NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|398366275|ref|NP_011760|]
View 

succinate--CoA ligase (GDP-forming) subunit beta [Saccharomyces cerevisiae S288C]

Protein Classification

succinate--CoA ligase subunit beta( domain architecture ID 11414565)

ADP/GDP-forming succinate--CoA ligase subunit beta provides nucleotide specificity and binds the succinate substrate for the succinate--CoA ligase enzyme, which functions in the citric acid cycle (TCA) by coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP

CATH:  3.40.50.261
EC:  6.2.1.-
Gene Ontology:  GO:0004774|GO:0000287|GO:0000166|GO:0006099|GO:0042709
PubMed:  3332988

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SucC COG0045
Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA ...
 33-427 0e+00

Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA synthetase, beta subunit is part of the Pathway/BioSystem: TCA cycle


:

Pssm-ID: 439815 [Multi-domain]  Cd Length: 388  Bit Score: 572.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  33 IHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGhfdtGyksGVHMIESPQQAEDVAKE 112
Cdd:COG0045    3 LHEYQAKELLAKYGVPVPRGIVATTPEEAVAAAEELGGPPVVVKAQVHAGGRGKA----G---GVKLAKSPEEAREAAEE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 113 MLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSKGL 192
Cdd:COG0045   76 ILGMTLVTHQTGPKGKPVNKVLVEEGVDIAKELYLSILLDRATRRPVIMASTEGGMDIEEVAEETPEKIIKVPIDPLVGL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 193 SPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSEiehDPTHKIMCTDAKFGFDDNASFRQEKIYSW 272
Cdd:COG0045  156 QPYQARELAFALGLPGKQVKQFAKILKKLYRAFVEKDASLVEINPLVV---TKDGRLVALDAKVNFDDNALFRHPELAAL 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 273 RDLSQEDPDEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVIKLNGGDPANFLDCGGGATPETIKQGFELILSNKNVD 352
Cdd:COG0045  233 RDLSEEDPLEVEASKYGLNYVKLDGNIGCMVNGAGLAMATMDIIKLAGGEPANFLDVGGGATAERVAEAFKIILSDPNVK 312

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366275 353 AIFVNIFGGIVRCDYVALGLVEAARELEVRVPIVARLQGTKVEEGRDIINKSGVKIYSFDELDPAAKKVVELTQN 427
Cdd:COG0045  313 AILVNIFGGITRCDVVAEGIVAALKEVGLKVPVVVRLEGTNVEEGRKILAESGLNIIAADTLEEAAKKAVELAKG 387
 
Name Accession Description Interval E-value
SucC COG0045
Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA ...
 33-427 0e+00

Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA synthetase, beta subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439815 [Multi-domain]  Cd Length: 388  Bit Score: 572.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  33 IHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGhfdtGyksGVHMIESPQQAEDVAKE 112
Cdd:COG0045    3 LHEYQAKELLAKYGVPVPRGIVATTPEEAVAAAEELGGPPVVVKAQVHAGGRGKA----G---GVKLAKSPEEAREAAEE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 113 MLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSKGL 192
Cdd:COG0045   76 ILGMTLVTHQTGPKGKPVNKVLVEEGVDIAKELYLSILLDRATRRPVIMASTEGGMDIEEVAEETPEKIIKVPIDPLVGL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 193 SPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSEiehDPTHKIMCTDAKFGFDDNASFRQEKIYSW 272
Cdd:COG0045  156 QPYQARELAFALGLPGKQVKQFAKILKKLYRAFVEKDASLVEINPLVV---TKDGRLVALDAKVNFDDNALFRHPELAAL 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 273 RDLSQEDPDEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVIKLNGGDPANFLDCGGGATPETIKQGFELILSNKNVD 352
Cdd:COG0045  233 RDLSEEDPLEVEASKYGLNYVKLDGNIGCMVNGAGLAMATMDIIKLAGGEPANFLDVGGGATAERVAEAFKIILSDPNVK 312

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366275 353 AIFVNIFGGIVRCDYVALGLVEAARELEVRVPIVARLQGTKVEEGRDIINKSGVKIYSFDELDPAAKKVVELTQN 427
Cdd:COG0045  313 AILVNIFGGITRCDVVAEGIVAALKEVGLKVPVVVRLEGTNVEEGRKILAESGLNIIAADTLEEAAKKAVELAKG 387
sucC PRK00696
ADP-forming succinate--CoA ligase subunit beta;
33-424 0e+00

