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Conserved domains on  [gi|6005920|ref|NP_009048|]
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thyrotropin releasing hormone preproprotein [Homo sapiens]

Protein Classification

TRH domain-containing protein( domain architecture ID 10527181)

TRH domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRH pfam05438
Thyrotropin-releasing hormone (TRH); This family consists of several thyrotropin-releasing ...
 18-202 1.06e-48

Thyrotropin-releasing hormone (TRH); This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localized on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.


:

Pssm-ID: 461653 [Multi-domain]  Cd Length: 220  Bit Score: 159.58  E-value: 1.06e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005920     18 GVPGGRAQPEAAQQEAVTaaehpGLDDFLRQVERLLfLRENIQRLQGDQGEHSaSQIFQSDWLSKRQHPGKREEE----E 93
Cdd:pfam05438  13 TVNGGQSIPEEDEQDGRS-----PLDDILQRAESLL-LRSILKKLQDEDGRND-GESSQPEWLSKRQHPGKRYEEdlekR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005920     94 EEGVEEEEEEEGGAVGPHKRQHPGRREDEAsWSVDVTQHKRQHPGRRS-------PWLAYA--VPKRQHPGRRL----AD 160
Cdd:pfam05438  86 QHPGRREEEEEESYGDIQKRQHPGKREDEA-WDSYLELQKRQHPGRRSlldqfsdNPLGYLseLSKRQHPGRRYlmskRQ 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 6005920    161 PKAQRSWEEEEEEEEREEDLMPEKRQHPGKRA-------LGGPCGPQGA 202
Cdd:pfam05438 165 HPGKRSWEDEDEELDEEDLLELEKRQHPGKRFwdnsspdLGSPCDVLDP 213
 
Name Accession Description Interval E-value
TRH pfam05438
Thyrotropin-releasing hormone (TRH); This family consists of several thyrotropin-releasing ...
 18-202 1.06e-48

Thyrotropin-releasing hormone (TRH); This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localized on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.


Pssm-ID: 461653 [Multi-domain]  Cd Length: 220  Bit Score: 159.58  E-value: 1.06e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005920     18 GVPGGRAQPEAAQQEAVTaaehpGLDDFLRQVERLLfLRENIQRLQGDQGEHSaSQIFQSDWLSKRQHPGKREEE----E 93
Cdd:pfam05438  13 TVNGGQSIPEEDEQDGRS-----PLDDILQRAESLL-LRSILKKLQDEDGRND-GESSQPEWLSKRQHPGKRYEEdlekR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005920     94 EEGVEEEEEEEGGAVGPHKRQHPGRREDEAsWSVDVTQHKRQHPGRRS-------PWLAYA--VPKRQHPGRRL----AD 160
Cdd:pfam05438  86 QHPGRREEEEEESYGDIQKRQHPGKREDEA-WDSYLELQKRQHPGRRSlldqfsdNPLGYLseLSKRQHPGRRYlmskRQ 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 6005920    161 PKAQRSWEEEEEEEEREEDLMPEKRQHPGKRA-------LGGPCGPQGA 202
Cdd:pfam05438 165 HPGKRSWEDEDEELDEEDLLELEKRQHPGKRFwdnsspdLGSPCDVLDP 213
 
Name Accession Description Interval E-value
TRH pfam05438
Thyrotropin-releasing hormone (TRH); This family consists of several thyrotropin-releasing ...
 18-202 1.06e-48

Thyrotropin-releasing hormone (TRH); This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localized on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.


Pssm-ID: 461653 [Multi-domain]  Cd Length: 220  Bit Score: 159.58  E-value: 1.06e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005920     18 GVPGGRAQPEAAQQEAVTaaehpGLDDFLRQVERLLfLRENIQRLQGDQGEHSaSQIFQSDWLSKRQHPGKREEE----E 93
Cdd:pfam05438  13 TVNGGQSIPEEDEQDGRS-----PLDDILQRAESLL-LRSILKKLQDEDGRND-GESSQPEWLSKRQHPGKRYEEdlekR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005920     94 EEGVEEEEEEEGGAVGPHKRQHPGRREDEAsWSVDVTQHKRQHPGRRS-------PWLAYA--VPKRQHPGRRL----AD 160
Cdd:pfam05438  86 QHPGRREEEEEESYGDIQKRQHPGKREDEA-WDSYLELQKRQHPGRRSlldqfsdNPLGYLseLSKRQHPGRRYlmskRQ 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 6005920    161 PKAQRSWEEEEEEEEREEDLMPEKRQHPGKRA-------LGGPCGPQGA 202
Cdd:pfam05438 165 HPGKRSWEDEDEELDEEDLLELEKRQHPGKRFwdnsspdLGSPCDVLDP 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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