFLRDP 183
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 142-277 3.20e-16

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 80.30  E-value: 3.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 142 VVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKH 221
Cdd:cd17502   36 GTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPR 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 398365123 222 ERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWF-LTIGcgscfLIAFLILP 277
Cdd:cd17502  116 ERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYInLPIG-----GLALALLR 167
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 122-408 4.29e-16

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 80.31  E-value: 4.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 122 PALRQLEKQF-NVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQS 200
Cdd:cd17473   20 PALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 201 IGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTArWDWRAIFWFltigcgscFLIAFLILPetk 280
Cdd:cd17473  100 IGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLV--------YLLALPVLI--- 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 281 rtiagnLSIkpkrfinrapIFLLGPVRRRFKYDNPDYETLDPTIPKLdlssagkilVLPeIILSLFPSGLLFAMWTLMLS 360
Cdd:cd17473  168 ------LVL----------LFLPEPARKSKSAASPGAATAAALPWKR---------VLP-IYFLAFLAMLLFYVIPIQLP 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 398365123 361 SISSGLSVAPYNYHLVIIGVcylpGGIGGLMGSFFTGRIIDMYFKRKI 408
Cdd:cd17473  222 FLLQERGGGSAALIGLALAI----ASLAGAIGALLFGRLKRRLGKRRL 265
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 144-394 1.95e-15

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 78.03  E-value: 1.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 144 VYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHER 223
Cdd:cd17316   44 AGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRR 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 224 GTFVGATSGFVLLGQCFGSLIGAVL----TARWDWRAIFWFLTIGCgscfLIAFLILPETKRTIAGNLSIkpkrFINRAP 299
Cdd:cd17316  124 GFALGLLQSGWALGALLAALVASLLipllSGDWGWRILFLIGALPA----LLALLLRRRTLLLILLWFFI----SFGYYG 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 300 IFLLGPvrrrfkydnpdyeTLDPTIPKLDLSSAGKILVLpeIILSLFPSGLLFAM--------WTLMLSSISSGLSVAPY 371
Cdd:cd17316  196 LTTFLP-------------TYLQTVLGLSPATSSLYLLL--ISLGALVGALIAGLlsdrigrkKTLVIGLILSGILALPL 260

                        250       260
                 ....*....|....*....|....*....
gi 398365123 372 ------NYHLVIIGVCYLPGGIGGLMGSF 394
Cdd:cd17316  261 fyllsgSPTLLLLLLFILSFFVGGVWGAL 289
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
120-279 1.33e-14

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 75.72  E-value: 1.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 120 YYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQ 199
Cdd:PRK11102  10 YLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLH 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 200 SIGISPTIAISSGVVGDFTLKHErgtFVGATSgFVLLGQCFGSL----IGAVLTARWDWRAIFWFLTI-GCGSCFLIAFL 274
Cdd:PRK11102  90 GLAAAAASVVINALMRDMFPKEE---FSRMMS-FVTLVMTIAPLlapiIGGWLLVWFSWHAIFWVLALaAILAAALVFFF 165


                 ....*
gi 398365123 275 IlPET 279
Cdd:PRK11102 166 I-PET 169
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 106-274 7.73e-14

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 73.38  E-value: 7.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 106 LTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLAC 185
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 186 APSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWF-LTIG 264
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYInLPIG 160

                        170
                 ....*....|
gi 398365123 265 CGSCFLIAFL 274
Cdd:cd17503  161 ILALLLAPLL 170
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
100-281 2.10e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 71.82  E-value: 2.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 100 WGMVAILTMCGFWSSLGSPIY-----YPALrqLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRR--PIILAG 172
Cdd:COG2271  177 LALLRFWLLALAYFLVYFALYgfltwLPTY--LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIG 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 173 MLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARW 252
Cdd:COG2271  255 LLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334

                        170       180
                 ....*....|....*....|....*....
gi 398365123 253 DWRAIFWFLTIGCGSCFLIAFLILPETKR 281
Cdd:COG2271  335 GYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 102-276 1.26e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 69.53  E-value: 1.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 102 MVAILTMCGFWSSLGS--PIYypalrqLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIA 179
Cdd:cd17325  205 FLAIFVLAFAFGALEPflPLY------AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 180 SIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFW 259
Cdd:cd17325  279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358

                        170
                 ....*....|....*..
gi 398365123 260 FLTIGCGSCFLIAFLIL 276
Cdd:cd17325  359 AAAALLLLAAVLFLLLR 375
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 137-292 1.28e-12

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 69.55  E-value: 1.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 137 MVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGisptiAISSGV--- 213
Cdd:cd17472   33 LIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG-----AISSVVmal 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 214 VGDFTLKHERG---TFVGATSGFVLLgqcFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLILPETKRTIAGNLSIK 290
Cdd:cd17472  108 LADLTREENRTkamALIGASIGIAFA---ISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEK 184


                 ..
gi 398365123 291 PK 292
Cdd:cd17472  185 KK 186
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 123-276 2.13e-12

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 68.83  E-value: 2.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 123 ALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIG 202
Cdd:cd17476   20 ILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLG 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365123 203 ISPTIAISSGVVGDFTLKHERGTFV----GATSGfvlLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLIL 276
Cdd:cd17476  100 PAFLLPNAMALLGRTYPPGPRKNIVfslfGATAP---LGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFWT 174
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 122-282 4.87e-12

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 67.66  E-value: 4.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 122 PALRQLEKQFNVDENMVNVTVVV----YLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRC 197
Cdd:cd17388   20 PVLPTLLREFVGDSADAATHYGVllalYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRI 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 198 IQSIgISPTIAISSGVVGDFTLKHERgtfvgaTSGFVLLGQCF------GSLIGAVLtARWDWRAIFWFLTIGCGSCFLI 271
Cdd:cd17388  100 IAGI-TGATGAVAAAYIADVTPPEQR------ARNFGLLGAAFglgfiaGPALGGLL-GEISPRAPFLVAAGLNGLNFLL 171

                        170
                 ....*....|.
gi 398365123 272 AFLILPETKRT 282
Cdd:cd17388  172 GLFVLPESLPP 182
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 142-289 2.40e-11