ADP-forming succinate--CoA ligase subunit beta;


Pssm-ID: 234813 [Multi-domain]  Cd Length: 388  Bit Score: 550.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  33 IHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGhfdtgykSGVHMIESPQQAEDVAKE 112
Cdd:PRK00696   3 LHEYQAKELFAKYGVPVPRGIVATTPEEAVEAAEELGGGVWVVKAQVHAGGRGKA-------GGVKLAKSPEEAREFAKQ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 113 MLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSKGL 192
Cdd:PRK00696  76 ILGMTLVTHQTGPKGQPVNKVLVEEGADIAKEYYLSIVLDRATRRVVFMASTEGGMDIEEVAEETPEKIHKVAIDPLTGL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 193 SPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSEIEHDpthKIMCTDAKFGFDDNASFRQEKIYSW 272
Cdd:PRK00696 156 QPFQAREIAFKLGLPGEQVKQFAKILMGLYKAFVEKDASLVEINPLVVTKDG---DLIALDAKINFDDNALFRHPDLAEL 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 273 RDLSQEDPDEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVIKLNGGDPANFLDCGGGATPETIKQGFELILSNKNVD 352
Cdd:PRK00696 233 RDLSEEDPLEAEASKYGLNYVKLDGNIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGGGATAERVAEAFKIILSDPNVK 312

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398366275 353 AIFVNIFGGIVRCDYVALGLVEAARELEVRVPIVARLQGTKVEEGRDIINKSGVKIYSFDELDPAAKKVVEL 424
Cdd:PRK00696 313 AILVNIFGGITRCDVIAEGIIAAVKEVGVTVPLVVRLEGTNVELGKKILAESGLNIIAADTLDDAAQKAVEA 384
sucCoAbeta TIGR01016
succinyl-CoA synthetase, beta subunit; This model is designated subfamily because it does not ...
 33-424 1.56e-152

succinyl-CoA synthetase, beta subunit; This model is designated subfamily because it does not discriminate the ADP-forming enzyme ((EC 6.2.1.5) from the GDP_forming (EC 6.2.1.4) enzyme. The N-terminal half is described by the CoA-ligases model (pfam00549). The C-terminal half is described by the ATP-grasp model (pfam02222). This family contains a split seen both in a maximum parsimony tree (which ignores gaps) and in the gap pattern near position 85 of the seed alignment. Eukaryotic and most bacterial sequences are longer and contain a region similar to TXQTXXXG. Sequences from Deinococcus radiodurans, Mycobacterium tuberculosis, Streptomyces coelicolor, and the Archaea are 6 amino acids shorter in that region and contain a motif resembling [KR]G [Energy metabolism, TCA cycle]


Pssm-ID: 273396 [Multi-domain]  Cd Length: 386  Bit Score: 437.20  E-value: 1.56e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275   33 IHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGhfdtgykSGVHMIESPQQAEDVAKE 112
Cdd:TIGR01016   3 LHEYQAKQIFAKYGIPVPRGYVATSVEEAEEIAAKLGAGPVVVKAQVHAGGRGKA-------GGVKVAKSKEEARAAAEK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  113 MLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSKGL 192
Cdd:TIGR01016  76 LLGKELVTNQTDPLGQPVNKILIEEATDIDKEYYLSIVIDRSARCPVIMASTEGGVDIEEVAEKSPEKIIKYAIDPLTGL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  193 SPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSEiehDPTHKIMCTDAKFGFDDNASFRQEKIYSW 272
Cdd:TIGR01016 156 LPYQAREIAKKLGLEGELVKQVADIIKKLYQIFLEYDASLVEINPLVI---TKDGNLIALDAKLTIDDNALFRHPDLEEM 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  273 RDLSQEDPDEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVIKLNGGDPANFLDCGGGATPETIKQGFELILSNKNVD 352
Cdd:TIGR01016 233 RDYSQEDPREVLAKQWGLNYVALDGNIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGGGASAERVREALKLVLSDKSVK 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398366275  353 AIFVNIFGGIVRCDYVALGLVEAARELEVRVPIVARLQGTKVEEGRDIINKSGVKIYSFDELDPAAKKVVEL 424
Cdd:TIGR01016 313 VVFINIFGGITRCDLVAKGLVEALKEVGVNVPVVVRLEGTNVEEGKKILAESGLNIIFATSMEEAAEKAVEA 384
ATP-grasp_2 pfam08442
ATP-grasp domain;
32-240 6.84e-104

