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Conserved domains on  [gi|150417986|ref|NP_006411|]
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brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform 1 [Homo sapiens]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1711 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1060.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986   11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986   73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEnqvlqeARELEKPIQskpqsPVIQAAAVSPkfvr 232
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRME------ADSSTVPIQ-----PIVVAELMEP---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  233 lkhsqaqskpttPEKTDlTNGEHARSDSGKVSTENGD-----APRERGSSL-SGTDDGAQEVVKDIlEDVVTSAIKEAAE 306
Cdd:PLN03076  235 ------------AEKSD-SDTSMTQFVQGFITKIMQDidgvlNPATAGKSSgSGAHDGAFETTATV-ETTNPADLLDSTD 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  307 KHGLtepERVLGELECQECAIPPGVDENSQTNGIADDrqslssadnlESDAQghqvaarFSHVLQKDAFLVFRSLCKLSM 386
Cdd:PLN03076  301 KDML---DAKYWEISMYKSALEGRKGELADGEVEKDD----------DLEVQ-------IGNKLRRDAFLVFRALCKLSM 360

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  387 K-PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSN 465
Cdd:PLN03076  361 KtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSR 438

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  466 FKMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQG- 543
Cdd:PLN03076  439 FRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGv 518

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  544 RSGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQTslgqERLTDQEIGDGKG-LDMARRCSVTSMEST 621
Cdd:PLN03076  519 PPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsLPVANGNGDENGEGS 594

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  622 VSSGTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSA 701
Cdd:PLN03076  595 DSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGERE 674

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  702 RFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASADTAYVLAYSIIMLTT 781
Cdd:PLN03076  675 DLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNT 752

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  782 DLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKE-----TKE--------------LTIATKST 842
Cdd:PLN03076  753 DAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEddlvpQQKqsansnrilgldsiLNIVIRKR 832

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  843 KQNVASEKQRRLLYNLEMEQMAKTAKAlmEAVshakapFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCL 922
Cdd:PLN03076  833 GEDSYMETSDDLIKHMQEQFKEKARKS--ESV------YYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCL 904

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  923 EGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELA 1002
Cdd:PLN03076  905 EGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHL 981

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1003 QLIGTG--------------------VKTRYLSGSGREREGSLKGHTLAGEE--FMGLGLGNLVSGGVDKRQMAS----- 1055
Cdd:PLN03076  982 HLLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTSEQMNNlvsnl 1061

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1056 -FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRI 1134
Cdd:PLN03076 1062 nMLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSI 1134

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1135 WHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQ 1214
Cdd:PLN03076 1135 WHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSR 1214

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1215 AANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLI 1294
Cdd:PLN03076 1215 VNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDISLNAIAFL 1294

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1295 RFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVRTRGLTVMFEI 1358
Cdd:PLN03076 1295 RFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDT 1374

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1359 MKSYGHTFEKHWWQDLFRIV-FRIFDNMKLPEQLSEKSE-----------------WMTTTCNHALYAICDVFTQFYEAL 1420
Cdd:PLN03076 1375 LRNHGHLFSLPLWERVFESVlFPIFDYVRHAIDPSGGDEpegqgvdgdqgeldqdaWLYETCTLALQLVVDLFVKFYPTV 1454

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1421 NEvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSE 1500
Cdd:PLN03076 1455 NP-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVSGEYMPAENIQ 1533

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1501 khlDVDLDRQSLSSIDKNPSERGQSqlsnptddswkgrpyanQKLFASLL-IKC--VVQLELIQTIdnivfypatskked 1577
Cdd:PLN03076 1534 ---DSENAEAASSSTADNDAEAERS-----------------RRLYAAISdAKCraAVQLLLIQAV-------------- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1578 aehmvaaqqdtldadihieTEDQGMYK-YMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSK-PNLLKQE 1655
Cdd:PLN03076 1580 -------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLE 1640

