NCBI Conserved Domain Search

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...

220-485

5.57e-78

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440835 [Multi-domain] Cd Length: 326 Bit Score: 253.39 E-value: 5.57e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLDKEFSDIfRRAFasrVFP---PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNA---RepkvVNGPEILNK 293
Cdd:COG1222   80 IGGLDEQIEEI-REAV---ELPlknPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGApfiR----VRGSELVSK 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 294 YVGESEANIRKLFADAEEEQRRlgansglhIIIFDEIDAICKQRGSMaGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMT 373
Cdd:COG1222  152 YIGEGARNVREVFELAREKAPS--------IIFIDEIDAIAARRTDD-GTSGEVQRTVNQLLAELDGFESRGDVLIIAAT 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 374 NRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAAQSTAM 453
Cdd:COG1222  223 NRPDLLDPALLRPGRFDRVIEVPLPDEEAREEILKIHLRDMP----LADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAI 298

                        250       260       270
                 ....*....|....*....|....*....|..
gi 156564401 454 NRHIKastkvevdmekaeslQVTRGDFLASLE 485
Cdd:COG1222  299 REGRD---------------TVTMEDLEKAIE 315

CDC48

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...

159-606

9.95e-65

Pssm-ID: 273521 [Multi-domain] Cd Length: 733 Bit Score: 229.02 E-value: 9.95e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  159 ILKGEPATGKRQKIEVGLVVGNSQVA--FEKAENSSLNLIGKAKTKENRQSIinPDWNFEKmgIGGLDKEFSDIfRRAFA 236
Cdd:TIGR01243 121 ISKGETVIVPVLEGALPFVVVSTQPAgfVYVTEATEVEIREKPVREEIERKV--PKVTYED--IGGLKEAKEKI-REMVE 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  237 SRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREpKVVNGPEILNKYVGESEANIRKLFADAEEeqrrl 316
Cdd:TIGR01243 196 LPMKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYF-ISINGPEIMSKYYGESEERLREIFKEAEE----- 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  317 ganSGLHIIIFDEIDAICKQRGSMAGStgVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIG 396
Cdd:TIGR01243 270 ---NAPSIIFIDEIDAIAPKREEVTGE--VEKRVVAQLLTLMDGLKGRGRVIVIGATNRPDALDPALRRPGRFDREIVIR 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  397 LPDEKGRLQILHIHTARMrghqLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKAST----KVEVDMEKAES 472
Cdd:TIGR01243 345 VPDKRARKEILKVHTRNM----PLAEDVDLDKLAEVTHGFVGADLAALAKEAAMAALRRFIREGKinfeAEEIPAEVLKE 420

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  473 LQVTRGDFLASLEnDIKPAFGTNqedyaSYIMNGIIKWGD-----PVTRVLDDG-ELLVQQTKNSDR---TPLVSVLLEG 543
Cdd:TIGR01243 421 LKVTMKDFMEALK-MVEPSAIRE-----VLVEVPNVRWSDiggleEVKQELREAvEWPLKHPEIFEKmgiRPPKGVLLFG 494

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156564401  544 PPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSEtakcQAMKKIFDDAYKSQLSCVVVDDIE 606
Cdd:TIGR01243 495 PPGTGKTLLAKAVATESGANFIAVRGPEilsKWVGESE----KAIREIFRKARQAAPAIIFFDEID 556

CDC48

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...

220-502

1.98e-58

Pssm-ID: 273521 [Multi-domain] Cd Length: 733 Bit Score: 211.30 E-value: 1.98e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  220 IGGLDkEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREpKVVNGPEILNKYVGESE 299
Cdd:TIGR01243 455 IGGLE-EVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANF-IAVRGPEILSKWVGESE 532

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  300 ANIRKLFADAEEeqrrlganSGLHIIIFDEIDAICKQRGSMAGSTgVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLI 379
Cdd:TIGR01243 533 KAIREIFRKARQ--------AAPAIIFFDEIDAIAPARGARFDTS-VTDRIVNQLLTEMDGIQELSNVVVIAATNRPDIL 603

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  380 DEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKA 459
Cdd:TIGR01243 604 DPALLRPGRFDRLILVPPPDEEARKEIFKIHTRSMP----LAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGS 679

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 156564401  460 STKVEVDMEKAE---SLQVTRGDFLASLENdIKPAFgtNQEDYASY 502
Cdd:TIGR01243 680 PAKEKLEVGEEEflkDLKVEMRHFLEALKK-VKPSV--SKEDMLRY 722

PRK03992

proteasome-activating nucleotidase; Provisional

220-477

6.01e-54

proteasome-activating nucleotidase; Provisional

Pssm-ID: 179699 [Multi-domain] Cd Length: 389 Bit Score: 190.81 E-value: 6.01e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLDKEFSDIfRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVnGPEILNKYVGESE 299
Cdd:PRK03992 133 IGGLEEQIREV-REAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVV-GSELVQKFIGEGA 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 300 ANIRKLFADAEEEqrrlgANSglhiIIF-DEIDAICKQRGSMA--GSTGVHDTVVnQLLSKIDGVEQLNNILVIGMTNRP 376
Cdd:PRK03992 211 RLVRELFELAREK-----APS----IIFiDEIDAIAAKRTDSGtsGDREVQRTLM-QLLAEMDGFDPRGNVKIIAATNRI 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 377 DLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAAQSTA---- 452
Cdd:PRK03992 281 DILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKMN----LADDVDLEELAELTEGASGADLKAICTEAGMFAirdd 356

                        250       260       270
                 ....*....|....*....|....*....|
gi 156564401 453 -----MNRHIKASTKVEVDMEKAESLQVTR 477
Cdd:PRK03992 357 rtevtMEDFLKAIEKVMGKEEKDSMEEPGV 386

AAA

ATPase family associated with various cellular activities (AAA); AAA family proteins often ...

256-397

1.37e-42

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.

Pssm-ID: 459627 [Multi-domain] Cd Length: 130 Bit Score: 150.44 E-value: 1.37e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  256 ILLYGPPGCGKTLLARQIGKMLNArEPKVVNGPEILNKYVGESEANIRKLFADAEEEQrrlgansgLHIIIFDEIDAICK 335
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGA-PFIEISGSELVSKYVGESEKRLRELFEAAKKLA--------PCVIFIDEIDALAG 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156564401  336 QRGSmaGSTGVHDTVVNQLLSKIDGVEQL-NNILVIGMTNRPDLIDEALLrpGRLEVKMEIGL 397
Cdd:pfam00004  72 SRGS--GGDSESRRVVNQLLTELDGFTSSnSKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130

cell_div_CdvC

NF041006

cell division protein CdvC;

254-448

1.56e-31

cell division protein CdvC;

Pssm-ID: 468935 [Multi-domain] Cd Length: 371 Bit Score: 126.77 E-value: 1.56e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 254 KGILLYGPPGCGKTLLARQIGKMLNArEPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSglhIIIFDEIDAI 333
Cdd:NF041006 135 RGILLYGPPGCGKTMLAAAVANEIDS-EFIHVDAASIMSKWLGEAEKNVAKIFKKAREKSKEEGKPA---IIFIDEIDAL 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 334 CkqrGSMAGSTGVHDTVVNQLLSKIDGVEQLNNIL---VIGMTNRPDLIDEALLRpgRLEVKMEIGLPDEKGRLQILHIH 410
Cdd:NF041006 211 L---GVYSSEVGGEVRVRNQFLKEMDGLQDKSENYhvyVIGATNKPWRLDEPFLR--RFQKRIYIPLPDREQRLELLKYY 285

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 156564401 411 TARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAA 448
Cdd:NF041006 286 TSKIK----LENDVDLDELAEMTEGYTASDIRDIVQAA 319

CDC48_N

smart01073

Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel ...

6-83

8.53e-18

Pssm-ID: 215012 [Multi-domain] Cd Length: 82 Bit Score: 78.42 E-value: 8.53e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401     6 MQAARCPTDELSLTNCAVVNEKDFQS-----GQHVIVRtspNHRYTFTLK--THPSVVPGSIAFSLPQRKWAGLSIGQEI 78
Cdd:smart01073   1 LRVAEAPSDEDVGRGIARLSPEDMDElglfpGDYVLIT---GKRRTVAIVwpAYPEDPGGIIRIDGVQRKNAGVSIGDTV 77


                   ....*
gi 156564401    79 EVSLY 83
Cdd:smart01073  78 TVRKA 82

AAA

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...

