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Conserved domains on  [gi|33695107|ref|NP_005674|]
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G-protein coupled receptor 55 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606894)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
21-299 8.26e-133

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


:

Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 378.60  E-value: 8.26e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  21 TLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRwpdyAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPF-PSLCTLVEC 99
Cdd:cd15165   1 SLQLVVYIPTFVLGLLLNLMALWVFLFKIKKW----TESTIYMINLALNDLLLLLSLPFKMHSSKKQWPLgRTLCSFLES 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 100 LYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKV-EKYMCFHNMSDDTWS 178
Cdd:cd15165  77 LYFVNMYGSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHDKPtNNTRCFHGFSNKTWS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 179 AKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIV 258
Cdd:cd15165 157 KKVIVVVEEFGFLIPMAVMVFCSVQIIRTLLDMRRPEQPKVKQNKSVKIVLSNLVVFLVCFTPYHLGIFLQFLVKNDIIN 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 33695107 259 ECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNI 299
Cdd:cd15165 237 DCSTKQSIRLFVQVSMCLANVNCCLDAICYYFILKEFRESA 277
 
Name Accession Description Interval E-value
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
21-299 8.26e-133

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 378.60  E-value: 8.26e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  21 TLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRwpdyAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPF-PSLCTLVEC 99
Cdd:cd15165   1 SLQLVVYIPTFVLGLLLNLMALWVFLFKIKKW----TESTIYMINLALNDLLLLLSLPFKMHSSKKQWPLgRTLCSFLES 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 100 LYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKV-EKYMCFHNMSDDTWS 178
Cdd:cd15165  77 LYFVNMYGSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHDKPtNNTRCFHGFSNKTWS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 179 AKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIV 258
Cdd:cd15165 157 KKVIVVVEEFGFLIPMAVMVFCSVQIIRTLLDMRRPEQPKVKQNKSVKIVLSNLVVFLVCFTPYHLGIFLQFLVKNDIIN 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 33695107 259 ECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNI 299
Cdd:cd15165 237 DCSTKQSIRLFVQVSMCLANVNCCLDAICYYFILKEFRESA 277
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
58-288 2.76e-32

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 120.48  E-value: 2.76e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107    58 ATSIYMINLAVFDLLL-VLSLPFKMV--LSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:pfam00001  18 PTNIFLLNLAVADLLFsLLTLPFWLVyyLNHGDWPFGSaLCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKRRR 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107   134 SPRKIFGICCTIWVLVWTGSIPIYSFHGKVEK-----YMCFHNMSDDTWSAKVF-FPLEVFGFLLPMGIMGFCCSRSIHI 207
Cdd:pfam00001  98 TPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpegnvTVCFIDFPEDLSKPVSYtLLISVLGFLLPLLVILVCYTLIIRT 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107   208 LL---GRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLqflvrNSFIVECRAKQSISFFLQLSMCFSNVNCCLD 284
Cdd:pfam00001 178 LRksaSKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLL-----DSLALDCELSRLLDKALSVTLWLAYVNSCLN 252

                  ....
gi 33695107   285 VFCY 288
Cdd:pfam00001 253 PIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
59-301 2.86e-24

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 100.62  E-value: 2.86e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107   59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQ--SPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:PHA03087  74 MDIYLLNLAVSDLLFVMTLPFQIYYYILFqwSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVK 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  137 KIFGICCTIWVLVWTGSIPIYSF------HGKVEKYMcFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLG 210
Cdd:PHA03087 154 YGYIVSLVIWIISIIETTPILFVyttkkdHETLICCM-FYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKILITLKG 232
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  211 RRDHTQDwvqqKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYF 290
Cdd:PHA03087 233 INKSKKN----KKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAF 308
                        250
                 ....*....|.
gi 33695107  291 VIKEFRMNIRA 301
Cdd:PHA03087 309 VSEFFNKHKKK 319
 
Name Accession Description Interval E-value
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
21-299 8.26e-133

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 378.60  E-value: 8.26e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  21 TLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRwpdyAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPF-PSLCTLVEC 99
Cdd:cd15165   1 SLQLVVYIPTFVLGLLLNLMALWVFLFKIKKW----TESTIYMINLALNDLLLLLSLPFKMHSSKKQWPLgRTLCSFLES 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 100 LYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKV-EKYMCFHNMSDDTWS 178
Cdd:cd15165  77 LYFVNMYGSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHDKPtNNTRCFHGFSNKTWS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 179 AKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIV 258
Cdd:cd15165 157 KKVIVVVEEFGFLIPMAVMVFCSVQIIRTLLDMRRPEQPKVKQNKSVKIVLSNLVVFLVCFTPYHLGIFLQFLVKNDIIN 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 33695107 259 ECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNI 299
Cdd:cd15165 237 DCSTKQSIRLFVQVSMCLANVNCCLDAICYYFILKEFRESA 277
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
21-299 1.92e-123

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 354.84  E-value: 1.92e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  21 TLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRwpdyAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPF-PSLCTLVEC 99
Cdd:cd15923   1 LLQYAIYIPTFVLGLLLNILALWVFCWRLKKW----TETNIYMTNLAVADLLLLISLPFKMHSYRRESAGlQKLCNFVLS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 100 LYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMsDDTWSA 179
Cdd:cd15923  77 LYYINMYVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLLDSSNEKTMCFQRT-KQTESL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 180 KVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFivE 259
Cdd:cd15923 156 KVFLLLEIFGFLLPLIIMTFCSARVIHTLQKRLDDVGSRSETKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVGKSY--S 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 33695107 260 CRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNI 299
Cdd:cd15923 234 CDSKLIIHFFLQSAFCLSDMNCCLDAFCYYFATKEFREAY 273
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
21-299 6.22e-80

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 244.48  E-value: 6.22e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  21 TLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRwpdyAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSP---FPSLCTLV 97
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKR----SPTTIYMINLALADLLFVLTLPFRIYYYLNGGWwpfGDFLCRLT 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  98 ECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKV----EKYMCFHNMS 173
Cdd:cd14982  77 GLLFYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIakenNSTTCFEFLS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 174 D-DTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLV 252
Cdd:cd14982 157 EwLASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLV 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 33695107 253 RNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNI 299
Cdd:cd14982 237 RLSFIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
21-295 6.28e-56

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 182.46  E-value: 6.28e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  21 TLQFAVHIPTFVLGLLLNLLAIHGFSTFLKnRWPDyaaTSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLVECL 100
Cdd:cd15164   1 LIQLIIYIPILFFGLLFNVLALWVFCCKMK-KWTE---TRVYMINLAVADCCLLFSLPFVLYFLKHSWPDDELCLVLQSI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 101 YFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFhGKVEKYMCFHNMSDDTWSAK 180
Cdd:cd15164  77 YFINRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVLVIISVSLRLAW-EEQEENFCFGKTSTRPSKRT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 181 VFFPLevFGFLLPMGIMGFCcsrSIHIL--LGRRDHTQDWVQ---QKAcIYSIAASLAVFVVSFLPVHLGFFLQFlVRNS 255
Cdd:cd15164 156 LIFSL--LGFFIPLIILSFC---SIQVIrsLKKKKKTNPHEEkliQKA-IYIVSANLIVFIVCFLPLHIGLLVRF-VMES 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 33695107 256 FIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEF 295
Cdd:cd15164 229 NKASCSLIQNIRNFIYVASCLANANCCLDAICYYFVAKEF 268
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
58-288 2.76e-32

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 120.48  E-value: 2.76e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107    58 ATSIYMINLAVFDLLL-VLSLPFKMV--LSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:pfam00001  18 PTNIFLLNLAVADLLFsLLTLPFWLVyyLNHGDWPFGSaLCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKRRR 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107   134 SPRKIFGICCTIWVLVWTGSIPIYSFHGKVEK-----YMCFHNMSDDTWSAKVF-FPLEVFGFLLPMGIMGFCCSRSIHI 207
Cdd:pfam00001  98 TPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpegnvTVCFIDFPEDLSKPVSYtLLISVLGFLLPLLVILVCYTLIIRT 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107   208 LL---GRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLqflvrNSFIVECRAKQSISFFLQLSMCFSNVNCCLD 284
Cdd:pfam00001 178 LRksaSKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLL-----DSLALDCELSRLLDKALSVTLWLAYVNSCLN 252

                  ....
gi 33695107   285 VFCY 288
Cdd:pfam00001 253 PIIY 256
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
31-290 5.63e-31

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 117.65  E-value: 5.63e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  31 FVLGLLLNLLAIHGFSTFLKNRwpdyAATSIYMINLAVFDLLLVLSLPFKMVLSQVQS-PFPS-LCTLVECLYFVSMYGS 108
Cdd:cd15156  11 FVLGLIANCVAIYIFMCTLKVR----NETTTYMINLAISDLLFVFTLPFRIFYFVQRNwPFGDlLCKISVTLFYTNMYGS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 109 VFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSF-----HGKVEKYMCFHNMSDDTWS---AK 180
Cdd:cd15156  87 ILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFqstnnQLNNNSETCFENFSSKTWKtylSK 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 181 VFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVEC 260
Cdd:cd15156 167 IVIFIEIVGFFIPLILNVTCSTMVLKTLRRPNTLSRSKLNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVRTQTFKNC 246
                       250       260       270
                ....*....|....*....|....*....|
gi 33695107 261 RAKQSISFFLQLSMCFSNVNCCLDVFCYYF 290
Cdd:cd15156 247 SVVAAVRTMYPITLCIAVSNCCFDPIVYYF 276
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
60-296 7.22e-31

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 117.56  E-value: 7.22e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLLVLSLPFKM-VLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15154  36 SIYMCNLALSDLLFTLSLPLRIyYYANHYWPFGNfLCQFSGSIFQMNMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKV 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHGK-------VEKYMCFHNMSDDTWsaKVFFPL----EVFGFLLPMGIMGFCcsrSIH 206
Cdd:cd15154 116 ARLLCLAVWALILGGSVPAAIVHSSsdcllhgEKVYRCFESFSDNDW--KGLLPLvvlaEILGFLLPLAAVLYC---SCR 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 207 IL--LGRRDHTQDWVQQKAcIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFI-VECRAKQSISFFLQLSMCFSNVNCCL 283
Cdd:cd15154 191 IFveLCRTQEPQQGRRRKT-VRLLLVNLVIFLICFVPYNTTLAVYGLLRANLVeDTWNIKDTLRKVLSVTVLLASTNCAL 269
                       250
                ....*....|...
gi 33695107 284 DVFCYYFVIKEFR 296
Cdd:cd15154 270 DPLVYYFSTEGFR 282
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
59-296 1.04e-30

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 116.94  E-value: 1.04e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLS-QVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15155  35 TAIFMTNLAVSDLLFVFTLPFKIFYNfNRHWPFgDSLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRR 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSF---HGKVEKYMCFHNMSDDTWS---AKVFFPLEVFGFLLPMGIMGFCCSRSIHILLG 210
Cdd:cd15155 115 NSAIVCAGVWILVLSGGISASLFsttNVSNTSTTCFEGFSKSIWKtylSKITIFIEVVGFIIPLLLNLTCSSLVLRTLRK 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 211 RRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYF 290
Cdd:cd15155 195 PATLSQIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYALVRSQAIANCGVERFARTMYPITLCLATLNCCFDPFVYYF 274

                ....*.
gi 33695107 291 VIKEFR 296
Cdd:cd15155 275 TSESFQ 280
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
59-296 1.93e-30

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 116.16  E-value: 1.93e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd14984  35 TDVYLLNLALADLLFVLTLPFWAVYAADGWVFGSfLCKLVSALYTINFYSGILFLACISIDRYLAIVHAVSALRARTLLH 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHGKVE---KYMC---FHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGR 211
Cdd:cd14984 115 GKLTCLGVWALALLLSLPEFIFSQVSEengSSICsydYPEDTATTWKTLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRA 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 212 RDHtqdwvQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVR-NSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYF 290
Cdd:cd14984 195 RNH-----KKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQLlGIISRSCELSKSLDYALQVTESLAFSHCCLNPVLYAF 269

                ....*.
gi 33695107 291 VIKEFR 296
Cdd:cd14984 270 VGVKFR 275
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
61-296 7.81e-28

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 109.43  E-value: 7.81e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQS-PF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKI 138
Cdd:cd15152  37 IFMINLAIADLLQVLSLPLRIFYYLNKSwPFgKFLCMFCFYLKYVNMYASIYFLVCISVRRCLYLIYPFRYNDCKRKCDV 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 139 FgICCTIWVLVWTGSI--PIYSFHGKVEKYMCFHNMS----DDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRR 212
Cdd:cd15152 117 Y-ISIAGWLVVCVGCLpfPLLRQSQDTNPTCCFADLPlrnvGLTTSVIMLTIAELTGFVTPLLIVLYCSWKTVMSLREKT 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 213 DHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVI 292
Cdd:cd15152 196 PVLQDLGEKKKALKMILTCAVVFLICFAPYHISFPLDFLVKSNKIKSCTARKVILIFHPVALCLASLNSCLDPVIYYFTT 275

                ....
gi 33695107 293 KEFR 296
Cdd:cd15152 276 DEFK 279
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
60-296 1.25e-26

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 105.92  E-value: 1.25e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLLVLSLPFKMV--LSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd14985  36 DIFIANLAAADLVFVLTLPLWATytANQYDWPFgAFLCKVSSYVISVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRR 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSFHG-----KVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGR 211
Cdd:cd14985 116 QARVTCALIWVVACLLSLPTFLLRSlqaieNLNKTACIMLYPHEAWHFGLSLELNILGFVLPLLIILTCYFHIARSLRKR 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 212 RDHTQDWVQQKACIYSIAASLAV-FVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYF 290
Cdd:cd14985 196 YERTGKNGRKRRKSLKIIFALVVaFLVCWLPFHFFKFLDFLAQLGAIRPCFWELFLDLGLPIATCLAFTNSCLNPFIYVF 275

                ....*.
gi 33695107 291 VIKEFR 296
Cdd:cd14985 276 VDRRFR 281
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
58-296 8.19e-26

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 103.97  E-value: 8.19e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15159  34 STTLYLINLAVSDILFTLALPGRIAYYALGFDWPfgdWLCRLTALLFYINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRK 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPIYSF---HGKVEKYMC--FHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHIL- 208
Cdd:cd15159 114 VKVVRYICVFVWVLVFLQTLPLLFMpmtKEMGGRITCmeYPNFEKIKRLPLILLGACVIGFGVPVGIILFCYSQITLKLc 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 209 -LGRRDHTQD--WVQQKACIySIAASLAVFVVSFLPVHLGfFLQFLVRN-SFIVECRAKQSISFFLQLSMCFSNVNCCLD 284
Cdd:cd15159 194 rTAKENPLTEksGHHKKACN-VILLVLLVFVVCFSPYHLN-IIQFMIRKlLYQPSCSELKAFKISLQITVCLMNLNCCLD 271
                       250
                ....*....|..
gi 33695107 285 VFCYYFVIKEFR 296
Cdd:cd15159 272 PFIYFFACKGYK 283
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
25-297 1.35e-25

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 103.17  E-value: 1.35e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  25 AVHIPTFVLGLLLNLLAIHGFSTFLKNrwpdYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLY 101
Cdd:cd15168   5 IVYGVVFLVGLLLNSVVLYRFIFHLKP----WNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIfgdFMCKLVRFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 102 FVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSF---HGKVEKYMCFHNMSDDTWS 178
Cdd:cd15168  81 YFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFattGRKNNRTTCYDTTSPEELN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 179 AKVFFP--LEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSF 256
Cdd:cd15168 161 DYVIYSmvLTGLGFLLPLLIILACYGLIVRALIRKLGEGVTSALRRKSIRLVIIVLALFAVCFLPFHVTRTINLAARLLS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 33695107 257 IVE-CRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRM 297
Cdd:cd15168 241 GTAsCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFRR 282
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
52-296 1.59e-25

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 102.91  E-value: 1.59e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  52 RWPDYAATSIYMINLAVFDLLLVLSLPFKMV--LSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLL 128
Cdd:cd15162  28 RTKKKAPAVIYMANLAIADLLLVIWLPFKIAyhIHGNNWIFGEaLCRLVTVAFYGNMYCSILLLTCISIDRYLAIVHPMG 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 129 VSHLRSPRKIFGICCTIWVLVWTGSIPIYS-----FHGKVEKYMCFHNMSDDTWSA---KVFFPLEVFGFLLPMGIMGFC 200
Cdd:cd15162 108 HRRLRARRYALGTCLAIWLLALLVTLPLYLvkqtiFLPALDITTCHDVLPEQLLVGdwfYYFLSLAIVGFLIPFILTASC 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 201 CSRSIHILLGRRDHTQDwVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSfivecRAKQSISFFLQLSMCFSNVN 280
Cdd:cd15162 188 YVATIRTLAALEDENSE-KKKKRAIKLAATVLAIFIICFAPSNLLLLAHYSLISS-----SGTGHLYFAYLLALCLSTLN 261
                       250
                ....*....|....*.
gi 33695107 281 CCLDVFCYYFVIKEFR 296
Cdd:cd15162 262 SCIDPFIYYFVSKEFR 277
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
60-296 1.95e-25

