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Conserved domains on  [gi|6857816|ref|NP_006865|]
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ETS-related transcription factor Elf-2 isoform 2 [Homo sapiens]

Protein Classification

Elf-1_N and Ets domain-containing protein( domain architecture ID 10322456)

Elf-1_N and Ets domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ets pfam00178
Ets-domain;
149-229 1.95e-44

Ets-domain;


:

Pssm-ID: 459700  Cd Length: 80  Bit Score: 151.49  E-value: 1.95e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857816    149 YLWEFLLDLLQDKnTCPRYIKWTQREKGIFKLVDSKAVSKLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQ 228
Cdd:pfam00178   1 QLWQFLLDLLTDP-EYSDIIKWTDKEEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYR 79


                  .
gi 6857816    229 F 229
Cdd:pfam00178  80 F 80
Elf-1_N super family cl13709
Transcription factor protein N terminal; This domain family is found in eukaryotes, and is ...
 14-48 2.19e-07

Transcription factor protein N terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00178. There is a conserved PAVIVE sequence motif. Elf-1 is an immune cell specific transcription factor. It is found in T cells, B cells, megakaryocytes,and mast cells and is involved in the control of transcription for various immune proteins. These include IL-2, GM-CSF, IL-5, IL-2 receptor alpha chain, and CD4 in T cells, IgH, blk, and lyn in B cells, TdT in T and B cells, IL-3 in megakaryocytes, and SCL and Fc-epsilon-RI alpha chain in mast cells.


The actual alignment was detected with superfamily member pfam12310:

Pssm-ID: 463529  Cd Length: 109  Bit Score: 49.38  E-value: 2.19e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 6857816     14 DLLIRAVEASVHSSNaHCTDkTIEAAEALLHMESP 48
Cdd:pfam12310  77 EDVTLTVEASVHGTV-ECMD-TIEAAEALLNMDSP 109
 
Name Accession Description Interval E-value
Ets pfam00178
Ets-domain;
149-229 1.95e-44

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 151.49  E-value: 1.95e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857816    149 YLWEFLLDLLQDKnTCPRYIKWTQREKGIFKLVDSKAVSKLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQ 228
Cdd:pfam00178   1 QLWQFLLDLLTDP-EYSDIIKWTDKEEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYR 79


                  .
gi 6857816    229 F 229
Cdd:pfam00178  80 F 80
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 147-229 2.25e-44

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 151.65  E-value: 2.25e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857816     147 TTYLWEFLLDLLQDKNTcPRYIKWTQREKGIFKLVDSKAVSKLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLV 226
Cdd:smart00413   1 GIQLWQFLLDLLLDPEN-SDIIKWTDRDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLV 79


                   ...
gi 6857816     227 YQF 229
Cdd:smart00413  80 YKF 82
Elf-1_N pfam12310
Transcription factor protein N terminal; This domain family is found in eukaryotes, and is ...
 14-48 2.19e-07

Transcription factor protein N terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00178. There is a conserved PAVIVE sequence motif. Elf-1 is an immune cell specific transcription factor. It is found in T cells, B cells, megakaryocytes,and mast cells and is involved in the control of transcription for various immune proteins. These include IL-2, GM-CSF, IL-5, IL-2 receptor alpha chain, and CD4 in T cells, IgH, blk, and lyn in B cells, TdT in T and B cells, IL-3 in megakaryocytes, and SCL and Fc-epsilon-RI alpha chain in mast cells.


Pssm-ID: 463529  Cd Length: 109  Bit Score: 49.38  E-value: 2.19e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 6857816     14 DLLIRAVEASVHSSNaHCTDkTIEAAEALLHMESP 48
Cdd:pfam12310  77 EDVTLTVEASVHGTV-ECMD-TIEAAEALLNMDSP 109
 
Name Accession Description Interval E-value
Ets pfam00178
Ets-domain;
149-229 1.95e-44

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 151.49  E-value: 1.95e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857816    149 YLWEFLLDLLQDKnTCPRYIKWTQREKGIFKLVDSKAVSKLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQ 228
Cdd:pfam00178   1 QLWQFLLDLLTDP-EYSDIIKWTDKEEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYR 79


                  .
gi 6857816    229 F 229
Cdd:pfam00178  80 F 80
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 147-229 2.25e-44

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 151.65  E-value: 2.25e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857816     147 TTYLWEFLLDLLQDKNTcPRYIKWTQREKGIFKLVDSKAVSKLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLV 226
Cdd:smart00413   1 GIQLWQFLLDLLLDPEN-SDIIKWTDRDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLV 79


                   ...
gi 6857816     227 YQF 229
Cdd:smart00413  80 YKF 82
Elf-1_N pfam12310
Transcription factor protein N terminal; This domain family is found in eukaryotes, and is ...
 14-48 2.19e-07

Transcription factor protein N terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00178. There is a conserved PAVIVE sequence motif. Elf-1 is an immune cell specific transcription factor. It is found in T cells, B cells, megakaryocytes,and mast cells and is involved in the control of transcription for various immune proteins. These include IL-2, GM-CSF, IL-5, IL-2 receptor alpha chain, and CD4 in T cells, IgH, blk, and lyn in B cells, TdT in T and B cells, IL-3 in megakaryocytes, and SCL and Fc-epsilon-RI alpha chain in mast cells.


Pssm-ID: 463529  Cd Length: 109  Bit Score: 49.38  E-value: 2.19e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 6857816     14 DLLIRAVEASVHSSNaHCTDkTIEAAEALLHMESP 48
Cdd:pfam12310  77 EDVTLTVEASVHGTV-ECMD-TIEAAEALLNMDSP 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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