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Conserved domains on  [gi|398364727|ref|NP_012907|]
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WD-repeat containing protein SWD2 [Saccharomyces cerevisiae S288C]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
28-322 1.23e-25

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 1.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727  28 GPVTSLNFDDNGQFLLTSSSNDTMQLYSATNCKFLDTIASKKYGCHSAIFtHAQNECIYSStmkNFD--IKYLNLETNQY 105
Cdd:COG2319  121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF-SPDGKLLASG---SDDgtVRLWDLATGKL 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 106 LRYFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWDLKISKPQVIIP--SLVPNCIAYDPSGLVFALGNPENfEIGLYNL 183
Cdd:COG2319  197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADG-TVRLWDL 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 184 KkiqegPFLIIKINDATFSQWNKLEFSNNGKYLLVGSSIGKHLIFDAFTGQQLFELIGTRAfpmreflDSGSACFTPDGE 263
Cdd:COG2319  276 A-----TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG-------AVRSVAFSPDGK 343

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398364727 264 FVLGTDYDGRIAIWNHSDSISNKVLRpqgfipcvSHETCPRSIAFNPKYSMFVTA--DETV 322
Cdd:COG2319  344 TLASGSDDGTVRLWDLATGELLRTLT--------GHTGAVTSVAFSPDGRTLASGsaDGTV 396
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
28-322 1.23e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 1.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727  28 GPVTSLNFDDNGQFLLTSSSNDTMQLYSATNCKFLDTIASKKYGCHSAIFtHAQNECIYSStmkNFD--IKYLNLETNQY 105
Cdd:COG2319  121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF-SPDGKLLASG---SDDgtVRLWDLATGKL 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 106 LRYFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWDLKISKPQVIIP--SLVPNCIAYDPSGLVFALGNPENfEIGLYNL 183
Cdd:COG2319  197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADG-TVRLWDL 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 184 KkiqegPFLIIKINDATFSQWNKLEFSNNGKYLLVGSSIGKHLIFDAFTGQQLFELIGTRAfpmreflDSGSACFTPDGE 263
Cdd:COG2319  276 A-----TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG-------AVRSVAFSPDGK 343

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398364727 264 FVLGTDYDGRIAIWNHSDSISNKVLRpqgfipcvSHETCPRSIAFNPKYSMFVTA--DETV 322
Cdd:COG2319  344 TLASGSDDGTVRLWDLATGELLRTLT--------GHTGAVTSVAFSPDGRTLASGsaDGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-322 2.56e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 2.56e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727  28 GPVTSLNFDDNGQFLLTSSSNDTMQLYSATNCKFLDTIASKKyGCHSAIFTHAQNECIYSSTMkNFDIKYLNLETNQYLR 107
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT-GPVRDVAASADGTYLASGSS-DKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 108 YFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWDLKISKPQVIIP---SLVpNCIAYDPSGLvFALGNPENFEIGLYNLK 184
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtDWV-NSVAFSPDGT-FVASSSQDGTIKLWDLR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 185 KIQEGpfliikindATF----SQWNKLEFSNNGKYLLVGSSIGKHLIFDAFTGQQLFELIGTRAFPMrefldsgSACFTP 260
Cdd:cd00200  166 TGKCV---------ATLtghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN-------SVAFSP 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398364727 261 DGEFVLGTDYDGRIAIWNHSDSISNKVLRpqgfipcvSHETCPRSIAFNPKYSMFVTA--DETV 322
Cdd:cd00200  230 DGYLLASGSEDGTIRVWDLRTGECVQTLS--------GHTNSVTSLAWSPDGKRLASGsaDGTI 285
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-141 7.88e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 7.88e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 398364727   102 TNQYLRYFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWD 141
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
103-141 4.46e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 4.46e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 398364727  103 NQYLRYFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWD 141
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
28-322 1.23e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 1.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727  28 GPVTSLNFDDNGQFLLTSSSNDTMQLYSATNCKFLDTIASKKYGCHSAIFtHAQNECIYSStmkNFD--IKYLNLETNQY 105
Cdd:COG2319  121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF-SPDGKLLASG---SDDgtVRLWDLATGKL 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 106 LRYFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWDLKISKPQVIIP--SLVPNCIAYDPSGLVFALGNPENfEIGLYNL 183
Cdd:COG2319  197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADG-TVRLWDL 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 184 KkiqegPFLIIKINDATFSQWNKLEFSNNGKYLLVGSSIGKHLIFDAFTGQQLFELIGTRAfpmreflDSGSACFTPDGE 263
Cdd:COG2319  276 A-----TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG-------AVRSVAFSPDGK 343

