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Conserved domains on  [gi|117320518|ref|NP_006675|]
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complement factor H-related protein 4 isoform 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 92-330 3.16e-17

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 80.08  E-value: 3.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518  92 DIEIENGFISESSSIYILNKEIQYKCKPGYATadgNSSGSI--TCLQNGWSAQPICIKF-CDMPV-FENSRAKSNGMRFK 167
Cdd:PHA02927  29 NMKFKNSVETDANANYNIGDTIEYLCLPGYRK---QKMGPIyaKCTGTGWTLFNQCIKRrCPSPRdIDNGQLDIGGVDFG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518 168 lhDTLDYECYDGYEI-----SYGN--TTGSIVCGEDGwshfPTCynSSEKCGPPPPISNGDTTSFLlKVYVPQSRVEYQC 240
Cdd:PHA02927 106 --SSITYSCNSGYQLigeskSYCElgSTGSMVWNPEA----PIC--ESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSC 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518 241 QSYYELQGSNYVTCSNGEWSEPP-----RCIHPCIiteenmnkNNIQLkgKSDIKYYAKTGDTIEFMCKLGYNANTSVLS 315
Cdd:PHA02927 177 NSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTI--------SNGYL--SSGFKRSYSYNDNVDFKCKYGYKLSGSSSS 246

                        250
                 ....*....|....*
gi 117320518 316 FQAVCREGIVEYPRC 330
Cdd:PHA02927 247 TCSPGNTWQPELPKC 261
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 92-330 3.16e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 80.08  E-value: 3.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518  92 DIEIENGFISESSSIYILNKEIQYKCKPGYATadgNSSGSI--TCLQNGWSAQPICIKF-CDMPV-FENSRAKSNGMRFK 167
Cdd:PHA02927  29 NMKFKNSVETDANANYNIGDTIEYLCLPGYRK---QKMGPIyaKCTGTGWTLFNQCIKRrCPSPRdIDNGQLDIGGVDFG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518 168 lhDTLDYECYDGYEI-----SYGN--TTGSIVCGEDGwshfPTCynSSEKCGPPPPISNGDTTSFLlKVYVPQSRVEYQC 240
Cdd:PHA02927 106 --SSITYSCNSGYQLigeskSYCElgSTGSMVWNPEA----PIC--ESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSC 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518 241 QSYYELQGSNYVTCSNGEWSEPP-----RCIHPCIiteenmnkNNIQLkgKSDIKYYAKTGDTIEFMCKLGYNANTSVLS 315
Cdd:PHA02927 177 NSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTI--------SNGYL--SSGFKRSYSYNDNVDFKCKYGYKLSGSSSS 246

                        250
                 ....*....|....*
gi 117320518 316 FQAVCREGIVEYPRC 330
Cdd:PHA02927 247 TCSPGNTWQPELPKC 261
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 211-266 1.64e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.93  E-value: 1.64e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 117320518 211 CGPPPPISNGDTTSFLlKVYVPQSRVEYQCQSYYELQGSNYVTC-SNGEWS-EPPRCI 266
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCtENGGWSpPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
211-265 9.22e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.26  E-value: 9.22e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 117320518  211 CGPPPPISNGDTTSfLLKVYVPQSRVEYQCQSYYELQGSNYVTCS-NGEWS-EPPRC 265
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 211-265 2.02e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.14  E-value: 2.02e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 117320518   211 CGPPPPISNGDTTSFLlKVYVPQSRVEYQCQSYYELQGSNYVTC-SNGEWS-EPPRC 265
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITClENGTWSpPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 92-330 3.16e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 80.08  E-value: 3.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518  92 DIEIENGFISESSSIYILNKEIQYKCKPGYATadgNSSGSI--TCLQNGWSAQPICIKF-CDMPV-FENSRAKSNGMRFK 167
Cdd:PHA02927  29 NMKFKNSVETDANANYNIGDTIEYLCLPGYRK---QKMGPIyaKCTGTGWTLFNQCIKRrCPSPRdIDNGQLDIGGVDFG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518 168 lhDTLDYECYDGYEI-----SYGN--TTGSIVCGEDGwshfPTCynSSEKCGPPPPISNGDTTSFLlKVYVPQSRVEYQC 240
Cdd:PHA02927 106 --SSITYSCNSGYQLigeskSYCElgSTGSMVWNPEA----PIC--ESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSC 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518 241 QSYYELQGSNYVTCSNGEWSEPP-----RCIHPCIiteenmnkNNIQLkgKSDIKYYAKTGDTIEFMCKLGYNANTSVLS 315
Cdd:PHA02927 177 NSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTI--------SNGYL--SSGFKRSYSYNDNVDFKCKYGYKLSGSSSS 246

                        250
                 ....*....|....*
gi 117320518 316 FQAVCREGIVEYPRC 330
Cdd:PHA02927 247 TCSPGNTWQPELPKC 261
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 70-266 2.18e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 68.91  E-value: 2.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518  70 YIHCTQDGWSPTVPCLRTCSKSDIEIENGFISESSSIYilNKEIQYKCKPGY-------ATADGNSSGSITclqngWSAQ 142
Cdd:PHA02927  67 YAKCTGTGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYqligeskSYCELGSTGSMV-----WNPE 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518 143 -PIC--IKFCDMPVFENSRAKSNGMRFKLHDTLDYECYDGYEIsYGNTtgSIVCGEDGWSHFPTCynSSEKCgPPPPISN 219
Cdd:PHA02927 140 aPICesVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSL-IGNS--GVLCSGGEWSDPPTC--QIVKC-PHPTISN 213