254-399

3.26e-15

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.

Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 73.56 E-value: 3.26e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401   254 KGILLYGPPGCGKTLLARQIGKMLNAREPKVV----------------NGPEILNKYVGESEANIRKLFADAEEEQRRlg 317
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPGGGVIyidgedileevldqllLIIVGGKKASGSGELRLRLALALARKLKPD-- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401   318 ansglhIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKidgveqlNNILVIGMTNRPDLIDEALLRPgRLEVKMEIGL 397
Cdd:smart00382  81 ------VLILDEITSLLDAEQEALLLLLEELRLLLLLKSE-------KNLTVILTTNDEKDLGPALLRR-RFDRRIVLLL 146


                   ..
gi 156564401   398 PD 399
Cdd:smart00382 147 IL 148

CDC48_N

pfam02359

Cell division protein 48 (CDC48), N-terminal domain; This domain has a double psi-beta barrel ...

5-85

5.57e-14

Cell division protein 48 (CDC48), N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases pfam00004 is a substrate 185-residue recognition domain.

Pssm-ID: 426738 Cd Length: 85 Bit Score: 67.61 E-value: 5.57e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401    5 SMQAARCPtDELSLTNCAVVNEKDFQS--GQHVIVRTSPNHRYT----FTLKTHPSVvPGSIAFSLPQRKWAGLSIGQEI 78
Cdd:pfam02359   1 RLRVAEAP-DRDVGRGIARLNPEDMEElgLFPGDVVEIKGKRKTvaivWSAYPEDEG-PGIIRMDGVTRKNAGVSIGDTV 78


                  ....*..
gi 156564401   79 EVSLYTF 85
Cdd:pfam02359  79 TVRPAEV 85

AAA

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...

538-670

6.01e-11

Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 61.24 E-value: 6.01e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401   538 SVLLEGPPHSGKTALAAKIAEESNFPF--IKICSPDKM--------------IGFSETAKCQAMKKIFDDAYKSQLSCVV 601
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGggVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPDVLI 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 156564401   602 VDDIERLLDyvpigPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNI 670
Cdd:smart00382  84 LDEITSLLD-----AEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLLI 147

AAA

ATPase family associated with various cellular activities (AAA); AAA family proteins often ...

539-668

1.64e-10

Pssm-ID: 459627 [Multi-domain] Cd Length: 130 Bit Score: 59.14 E-value: 1.64e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  539 VLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSEtakcQAMKKIFDDAYKSQLSCVVVDDIERLLdyvpiG 615
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSElvsKYVGESE----KRLRELFEAAKKLAPCVIFIDEIDALA-----G 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 156564401  616 PRFSNLVLQALLVLL------KKAPPQGRKLLIIGTTSRKDVLQEmEMLNAFSTTIHVP 668
Cdd:pfam00004  72 SRGSGGDSESRRVVNqlltelDGFTSSNSKVIVIAATNRPDKLDP-ALLGRFDRIIEFP 129

RecA-like_protease

cd19481

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...

538-652

5.70e-10

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410889 [Multi-domain] Cd Length: 158 Bit Score: 58.45 E-value: 5.70e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 538 SVLLEGPPHSGKTALAAKIAEESNFPFIKICSP---DKMIGFSEtakcQAMKKIFDDAYKSQLSCVVVDDIERlldyvpI 614
Cdd:cd19481   28 GILLYGPPGTGKTLLAKALAGELGLPLIVVKLSsllSKYVGESE----KNLRKIFERARRLAPCILFIDEIDA------I 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 156564401 615 GPRFSNLVLQALLVLLKKA------PPQGR-KLLIIGTTSRKDVL 652
Cdd:cd19481   98 GRKRDSSGESGELRRVLNQllteldGVNSRsKVLVIAATNRPDLL 142

CDC48_2

smart01072

Cell division protein 48 (CDC48) domain 2; This domain has a double psi-beta barrel fold and ...

111-183

2.49e-07

Pssm-ID: 215011 Cd Length: 64 Bit Score: 48.36 E-value: 2.49e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156564401   111 PYDTDkMAAEFIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEpatgkrqkIEVGLVVGNSQV 183
Cdd:smart01072   1 PFDGD-FAEYVKRKLLGRPVTKGDTIVVPFLGKALPFVVVSTEPSGPVIVTDD--------TEIEILEKPVEE 64

RPT1

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...

416-606

1.82e-06

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440835 [Multi-domain] Cd Length: 326 Bit Score: 50.39 E-value: 1.82e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 416 GHQLLSADVDIKELAVETKNFSGAELEGLVRAAQST-AMNRHIKASTKVEVDMEKAESLQVTRGDFLASLEndiKPafgt 494
Cdd:COG1222    1 GNDLLTIDENIKALLALIDALQERLGVELALLLQPVkALELLEEAPALLLNDANLTQKRLGTPRGTAVPAE---SP---- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 495 nQEDYASyimngIIKWGDPVTRVLddgELLVQQTKNSDR------TPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKIC 568
Cdd:COG1222   74 -DVTFDD-----IGGLDEQIEEIR---EAVELPLKNPELfrkygiEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVR 144

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 156564401 569 SPD---KMIGfsETAkcQAMKKIFDDAYKSQLSCVVVDDIE 606
Cdd:COG1222  145 GSElvsKYIG--EGA--RNVREVFELAREKAPSIIFIDEID 181

CDC48_2

pfam02933

Cell division protein 48 (CDC48), domain 2; This domain has a double psi-beta barrel fold and ...

111-159

3.19e-06

Cell division protein 48 (CDC48), domain 2; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the C-terminus. The VAT-N domain found in AAA ATPases pfam00004 is a substrate 185-residue recognition domain.

Pssm-ID: 427063 Cd Length: 64 Bit Score: 44.92 E-value: 3.19e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 156564401  111 PYDTDKMAAeFIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSI 159
Cdd:pfam02933   1 RFDGDELAY-VKRNLEGRPVSKGDTIVVEFLGGAIPLVVVSTEPSGPVV 48

hflB

PRK10733

ATP-dependent zinc metalloprotease FtsH;

539-606

1.17e-03

ATP-dependent zinc metalloprotease FtsH;

Pssm-ID: 182683 [Multi-domain] Cd Length: 644 Bit Score: 42.33 E-value: 1.17e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 156564401 539 VLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQaMKKIFDDAYKSQLSCVVVDDIE 606
Cdd:PRK10733 188 VLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASR-VRDMFEQAKKAAPCIIFIDEID 254

BREX_3_BrxF

NF033453

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...

539-610

9.27e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.

Pssm-ID: 468038 Cd Length: 149 Bit Score: 37.47 E-value: 9.27e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 156564401 539 VLLEGPPHSGKTALAAKIAEESNFPFIKICS--PDKMIGFSETAKCQAMKKIFDD-AYKSQLSCVVVDDIERLLD 610
Cdd:NF033453  19 ILLVGPPGSGKTALLRELAAKRGAPVINVNLelSRRLLELPEKQRALRAPRLLDEiAEKSSGDVVLLDNIEILFD 93

Name

Accession

Description

Interval

E-value

RecA-like_NSF-SEC18_r1-like

cd19504

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...

219-395

4.12e-130

Pssm-ID: 410912 [Multi-domain] Cd Length: 177 Bit Score: 382.99 E-value: 4.12e-130

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 219 GIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGES 298
Cdd:cd19504    1 GIGGLDKEFSDIFRRAFASRVFPPEIVEQLGCKHVKGILLYGPPGTGKTLMARQIGKMLNAREPKIVNGPEILNKYVGES 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 299 EANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDL 378
Cdd:cd19504   81 EANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRKDL 160

                        170
                 ....*....|....*..
gi 156564401 379 IDEALLRPGRLEVKMEI 395
Cdd:cd19504  161 IDEALLRPGRLEVQMEI 177

RPT1

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...