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 65.29  E-value: 2.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 142 VVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGiSPTIAISSGVVGDFTLKH 221
Cdd:cd17330   40 QSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLT-GGNVSVAQAYIADITDEE 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365123 222 ERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLILPETKRTIAGNLSI 289
Cdd:cd17330  119 ERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLRRLLLVYFLI 186
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 129-277 4.04e-11

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 64.87  E-value: 4.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 129 KQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIA 208
Cdd:cd17370  227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQES 306

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365123 209 ISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFltigCGSCFLIAFLILP 277
Cdd:cd17370  307 IERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF----SAVLALIALLLLL 371
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 141-274 1.39e-10

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 63.80  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 141 TVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLK 220
Cdd:cd06179   37 ISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNK 116

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 398365123 221 HeRGTFVGATSGFVLLGQCFGSLIGAVLTARWD--WRAIFWFLTIGCGSCFLIAFL 274
Cdd:cd06179  117 Y-RGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYINAIFNALALILLFF 171
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 155-278 1.75e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 63.14  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  155 VSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGA-TSGF 233
Cdd:TIGR00895  71 FFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLmFCGY 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 398365123  234 VlLGQCFGSLIGAVLTARWDWRAIFWFLTIgcGSCFLIAFLI--LPE 278
Cdd:TIGR00895 151 P-IGAAVGGFLAGWLIPVFGWRSLFYVGGI--APLLLLLLLMrfLPE 194
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
102-238 3.94e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 61.53  E-value: 3.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 102 MVAILTMCGFWSSLGSPIYYPALrqLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASI 181
Cdd:COG2814  211 LLLLLAFLLGFGFFALFTYLPLY--LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 398365123 182 GLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQ 238
Cdd:COG2814  289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 155-297 4.42e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 61.46  E-value: 4.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 155 VSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFV 234
Cdd:cd17489   50 FAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLAT 129

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398365123 235 LLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLIL--PETKRTIAGNLSIKPKRFINR 297
Cdd:cd17489  130 TLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKdpPPVAAEEAEAGTRAFRRLVEK 194
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 155-279 5.44e-10

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 61.06  E-value: 5.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 155 VSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFV 234
Cdd:cd17365   53 LAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGY 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 398365123 235 LLGQCFGSLIGAVLTARWDWRAIFWFltigCGSCFLIAFLILPET 279
Cdd:cd17365  133 PLGAALGGFLAAALIPAFGWRSVFLL----GGVPPLILLPLLRGT 173
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
122-291 6.78e-10

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 61.11  E-value: 6.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 122 PALRQLEKQFNVDENMVNVTVVVYLLfQGIS-PTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQS 200
Cdd:PRK15402  34 PGMLAVVEDFNAGAEWVPTSMTAYLA-GGMFlQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQG 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 201 IGISPTiaissGVVGDFTLKHergTFVGATS--------GFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIA 272
Cdd:PRK15402 113 IGLCFI-----GAVGYAAIQE---SFEEADAikitalmaNVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGL 184

                        170
                 ....*....|....*....
gi 398365123 273 FLILPETKRTIAGNLSIKP 291
Cdd:PRK15402 185 WRAMPETAGRVGEKLSLKE 203
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
104-302 6.82e-10

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 61.06  E-value: 6.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 104 AILTMCGFwssLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGL 183
Cdd:PRK11043  12 AGLSMLGF---LATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGM 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 184 ACAPSYGVIIFLRCIQSIGI-SPTIAISSGVVGDFTLKHERGTFvgAT-SGFVLLGQCFGSLIGAVLTARWDWRAIFWFL 261
Cdd:PRK11043  89 LWVESAAQLLVLRFVQAVGVcSAAVIWQALVIDRYPAQKANRVF--ATiMPLVALSPALAPLLGAWLLNHFGWQAIFATL 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 398365123 262 TiGCGSCFLIAFLILPETKRTIAGnlSIKPKRFIN--RAPIFL 302
Cdd:PRK11043 167 F-AITLLLILPTLRLKPSKKARKQ--SQDALTFKQllKSKTYL 206
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 124-286 1.62e-09

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 59.94  E-value: 1.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 124 LRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGI 203
Cdd:cd17328   22 LPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGE 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 204 SPTIAISSGVVGDFTLKHERGTFVG----ATSGFVLLGQCFGSLIGAvltARWDWRAIFWF---LTIGCGscfLIAFLIL 276
Cdd:cd17328  102 ASYSPIAPTIIADLFPKEKRTRALGvfyfAIPLGSGLGYVVGGLVAQ---ATGGWRWAFRVtgvLGVLLA---ILLLLFV 175

                        170
                 ....*....|
gi 398365123 277 PETKRTIAGN 286
Cdd:cd17328  176 REPPRGAAEG 185
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
115-304 1.92e-09

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 59.65  E-value: 1.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 115 LGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASigLACAPSYGVIIF 194
Cdd:PRK10473  17 AGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIAS--LLCSLAETSSLF 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 195 L--RCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIA 272
Cdd:PRK10473  95 LagRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLS 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 398365123 273 FLILPETKRTIAGNLSIKPK---------RFINRAPIFLLG 304
Cdd:PRK10473 175 LFILKETRPARAPAASSKPRensesllnrFFLSRLVITTLS 215
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 155-303 1.99e-09

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 59.55  E-value: 1.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 155 VSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTlKHERGTFVGATSGFV 234
Cdd:cd17329   54 IGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVT-TPENRTRAFSLLYWA 132

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365123 235 L-LGQCFGSLIGAVLtARWDWRAIFWFLTIGCGSCFLIAFLILPETKRTIAGN---LSIKPKRFINRAPIFLL 303
Cdd:cd17329  133 InLGVAIGPLLGGLL-LLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAektEILRGYKIVLRDRAFLL 204
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 155-270 3.04e-09

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 59.29  E-value: 3.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 155 VSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFV 234
Cdd:cd17362   58 VAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFI 137

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 398365123 235 LLGQCFGSLIG-AVLTARWDWRAIFWF-----LTIGCGSCFL 270
Cdd:cd17362  138 VLGILLGYVSGyAFADVVGGWRYMYGLaappaLLLGIGMWFL 179
Sugar_tr pfam00083
Sugar (and other) transporter;
140-281 3.05e-09

