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Concise Results
Standard Results
Full Results
putative E3 ubiquitin-protein ligase HUL4 [Saccharomyces cerevisiae S288C]
Protein Classification
HECT-type E3 ubiquitin transferase ( domain architecture ID 11472073 )
HECT-type E3 ubiquitin transferase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates
List of domain hits
Name
Accession
Description
Interval
E-value
HUL4
COG5021 Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
1-892
0e+00
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain]
Cd Length: 872
Bit Score: 834.80
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 1 MVSLFDK L NAKKDG R DG S VSKELL S HSV A HTKNRLPK SG R R T S ERSL AA SV K DG S C S NS K SNK R N S S A SVS G EEDKS CL I 80
Cdd:COG5021 1 DLRVGGL L LEDLSC R LF S ELFRSN S SVR A EFDLSKDE SG V R N S LDYG AA GN K NM S L S DE K GLV R S S I A ALD G LQNRD CL R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 81 SL NC L CCGVPLRFPA S I T K FR C SA CQVT V IVKEP E INSN L E SS TH I SCTL E GL Q M V VRRCHDD L QR L KKTGI L DK E RKGL 160
Cdd:COG5021 81 SL DP L SVLSVDGLQT S E T S FR S SA LNPY V NEFLC E NDVR L S SS IT I QVSD E SK Q N V IEDVFSG L EN L GSVDV L ST E ATKG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 161 I FQPV I TYLL D RFHDVSI LN RS FL VHDG G KNI K MLNYE V LQRFY S ILS N LPTRK PY Y S M L CCCNDL LK RI T I N KGENL Q I 240
Cdd:COG5021 161 I DFLE I LITR D FLFSSCS LN SD FL KIIS G SSV K SRKLA V SNVEK S EPD N VLFGL PY R S A L TMRTNF LK LD T G N LSGEV Q A 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 241 L QY R WLL I I L N I P ti RTC L IRDRKSKNVFE T QQ IR AVSYE L AK R CIGY LS NL S TKT S QQLIQ SL RR T PT D N F SYQVEILN 320
Cdd:COG5021 241 L LA R YIS I K L V I K -- KLY L GPGPDASSRIS T LI IR LSNTN L NR R LSYI LS HS S FED S LLRLN SL FS T RA D S F GRTYYLDH 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 321 LY I NF Q F SR L L SN E LSNRTAKNN V KPE D - EMRSRLRR H HTTGHE FL STR P ISAQSNDK Q GS G F T HPVN NK MKFKFFQY E E 399
Cdd:COG5021 319 DR I LT Q Y SR P L LE E TLGESTSFL V VNN D d SSSIKDLP H QVGSNP FL EAH P EFSELLKN Q SR G T T RDFR NK PTGWSSSI E D 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 400 DWHIHSAAK LT FIYYVANT RR NGR G AL S IQ SFY NITLDFIDYK q DFDHWRGVAQ KT KM N Q L IEEWGNSTT KK CFSFCKYP 479
Cdd:COG5021 399 LGQFLFSDF LT SSSTYEDL RR EQL G RE S DE SFY VASNVQQQRA - SREGPLLSGW KT RL N N L YRFYFVEHR KK TLTKNDSR 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 480 fils LG IK IS IMEYE IRRI M E HEAEQA F LISLD K G K SV D V Y FK IKVRRD VISH DS L R C I KEHQ GD L LK S - L R IEFV N E P G 558
Cdd:COG5021 478 ---- LG SF IS LNKLD IRRI K E DKRRKL F YSLKQ K A K IF D P Y LH IKVRRD RVFE DS Y R E I MDES GD D LK K t L E IEFV G E E G 553
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 559 IDAGGL RK EW F FLL T K SL FNP MN GLF I YI K E SSRSWFAIDPPN fdksk GKNSQ L ELYYLF G V V M G L AI FN S T ILD L QF P K 638
Cdd:COG5021 554 IDAGGL TR EW L FLL S K EM FNP DY GLF E YI T E DLYTLPINPLSS ----- INPEH L SYFKFL G R V I G K AI YD S R ILD V QF S K 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 639 A L YKKL CSE P L S FE D YSE L F PE TS R N L IKM LN YTE D NF edvfsl TFET T YRNNNWILND S ksskey V TVEL CE NGRN VPI 718
