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Conserved domains on  [gi|148596994|ref|NP_008916|]
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nuclear pore complex-interacting protein family member A1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPIP super family cl05750
Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate ...
 1-267 9.76e-154

Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans.


The actual alignment was detected with superfamily member pfam06409:

Pssm-ID: 461900 [Multi-domain]  Cd Length: 267  Bit Score: 432.63  E-value: 9.76e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148596994    1 MFCCLGYEWLSGGCKTWHSAWVINTLADHRHRGTDFGGSPWLLIITVFLRSYKFAISLCTSYLCVSFLKTIFPSQNGHDG 80
Cdd:pfam06409   1 MFCCLADERHRGGCFGGHPALLIITLADHRHKFADFGCSPWLCIIFLFLIFPKFAGHDCSSDLCQRALKSIFPRQEGHDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148596994   81 STDVQQRARRSNRRRQEGIKIVLEDIFTLWRQVETKVRAKIRKMKVTTKVNRHDKINGKRKTAKEHLRKLSMKEREHGEK 160
Cdd:pfam06409  81 SLDDIFRARRQNERKQEAIICKLEDIFKLNRHDEIKGKAKIAKEHLRKKSMKEDEHGEKEKQAKEAEEKGKLDEKEHGEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148596994  161 ERQVSEAEENGKLDMKEIHTYMEMFQRAQALRRRAEDYYRCKITPSARKPLCNRVRMAAVEHRHSSGLPYWPYLTAETLK 240
Cdd:pfam06409 161 EEMFQEAEALGKLAEDEIHCKIEMFARAPACNRRAEAAAECKHSPGAPKPLCLRAEMAAAEHGHQPGLPTQPHLIADNLK 240

                         250       260
                  ....*....|....*....|....*..
gi 148596994  241 NRMGHQPPPPTQQHSIIDNSLSLKTPS 267
Cdd:pfam06409 241 NLKGHPECLLTPLHPIADNSADDKLKP 267
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 246-346 3.77e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.37  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148596994  246 QPPPPTQQHSIIDNSLSL---KTPS-ECLLTPLPPSALPSADDNLKTPAECLLYPLPPSAdDNLKTPPECLLTPLPPS-- 319
Cdd:pfam03154 220 QTQSTAAPHTLIQQTPTLhpqRLPSpHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP-HSLQTGPSHMQHPVPPQpf 298

                          90       100
                  ....*....|....*....|....*..
gi 148596994  320 APPSVDDNLKTPPECVCSLPFHPQRMI 346
Cdd:pfam03154 299 PLTPQSSQSQVPPGPSPAAPGQSQQRI 325
 
Name Accession Description Interval E-value
NPIP pfam06409
Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate ...
 1-267 9.76e-154

Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans.


Pssm-ID: 461900 [Multi-domain]  Cd Length: 267  Bit Score: 432.63  E-value: 9.76e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148596994    1 MFCCLGYEWLSGGCKTWHSAWVINTLADHRHRGTDFGGSPWLLIITVFLRSYKFAISLCTSYLCVSFLKTIFPSQNGHDG 80
Cdd:pfam06409   1 MFCCLADERHRGGCFGGHPALLIITLADHRHKFADFGCSPWLCIIFLFLIFPKFAGHDCSSDLCQRALKSIFPRQEGHDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148596994   81 STDVQQRARRSNRRRQEGIKIVLEDIFTLWRQVETKVRAKIRKMKVTTKVNRHDKINGKRKTAKEHLRKLSMKEREHGEK 160
Cdd:pfam06409  81 SLDDIFRARRQNERKQEAIICKLEDIFKLNRHDEIKGKAKIAKEHLRKKSMKEDEHGEKEKQAKEAEEKGKLDEKEHGEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148596994  161 ERQVSEAEENGKLDMKEIHTYMEMFQRAQALRRRAEDYYRCKITPSARKPLCNRVRMAAVEHRHSSGLPYWPYLTAETLK 240
Cdd:pfam06409 161 EEMFQEAEALGKLAEDEIHCKIEMFARAPACNRRAEAAAECKHSPGAPKPLCLRAEMAAAEHGHQPGLPTQPHLIADNLK 240

                         250       260
                  ....*....|....*....|....*..
gi 148596994  241 NRMGHQPPPPTQQHSIIDNSLSLKTPS 267
Cdd:pfam06409 241 NLKGHPECLLTPLHPIADNSADDKLKP 267
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 246-346 3.77e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.37  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148596994  246 QPPPPTQQHSIIDNSLSL---KTPS-ECLLTPLPPSALPSADDNLKTPAECLLYPLPPSAdDNLKTPPECLLTPLPPS-- 319
Cdd:pfam03154 220 QTQSTAAPHTLIQQTPTLhpqRLPSpHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP-HSLQTGPSHMQHPVPPQpf 298

                          90       100
                  ....*....|....*....|....*..
gi 148596994  320 APPSVDDNLKTPPECVCSLPFHPQRMI 346
Cdd:pfam03154 299 PLTPQSSQSQVPPGPSPAAPGQSQQRI 325
 
Name Accession Description Interval E-value
NPIP pfam06409
Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate ...
 1-267 9.76e-154

Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans.


Pssm-ID: 461900 [Multi-domain]  Cd Length: 267  Bit Score: 432.63  E-value: 9.76e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148596994    1 MFCCLGYEWLSGGCKTWHSAWVINTLADHRHRGTDFGGSPWLLIITVFLRSYKFAISLCTSYLCVSFLKTIFPSQNGHDG 80
Cdd:pfam06409   1 MFCCLADERHRGGCFGGHPALLIITLADHRHKFADFGCSPWLCIIFLFLIFPKFAGHDCSSDLCQRALKSIFPRQEGHDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148596994   81 STDVQQRARRSNRRRQEGIKIVLEDIFTLWRQVETKVRAKIRKMKVTTKVNRHDKINGKRKTAKEHLRKLSMKEREHGEK 160
Cdd:pfam06409  81 SLDDIFRARRQNERKQEAIICKLEDIFKLNRHDEIKGKAKIAKEHLRKKSMKEDEHGEKEKQAKEAEEKGKLDEKEHGEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148596994  161 ERQVSEAEENGKLDMKEIHTYMEMFQRAQALRRRAEDYYRCKITPSARKPLCNRVRMAAVEHRHSSGLPYWPYLTAETLK 240
Cdd:pfam06409 161 EEMFQEAEALGKLAEDEIHCKIEMFARAPACNRRAEAAAECKHSPGAPKPLCLRAEMAAAEHGHQPGLPTQPHLIADNLK 240

                         250       260
                  ....*....|....*....|....*..
gi 148596994  241 NRMGHQPPPPTQQHSIIDNSLSLKTPS 267
Cdd:pfam06409 241 NLKGHPECLLTPLHPIADNSADDKLKP 267
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 246-346 3.77e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.37  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148596994  246 QPPPPTQQHSIIDNSLSL---KTPS-ECLLTPLPPSALPSADDNLKTPAECLLYPLPPSAdDNLKTPPECLLTPLPPS-- 319
Cdd:pfam03154 220 QTQSTAAPHTLIQQTPTLhpqRLPSpHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP-HSLQTGPSHMQHPVPPQpf 298

                          90       100
                  ....*....|....*....|....*..
gi 148596994  320 APPSVDDNLKTPPECVCSLPFHPQRMI 346
Cdd:pfam03154 299 PLTPQSSQSQVPPGPSPAAPGQSQQRI 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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