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 59.59  E-value: 3.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  140 VTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAP---SYGVIIFLRCIQSIGISPTIAISSGVVGD 216
Cdd:pfam00083  50 LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISE 129

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365123  217 FTLKHERGTFVGATSGFVLLGQCFGSLIGAVL---TARWDWRAIFWfLTIGCGSCFLIAFLILPETKR 281
Cdd:pfam00083 130 IAPKKLRGALGSLYQLAITFGILLAYIFGLGLnktSNSDGWRIPLG-LQLVPALLLIIGLLFLPESPR 196
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 124-281 4.81e-09

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 58.47  E-value: 4.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 124 LRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGI 203
Cdd:cd17371   22 LPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 204 SPTIAISSGVVGDFTLKHERGTFVGATSGF----VLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLiLPET 279
Cdd:cd17371  102 GGEWAAGAALMAEYVPARHRGKALGYVQSGwavgWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRF-VKEP 180


                 ..
gi 398365123 280 KR 281
Cdd:cd17371  181 PQ 182
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 122-285 5.51e-09

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 58.35  E-value: 5.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 122 PALRQLEKQFNVDENMVNVTVVVYLLFQG--ISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQ 199
Cdd:cd17315   18 GALLYIAKDLGFGLSTSLQGLVVSSLLLGaaIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 200 SIGISPTIAISSGVVGDFTLKHERGTFVG----ATSGFVLLGQCFGSLIGavLTARWDWRAIFWFLTIGCGsCFLIAFLI 275
Cdd:cd17315   98 GLGVGLASVLVPLYISEIAPAKIRGALGTlnqlMITFGILLAYLLGLALS--LSPPGWWRLMFALAAVPAL-LQLLLMFF 174

                        170
                 ....*....|
gi 398365123 276 LPETKRTIAG 285
Cdd:cd17315  175 LPESRALLVG 184
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 123-281 6.62e-09

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 57.96  E-value: 6.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 123 ALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIG 202
Cdd:cd17359   23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 203 ISPTIAISSGVVGDFTLKHERGTFVG----ATSGFVLLGQCFGSLIGAVLTARWD----WRAIFWFLTIGCgSCFLIAFL 274
Cdd:cd17359  103 VGGASALVPMYIAEVAPAEIRGRLVSlnqlMIVFGQLLAYIVNYLIANAGGADWLgaegWRWMLGLEAIPA-ILFLLGML 181


                 ....*..
gi 398365123 275 ILPETKR 281
Cdd:cd17359  182 FIPESPR 188
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 134-284 7.58e-09

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 57.59  E-value: 7.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 134 DENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGV 213
Cdd:cd17317   23 RDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVL 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398365123 214 VGDFTLKHERgTFVGatsgfvLLGQCFGSlIGAVLTARW-----DWRAIFWFLTIgcgSCFLIAFLILPETKRTIA 284
Cdd:cd17317  103 GMEIVGPKYR-SFVG------ILFGLFWA-LGYMLLALLaylirDWRWLQLAISL---PGLLFLLLLWWLPRRTII 167
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 151-281 1.34e-08

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 56.89  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 151 ISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGAT 230
Cdd:cd17360   50 VGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTIN 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 398365123 231 SGFVLLGQCFGSLIGAVLT-ARWDWRaifWFLTIGC--GSCFLIAFLILPETKR 281
Cdd:cd17360  130 VLFITGGQFVAYVINGAFSyLPGGWR---WMLGLAAvpAVLQFIGLLFLPESPR 180
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
94-290 3.55e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.06  E-value: 3.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  94 LSYGQKWGM-VAILTMCGFWSSLGS--PIYYPAlrqlekQFNVDENMVNVTVVVYLLFQGISPTVSGGLAD----CFGRR 166
Cdd:COG2211    7 LSLKEKLAYgLGDLGLNLAFGLLSAylLYFYTD------VLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 167 -PIILAGMLIYVIASIGLACAPS----------YGVIIFLRCIQSIGISPTIAISSGVVGDFtlkHERGTFVGATSGFVL 235
Cdd:COG2211   81 rPWILIGAIPLALSFVLLFTAPDlsptgkliyaLVTYLLLGLAYTLVNIPYSALGAELTPDY---EERTRLSSWRFAFAG 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398365123 236 LGQCFGSLIGAVLTARWD------WRAIFWFLTIGCGSCFLIAFLILPETKRTIAGNLSIK 290
Cdd:COG2211  158 LGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLK 218
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 93-273 3.90e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 55.51  E-value: 3.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  93 LLSYGQKWGMVAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLAD-CFGRRPIILA 171
Cdd:cd06174  196 LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLI 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 172 GMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTAR 251
Cdd:cd06174  276 GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355

                        170       180
                 ....*....|....*....|...
gi 398365123 252 -WDWRAIFWFLTIGCGSCFLIAF 273
Cdd:cd06174  356 tFGLTGAFLVLAVLLLLAAILLL 378
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 155-408 9.58e-08

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 54.58  E-value: 9.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 155 VSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGIS---PT-IAISSGVVGDftlkHERGTFVGAT 230
Cdd:PRK11551  69 LGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGgalPNlIALTSEAVGP----RLRGTAVSLM 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 231 SGFVLLGQCFGSLIGAVLTARWDWRAIFWflTIGCGSCFLIAFLI--LPETKRTIAGNLSIKPKRFINRApifLLGPVRR 308
Cdd:PRK11551 145 YCGVPFGGALASVIGVLAAGDAAWRHIFY--VGGVGPLLLVPLLMrwLPESRAFAQAAGAGKQRAPVLRA---LFGEGRA 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 309 RfkydnpdyETLdptipKLDLSSAGKILVLpEIILSLFPSgllfamwtLMlssISSGLSVAPYNYhlVIIGVcylpgGIG 388
Cdd:PRK11551 220 T--------ATL-----LLWISYFFTLIVL-YFLLNWLPS--------LL---VGQGLSRSQAGL--VQIAF-----NIG 267

                        250       260
                 ....*....|....*....|
gi 398365123 389 GLMGSFFTGRIIDMYFKRKI 408
Cdd:PRK11551 268 GALGSLLIGALMDRLRPRRV 287
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 155-281 1.34e-07