Cdd:COG5021 629 A F YKKL LGK P V S LV D LES L D PE LY R S L VWL LN NDI D ET ------ ILDL T FTVEDDSFGE S ------ R TVEL IP NGRN ISV 696
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 719 T QS NK H E F V M K W V EFY L E K SI E P Q YNK F V SGF KRVFAEC n SIKL F NSE ELE R L VC G DE E Q tk F D FKSLR S V T K Y V g G FSD 798
Cdd:COG5021 697 T NE NK K E Y V K K V V DYK L N K RV E K Q FSA F K SGF SEIIPPD - LLQI F DES ELE L L IG G IP E D -- I D IDDWK S N T A Y H - G YTE 772
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 799 DS RAVC WFWEII ESW D YPLQK KLLQFVT ASD RIP AT G ISTIPFK ------ ISLL G SH D S D D LP L AHTCFN EIC L WN YSSK 872
Cdd:COG5021 773 DS PIIV WFWEII SEF D FEERA KLLQFVT GTS RIP IN G FKDLQGS dgvrkf TIEK G GT D D D R LP S AHTCFN RLK L PE YSSK 852
890 900
....*....|....*....|
gi 398364915 873 K KL EL KLL W AINE SE G Y G FR 892
Cdd:COG5021 853 E KL RS KLL T AINE GA G F G LL 872
Name
Accession
Description
Interval
E-value
HUL4
COG5021 Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
1-892
0e+00
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain]
Cd Length: 872
Bit Score: 834.80
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 1 MVSLFDK L NAKKDG R DG S VSKELL S HSV A HTKNRLPK SG R R T S ERSL AA SV K DG S C S NS K SNK R N S S A SVS G EEDKS CL I 80
Cdd:COG5021 1 DLRVGGL L LEDLSC R LF S ELFRSN S SVR A EFDLSKDE SG V R N S LDYG AA GN K NM S L S DE K GLV R S S I A ALD G LQNRD CL R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 81 SL NC L CCGVPLRFPA S I T K FR C SA CQVT V IVKEP E INSN L E SS TH I SCTL E GL Q M V VRRCHDD L QR L KKTGI L DK E RKGL 160
Cdd:COG5021 81 SL DP L SVLSVDGLQT S E T S FR S SA LNPY V NEFLC E NDVR L S SS IT I QVSD E SK Q N V IEDVFSG L EN L GSVDV L ST E ATKG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 161 I FQPV I TYLL D RFHDVSI LN RS FL VHDG G KNI K MLNYE V LQRFY S ILS N LPTRK PY Y S M L CCCNDL LK RI T I N KGENL Q I 240
Cdd:COG5021 161 I DFLE I LITR D FLFSSCS LN SD FL KIIS G SSV K SRKLA V SNVEK S EPD N VLFGL PY R S A L TMRTNF LK LD T G N LSGEV Q A 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 241 L QY R WLL I I L N I P ti RTC L IRDRKSKNVFE T QQ IR AVSYE L AK R CIGY LS NL S TKT S QQLIQ SL RR T PT D N F SYQVEILN 320
Cdd:COG5021 241 L LA R YIS I K L V I K -- KLY L GPGPDASSRIS T LI IR LSNTN L NR R LSYI LS HS S FED S LLRLN SL FS T RA D S F GRTYYLDH 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 321 LY I NF Q F SR L L SN E LSNRTAKNN V KPE D - EMRSRLRR H HTTGHE FL STR P ISAQSNDK Q GS G F T HPVN NK MKFKFFQY E E 399
Cdd:COG5021 319 DR I LT Q Y SR P L LE E TLGESTSFL V VNN D d SSSIKDLP H QVGSNP FL EAH P EFSELLKN Q SR G T T RDFR NK PTGWSSSI E D 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 400 DWHIHSAAK LT FIYYVANT RR NGR G AL S IQ SFY NITLDFIDYK q DFDHWRGVAQ KT KM N Q L IEEWGNSTT KK CFSFCKYP 479
Cdd:COG5021 399 LGQFLFSDF LT SSSTYEDL RR EQL G RE S DE SFY VASNVQQQRA - SREGPLLSGW KT RL N N L YRFYFVEHR KK TLTKNDSR 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 480 fils LG IK IS IMEYE IRRI M E HEAEQA F LISLD K G K SV D V Y FK IKVRRD VISH DS L R C I KEHQ GD L LK S - L R IEFV N E P G 558