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 102.85  E-value: 1.95e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLLVLSLPFKMVLSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15160  36 GVYLLNLSLSDLLYILTLPLWIDYTANHHNWtfgPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRR 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIY----SFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILlgRR 212
Cdd:cd15160 116 FALKVSASIWVLELGTHSVFLghdeLFRDEPNHTLCYEKYPMEGWQASYNYARFLVGFLIPLSLILFFYRRVLRAV--RQ 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 213 DHTQDwVQQKACIYSIAASL-AVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFV 291
Cdd:cd15160 194 SPSLE-REEKRKIIGLLLSIvVIFLLCFLPYHVVLLVRSVIELVQNGLCGFEKRVFTAYQISLCLTSLNCVADPILYIFV 272

                ....*
gi 33695107 292 IKEFR 296
Cdd:cd15160 273 TEDVR 277
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
59-301 2.86e-24

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 100.62  E-value: 2.86e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107   59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQ--SPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:PHA03087  74 MDIYLLNLAVSDLLFVMTLPFQIYYYILFqwSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVK 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  137 KIFGICCTIWVLVWTGSIPIYSF------HGKVEKYMcFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLG 210
Cdd:PHA03087 154 YGYIVSLVIWIISIIETTPILFVyttkkdHETLICCM-FYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKILITLKG 232
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  211 RRDHTQDwvqqKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYF 290
Cdd:PHA03087 233 INKSKKN----KKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAF 308
                        250
                 ....*....|.
gi 33695107  291 VIKEFRMNIRA 301
Cdd:PHA03087 309 VSEFFNKHKKK 319
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
59-296 3.12e-24

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 99.44  E-value: 3.12e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15372  34 STIFLINLAVADLLLILVLPFKISYHFLGNNWPfgeGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSR 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPI------YSFHgKVEKYMCFHNM---SDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIH 206
Cdd:cd15372 114 RFALCMCTAIWLIAAALTLPLtlqrqsYPLE-RLNITLCHDVLpldEQDTYLFYYFACLAVLGFLLPLVVILFCYGSVLH 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 207 ILL--GRRDHTQDWVqqkaciysIAASLAVFVVSFLPVHLGFFLQFlvrNSFIVECRAKQSISFFlqLSMCFSNVNCCLD 284
Cdd:cd15372 193 TLLrsGQRYGHAMKL--------TVLVLVSFVLCFTPSNLLLLLHY---SDPTLDDGGNLYIVYM--VSLAISTLNSCVD 259
                       250
                ....*....|..
gi 33695107 285 VFCYYFVIKEFR 296
Cdd:cd15372 260 PFIYYYVSEEFR 271
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
59-296 3.91e-24

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 99.01  E-value: 3.91e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMV--LSQVQSPFPSL-CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15161  35 SNVFLMHLAVADLSYVLILPMRLVyhLSGNHWPFGEVpCRLAGFLFYLNMYASLYFLACISVDRFLAIVHPVKSMKIRKP 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSFHGKVE---KYMCFHnMSDDTWSAKVFFPLEVfGFLLPMGIMGFCcsrsiHILLGRR 212
Cdd:cd15161 115 LYAHVVCGFLWVIVTVAMAPLLVSPQTVEvnnTTVCLQ-LYREKASRGALVSLAV-AFTIPFVTTVTC-----YLLIIRS 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 213 DHTQDWVQQKA---CIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYY 289
Cdd:cd15161 188 LRTGKREEKPLkdkAIKMIILVLTIFLICFVPYHISRYIYILSHNGAGASCSSRRGLALANRITSCLTCLNGALDPVMYF 267

                ....*..
gi 33695107 290 FVIKEFR 296
Cdd:cd15161 268 FVAEKFR 274
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
61-296 1.65e-23

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 97.56  E-value: 1.65e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQS-PFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSpRKI 138
Cdd:cd15153  37 IFMINLAVADLAHVLSLPLRIHYYIQHTwPFGRfLCLLCFYLKYLNMYASICFLTCISIQRCFFLLHPFKARDWKR-RYD 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 139 FGICCTIWVLVWTGSIP---IYSFHGKVEKYMCFHNMSDDTWSAKVFFPL----EVFGFLLPMGIMGFCCSRSIHILLGR 211
Cdd:cd15153 116 VGISAAVWIVVGLACLPfplLRSKSLSNNNRSCFADLGMKKLNFGAAIAMmtvaELFGFVIPLFIIAWCTWKTENSLRQR 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 212 RDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFV 291
Cdd:cd15153 196 NKQQQSTSEKQKALRMVRMCAAVFFICFAPYHINFLFYLMVSESIITNCEVSQVILQFHPISLCLASLNCCLDPILYYFM 275

                ....*
gi 33695107 292 IKEFR 296
Cdd:cd15153 276 TSEFQ 280
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
61-296 3.97e-23

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 96.38  E-value: 3.97e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15368  37 IFMINLSLTDLMLACFLPFQIVYHIQRNHWifgKPLCNVVTVLFYANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRY 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPI------YSFHgKVEKYMCFH----NMSDDTWSAKVF-FPLEVFGFLLPMGIMGFCCSRSIH 206
Cdd:cd15368 117 AVAACIGMWLLVLTALSPLertdltYYVK-ELNITTCFDvlkwTMLPNIAAWAAFlFTLFILLFLIPFIITVYCYVLIIL 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 207 ILLGRRDHTQDwVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFivecraKQSISFFLQLSMCFSNVNCCLDVF 286
Cdd:cd15368 196 KLVQTSERYGR-EQKRRAIYLALIVLLVFITCFAPNNFILLAHMVSRLFY------GKSLYHAYKLTLSLSCLNSCLDPF 268
                       250
                ....*....|
gi 33695107 287 CYYFVIKEFR 296
Cdd:cd15368 269 IYYFASKEFR 278
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
58-296 6.02e-23

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 96.00  E-value: 6.02e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKMV--LSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15968  34 RTAIYMVNLALADLLYALSLPLLIYnyAMRDRWLFGDfMCRLVRFLFYFNLYGSILFLTCISVHRYLGICHPMRPWHKET 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPIYSFH---GKVEKYMCFHNMSDDTWSAKVFF--PLEVFGFLLPMGIMGFCCSRSIHILL 209
Cdd:cd15968 114 RRAAWLTCVLVWILVFAQTLPILIFArtgIIRNRTVCYDLAPPALFPHYVPYgmALTVSGFLLPFSIILWCYCLVVRTLC 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 gRRDHTQDWVQQKA---CIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVF 286
Cdd:cd15968 194 -RTLGPAEPPAQARrrkSIRTIVTVTLLFALCFLPFHITRTIYLAVRVTPGVPCHVLEAVAACYKITRPLASANSVLNPL 272
                       250
                ....*....|
gi 33695107 287 CYYFVIKEFR 296
Cdd:cd15968 273 LYFLTKKKFG 282
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
58-290 9.91e-23

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 95.43  E-value: 9.91e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLL-LVLSLPFKMVLSQVQSPF--PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd00637  32 VTNYFILNLAVADLLvGLLVIPFSLVSLLLGRWWfgDALCKLLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFT 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPIYSFHGKVE---KYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGR 211
Cdd:cd00637 112 RRRAKLLIALIWLLSLLLALPPLLGWGVYDyggYCCCCLCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRH 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 212 RDHTQDWVQQKAC----------IYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVecrakqsISFFLQLSMCFSNVNC 281
Cdd:cd00637 192 RRRIRSSSSNSSRrrrrrrerkvTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPSPL-------PRILYFLALLLAYLNS 264

                ....*....
gi 33695107 282 CLDVFCYYF 290
Cdd:cd00637 265 AINPIIYAF 273
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
59-298 2.11e-22

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 94.26  E-value: 2.11e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPL-LVSHLRSPR 136
Cdd:cd15178  35 TDVYLLHLAIADLLFALTLPFWAVSVVKGWIFGTfMCKLVSLLQEANFYSGILLLACISVDRYLAIVHATrALTQKRHLV 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KifGICCTIWVLVWTGSIPIYSFHG-----KVEKYMCFHNM---SDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHIL 208
Cdd:cd15178 115 K--FVCAGVWLLSLLLSLPALLNRDafkppNSGRTVCYENLgneSADKWRVVLRILRHTLGFLLPLVVMLFCYGFTIKTL 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 209 LgrrdHTQDWVQQKAcIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVE-CRAKQSISFFLQLSMCFSNVNCCLDVFC 287
Cdd:cd15178 193 L----QTRSFQKHRA-MRVIFAVVLAFLLCWLPYNVTVLIDTLMRTKLITEtCELRNHVDVALYVTQILGFLHSCINPVL 267
                       250
                ....*....|.
gi 33695107 288 YYFVIKEFRMN 298
Cdd:cd15178 268 YAFIGQKFRNN 278
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
49-297 3.05e-22

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 93.99  E-value: 3.05e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  49 LKNRWPdYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPL 127
Cdd:cd15180  26 LQKRRN-LSVTDTFILHLALADILLLVTLPFWAVQAVHGWIFGTgLCKLAGAVFKINFYCGIFLLACISFDRYLSIVHAV 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 128 LVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKY-----MCFHN--MSDDTWSAKVFFPLEVFGFLLPMGIMGFC 200
Cdd:cd15180 105 QMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATKDPrqnktECVHNfpQSDTYWWLALRLLYHIVGFLLPLAVMVYC 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 201 CSrsiHILLGRRDHTQDWVQQKAcIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFI-VECRAKQSISFFLQLSMCFSNV 279
Cdd:cd15180 185 YT---SILLRLLRSSQGFQKQRA-IRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVLdRNCGTESRLDIALSVTSSLGYF 260
                       250
                ....*....|....*...
gi 33695107 280 NCCLDVFCYYFVIKEFRM 297
Cdd:cd15180 261 HCCLNPLLYAFVGVKFRR 278
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
57-296 1.02e-21

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 92.55  E-value: 1.02e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  57 AATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15187  33 SMTDVYLLNLAASDLLFVFSLPFQAYYLLDQWVFgNAMCKIVSGAYYIGFYSSMFFITLMSIDRYLAIVHAVYALKVRTA 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSFHGKVE-----KYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILlg 210
Cdd:cd15187 113 SHGTILSLALWLVAILASVPLLVFYQVASedgrlQCIPFYPGQGNSWKVFTNFEVNILGLLIPFSILIFCYHNILRNL-- 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 211 RRDHTQDWVQqkaciySIAASLAVFVVSFL---PVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFC 287
Cdd:cd15187 191 RRCHNQNKTK------AIKLVFIVVIVFFLfwtPFNVVLFLDSLHSLHIIDGCQNSQRLTLALHLTETISFTHCCLNPVI 264

                ....*....
gi 33695107 288 YYFVIKEFR 296
Cdd:cd15187 265 YAFVGEKFK 273
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
61-296 2.50e-21

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 91.76  E-value: 2.50e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPF--KMVLSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15189  37 IYLGNLAAADLVFVSGLPFwaMNILNQFNWPFgELLCRVVNGVIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRY 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPI--------YSFHGKVEkymCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILL 209
Cdd:cd15189 117 AKLICVLIWVVGLLLSIPTfllrkikaIPDLNITA---CVLLYPHEAWHFAHIVLLNIVGFLLPLLVITFCNYNILQALR 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 GRRDHT--QDWVQQKACIYSIAASLAvFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFC 287
Cdd:cd15189 194 TREESTrcEDRNDSKATALVLAVTLL-FLVCWGPYHFFTFLDFLFDVGVLDECFWEHFIDIGLQLAVFLAFSNSCLNPVL 272

                ....*....
gi 33695107 288 YYFVIKEFR 296
Cdd:cd15189 273 YVFVGRYFR 281
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
43-296 4.26e-21

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 91.02  E-value: 4.26e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  43 HGFSTF-LKNRWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS---LCTLVECLYFVSMYGSVFTICFISMD 118
Cdd:cd15921  18 NSISVYvFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFgdiACRIILYVLYVNMYSSIYFLTALSVF 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 119 RFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSF----------------HGKVEKYMCFHNMSddtwsakvf 182
Cdd:cd15921  98 RYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAkskqhdegstrclelaHDAVDKLLLINYVT--------- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 183 fplEVFGFLLPMGIMGFCCSRSIHILL-GRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECR 261
Cdd:cd15921 169 ---LPVGFVVPFMTVIFCYIFIIKNLLkPSPALGRTRPSRRKACALIIISLGIFLVCFLPYHIVRTIHLITERQIKESCG 245
                       250       260       270
                ....*....|....*....|....*....|....*
gi 33695107 262 AKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15921 246 YILRVRKAAVITLCLAASNSCFDPLLYFFVGENFR 280
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
60-299 1.10e-20

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 89.81  E-value: 1.10e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLLVLSLPFKMVLSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLvSHLRSPR 136
Cdd:cd15191  36 SIYIFNLAVADLLFLATLPLWATYYSYGYNWlfgSVMCKICGSLLTLNLFASIFFITCMSVDRYLAVVYPLR-SQRRRSW 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSFH--------GKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHIL 208
Cdd:cd15191 115 QARLVCLLVWVLACLSSLPTFYFRdtyyieelGVNACIMAFPNEKYAQWSAGLALMKNTLGFLIPLIVIATCYFGIGRHL 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 209 LGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCY 288
Cdd:cd15191 195 LKTKGFGKNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDALARMGVINNCWVITVIDKALPFAICLGFSNSCINPFLY 274
                       250
                ....*....|.
gi 33695107 289 YFVIKEFRMNI 299
Cdd:cd15191 275 CFVGNHFREKL 285
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
61-296 1.16e-20

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 89.86  E-value: 1.16e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPF--KMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15380  37 IYLANLAASDLVFVLGLPFwaENIRNQFNWPFGNfLCRVISGVIKANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQ 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHG-----KVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCcsrSIHILLGRR 212
Cdd:cd15380 117 AQVICLLIWVFGGLLSIPTFLFRSvkhvpDLNISACILLFPHEAWHFARRVELNIVGFLLPLAAIVFF---NFHIIASLR 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 213 DHTQdwVQQKAC--------IYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLD 284
Cdd:cd15380 194 ERTE--ESRKRCgglkdtkaTRLILTLVLMFLVCWTPYHFFAFLDFLFQVEVIQGCFWEEFIDLGLQLANFFAFANSCLN 271
                       250
                ....*....|..
gi 33695107 285 VFCYYFVIKEFR 296
Cdd:cd15380 272 PVIYVFAGKLFR 283
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
61-290 2.82e-20

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 88.67  E-value: 2.82e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15369  37 IYMLNLACADLLFVLLLPFKIAYHFSGNDWlfgEAMCRVVTAAFYCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRR 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIY----SFHGKVEKYMCFHNMSDDT---WSAKVFFP-LEVFGFLLPMGIMGFCCSRSIHILL 209
Cdd:cd15369 117 ASFTCAAIWLLSIAGVVPLLlseqTIQIPDLGITTCHDVLNEQllmGYYVYYFSiFSCLFFFVPLIITTVCYVSIIRCLS 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 GRRDHTQDWVQQKACIYSIAAsLAVFVVSFLPVHLGFFLQFLvrnsFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYY 289
Cdd:cd15369 197 SSSDVANSSKKTRALFMAVAV-FCVFVICFGPTNVLLLAHYV----RFAYTSTNDASYFAYLLCVCVGSISCCLDPLIYY 271

                .
gi 33695107 290 F 290
Cdd:cd15369 272 Y 272
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
47-296 6.61e-20

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 87.50  E-value: 6.61e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  47 TFLKNRWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRY 125
Cdd:cd15181  23 TILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAGWVFGTfLCKLVGAIHKLNFYCSSLLLACISVDRYLAIVH 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 126 PLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHgKVEKYM-------CFHN--MSDDTWSAKVFFPLEVFGFLLPMGI 196
Cdd:cd15181 103 AIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFL-EVETSTnanrtscSFHQygIHESNWWLTSRFLYHVVGFFLPLLI 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 197 MGFCCSRSIHILlgrRDHTQDWVQQKACIYSIAASLaVFVVSFLPVHLGFFLQFLVR-NSFIVECRAKQSISFFLQLSMC 275
Cdd:cd15181 182 MGYCYATIVVTL---CQSSRRLQKQKAIRVAILVTL-VFCLCWLPYNIVIFLDTLDDlKAVVKNCKLNDLLDAAITVTES 257
                       250       260
                ....*....|....*....|.
gi 33695107 276 FSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15181 258 LGFSHCCLNPILYAFIGVKFR 278
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
59-296 9.48e-20