                        1770      1780      1790      1800      1810
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 150417986 1656 TSSLACCLRILFRMYVDENRRDSWEEIQQRLLTVCSEALAYFItvnsESHREAWTS 1711
Cdd:PLN03076 1641 NESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1711 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1060.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986   11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986   73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEnqvlqeARELEKPIQskpqsPVIQAAAVSPkfvr 232
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRME------ADSSTVPIQ-----PIVVAELMEP---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  233 lkhsqaqskpttPEKTDlTNGEHARSDSGKVSTENGD-----APRERGSSL-SGTDDGAQEVVKDIlEDVVTSAIKEAAE 306
Cdd:PLN03076  235 ------------AEKSD-SDTSMTQFVQGFITKIMQDidgvlNPATAGKSSgSGAHDGAFETTATV-ETTNPADLLDSTD 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  307 KHGLtepERVLGELECQECAIPPGVDENSQTNGIADDrqslssadnlESDAQghqvaarFSHVLQKDAFLVFRSLCKLSM 386
Cdd:PLN03076  301 KDML---DAKYWEISMYKSALEGRKGELADGEVEKDD----------DLEVQ-------IGNKLRRDAFLVFRALCKLSM 360

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  387 K-PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSN 465
Cdd:PLN03076  361 KtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSR 438

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  466 FKMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQG- 543
Cdd:PLN03076  439 FRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGv 518

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  544 RSGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQTslgqERLTDQEIGDGKG-LDMARRCSVTSMEST 621
Cdd:PLN03076  519 PPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsLPVANGNGDENGEGS 594

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  622 VSSGTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSA 701
Cdd:PLN03076  595 DSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGERE 674

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  702 RFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASADTAYVLAYSIIMLTT 781
Cdd:PLN03076  675 DLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNT 752

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  782 DLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKE-----TKE--------------LTIATKST 842
Cdd:PLN03076  753 DAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEddlvpQQKqsansnrilgldsiLNIVIRKR 832

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  843 KQNVASEKQRRLLYNLEMEQMAKTAKAlmEAVshakapFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCL 922
Cdd:PLN03076  833 GEDSYMETSDDLIKHMQEQFKEKARKS--ESV------YYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCL 904

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  923 EGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELA 1002
Cdd:PLN03076  905 EGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHL 981

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1003 QLIGTG--------------------VKTRYLSGSGREREGSLKGHTLAGEE--FMGLGLGNLVSGGVDKRQMAS----- 1055
Cdd:PLN03076  982 HLLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTSEQMNNlvsnl 1061

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1056 -FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRI 1134
Cdd:PLN03076 1062 nMLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSI 1134

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1135 WHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQ 1214
Cdd:PLN03076 1135 WHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSR 1214

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1215 AANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLI 1294
Cdd:PLN03076 1215 VNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDISLNAIAFL 1294

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1295 RFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVRTRGLTVMFEI 1358
Cdd:PLN03076 1295 RFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDT 1374

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1359 MKSYGHTFEKHWWQDLFRIV-FRIFDNMKLPEQLSEKSE-----------------WMTTTCNHALYAICDVFTQFYEAL 1420
Cdd:PLN03076 1375 LRNHGHLFSLPLWERVFESVlFPIFDYVRHAIDPSGGDEpegqgvdgdqgeldqdaWLYETCTLALQLVVDLFVKFYPTV 1454

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1421 NEvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSE 1500
Cdd:PLN03076 1455 NP-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVSGEYMPAENIQ 1533

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1501 khlDVDLDRQSLSSIDKNPSERGQSqlsnptddswkgrpyanQKLFASLL-IKC--VVQLELIQTIdnivfypatskked 1577
Cdd:PLN03076 1534 ---DSENAEAASSSTADNDAEAERS-----------------RRLYAAISdAKCraAVQLLLIQAV-------------- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1578 aehmvaaqqdtldadihieTEDQGMYK-YMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSK-PNLLKQE 1655
Cdd:PLN03076 1580 -------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLE 1640

                        1770      1780      1790      1800      1810
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 150417986 1656 TSSLACCLRILFRMYVDENRRDSWEEIQQRLLTVCSEALAYFItvnsESHREAWTS 1711
Cdd:PLN03076 1641 NESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 643-827 1.68e-95