220-485

5.57e-78

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440835 [Multi-domain] Cd Length: 326 Bit Score: 253.39 E-value: 5.57e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLDKEFSDIfRRAFasrVFP---PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNA---RepkvVNGPEILNK 293
Cdd:COG1222   80 IGGLDEQIEEI-REAV---ELPlknPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGApfiR----VRGSELVSK 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 294 YVGESEANIRKLFADAEEEQRRlgansglhIIIFDEIDAICKQRGSMaGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMT 373
Cdd:COG1222  152 YIGEGARNVREVFELAREKAPS--------IIFIDEIDAIAARRTDD-GTSGEVQRTVNQLLAELDGFESRGDVLIIAAT 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 374 NRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAAQSTAM 453
Cdd:COG1222  223 NRPDLLDPALLRPGRFDRVIEVPLPDEEAREEILKIHLRDMP----LADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAI 298

                        250       260       270
                 ....*....|....*....|....*....|..
gi 156564401 454 NRHIKastkvevdmekaeslQVTRGDFLASLE 485
Cdd:COG1222  299 REGRD---------------TVTMEDLEKAIE 315

CDC48

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...

159-606

9.95e-65

Pssm-ID: 273521 [Multi-domain] Cd Length: 733 Bit Score: 229.02 E-value: 9.95e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  159 ILKGEPATGKRQKIEVGLVVGNSQVA--FEKAENSSLNLIGKAKTKENRQSIinPDWNFEKmgIGGLDKEFSDIfRRAFA 236
Cdd:TIGR01243 121 ISKGETVIVPVLEGALPFVVVSTQPAgfVYVTEATEVEIREKPVREEIERKV--PKVTYED--IGGLKEAKEKI-REMVE 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  237 SRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREpKVVNGPEILNKYVGESEANIRKLFADAEEeqrrl 316
Cdd:TIGR01243 196 LPMKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYF-ISINGPEIMSKYYGESEERLREIFKEAEE----- 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  317 ganSGLHIIIFDEIDAICKQRGSMAGStgVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIG 396
Cdd:TIGR01243 270 ---NAPSIIFIDEIDAIAPKREEVTGE--VEKRVVAQLLTLMDGLKGRGRVIVIGATNRPDALDPALRRPGRFDREIVIR 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  397 LPDEKGRLQILHIHTARMrghqLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKAST----KVEVDMEKAES 472
Cdd:TIGR01243 345 VPDKRARKEILKVHTRNM----PLAEDVDLDKLAEVTHGFVGADLAALAKEAAMAALRRFIREGKinfeAEEIPAEVLKE 420

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  473 LQVTRGDFLASLEnDIKPAFGTNqedyaSYIMNGIIKWGD-----PVTRVLDDG-ELLVQQTKNSDR---TPLVSVLLEG 543
Cdd:TIGR01243 421 LKVTMKDFMEALK-MVEPSAIRE-----VLVEVPNVRWSDiggleEVKQELREAvEWPLKHPEIFEKmgiRPPKGVLLFG 494

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156564401  544 PPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSEtakcQAMKKIFDDAYKSQLSCVVVDDIE 606
Cdd:TIGR01243 495 PPGTGKTLLAKAVATESGANFIAVRGPEilsKWVGESE----KAIREIFRKARQAAPAIIFFDEID 556

CDC48

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...

220-502

1.98e-58

Pssm-ID: 273521 [Multi-domain] Cd Length: 733 Bit Score: 211.30 E-value: 1.98e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  220 IGGLDkEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREpKVVNGPEILNKYVGESE 299
Cdd:TIGR01243 455 IGGLE-EVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANF-IAVRGPEILSKWVGESE 532

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  300 ANIRKLFADAEEeqrrlganSGLHIIIFDEIDAICKQRGSMAGSTgVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLI 379
Cdd:TIGR01243 533 KAIREIFRKARQ--------AAPAIIFFDEIDAIAPARGARFDTS-VTDRIVNQLLTEMDGIQELSNVVVIAATNRPDIL 603

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  380 DEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKA 459
Cdd:TIGR01243 604 DPALLRPGRFDRLILVPPPDEEARKEIFKIHTRSMP----LAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGS 679

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 156564401  460 STKVEVDMEKAE---SLQVTRGDFLASLENdIKPAFgtNQEDYASY 502
Cdd:TIGR01243 680 PAKEKLEVGEEEflkDLKVEMRHFLEALKK-VKPSV--SKEDMLRY 722

SpoVK

COG0464

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...

220-485

2.81e-58

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 440232 [Multi-domain] Cd Length: 397 Bit Score: 203.22 E-value: 2.81e-58

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLDKEFSDIFRRAFASRVFPpEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNArePKV-VNGPEILNKYVGES 298
Cdd:COG0464  159 LGGLEEVKEELRELVALPLKRP-ELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGL--PLIeVDLSDLVSKYVGET 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 299 EANIRKLFADAEEEqrrlgANSglhIIIFDEIDAICKQRGSMAGstGVHDTVVNQLLSKIDGVEqlNNILVIGMTNRPDL 378
Cdd:COG0464  236 EKNLREVFDKARGL-----APC---VLFIDEADALAGKRGEVGD--GVGRRVVNTLLTEMEELR--SDVVVIAATNRPDL 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 379 IDEALLRpgRLEVKMEIGLPDEKGRLQILHIHTARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMnrhik 458
Cdd:COG0464  304 LDPALLR--RFDEIIFFPLPDAEERLEIFRIHLRKRP----LDEDVDLEELAEATEGLSGADIRNVVRRAALQAL----- 372

                        250       260
                 ....*....|....*....|....*..
gi 156564401 459 astkvevdmeKAESLQVTRGDFLASLE 485
Cdd:COG0464  373 ----------RLGREPVTTEDLLEALE 389

PRK03992

proteasome-activating nucleotidase; Provisional

220-477

6.01e-54

proteasome-activating nucleotidase; Provisional

Pssm-ID: 179699 [Multi-domain] Cd Length: 389 Bit Score: 190.81 E-value: 6.01e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLDKEFSDIfRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVnGPEILNKYVGESE 299
Cdd:PRK03992 133 IGGLEEQIREV-REAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVV-GSELVQKFIGEGA 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 300 ANIRKLFADAEEEqrrlgANSglhiIIF-DEIDAICKQRGSMA--GSTGVHDTVVnQLLSKIDGVEQLNNILVIGMTNRP 376
Cdd:PRK03992 211 RLVRELFELAREK-----APS----IIFiDEIDAIAAKRTDSGtsGDREVQRTLM-QLLAEMDGFDPRGNVKIIAATNRI 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 377 DLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAAQSTA---- 452
Cdd:PRK03992 281 DILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKMN----LADDVDLEELAELTEGASGADLKAICTEAGMFAirdd 356

                        250       260       270
                 ....*....|....*....|....*....|
gi 156564401 453 -----MNRHIKASTKVEVDMEKAESLQVTR 477
Cdd:PRK03992 357 rtevtMEDFLKAIEKVMGKEEKDSMEEPGV 386

RecA-like_CDC48_r2-like

cd19511

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...

242-390

1.06e-53

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410919 [Multi-domain] Cd Length: 159 Bit Score: 182.48 E-value: 1.06e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 242 PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIgkmlnAREPKV----VNGPEILNKYVGESEANIRKLFADAeeeqrRLG 317
Cdd:cd19511   16 PDAFKRLGIRPPKGVLLYGPPGCGKTLLAKAL-----ASEAGLnfisVKGPELFSKYVGESERAVREIFQKA-----RQA 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156564401 318 ANSglhIIIFDEIDAICKQRGSmAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLE 390
Cdd:cd19511   86 APC---IIFFDEIDSLAPRRGQ-SDSSGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLD 154

pup_AAA

TIGR03689

proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some ...

211-410

4.32e-52

proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides]

Pssm-ID: 200312 [Multi-domain] Cd Length: 512 Bit Score: 189.15 E-value: 4.32e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  211 PDWNFEKmgIGGLDKEFSDIfRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKV------ 284
Cdd:TIGR03689 177 PDVTYAD--IGGLGSQIEQI-RDAVELPFLHPELYREYGLKPPKGVLLYGPPGCGKTLIAKAVANSLAARIGAEgggksy 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  285 ---VNGPEILNKYVGESEANIRKLFADAEEEqrrlgANSGLHIIIF-DEIDAICKQRGSmAGSTGVHDTVVNQLLSKIDG 360
Cdd:TIGR03689 254 flnIKGPELLNKYVGETERQIRLIFQRAREK-----ASEGRPVIVFfDEMDSLFRTRGS-GVSSDVETTVVPQLLAEIDG 327

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 156564401  361 VEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIH 410
Cdd:TIGR03689 328 VESLDNVIVIGASNREDMIDPAILRPGRLDVKIRIERPDAEAAADIFAKY 377

RecA-like_protease

cd19481

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...