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 54.12  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 155 VSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGisptIAISSGVV----GDFTLKHERGTFvgat 230
Cdd:cd17358   60 LSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFG----GGAASVVVpvyiAEIAPKNVRGAL---- 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 398365123 231 SGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGsCFLIAFLILPETKR 281
Cdd:cd17358  132 GSLNQLLVNIGILLGYVLGSFLPWRTLALIGAIPPV-VFLILLFFIPESPR 181
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
100-303 1.46e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 53.72  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 100 WGMVAI-LTMCGFWSSLGspiyyPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVI 178
Cdd:COG2807   21 LAIVLVaLNLRPAITSVG-----PLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 179 ASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVG-DFtlKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAI 257
Cdd:COG2807   96 GLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKrWF--PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 398365123 258 FWFLTIGCGSCFLIAFLILPETKRTIAGNLSIKPKRFINRAPIFLL 303
Cdd:COG2807  174 LAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWL 219
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 155-282 1.87e-07

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 53.45  E-value: 1.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 155 VSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISpTIAISSGVVGDFTLKHERGTFVgatsgfV 234
Cdd:cd17374   54 IFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVS-GISINTLILGTEWTTPRHRALA------I 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 398365123 235 LLGQCFGSlIGAVLTA------RwDWRAIFWFLTIGCGSCFLIaFLILPetKRT 282
Cdd:cd17374  127 TLTSCFFS-IGQMLLAglayaiR-DWRLLQLVVSVPFFLFFLY-SWWLP--KRT 175
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
102-284 1.92e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 53.75  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 102 MVAILTMCGFWSSLGSPIYYpalrqLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASI 181
Cdd:COG2211  235 LAYLLFFLALALVAALLLYY-----FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 182 GLACAP--SYGVIIFLRCIQSIGISPTIAISSGVVGD-------FTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARW 252
Cdd:COG2211  310 LLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 398365123 253 DWRA-----------IFWFLTIGCGSCFLIAFLIL---PETKRTIA 284
Cdd:COG2211  390 GYVAgaaqspsaltgIRLLFFLLPAVLLLLAALLLlfyPLTRERHA 435
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 163-276 2.12e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 53.34  E-value: 2.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 163 FGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGS 242
Cdd:cd17474  262 FGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGP 341

                         90       100       110
                 ....*....|....*....|....*....|....
gi 398365123 243 LIGAVLTARWDWRAIFWFltigCGSCFLIAFLIL 276
Cdd:cd17474  342 LLFGLLLEIFGLSAPFLV----GAAIALAAAVLL 371
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 137-299 5.01e-07

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 52.27  E-value: 5.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 137 MVNVTVVVYLLFqgiSPtVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIgISPTIAISSGVVGD 216
Cdd:cd17391   41 AFSSTFLVSAIF---SP-IWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FSGYVPNATALIAS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 217 FTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLILPETKRTIAGNLSIKPKRFIN 296
Cdd:cd17391  116 QTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWN 195


                 ...
gi 398365123 297 RAP 299
Cdd:cd17391  196 SVP 198
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 157-250 8.04e-07

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 51.51  E-value: 8.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 157 GGLADCFGRRPIILAGMLIYVIASIGLACAPS------YGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGAT 230
Cdd:cd17364   60 GFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAV 139

                         90       100
                 ....*....|....*....|
gi 398365123 231 SGFVLLGQCFGSLIGAVLTA 250
Cdd:cd17364  140 FAMQGFGILAGAIVTLILSA 159
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 151-281 8.24e-07

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 51.94  E-value: 8.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  151 ISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISpTIAISSGVVG-DFTLKHERGTFVGA 229
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIG-GIWVQAVVLNtEFLPKKQRAIVGTL 220

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 398365123  230 TSGFVLLGQCFGSLIgAVLTArwDWRAIFWFLTIGCGsCFLIAFLILPETKR 281
Cdd:TIGR00898 221 IQVFFSLGLVLLPLV-AYFIP--DWRWLQLAVSLPTF-LFFLLSWFVPESPR 268
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 111-399 9.80e-07

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 51.02  E-value: 9.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 111 FWSSLGSPIYyPALRQlekQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYG 190
Cdd:cd17478   10 FYQGFLPALL-PLLIA---KLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 191 VIIFLRCIQSIGISPTIAISSGVVGDFTlKHERGTfvgATSGFVL---LGQCFGSLIGAVLTARWDWRAIFWFLTIGcgs 267
Cdd:cd17478   86 LLLLLVALAGIGSAAFHPEGARLASQAA-GGRRGL---AMSIFSVggnLGFALGPLIAAALVALFGGLGLLILLIIP--- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 268 cFLIAFLILPETKRTIAGNLSIKPKRFINRAPIfllgpvrrrfkydnpdyetldptipKLDLSSAGKILVLpeIIL-SLF 346
Cdd:cd17478  159 -GLAVALLLLRLRPLKKPEAKKAAAKSSARSTL-------------------------KGVWRALLLLLII--VFLrSWV 210

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 398365123 347 PSGLLFAMWTLMlssISSGLSVAPYNYHLVIIgvcYLPGGIGGLMGSFFTGRI 399
Cdd:cd17478  211 LSSLTTFLPFYL---VQRGYSLVFAGLLLSLF---LFAGAIGTLIGGPLSDRF 257
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
111-312 1.04e-06

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 51.37  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 111 FWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYG 190
Cdd:PRK15403  26 FAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMT 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 191 VIIFLRCIQSIGISptiAISSgvVGDFTLKHERGT-----FVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGC 265
Cdd:PRK15403 106 QFLIARFIQGTSIC---FIAT--VGYVTVQEAFGQtkgikLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMG 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 398365123 266 GSCFLIAFLILPETKRTIAGNLSIKP--KRFIN--RAPIFLLGPVRRRFKY 312
Cdd:PRK15403 181 LIAFVGLLLAMPETVKRGAVPFSAKSvlRDFRNvfRNRLFLTGAATLSLSY 231
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
122-304 1.23e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.01  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 122 PALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSI 201
Cdd:COG0738   29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 202 GISPTIAISSGVVGDFTlKHERGTFVGATSGFVLLGQCFGSLIGAVLTAR---WDWRAIFWFLTIGC-GSCFLIAFLILP 277
Cdd:COG0738  109 GLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLlLLALLFLRSKLP 187