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 305.92  E-value: 1.68e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986   643 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEF 722
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986   723 VSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 802
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 150417986   803 GINDSKDLPEEYLSSIYEEIEGKKI 827
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 643-827 1.12e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 277.95  E-value: 1.12e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  643 QKEIIEHGIELFNKKPKRGIQFLQEQGML-GTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKE 721
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  722 FVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 801
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                         170       180
                  ....*....|....*....|....*.
gi 150417986  802 RGINDSKDLPEEYLSSIYEEIEGKKI 827
Cdd:cd00171   160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 641-827 1.20e-79

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 260.69  E-value: 1.20e-79
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986    641 KQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGT-SVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCE 719
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986    720 KEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIK 799
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 150417986    800 MNRGINDSKDLPEEYLSSIYEEIEGKKI 827
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1711 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1060.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986   11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986   73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEnqvlqeARELEKPIQskpqsPVIQAAAVSPkfvr 232
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRME------ADSSTVPIQ-----PIVVAELMEP---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  233 lkhsqaqskpttPEKTDlTNGEHARSDSGKVSTENGD-----APRERGSSL-SGTDDGAQEVVKDIlEDVVTSAIKEAAE 306
Cdd:PLN03076  235 ------------AEKSD-SDTSMTQFVQGFITKIMQDidgvlNPATAGKSSgSGAHDGAFETTATV-ETTNPADLLDSTD 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  307 KHGLtepERVLGELECQECAIPPGVDENSQTNGIADDrqslssadnlESDAQghqvaarFSHVLQKDAFLVFRSLCKLSM 386
Cdd:PLN03076  301 KDML---DAKYWEISMYKSALEGRKGELADGEVEKDD----------DLEVQ-------IGNKLRRDAFLVFRALCKLSM 360

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  387 K-PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSN 465
Cdd:PLN03076  361 KtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSR 438

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  466 FKMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQG- 543
Cdd:PLN03076  439 FRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGv 518

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  544 RSGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQTslgqERLTDQEIGDGKG-LDMARRCSVTSMEST 621
Cdd:PLN03076  519 PPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsLPVANGNGDENGEGS 594

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  622 VSSGTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSA 701
Cdd:PLN03076  595 DSHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGERE 674

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  702 RFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASADTAYVLAYSIIMLTT 781
Cdd:PLN03076  675 DLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNT 752

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  782 DLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKE-----TKE--------------LTIATKST 842
Cdd:PLN03076  753 DAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEddlvpQQKqsansnrilgldsiLNIVIRKR 832

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  843 KQNVASEKQRRLLYNLEMEQMAKTAKAlmEAVshakapFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCL 922
Cdd:PLN03076  833 GEDSYMETSDDLIKHMQEQFKEKARKS--ESV------YYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCL 904

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  923 EGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELA 1002
Cdd:PLN03076  905 EGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHL 981

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1003 QLIGTG--------------------VKTRYLSGSGREREGSLKGHTLAGEE--FMGLGLGNLVSGGVDKRQMAS----- 1055
Cdd:PLN03076  982 HLLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTSEQMNNlvsnl 1061

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1056 -FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRI 1134
Cdd:PLN03076 1062 nMLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSI 1134

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1135 WHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQ 1214
Cdd:PLN03076 1135 WHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSR 1214

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1215 AANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLI 1294
Cdd:PLN03076 1215 VNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDISLNAIAFL 1294

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1295 RFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVRTRGLTVMFEI 1358
Cdd:PLN03076 1295 RFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDT 1374

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1359 MKSYGHTFEKHWWQDLFRIV-FRIFDNMKLPEQLSEKSE-----------------WMTTTCNHALYAICDVFTQFYEAL 1420
Cdd:PLN03076 1375 LRNHGHLFSLPLWERVFESVlFPIFDYVRHAIDPSGGDEpegqgvdgdqgeldqdaWLYETCTLALQLVVDLFVKFYPTV 1454

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1421 NEvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSE 1500
Cdd:PLN03076 1455 NP-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVSGEYMPAENIQ 1533

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1501 khlDVDLDRQSLSSIDKNPSERGQSqlsnptddswkgrpyanQKLFASLL-IKC--VVQLELIQTIdnivfypatskked 1577
Cdd:PLN03076 1534 ---DSENAEAASSSTADNDAEAERS-----------------RRLYAAISdAKCraAVQLLLIQAV-------------- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986 1578 aehmvaaqqdtldadihieTEDQGMYK-YMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSK-PNLLKQE 1655
Cdd:PLN03076 1580 -------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLE 1640

                        1770      1780      1790      1800      1810
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 150417986 1656 TSSLACCLRILFRMYVDENRRDSWEEIQQRLLTVCSEALAYFItvnsESHREAWTS 1711
Cdd:PLN03076 1641 NESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 643-827 1.68e-95

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 305.92  E-value: 1.68e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986   643 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEF 722
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986   723 VSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 802
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 150417986   803 GINDSKDLPEEYLSSIYEEIEGKKI 827
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 643-827 1.12e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 277.95  E-value: 1.12e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  643 QKEIIEHGIELFNKKPKRGIQFLQEQGML-GTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKE 721
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  722 FVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 801
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                         170       180
                  ....*....|....*....|....*.
gi 150417986  802 RGINDSKDLPEEYLSSIYEEIEGKKI 827
Cdd:cd00171   160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 641-827 1.20e-79

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 260.69  E-value: 1.20e-79
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986    641 KQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGT-SVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCE 719
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986    720 KEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIK 799
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 150417986    800 MNRGINDSKDLPEEYLSSIYEEIEGKKI 827
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1554-1760 5.45e-58

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 198.23  E-value: 5.45e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  1554 VVQLELIQTIDNIVfypatskkedaehmvaaqqdtldadihietedQGMYKYMSSQHLFKLLDCLQESHSFSKAFNSNYE 1633
Cdd:pfam20252    1 VVQLLLIQTVNEIL--------------------------------DEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLE 48

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  1634 QRTVLWRAGFkGKSKPNLLKQETSSLACCLRILFRMYVDENRR-DSWEEIQQRLLTVCSEALAYFITVN-SESHRE--AW 1709
Cdd:pfam20252   49 LRTALWRAGF-MKQLPNLLKQETSSLSTYLRILFRLYADDEPRtSQREEVEERLIPLCEDILEYYLSLDeEEKQRElaAW 127

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 150417986  1710 TSLLLLLLTKTLKINDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFL 1760
Cdd:pfam20252  128 TPVVVLILQGLLALPDDDFRRHLPEFYPLLCDLILCELSPEVRLALREFFS 178
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 370-525 6.73e-53

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 182.69  E-value: 6.73e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986   370 LQKDAFLVFRSLCKLS-MKPLGEgpPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSV 448
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSnGKPLSK--SDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSS 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 150417986   449 PDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILEtSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLN 525
Cdd:pfam12783   79 FPVFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLE-SDSSLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 28-197 3.31e-41

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 149.71  E-value: 3.31e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986    28 QHSQLRRACQVALDEIKAEIEKQ-------------RL---GTAAPPKANFIEA-DKYFLPFELACQSKSPRVVSTSLDC 90
Cdd:pfam16213    1 QGSKLLEALQSDLRTLSSEAKRKyppvkeasekgilRLrtvHSSSPLMQNLLSAsEDILKPFVLACETKNPKLVQIALGC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986    91 LQKLIAYGHITGNApdsgapgkrlIDRIVETICSCFQGPQTdegVQLQIIKALLTAVTSPHIeIHEGTILQTVRTCYNIY 170
Cdd:pfam16213   81 LQKLISHDAISQSA----------APYILDTLWMLMELGSE---IELKVLQTVLLLITTNSV-IHGDTLAKALVLCFRLH 146

                          170       180
                   ....*....|....*....|....*..
gi 150417986   171 LaSKNLINQTTAKATLTQMLNVIFTRM 197
Cdd:pfam16213  147 F-SKDPTVQNTASATLRQLVSVVFERV 172
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1167-1248 4.10e-36

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 131.84  E-value: 4.10e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150417986  1167 KFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQ 1246
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ..
gi 150417986  1247 TT 1248
Cdd:pfam09324   81 IL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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