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Conserved domains on  [gi|48762937|ref|NP_009124|]
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annexin A10 [Homo sapiens]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 93-158 4.56e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 92.92  E-value: 4.56e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48762937    93 YDAHELWHAMKGVGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 251-316 1.20e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 86.37  E-value: 1.20e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48762937   251 YFAYRLYSAIHDFGFHNKTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 316
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-86 2.37e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.82  E-value: 2.37e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48762937    22 DAQMLGGALQGFDCDKDMLINILTQRCNAQRMMIAEAYQSMYGRDLIGDMREQLSDHFKDVMAGL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 175-241 7.42e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 7.42e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 48762937   175 QDAMVLWEACQqKTGEHKTMLQMILCNKSYQQLRLVFQEFQNISGQDMVDAINECYDGYFQELLVAI 241
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 93-158 4.56e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 92.92  E-value: 4.56e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48762937    93 YDAHELWHAMKGVGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 251-316 1.20e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 86.37  E-value: 1.20e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48762937   251 YFAYRLYSAIHDFGFHNKTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 316
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-86 2.37e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.82  E-value: 2.37e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48762937    22 DAQMLGGALQGFDCDKDMLINILTQRCNAQRMMIAEAYQSMYGRDLIGDMREQLSDHFKDVMAGL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 175-241 7.42e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 7.42e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 48762937   175 QDAMVLWEACQqKTGEHKTMLQMILCNKSYQQLRLVFQEFQNISGQDMVDAINECYDGYFQELLVAI 241
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
268-316 5.08e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 68.20  E-value: 5.08e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 48762937    268 KTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 316
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
106-158 2.50e-14

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 66.28  E-value: 2.50e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 48762937    106 GTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
36-86 4.80e-11

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 57.03  E-value: 4.80e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 48762937     36 DKDMLINILTQRCNAQRMMIAEAYQSMYGRDLIGDMREQLSDHFKDVMAGL 86
Cdd:smart00335   3 DEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
198-241 2.34e-06

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 43.94  E-value: 2.34e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 48762937    198 ILCNKSYQQLRLVFQEFQNISGQDMVDAINECYDGYFQELLVAI 241
Cdd:smart00335  10 ILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 93-158 4.56e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 92.92  E-value: 4.56e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48762937    93 YDAHELWHAMKGVGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 251-316 1.20e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 86.37  E-value: 1.20e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48762937   251 YFAYRLYSAIHDFGFHNKTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 316
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-86 2.37e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.82  E-value: 2.37e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48762937    22 DAQMLGGALQGFDCDKDMLINILTQRCNAQRMMIAEAYQSMYGRDLIGDMREQLSDHFKDVMAGL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 175-241 7.42e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 7.42e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 48762937   175 QDAMVLWEACQqKTGEHKTMLQMILCNKSYQQLRLVFQEFQNISGQDMVDAINECYDGYFQELLVAI 241
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
268-316 5.08e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 68.20  E-value: 5.08e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 48762937    268 KTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 316
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
106-158 2.50e-14

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 66.28  E-value: 2.50e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 48762937    106 GTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
36-86 4.80e-11

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 57.03  E-value: 4.80e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 48762937     36 DKDMLINILTQRCNAQRMMIAEAYQSMYGRDLIGDMREQLSDHFKDVMAGL 86
Cdd:smart00335   3 DEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
198-241 2.34e-06

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 43.94  E-value: 2.34e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 48762937    198 ILCNKSYQQLRLVFQEFQNISGQDMVDAINECYDGYFQELLVAI 241
Cdd:smart00335  10 ILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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