                        170       180
                 ....*....|....*....|....*...
gi 398365123 278 ETKRTIAGNLSI-KPKRFINRAPIFLLG 304
Cdd:COG0738  188 EIEEEEEEAAGSaASLKSLLKNPRLLLG 215
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 145-279 1.75e-06

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 50.35  E-value: 1.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 145 YLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQsiGISP-TIAISSGVVGDFTLKHER 223
Cdd:cd17389   73 FSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVG--GISKgNVSLSTAIVADVTSPKKR 150

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398365123 224 GT---FVG-ATSgfvlLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFL------IAFLILPET 279
Cdd:cd17389  151 SKgmaLIGvAFS----LGFIIGPMIGAYFASFTRSLGEVFFSMPALFALVLaladllFIFFFLPET 212
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 140-279 4.87e-06

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 49.07  E-value: 4.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 140 VTVVVYLLFQG--ISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISpTIAISSGVVGDF 217
Cdd:cd17372   36 VALITSVVFAGmmIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLG-GGPQLASWYLEF 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398365123 218 TLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGcGSCFLIAFLILPET 279
Cdd:cd17372  115 LPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVP-SSLLLVFYRWTPKT 175
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 100-276 5.42e-06

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 49.16  E-value: 5.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 100 WGMVAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCfGRRPIILAGMLIYVIA 179
Cdd:cd17336    2 KVFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGR-GHRPRWIGIGSILMGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 180 SIGLACAPSYgvIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLT---------- 249
Cdd:cd17336   81 GCFLLALPHF--LFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLriyvdfsrvp 158

                        170       180       190
                 ....*....|....*....|....*....|....
gi 398365123 250 ---ARWDWRAI-FW---FLTIGCgSCFLIAFLIL 276
Cdd:cd17336  159 lgiTPDDPRWIgAWwlgFLILGI-LLLIVSIPLF 191
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 113-399 5.45e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.77  E-value: 5.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 113 SSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYG-- 190
Cdd:cd06173   11 SALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGsl 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 191 ---VIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFltigCGS 267
Cdd:cd06173   91 slwLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAI----NAL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 268 CFLIAFLILpetkrtiagnLSIKPKRFINRAPifllgpvrrrfkydnpdyetlDPTIPKLDLSSAGKILVLPEIILSLFP 347
Cdd:cd06173  167 SFLLSALLL----------LFIRRPPPAAPGE---------------------SSSLLLRDLREGLRYLRRSPLLRLLLL 215

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 398365123 348 SGLLFAMWTLMLSSISSGLSVAPYNYHLVIIGVCYLPGGIGGLMGSFFTGRI 399
Cdd:cd06173  216 ALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRL 267
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 102-273 6.20e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 48.75  E-value: 6.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 102 MVAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVtvVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASI 181
Cdd:cd17316  181 LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYL--LLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 182 GLACAPSYGV--IIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGF-VLLGQCFGSLIGAVLTARWDWRAIF 258
Cdd:cd17316  259 PLFYLLSGSPtlLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLgRLGGGGAPPLIALLLASTGGTGVPA 338

                        170
                 ....*....|....*
gi 398365123 259 WFLTIGCGSCFLIAF 273
Cdd:cd17316  339 LILALLAIVALIVAL 353
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
144-275 7.81e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 48.33  E-value: 7.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 144 VYLLFQGISPTVSGGLADCFG-RRPIILAGMLIYVIASIGLACAPSYGVIIFLrCIQSIGISPTIAISSGVVGDFTLKHE 222
Cdd:COG2807  258 LFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWA-VLLGLGQGGLFPLALTLIGLRARTPA 336

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 398365123 223 RgtfVGATSGFVL----LGQCFG-SLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLI 275
Cdd:COG2807  337 E---AAALSGMAQsvgyLLAALGpLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 126-277 9.69e-06

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 48.09  E-value: 9.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 126 QLEKQFNVdeNMVNVTVVVYLLFQG--ISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGI 203
Cdd:cd17333   21 SLEEAFNL--NVADVSVIFSSQNAGylIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398365123 204 SPTIAISSGVVGDFtLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWraIFWFLTIGCGSCFLIAFLILP 277
Cdd:cd17333   99 GILDTGANTFVGAL-FEESSATRLNVLHGFFGLGALIGPLIATSLLTSELS--WSWAYLIIGLIYLLLAILILL 169
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 144-278 1.49e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 47.22  E-value: 1.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 144 VYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIqsIGI-SPTIAISSGVVGDFTLKHE 222
Cdd:cd17390   39 VYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIP--LGIfKHTQSLCKAYLSDLVSEQE 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 223 RGTFVGATSGFVLLGQCFGSLIGAVLTArwdWRAIFWFLTIGCGSCFL----IAFLILPE 278
Cdd:cd17390  117 RSRVLGRFNAASSLGFILGPVVGGHLAE---TDGGFYYVALLCSAIFIlnagLVWFLLSK 173
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 137-276 1.51e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 47.61  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 137 MVNVTVVVylLFQGIsptVSGGLADcFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGD 216
Cdd:cd17329  243 ALNALLIV--LLQFP---VARLVER-FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAA 316

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 217 FTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWdwraIFWFLTIGCGSCFLIAFLIL 276
Cdd:cd17329  317 LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLL----GPGLPWLILAALGLIAAALL 372
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
74-285 1.80e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.18  E-value: 1.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  74 DDKVDPTQQITAETKAPYTLLSYGQKWGMvAILTMCGFWSSLGSPIYYPALrqLEKQFNVDENMVNVTVVVYLLFQGISP 153
Cdd:COG2223  182 DPPAGAAAAAKASLRDQLEALRDPRFWLL-SLLYFGTFGSFIGFSSWLPPY--LVDQFGLSAATAGLLAALFALLGALGR 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 154 TVSGGLADCFGRRPIILAGMLIYVIASIGLAcAPSYGVIIFLRCIQSIGIspTIAISSGVVGDFTLKHERGTFVGATSGF 233
Cdd:COG2223  259 PLGGWLSDRIGGRRVLLIVFALMALGLLLLA-LALGSLWLFLVLFLLLGL--ALGGGNGAVFALVPDIFPTKNAGAVYGL 335

