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Conserved domains on  [gi|312836811|ref|NP_005676|]
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general transcription factor II-I repeat domain-containing protein 1 isoform 2 [Homo sapiens]

Protein Classification

GTF2I repeat domain-containing protein( domain architecture ID 10502974)

GTF2I repeat domain-containing protein may be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 128-202 1.79e-35

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 128.89  E-value: 1.79e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312836811  128 LRKMVEEVFDVLYSEALGRASVVPLPYERLLREPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKR 202
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 565-639 1.11e-34

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 126.58  E-value: 1.11e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312836811  565 LRKQVELLFNTRYAKAIGISEPVKVPYSKFLMHPEELFVVGLPEGISLRRPNCFGIAKLRKILEASNSIQFVIKR 639
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 787-859 2.94e-32

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 119.64  E-value: 2.94e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312836811  787 LREQVKELFNEKYGEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVI 859
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVI 73
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 690-764 1.30e-28

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 109.24  E-value: 1.30e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312836811  690 LREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKPCTFGSQNLERILAVADKIKFTVTR 764
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 351-425 5.03e-28

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 107.70  E-value: 5.03e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312836811  351 LRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKR 425
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
 
Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 128-202 1.79e-35

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 128.89  E-value: 1.79e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312836811  128 LRKMVEEVFDVLYSEALGRASVVPLPYERLLREPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKR 202
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 565-639 1.11e-34

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 126.58  E-value: 1.11e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312836811  565 LRKQVELLFNTRYAKAIGISEPVKVPYSKFLMHPEELFVVGLPEGISLRRPNCFGIAKLRKILEASNSIQFVIKR 639
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 787-859 2.94e-32

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 119.64  E-value: 2.94e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312836811  787 LREQVKELFNEKYGEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVI 859
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVI 73
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 690-764 1.30e-28

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 109.24  E-value: 1.30e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312836811  690 LREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKPCTFGSQNLERILAVADKIKFTVTR 764
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 351-425 5.03e-28

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 107.70  E-value: 5.03e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312836811  351 LRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKR 425
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
 
Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 128-202 1.79e-35

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 128.89  E-value: 1.79e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312836811  128 LRKMVEEVFDVLYSEALGRASVVPLPYERLLREPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKR 202
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 565-639 1.11e-34

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 126.58  E-value: 1.11e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312836811  565 LRKQVELLFNTRYAKAIGISEPVKVPYSKFLMHPEELFVVGLPEGISLRRPNCFGIAKLRKILEASNSIQFVIKR 639
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 787-859 2.94e-32

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 119.64  E-value: 2.94e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312836811  787 LREQVKELFNEKYGEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVI 859
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVI 73
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 690-764 1.30e-28

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 109.24  E-value: 1.30e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312836811  690 LREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKPCTFGSQNLERILAVADKIKFTVTR 764
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 351-425 5.03e-28

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 107.70  E-value: 5.03e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312836811  351 LRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKR 425
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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