229-395

8.28e-52

Pssm-ID: 410889 [Multi-domain] Cd Length: 158 Bit Score: 177.09 E-value: 8.28e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 229 DIFRRAFASRVFPPeiVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNArEPKVVNGPEILNKYVGESEANIRKLFAD 308
Cdd:cd19481    4 SLREAVEAPRRGSR--LRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGL-PLIVVKLSSLLSKYVGESEKNLRKIFER 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 309 AEEEQRrlgansglHIIIFDEIDAICKQRGSMAGStGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGR 388
Cdd:cd19481   81 ARRLAP--------CILFIDEIDAIGRKRDSSGES-GELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRPGR 151


                 ....*..
gi 156564401 389 LEVKMEI 395
Cdd:cd19481  152 FDEVIEF 158

RecA-like_CDC48_NLV2_r1-like

cd19503

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...

219-395

6.82e-49

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410911 [Multi-domain] Cd Length: 165 Bit Score: 169.39 E-value: 6.82e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 219 GIGGLDKEFsDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREpKVVNGPEILNKYVGES 298
Cdd:cd19503    1 DIGGLDEQI-ASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANF-LSISGPSIVSKYLGES 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 299 EANIRKLFADAEEEQRRlgansglhIIIFDEIDAICKQRGSmaGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDL 378
Cdd:cd19503   79 EKNLREIFEEARSHAPS--------IIFIDEIDALAPKREE--DQREVERRVVAQLLTLMDGMSSRGKVVVIAATNRPDA 148

                        170
                 ....*....|....*..
gi 156564401 379 IDEALLRPGRLEVKMEI 395
Cdd:cd19503  149 IDPALRRPGRFDREVEI 165

RecA-like_VCP_r2

cd19529

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...

242-395

3.63e-46

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410937 [Multi-domain] Cd Length: 159 Bit Score: 161.51 E-value: 3.63e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 242 PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVvNGPEILNKYVGESEANIRKLFADAEEeqrrlganSG 321
Cdd:cd19529   16 PEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISV-KGPELLSKWVGESEKAIREIFRKARQ--------VA 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156564401 322 LHIIIFDEIDAICKQRGSmAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEI 395
Cdd:cd19529   87 PCVIFFDEIDSIAPRRGT-TGDSGVTERVVNQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFDRLIYI 159

RecA-like_CDC48_r2-like

cd19528

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...

239-390

6.87e-45

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410936 [Multi-domain] Cd Length: 161 Bit Score: 158.06 E-value: 6.87e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 239 VFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIgkmlnAREPKV----VNGPEILNKYVGESEANIRKLFADAeeeqr 314
Cdd:cd19528   13 VEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAI-----ANECQAnfisVKGPELLTMWFGESEANVRDIFDKA----- 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156564401 315 RLGANSglhIIIFDEIDAICKQRG-SMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLE 390
Cdd:cd19528   83 RAAAPC---VLFFDELDSIAKARGgNIGDAGGAADRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRPGRLD 156

FtsH_fam

TIGR01241

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...

242-470

1.17e-44

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]

Pssm-ID: 273520 [Multi-domain] Cd Length: 495 Bit Score: 167.85 E-value: 1.17e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  242 PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIgkmlnAREPKV----VNGPEILNKYVGESEANIRKLFadaeeEQRRLG 317
Cdd:TIGR01241  77 PSKFTKLGAKIPKGVLLVGPPGTGKTLLAKAV-----AGEAGVpffsISGSDFVEMFVGVGASRVRDLF-----EQAKKN 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  318 ANSglhIIIFDEIDAICKQRGsmAGSTGVHDTV---VNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKME 394
Cdd:TIGR01241 147 APC---IIFIDEIDAVGRQRG--AGLGGGNDEReqtLNQLLVEMDGFGTNTGVIVIAATNRPDVLDPALLRPGRFDRQVV 221

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156564401  395 IGLPDEKGRLQILHIHTARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTkvEVDMEKA 470
Cdd:TIGR01241 222 VDLPDIKGREEILKVHAKNKK----LAPDVDLKAVARRTPGFSGADLANLLNEAALLAARKNKTEIT--MNDIEEA 291

COG1223

Predicted ATPase, AAA+ superfamily [General function prediction only];

243-452

7.12e-44

Predicted ATPase, AAA+ superfamily [General function prediction only];

Pssm-ID: 440836 [Multi-domain] Cd Length: 246 Bit Score: 158.51 E-value: 7.12e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 243 EIVEQMGCKHVKGILLYGPPGCGKTLLARQIgkmlnAREPKV----VNGPEILNKYVGESEANIRKLFADAeeEQRRLga 318
Cdd:COG1223   25 ENLRKFGLWPPRKILFYGPPGTGKTMLAEAL-----AGELKLplltVRLDSLIGSYLGETARNLRKLFDFA--RRAPC-- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 319 nsglhIIIFDEIDAICKQRGSmagSTGVHDT--VVNQLLSKIDGVEqlNNILVIGMTNRPDLIDEALLRpgRLEVKMEIG 396
Cdd:COG1223   96 -----VIFFDEFDAIAKDRGD---QNDVGEVkrVVNALLQELDGLP--SGSVVIAATNHPELLDSALWR--RFDEVIEFP 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 156564401 397 LPDEKGRLQILHIHTARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAAQSTA 452
Cdd:COG1223  164 LPDKEERKEILELNLKKFP----LPFELDLKKLAKKLEGLSGADIEKVLKTALKKA 215

RecA-like_PEX1_r2

cd19526

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...

242-390

1.18e-42

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410934 [Multi-domain] Cd Length: 158 Bit Score: 151.81 E-value: 1.18e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 242 PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVvNGPEILNKYVGESEANIRKLFADAeeeqrrlgANSG 321
Cdd:cd19526   16 PKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISV-KGPELLNKYIGASEQNVRDLFSRA--------QSAK 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 156564401 322 LHIIIFDEIDAICKQRGSmaGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLE 390
Cdd:cd19526   87 PCILFFDEFDSIAPKRGH--DSTGVTDRVVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPALLRPGRLD 153

AAA

ATPase family associated with various cellular activities (AAA); AAA family proteins often ...

256-397

1.37e-42

Pssm-ID: 459627 [Multi-domain] Cd Length: 130 Bit Score: 150.44 E-value: 1.37e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  256 ILLYGPPGCGKTLLARQIGKMLNArEPKVVNGPEILNKYVGESEANIRKLFADAEEEQrrlgansgLHIIIFDEIDAICK 335
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGA-PFIEISGSELVSKYVGESEKRLRELFEAAKKLA--------PCVIFIDEIDALAG 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156564401  336 QRGSmaGSTGVHDTVVNQLLSKIDGVEQL-NNILVIGMTNRPDLIDEALLrpGRLEVKMEIGL 397
Cdd:pfam00004  72 SRGS--GGDSESRRVVNQLLTELDGFTSSnSKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130

RecA-like_NVL_r2-like

cd19530

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...

242-390

2.36e-41

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410938 [Multi-domain] Cd Length: 161 Bit Score: 148.40 E-value: 2.36e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 242 PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIgkmlnAREPKV----VNGPEILNKYVGESEANIRKLFadaeeeQRrlG 317
Cdd:cd19530   19 PDIYKALGIDLPTGVLLYGPPGCGKTLLAKAV-----ANESGAnfisVKGPELLNKYVGESERAVRQVF------QR--A 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156564401 318 ANSGLHIIIFDEIDAICKQRGSmaGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLE 390
Cdd:cd19530   86 RASAPCVIFFDEVDALVPKRGD--GGSWASERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLD 156

HflB

COG0465

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];

243-468

4.02e-41

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440233 [Multi-domain] Cd Length: 583 Bit Score: 159.05 E-value: 4.02e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 243 EIVE---------QMGCKHVKGILLYGPPGCGKTLLARQIgkmlnAREPKV----VNGPEILNKYVGESEANIRKLFADA 309
Cdd:COG0465  156 EIVDflkdpekftRLGAKIPKGVLLVGPPGTGKTLLAKAV-----AGEAGVpffsISGSDFVEMFVGVGASRVRDLFEQA 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 310 EEEqrrlgANSglhiIIF-DEIDAICKQRGsmAGSTGVHD----TVvNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALL 384
Cdd:COG0465  231 KKN-----APC----IIFiDEIDAVGRQRG--AGLGGGHDereqTL-NQLLVEMDGFEGNEGVIVIAATNRPDVLDPALL 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 385 RPGRLEVKMEIGLPDEKGRLQILHIHTARMRghqlLSADVDIKELAVETKNFSGAELEGLV-RAAQSTAMNRhikastKV 463
Cdd:COG0465  299 RPGRFDRQVVVDLPDVKGREAILKVHARKKP----LAPDVDLEVIARRTPGFSGADLANLVnEAALLAARRN------KK 368


                 ....*
gi 156564401 464 EVDME 468
Cdd:COG0465  369 AVTME 373

RecA-like_CDC48_r1-like

cd19519

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...