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 87.13  E-value: 9.48e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15175  35 TDIYLLNLALADILFLLTLPFWAASAAKKWVFGEeMCKAVYCLYKMSFFSGMLLLMCISIDRYFAIVQAASAHRHRSRAV 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFG--ICCTIWVLVWTGSIPIYSFHGKVEKY---MCFHNMSD-DTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGR 211
Cdd:cd15175 115 FISkvSSLGVWVLAFILSIPELLYSGVNNNDgngTCSIFTNNkQTLSVKIQISQMVLGFLVPLVVMSFCYSVIIKTLLQA 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 212 RDhtqdwVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVR-NSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYF 290
Cdd:cd15175 195 RN-----FEKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSfKGNTTDCDYSKNLDFALDVTYSLACFRCCLNPFLYAF 269

                ....*.
gi 33695107 291 VIKEFR 296
Cdd:cd15175 270 IGVKFR 275
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
24-300 1.13e-19

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 86.93  E-value: 1.13e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  24 FAVHIPTFVLGLLLNLLAIHGFSTFLKNRwpdYAATSIYMINLAVFDLLLVLSLPFKMV--LSQVQSPFPS-LCTLVECL 100
Cdd:cd15170   4 LAVYIITFLIGLPANLLAFYTFIRKVRRK---PTPIDILLLNLTVSDLIFLLFLPFKMAeaASGMIWPLPYfLCPLSSFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 101 YFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIY--SFHGKVE------KYMCFHNM 172
Cdd:cd15170  81 FFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFSHCSIVYivEYHIDSEntsvtnNSRCYDNF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 173 SDDtwSAKVFFP--LEVFG--FLLPMGIMGFCCSRSIHILLgRRDHTQDWVQQKAcIYSIAASLAVFVVSFLPVHLGFFL 248
Cdd:cd15170 161 TPE--QLKILLPvrLELFLvlFCIPFLITCFCYINFIRILS-SLPHISRQRKQRA-IGLAVATLLNFIVCFAPYNISHVV 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 33695107 249 QFLVRNSfiVECRAKqsisfflqlSMCFSNVNCCLDVFCYYFVIKEFRMNIR 300
Cdd:cd15170 237 GFIQRKS--PEWRMY---------ALLLSTLNACLDPIIFYFSSSAVRRAFK 277
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
60-299 2.44e-19

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 86.01  E-value: 2.44e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLLVLSLPFKMVLSQVQSPFpSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIF 139
Cdd:cd15920  36 SVYMRNLALADLLLVLCLPFRVAYQNTAGPL-SFCKIVGAFFYLNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSS 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 140 GICCTIWVLVWTGSIP--IYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCC--SRSIHILLGRRDHT 215
Cdd:cd15920 115 AASGGVWLLLLACMIPflFESRNEGPCDNKCFHFRSKGLTAGGINLTAVVIFYILSLLFLYFYAkiSHKLYKVSLGNAQQ 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 216 QDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEF 295
Cdd:cd15920 195 QIKKASKRAIIKTFIVLAIFIVCFVPYHIVRVPYVLAQIDVISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSF 274

                ....
gi 33695107 296 RMNI 299
Cdd:cd15920 275 RRAV 278
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
59-297 6.85e-19

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 84.84  E-value: 6.85e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15188  36 TEVYLLNLAVSDLLFLVTLPFWAMYVAWHWVFGSfLCKFVSTLYTINFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRK 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSF----HGKVEKYMCFHNMSDDTWSAKVFFPLE--VFGFLLPMGIMGFCCSRSIHILLGR 211
Cdd:cd15188 116 SLLVLVAVWVLSIALSVPDMVFvqthHTNNGVWVCHADYGGHHTIWKLVFQFQqnLLGFLFPLLAMVFFYSRIACVLTRL 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 212 RDhtqdwVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFV 291
Cdd:cd15188 196 RP-----PGQGRALRFVAALVVVFFVLWFPYNLTLFLHSLQDLHVIGNCERSRHLDYALQVTESLAFVHCCLNPLLYAFV 270

                ....*.
gi 33695107 292 IKEFRM 297
Cdd:cd15188 271 SKRFRL 276
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
59-299 7.08e-19

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 84.80  E-value: 7.08e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15174  35 TDVYLLNLAIADLLFLCTLPFWATAASSGWVFGTfLCKVVNSMYKINFYSCMLLLTCISVDRYIAIVQATKAHNSKNKRL 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFG--ICCTIWVLVWTGSIPIYSFHGKVEKY------MCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILL 209
Cdd:cd15174 115 LYSklVCFFVWLLSTILSLPEILFSQSKEEEsvttctMVYPSNESNRFKVAVLALKVTVGFFLPFVVMVICYTLIIHTLL 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 GRRDhtqdwVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFL-VRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCY 288
Cdd:cd15174 195 QAKR-----FQKHKALKVIIAVVTVFVLSQLPYNSILLIKTInAYNITITDCATSQNLDIAGQVTQSIAFLHSCLNPFLY 269
                       250
                ....*....|.
gi 33695107 289 YFVIKEFRMNI 299
Cdd:cd15174 270 VFVGVRFRKDL 280
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
59-296 7.96e-19

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 84.50  E-value: 7.96e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPF-KMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15186  35 TDIYLLNLALSDLLFVATLPFwTHYLINEWGLHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQH 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHGKVEKyMCFHNMSD---DTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDH 214
Cdd:cd15186 115 GVTISLGVWAAAILVAVPQFMFTKMKEN-ECLGDYPEvlqEIWPVLRNVELNFLGFLLPLLIMSYCYFRIIQTLFSCKNH 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 215 tqdwvQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKE 294
Cdd:cd15186 194 -----KKARAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPSCDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEK 268

                ..
gi 33695107 295 FR 296
Cdd:cd15186 269 FR 270
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
59-296 1.22e-18

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 84.27  E-value: 1.22e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLL-LVLSLPF---KMVLSQvqSPFP-SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15096  35 TNILILNLAVADLLfVVFCVPFtatDYVLPT--WPFGdVWCKIVQYLVYVTAYASVYTLVLMSLDRYLAVVHPITSMSIR 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIPIYSFHGKV-------EKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFccsrsIH 206
Cdd:cd15096 113 TERNTLIAIVGIWIVILVANIPVLFLHGVVsygfsseAYSYCTFLTEVGTAAQTFFTSFFLFSYLIPLTLICV-----LY 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 207 ILLGRRdhtqDWVQQKACIYSIAAS--------------LAVFVVSFLPVHLGFFLQFLVRNSfivECRAKQSISFflqL 272
Cdd:cd15096 188 MLMLRR----LRRQKSPGGRRSAESqrgkrrvtrlvvvvVVVFAICWLPIHIILLLKYYGVLP---ETVLYVVIQI---L 257
                       250       260
                ....*....|....*....|....
gi 33695107 273 SMCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15096 258 SNCLAYGNSCVNPILYAFLSQNFR 281
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
52-299 2.71e-18

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 82.90  E-value: 2.71e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  52 RWPDYAATSIYMINLAVFDLLLVLSLPFKM---VLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLL 128
Cdd:cd14988  28 RWGSKNLVNLYILNMAIADLGVVLTLPVWMlevMLDYTWLWGSFLCKFTHYFYFANMYSSIFFLTCLSVDRYLTLTSSSP 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 129 VSHLRSPRKIFGICCTIWVL-------------VWTGSIPIYSFHGKVEKYmcfhnmsdDTWSAKVFFPLEVFGFLLPMG 195
Cdd:cd14988 108 FWQQHQHRIRRALCAGIWVLsaiiplpevvhmqLLDGVEPMCLFLAPFETY--------DEWALAVSLLTLIIGFLIPFS 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 196 IMGFCcsrsiHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMC 275
Cdd:cd14988 180 IIAVF-----NVLTARYIRTAGRPESRRHCLLIYAYILVFVVCWLPYHVTLLLLTLHGSHISLHCNLVHFLYFFYDVIDC 254
                       250       260
                ....*....|....*....|....
gi 33695107 276 FSNVNCCLDVFCYYFVIKEFRMNI 299
Cdd:cd14988 255 FSLLHCVANPILYNFLSKSFRGKL 278
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
59-297 2.77e-18

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 82.61  E-value: 2.77e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLL-VLSLPFKMV--LSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd14967  34 TNYFIVSLAVADLLVaLLVMPFSAVytLLGYWPFGPVLCRFWIALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTK 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWV---LVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAKVFFpleVFGFLLPMGIMGFCCSRSIHILlgRR 212
Cdd:cd14967 114 KRALIMIAAVWVyslLISLPPLVGWRDETQPSVVDCECEFTPNKIYVLVSS---VISFFIPLLIMIVLYARIFRVA--RR 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 213 DHtqdwvqqKAciysiAASLAVFVVSFLPVHLGFFLQFLVrNSFIVECRAKQSISFFlqlSMCFSNVNCCLDVFCYYFVI 292
Cdd:cd14967 189 EL-------KA-----AKTLAIIVGAFLLCWLPFFIIYLV-SAFCPPDCVPPILYAV---FFWLGYLNSALNPIIYALFN 252

                ....*
gi 33695107 293 KEFRM 297
Cdd:cd14967 253 RDFRR 257
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
59-299 3.83e-18

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 82.52  E-value: 3.83e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15177  35 TDVYLLNLALADLLLLLTLPFAAAETLQGWIFGNaMCKLIQGLYAINFYSGFLFLTCISVDRYVVIVRATSAHRLRPKTL 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGI--CCTIWVLVWTGSIPIYSFhGKVEKY-------MCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHIL 208
Cdd:cd15177 115 FYSVltSLIVWLLSILFALPQLIY-SRVENRselsscrMIFPEVVSRTVKGATALTQVVLGFAIPLIVMAVCYAAIGRTL 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 209 LgrrdHTQDWVQQKAcIYSIAASLAVFVVSFLPVHLGFFLQFL-VRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFC 287
Cdd:cd15177 194 L----AARGWERHRA-LRVIAALVVAFVLFQLPYSVVLLLDTAdLLATLELSCSQSKRKDIALLVTSGLAYVRCCLNPLL 268
                       250
                ....*....|..
gi 33695107 288 YYFVIKEFRMNI 299
Cdd:cd15177 269 YAFVGVRFRRDI 280
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
58-296 5.67e-18

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 82.50  E-value: 5.67e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKMVLSQVQS--PFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15190  45 SADTFIANLALADLTFVVTLPLWAVYTALGYhwPFGSfLCKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRS 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPIYSF-----HGKVEKYMCFHNMS-------DDTWSAKVFFPLEVFGFLLPMGIMGFC-C 201
Cdd:cd15190 125 RTSGIVALGVIWLLAALLALPALILrttsdLEGTNKVICDMDYSgvvsnesEWAWIAGLGLSSTVLGFLLPFLIMLTCyF 204
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 202 SRSIHILLGRRDHTQDWVQQKACIYSIAASL-AVFVVSFLPVHLGFFLQFLVRNSFI-VECRAKQSISFFLQLSMCFSNV 279
Cdd:cd15190 205 FIGRTVARHFSKLRRKEDKKKRRLLKIIITLvVTFALCWLPFHLVKTLYALMYLGILpFSCGFDLFLMNAHPYATCLAYV 284
                       250
                ....*....|....*..
gi 33695107 280 NCCLDVFCYYFVIKEFR 296
Cdd:cd15190 285 NSCLNPFLYAFFDPRFR 301
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
21-290 7.23e-18

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 81.71  E-value: 7.23e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  21 TLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRwpdYAATSIYMINLAVFDLLLVLSLPFKMV--LSQVQSPFPSLCTLVE 98
Cdd:cd14983   1 QLSLMVYVLTILLGLPSNLLALYAFVNRARLR---LTPNVIYMINLCLSDLVFILSLPIKIVeaLSSAWTLPAVLCPLYN 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  99 CLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWT------------GSIPIYSFHGKveKY 166
Cdd:cd14983  78 LAHFSTLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVIFhvtlvfiletsgGTLDINTPVGN--SS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 167 MCFHNMSDDTWS--AKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQdwvQQKACIYSIAASLAVFVVSFLPVHL 244
Cdd:cd14983 156 TCYENFTPEQLAllAPVRLELSLVLFFLPLAITAFCYVRCIRILVRSRLHER---RKRRAVRVAVSTLLTFVVCFGPYNI 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 33695107 245 GFFLQFLVRNSfiVECRakqsisfflQLSMCFSNVNCCLDVFCYYF 290
Cdd:cd14983 233 SHVVGFVRHES--VWWR---------KLALLTSTCNAFLDPLIFYF 267
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
61-296 7.87e-18

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 81.72  E-value: 7.87e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMV--LSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15158  37 IYMLNLAVSDLLCVCTLPLRVVyyVHKGQWLFGDfLCRISSYALYVNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKK 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIY---SFHGKVEKYMCFHNMSDDTWSAKV----FFPLeVFGFLLPMGIMGFCCSRSIHILLG 210
Cdd:cd15158 117 ARIVCVGIWIFVTLTSSPFLmsgSHDTETNKTKCFEPPQSNQQLTKLlvlnYISL-VVGFIIPFLVILICYAMIIRTLLK 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 211 R--RDHTQDWVQQKAcIYSIAASLAVFVVSFLPVHL--GFFLQFLVRNSfiVECRAKQSISFFLQLSMCFSNVNCCLDVF 286
Cdd:cd15158 196 NtmKARKQQSSRKKA-IRMIIIVLLAFLVSFMPYHIqrTIHLHFLSRKD--STCEEVLYMQKSVVITLCLAAANCCFDPL 272
                       250
                ....*....|
gi 33695107 287 CYYFVIKEFR 296
Cdd:cd15158 273 LYFFSGENFR 282
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
56-289 1.02e-17

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 81.73  E-value: 1.02e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  56 YAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS---LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHL 132
Cdd:cd16001  32 WTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFgdfLCKLVRFLFYTNLYGSILFLTCISVHRFLGVCYPIRSLAY 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 133 RSPRKIFGICCTIWVLVWTGSIP--IYSFHGKVE-KYMCFHNMSDDTWSAkvFFP----LEVFGFLLPMGIMGFCCSRSI 205
Cdd:cd16001 112 RTRRLAVIGSAATWILVVLQLLPtlVYARTGSINnRTVCYDLTSPDNFGN--YFPygmvLTVTGFLIPFLIILLCYCLMI 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 206 HILLGRRDHTQdwVQQKACIYSIAASLAV---FVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCC 282
Cdd:cd16001 190 KSLIRSEEAAG--VGKAARAKSIRTILLVcglFALCFVPFHITRTIYLFVRVYLVQDCPLLQFVSLAYKIWRPLVSFNSC 267

                ....*..
gi 33695107 283 LDVFCYY 289
Cdd:cd16001 268 INPLLYF 274
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
61-299 1.92e-17

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 80.59  E-value: 1.92e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLS---QVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15365  37 VYLFNLSLSDLLYIVILPLWIDYLwngDNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRT 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIY----SFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFcCSRSIHILLGRRD 213
Cdd:cd15365 117 ALSVSVAIWLLEICFNAVILtwedSFHESSSHTLCYDKFPLEDWQARLNLFRICLGYLLPLLIILF-CYWKIYQAVRSNQ 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 214 HTQDwvQQKACIYSIAASLAV-FVVSFLPVHLGFFLQFLVRNSfivECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVI 292
Cdd:cd15365 196 ATED--QEKKKIFKLLLLITVtFVICFTPYHVVLLIRSIVEPC---DCRNAKWLYTLYKITVALTSLNCIADPFLYCFVT 270

                ....*..
gi 33695107 293 KEFRMNI 299
Cdd:cd15365 271 ESGRADI 277
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
54-296 2.57e-17

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 80.20  E-value: 2.57e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  54 PDYAATSIYMINLAVFDLLLVL-SLPFKMVLSQVQS-PFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVS 130
Cdd:cd14971  30 PMRSTTNLFILNLAVADLTFLLfCVPFTATIYPLPGwVFGDfMCKFVHYFQQVSMHASIFTLVAMSLDRFLAVVYPLRSL 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 131 HLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAK-----VFFPLEVFGFLLPMGIMGFCCSRSI 205
Cdd:cd14971 110 HIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVCSEAWPSRahrraFALCTFLFGYLLPLLLICVCYAAML 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 206 HIL----LGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLgfflqFLVRNSFIVECRAKQSISFFLqLSMCFSNVNC 281
Cdd:cd14971 190 RHLwrvaVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHA-----ILLLVALGPFPLTYATYALRI-WAHCLAYSNS 263
                       250
                ....*....|....*
gi 33695107 282 CLDVFCYYFVIKEFR 296
Cdd:cd14971 264 AVNPVLYAFLSEHFR 278
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
59-296 3.08e-17