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 117320518 220 GDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSEP--PRCI 266
Cdd:PHA02927 214 GYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPelPKCV 262
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 211-266 1.64e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.93  E-value: 1.64e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 117320518 211 CGPPPPISNGDTTSFLlKVYVPQSRVEYQCQSYYELQGSNYVTC-SNGEWS-EPPRCI 266
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCtENGGWSpPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
211-265 9.22e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.26  E-value: 9.22e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 117320518  211 CGPPPPISNGDTTSfLLKVYVPQSRVEYQCQSYYELQGSNYVTCS-NGEWS-EPPRC 265
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 211-265 2.02e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.14  E-value: 2.02e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 117320518   211 CGPPPPISNGDTTSFLlKVYVPQSRVEYQCQSYYELQGSNYVTC-SNGEWS-EPPRC 265
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITClENGTWSpPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 88-266 3.52e-06

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 47.74  E-value: 3.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518  88 CSKSDiEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNG-WSAQ-PIC-IKFC-DMPVFENSRAKSNG 163
Cdd:PHA02639  22 CDKPD-DISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAiWSNKaPFCmLKECnDPPSIINGKIYNKR 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518 164 MRFKLHDTLDYECYDGYEISY---GNTtgSIVCGEDgwshfptcynSSEKCGPP---------PPISNGDTTSFLL-KVY 230
Cdd:PHA02639 101 EMYKVGDEIYYVCNEHKGVQYslvGNE--KITCIQD----------KSWKPDPPickmincrfPALQNGYINGIPSnKKF 168

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 117320518 231 VPQSRVEYQCQSYYELQGSNYVTCS-NGEW-SEPPRCI 266
Cdd:PHA02639 169 YYKTRVGFSCKSGFDLVGEKYSTCNiNATWfPSIPTCV 206
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 94-146 8.43e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.75  E-value: 8.43e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 117320518  94 EIENGFISESSSIYILNKEIQYKCKPGYATadgNSSGSITCLQNG-WS-AQPICI 146
Cdd:cd00033    6 VPENGTVTGSKGSYSYGSTVTYSCNEGYTL---VGSSTITCTENGgWSpPPPTCE 57
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 50-266 2.11e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 42.38  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518  50 QSYSYYCDQNFVTPSGSywdyIHCTQDGWSPTVPCLRTCSKSDI--EIENGFISESSSIYIL--NKEIQY-KCKpgyaTA 124
Cdd:PHA02954  42 QKVTFTCDSGYYSLDPN----AVCETDKWKYENPCKKMCTVSDYvsELYDKPLYEVNSTITLicKDETKYfRCE----EK 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518 125 DGNSSGSITCLQNGWSAQPICIkfcdmpvfENSRAKSNGMRFKLHDTLDYECYDGYEISygnTTGSIVCGEDGWSHFPTC 204
Cdd:PHA02954 114 NGNTSWNDTVTCPNAECQPLQL--------EHGSCQPVKEKYSFGEHITINCDVGYEVI---GASYISCTANSWNVIPSC 182

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117320518 205 ynsSEKCGPPPpISNGDTTSFLLKVyvpQSRVEYQCQSYYELQGSNYVTCSNGEWSEP-PRCI 266
Cdd:PHA02954 183 ---QQKCDIPS-LSNGLISGSTFSI---GGVIHLSCKSGFTLTGSPSSTCIDGKWNPVlPICV 238
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 94-145 2.21e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.66  E-value: 2.21e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 117320518    94 EIENGFISESSSIYILNKEIQYKCKPGYATadgNSSGSITCLQNG-WS-AQPIC 145
Cdd:smart00032   6 DIENGTVTSSSGTYSYGDTVTYSCDPGYTL---IGSSTITCLENGtWSpPPPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 78-213 2.97e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 42.00  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518  78 WSPTVPCLRTCSKSdIEIENGFISESSSIYILNKEIQYKCKPGYATAdgnSSGSITCLQNGWSAQPICIKFCDMPVFENS 157
Cdd:PHA02954 119 WNDTVTCPNAECQP-LQLEHGSCQPVKEKYSFGEHITINCDVGYEVI---GASYISCTANSWNVIPSCQQKCDIPSLSNG 194

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 117320518 158 RAksNGMRFKLHDTLDYECYDGYEISygnTTGSIVCGEDGWSH-FPTCYNSSEKCGP 213
Cdd:PHA02954 195 LI--SGSTFSIGGVIHLSCKSGFTLT---GSPSSTCIDGKWNPvLPICVRSNEEFDP 246
PHA02831 PHA02831
EEV host range protein; Provisional
 224-331 2.90e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 38.82  E-value: 2.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320518 224 SFLLKVYVPQSRVEYQCQSYYElqgSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNiQLKGKSDiKYyaKTGDTIEFMC 303
Cdd:PHA02831  34 SYENKVYEENENLEYKCNNNFD---KVFVTCNNGSWSTKNMCIGKRNCKDPVTILNG-YIKNKKD-QY--SFGDSVTYAC 106

                         90       100       110
                 ....*....|....*....|....*....|.
gi 117320518 304 KLGYNANTSVLSFQAV-CREG--IVEYPRCE 331
Cdd:PHA02831 107 KVNKLEKYSIVGNETVkCINKqwVPKYPVCK 137
Sushi pfam00084
Sushi repeat (SCR repeat);
95-145 7.52e-03

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 34.40  E-value: 7.52e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 117320518   95 IENGFISESSSIYILNKEIQYKCKPGYATADGNssgSITCLQNG-WS-AQPIC 145
Cdd:pfam00084   7 IPNGKVSATKNEYNYGASVSYECDPGYRLVGSP---TITCQEDGtWSpPFPEC 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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