220-396

4.32e-41

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410927 [Multi-domain] Cd Length: 166 Bit Score: 147.97 E-value: 4.32e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLDKEFSDIfRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREpKVVNGPEILNKYVGESE 299
Cdd:cd19519    2 IGGCRKQLAQI-REMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFF-FLINGPEIMSKLAGESE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 300 ANIRKLFADAEEeqrrlgaNSGlHIIIFDEIDAICKQRGSMAGStgVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLI 379
Cdd:cd19519   80 SNLRKAFEEAEK-------NAP-AIIFIDEIDAIAPKREKTHGE--VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSI 149

                        170
                 ....*....|....*..
gi 156564401 380 DEALLRPGRLEVKMEIG 396
Cdd:cd19519  150 DPALRRFGRFDREIDIG 166

ftsH

CHL00176

cell division protein; Validated

186-466

2.80e-40

cell division protein; Validated

Pssm-ID: 214386 [Multi-domain] Cd Length: 638 Bit Score: 157.52 E-value: 2.80e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 186 EKAENSSLNLIGKAKTKENRQSIINPDWNFEKmgIGGLD---KEFSDIfrrafASRVFPPEIVEQMGCKHVKGILLYGPP 262
Cdd:CHL00176 153 NFKGGPGQNLMNFGKSKARFQMEADTGITFRD--IAGIEeakEEFEEV-----VSFLKKPERFTAVGAKIPKGVLLVGPP 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 263 GCGKTLLARQIgkmlnAREPKV----VNGPEILNKYVGESEANIRKLFADAEEeqrrlgaNSGLhIIIFDEIDAICKQRG 338
Cdd:CHL00176 226 GTGKTLLAKAI-----AGEAEVpffsISGSEFVEMFVGVGAARVRDLFKKAKE-------NSPC-IVFIDEIDAVGRQRG 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 339 smAGSTGVHD---TVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHtARmr 415
Cdd:CHL00176 293 --AGIGGGNDereQTLNQLLTEMDGFKGNKGVIVIAATNRVDILDAALLRPGRFDRQITVSLPDREGRLDILKVH-AR-- 367

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 156564401 416 gHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVD 466
Cdd:CHL00176 368 -NKKLSPDVSLELIARRTPGFSGADLANLLNEAAILTARRKKATITMKEID 417

RecA-like_PAN_like

cd19502

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...

220-395

3.38e-40

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410910 [Multi-domain] Cd Length: 171 Bit Score: 145.56 E-value: 3.38e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLDKEFSDIfRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVnGPEILNKYVGESE 299
Cdd:cd19502    5 IGGLDEQIREI-REVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVV-GSELVQKYIGEGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 300 ANIRKLFADAEEEQRRlgansglhIIIFDEIDAICKQR--GSMAGSTGVHDTVVnQLLSKIDGVEQLNNILVIGMTNRPD 377
Cdd:cd19502   83 RLVRELFEMAREKAPS--------IIFIDEIDAIGAKRfdSGTGGDREVQRTML-ELLNQLDGFDPRGNIKVIMATNRPD 153

                        170
                 ....*....|....*...
gi 156564401 378 LIDEALLRPGRLEVKMEI 395
Cdd:cd19502  154 ILDPALLRPGRFDRKIEF 171

hflB

PRK10733

ATP-dependent zinc metalloprotease FtsH;

242-471

5.08e-39

ATP-dependent zinc metalloprotease FtsH;

Pssm-ID: 182683 [Multi-domain] Cd Length: 644 Bit Score: 153.65 E-value: 5.08e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 242 PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIgkmlnAREPKV----VNGPEILNKYVGESEANIRKLFadaeeEQRRLG 317
Cdd:PRK10733 174 PSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAI-----AGEAKVpfftISGSDFVEMFVGVGASRVRDMF-----EQAKKA 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 318 ANSglhIIIFDEIDAICKQRGsmAGSTGVHD---TVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKME 394
Cdd:PRK10733 244 APC---IIFIDEIDAVGRQRG--AGLGGGHDereQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVV 318

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156564401 395 IGLPDEKGRLQILHIHTARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEvdMEKAE 471
Cdd:PRK10733 319 VGLPDVRGREQILKVHMRRVP----LAPDIDAAIIARGTPGFSGADLANLVNEAALFAARGNKRVVSMVE--FEKAK 389

PTZ00361

26 proteosome regulatory subunit 4-like protein; Provisional

220-486

3.94e-38

26 proteosome regulatory subunit 4-like protein; Provisional

Pssm-ID: 185575 [Multi-domain] Cd Length: 438 Bit Score: 147.61 E-value: 3.94e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLDKEFSDIfRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVnGPEILNKYVGESE 299
Cdd:PTZ00361 185 IGGLEQQIQEI-KEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVV-GSELIQKYLGDGP 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 300 ANIRKLFADAEEEqrrlgANSglhIIIFDEIDAICKQR--GSMAGSTGVHDTVVnQLLSKIDGVEQLNNILVIGMTNRPD 377
Cdd:PTZ00361 263 KLVRELFRVAEEN-----APS---IVFIDEIDAIGTKRydATSGGEKEIQRTML-ELLNQLDGFDSRGDVKVIMATNRIE 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 378 LIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMnrhi 457
Cdd:PTZ00361 334 SLDPALIRPGRIDRKIEFPNPDEKTKRRIFEIHTSKMT----LAEDVDLEEFIMAKDELSGADIKAICTEAGLLAL---- 405

                        250       260
                 ....*....|....*....|....*....
gi 156564401 458 kastkvevdmeKAESLQVTRGDFLASLEN 486
Cdd:PTZ00361 406 -----------RERRMKVTQADFRKAKEK 423

RecA-like_PEX6_r2

cd19527

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...

249-390

3.63e-37

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410935 [Multi-domain] Cd Length: 160 Bit Score: 136.49 E-value: 3.63e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 249 GCKHVKGILLYGPPGCGKTLLARQIGK--MLNAREpkvVNGPEILNKYVGESEANIRKLFADAEEEQRrlgansglHIII 326
Cdd:cd19527   22 GLRKRSGILLYGPPGTGKTLLAKAIATecSLNFLS---VKGPELINMYIGESEANVREVFQKARDAKP--------CVIF 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 156564401 327 FDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQ-LNNILVIGMTNRPDLIDEALLRPGRLE 390
Cdd:cd19527   91 FDELDSLAPSRGNSGDSGGVMDRVVSQLLAELDGMSSsGQDVFVIGATNRPDLLDPALLRPGRFD 155

PTZ00454

26S protease regulatory subunit 6B-like protein; Provisional

220-470

7.29e-36

26S protease regulatory subunit 6B-like protein; Provisional

Pssm-ID: 240423 [Multi-domain] Cd Length: 398 Bit Score: 140.28 E-value: 7.29e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLDKEFSDIfRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVnGPEILNKYVGESE 299
Cdd:PTZ00454 147 IGGLDIQKQEI-REAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVV-GSEFVQKYLGEGP 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 300 ANIRKLFadaeeeqrRLGANSGLHIIIFDEIDAICKQR-GSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDL 378
Cdd:PTZ00454 225 RMVRDVF--------RLARENAPSIIFIDEVDSIATKRfDAQTGADREVQRILLELLNQMDGFDQTTNVKVIMATNRADT 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 379 IDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAA--QSTAMNRH 456
Cdd:PTZ00454 297 LDPALLRPGRLDRKIEFPLPDRRQKRLIFQTITSKMN----LSEEVDLEDFVSRPEKISAADIAAICQEAgmQAVRKNRY 372

                        250
                 ....*....|....
gi 156564401 457 IKASTkvevDMEKA 470
Cdd:PTZ00454 373 VILPK----DFEKG 382

RecA-like_FtsH

cd19501

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...