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398364727 264 FVLGTDYDGRIAIWNHSDSISNKVLRpqgfipcvSHETCPRSIAFNPKYSMFVTA--DETV 322
Cdd:COG2319  344 TLASGSDDGTVRLWDLATGELLRTLT--------GHTGAVTSVAFSPDGRTLASGsaDGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-322 2.56e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 2.56e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727  28 GPVTSLNFDDNGQFLLTSSSNDTMQLYSATNCKFLDTIASKKyGCHSAIFTHAQNECIYSSTMkNFDIKYLNLETNQYLR 107
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT-GPVRDVAASADGTYLASGSS-DKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 108 YFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWDLKISKPQVIIP---SLVpNCIAYDPSGLvFALGNPENFEIGLYNLK 184
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtDWV-NSVAFSPDGT-FVASSSQDGTIKLWDLR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 185 KIQEGpfliikindATF----SQWNKLEFSNNGKYLLVGSSIGKHLIFDAFTGQQLFELIGTRAFPMrefldsgSACFTP 260
Cdd:cd00200  166 TGKCV---------ATLtghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN-------SVAFSP 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398364727 261 DGEFVLGTDYDGRIAIWNHSDSISNKVLRpqgfipcvSHETCPRSIAFNPKYSMFVTA--DETV 322
Cdd:cd00200  230 DGYLLASGSEDGTIRVWDLRTGECVQTLS--------GHTNSVTSLAWSPDGKRLASGsaDGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
28-278 3.99e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 3.99e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727  28 GPVTSLNFDDNGQFLLTSSSNDTMQLYSATNCKFLDTIASKKYGCHSAIFThAQNECIYSSTMKNfDIKYLNLETNQYLR 107
Cdd:COG2319  163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-PDGKLLASGSADG-TVRLWDLATGKLLR 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 108 YFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWDLKISKPQVIIPSLV--PNCIAYDPSGLVFALGNPENfEIGLYNLKK 185
Cdd:COG2319  241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSggVNSVAFSPDGKLLASGSDDG-TVRLWDLAT 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 186 IQEgpfliIKINDATFSQWNKLEFSNNGKYLLVGSSIGKHLIFDAFTGQQLFELIGTRAFPMrefldsgSACFTPDGEFV 265
Cdd:COG2319  320 GKL-----LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT-------SVAFSPDGRTL 387

                        250
                 ....*....|...
gi 398364727 266 LGTDYDGRIAIWN 278
Cdd:COG2319  388 ASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-278 6.03e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 6.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727  28 GPVTSLNFDDNGQFLLTSSSNDTMQLYSATNCKFLDTIASKKYGCHSAIFTHAQNecIYSSTMKNFDIKYLNLETNQYLR 107
Cdd:cd00200   52 GPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKVWDVETGKCLT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 108 YFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWDLKISKPQVIIPSLVP--NCIAYDPSGLVFALGNPENfEIGLYNLKK 185
Cdd:cd00200  130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGevNSVAFSPDGEKLLSSSSDG-TIKLWDLST 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 186 IQEGPFLIIKINDATFsqwnkLEFSNNGKYLLVGSSIGKHLIFDAFTGQQLFELIGTRAFpmrefldSGSACFTPDGEFV 265
Cdd:cd00200  209 GKCLGTLRGHENGVNS-----VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNS-------VTSLAWSPDGKRL 276

                        250
                 ....*....|...
gi 398364727 266 LGTDYDGRIAIWN 278
Cdd:cd00200  277 ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
95-322 1.91e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 1.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727  95 IKYLNLETNQYLRYFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWDLKISKPQVII--PSLVPNCIAYDPSGLVFALGN 172
Cdd:COG2319  102 VRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLtgHSGAVTSVAFSPDGKLLASGS 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 173 PENfEIGLYNLKKIQegpfLIIKINDATFSQWNkLEFSNNGKYLLVGSSIGKHLIFDAFTGQQLFELIGTRAFPMrefld 252
Cdd:COG2319  182 DDG-TVRLWDLATGK----LLRTLTGHTGAVRS-VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR----- 250