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 80.18  E-value: 3.08e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSL-CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15172  35 TDVYLLNMAIADILFVLTLPFWAVYEAHQWIFGNFsCKLLRGIYAINFYSGMLLLACISVDRYIAIVQATKSFRLRSRTL 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFG--ICCTIWVLVWTGSIPIYSF-----HGKVEKYMCFHNMsDDTWSAKVFFPLEV-----FGFLLPMGIMGFCCSRSI 205
Cdd:cd15172 115 AYSklICAAVWLLAILISLPTFIFsevydFGLEEQYVCEPKY-PKNSTAIMWKLLVLslqvsLGFFIPLLVMIFCYSFII 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 206 HILLGRRDhtqdwVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSfIVECRAKQSISFFLQLSMCFSNVNCCLDV 285
Cdd:cd15172 194 KTLLQAQN-----SQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEAINLGE-QQSCSSEKAVAYAKTITECLAFFHCCLNP 267
                       250
                ....*....|.
gi 33695107 286 FCYYFVIKEFR 296
Cdd:cd15172 268 VLYAFIGVKFR 278
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
61-296 3.30e-17

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 80.14  E-value: 3.30e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15157  37 IFMLNLAVSDLMFVSTLPFRADYYLMGSHWvfgDIACRIMSYSLYVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKY 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIY----SFHGKVEKYMCFHNMSDDTWSAKVFFPLeVFGFLLPMGIMGFCCSRSIHILLGRR- 212
Cdd:cd15157 117 ARILCAVIWIFVMAASSPLLskgtSKYNSQTKCLDLHPSKIDKLLILNYIVL-VVGFILPFCTLSICYILIIKALLKPRv 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 213 DHTQDWVQQKACIYSIAASLAVFVVSFLPVHlgfflqfLVRNSFIVECRAKQSISFF---LQLSMCFSNVNCCLDVFCYY 289
Cdd:cd15157 196 PQSKLRVSHKKALLTIIITLILFLLCFLPYH-------ILRTVHLMQWSEGQCNLRLhkaVVITLCLAAANSCLDPLLYY 268

                ....*..
gi 33695107 290 FVIKEFR 296
Cdd:cd15157 269 FAGENFK 275
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
61-296 3.95e-17

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 80.18  E-value: 3.95e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQSP--FPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15147  39 IFMVNLTIADLLFLITLPFWIVYYHNEGNwiLPKfLCNVAGCLFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKR 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHG-KVEKYM------CFHNMSDDTWSAKVFFPLE-VFGFLLPMGIMGFCCSRSIHILL 209
Cdd:cd15147 119 GIIISVAIWVIIVASASYFLFMDStNTVKIDsgnftrCFEGYEKDNSKPVLIIHFIiIGLFFLVFLLILVCNLVIARTLL 198
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 -----GRRDHTqdwVQQKAcIYSIAASLAVFVVSFLP---VHLGFFLQFLvRNSFIVECRAKQSISFFLQLSMCFSNVNC 281
Cdd:cd15147 199 sqpvqGQRNAG---VKRRA-LWMVCTVLAVFVICFVPhhvVQGPWTLAVL-QQWRYWDCQFRQALNDAHQITLCLMSTNC 273
                       250
                ....*....|....*
gi 33695107 282 CLDVFCYYFVIKEFR 296
Cdd:cd15147 274 VLDPVIYCFLTKKFR 288
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
58-299 4.94e-17

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 79.65  E-value: 4.94e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKMVLSQVQS-PFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd14970  34 VTNIYILNLAVADELFLLGLPFLATSYLLGYwPFGEvMCKIVLSVDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTP 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSFHG----KVEKYMCFHNMSDDTWSAKVFFPLEVF--GFLLPMGIMGFCCSRSIHILL 209
Cdd:cd14970 114 RKAKLVSLCVWALSLVLGLPVIIFARtlqeEGGTISCNLQWPDPPDYWGRVFTIYTFvlGFAVPLLVITVCYSLIIRRLR 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 GRRDHTQDWVQQKACIYS-----IAASLAVFVVSFLPVHLGFFLQFLVRnsfIVECRAKQSISFFLqlsMCFSNVNCCLD 284
Cdd:cd14970 194 SSRNLSTSGAREKRRARRkvtrlVLVVVAVFVVCWLPFHVFQIVRLLID---PPETLTVVGVFLFC---IALSYANSCLN 267
                       250
                ....*....|....*
gi 33695107 285 VFCYYFVIKEFRMNI 299
Cdd:cd14970 268 PILYAFLDENFRKSF 282
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
58-296 6.48e-17

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 79.57  E-value: 6.48e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVL-SLPFKMVlSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd14993  34 VTNYFLVNLAVADLLVSLfCMPLTLL-ENVYRPWvfgEVLCKAVPYLQGVSVSASVLTLVAISIDRYLAICYPLKARRVS 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIP----------IYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCS- 202
Cdd:cd14993 113 TKRRARIIIVAIWVIAIIIMLPllvvyeleeiISSEPGTITIYICTEDWPSPELRKAYNVALFVVLYVLPLLIISVAYSl 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 203 -------RSIHILLGRRDHTQDWVQQKACIYSIAASLAV---FVVSFLPVH-LGFFLQFLVRNSFIVECRAKQSISFFLq 271
Cdd:cd14993 193 igrrlwrRKPPGDRGSANSTSSRRILRSKKKVARMLIVVvvlFALSWLPYYvLSILLDFGPLSSEESDENFLLILPFAQ- 271
                       250       260
                ....*....|....*....|....*
gi 33695107 272 lsmCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd14993 272 ---LLGYSNSAINPIIYCFMSKKFR 293
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
59-296 6.61e-17

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 79.53  E-value: 6.61e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFkMVLSQVQS---PFPSL-CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15379  35 TTIYMLNLATADLLYVCSLPL-LIYNYTQKdywPFGDFtCRLVRFQFYTNLHGSILFLTCISVQRYLGICHPLASWHKKK 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKI-FGICCTIWVLVWTGSIPIYSFHG---KVEKYMCFhNMSDDTWSAKvFFP----LEVFGFLLPmgimgFCCSRSIH 206
Cdd:cd15379 114 GKKLtWLVCGAVWLVVIAQCLPTFVFAStgtQRNRTVCY-DLSPPARSTA-YFPygitLTRTGFLLP-----FAARLACY 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 207 ILLGRRDHTQD---------WVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFS 277
Cdd:cd15379 187 CSMATILCRVViavavvaapGEKRGKAARMIIVVAAVFLISFLPFHYTKTRYLQVRSWDGGPCTTRQAFAEAYKRTRPFA 266
                       250
                ....*....|....*....
gi 33695107 278 NVNCCLDVFCYYFVIKEFR 296
Cdd:cd15379 267 SMNSVLDPILFYFTQSKFR 285
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
58-299 8.37e-17

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 79.03  E-value: 8.37e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15373  34 ASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPfseALCKIVRFLFYTNLYCSILFLLCISVHRFLGVCYPVRSLRWLK 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPIYSF---HGKVEKYMCFHNMSDDTWSAKVFFPLEVFG--FLLPMGIMGFCCSRSIHILL 209
Cdd:cd15373 114 VRYARIVSVVVWVIVLACQSPVLYFvttSDKGGNITCHDTSSPELFDQFVVYSSVMLVllFCVPFVVILVCYALMVRKLL 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 G-RRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRnSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCY 288
Cdd:cd15373 194 KpSAGTSTNSRSKKKSVKMIIIVLAVFILCFLPFHVTRTLYYSFR-SMDLSCGTLNAINLAYKVTRPLASANSCLDPILY 272
                       250
                ....*....|.
gi 33695107 289 YFVIKEFRMNI 299
Cdd:cd15373 273 FLAGQSFRSNL 283
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
59-296 1.00e-16

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 78.61  E-value: 1.00e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLL-LVLSLPFK-MVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15098  37 TNVFILNLSIADLFfLLFCVPFQaTIYSLPEWVFGAfMCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTR 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSFHGKVEK------YMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHIL- 208
Cdd:cd15098 117 RNALLGVLVIWVLSLAMASPVAVHQDLVHHwtasnqTFCWENWPEKQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLh 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 209 -LGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHL-GFFLQF----LVRNSFIvecrakqsisfFLQLSMCFSNVNCC 282
Cdd:cd15098 197 kKLKNMSKKSERSKKKTAQTVLVVVVVFGISWLPHHIiHLWVEFgdfpLTQASFV-----------LRITAHCLAYANSC 265
                       250
                ....*....|....
gi 33695107 283 LDVFCYYFVIKEFR 296
Cdd:cd15098 266 VNPIIYAFLSENFR 279
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
61-296 2.11e-16

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 77.87  E-value: 2.11e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQV--QSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15193  37 TFVLNLAVADLVFVLTLPFWAASTALggQWLFGEgLCKLSSFIIAVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRC 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHnmSDDTWSAKVFFPLEVF-GFLLPMGIMGFC-CSRSIHILLGRRDHT 215
Cdd:cd15193 117 ALITCCIIWAVSLVLGIPSLVYRNLINESVCVE--DSSSRFFQGISLATLFlTFVLPLIVILFCyCSILVRLRRHFHGAK 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 216 QDWVQQKACIYSIAASLAVFVVSFLPVH-LGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKE 294
Cdd:cd15193 195 RTGRRRRNSLRIVFAIVTAFVLSWLPFNtLKAVRLLLELGGGVLPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRH 274

                ..
gi 33695107 295 FR 296
Cdd:cd15193 275 FR 276
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
61-296 3.70e-16

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 77.11  E-value: 3.70e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPF--KMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15381  37 IYLGNLAAADLLLVCCLPFwaINISNGFNWPFGEfLCKSVNAVIYMNLYSSIYFLMMVSIDRYLALVKTMSSGRMRRPAC 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFhgKVEKYMCFHNMS-------DDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILlg 210
Cdd:cd15381 117 AKLNCLIIWMFGLLMSTPMIVF--RTVMYFPEYNITacvldypSEGWHVALNILLNVVGFLIPLSIITFCSTQIIQVL-- 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 211 RRDHTQDWVQ---QKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFC 287
Cdd:cd15381 193 RNNKMQKFKEiqtERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKLGLISGCRWEDILDIGTQIATFLAYSNSCLNPLL 272

                ....*....
gi 33695107 288 YYFVIKEFR 296
Cdd:cd15381 273 YVIVGKHFR 281
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
59-296 5.30e-16

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 76.45  E-value: 5.30e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPF--KMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYplLVSHLRSPR 136
Cdd:cd15183  35 TSIYLFNLAISDLVFLFTLPFwiDYKLKDDWIFGDAMCKFLSGFYYLGLYSEIFFIILLTIDRYLAIVH--AVFALRART 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTI--WVLVWTGSIP-IYSFHGKVE--KYMC---FHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHIL 208
Cdd:cd15183 113 VTFGIITSIitWALAILASMPcLYFFKSQWEftHHTCsahFPRKSLIRWKRFQALKLNLLGLILPLLVMIICYTGIINIL 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 209 LGRRDHtqdwvQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCY 288
Cdd:cd15183 193 LRRPNE-----KKAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTPSCEQSQQLDLALQVTEVIAYTHCCVNPVIY 267

                ....*...
gi 33695107 289 YFVIKEFR 296
Cdd:cd15183 268 VFVGERFR 275
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
58-298 5.76e-16

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 76.70  E-value: 5.76e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVL-SLPFKMVLSQVQS-PFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd14992  34 ATNYFIASLAISDLLMALfCTPFNFTYVVSLSwEYGHfLCKIVNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQS 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGICCTIWV---------LVWTGSIPIYSFHGKVEKYMC-FHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRS 204
Cdd:cd14992 114 YTTTVIIIITIWVvslllaipqLYYATTEVLFSVKNQEKIFCCqIPPVDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARI 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 205 IHILLGRR---------DHTQdWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLvrNSFIVECRAKQSISFFLqlsMC 275
Cdd:cd14992 194 SRELWFRKvpgfsikevERKR-LKCKRRVIKMLVCVVVLFVICWLPFHLFFLLRDF--FPLIMKEKHTLQVYYFL---HW 267
                       250       260
                ....*....|....*....|...
gi 33695107 276 FSNVNCCLDVFCYYFVIKEFRMN 298
Cdd:cd14992 268 IAMSNSMYNPIIYVTLNNNFRKN 290
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
61-296 7.39e-16

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 76.27  E-value: 7.39e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMV--LSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLV-SHLRsPR 136
Cdd:cd15376  38 VFSFNLAVSDLLYALSLPLLAAyyYPPKNWRFgEAACKLERFLFTCNLYGSIFFITCISLNRYLGIVHPFFTrSHVR-PK 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSF-------HGKVEkymCFHNMSDDtwSAKVFFP----LEVFGFLLPMGIMGFCCSRSI 205
Cdd:cd15376 117 HAKLVSLAVWLLVAALSAPVLSFshleverHNKTE---CLGTAVDS--RLPTYLPyslfLAVVGCGLPFLLTLASYLAIV 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 206 HILLgrRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHlgfFLQ--FLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCL 283
Cdd:cd15376 192 WAVL--RSPGITTLEKRKVAALVAVVVALYAVSFVPYH---ILRnlNLYRRLQWLKAAASLRIYFAYQVTKGLVTLNMCI 266
                       250
                ....*....|...
gi 33695107 284 DVFCYYFVIKEFR 296
Cdd:cd15376 267 HPLLYMAVADSIR 279
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
58-296 9.29e-16

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 75.80  E-value: 9.29e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKMV--LSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd14974  33 VNTVWFLNLALADFLFCLFLPFLIVyiAMGHHWPFGSvLCKLNSFVISLNMFASVFLLTAISLDRCLLVLHPVWAQNHRT 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGICCTIWVLVWTGSIP------IYSFHGKVEKYMCFHNMSDDTWSAK--VFFPLEVFGFLLPMGIMGFCcsrsiH 206
Cdd:cd14974 113 VRLASVVCVGIWILALVLSVPyfvfrdTVTHHNGRSCNLTCVEDYDLRRSRHkaLTVIRFLCGFLLPLLIIAIC-----Y 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 207 ILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSfivecrAKQSISFFLQLSMCFSNVNCCLDVF 286
Cdd:cd14974 188 SVIAVKLRRKRLAKSSKPLRVLLAVVVAFFLCWLPYHVFALLELVAAAG------LPEVVLLGLPLATGLAYFNSCLNPI 261
                       250
                ....*....|
gi 33695107 287 CYYFVIKEFR 296
Cdd:cd14974 262 LYVFMGQDFR 271
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
59-249 1.01e-15

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 75.98  E-value: 1.01e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKM-VLSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd14975  35 TMLLVLNLALADLAVLLTLPVWIyFLATGTWDFgLAACKGCVYVCAVSMYASVFLITLMSLERFLAVSRPFVSQGWRAKA 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSFH---GKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSrsihiLLGRRD 213
Cdd:cd14975 115 LAHKVLAIIWLLAVLLATPVIAFRhveETVENGMCKYRHYSDGQLVFHLLLETVVGFAVPFTAVVLCYS-----CLLRRL 189
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 33695107 214 HTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQ 249
Cdd:cd14975 190 RRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLE 225
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
60-299 1.14e-15

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 75.52  E-value: 1.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLLVLSLPFKMV--LSQVQSPFPSL-CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15114  35 AVWFLNLAVADLLCCLSLPILAVpiAQDGHWPFGAAaCKLLPSLILLNMYASVLLLTAISADRCLLVLRPVWCQNHRRAR 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSF-----HGKVEKYMCFHNMSDDT---WS-AKVFFpleVFGFLLPMGIMGFCcsrsiHI 207
Cdd:cd15114 115 LAWIACGAAWLLALLLTVPSFIYrrihqEHFPEKTVCVVDYGGSTgveWAvAIIRF---LLGFLGPLVVIASC-----HG 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 208 LLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVH-LGFFLQFLVRNSfIVECRAKQSISfflqLSMCFSNVNCCLDVF 286
Cdd:cd15114 187 VLLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYHvVGLIIAASAPNS-RLLANALKADP----LTVSLAYINSCLNPI 261
                       250
                ....*....|...
gi 33695107 287 CYYFVIKEFRMNI 299
Cdd:cd15114 262 IYVVAGRGFRKSL 274
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
46-296 1.48e-15