220-390

1.03e-34

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410909 [Multi-domain] Cd Length: 171 Bit Score: 130.04 E-value: 1.03e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLD------KEFSDIFRRafasrvfpPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIgkmlnAREPKV----VNGPE 289
Cdd:cd19501    6 VAGCEeakeelKEVVEFLKN--------PEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAV-----AGEAGVpffsISGSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 290 ILNKYVGESEANIRKLFADAEEEQRrlgansglHIIIFDEIDAICKQRGsmAGSTGVHDTV---VNQLLSKIDGVEQLNN 366
Cdd:cd19501   73 FVEMFVGVGASRVRDLFEQAKKNAP--------CIVFIDEIDAVGRKRG--AGLGGGHDEReqtLNQLLVEMDGFESNTG 142

                        170       180
                 ....*....|....*....|....
gi 156564401 367 ILVIGMTNRPDLIDEALLRPGRLE 390
Cdd:cd19501  143 VIVIAATNRPDVLDPALLRPGRFD 166

cell_div_CdvC

NF041006

cell division protein CdvC;

254-448

1.56e-31

cell division protein CdvC;

Pssm-ID: 468935 [Multi-domain] Cd Length: 371 Bit Score: 126.77 E-value: 1.56e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 254 KGILLYGPPGCGKTLLARQIGKMLNArEPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSglhIIIFDEIDAI 333
Cdd:NF041006 135 RGILLYGPPGCGKTMLAAAVANEIDS-EFIHVDAASIMSKWLGEAEKNVAKIFKKAREKSKEEGKPA---IIFIDEIDAL 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 334 CkqrGSMAGSTGVHDTVVNQLLSKIDGVEQLNNIL---VIGMTNRPDLIDEALLRpgRLEVKMEIGLPDEKGRLQILHIH 410
Cdd:NF041006 211 L---GVYSSEVGGEVRVRNQFLKEMDGLQDKSENYhvyVIGATNKPWRLDEPFLR--RFQKRIYIPLPDREQRLELLKYY 285

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 156564401 411 TARMRghqlLSADVDIKELAVETKNFSGAELEGLVRAA 448
Cdd:NF041006 286 TSKIK----LENDVDLDELAEMTEGYTASDIRDIVQAA 319

RecA-like_NVL_r1-like

cd19518

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...

220-397

1.01e-30

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410926 [Multi-domain] Cd Length: 169 Bit Score: 118.66 E-value: 1.01e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLDKEFSDIfRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIgkmlnAREPKV----VNGPEILNKYV 295
Cdd:cd19518    2 IGGMDSTLKEL-CELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAI-----AGELKVpflkISATEIVSGVS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 296 GESEANIRKLFADAEeeqrrlgANSGLhIIIFDEIDAICKQRGSmaGSTGVHDTVVNQLLSKIDGveqLNN-------IL 368
Cdd:cd19518   76 GESEEKIRELFDQAI-------SNAPC-IVFIDEIDAITPKRES--AQREMERRIVSQLLTCMDE---LNNektaggpVL 142

                        170       180
                 ....*....|....*....|....*....
gi 156564401 369 VIGMTNRPDLIDEALLRPGRLEvkMEIGL 397
Cdd:cd19518  143 VIGATNRPDSLDPALRRAGRFD--REICL 169

RecA-like_Yta7-like

cd19517

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...

220-390

3.84e-29

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410925 [Multi-domain] Cd Length: 170 Bit Score: 114.14 E-value: 3.84e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLDKEFSDIFRRAFasrvFP---PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVV----NGPEILN 292
Cdd:cd19517    2 IGGLSHYINQLKEMVF----FPllyPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSKGGQKVSffmrKGADCLS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 293 KYVGESEANIRKLFADAEEEQRRlgansglhIIIFDEIDAICKQRGSMAGSTgvHDTVVNQLLSKIDGVEQLNNILVIGM 372
Cdd:cd19517   78 KWVGEAERQLRLLFEEAYRMQPS--------IIFFDEIDGLAPVRSSKQEQI--HASIVSTLLALMDGLDNRGQVVVIGA 147

                        170
                 ....*....|....*...
gi 156564401 373 TNRPDLIDEALLRPGRLE 390
Cdd:cd19517  148 TNRPDALDPALRRPGRFD 165

RecA-like_VPS4-like

cd19509

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...

253-395

5.18e-28

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410917 [Multi-domain] Cd Length: 163 Bit Score: 110.52 E-value: 5.18e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 253 VKGILLYGPPGCGKTLLARQIGKMLNAREPKvVNGPEILNKYVGESEANIRKLFADAEEEQRRlgansglhIIIFDEIDA 332
Cdd:cd19509   32 PRGILLYGPPGTGKTLLARAVASESGSTFFS-ISASSLVSKWVGESEKIVRALFALARELQPS--------IIFIDEIDS 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 156564401 333 ICKQRGSmaGSTGVHDTVVNQLLSKIDGVE--QLNNILVIGMTNRPDLIDEALLRpgRLEVKMEI 395
Cdd:cd19509  103 LLSERGS--GEHEASRRVKTEFLVQMDGVLnkPEDRVLVLGATNRPWELDEAFLR--RFEKRIYI 163

AAA

cd00009

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...

254-397

1.59e-23

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.

Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 97.22 E-value: 1.59e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 254 KGILLYGPPGCGKTLLARQIGKMLNAREPKV--VNGPEILNKYVGESEANirklfADAEEEQRRLGANSGLHIIIFDEID 331
Cdd:cd00009   20 KNLLLYGPPGTGKTTLARAIANELFRPGAPFlyLNASDLLEGLVVAELFG-----HFLVRLLFELAEKAKPGVLFIDEID 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156564401 332 AIckqrgsmagSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGL 397
Cdd:cd00009   95 SL---------SRGAQNALLRVLETLNDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRIVIPL 151

RecA-like_KTNA1

cd19522

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...

254-395

1.58e-18

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410930 [Multi-domain] Cd Length: 170 Bit Score: 83.50 E-value: 1.58e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 254 KGILLYGPPGCGKTLLARQIgkmlnAREPKV----VNGPEILNKYVGESEANIRKLFadaeeEQRRLGANSglhIIIFDE 329
Cdd:cd19522   34 KGVLMVGPPGTGKTLLAKAV-----ATECGTtffnVSSSTLTSKYRGESEKLVRLLF-----EMARFYAPT---TIFIDE 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156564401 330 IDAICKQRgsmaGSTGVHDT---VVNQLLSKIDGV-------EQLNNILVIGMTNRPDLIDEALLRpgRLEVKMEI 395
Cdd:cd19522  101 IDSICSRR----GTSEEHEAsrrVKSELLVQMDGVggasendDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYI 170

RecA-like_ATAD1

cd19520

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...

220-391

3.24e-18

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410928 [Multi-domain] Cd Length: 166 Bit Score: 82.47 E-value: 3.24e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLDKEFSDIFRRAfasrVFP---PEIVEQMGC-KHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGpEILNKYV 295
Cdd:cd19520    2 IGGLDEVITELKELV----ILPlqrPELFDNSRLlQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVS-SLTDKWY 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 296 GESEANIRKLFADAEEEQRRlgansglhIIIFDEIDAICKQRgsmagSTGVHD---TVVNQLLSKIDGV--EQLNNILVI 370
Cdd:cd19520   77 GESQKLVAAVFSLASKLQPS--------IIFIDEIDSFLRQR-----SSTDHEataMMKAEFMSLWDGLstDGNCRVIVM 143

                        170       180
                 ....*....|....*....|...
gi 156564401 371 GMTNRPDLIDEALLR--PGRLEV 391
Cdd:cd19520  144 GATNRPQDLDEAILRrmPKRFHI 166

CDC48_N

smart01073

Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel ...

6-83

8.53e-18

Pssm-ID: 215012 [Multi-domain] Cd Length: 82 Bit Score: 78.42 E-value: 8.53e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401     6 MQAARCPTDELSLTNCAVVNEKDFQS-----GQHVIVRtspNHRYTFTLK--THPSVVPGSIAFSLPQRKWAGLSIGQEI 78
Cdd:smart01073   1 LRVAEAPSDEDVGRGIARLSPEDMDElglfpGDYVLIT---GKRRTVAIVwpAYPEDPGGIIRIDGVQRKNAGVSIGDTV 77


                   ....*
gi 156564401    79 EVSLY 83
Cdd:smart01073  78 TVRKA 82

RecA-like_Figl-1

cd19525

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...