ATP-grasp domain;


Pssm-ID: 400651 [Multi-domain]  Cd Length: 202  Bit Score: 306.49  E-value: 6.84e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275   32 SIHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGhfdtgykSGVHMIESPQQAEDVAK 111
Cdd:pfam08442   1 NLHEYQAKEIFAKYGIPVPRGEVATSPEEAEEIAKKLGGKVYVVKAQVLAGGRGKA-------GGVKLAKSPEEAKEVAK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  112 EMLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSKG 191
Cdd:pfam08442  74 EMLGKNLVTKQTGPDGQPVNKVLVEEALDIKKEYYLSIVLDRASKGPVIIASTEGGVDIEEVAAKNPEKIHKFPIDPLKG 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 398366275  192 LSPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSE 240
Cdd:pfam08442 154 LTPYQAREIAFKLGLPGELIKQAADIIKKLYKLFVEYDATLVEINPLVE 202
 
Name Accession Description Interval E-value
SucC COG0045
Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA ...
 33-427 0e+00

Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA synthetase, beta subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439815 [Multi-domain]  Cd Length: 388  Bit Score: 572.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  33 IHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGhfdtGyksGVHMIESPQQAEDVAKE 112
Cdd:COG0045    3 LHEYQAKELLAKYGVPVPRGIVATTPEEAVAAAEELGGPPVVVKAQVHAGGRGKA----G---GVKLAKSPEEAREAAEE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 113 MLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSKGL 192
Cdd:COG0045   76 ILGMTLVTHQTGPKGKPVNKVLVEEGVDIAKELYLSILLDRATRRPVIMASTEGGMDIEEVAEETPEKIIKVPIDPLVGL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 193 SPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSEiehDPTHKIMCTDAKFGFDDNASFRQEKIYSW 272
Cdd:COG0045  156 QPYQARELAFALGLPGKQVKQFAKILKKLYRAFVEKDASLVEINPLVV---TKDGRLVALDAKVNFDDNALFRHPELAAL 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 273 RDLSQEDPDEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVIKLNGGDPANFLDCGGGATPETIKQGFELILSNKNVD 352
Cdd:COG0045  233 RDLSEEDPLEVEASKYGLNYVKLDGNIGCMVNGAGLAMATMDIIKLAGGEPANFLDVGGGATAERVAEAFKIILSDPNVK 312

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366275 353 AIFVNIFGGIVRCDYVALGLVEAARELEVRVPIVARLQGTKVEEGRDIINKSGVKIYSFDELDPAAKKVVELTQN 427
Cdd:COG0045  313 AILVNIFGGITRCDVVAEGIVAALKEVGLKVPVVVRLEGTNVEEGRKILAESGLNIIAADTLEEAAKKAVELAKG 387
sucC PRK00696
ADP-forming succinate--CoA ligase subunit beta;
33-424 0e+00

ADP-forming succinate--CoA ligase subunit beta;


Pssm-ID: 234813 [Multi-domain]  Cd Length: 388  Bit Score: 550.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  33 IHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGhfdtgykSGVHMIESPQQAEDVAKE 112
Cdd:PRK00696   3 LHEYQAKELFAKYGVPVPRGIVATTPEEAVEAAEELGGGVWVVKAQVHAGGRGKA-------GGVKLAKSPEEAREFAKQ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 113 MLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSKGL 192
Cdd:PRK00696  76 ILGMTLVTHQTGPKGQPVNKVLVEEGADIAKEYYLSIVLDRATRRVVFMASTEGGMDIEEVAEETPEKIHKVAIDPLTGL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 193 SPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSEIEHDpthKIMCTDAKFGFDDNASFRQEKIYSW 272
Cdd:PRK00696 156 QPFQAREIAFKLGLPGEQVKQFAKILMGLYKAFVEKDASLVEINPLVVTKDG---DLIALDAKINFDDNALFRHPDLAEL 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 273 RDLSQEDPDEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVIKLNGGDPANFLDCGGGATPETIKQGFELILSNKNVD 352
Cdd:PRK00696 233 RDLSEEDPLEAEASKYGLNYVKLDGNIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGGGATAERVAEAFKIILSDPNVK 312