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 75.25  E-value: 1.48e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  46 STFLKNRWPDYAATSIYMINLAVFDLLLVL-SLPFKMVLSQVQS-PFPSL-CTLVECLYFVSMYGSVFTICFISMDRFLA 122
Cdd:cd15097  23 AVLLRSGQSGHNTTNLFILNLSVADLCFILfCVPFQATIYSLEGwVFGSFlCKAVHFFIYLTMYASSFTLAAVSVDRYLA 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 123 IRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVE---KYMCFHNMSDdtWSAKVF-FPLEVFGFLLPMGIMG 198
Cdd:cd15097 103 IRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDyanSTVCMPGWEE--ARRKAMdTCTFAFGYLIPVLVVS 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 199 FCCSRSIHILLGRRDHTQDWVQQKAC----IYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFivecraKQSISFFLQLSM 274
Cdd:cd15097 181 LSYTRTIKYLWTAVDPLEAMSESKRAkrkvTKMIIIVTALFCLCWLPHHVVILCYLYGDFPF------NQATYAFRLLSH 254
                       250       260
                ....*....|....*....|..
gi 33695107 275 CFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15097 255 CMAYANSCLNPIVYALVSKHFR 276
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
60-296 1.60e-15

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 75.24  E-value: 1.60e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLLVLSLPFKMVLSQVQS-PFPSL-CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15166  36 TVYMMNVALVDLIFILSLPFRMVYYAKDEwPFGDYfCRILGALTVFYPSIALWLLAFISADRYMAIVQPKHAKELKNTPK 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHN---MSDDTWSAKV---FFPLEVFGFLLPMGIMGFCCSRSIHILL-G 210
Cdd:cd15166 116 AVLACVGVWIMTLASTFPLLFLYEDPDKASNFTTclkMLDIIHLKEVnvlNFTRLIFFFLIPLFIMIGCYLVIIHNLVhG 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 211 RRDHTQDWVQQKAcIYSIAASLAVFVVSFLPVHLGFflqflvrnSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYF 290
Cdd:cd15166 196 RTSKLKPKVKEKS-IRIIITLIVQVLVCFVPFHICF--------AFLMLQNGDNSYNPWAAFTTFLMNLSTCLDVILYYI 266

                ....*.
gi 33695107 291 VIKEFR 296
Cdd:cd15166 267 VSKQFQ 272
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
57-299 1.72e-15

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 75.22  E-value: 1.72e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  57 AATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLlvSHLR 133
Cdd:cd15370  33 HPAVIYMANLALADLLFVIWFPLKIAYHINGNNWiygEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPM--SHSR 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKI-FGICCTIWVLVWTGSIPIYSFHGKV-----EKYMCFHNMSDDTWSA---KVFFPLEVFGFLLPMGIMGFCCSRS 204
Cdd:cd15370 111 KKANIaIGISLAIWLLILLVTIPLYLVKQTVfipalDITTCHDVLPEQLLVGdmfNYFLSLAIGVFLFPAFLTAVAYVLM 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 205 IHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLgfflqFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLD 284
Cdd:cd15370 191 IRALKSSINDESIEKKRKRAIKLIVTVLVMYLICFTPSNL-----LLVVHYFLLKNQGQSSVYAFYITALCLSTLNSCID 265
                       250
                ....*....|....*
gi 33695107 285 VFCYYFVIKEFRMNI 299
Cdd:cd15370 266 PFVYYFVSHDFRDHV 280
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
59-296 2.15e-15

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 75.16  E-value: 2.15e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15117  34 TTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPfgwFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVWARNHRTP 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSFHGKVE---KYMCFHNMSDDTWSAK-VFFPLE--------------VFGFLLPMGIM 197
Cdd:cd15117 114 ARAALVAVGAWLLALALSGPHLVFRDTRKengCTHCYLNFDPWNETAEdPVLWLEtvvqrlsaqvitrfVLGFLVPLVII 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 198 GFCCSrsihiLLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVEcrAKQSISFFLQLSMCFS 277
Cdd:cd15117 194 GGCYG-----LIAARLWREGWVHSSRPFRVLTAVVAAFFLCWFPFHLVSLLELVVILNQKED--LNPLLILLLPLSSSLA 266
                       250
                ....*....|....*....
gi 33695107 278 NVNCCLDVFCYYFVIKEFR 296
Cdd:cd15117 267 CVNSCLNPLLYVFVGRDFR 285
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
25-296 2.31e-15

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 74.95  E-value: 2.31e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  25 AVHIPTFVLGLLLNLLAIHGFSTFLKnrwpDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPF---PSLCTLVECLY 101
Cdd:cd15377   5 AVYILVFITGFLGNSVAIWMFVFHMK----PWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWifgDAMCKLQRFIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 102 FVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHG----KVEKYMCFHNMSDDTW 177
Cdd:cd15377  81 HVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGtgvrKNKTITCYDTTSDEYL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 178 SAKVFFPL--EVFGFLLPMgIMGFCCSRSIHILLGRRDHTQDWVQ----QKACIYSIAASLAVFVVSFLPVHLGFFLQFL 251
Cdd:cd15377 161 RSYFIYSMctTVAMFCVPF-ILILGCYGLIVRALIYKDMKYTEENnaplRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLR 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 33695107 252 VRNSFIVE--CRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15377 240 ARLDFQTPamCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFR 286
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
61-291 3.11e-15

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 74.45  E-value: 3.11e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLP--FKMVLSQ-VQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15366  37 VYLLNLSVSDLLYIATLPlwIDYFLHRdNWIHGPESCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKT 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVL-VWTGSIPIYS---FHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSrsiHILLGRRD 213
Cdd:cd15366 117 AVAVSAVVWAIeIGANSAPLFHdelFRDRYNHTFCFEKYPMEDWVAWMNLYRVFVGFLFPWVLMLFSYR---GILRAVRG 193
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33695107 214 HTQDWVQQKACIYSIAASL-AVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFV 291
Cdd:cd15366 194 NVSTEQQEKAKIKRLALSLiAIVLLCFAPYHVLLLSRSVVYLGKPCDCGFEERVFTAYHVSLALTSLNCVADPILYCLV 272
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
59-299 4.91e-15

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 73.65  E-value: 4.91e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSL-CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15173  35 TDIFLVNLAVADLLFLCTLPFWAYSAAHEWIFGTVmCKITNGLYTINLYSSMLILTCITVDRFIVIVQATKAHNCHAKKM 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFG--ICCTIWVLVWTGSIP--IYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRD 213
Cdd:cd15173 115 RWGkvVCTLVWVISLLLSLPqfIYSEVRNLSSKICSMVYPPDAIEVVVNIIQMTVGFFLPLLAMIICYSVIIKTLLHAKG 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 214 htqdwVQQKACIYSIAASLAVFVVSFLPVHLGFFLQflvrnSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIK 293
Cdd:cd15173 195 -----FQKHKSLKIIFVVVAVFILTQLPYNIMKLIR-----TLHIENTDSTNFKYAILITEAIAYLHACLNPILYAFVGV 264

                ....*.
gi 33695107 294 EFRMNI 299
Cdd:cd15173 265 KFRKNF 270
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
59-296 5.39e-15

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 73.55  E-value: 5.39e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15182  35 TNIFILNLAISDLLFTFTLPFWASYHSSGWIFGEiLCKAVTSIFYIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRY 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHGKVEK----YMCfhNMSDDTWSAKVFFPLEVFgFLLPMGIMGFCCSRSIHILLGRRD 213
Cdd:cd15182 115 ASLVSVAVWVISILASLPELILSTVMKSdedgSLC--EYSSIKWKLGYYYQQNLF-FLIPLGIIVYCYVRILQTLMRTRT 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 214 HtqdwvQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRnSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIK 293
Cdd:cd15182 192 M-----RKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSLKD-LTIPICECSKQLDYAFYICRNIAFSHCCLNPVFYVFVGV 265

                ...
gi 33695107 294 EFR 296
Cdd:cd15182 266 KFR 268
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
60-296 6.06e-15

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 73.26  E-value: 6.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS---LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15115  35 TIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYgrfLCKLLPSIIVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVL 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSFHGKVEKYMcfHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHtq 216
Cdd:cd15115 115 LACLLCGCIWILALLLCLPVFIYRTTVTDGN--HTRCGYDFLVAITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFA-- 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 217 dWVQQKAcIYSIAASLAVFVVSFLPVH-LGFFLQFLVRNSfivecraKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEF 295
Cdd:cd15115 191 -KSQSKT-FRVIIAVVVAFFVCWAPYHiIGILSLYGDPPL-------SKVLMSWDHLSIALAYANSCLNPVLYVFMGKDF 261

                .
gi 33695107 296 R 296
Cdd:cd15115 262 K 262
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
54-244 1.37e-14

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 72.83  E-value: 1.37e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  54 PDYAATSIYMINLAVFDLLLVLSLPFKMVL-SQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSH 131
Cdd:cd15378  30 KNWKSSNIYLFNLSVSDLAFLCTLPMLVYSySNGQWLFgDFLCKSNRYLLHANLYSSILFLTFISIDRYLLIKYPFREHI 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 132 LRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEK---YMC--FHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIH 206
Cdd:cd15378 110 LQKKRSAVAISLAIWVLVTLELLPILTFIGPNLKdnvTKCkdYASSGDATNSLIYSLFLTVTGFLIPLCVMCFFYYKIAL 189
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 33695107 207 ILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHL 244
Cdd:cd15378 190 FLKNRNRQLANATSFEKPLTLVILAVVIFSVLFTPYHV 227
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
53-296 1.38e-14

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 72.52  E-value: 1.38e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  53 WPDYAatsIYMINLAVFDLLLVLSLPFKMVLS---QVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLV 129
Cdd:cd15199  32 WKPYA---VYLLNLVLADVLLLICLPFKAYFYlngNRWSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFRVVHPRGK 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 130 SHLRSPRKIFGICCTIWVLVWTGSIPIY--SFHGKVEKYMCFHNMSD----DTWSAKVFFplevFGFLLPMGIMGFCCSR 203
Cdd:cd15199 109 KNSLSLQAAPYISFLVWLLLVGLTIPTLlaSQPKNFTECNSFSPKDDedfsDTWQEAVFF----LQFLLPFGLIVFCTVR 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 204 SIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSfiVECRAKQSISFFLQLSMCFSNVNCCL 283
Cdd:cd15199 185 IIRRLKKRLRDVGKQPKLQRAMALVTSVVVVFGFCFLPCFLARVLMLIFQNK--ESCNALNIAVHTYDVTMCLTYLNSVL 262
                       250
                ....*....|...
gi 33695107 284 DVFCYYFVIKEFR 296
Cdd:cd15199 263 DPIVYCFSSPTFR 275
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
59-296 1.45e-14

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 72.55  E-value: 1.45e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPF--KMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVshLRSPR 136
Cdd:cd15185  35 TNIYLLNLAISDLLFLFTLPFwiHYVRWNNWVFGHGMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFA--LRART 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTI--WVLVWTGSIPIYSFH---GKVEKYMC---FHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHIL 208
Cdd:cd15185 113 VTFGIITSIitWGLAVLAALPEFIFYetqELFEEFLCsplYPEDTEDSWKRFHALRMNIFGLALPLLIMVICYTGIIKTL 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 209 LGRRDHtqdwvQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCY 288
Cdd:cd15185 193 LRCPSK-----KKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFFETDCERSKHLDLAMQVTEVIAYTHCCINPVIY 267

                ....*...
gi 33695107 289 YFVIKEFR 296
Cdd:cd15185 268 AFVGERFR 275
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
56-293 1.56e-14

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 72.52  E-value: 1.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  56 YAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHL 132
Cdd:cd15371  31 SVCTAIFYANLAISDLLFCITLPFKIVYHLNGNNWvfgETMCRIITITFYGNMYCSILLLTCISINRYLAIVHPFIYRSL 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 133 RSPRKIFGICCTIWVLVWTGSIPIY----SFHGKVEKYMCFHNMSDDTWSAKVFF-----PLEVFGFLLPMGIMGFCCSR 203
Cdd:cd15371 111 PKKTYAVLICALVWTIVFLYMLPFFilkqTYYLKELNITTCHDVLPECEQNSNFQfyyfiSMAVFGFLIPLVITIFCYIS 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 204 SIHILLGrrdHTQDWVQQkacIYSIAASLAVFVVSFLPVHLgfflqFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCL 283
Cdd:cd15371 191 IIRTLNA---YEHKWFWY---VKITALVLIIFTICFAPSNV-----ILIIHHFNYYYFNNDNLYSIYLIALCLGSLNSCL 259
                       250
                ....*....|
gi 33695107 284 DVFCYYFVIK 293
Cdd:cd15371 260 DPFLYFLMSK 269
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
61-291 2.94e-14

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 71.72  E-value: 2.94e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPF--KMVLSQVQSPFPSL-CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15367  37 IYLCNLTVADLLYIFSLPFwlQYVLQHDNWTYSELlCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKA 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSfHGKVEK-----YMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGF---CCSRSIHILL 209
Cdd:cd15367 117 ATLVSTVIWLKELMTCVFFFL-HGEISKdkenhSVCFEHYPIKAWEHNINYYRFYAGFLFPIFLLSFsycRILRAVRKSH 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 GRRDHTQDWVQqkaciYSIAASLAVFVVSFLPVHlgffLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYY 289
Cdd:cd15367 196 GTQKSQKIQIK-----RLVLSTVVIFLVCFGPYH----ILLLVRSVFERDCNFAEGIFNYYHFSLLLTSFNCVADPVLYC 266

                ..
gi 33695107 290 FV 291
Cdd:cd15367 267 FA 268
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
52-296 4.37e-14

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 71.32  E-value: 4.37e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  52 RWPDYAATSIYMINLAVFDLLLVLSLPFKM--VLSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLL 128
Cdd:cd14991  28 HSRTWKANTVYLFNLVLADFLLLICLPFRIdyYLRGEHWIFgEAWCRVNLFMLSVNRSASIAFLTAVALDRYFKVVHPHH 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 129 VSHLRSPRKIFGICCTIWVLVWTGSIP-----IYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSR 203
Cdd:cd14991 108 RVNRMSVKAAAGVAGLLWALVLLLTLPlllstLLTVNSNKSSCHSFSSYTKPSLSIRWHNALFLLEFFLPLGLIVFCSVR 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 204 SIHILLGRRDHTQDWVQQKAcIYSIAASLAVFVVSFLP-VHLGFFLQFLVRNSfivECRAKQSISFFLQLSMCFSNVNCC 282
Cdd:cd14991 188 IACNLRIRQSLGKQARVQRA-IRLVFLVVIVFVLCFLPsIIAGLLALVFKNLG---SCRCLNSVAQLFHISLAFTYLNSA 263
                       250
                ....*....|....
gi 33695107 283 LDVFCYYFVIKEFR 296
Cdd:cd14991 264 LDPVIYCFSSPWFR 277
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
59-296 5.99e-14

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 70.55  E-value: 5.99e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPllVSHLRSPRK 137
Cdd:cd15184  35 TDIYLLNLAISDLLFLLTLPFWAHYAANEWVFgNAMCKLLTGLYHIGFFSGIFFIILLTIDRYLAIVHA--VFALKARTV 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTI--WVLVWTGSIPIYSFHgKVEK----YMC---FHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHIL 208
Cdd:cd15184 113 TFGVVTSVvtWVVAVFASLPGIIFT-KSQKegshYTCsphFPPSQYQFWKNFQTLKMNILGLVLPLLVMIICYSGILKTL 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 209 LGRRDHTqdwvQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCY 288
Cdd:cd15184 192 LRCRNEK----KRHKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPVIY 267

                ....*...
gi 33695107 289 YFVIKEFR 296
Cdd:cd15184 268 AFVGEKFR 275
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
58-244 7.32e-14

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 70.49  E-value: 7.32e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKM---VLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15375  34 SSTIIMLNLALTDLLYVTSLPFLIyyyINGESWIFGEFMCKFIRFIFHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQK 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPIYSFHGKVEK---YMCFHNMSDDTWSAKVFFP--LEVFGFLLPMGIMGFCCSRSIHIlL 209
Cdd:cd15375 114 RRWAIVACAVVWVISLAEVSPMTFLITTKEKnnrTICLDFTSSDNLNTIWWYNwiLTVLGFLLPLVIVTLCYTRIIYT-L 192
                       170       180       190
                ....*....|....*....|....*....|....*
gi 33695107 210 GRRDHTQDWVQQKACIYSIAAsLAVFVVSFLPVHL 244
Cdd:cd15375 193 AKGPHTGSASKQKARRLIILI-LLVFYVCFLPFHI 226
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
59-299 9.36e-14