254-395

1.81e-17

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410933 [Multi-domain] Cd Length: 186 Bit Score: 81.19 E-value: 1.81e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 254 KGILLYGPPGCGKTLLARQIGKMLNAREPKvVNGPEILNKYVGESEANIRKLFADAEEEQRRlgansglhIIIFDEIDAI 333
Cdd:cd19525   56 KGILLFGPPGTGKTLIGKCIASQSGATFFS-ISASSLTSKWVGEGEKMVRALFSVARCKQPA--------VIFIDEIDSL 126

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156564401 334 CKQRGSmagstGVHDT---VVNQLLSKIDGVEQLNN--ILVIGMTNRPDLIDEALLRpgRLEVKMEI 395
Cdd:cd19525  127 LSQRGE-----GEHESsrrIKTEFLVQLDGATTSSEdrILVVGATNRPQEIDEAARR--RLVKRLYI 186

RecA-like_spastin

cd19524

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...

254-385

7.05e-17

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410932 [Multi-domain] Cd Length: 164 Bit Score: 78.74 E-value: 7.05e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 254 KGILLYGPPGCGKTLLARQIgkmlnAREPKV----VNGPEILNKYVGESEANIRKLFADAEEEQRRlgansglhIIIFDE 329
Cdd:cd19524   34 RGLLLFGPPGNGKTMLAKAV-----AAESNAtffnISAASLTSKYVGEGEKLVRALFAVARELQPS--------IIFIDE 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156564401 330 IDAICKQRgsmagSTGVHDT---VVNQLLSKIDGVEQLNN--ILVIGMTNRPDLIDEALLR 385
Cdd:cd19524  101 VDSLLSER-----SEGEHEAsrrLKTEFLIEFDGVQSNGDdrVLVMGATNRPQELDDAVLR 156

RecA-like_VPS4

cd19521

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...

254-395

9.59e-16

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410929 [Multi-domain] Cd Length: 170 Bit Score: 75.67 E-value: 9.59e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 254 KGILLYGPPGCGKTLLARQIGKMLNAREPKvVNGPEILNKYVGESEANIRKLFADAEEEQRRlgansglhIIIFDEIDAI 333
Cdd:cd19521   41 SGILLYGPPGTGKSYLAKAVATEANSTFFS-VSSSDLVSKWMGESEKLVKQLFAMARENKPS--------IIFIDEVDSL 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156564401 334 CKQRGSmaGSTGVHDTVVNQLLSKIDGVEQLNN-ILVIGMTNRPDLIDEALLRpgRLEVKMEI 395
Cdd:cd19521  112 CGTRGE--GESEASRRIKTELLVQMNGVGNDSQgVLVLGATNIPWQLDSAIRR--RFEKRIYI 170

AAA

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...

254-399

3.26e-15

Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 73.56 E-value: 3.26e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401   254 KGILLYGPPGCGKTLLARQIGKMLNAREPKVV----------------NGPEILNKYVGESEANIRKLFADAEEEQRRlg 317
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPGGGVIyidgedileevldqllLIIVGGKKASGSGELRLRLALALARKLKPD-- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401   318 ansglhIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKidgveqlNNILVIGMTNRPDLIDEALLRPgRLEVKMEIGL 397
Cdd:smart00382  81 ------VLILDEITSLLDAEQEALLLLLEELRLLLLLKSE-------KNLTVILTTNDEKDLGPALLRR-RFDRRIVLLL 146


                   ..
gi 156564401   398 PD 399
Cdd:smart00382 147 IL 148

CDC48_N

pfam02359

Cell division protein 48 (CDC48), N-terminal domain; This domain has a double psi-beta barrel ...

5-85

5.57e-14

Pssm-ID: 426738 Cd Length: 85 Bit Score: 67.61 E-value: 5.57e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401    5 SMQAARCPtDELSLTNCAVVNEKDFQS--GQHVIVRTSPNHRYT----FTLKTHPSVvPGSIAFSLPQRKWAGLSIGQEI 78
Cdd:pfam02359   1 RLRVAEAP-DRDVGRGIARLNPEDMEElgLFPGDVVEIKGKRKTvaivWSAYPEDEG-PGIIRMDGVTRKNAGVSIGDTV 78


                  ....*..
gi 156564401   79 EVSLYTF 85
Cdd:pfam02359  79 TVRPAEV 85

ycf46

CHL00195

Ycf46; Provisional

254-454

4.53e-12

Ycf46; Provisional

Pssm-ID: 177094 [Multi-domain] Cd Length: 489 Bit Score: 68.89 E-value: 4.53e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 254 KGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGpEILNKYVGESEANIRKLFADAEeeqrrlgansGLH--IIIFDEID 331
Cdd:CHL00195 260 RGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVG-KLFGGIVGESESRMRQMIRIAE----------ALSpcILWIDEID 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 332 AiCKQRGSMAGSTGVHDTVVNQLLSKIDgvEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHT 411
Cdd:CHL00195 329 K-AFSNSESKGDSGTTNRVLATFITWLS--EKKSPVFVVATANNIDLLPLEILRKGRFDEIFFLDLPSLEEREKIFKIHL 405

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 156564401 412 ARMRGHQLlsADVDIKELAVETKNFSGAELEGLVRAAQSTAMN 454
Cdd:CHL00195 406 QKFRPKSW--KKYDIKKLSKLSNKFSGAEIEQSIIEAMYIAFY 446

RecA-like_Pch2-like

cd19508

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...

256-383

9.30e-12

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion

Pssm-ID: 410916 [Multi-domain] Cd Length: 199 Bit Score: 64.78 E-value: 9.30e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 256 ILLYGPPGCGKT----LLARQIGKMLNAREPKV----VNGPEILNKYVGESEANIRKLFADAEEEQRRLGAnsgLHIIIF 327
Cdd:cd19508   55 VLLHGPPGTGKTslckALAQKLSIRLSSRYRYGqlieINSHSLFSKWFSESGKLVTKMFQKIQELIDDKDA---LVFVLI 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 156564401 328 DEIDAICKQRGSMAGSTGVHDT--VVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEAL 383
Cdd:cd19508  132 DEVESLAAARSASSSGTEPSDAirVVNAVLTQIDRIKRYHNNVILLTSNLLEKIDVAF 189

AAA

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...

538-670

6.01e-11

Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 61.24 E-value: 6.01e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401   538 SVLLEGPPHSGKTALAAKIAEESNFPF--IKICSPDKM--------------IGFSETAKCQAMKKIFDDAYKSQLSCVV 601
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGggVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPDVLI 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 156564401   602 VDDIERLLDyvpigPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNI 670
Cdd:smart00382  84 LDEITSLLD-----AEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLLI 147

RecA-like_BCS1

cd19510

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...

254-395

8.57e-11

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410918 [Multi-domain] Cd Length: 153 Bit Score: 60.83 E-value: 8.57e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 254 KGILLYGPPGCGKTLLARQIGKMLNarepkvvngpeiLNKYVGE-SEANirklfaDAEEEQRRLGANSG-LHIIIFDEID 331
Cdd:cd19510   24 RGYLLYGPPGTGKSSFIAALAGELD------------YDICDLNlSEVV------LTDDRLNHLLNTAPkQSIILLEDID 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 156564401 332 AICKQR---GSMAGSTGVHDTV-VNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEI 395
Cdd:cd19510   86 AAFESRehnKKNPSAYGGLSRVtFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153

RecA-like_Ycf46-like

cd19507

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...

220-388

1.22e-10

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410915 [Multi-domain] Cd Length: 161 Bit Score: 60.46 E-value: 1.22e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 220 IGGLD--KEFSDIFRRAFASRVFppeiveQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGpEILNKYVGE 297
Cdd:cd19507    2 VGGLDnlKDWLKKRKAAFSKQAS------AYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMG-RLFGGLVGE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 298 SEANIRKLFADAEEeqrrlganSGLHIIIFDEIDAiCKQRGSMAGSTGVHDTVVNQLLSKIDgvEQLNNILVIGMTNRPD 377
Cdd:cd19507   75 SESRLRQMIQTAEA--------IAPCVLWIDEIEK-GFSNADSKGDSGTSSRVLGTFLTWLQ--EKKKPVFVVATANNVQ 143

                        170
                 ....*....|.
gi 156564401 378 LIDEALLRPGR 388
Cdd:cd19507  144 SLPPELLRKGR 154

AAA

ATPase family associated with various cellular activities (AAA); AAA family proteins often ...