Cdd:COG5021 478 ---- LG SF IS LNKLD IRRI K E DKRRKL F YSLKQ K A K IF D P Y LH IKVRRD RVFE DS Y R E I MDES GD D LK K t L E IEFV G E E G 553
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 559 IDAGGL RK EW F FLL T K SL FNP MN GLF I YI K E SSRSWFAIDPPN fdksk GKNSQ L ELYYLF G V V M G L AI FN S T ILD L QF P K 638
Cdd:COG5021 554 IDAGGL TR EW L FLL S K EM FNP DY GLF E YI T E DLYTLPINPLSS ----- INPEH L SYFKFL G R V I G K AI YD S R ILD V QF S K 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 639 A L YKKL CSE P L S FE D YSE L F PE TS R N L IKM LN YTE D NF edvfsl TFET T YRNNNWILND S ksskey V TVEL CE NGRN VPI 718
Cdd:COG5021 629 A F YKKL LGK P V S LV D LES L D PE LY R S L VWL LN NDI D ET ------ ILDL T FTVEDDSFGE S ------ R TVEL IP NGRN ISV 696
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 719 T QS NK H E F V M K W V EFY L E K SI E P Q YNK F V SGF KRVFAEC n SIKL F NSE ELE R L VC G DE E Q tk F D FKSLR S V T K Y V g G FSD 798
Cdd:COG5021 697 T NE NK K E Y V K K V V DYK L N K RV E K Q FSA F K SGF SEIIPPD - LLQI F DES ELE L L IG G IP E D -- I D IDDWK S N T A Y H - G YTE 772
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 799 DS RAVC WFWEII ESW D YPLQK KLLQFVT ASD RIP AT G ISTIPFK ------ ISLL G SH D S D D LP L AHTCFN EIC L WN YSSK 872
Cdd:COG5021 773 DS PIIV WFWEII SEF D FEERA KLLQFVT GTS RIP IN G FKDLQGS dgvrkf TIEK G GT D D D R LP S AHTCFN RLK L PE YSSK 852
890 900
....*....|....*....|
gi 398364915 873 K KL EL KLL W AINE SE G Y G FR 892
Cdd:COG5021 853 E KL RS KLL T AINE GA G F G LL 872
HECTc
cd00078 HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
521-890
1.38e-131
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
Pssm-ID: 238033 [Multi-domain]
Cd Length: 352
Bit Score: 398.09
E-value: 1.38e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 521 F KI K VRRD V I SH D S LR CIKEH - QG DL L K S L RI EFV N E P GIDAGG LRK E W F F L LT K S LFNP MN GLF I Y I k ESSRSWFAID P 599
Cdd:cd00078 1 L KI T VRRD R I LE D A LR QLSKV s SS DL K K V L EV EFV G E E GIDAGG VTR E F F T L VS K E LFNP SY GLF R Y T - PDDSGLLYPN P 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 600 PN F DKSK gkns Q L E L YYLF G VVM G L A IFNSTI LDL Q F PK A L YKKL CSE PLS F ED YS EL F PE TSRN L IKM L NYTE D nf ED V 679
Cdd:cd00078 80 SS F ADED ---- H L K L FRFL G RLL G K A LYEGRL LDL P F SR A F YKKL LGK PLS L ED LE EL D PE LYKS L KEL L DNDG D -- ED D 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 680 FS LTF ETTY rnnnwilnd SK S SKEY VTVEL CEN GR NV P I T QS NK H E F V MKW V EFY L E K S IE P Q YNK F VS GF KR V FA E c NS 759
Cdd:cd00078 154 LE LTF TIEL --------- DS S FGGA VTVEL KPG GR DI P V T NE NK E E Y V DLY V DYR L N K G IE E Q VEA F RD GF SE V IP E - EL 223
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 760 IK LF NS EELE R L V CG D E E qtk F D FKS L RSV T K Y V GG F S D DS RAVC WFWE II ES WDYPLQ KK L LQFVT A S D R I P AT G ISTI 839
Cdd:cd00078 224 LS LF TP EELE L L I CG S E D --- I D LED L KKN T E Y K GG Y S S DS PTIQ WFWE VL ES FTNEER KK F LQFVT G S S R L P VG G FADL 300
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 398364915 840 PF K ISLLGSHDS DD - LP L AHTCFN EIC L WN YSSK KK L EL KLL W AINE SE G Y G 890
Cdd:cd00078 301 NP K FTIRRVGSP DD r LP T AHTCFN LLK L PP YSSK EI L RE KLL Y AINE GA G F G 352
HECTc
smart00119 Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
544-889
1.17e-126
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
Pssm-ID: 214523
Cd Length: 328
Bit Score: 384.66
E-value: 1.17e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 544 DL L K S - L R IEF VN E P G I D A GG LRK E W FFLL T K S LFNP MN GLF I Y IKESS rs WFAID P PNFDKSKGKN S Q lel YYLF G V V M 622
Cdd:smart00119 1 DL K K R v L E IEF EG E E G L D G GG VTR E F FFLL S K E LFNP DY GLF R Y SPNDY -- LLYPN P RSGFANEEHL S Y --- FRFI G R V L 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 623 G L A IFNSTI LDL Q F PKAL YKKL CSE P LSFE D YSE L F PE TSRN L IKM L nytednfedvfs L TFE T TYRNNNWI - LNDSKSS 701
Cdd:smart00119 76 G K A LYDNRL LDL F F ARPF YKKL LGK P VTLH D LES L D PE LYKS L KWL L ------------ L NND T SEELDLTF s IVLTSEF 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 702 KEYVT VEL CEN G R N V P I T QS NK H E F V MKWV E FY L E K S IE P Q YNK F VS GF KR V FA E c N SI KLF NS EELE R L V CG DE E QTKF 781
Cdd:smart00119 144 GQVKV VEL KPG G S N I P V T EE NK K E Y V HLVI E YR L N K G IE K Q LEA F RE GF SE V IP E - N LL KLF DP EELE L L I CG SP E IDVD 222
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 782 D fks L R S V T K Y V GG F S DD S RAVC WFWE II ES WDYPLQK KLLQFVT A S D R I P AT G ISTIPF K ISLLGSH - D SDD LP L AHTC 860
Cdd:smart00119 223 D --- L K S N T E Y K GG Y S AN S QTIK WFWE VV ES FTNEERR KLLQFVT G S S R L P VG G FAALSP K FTIRKAG s D DER LP T AHTC 299
330 340
....*....|....*....|....*....
gi 398364915 861 FN EIC L WN YSSK KK L EL KLL W AINE SE G Y 889
Cdd:smart00119 300 FN RLK L PP YSSK EI L RE KLL L AINE GK G F 328
HECT
pfam00632 HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
570-892
1.37e-92
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.
Pssm-ID: 459880
Cd Length: 304
Bit Score: 294.52
E-value: 1.37e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 570 F LL T K S LF N P MN GLF I Y IK E SS R S wfa IDPPNFDKSKGKNSQ L ELYYLF G VVM G L AI F N STI LDL Q FP KAL YKKL CS EPL 649
Cdd:pfam00632 1 T LL S K E LF D P NY GLF E Y ET E DD R T --- YWFNPSSSESPDLEL L DYFKFL G KLL G K AI Y N GIL LDL P FP PFF YKKL LG EPL 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 650 SF ED YSELF PE TSRN L IKM LN YTE D NF ED v FS LTF ETTY rnnnwilndsks SK E YV T V EL CE NGRN V P I T QS NK H E FVMK 729
Cdd:pfam00632 78 TL ED LESID PE LYKS L KSL LN MDN D DD ED - LG LTF TIPV ------------ FG E SK T I EL IP NGRN I P V T NE NK E E YIRL 144
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 730 W V EFY L E KSIEPQ YNK F VS GF KR V FAE c NSIK LF NS EELE R L V CG DE E qtk F D FKS L RSV T K Y V GG FSDD S RAVC WFWEI 809
Cdd:pfam00632 145 Y V DYR L N KSIEPQ LEA F RK GF YS V IPK - EALS LF TP EELE L L I CG SP E --- I D VED L KKN T E Y D GG YTKN S PTIQ WFWEI 220
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 810 I E SWDYPLQKKL L Q FVT A S D R I P AT G ISTI P - F K I SLL G SH D S D D LP L AHTCFN EIC L WN YSSK KK L EL KLL W AI N E S EG 888
Cdd:pfam00632 221 L E EFSPEQRRLF L K FVT G S S R L P VG G FKSL P k F T I VRK G GD D D D R LP T AHTCFN RLK L PD YSSK EI L KE KLL I AI E E G EG 300
....
gi 398364915 889 Y G FR 892
Cdd:pfam00632 301 F G LS 304
Name
Accession
Description
Interval
E-value
HUL4
COG5021 Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
1-892
0e+00
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain]
Cd Length: 872
Bit Score: 834.80
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 1 MVSLFDK L NAKKDG R DG S VSKELL S HSV A HTKNRLPK SG R R T S ERSL AA SV K DG S C S NS K SNK R N S S A SVS G EEDKS CL I 80
Cdd:COG5021 1 DLRVGGL L LEDLSC R LF S ELFRSN S SVR A EFDLSKDE SG V R N S LDYG AA GN K NM S L S DE K GLV R S S I A ALD G LQNRD CL R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 81 SL NC L CCGVPLRFPA S I T K FR C SA CQVT V IVKEP E INSN L E SS TH I SCTL E GL Q M V VRRCHDD L QR L KKTGI L DK E RKGL 160
Cdd:COG5021 81 SL DP L SVLSVDGLQT S E T S FR S SA LNPY V NEFLC E NDVR L S SS IT I QVSD E SK Q N V IEDVFSG L EN L GSVDV L ST E ATKG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 161 I FQPV I TYLL D RFHDVSI LN RS FL VHDG G KNI K MLNYE V LQRFY S ILS N LPTRK PY Y S M L CCCNDL LK RI T I N KGENL Q I 240
Cdd:COG5021 161 I DFLE I LITR D FLFSSCS LN SD FL KIIS G SSV K SRKLA V SNVEK S EPD N VLFGL PY R S A L TMRTNF LK LD T G N LSGEV Q A 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 241 L QY R WLL I I L N I P ti RTC L IRDRKSKNVFE T QQ IR AVSYE L AK R CIGY LS NL S TKT S QQLIQ SL RR T PT D N F SYQVEILN 320
Cdd:COG5021 241 L LA R YIS I K L V I K -- KLY L GPGPDASSRIS T LI IR LSNTN L NR R LSYI LS HS S FED S LLRLN SL FS T RA D S F GRTYYLDH 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 321 LY I NF Q F SR L L SN E LSNRTAKNN V KPE D - EMRSRLRR H HTTGHE FL STR P ISAQSNDK Q GS G F T HPVN NK MKFKFFQY E E 399
Cdd:COG5021 319 DR I LT Q Y SR P L LE E TLGESTSFL V VNN D d SSSIKDLP H QVGSNP FL EAH P EFSELLKN Q SR G T T RDFR NK PTGWSSSI E D 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 400 DWHIHSAAK LT FIYYVANT RR NGR G AL S IQ SFY NITLDFIDYK q DFDHWRGVAQ KT KM N Q L IEEWGNSTT KK CFSFCKYP 479
Cdd:COG5021 399 LGQFLFSDF LT SSSTYEDL RR EQL G RE S DE SFY VASNVQQQRA - SREGPLLSGW KT RL N N L YRFYFVEHR KK TLTKNDSR 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 480 fils LG IK IS IMEYE IRRI M E HEAEQA F LISLD K G K SV D V Y FK IKVRRD VISH DS L R C I KEHQ GD L LK S - L R IEFV N E P G 558
Cdd:COG5021 478 ---- LG SF IS LNKLD IRRI K E DKRRKL F YSLKQ K A K IF D P Y LH IKVRRD RVFE DS Y R E I MDES GD D LK K t L E IEFV G E E G 553
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 559 IDAGGL RK EW F FLL T K SL FNP MN GLF I YI K E SSRSWFAIDPPN fdksk GKNSQ L ELYYLF G V V M G L AI FN S T ILD L QF P K 638
Cdd:COG5021 554 IDAGGL TR EW L FLL S K EM FNP DY GLF E YI T E DLYTLPINPLSS ----- INPEH L SYFKFL G R V I G K AI YD S R ILD V QF S K 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 639 A L YKKL CSE P L S FE D YSE L F PE TS R N L IKM LN YTE D NF edvfsl TFET T YRNNNWILND S ksskey V TVEL CE NGRN VPI 718