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 70.16  E-value: 9.36e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPF---KMVLSQVQSPFpsLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYplLVSHLRSP 135
Cdd:cd15176  35 TDVYILNLAVADLLLLFTLPFwaaDAVNGWVLGTA--MCKITSALYTMNFSCGMQFLACISVDRYVAITK--ATSRQFTG 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIP---IYSFHGKVEKYMCFHNMSDDT-WSAKVFFP-LEV-FGFLLPMGIMGFCCSRSIHILL 209
Cdd:cd15176 111 KHCWIVCLCVWLLAILLSIPdlvFSTVRENSDRYRCLPVFPPSLvTSAKATIQiLEVlLGFVLPFLVMVFCYSRVARALS 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 gRRDHTQDWVQQKACIysiaASLAVFVVSFLPVHL-GFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCY 288
Cdd:cd15176 191 -RTPNVKKSRALKVLL----AVVGVFIVTQLPYNVvKFYRAIDVIYLLITDCSMSKTLDIAIQVTESIALFHSCLNPVLY 265
                       250
                ....*....|.
gi 33695107 289 YFVIKEFRMNI 299
Cdd:cd15176 266 VFMGASFKSHI 276
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
59-244 1.94e-13

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 69.46  E-value: 1.94e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKM-VLSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15121  35 TCILVLNLALADAAVLLTAPFFLhFLSGGGWEFgSVVCKLCHYVCGVSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKR 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSFHGKVEKY--MCFHNMSDDTWSAKVFFPL--EVFGFLLPMGIMGFCCSrsihiLLGRR 212
Cdd:cd15121 115 SVRALLLAIWIVAFLLSLPMPFYRTVLKKNinMKLCIPYHPSVGHEAFQYLfeTITGFLLPFTAIVTCYS-----TIGRR 189
                       170       180       190
                ....*....|....*....|....*....|..
gi 33695107 213 DHTQDWVQQKACIYSIAASLAVFVVSFLPVHL 244
Cdd:cd15121 190 LRSARFRRKRRTNRLVVLIIATFALFWLPYHV 221
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-200 2.06e-13

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 69.03  E-value: 2.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPF-KMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15093  34 VTNIYILNLAIADELFMLGLPFlAASNALRHWPFGSvLCRLVLSVDGINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRP 113
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSFHGKVEK----YMCFHNMSDDT--WSAKVFFPLEVFGFLLPMGIMGFC 200
Cdd:cd15093 114 RVAKVVNLAVWVASLLVILPVVVFAGTRENqdgsSACNMQWPEPAaaWSAGFIIYTFVLGFLLPLLIICLC 184
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
52-296 2.08e-13

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 69.45  E-value: 2.08e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  52 RWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLL 128
Cdd:cd15374  28 RMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPfgvVACKIVRFLFYANLYCSILFLTCISVHRYVGICHPIR 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 129 VSHLRSPRKIFGICCTIWVLVWTGSIPIYSF---HGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFL--LPMGIMGFCCSR 203
Cdd:cd15374 108 ALRWVKPRHAYLICASVWLVVTVCLVPNLIFvttSRKDNITLCHDTTRPEEFDHYVHYSSAVMVLLfgIPCLVIVVCYGL 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 204 SIHILLGRR---DHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRnSFIVECRAKQSISFFLQLSMCFSNVN 280
Cdd:cd15374 188 MARRLCKPRvgsSRQQGPSSKKRSLKTIIMVLTVFAICFVPFHITRTLYYVAR-LLKADCDTLNIINVTYKVTRPLASAN 266
                       250
                ....*....|....*.
gi 33695107 281 CCLDVFCYYFVIKEFR 296
Cdd:cd15374 267 SCLDPILYFLAGDKYR 282
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
59-299 6.92e-13

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 67.86  E-value: 6.92e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMV--LSQVQSPFPSL-CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd14987  35 THLYILNLAIADLCVVATLPVWVVslVQHNQWPMGEFtCKITHLIFSINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKK 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSFHGKVEKymcfhNMSDDTWsAKVFFPLEVF--------------GFLLPmgimgFCC 201
Cdd:cd14987 115 IVRRIICVLVWLLAFVASLPDTYFLKTVTS-----PSNNETY-CRSFYPEESFkewligmelvsivlGFVIP-----FPI 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 202 SRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFI-VECRAKQSISFFLQLSMCFSNVN 280
Cdd:cd14987 184 IAVFYFLLARAISASSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDILSFLHLIpFSCQLENFLYAALHVTQCFSLVH 263
                       250
                ....*....|....*....
gi 33695107 281 CCLDVFCYYFVIKEFRMNI 299
Cdd:cd14987 264 CCVNPILYSFINRNYRYEL 282
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
58-296 7.09e-13

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 67.63  E-value: 7.09e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKMVLSQV-QSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15970  34 ATNIYILNLAIADELLMLSVPFLVTSTLLrHWPFGSlLCRLVLSVDAINMFTSIYCLTVLSIDRYIAVVHPIKAARYRRP 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSFHGKVEK----YMCFHNMSDDTWSAKVFFPLEVF--GFLLPMGIMGFCcsrSIHILL 209
Cdd:cd15970 114 TVAKMVNLGVWVFSILVILPIIIFSNTAPNsdgsVACNMQMPEPSQRWLAVFVVYTFlmGFLLPVIAICLC---YILIIV 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 GRR--DHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVrNSFivecrAKQSISFFLQLSMCFSNVNCCLDVFC 287
Cdd:cd15970 191 KMRvvALKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLV-SVF-----VGQHDATVSQLSVILGYANSCANPIL 264

                ....*....
gi 33695107 288 YYFVIKEFR 296
Cdd:cd15970 265 YGFLSDNFK 273
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
60-298 7.71e-13

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 67.46  E-value: 7.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15192  36 NIFLLNLALADLCFLITLPLWAAYTAMEYHWPfgnFLCKIASALVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLV 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIY-----SFHGKVEKYMC--FHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILL 209
Cdd:cd15192 116 VARVTCIVIWLLAGVASLPAIihrdvFFIENTNITVCafHYPSQNSTLLVGLGLMKNLLGFLIPFLIILTCYTLIGKALK 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 GRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYY 289
Cdd:cd15192 196 KAYEIQRNKPRNDEIFKMIMAVVLFFFFCWIPHQIFTFLDVLIQLKVIQDCHIADIVDTAMPFTICIAYFNSCLNPILYG 275

                ....*....
gi 33695107 290 FVIKEFRMN 298
Cdd:cd15192 276 FVGKNFRKK 284
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
58-296 1.36e-12

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 66.81  E-value: 1.36e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKMVLSQVQS-PFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15092  34 ATNIYIFNLALADTLVLLTLPFQGTDIFLGFwPFGNaLCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTP 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIY---SFHGKVEKYMCFHNMSD--DTWSAKVFFPLEVFGFLLPMGIMGFCCS------RS 204
Cdd:cd15092 114 HKAKVVNVCIWALASVVGVPVMvmgSAQVEDEEIECLVEIPTpqDYWDPVFGICVFLFSFIIPVLIISVCYSlmirrlRG 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 205 IHILLGRRDHTQDWVQQKACIYSIaasLAVFVVSFLPVHLgfflqFLVRNSFIVECRAKQSISfFLQLSMCFSNVNCCLD 284
Cdd:cd15092 194 VRLLSGSKEKDRNLRRITRLVLVV---VAVFVGCWTPIQI-----FVLAQGLGVQPSSETAVA-ILRFCTALGYVNSSLN 264
                       250
                ....*....|..
gi 33695107 285 VFCYYFVIKEFR 296
Cdd:cd15092 265 PVLYAFLDENFK 276
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
52-296 1.57e-12

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 66.66  E-value: 1.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  52 RWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQS--PF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLL 128
Cdd:cd15922  28 RIKQWSSGTILQFNLALSDAIITPAAPLLIAYFSLGShwPFgQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVHYNW 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 129 VSHLRSPRKIFGICCTIWVLVWTGSIPIY-----SFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSR 203
Cdd:cd15922 108 KSLWKKKSFMKKLCLGVWLLLFVQGLPFFfvlktSVIDGKTKCLSIHQSELSLLYFVWNFVLLILGFLLPFGVSLTCYAL 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 204 -SIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCC 282
Cdd:cd15922 188 lGASIAKMNSNNARGRAMKAKSLQMIGISLVIFIICFVPLHVTRTVGVVVKLFYPESCTLLHKVEVAYYISWVLTGVNCC 267
                       250
                ....*....|....
gi 33695107 283 LDVFCYYFVIKEFR 296
Cdd:cd15922 268 LDPLLYCFASEKFR 281
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
58-296 1.58e-12

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 66.52  E-value: 1.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKMVLSQVQS-PFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15091  34 ATNIYIFNLALADALVTTTMPFQSTVYLMNSwPFGDvLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSFHGK--------VEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCS----- 202
Cdd:cd15091 114 LKAKIINICIWLLSSSVGISAIVLGGTkvredvdsTECSLQFPDDDYSWWDTFMKICVFIFAFVIPVLIIIVCYTlmilr 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 203 -RSIHILLGRRDHTQDWVQQKACIYSIaasLAVFVVSFLPVHLGFFLQFLVRNSfivECRAKQSISFFlqlSMCFSNVNC 281
Cdd:cd15091 194 lKSVRLLSGSREKDRNLRRITRLVLVV---VAVFVVCWTPIHIFILVEALGSVS---HSTAAVSSYYF---CIALGYTNS 264
                       250
                ....*....|....*
gi 33695107 282 CLDVFCYYFVIKEFR 296
Cdd:cd15091 265 SLNPILYAFLDENFK 279
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
59-298 2.07e-12

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 66.33  E-value: 2.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYpllVSHLRSPRK 137
Cdd:cd15179  35 TDKYRLHLSVADLLFVLTLPFWAVDAAANWYFGNfLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVH---ATNSQRPRK 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFG---ICCTIWVLVWTGSIPIYSFHGKVE---KYMCFH---NMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSrsihIL 208
Cdd:cd15179 112 LLAekvVYVGVWLPALLLTVPDLVFAKVSElddRYICDRiypEDTFELWVVAFRFQHILVGLVLPGLVILTCYC----II 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 209 LGRRDHTQDWVQQKACIYSIAASLAVFVVsFLPVHLGFFLQFLVRNSFI-VECRAKQSISFFLQLSMCFSNVNCCLDVFC 287
Cdd:cd15179 188 ISKLSHSKGHQKRKALKTTVILILAFFAC-WLPYYIGISIDTFMLLEIIkQSCEMEQTVHKWISITEALAFFHCCLNPIL 266
                       250
                ....*....|.
gi 33695107 288 YYFVIKEFRMN 298
Cdd:cd15179 267 YAFLGAKFKTS 277
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
58-296 2.59e-12

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 66.03  E-value: 2.59e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKMVLSQVQS-PFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15973  34 ATNIYILNLAIADELFMLSVPFLAASAALQHwPFGSaMCRTVLSVDGINMFTSVFCLTVLSVDRYIAVVHPLRAARYRRP 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 R--KIFGICCTIWVLVWTGSIPIY--SFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCcsrSIHILLGR 211
Cdd:cd15973 114 TvaKMINICVWILSLLVISPIIIFadTATRKGQAVACNLIWPHPAWSAAFVIYTFLLGFLLPVLAIGLC---YILIIGKM 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 212 RDHTQD--WVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVrNSFIVECRAKQSisfflQLSMCFSNVNCCLDVFCYY 289
Cdd:cd15973 191 RAVALKagWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLL-NLFLPRLDATVN-----HASLILSYANSCANPILYG 264

                ....*..
gi 33695107 290 FVIKEFR 296
Cdd:cd15973 265 FLSDNFR 271
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
61-298 3.64e-12

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 65.55  E-value: 3.64e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKM--VLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15088  37 IFIFNLAVADLLFMLGMPFLIhqFAIDGQWYFGEvMCKIITALDANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFV 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVL-------VWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAKVFFPLevfGFLLPMGIMGFCCSRSIHILL- 209
Cdd:cd15088 117 AKLVNVGLWAAsflsilpVWVYSSLIYFPDGTTFCYVSLPSPDDLYWFTIYHFIL---GFAVPLVVITVCYILILHRLAr 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 ----GRRDHTQDWVQQKACIysIAASLAVFVVSFLPVHLGFFLQFLVRnsfivecRAKQSISFFLQLSMCFSNVNCCLDV 285
Cdd:cd15088 194 gvapGNQSHGSSRTKRVTKM--VILIVVVFIVCWLPFHVVQLVNLAMN-------RPTLAFEVAYFLSICLGYANSCLNP 264
                       250
                ....*....|...
gi 33695107 286 FCYYFVIKEFRMN 298
Cdd:cd15088 265 FVYILVSENFRKR 277
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
58-296 5.36e-12

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 64.97  E-value: 5.36e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKMVLSQVQS-PFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15089  34 ATNIYIFNLALADALATSTLPFQSAKYLMETwPFGElLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSF----HGKVEKYMCFHNMSDDTWSAKVFFPLEV--FGFLLPMGIMGFCCS------R 203
Cdd:cd15089 114 AKAKLINICIWVLSSGVGVPIMVMavtkTPRDGAVVCMLQFPSPSWYWDTVTKICVfiFAFVVPILVITVCYGlmilrlR 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 204 SIHILLGRRDHTQDWVQQKACIYSIAASlavFVVSFLPVHLGFFLQFLV----RNSFIVECrakqsisffLQLSMCFSNV 279
Cdd:cd15089 194 SVRLLSGSKEKDRNLRRITRMVLVVVAA---FIICWTPIHIFVIVWTLVdidrRNPLVVAA---------LHLCIALGYA 261
                       250
                ....*....|....*..
gi 33695107 280 NCCLDVFCYYFVIKEFR 296
Cdd:cd15089 262 NSSLNPVLYAFLDENFK 278
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
61-296 6.14e-12

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 64.85  E-value: 6.14e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVL-SLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIF 139
Cdd:cd14989  37 LYFVNLAVADLILVAdSLIEVFNLNEKYYDIAVLCTFMSLFLQINMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHAR 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 140 GICCTIW---VLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWsakvffpLEV-FGFLLPMGIMGFCCSRSIHILLGRRDHT 215
Cdd:cd14989 117 LSCGLIWmasISATLLPFTAVQAQHTGEVHFCFADVREIQW-------LEVtLGFIIPFSIIGLCYSLIVRVLVRAQKHR 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 216 QDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVEcRAKQSISFFLQLSMCFSNV----NCCLDVFCYYFV 291
Cdd:cd14989 190 RLRPRRQKALRMILVVVLVFFICWLPENVFISIQLLQGTQEPSE-SYDESFRHNHPLTGHIVNLaafsNSCLNPLIYSFL 268

                ....*
gi 33695107 292 IKEFR 296
Cdd:cd14989 269 GETFR 273
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
58-296 7.32e-12

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 64.63  E-value: 7.32e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKMVLSQVQS-PFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15090  34 ATNIYIFNLALADALATSTLPFQSVNYLMGTwPFGNiLCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTP 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 R--KIFGICCtiWVLVWTGSIPIY------SFHGKVEKYMCFHNMSdDTWSAKVFFPLEVFGFLLPMGIMGFCCS----- 202
Cdd:cd15090 114 RnaKIVNVCN--WILSSAIGLPVMfmattkYRQGSIDCTLTFSHPS-WYWENLLKICVFIFAFIMPVLIITVCYGlmilr 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 203 -RSIHILLGRRDHTQDWvqqKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRnsfiVECRAKQSISFFLQLSMCFSnvNC 281
Cdd:cd15090 191 lKSVRMLSGSKEKDRNL---RRITRMVLVVVAVFIVCWTPIHIYVIIKALVT----IPETTFQTVSWHFCIALGYT--NS 261
                       250
                ....*....|....*
gi 33695107 282 CLDVFCYYFVIKEFR 296
Cdd:cd15090 262 CLNPVLYAFLDENFK 276
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
58-295 1.13e-11