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398366275 353 AIFVNIFGGIVRCDYVALGLVEAARELEVRVPIVARLQGTKVEEGRDIINKSGVKIYSFDELDPAAKKVVEL 424
Cdd:PRK00696 313 AILVNIFGGITRCDVIAEGIIAAVKEVGVTVPLVVRLEGTNVELGKKILAESGLNIIAADTLDDAAQKAVEA 384
PLN00124 PLN00124
succinyl-CoA ligase [GDP-forming] subunit beta; Provisional
 13-422 3.63e-167

succinyl-CoA ligase [GDP-forming] subunit beta; Provisional


Pssm-ID: 177736 [Multi-domain]  Cd Length: 422  Bit Score: 475.78  E-value: 3.63e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  13 CGQLSRLNAQAALQARRHLSIHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNK--LVIKAQALTGGRGKGHFD 90
Cdd:PLN00124  10 ASRSLSVAGKWQHQQLRRLNIHEYQGAELMSKYGVNVPKGAAASSLDEVKKALEKMFPDEgeVVVKSQILAGGRGLGTFK 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  91 TGYKSGVHMIESpQQAEDVAKEMLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNI 170
Cdd:PLN00124  90 NGLKGGVHIVKK-DKAEELAGKMLGQILVTKQTGPAGKPVNKVYLCEKMSLVNEMYFAILLDRASAGPLIIACSKGGTSI 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 171 EEVAERTPDAIKKFSIETSKGLSPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSEiehDPTHKIM 250
Cdd:PLN00124 169 EDLAEKFPEKIIKVPIDIFKGITDEDAAKVVDGLAPKVADRNDAIEQVKKLYKLFCKCDCTMVEINPLAE---TADGQLV 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 251 CTDAKFGFDDNASFRQEKIYSWRDLSQEDPDEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVIKLNGGDPANFLDCG 330
Cdd:PLN00124 246 AADAKLNFDDNAAFRQKEIFALRDTSQEDPREVAAAKADLNYIGLDGEIGCMVNGAGLAMATMDIIKLHGGSPANFLDVG 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 331 GGATPETIKQGFELILSNKNVDAIFVNIFGGIVRCDYVALGLVEAARELEVRVPIVARLQGTKVEEGRDIINKSGVKIYS 410
Cdd:PLN00124 326 GNASEQQVVEAFKILTSDDKVKAILVNIFGGIMKCDVIASGIVNAAKQVGLKVPLVVRLEGTNVDQGKRILKESGMTLIT 405

                        410
                 ....*....|..
gi 398366275 411 FDELDPAAKKVV 422
Cdd:PLN00124 406 AEDLDDAAEKAV 417
sucCoAbeta TIGR01016
succinyl-CoA synthetase, beta subunit; This model is designated subfamily because it does not ...
 33-424 1.56e-152

succinyl-CoA synthetase, beta subunit; This model is designated subfamily because it does not discriminate the ADP-forming enzyme ((EC 6.2.1.5) from the GDP_forming (EC 6.2.1.4) enzyme. The N-terminal half is described by the CoA-ligases model (pfam00549). The C-terminal half is described by the ATP-grasp model (pfam02222). This family contains a split seen both in a maximum parsimony tree (which ignores gaps) and in the gap pattern near position 85 of the seed alignment. Eukaryotic and most bacterial sequences are longer and contain a region similar to TXQTXXXG. Sequences from Deinococcus radiodurans, Mycobacterium tuberculosis, Streptomyces coelicolor, and the Archaea are 6 amino acids shorter in that region and contain a motif resembling [KR]G [Energy metabolism, TCA cycle]


Pssm-ID: 273396 [Multi-domain]  Cd Length: 386  Bit Score: 437.20  E-value: 1.56e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275   33 IHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGhfdtgykSGVHMIESPQQAEDVAKE 112
Cdd:TIGR01016   3 LHEYQAKQIFAKYGIPVPRGYVATSVEEAEEIAAKLGAGPVVVKAQVHAGGRGKA-------GGVKVAKSKEEARAAAEK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  113 MLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSKGL 192
Cdd:TIGR01016  76 LLGKELVTNQTDPLGQPVNKILIEEATDIDKEYYLSIVIDRSARCPVIMASTEGGVDIEEVAEKSPEKIIKYAIDPLTGL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  193 SPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSEiehDPTHKIMCTDAKFGFDDNASFRQEKIYSW 272
Cdd:TIGR01016 156 LPYQAREIAKKLGLEGELVKQVADIIKKLYQIFLEYDASLVEINPLVI---TKDGNLIALDAKLTIDDNALFRHPDLEEM 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  273 RDLSQEDPDEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVIKLNGGDPANFLDCGGGATPETIKQGFELILSNKNVD 352
Cdd:TIGR01016 233 RDYSQEDPREVLAKQWGLNYVALDGNIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGGGASAERVREALKLVLSDKSVK 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398366275  353 AIFVNIFGGIVRCDYVALGLVEAARELEVRVPIVARLQGTKVEEGRDIINKSGVKIYSFDELDPAAKKVVEL 424
Cdd:TIGR01016 313 VVFINIFGGITRCDLVAKGLVEALKEVGVNVPVVVRLEGTNVEEGKKILAESGLNIIFATSMEEAAEKAVEA 384
PRK14046 PRK14046
malate--CoA ligase subunit beta; Provisional
 31-427 9.97e-147