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398364727 253 sgSACFTPDGEFVLGTDYDGRIAIWnhsDSISNKVLRPQGfipcvSHETCPRSIAFNPKYSMFVTA--DETV 322
Cdd:COG2319  251 --SVAFSPDGRLLASGSADGTVRLW---DLATGELLRTLT-----GHSGGVNSVAFSPDGKLLASGsdDGTV 312
WD40 COG2319
WD40 repeat [General function prediction only];
98-322 1.01e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 1.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727  98 LNLETNQYLRYFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWDLKISKPQVII--PSLVPNCIAYDPSGLVFALGNpEN 175
Cdd:COG2319   63 LDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLtgHTGAVRSVAFSPDGKTLASGS-AD 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 176 FEIGLYNLKKIQegpfLIIKINDATFSQWNkLEFSNNGKYLLVGSSIGKHLIFDAFTGQQLFELIGTRAFPMrefldsgS 255
Cdd:COG2319  142 GTVRLWDLATGK----LLRTLTGHSGAVTS-VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR-------S 209

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398364727 256 ACFTPDGEFVLGTDYDGRIAIWNHSdsiSNKVLRPQGfipcvSHETCPRSIAFNPKYSMFVTA--DETV 322
Cdd:COG2319  210 VAFSPDGKLLASGSADGTVRLWDLA---TGKLLRTLT-----GHSGSVRSVAFSPDGRLLASGsaDGTV 270
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-318 2.74e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 2.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 106 LRYFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWDLKISKPQ--VIIPSLVPNCIAYDPSGLVFALGNPENFeIGLYNL 183
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLrtLKGHTGPVRDVAASADGTYLASGSSDKT-IRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 184 KKIQegpfLIIKINDATfSQWNKLEFSNNGKYLLVGSSIGKHLIFDAFTGQQLFELIGTRAFPMrefldsgSACFTPDGE 263
Cdd:cd00200   81 ETGE----CVRTLTGHT-SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVN-------SVAFSPDGT 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 398364727 264 FVLGTDYDGRIAIWNHSDSISNKVLRpqgfipcvSHETCPRSIAFNPKYSMFVTA 318
Cdd:cd00200  149 FVASSSQDGTIKLWDLRTGKCVATLT--------GHTGEVNSVAFSPDGEKLLSS 195
WD40 COG2319
WD40 repeat [General function prediction only];
28-143 5.82e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 5.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727  28 GPVTSLNFDDNGQFLLTSSSNDTMQLYSATNCKFLDTIASKKYGCHSAIFtHAQNECIYSSTMKNfDIKYLNLETNQYLR 107
Cdd:COG2319  289 GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF-SPDGKTLASGSDDG-TVRLWDLATGELLR 366

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 398364727 108 YFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWDLK 143
Cdd:COG2319  367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-141 7.88e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 7.88e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 398364727   102 TNQYLRYFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWD 141
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
103-141 4.46e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 4.46e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 398364727  103 NQYLRYFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWD 141
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
120-329 4.90e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 38.35  E-value: 4.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 120 KMNPVNDTFLSSSY----DESVRLWDL-----KISKPQVIIPSLVPNCIAYDPSG-LVFALGNPENFEIGLYNlkkiqeg 189
Cdd:COG2706    2 KRLLLSTFVYVGTYtsgeSEGIYVFRLdtatgELTLLGLVAALGNPSFLALSPDGrFLYAVNEVDDGGVSAFR------- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 190 pfliIKINDATFSQWNK----------LEFSNNGKYLLV----GSSIGKHLIfdAFTGQ-----QLFELIGTRAFPMREf 250
Cdd:COG2706   75 ----IDPADGTLTLLNTvssggaspchLSVDPDGRFLFVanygGGSVSVFPI--DADGSlgepvQVIQHEGSGPNPERQ- 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364727 251 ldSGSAC----FTPDGEFV----LGTDydgRIAIWNHSDsiSNKVLRPQGFIPcVSHETCPRSIAFNPKYSMFVTADE-- 320
Cdd:COG2706  148 --EGPHAhsvvFDPDGRFLyvpdLGTD---RIYVYRLDP--ATGKLPEPPEVS-LPPGSGPRHLAFHPNGRFAYVINEld 219

                        250
                 ....*....|
gi 398364727 321 -TVDFYVYDE 329
Cdd:COG2706  220 sTVSVYAYDA 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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