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 64.30  E-value: 1.13e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKM--VLSQVQSPF-PSLCTLveCLYFVSM--YGSVFTICFISMDRFLAIRYPLLVSHL 132
Cdd:cd15201  34 SSTVYLFNLAVADFLLIICLPFRTdyYLRGKHWKFgDIPCRI--VLFMLAMnrAGSIFFLTAVAVDRYFRVVHPHHRINS 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 133 RSPRKIFGICCTIWVLVWTGSI--------PIYSFHGKVEKY-MCFHNMSDDTWSaKVFFPLEvfgFLLPMGIMGFCCSR 203
Cdd:cd15201 112 ISVRKAAIIACGLWLLTIAMTVylltkkhlFPRGNATQCESFnICTGTDSSSNWH-EAMFLLE---FFLPLAIILYCSVR 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 204 SIHILLGRRDHTQDWVqqKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCL 283
Cdd:cd15201 188 IIWQLRGRQLDRHAKI--KRAVQFIMVVAIVFIICFLPSNVTRIAIWILKHTSNEDCQYYRSVDLAFYITISFTYFNSML 265
                       250
                ....*....|..
gi 33695107 284 DVFCYYFVIKEF 295
Cdd:cd15201 266 DPVVYYFSSPSF 277
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
58-296 1.26e-11

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 64.23  E-value: 1.26e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDL-LLVLSLPFKMVLSqvqsPFPS------LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVS 130
Cdd:cd15095  34 VTNYYIVNLAVTDLaFLVCCVPFTAALY----ATPSwvfgdfMCKFVNYMMQVTVQATCLTLTALSVDRYYAIVHPIRSL 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 131 HLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMC-FHNMSDDTWSAKVFFP---LEVFG--FLLPMGIMGFCCSRS 204
Cdd:cd15095 110 RFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYgPQTYCREVWPSKAFQKaymIYTVLltYVIPLAIIAVCYGLI 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 205 IHILLGRRDHTQDWVQ--------QKACIYSIAASLAV-FVVSFLPVHLgfflqFLVRNSFIVECRAKQSISFFLQLSMC 275
Cdd:cd15095 190 LRRLWRRSVDGNNQSEqlseralrQKRKVTRMVIVVVVlFAICWLPNHV-----LNLWQRFDPNFPETYATYALKIAALC 264
                       250       260
                ....*....|....*....|.
gi 33695107 276 FSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15095 265 LSYANSAVNPFVYAFMGENFR 285
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
59-296 2.50e-11

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 63.28  E-value: 2.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQS-PF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15974  35 TNIYILNLAVADELFMLGLPFLATQNAISYwPFgSFLCRLVMTVDGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPR 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSFhGKVEKYMCFHNMS----DDTWSAKVFFPLEVFGFLLPMGIMGFCC--------SRS 204
Cdd:cd15974 115 VAKLINATVWTLSFLVVLPVIIF-SDVQPDLNTCNISwpepVSVWSTAFIIYTAVLGFFGPLLVICLCYllivikvkSSG 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 205 IHILLGRRDHTQDWVQQKACIYsiaasLAVFVVSFLPvhlgFFLQFLVRNSFIV-ECRAKQSISFFLqlsMCFSNVNCCL 283
Cdd:cd15974 194 LRVGSTKRRKSERKVTRMVVII-----VVVFVFCWLP----FYMLNIVNLIVILpEEPAFVGVYFFV---VVLSYANSCA 261
                       250
                ....*....|...
gi 33695107 284 DVFCYYFVIKEFR 296
Cdd:cd15974 262 NPILYGFLSDNFK 274
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
60-299 3.43e-11

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 62.87  E-value: 3.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS---LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15364  36 AVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWgslACKITGYIFFCNIYISILLLCCISIDRFVAVVYALESRGRRRQR 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSFHGKVE--KYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRsihILLGRRDH 214
Cdd:cd15364 116 IAAFISFLIFIVVGLVHSPVFIMREGQTegSHTCFETLQMDTQVAGFYYARFCIGFAIPLAILIFTNYR---IFRSIQTS 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 215 TQDWVQQKACI-YSIAASLAVFVVSFLPVHlgffLQFLVRNSFIV-----ECRAKQSISFFLQLSMCFSNVNCCLDVFCY 288
Cdd:cd15364 193 TSLTPHQKAKVkYLAIAVIVIFLICFAPYH----LVLLVRAIAFSlypngMCGFEERIYTPSVIFLCLSTVNSVADPIIY 268
                       250
                ....*....|.
gi 33695107 289 YFVIKEFRMNI 299
Cdd:cd15364 269 VLVSENVRQDI 279
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
61-179 3.66e-11

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 62.79  E-value: 3.66e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMV--LSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15148  37 IFLINVAIADLLLIICLPFRILyhVNNNQWTLGPlLCKVVGNLFYMNMYISIILLGFISLDRYLKINRSSRRQKFLTRKW 116
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 33695107 138 IFGICCTIWVLVWTGSIP-IYSFHGKVEKYMCFH--NMSDDTWSA 179
Cdd:cd15148 117 SIVACGVLWAVALVGFVPmIVLTEKNEESTKCFQykDRKNAKGKA 161
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
58-245 7.56e-11

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 61.99  E-value: 7.56e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLL-LVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd14979  34 TTNYYLFSLAVSDLLiLLVGLPVELYNFWWQYPWAfgdGGCKLYYFLFEACTYATVLTIVALSVERYVAICHPLKAKTLV 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIPIYSFHGKV---------EKYMCFHNMSDDTWSAKVFFPLEVF-GFLLPMGIMGFCCSR 203
Cdd:cd14979 114 TKRRVKRFILAIWLVSILCAIPILFLMGIQylngplpgpVPDSAVCTLVVDRSTFKYVFQVSTFiFFVLPMFVISILYFR 193
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 33695107 204 SIHILLGRRDHTQDWVQ--------------QKACIYSIAASLAVFVVSFLPVHLG 245
Cdd:cd14979 194 IGVKLRSMRNIKKGTRAqgtrnvelslsqqaRRQVVKMLGAVVIAFFVCWLPFHAQ 249
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
22-149 1.10e-10

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 61.18  E-value: 1.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  22 LQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRwpdYAATSIYMINLAVFDLLLVLSLPFKMV--LSQVQSPFP-SLCTLVE 98
Cdd:cd15169   2 LSFGLYVAAFALGFPLNVLAIRGATAHARLR---LTPSLVYALNLGCSDLLLTVSLPLKAVeaLASGAWPLPaSLCPVFA 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 33695107  99 CLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLV 149
Cdd:cd15169  79 VAHFAPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALV 129
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
59-244 1.47e-10

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 61.01  E-value: 1.47e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPF-KMVLSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15971  35 TNIYILNLAIADELFMLGLPFlAIQVALVHWPFgKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPR 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSFHGKVEKY-MCFHNM----SDDTWSAKVFFPLEVFGFLLPMGIMGFCC--------SR 203
Cdd:cd15971 115 TAKMINMAVWGVSLLVILPIMIYAGVQTKHgRSSCTIiwpgESSAWYTGFIIYTFILGFFVPLTIICLCYlfiiikvkSS 194
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 33695107 204 SIHILLGRRDHTQDWVQQKACIYsiaasLAVFVVSFLPVHL 244
Cdd:cd15971 195 GIRVGSSKRKKSEKKVTRMVSIV-----VAVFVFCWLPFYI 230
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
58-296 1.68e-10

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 60.70  E-value: 1.68e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKMVLSQVQS-PFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPllvshLRS 134
Cdd:cd15203  34 VTNIFILNLAVSDLLLcLVSLPFTLIYTLTKNwPFGSiLCKLVPSLQGVSIFVSTLTLTAIAIDRYQLIVYP-----TRP 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGiCCTIWVLVWTGS----IPIYSFHGKVE-----KYMCFHNMSDDTWSA---KVF-FPLEVFGFLLPMGIMGFCC 201
Cdd:cd15203 109 RMSKRH-ALLIIALIWILSlllsLPLAIFQELSDvpieiLPYCGYFCTESWPSSssrLIYtISVLVLQFVIPLLIISFCY 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 202 SRsIHILLGRRDHTQDWVQQKACI-------------YSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECrakqSISF 268
Cdd:cd15203 188 FR-ISLKLRKRVKKKRGKRTLSSRrrrselrrkrrtnRLLIAMVVVFAVCWLPLNLFNLLRDFEPLPQIDGR----HFYL 262
                       250       260
                ....*....|....*....|....*...
gi 33695107 269 FLQLSMCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15203 263 IFLICHLIAMSSACVNPLLYGWLNDNFR 290
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
61-299 2.01e-10

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 60.64  E-value: 2.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS---LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15194  37 IFISNLAASDFIFLVTLPLWVDKEVVLGPWRSgsfLCKGSSYIISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHN 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIysFHGKV-----EKYMCfhnMSDDTWSAKVFFPLE--VFGFLLPM-GIMGFCCSRSIHILL 209
Cdd:cd15194 117 AKVCCTCVWMLSCLLGLPT--LLSRElkkyeEKEYC---NEDAGTPSKVIFSLVslIVAFFLPLlSILTCYCTIIWKLCH 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 GRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYY 289
Cdd:cd15194 192 HYQKSGKHQKKLRKSIKIVFIVVAAFVFSWMPFNLFKALAIASGLQVEVTCLPYTLAQLGMEVSAPLAFANSCANPFIYY 271
                       250
                ....*....|
gi 33695107 290 FVIKEFRMNI 299
Cdd:cd15194 272 FFDRYIRRAI 281
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
59-299 2.66e-10

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 60.16  E-value: 2.66e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSL---CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15167  35 INIYLINLLTADFLLTLALPVKIAVDLGIAPWKLKifhCQVTACLIYINMYLSIIFLGFVSIDRYLQLTHSSKLYRIQEP 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVW-----TGSIPIYSFHGKVE-KYMCFHNMSDDTWSA-KVFFPLEVF-GFLLPMGIMGFCCSRSIHi 207
Cdd:cd15167 115 GFAKMISAVVWTLVLfimvpNMAIPIKTIEEKPGvGCADFKTEFGRHWHVlTNFICMAIFlNFSAIILISNFLVIRKLY- 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 208 llgRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFC 287
Cdd:cd15167 194 ---RNKDSEEYRNARQALVNILLVTAGYVICFVPYHIVRIPYTLSQSEVITDCSLKRSLFLAKESTLLLAVLNLCFDPIL 270
                       250
                ....*....|..
gi 33695107 288 YYFVIKEFRMNI 299
Cdd:cd15167 271 YFHLSKAFRSKI 282
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
44-243 4.30e-10

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 59.32  E-value: 4.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  44 GFSTFLKNrWPDYAATSIYMINLAVFDLLLVLSLPFKMV--LSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRF 120
Cdd:cd15967  21 GLKSLLAN-WKKLGNINVFVLNLGLADLLYLLTLPFLVVyyLKGRKWIFgQVFCKITRFCFNLNLYGSIGFLTCISVYRY 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 121 LAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVE-KYMCFHNMSDDTWSAKVFFPL--EVFGFLLPMGIM 197
Cdd:cd15967 100 LAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKTNSnGTKCFDTTFNDYLESYLTYSLgwTVTGFVIPLLII 179
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 33695107 198 gFCCSRSIHILLGRRDHTQDWVQQKaCIYSIAASLAVFVVSFLPVH 243
Cdd:cd15967 180 -LGCYGHVVVVLCRNNNVDKGLKQR-CLKLVIILIVLFSVCYIPYH 223
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
59-299 4.99e-10

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 60.03  E-value: 4.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107   59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:PHA02638 132 TDIYIFNLAISDLIFVIDFPFIIYNEFDQWIFGDfMCKVISASYYIGFFSNMFLITLMSIDRYFAILYPISFQKYRTFNI 211
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  138 IFGICCTIWVLVWTGSIPIY-------------SFHGKVEKYMCFHNMSDDTWSAKVF-----FPLEVFGFLLPMGIMGF 199
Cdd:PHA02638 212 GIILCIISWILSLIITSPAYfifeasniifsaqDSNETISNYQCTLIEDNEKNNISFLgrilqFEINILGMFIPIIIFAF 291
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  200 CcsrSIHILLGRRDHTQDWVQQKACIYS--IAASLAVFVVSFLPVHLGFFLQFLVRNSFIVE--CRAKQsISFFLQLSMC 275
Cdd:PHA02638 292 C---YIKIILKLKQLKKSKKTKSIIIVSiiIICSLICWIPLNIVILFATMYSFKGFNSIISEhiCGFIK-LGYAMMLAEA 367
                        250       260
                 ....*....|....*....|....
gi 33695107  276 FSNVNCCLDVFCYYFVIKEFRMNI 299
Cdd:PHA02638 368 ISLTHCCINPLIYTLIGENFRMHL 391
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
52-296 1.03e-09

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 58.28  E-value: 1.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  52 RWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLL 128
Cdd:cd14976  30 KLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPfgtAMCKVVRYVTKLNMYSSIFFLTALSVTRYIAVARALK 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 129 VSHLRSPRKIFGICCTIWVLVWTGSIP--IYS--FHGKVEKYMCFHNMSDDTWSAKVFFPLE-------VFGFLLPMGIM 197
Cdd:cd14976 110 HGWIRKAFGAFATTIAIWAAAALAAIPeaIFStdTWSSVNHTLCLLRFPKNSSVTRWYNWLGmyqlqkvVLGFFLPLGII 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 198 GFCcsrSIHILLGRRDHTQDWVQQKAciySIAASLAVFVVSF----LPVHLGFFLQFLVRNSFIVECRAKQSI-SFFLQL 272
Cdd:cd14976 190 TLS---YLLLLRFLQRKRGGSKRRKS---RVTKSVFIVVLSFficwLPNQALSLWSALIKFDDVPFSDAFFAFqTYAFPV 263
                       250       260
                ....*....|....*....|....
gi 33695107 273 SMCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd14976 264 AICLAHSNSCLNPVLYCLVRREFR 287
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
57-296 1.12e-09

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 58.06  E-value: 1.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  57 AATSIYMINLAVFDLLLVL-SLPFKMVLSQVQSPF--PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15001  32 SVTNVFLASLATADLLLLVfCVPLKTAEYFSPTWSlgAFLCKAVAYLQLLSFICSVLTLTAISIERYYVILHPMKAKSFC 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIPI--------YSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSi 205
Cdd:cd15001 112 TIGRARKVALLIWILSAILASPVlfgqglvrYESENGVTVYHCQKAWPSTLYSRLYVVYLAIVIFFIPLIVMTFAYARD- 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 206 hillgrrdhtqdwvQQKACIYSIAASLAVFVVSFLPVHLGFFLQflvrnSFIVECraKQSISFFLQLSMCF---SNVNCC 282
Cdd:cd15001 191 --------------TRKQVIKMLISVVVLFAVCWGPLLIDNLLV-----SFDVIS--TLHTQALKYMRIAFhllSYANSC 249
                       250
                ....*....|....
gi 33695107 283 LDVFCYYFVIKEFR 296
Cdd:cd15001 250 INPIIYAFMSKNFR 263
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
60-286 1.35e-09

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 57.89  E-value: 1.35e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLLVLSLPF---KMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15118  35 SIWILNLALSDLLATLSLPFftyYLASGHTWELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVA 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSFHGKVEKY----MCFHNMSDDTWSAKVFFPL------------EVFGFLLPMGIMGFC 200
Cdd:cd15118 115 AAKKICGVIWAMALINTIPYFVFRDVIERKdgrkLCYYNFALFSPSPDNNHPIckqrqeglaiskLLLAFLIPLVIIAVS 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 201 CSrSIHILLGRRDHTQDWVQQKAciysIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVN 280
Cdd:cd15118 195 YA-VVSLIIRHRCRRRPGRFVRL----VVSVVVSFALCWAPYHIFSIIEVMAHNQHSLRPLVIQGLPFATTLAFLNSVLN 269

                ....*.
gi 33695107 281 CCLDVF 286
Cdd:cd15118 270 PVLYVF 275
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
59-296 1.79e-09

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 57.50  E-value: 1.79e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQS-PFPSL-CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15972  35 TNIYILNLALADELFMLGLPFLAAQNALSYwPFGSFmCRLVMTVDAINQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPP 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSFHGkVEKYMCFHNMS----DDTWSAKVFFPLEVFGFLLPMGIMGFC----------CS 202
Cdd:cd15972 115 VAKTVNATVWALSFLVVLPVVIFSG-VPGGMGTCHIAwpepAQVWRAGFIIYTATLGFFCPLLVICLCyllivvkvrsSG 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 203 RSIHILLGRRDHTQDWVQQKaciysIAASLAVFVVSFLPvhlgfflqFLVRNSFIVECRAKQSISFF--LQLSMCFSNVN 280
Cdd:cd15972 194 RRVRATSTKRRGSERKVTRM-----VVIVVAAFVLCWLP--------FYALNIVNLVCPLPEEPSLFglYFFVVVLSYAN 260
                       250
                ....*....|....*.
gi 33695107 281 CCLDVFCYYFVIKEFR 296
Cdd:cd15972 261 SCANPIIYGFLSDNFK 276
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
59-296 1.97e-09