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 398365123 234 VLLGQCFGS-----LIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLILPETKRTIAG 285
Cdd:COG2223  336 VGAAGGLGGflgplLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 143-276 1.84e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 47.19  E-value: 1.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 143 VVYLLFQGIsptVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHE 222
Cdd:cd17330  221 IAGILAQLL---LIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKE 297

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 398365123 223 RGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIgcgsCFLIAFLIL 276
Cdd:cd17330  298 QGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAG----LLLIALFLL 347
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 156-281 3.31e-05

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 46.47  E-value: 3.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 156 SGGLADCFGRRPIILAGMLIYVI-ASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFV 234
Cdd:cd17356   65 SSFLSDRIGRKKSIQIGCVIYIIgAIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAI 144

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 398365123 235 llgqCFGSLIGAVL---TARWD----WRaIFWFLTIGCGSCFLIAFLILPETKR 281
Cdd:cd17356  145 ----TIGILVAYCInygTHKLDgsaqWR-IPLGLQIVWGLLLLIGMFFLPESPR 193
2A0112 TIGR00891
putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic ...
 157-280 3.39e-05

putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273324 [Multi-domain]  Cd Length: 405  Bit Score: 46.42  E-value: 3.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  157 GGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFvgatSGFVLL 236
Cdd:TIGR00891  68 GLWGDRYGRRLPMVTSIVLFSAGTLACGFAPGYITMFIARLVIGIGMGGEYGSSAAYVIESWPKHLRNKA----SGLLIS 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 398365123  237 GQCFGSLIGAVLTAR----WD--WRAIFWFltigcgSCFLIAFLI-----LPETK 280
Cdd:TIGR00891 144 GYAVGAVVAAQVYSLvvpvWGdgWRALFFI------SILPIIFALwlrknIPEAE 192
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 155-275 3.49e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 46.45  E-value: 3.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 155 VSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFV 234
Cdd:cd06173  263 LLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALN 342

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 398365123 235 LLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLI 275
Cdd:cd06173  343 SGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 143-261 4.26e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 46.02  E-value: 4.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 143 VVYLLFQgispTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHE 222
Cdd:cd17319   49 LGYALFQ----VPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARE 124

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 398365123 223 RGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFL 261
Cdd:cd17319  125 RGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIE 163
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 140-281 6.30e-05

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 45.57  E-value: 6.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 140 VTVVVYLLFQgISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISpTIAISSGVVGDFTL 219
Cdd:cd17441   39 LTSVVFIGMM-LSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIG-GVPQSVTLYAEFLP 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398365123 220 KHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGsCFLIAFLILPETKR 281
Cdd:cd17441  117 MKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLL-IFAVLCFWLPESAR 177
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 103-251 6.74e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 45.24  E-value: 6.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 103 VAILTMCGFWSSLGSPIYYpalrqLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIG 182
Cdd:cd17321  176 AAFLLGAALGGLLFLLPLY-----LQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLL 250

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365123 183 LACAP---SYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFG-SLIGAVLTAR 251
Cdd:cd17321  251 LALLGadsSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGvALLGALLTAG 323
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 157-258 1.15e-04

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 45.07  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 157 GGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTfvgaTSGFVLL 236
Cdd:PRK03893  76 GAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNK----ASGFLIS 151

                         90       100
                 ....*....|....*....|....*.
gi 398365123 237 GQCFGSLIGA----VLTARWDWRAIF 258
Cdd:PRK03893 152 GFSIGAVVAAqvysLVVPVWGWRALF 177
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 140-279 1.27e-04

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 44.41  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 140 VTVVVYLLFQGISpTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTiaiSSGVV--GDF 217
Cdd:cd17442   41 VTTMVFFGYMVFS-ILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGCGVSGH---SQGLIikTEF 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398365123 218 TLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGcGSCFLIAFLILPET 279
Cdd:cd17442  117 LPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIP-GIILIVVFKFIPRT 177
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 155-202 1.59e-04

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 44.26  E-value: 1.59e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 398365123 155 VSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIG 202
Cdd:cd17379   52 VIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLF 99
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 100-274 1.98e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 44.10  E-value: 1.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 100 WGMVAILTMCGFWSSlgsPIYYPALrqLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIA 179
Cdd:cd17473  202 IYFLAFLAMLLFYVI---PIQLPFL--LQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 180 SIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLI-GAVLTARWDWRAIF 258
Cdd:cd17473  277 FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVlGPLVNLTGGLSGAF 356

                        170
                 ....*....|....*.
gi 398365123 259 WFLTIGCGSCFLIAFL 274
Cdd:cd17473  357 LILGVLALVLAIVLLL 372
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 157-249 1.98e-04

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 44.33  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  157 GGLADCFGRRPIILAGMLIYVIASIGLACAPSY------GVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGAt 230
Cdd:TIGR00887  77 GWLADKLGRKRVYGMELIIMIIATVASGLSPGSspksvmATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAA- 155

                          90
                  ....*....|....*....
gi 398365123  231 sgfVLLGQCFGSLIGAVLT 249
Cdd:TIGR00887 156 ---VFAMQGFGILAGAIVA 171
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 144-275 2.06e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 43.80  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 144 VYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCI----QSIGISPtiaiSSGVVGDFTL 219
Cdd:cd17312   46 AFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLnglfQSMGWPP----CVKLLGNWFS 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 398365123 220 KHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGC--GSCFLIAFLI 275
Cdd:cd17312  122 KKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGlvVAIILFFFLR 179
PRK14995 PRK14995
SmvA family efflux MFS transporter;
157-258 2.53e-04

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 43.95  E-value: 2.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 157 GGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTI-AISSGVVGDFTLKHERGTFVGATSGFVL 235
Cdd:PRK14995  62 GALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVpATLAGIRATFTEEKQRNMALGVWAAVGS 141

                         90       100
                 ....*....|....*....|...
gi 398365123 236 LGQCFGSLIGAVLTARWDWRAIF 258
Cdd:PRK14995 142 GGAAFGPLVGGILLEHFYWGSVF 164
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 137-278 2.95e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 43.38  E-value: 2.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 137 MVNVTVVVYLLFQGIsptvsggLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISP-TIAISSGVVG 215
Cdd:cd17475   39 ALNLGVAVSMLPAGW-------LLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSvQPGGGRAIMR 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365123 216 DFTlKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLILPE 278
Cdd:cd17475  112 WFP-PRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYRE 173
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 142-281 3.30e-04