malate--CoA ligase subunit beta; Provisional


Pssm-ID: 237594 [Multi-domain]  Cd Length: 392  Bit Score: 422.58  E-value: 9.97e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  31 LSIHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGhfdtgykSGVHMIESPQQAEDVA 110
Cdd:PRK14046   1 MDIHEYQAKELLASFGVAVPRGALAYSPEQAVYRARELGGWHWVVKAQIHSGARGKA-------GGIKLCRTYNEVRDAA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 111 KEMLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSK 190
Cdd:PRK14046  74 EDLLGKKLVTHQTGPEGKPVQRVYVETADPIERELYLGFVLDRKSERVRVIASARGGMEIEEIAAKEPEAIIQVVVEPAV 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 191 GLSPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSEIEHDpthKIMCTDAKFGFDDNASFRQEKIY 270
Cdd:PRK14046 154 GLQQFQAREIAFGLGLDIKQVSRAVKTIMGCYRAFRDLDATMLEINPLVVTKDD---RVLALDAKMSFDDNALFRRPNIA 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 271 SWRDLSQEDPDEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVIKLNGGDPANFLDCGGGATPETIKQGFELILSNKN 350
Cdd:PRK14046 231 EMRDPSQEDPREAQAAEHGLSYVGLDGDIGCIVNGAGLAMATMDMIKLAGGEPANFLDVGGGASPERVAKAFRLVLSDRN 310

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 398366275 351 VDAIFVNIFGGIVRCDYVALGLVEAARELEVRVPIVARLQGTKVEEGRDIINKSGVKIYSFDELDPAAKKVVELTQN 427
Cdd:PRK14046 311 VKAILVNIFAGINRCDWVAEGVVQAAREVGIDVPLVVRLAGTNVEEGRKILAESGLPIITADTLAEAAEKAVEAWKG 387
ATP-grasp_2 pfam08442
ATP-grasp domain;
32-240 6.84e-104

ATP-grasp domain;


Pssm-ID: 400651 [Multi-domain]  Cd Length: 202  Bit Score: 306.49  E-value: 6.84e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275   32 SIHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGhfdtgykSGVHMIESPQQAEDVAK 111
Cdd:pfam08442   1 NLHEYQAKEIFAKYGIPVPRGEVATSPEEAEEIAKKLGGKVYVVKAQVLAGGRGKA-------GGVKLAKSPEEAKEVAK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  112 EMLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSKG 191
Cdd:pfam08442  74 EMLGKNLVTKQTGPDGQPVNKVLVEEALDIKKEYYLSIVLDRASKGPVIIASTEGGVDIEEVAAKNPEKIHKFPIDPLKG 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 398366275  192 LSPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSE 240
Cdd:pfam08442 154 LTPYQAREIAFKLGLPGELIKQAADIIKKLYKLFVEYDATLVEINPLVE 202
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 302-422 2.59e-39

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 137.39  E-value: 2.59e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  302 LVNGAGLAMATMDVIKLNGGDPANFLDCGGGA-TPETIKQGFELILSNKNVDAIFVNIFGGIVRCDYVALGLVEAARELE 380
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAfTPTTRIDALKLEAADPEVKVILLDIVLGYGACEDPAGGLLKAIKEAR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 398366275  381 VR-VPIVARLQGTKVE-----EGRDIINKSGVKIYSFDELDPAAKKVV 422
Cdd:pfam00549  81 AReLPVVARVCGTEADpqgrsGQAKALAESGVLIASSNNQALRAAGAV 128
PLN02235 PLN02235
ATP citrate (pro-S)-lyase
 27-316 1.02e-07