Cdd:COG5021 629 A F YKKL LGK P V S LV D LES L D PE LY R S L VWL LN NDI D ET ------ ILDL T FTVEDDSFGE S ------ R TVEL IP NGRN ISV 696
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 719 T QS NK H E F V M K W V EFY L E K SI E P Q YNK F V SGF KRVFAEC n SIKL F NSE ELE R L VC G DE E Q tk F D FKSLR S V T K Y V g G FSD 798
Cdd:COG5021 697 T NE NK K E Y V K K V V DYK L N K RV E K Q FSA F K SGF SEIIPPD - LLQI F DES ELE L L IG G IP E D -- I D IDDWK S N T A Y H - G YTE 772
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 799 DS RAVC WFWEII ESW D YPLQK KLLQFVT ASD RIP AT G ISTIPFK ------ ISLL G SH D S D D LP L AHTCFN EIC L WN YSSK 872
Cdd:COG5021 773 DS PIIV WFWEII SEF D FEERA KLLQFVT GTS RIP IN G FKDLQGS dgvrkf TIEK G GT D D D R LP S AHTCFN RLK L PE YSSK 852
890 900
....*....|....*....|
gi 398364915 873 K KL EL KLL W AINE SE G Y G FR 892
Cdd:COG5021 853 E KL RS KLL T AINE GA G F G LL 872
HECTc
cd00078 HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
521-890
1.38e-131
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
Pssm-ID: 238033 [Multi-domain]
Cd Length: 352
Bit Score: 398.09
E-value: 1.38e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 521 F KI K VRRD V I SH D S LR CIKEH - QG DL L K S L RI EFV N E P GIDAGG LRK E W F F L LT K S LFNP MN GLF I Y I k ESSRSWFAID P 599
Cdd:cd00078 1 L KI T VRRD R I LE D A LR QLSKV s SS DL K K V L EV EFV G E E GIDAGG VTR E F F T L VS K E LFNP SY GLF R Y T - PDDSGLLYPN P 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 600 PN F DKSK gkns Q L E L YYLF G VVM G L A IFNSTI LDL Q F PK A L YKKL CSE PLS F ED YS EL F PE TSRN L IKM L NYTE D nf ED V 679
Cdd:cd00078 80 SS F ADED ---- H L K L FRFL G RLL G K A LYEGRL LDL P F SR A F YKKL LGK PLS L ED LE EL D PE LYKS L KEL L DNDG D -- ED D 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 680 FS LTF ETTY rnnnwilnd SK S SKEY VTVEL CEN GR NV P I T QS NK H E F V MKW V EFY L E K S IE P Q YNK F VS GF KR V FA E c NS 759
Cdd:cd00078 154 LE LTF TIEL --------- DS S FGGA VTVEL KPG GR DI P V T NE NK E E Y V DLY V DYR L N K G IE E Q VEA F RD GF SE V IP E - EL 223
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 760 IK LF NS EELE R L V CG D E E qtk F D FKS L RSV T K Y V GG F S D DS RAVC WFWE II ES WDYPLQ KK L LQFVT A S D R I P AT G ISTI 839
Cdd:cd00078 224 LS LF TP EELE L L I CG S E D --- I D LED L KKN T E Y K GG Y S S DS PTIQ WFWE VL ES FTNEER KK F LQFVT G S S R L P VG G FADL 300
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 398364915 840 PF K ISLLGSHDS DD - LP L AHTCFN EIC L WN YSSK KK L EL KLL W AINE SE G Y G 890
Cdd:cd00078 301 NP K FTIRRVGSP DD r LP T AHTCFN LLK L PP YSSK EI L RE KLL Y AINE GA G F G 352
HECTc
smart00119 Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
544-889
1.17e-126
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
Pssm-ID: 214523
Cd Length: 328
Bit Score: 384.66
E-value: 1.17e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 544 DL L K S - L R IEF VN E P G I D A GG LRK E W FFLL T K S LFNP MN GLF I Y IKESS rs WFAID P PNFDKSKGKN S Q lel YYLF G V V M 622