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 43.25  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 142 VVVYLLFQGISPTVSGG-LADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLK 220
Cdd:cd17435   41 VVSSLLIGALLASLTGGvLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQ 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398365123 221 HERGTFVGATSGFVLLGQCFGSLIGAVLTARWD-WRAIFWfLTIGCGSCFLIAFLILPETKR 281
Cdd:cd17435  121 HRRGLLVSLNELMIVIGILLAYISNYAFANVSNgWKYMFG-LVIPLAALQAIAMYFLPPSPR 181
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 157-293 3.32e-04

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 43.44  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 157 GGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVI--------IFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVG 228
Cdd:cd17367   61 GRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIgiwapiilLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSS 140

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398365123 229 ATSGFVLLGQCFGSLIGAVLT--------ARWDWRAIFWFltigCGSCFLIAFLI---LPETKRTIAGNLSIKPKR 293
Cdd:cd17367  141 FQYVTLIGGQLLALGVLLVLQhtlgedqmAAWGWRIPFLL----GGVLAVVVLWLrrgLEETESFEAIAESNEASA 212
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 151-275 3.43e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.31  E-value: 3.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 151 ISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDfTLKHERGTFVGAT 230
Cdd:cd17324  249 VGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR-LAPEARGLASSLY 327

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 398365123 231 SGFVLLGQCFGSLIGAVLTARWDWRAIFWFltigCGSCFLIAFLI 275
Cdd:cd17324  328 LAAYNLGGALGAALGGLVLDHGGWAGVGWV----GAALLLLALLL 368
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 155-281 4.15e-04

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 43.13  E-value: 4.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 155 VSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVI--------IFLRCIQSIGISPTIAISSGVVGDFTLKHERGTF 226
Cdd:cd17368   59 VLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATIgiaapllvLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFY 138

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398365123 227 VGATSGFVLLGQCFGSLIGAVLT--------ARWDWRAIFWF-LTIGCGSCFLIAFLILPETKR 281
Cdd:cd17368  139 TSWQSASQQVAIVAGALVGYLLSltltaealAEWGWRIPFFIgLLIIPLGLWLRRSLEETEAFL 202
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 156-281 4.41e-04

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 42.77  E-value: 4.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 156 SGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVL 235
Cdd:cd17437   52 AGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFIN 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 398365123 236 LGQCFG---SLIGAVLTARWDWRAIfwfLTIGCGSCFLIAF--LILPETKR 281
Cdd:cd17437  132 IGILLGyvsNYAFSGLPLHVGWRLM---LGVGAVPSLFLAIgvLAMPESPR 179
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 81-273 5.61e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.54  E-value: 5.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  81 QQITAETKAPYTLLSYGQKWGMVAILTMCGF---WSSLGSPIYYPalrQLEKQFNVDENMVNVTVVVYLLFQGISPTVSG 157
Cdd:cd17478  175 PEAKKAAAKSSARSTLKGVWRALLLLLIIVFlrsWVLSSLTTFLP---FYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGG 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 158 GLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIqSIGISPTIAISSGVVGDftLKHERgtfVGATSGFVL-L 236
Cdd:cd17478  252 PLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLA-GFLLFASFPVTVVLAQE--LLPGN---VGLASGLMMgL 325

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 398365123 237 GQCFGSLIGAVLTARWDWRAI---FWFLTIGCGSCFLIAF 273
Cdd:cd17478  326 SFGLGGIGAPVLGALADAFGLesvLLILALLPLLGALLAF 365
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 134-254 6.77e-04

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 42.32  E-value: 6.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 134 DENMVNVTVVVYLLFQgISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGV 213
Cdd:cd17439   33 DSNKGMLGLIVYLGMM-VGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSY 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 398365123 214 VGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDW 254
Cdd:cd17439  112 FSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW 152
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 151-277 6.81e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 42.22  E-value: 6.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 151 ISPTVSGGLADCFGRRPIILAGMLIYVIAS--IGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVG 228
Cdd:cd17318   71 LTQIPGGYLAEKYGAKRVLGYSILITALLTllTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTS 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 398365123 229 atsgFVLLGQCFGSLI----GAVLTARWDWRAIFWFL-TIGCGSCFLIAFLILP 277
Cdd:cd17318  151 ----IAYSGSQFGTVIamplSGFLCESLGWPSIFYIFgGLGLLWCLLWFFLVLP 200
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 135-286 7.51e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 42.25  E-value: 7.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 135 ENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACA---PSYGVIIFLRCIQSIGISPTIAISS 211
Cdd:cd17357   48 DLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACGLSTGFVP 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 212 GVVGDFTLKHERGTFvgatSGFVLLGQCFGSLIGAVLTARW------DWRAIFwFLTIGCGSCFLIAFLILPETKRTIAG 285
Cdd:cd17357  128 MYLQEISPSELRGAL----GSLTQIGVTLGILLGQVFGLPSvlgtetLWPYLL-FFPGIPALLQLAALPFFPESPKFLLI 202


                 .
gi 398365123 286 N 286
Cdd:cd17357  203 S 203
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 156-276 8.17e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.15  E-value: 8.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 156 SGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFtLKHERGTfvgATSGF-- 233
Cdd:cd17471  255 AGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDL-MPGQPGL---ATTLYsn 330

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 398365123 234 -VLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCgscfLIAFLIL 276
Cdd:cd17471  331 aSRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLA----LLALVLL 370
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 157-273 8.43e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.78  E-value: 8.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 157 GGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTI-AISSGVVGDFTlkhERGTFVGATSGFVL 235
Cdd:cd17477  244 GWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLyTLALALAGDRL---PGDELVAANAALLL 320

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 398365123 236 ---LGQCFGSLIGAVLTARWDWRAIFWFLtIGCGSCFLIAF 273
Cdd:cd17477  321 lygLGSVIGPLLAGALMDAFGPHGLFLFL-AAVALLFLLFL 360
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 163-303 8.92e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 41.76  E-value: 8.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 163 FGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRC-IQSIGIS--PTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQC 239
Cdd:cd17471   60 GDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVvLLSLGAAafPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWV 139

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398365123 240 FGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLILPETKRTIAGNLSIKPKRFINRAPIFLL 303
Cdd:cd17471  140 IGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLL 203
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 150-283 1.06e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 41.59  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  150 GISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVga 229
Cdd:TIGR00881  44 GISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWV-- 121

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 398365123  230 tsGFVLLGQCFGSLIGAVLTA-----RWDWRAIFWFLTIGCGSCFLIAFLILPETKRTI 283
Cdd:TIGR00881 122 --SFWNCSHNVGGGLLPPLVLfgiaeLYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSC 178
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 144-276 1.41e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 41.10  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 144 VYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSG-VVGDFTLKHE 222
Cdd:cd17355   46 VGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFaTVAAWWFERR 125

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 398365123 223 RGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLIL 276
Cdd:cd17355  126 RGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLL 179
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 155-303 1.45e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.99  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 155 VSGGLADCFGRR-PIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIG----ISPTIAIssgvVGDFTLKHERGtfvga 229
Cdd:cd17370   53 FSGYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGkgirTPPRDAL----LADATPPSGRG----- 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 230 tSGFVL------LGQCFGSLIGAVLTARW--DWRAIFWFLTI--GCGSCFLIAFLILPETKR-TIAGNLSIKPKRFINRA 298
Cdd:cd17370  124 -KAFGLhraldtLGAVLGPLLAALLLYLLggNYRTIFLLAAIpaLLALLILLFVVKEYPRPPkLRKKSKKTSLKKLPKAF 202


                 ....*
gi 398365123 299 PIFLL 303
Cdd:cd17370  203 WLYLL 207
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 151-277 1.69e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 41.00  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 151 ISPTVSGGLADCFGRRPIILAGMLIYVIASI--GLACAPSYGVIIFLRCIQSIG---ISPTIA--ISSGVvgdftLKHER 223
Cdd:cd17380   49 LTQVLGGYLADRFGGKKVLLLAVALWSLATLltPLLAYSSLPLLILSRILLGLGegvHFPSMTslFSRWV-----PVSER 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 398365123 224 GTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIF-WFLTIGCGSCFLIAFLILP 277
Cdd:cd17380  124 SRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFyFFGLLGLLWALVWLIYLPP 178
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 157-297 1.73e-03

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 41.27  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  157 GGLADCFGRRPIILAGMLIYVIASIGLAcaPSYGV----IIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSG 232
Cdd:TIGR00894  97 GYLAGKYVFKWSIGIGMFLSSVISIVIP--WAAGGgialVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTS 174

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398365123  233 FVLLGQCFGSLIGAVLTARWD-WRAIFWFLTIgCGSCFLIAFLILPETKRTIAGNLSIKPKRFINR 297
Cdd:TIGR00894 175 GFQLGTFIFLPISGWLCESWGgWPMIFYVFGI-VGCAWSLLWFVFPADDPSIHPCISKFEKKYINS 239
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 155-304 2.08e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 40.75  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 155 VSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVgatsGFV 234
Cdd:cd06180   53 LASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLI----GLL 128

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398365123 235 LLGQCFGSLIGAVLTAR-----WDWRAIFWFLTIGCGSCFLIAFLILPETKRTIAGNLSIKPKRFINRaPIFLLG 304
Cdd:cd06180  129 FAGVGLGIALSGLLVPAglgggLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNR-PLWRLA 202
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 157-254 5.32e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 39.52  E-value: 5.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 157 GGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLL 236
Cdd:cd17438   55 GGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMI 134

                         90
                 ....*....|....*...
gi 398365123 237 GQCFGSLIGAVLTARWDW 254
Cdd:cd17438  135 GGLYASAMAWSIIPHYGW 152
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 127-274 5.34e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.43  E-value: 5.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 127 LEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASI----GLACAPSYGVIIFLRCIQSIG 202
Cdd:cd17369  255 ATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFpffwLLDTGSTWLIVLAAVVVLGVL 334

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398365123 203 ISPTIAISSGVVGDFTLKHER--GTFVGATSGFVLLGQcFGSLIGAVLTARW-DWRAIFWFLTIGCGSCFLIAFL 274
Cdd:cd17369  335 HGMMYGPQAAFLAELFPTRVRytGASLGYQLGAILGGG-FAPLIATALVAATgSWWPVALYLAALAVISLVAALF 408
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 132-254 6.83e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 39.39  E-value: 6.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 132 NVDENMVNVTVVVYLLfqgISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISS 211
Cdd:cd17363   33 NSNKGMLGLIVYLGMM---VGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVF 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 398365123 212 GVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDW 254
Cdd:cd17363  110 SYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGW 152
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 157-295 7.08e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.13  E-value: 7.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 157 GGLADCFGRR-PIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTlKHERGTFVGATSGFVL 235
Cdd:cd17490   52 GILSDRIGKRkLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFP-PDEAAKAMGLINLVNN 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 236 LGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLIlpETKRTIAGNLSIKPKRFI 295
Cdd:cd17490  131 LGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFI--KEERREKKPVLTELKELL 188
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 127-250 7.38e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 39.13  E-value: 7.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 127 LEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSY-GVIIFLRCIQSIGISP 205
Cdd:cd17353   29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLpLLFLGYGVLGGIGAGI 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 398365123 206 TIAISSGVVgdftLKH--ERgtfVGATSGFVLLGQCFGSLIGAVLTA 250
Cdd:cd17353  109 GYITPVSTA----VKWfpDK---RGLATGIVIAGFGLGSLIFSPLIA 148
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 157-254 8.83e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 39.19  E-value: 8.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123  157 GGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLL 236
Cdd:TIGR01299 223 GGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMI 302

                          90
                  ....*....|....*...
gi 398365123  237 GQCFGSLIGAVLTARWDW 254
Cdd:TIGR01299 303 GGIYAAAMAWAIIPHYGW 320
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
144-284 9.67e-03

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 38.75  E-value: 9.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365123 144 VYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSI--GISPTiaiSSGVVGDFTLKH 221
Cdd:PRK09874  62 ITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLlgGFVPN---ANALIATQVPRN 138

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365123 222 ERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLILPETKRTIA 284
Cdd:PRK09874 139 KSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPVS 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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