ATP citrate (pro-S)-lyase


Pssm-ID: 177879 [Multi-domain]  Cd Length: 423  Bit Score: 53.62  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  27 ARRhlSIHEYRSAQLLREY-----GIGTPEGFPAFTPEEAF-EAAKK---LNTNKLVIKAQALTGGRGkghfdtgyKSG- 96
Cdd:PLN02235   2 ARK--KIREYDSKRLLKEHlkrlaGIDLPIRSAQVTESTDFnELANKepwLSSTKLVVKPDMLFGKRG--------KSGl 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  97 VHMIESPQQAEDVAKEMLNHNLitKQTGIAGkPVSAVYIVKRVDTKHEAYLSILMDRQTKKpmIIASSQGGMNIEEvaer 176
Cdd:PLN02235  72 VALNLDLAQVATFVKERLGKEV--EMGGCKG-PITTFIVEPFVPHDQEFYLSIVSDRLGCS--ISFSECGGIEIEE---- 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275 177 TPDAIKKFSIETSKGLSPQMAKDVAKSLGFspDAQDEAAKAVSNLYKIFMERDATQVEINPLSEIEHDPthkiMCTDAKF 256
Cdd:PLN02235 143 NWDKVKTIFLPTEAPLTSEICAPLIATLPL--EIRGKIEEFIKGVFAVFQDLDFTFLEMNPFTLVDGEP----YPLDMRG 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366275 257 GFDDNASFRQEKiySWRDLSQEDP---------------DEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVI 316
Cdd:PLN02235 217 ELDDTAAFKNFK--KWGNIEFPLPfgrvmsptesfihglDEKTSASLKFTVLNPKGRIWTMVAGGGASVIYADTV 289
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
22-114 2.13e-05

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 46.66  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  22 QAALQARRHlSIHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTnKLVIKAQA--LTggrgkgHfdtgyKS---G 96
Cdd:COG1042  478 EAALAEGRG-VLTEAEAKALLAAYGIPVVPTRLARSAEEAVAAAEEIGY-PVVLKIVSpdIL------H-----KSdvgG 544

                         90
                 ....*....|....*....
gi 398366275  97 VHM-IESPQQAEDVAKEML 114
Cdd:COG1042  545 VRLnLRDAEAVRAAFEEIL 563
GARS_A pfam01071
Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide ...
 38-130 1.07e-04

Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase catalyzes the second step in the de novo biosynthesis of purine. The reaction catalyzed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the ATP-grasp domain of biotin carboxylase/carbamoyl phosphate synthetase (see pfam02786).


Pssm-ID: 395851 [Multi-domain]  Cd Length: 194  Bit Score: 43.04  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275   38 SAQLLREYGIGTPEGFpAFT-PEEAFEAAKKLNTNKLVIKAQALTGGRgkghfdtgyksGVHMIESPQQAEDVAKEMLNh 116
Cdd:pfam01071   6 AKDFMKRYGIPTAEYE-TFTdPEEAKSYIQEAGFPAIVVKADGLAAGK-----------GVIVASSNEEAIKAVDEILE- 72

                          90
                  ....*....|....
gi 398366275  117 nliTKQTGIAGKPV 130
Cdd:pfam01071  73 ---QKKFGEAGETV 83
ATP-grasp_5 pfam13549
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 23-115 1.58e-04

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 463918 [Multi-domain]  Cd Length: 221  Bit Score: 42.85  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275   23 AALQARRH-LSihEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTnKLVIKAQA--LTggrgkghfdtgYKS---G 96
Cdd:pfam13549   1 KALAEGRTvLT--EPEAKALLAAYGIPVVPTRLARSPEEAVAAAEEIGY-PVVLKIVSpdIL-----------HKSdvgG 66

                          90       100
                  ....*....|....*....|
gi 398366275   97 VHM-IESPQQAEDVAKEMLN 115
Cdd:pfam13549  67 VRLnLRSAEAVRAAYEEILE 86
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 36-161 9.70e-04

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 40.63  E-value: 9.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366275  36 YRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTnKLVIKAQALTGGRgkghfdtgyksGVHMIESPQQAEDVAKEMLN 115
Cdd:COG0439   56 VLMREALAAAGVPVPGFALVDSPEEALAFAEEIGY-PVVVKPADGAGSR-----------GVRVVRDEEELEAALAEARA 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 398366275 116 HNlitkqtgIAGKPVSAVYIVKRVDTKH----------EAYLSILMDRQTKKPMII 161
Cdd:COG0439  124 EA-------KAGSPNGEVLVEEFLEGREysveglvrdgEVVVCSITRKHQKPPYFV 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH