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Conserved domains on  [gi|5454104|ref|NP_006345|]
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transcriptional adapter 3 isoform a [Homo sapiens]

Protein Classification

Ada3 domain-containing protein( domain architecture ID 10562882)

Ada3 ((Alteration/deficiency in activation-3)) domain-containing protein may function as a transcriptional adapter; Ada3 is an essential component of the Ada transcriptional coactivator complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ada3 pfam10198
Histone acetyltransferases subunit 3; Ada3 is a family of proteins conserved from yeasts to ...
 309-422 1.05e-29

Histone acetyltransferases subunit 3; Ada3 is a family of proteins conserved from yeasts to humans. It is an essential component of the Ada transcriptional coactivator (alteration/deficiency in activation) complex. Ada3 plays a key role in linking histone acetyltransferase-containing complexes to p53 (tumour suppressor protein) thereby regulating p53 acetylation, stability and transcriptional activation following DNA damage.


:

Pssm-ID: 462993  Cd Length: 123  Bit Score: 111.90  E-value: 1.05e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454104    309 PHTKSLESRIKEELIAQGLLESEDRPAEDS--EDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRM 386
Cdd:pfam10198   1 LDYATLEERLKKELRYIGILDPDDDPDYDNreDDEILAELRRLQAELKAVSARNGARKKRLLELAKEEMARQEYKTILDD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 5454104    387 ADNEVMDAFRKimaarqKKRTPTKKEKDQ-------------AWKTLKE 422
Cdd:pfam10198  81 LDKQVDQAYLK------RKRTLTKKKKKKraaagaaqpgagdALKALME 123
 
Name Accession Description Interval E-value
Ada3 pfam10198
Histone acetyltransferases subunit 3; Ada3 is a family of proteins conserved from yeasts to ...
 309-422 1.05e-29

Histone acetyltransferases subunit 3; Ada3 is a family of proteins conserved from yeasts to humans. It is an essential component of the Ada transcriptional coactivator (alteration/deficiency in activation) complex. Ada3 plays a key role in linking histone acetyltransferase-containing complexes to p53 (tumour suppressor protein) thereby regulating p53 acetylation, stability and transcriptional activation following DNA damage.


Pssm-ID: 462993  Cd Length: 123  Bit Score: 111.90  E-value: 1.05e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454104    309 PHTKSLESRIKEELIAQGLLESEDRPAEDS--EDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRM 386
Cdd:pfam10198   1 LDYATLEERLKKELRYIGILDPDDDPDYDNreDDEILAELRRLQAELKAVSARNGARKKRLLELAKEEMARQEYKTILDD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 5454104    387 ADNEVMDAFRKimaarqKKRTPTKKEKDQ-------------AWKTLKE 422
Cdd:pfam10198  81 LDKQVDQAYLK------RKRTLTKKKKKKraaagaaqpgagdALKALME 123
 
Name Accession Description Interval E-value
Ada3 pfam10198
Histone acetyltransferases subunit 3; Ada3 is a family of proteins conserved from yeasts to ...
 309-422 1.05e-29

Histone acetyltransferases subunit 3; Ada3 is a family of proteins conserved from yeasts to humans. It is an essential component of the Ada transcriptional coactivator (alteration/deficiency in activation) complex. Ada3 plays a key role in linking histone acetyltransferase-containing complexes to p53 (tumour suppressor protein) thereby regulating p53 acetylation, stability and transcriptional activation following DNA damage.


Pssm-ID: 462993  Cd Length: 123  Bit Score: 111.90  E-value: 1.05e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454104    309 PHTKSLESRIKEELIAQGLLESEDRPAEDS--EDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRM 386
Cdd:pfam10198   1 LDYATLEERLKKELRYIGILDPDDDPDYDNreDDEILAELRRLQAELKAVSARNGARKKRLLELAKEEMARQEYKTILDD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 5454104    387 ADNEVMDAFRKimaarqKKRTPTKKEKDQ-------------AWKTLKE 422
Cdd:pfam10198  81 LDKQVDQAYLK------RKRTLTKKKKKKraaagaaqpgagdALKALME 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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