539-668

1.64e-10

Pssm-ID: 459627 [Multi-domain] Cd Length: 130 Bit Score: 59.14 E-value: 1.64e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  539 VLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSEtakcQAMKKIFDDAYKSQLSCVVVDDIERLLdyvpiG 615
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSElvsKYVGESE----KRLRELFEAAKKLAPCVIFIDEIDALA-----G 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 156564401  616 PRFSNLVLQALLVLL------KKAPPQGRKLLIIGTTSRKDVLQEmEMLNAFSTTIHVP 668
Cdd:pfam00004  72 SRGSGGDSESRRVVNqlltelDGFTSSNSKVIVIAATNRPDKLDP-ALLGRFDRIIEFP 129

RecA-like_fidgetin

cd19523

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...

254-385

2.00e-10

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410931 [Multi-domain] Cd Length: 163 Bit Score: 59.90 E-value: 2.00e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 254 KGILLYGPPGCGKTLLARQIGKMLNAREPKvVNGPEILNKYVGESEANIRKLFADAEEEQRRlgansglhIIIFDEIDAI 333
Cdd:cd19523   34 RSILLFGPRGTGKTLLGRCLASQLGATFLR-LRGSTLVAKWAGEGEKILQASFLAARCRQPS--------VLFISDLDAL 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 156564401 334 CKQRGSMAGSTGVHDTvvnQLLSKIDGV--EQLNNILVIGMTNRPDLIDEALLR 385
Cdd:cd19523  105 LSSQDDEASPVGRLQV---ELLAQLDGVlgSGEDGVLVVCTTSKPEEIDESLRR 155

RecA-like_protease

cd19481

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...

538-652

5.70e-10

Pssm-ID: 410889 [Multi-domain] Cd Length: 158 Bit Score: 58.45 E-value: 5.70e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 538 SVLLEGPPHSGKTALAAKIAEESNFPFIKICSP---DKMIGFSEtakcQAMKKIFDDAYKSQLSCVVVDDIERlldyvpI 614
Cdd:cd19481   28 GILLYGPPGTGKTLLAKALAGELGLPLIVVKLSsllSKYVGESE----KNLRKIFERARRLAPCILFIDEIDA------I 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 156564401 615 GPRFSNLVLQALLVLLKKA------PPQGR-KLLIIGTTSRKDVL 652
Cdd:cd19481   98 GRKRDSSGESGELRRVLNQllteldGVNSRsKVLVIAATNRPDLL 142

AAA_lid_3

pfam17862

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...

423-466

5.56e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.

Pssm-ID: 465537 [Multi-domain] Cd Length: 45 Bit Score: 52.16 E-value: 5.56e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 156564401  423 DVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVD 466
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEAVTQEDLE 44

RecA-like_NVL_r1-like

cd19518

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...

539-652

9.60e-09

Pssm-ID: 410926 [Multi-domain] Cd Length: 169 Bit Score: 55.10 E-value: 9.60e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 539 VLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKcQAMKKIFDDAYKSQLSCVVVDDIErlldyvPIGPRF 618
Cdd:cd19518   37 VLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESE-EKIRELFDQAISNAPCIVFIDEID------AITPKR 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 156564401 619 SNLVLQALLV----------LLKKAPPQGRKLLIIGTTSRKDVL 652
Cdd:cd19518  110 ESAQREMERRivsqlltcmdELNNEKTAGGPVLVIGATNRPDSL 153

RecA-like_CDC48_NLV2_r1-like

cd19503

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...

534-608

2.50e-08

Pssm-ID: 410911 [Multi-domain] Cd Length: 165 Bit Score: 53.83 E-value: 2.50e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 156564401 534 TPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSEtakcQAMKKIFDDAYKSQLSCVVVDDIERL 608
Cdd:cd19503   32 KPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSivsKYLGESE----KNLREIFEEARSHAPSIIFIDEIDAL 105

AAA

cd00009

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...

532-668

2.65e-08

Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 53.69 E-value: 2.65e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 532 DRTPLVSVLLEGPPHSGKTALAAKIAEES---NFPFIKICSPDKMIG--FSETAKCQAMKKIFDDAYKSQLSCVVVDDIE 606
Cdd:cd00009   15 ELPPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGlvVAELFGHFLVRLLFELAEKAKPGVLFIDEID 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156564401 607 RLldyvpigPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEML-NAFSTTIHVP 668
Cdd:cd00009   95 SL-------SRGAQNALLRVLETLNDLRIDRENVRVIGATNRPLLGDLDRALyDRLDIRIVIP 150

RecA-like_VPS4-like

cd19509

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...

532-609

4.25e-08

Pssm-ID: 410917 [Multi-domain] Cd Length: 163 Bit Score: 53.12 E-value: 4.25e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 532 DRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSEtakcQAMKKIFDDAYKSQLSCVVVDDIERL 608
Cdd:cd19509   28 LRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSlvsKWVGESE----KIVRALFALARELQPSIIFIDEIDSL 103


                 .
gi 156564401 609 L 609
Cdd:cd19509  104 L 104

RecA-like_CDC48_r1-like

cd19519

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...

534-606

2.34e-07

Pssm-ID: 410927 [Multi-domain] Cd Length: 166 Bit Score: 51.28 E-value: 2.34e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156564401 534 TPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSEtakcQAMKKIFDDAYKSQLSCVVVDDIE 606
Cdd:cd19519   32 KPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEimsKLAGESE----SNLRKAFEEAEKNAPAIIFIDEID 103

CDC48_2

smart01072

Cell division protein 48 (CDC48) domain 2; This domain has a double psi-beta barrel fold and ...

111-183

2.49e-07

Pssm-ID: 215011 Cd Length: 64 Bit Score: 48.36 E-value: 2.49e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156564401   111 PYDTDkMAAEFIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEpatgkrqkIEVGLVVGNSQV 183
Cdd:smart01072   1 PFDGD-FAEYVKRKLLGRPVTKGDTIVVPFLGKALPFVVVSTEPSGPVIVTDD--------TEIEILEKPVEE 64

RecA-like_VCP_r2

cd19529

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...

534-608

3.40e-07

Pssm-ID: 410937 [Multi-domain] Cd Length: 159 Bit Score: 50.57 E-value: 3.40e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 156564401 534 TPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSEtakcQAMKKIFDDAYKSQLSCVVVDDIERL 608
Cdd:cd19529   25 RPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPEllsKWVGESE----KAIREIFRKARQVAPCVIFFDEIDSI 98

RecA-like_ClpX

cd19497

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...

256-358

6.48e-07

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

Pssm-ID: 410905 [Multi-domain] Cd Length: 251 Bit Score: 51.45 E-value: 6.48e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401 256 ILLYGPPGCGKTLLARQIGKMLNArePKVVNGPEILNK--YVGESEANI-RKLFADAEEEQRRlgANSGlhIIIFDEIDA 332
Cdd:cd19497   53 ILLIGPTGSGKTLLAQTLAKILDV--PFAIADATTLTEagYVGEDVENIlLKLLQAADYDVER--AQRG--IVYIDEIDK 126

                         90       100
                 ....*....|....*....|....*.
gi 156564401 333 ICKQRGSMAGSTGVHDTVVNQLLSKI 358
Cdd:cd19497  127 IARKSENPSITRDVSGEGVQQALLKI 152

AAA_5

pfam07728

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...

255-385

1.03e-06

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.

Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 48.44 E-value: 1.03e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156564401  255 GILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEilnkyvGESEANIRKLFA-DAEEEQRRLG-----ANSGlHIIIFD 328
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSNRPVFYVQLTR------DTTEEDLFGRRNiDPGGASWVDGplvraAREG-EIAVLD 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156564401  329 EIDAIckqrgsmagstgvHDTVVNQLLSKID--------GVE----QLNNILVIGMTNRPDL----IDEALLR 385
Cdd:pfam07728  74 EINRA-------------NPDVLNSLLSLLDerrlllpdGGElvkaAPDGFRLIATMNPLDRglneLSPALRS 133

RPT1