Cdd:smart00119 1 DL K K R v L E IEF EG E E G L D G GG VTR E F FFLL S K E LFNP DY GLF R Y SPNDY -- LLYPN P RSGFANEEHL S Y --- FRFI G R V L 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 623 G L A IFNSTI LDL Q F PKAL YKKL CSE P LSFE D YSE L F PE TSRN L IKM L nytednfedvfs L TFE T TYRNNNWI - LNDSKSS 701
Cdd:smart00119 76 G K A LYDNRL LDL F F ARPF YKKL LGK P VTLH D LES L D PE LYKS L KWL L ------------ L NND T SEELDLTF s IVLTSEF 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 702 KEYVT VEL CEN G R N V P I T QS NK H E F V MKWV E FY L E K S IE P Q YNK F VS GF KR V FA E c N SI KLF NS EELE R L V CG DE E QTKF 781
Cdd:smart00119 144 GQVKV VEL KPG G S N I P V T EE NK K E Y V HLVI E YR L N K G IE K Q LEA F RE GF SE V IP E - N LL KLF DP EELE L L I CG SP E IDVD 222
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 782 D fks L R S V T K Y V GG F S DD S RAVC WFWE II ES WDYPLQK KLLQFVT A S D R I P AT G ISTIPF K ISLLGSH - D SDD LP L AHTC 860
Cdd:smart00119 223 D --- L K S N T E Y K GG Y S AN S QTIK WFWE VV ES FTNEERR KLLQFVT G S S R L P VG G FAALSP K FTIRKAG s D DER LP T AHTC 299
330 340
....*....|....*....|....*....
gi 398364915 861 FN EIC L WN YSSK KK L EL KLL W AINE SE G Y 889
Cdd:smart00119 300 FN RLK L PP YSSK EI L RE KLL L AINE GK G F 328
HECT
pfam00632 HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
570-892
1.37e-92
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.
Pssm-ID: 459880
Cd Length: 304
Bit Score: 294.52
E-value: 1.37e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 570 F LL T K S LF N P MN GLF I Y IK E SS R S wfa IDPPNFDKSKGKNSQ L ELYYLF G VVM G L AI F N STI LDL Q FP KAL YKKL CS EPL 649
Cdd:pfam00632 1 T LL S K E LF D P NY GLF E Y ET E DD R T --- YWFNPSSSESPDLEL L DYFKFL G KLL G K AI Y N GIL LDL P FP PFF YKKL LG EPL 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 650 SF ED YSELF PE TSRN L IKM LN YTE D NF ED v FS LTF ETTY rnnnwilndsks SK E YV T V EL CE NGRN V P I T QS NK H E FVMK 729
Cdd:pfam00632 78 TL ED LESID PE LYKS L KSL LN MDN D DD ED - LG LTF TIPV ------------ FG E SK T I EL IP NGRN I P V T NE NK E E YIRL 144
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 730 W V EFY L E KSIEPQ YNK F VS GF KR V FAE c NSIK LF NS EELE R L V CG DE E qtk F D FKS L RSV T K Y V GG FSDD S RAVC WFWEI 809
Cdd:pfam00632 145 Y V DYR L N KSIEPQ LEA F RK GF YS V IPK - EALS LF TP EELE L L I CG SP E --- I D VED L KKN T E Y D GG YTKN S PTIQ WFWEI 220
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364915 810 I E SWDYPLQKKL L Q FVT A S D R I P AT G ISTI P - F K I SLL G SH D S D D LP L AHTCFN EIC L WN YSSK KK L EL KLL W AI N E S EG 888
Cdd:pfam00632 221 L E EFSPEQRRLF L K FVT G S S R L P VG G FKSL P k F T I VRK G GD D D D R LP T AHTCFN RLK L PD YSSK EI L KE KLL I AI E E G EG 300
....
gi 398364915 889 Y G FR 892
Cdd:pfam00632 301 F G LS 304
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