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 57.48  E-value: 1.97e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFkMVLSQVQSPF----PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15120  34 NTLWFLHLILSNLIFTLILPF-MAVHVLMDNHwafgTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRT 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPIYSF----HGKVEKYMCFHN--MSDDTWSAKV-----------FFPLEVFGFLLPMGIM 197
Cdd:cd15120 113 NRWASAIVLGVWISAILLSIPYLAFretrLDEKGKTICQNNyaLSTNWESAEVqasrqwihvamFVFRFLLGFLLPFLII 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 198 GFCCSRsihilLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQflvrnsfIVECRAKQSISFFLQLSMCFS 277
Cdd:cd15120 193 TFCYVR-----MALKMKERGLARSSKPFKVMFTAVVSFFVCWLPYHLHSGLV-------LTRGRPPSLTDITLLLTVGTT 260
                       250
                ....*....|....*....
gi 33695107 278 NVNCCLDVFCYYFVIKEFR 296
Cdd:cd15120 261 CFNTCFTPVLYLFVGENFK 279
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
58-296 2.68e-09

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 57.25  E-value: 2.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15068  34 VTNYFVVSLAAADIAVgVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGT 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVL-VWTGSIPIYSFH-------GKVEKYMCFHNMSDDTWSAKV---------FFPLEVFGFLLPMGIMgf 199
Cdd:cd15068 114 RAKGIIAICWVLsFAIGLTPMLGWNncgqpkeGKNHSQGCGEGQVACLFEDVVpmnymvyfnFFACVLVPLLLMLGVY-- 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 200 ccsrsIHILLGRRDHTQDWVQQKAC--------------IYSIAASLAVFVVSFLPVHlgfflqflVRNSFIVECRA-KQ 264
Cdd:cd15068 192 -----LRIFLAARRQLKQMESQPLPgerarstlqkevhaAKSLAIIVGLFALCWLPLH--------IINCFTFFCPDcSH 258
                       250       260       270
                ....*....|....*....|....*....|..
gi 33695107 265 SISFFLQLSMCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15068 259 APLWLMYLAIVLSHTNSVVNPFIYAYRIREFR 290
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
58-297 3.33e-09

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 56.88  E-value: 3.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKMVLS-QVQSPFPSlCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd14968  34 VTNYFIVSLAVADILVgALAIPLAILISlGLPTNFHG-CLFMACLVLVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTG 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVL-VWTGSIPIYSFHGKVEK--------YMC-FHNMSDDTWsaKVFFplEVFGFLL-PMGIMGFccsrs 204
Cdd:cd14968 113 RRAWGAIAVCWVLsFLVGLTPMFGWNNGAPLesgcgeggIQClFEEVIPMDY--MVYF--NFFACVLvPLLIMLV----- 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 205 IHILLGRRDHTQdwVQQKACIYS-------------IAASLAV----FVVSFLPVHlgfflqflVRNSFIVECRAKQSIS 267
Cdd:cd14968 184 IYLRIFRVIRKQ--LRQIESLLRsrrsrstlqkevkAAKSLAIilflFALCWLPLH--------IINCITLFCPECKVPK 253
                       250       260       270
                ....*....|....*....|....*....|
gi 33695107 268 FFLQLSMCFSNVNCCLDVFCYYFVIKEFRM 297
Cdd:cd14968 254 ILTYIAILLSHANSAVNPIVYAYRIRKFRQ 283
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
59-249 7.96e-09

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 55.58  E-value: 7.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPF--PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15122  37 TCILILNLAVADGAVLLLTPFFITFLTRKTWPfgQAVCKAVYYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKA 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSFHGKVEKY-----MCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGR 211
Cdd:cd15122 117 LVRKILLAIWLLALLLALPAFVYRHVWKDEgmndrICEPCHASRGHAIFHYTFETLVAFVLPFGVILFSYSVILVRLKGA 196
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 33695107 212 RDHTQDWVQQkaciySIAASLAVFVVSFLPVHLGFFLQ 249
Cdd:cd15122 197 RFRRRARVEK-----LIAAIVVAFALLWVPYHVVNLLQ 229
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
58-249 8.90e-09

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 55.71  E-value: 8.90e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKMVLSQVQS-PF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPlLVSHLrS 134
Cdd:cd15207  34 VTNYFILNLAVSDLLVgVFCMPFTLVDNILTGwPFgDVMCKLSPLVQGVSVAASVFTLVAIAVDRYRAVVHP-TEPKL-T 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPI--------YSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIH 206
Cdd:cd15207 112 NRQAFVIIVAIWVLALAIMIPQalvlevkeYQFFRGQTVHICVEFWPSDEYRKAYTTSLFVLCYVAPLLIIAVLYVRIGY 191
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 33695107 207 ILLGRRDHTQDWVQQKAC----------IYSIAASLAVFVVSFLPVHLGFFLQ 249
Cdd:cd15207 192 RLWFKPVPGGGSASREAQaavskkkvrvIKMLIVVVVLFALSWLPLHTVTMLD 244
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
57-296 9.55e-09

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 55.67  E-value: 9.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  57 AATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15926  34 SSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLfgkAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSKRRR 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIP--IYSFHGKV-EKYMCFHNMSDDTWSAKVFFPLE-----VFGFLLPMGIMGFCcsrsi 205
Cdd:cd15926 114 GCCSAKWLCVLIWVLAILASLPnaIFSTTATVsNEELCLVKFPDNRGNAQFWLGLYhaqkvLLGFLIPLGIISLC----- 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 206 HILLGRrdhtqdWVQQKACIYSIAASLAVFVVSFLPVHLGFFL-----QFLVRNSFIVECRAKQ-SISFFLQ------LS 273
Cdd:cd15926 189 YLLLVR------FITDKNITGSSTKRRSKVTKSVTIVVLSFFLcwlpnQALTTWGILIKLNVVHfSYEYFTTqvyifpIT 262
                       250       260
                ....*....|....*....|...
gi 33695107 274 MCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15926 263 VCLAHSNSCLNPILYCLMRREFR 285
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
61-173 1.26e-08

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 55.15  E-value: 1.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15116  36 VWFLNLAVADFLFTFFLPFSIAYTAMDFHWPfgrFMCKLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRL 115
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHG-----KVEKYMCFHNMS 173
Cdd:cd15116 116 ASLVSLAVWVVAFFLSSPSFIFRDtapsqNNNKIICFNNFS 156
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
58-296 1.41e-08

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 54.90  E-value: 1.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKMV-LSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd14969  34 PLNLFLLNLALADLLMsVVGYPLSFYsNLSGRWSFgDPGCVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLKAFRLSK 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGIC-CTIWVLVWTgSIPIY---SFHGKVEKYMCFHNMSDDTWSAKVF-FPLEVFGFLLPMGIMGFCCSRSIHILL 209
Cdd:cd14969 114 RRALILIAfIWLYGLFWA-LPPLFgwsSYVPEGGGTSCSVDWYSKDPNSLSYiVSLFVFCFFLPLAIIIFCYYKIYRTLR 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 GRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVhLGFFLQFL----VrnSFIVECRAKQSIS-FFLQLSMCFSNVNCCLD 284
Cdd:cd14969 193 KMSKRAARRKNSAITKRTKKAEKKVAKMVLVMI-VAFLIAWTpyavV--SLYVSFGGESTIPpLLATIPALFAKSSTIYN 269
                       250
                ....*....|..
gi 33695107 285 VFCYYFVIKEFR 296
Cdd:cd14969 270 PIIYVFMNKQFR 281
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
58-296 1.41e-08

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 54.88  E-value: 1.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15925  35 PIDVFVFNLALADFGFALTLPFWAVESALDFHWPfggAMCKMVLTATVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLS 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPIYSFHGKVE---KYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGR 211
Cdd:cd15925 115 TFWAKIITLALWAAALLATVPTAIFATEGEvcgVELCLLKFPSNYWLGAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQH 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 212 RDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSI-SFFLQLSMCFSNVNCCLDVFCYYF 290
Cdd:cd15925 195 KVNQNNRQRQSVIARSVRLVVASFFLCWFPNHVVTFWGVLVKFRAVPWNSTFYFIhTYVFPVTTCLAHSNSCLNPVLYCL 274

                ....*.
gi 33695107 291 VIKEFR 296
Cdd:cd15925 275 MRREFR 280
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
59-157 1.58e-08

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 54.79  E-value: 1.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQS-PF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15094  35 TNLYILNLAVADECFLIGLPFLIVTMILKYwPFgAAMCKIYMVLTSINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPF 114
                        90       100
                ....*....|....*....|.
gi 33695107 137 KIFGICCTIWVLVWTGSIPIY 157
Cdd:cd15094 115 IAKVVCATTWSISFLVMLPII 135
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
61-296 3.66e-08

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 54.14  E-value: 3.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107   61 IYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLairypLLVSHLRSPRKIF 139
Cdd:PHA02834  64 VYLFNIAMSDLMLVFSFPFIIHNDLNEWIFGEfMCKLVLGVYFVGFFSNMFFVTLISIDRYI-----LVVNATKIKNKSI 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  140 GICCTIWVLVWTGSI----PIYSFHGKVEKYMCFHNMSDD-----TWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLG 210
Cdd:PHA02834 139 SLSVLLSVAAWVCSVilsmPAMVLYYVDNTDNLKQCIFNDyhenfSWSAFFNFEINIFGIVIPLIILIYCYSKILYTLKN 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  211 RRDHTqdwvqQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFI-VECRAKQSISFFLQLSMCFSNVNCCLDVFCYY 289
Cdd:PHA02834 219 CKNKN-----KTRSIKIILTVVTFTVVFWVPFNIVLFINSLQSVGLIdIGCYHFKKIVYSIDIAELISFVHCCVNPIIYA 293

                 ....*..
gi 33695107  290 FVIKEFR 296
Cdd:PHA02834 294 FVGKNFK 300
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
61-295 4.04e-08

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 53.64  E-value: 4.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15969  36 FYLKNIVIADLLMTLTFPFKIIQDSGLGPWNfnfFLCRYTSVLFYASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITF 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSD------DTWSAKVFFpLEVFGFLLPMGIMGFC-CSRSIHILLG 210
Cdd:cd15969 116 TKVLSACVWLIMAFLSLPNIILTNGQPTEDNIHDCSKlksplgVKWHTAVSY-INICIFVAVLVILIVCyISISRYIYKS 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 211 RRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYF 290
Cdd:cd15969 195 SKQFISSSSRTRKHNQSIRVVVAVFFVCFLPYHLCRIPFTFSQLDKILDCTIKTILYYCKEATLFLSACNVCLDPIIYFF 274

                ....*
gi 33695107 291 VIKEF 295
Cdd:cd15969 275 MCRSF 279
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
58-197 9.23e-08

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 52.72  E-value: 9.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLL-LVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLvSHLR 133
Cdd:cd15134  34 ATNYYLFSLAVSDLLlLILGLPFELYTIWQQYPWVfgeVFCKLRAFLSEMSSYASVLTITAFSVERYLAICHPLR-SHTM 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 S--PRKIFGICCtIWVLVWTGSIPI-------YSFHGKV------EKYMCfhNMSDDTWSAKVFFPLEVF-GFLLPMGIM 197
Cdd:cd15134 113 SklSRAIRIIIA-IWIIAFVCALPFaiqtrivYLEYPPTsgealeESAFC--AMLNEIPPITPVFQLSTFlFFIIPMIAI 189
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
61-296 1.05e-07

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 52.10  E-value: 1.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSlCTLVECL-YFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIF 139
Cdd:cd15163  37 IYTINLVVTDLLVGLSLPTRIVMYYSAGNCLT-CSFVHIFsYFVNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAK 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 140 GICCTIWVLVWTGSIPIYSFHGKVEKYMCFHnmsddtwsakvFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWV 219
Cdd:cd15163 116 GICVFIWLFAIVVTFSILTTAIKFASCCLSK-----------LFALTVFEFFLPLLIITFFTIRIMCALSRPGLMHQSRE 184
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33695107 220 QQKACIYSIAASLAVFVVSFLPVHLGFFLQFlvrnsFIVECRAKQSISFFlQLSMCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15163 185 RRMRAVQLLITVLIIFMICFTPFHVRQVAVA-----FNPDIPHHTSLIVY-HVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
61-296 1.15e-07

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 52.06  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFkmVLSQVQSP---FPSL-CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPlLVSHLRSPR 136
Cdd:cd14999  36 VYILNLALADLLYLLTIPF--YVSTYFLKkwyFGDVgCRLLFSLDFLTMHASIFTLTVMSTERYLAVVKP-LDTVKRSKS 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSD---DTWSA---KVFFP-LEVFGFLLPMGIMGFCCSRSIHILL 209
Cdd:cd14999 113 YRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSKRiclPTWSEesyKVYLTlLFSTSIVIPGLVIGYLYIRLARKYW 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 -----GRRDHTQDWVQQKAcIYSIAASLAVFVVSFLPVhLGFFLQFLVRNSFIVECRAKQSISFFLQlsmCFSNVNCCLD 284
Cdd:cd14999 193 lsqaaASNSSRKRLPKQKV-LKMIFTIVLVFWACFLPF-WIWQLLYLYSPSLSLSPRTTTYVNYLLT---CLTYSNSCIN 267
                       250
                ....*....|..
gi 33695107 285 VFCYYFVIKEFR 296
Cdd:cd14999 268 PFLYTLLTKNYK 279
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
59-297 1.34e-07

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 51.91  E-value: 1.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLL-VLSLPFKMVLSqVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLvsHLRS 134
Cdd:cd15390  35 TNYFLVNLAVADLLIsAFNTVFNFTYL-LYNDWPfglFYCKFSNFVAITTVAASVFTLMAISIDRYIAIVHPLR--PRLS 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPiYSFHGKVEKY---------MCF------HNMSDDTWSAKVFFPLEVFgflLPMGIMGF 199
Cdd:cd15390 112 RRTTKIAIAVIWLASFLLALP-QLLYSTTETYyyytgsertVCFiawpdgPNSLQDFVYNIVLFVVTYF---LPLIIMAV 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 200 CCSRSIHILLGRR---DHTQDWVQQ----KACIYSIAASLAVFVVSFLPVHLGFFLQFLvrNSFIVECRAKQSI---SFF 269
Cdd:cd15390 188 AYTRVGVELWGSKtigENTPRQLESvrakRKVVKMMIVVVVIFAICWLPYHLYFILTYL--YPDINSWKYIQQIylaIYW 265
                       250       260
                ....*....|....*....|....*...
gi 33695107 270 LQLSmcfsnvNCCLDVFCYYFVIKEFRM 297
Cdd:cd15390 266 LAMS------NSMYNPIIYCWMNKRFRY 287
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
61-161 1.38e-07

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 52.12  E-value: 1.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPF---KMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15338  40 IFIFNLSIVDLLFLLGMPFlihQLLGNGVWHFGETMCTLITALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRV 119
                        90       100
                ....*....|....*....|....
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHG 161
Cdd:cd15338 120 AVAVICLVWILSLLSITPVWMYAG 143
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
58-241 1.78e-07

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 51.52  E-value: 1.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVL-SLPFKMVLSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd14997  34 PTNIFLVNLSVADLLVLLvCMPVALVETWAREPWllgEFMCKLVPFVELTVAHASVLTILAISFERYYAICHPLQAKYVC 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIPIYSFhgkVEKYMCFHNM----------SDDTWSAKVFFPLEVFGFLLPMGIMGFCCSR 203
Cdd:cd14997 114 TKRRALVIIALIWLLALLTSSPVLFI---TEFKEEDFNDgtpvavcrtpADTFWKVAYILSTIVVFFVVPLAILSGLYSV 190
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 33695107 204 SIHILLGRRDHTQDWVQQKA---------CIYSIAASLAVFVVSFLP 241
Cdd:cd14997 191 ICRRLVGHPALESRRADAANrhtlrsrrqVVYMLITVVVLFFVCLLP 237
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
61-296 1.79e-07

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 51.68  E-value: 1.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15924  36 IYLKNTVVADLLMILTFPFKILSDAGLGPWQlrtFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSF 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIP-IYSFHGKVEKYMCFHNMSDDT----WSAKVFFPLEVFGFLLPMGIMGFC---CSRSIHILL 209
Cdd:cd15924 116 AKILSVVVWALMFLLSLPnMILTNQQPREKNVKKCSFLKSelglKWHEIVNYICQVIFWIVFLLMIVCytaITKKVYRSY 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 GRRDHTQDWVQQKACIySIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYY 289
Cdd:cd15924 196 RRVFRSSSSRRKKSNV-KIFIIVAVFFVCFVPYHFARIPYTLSQTRDVFDCTAENILFYVKEATLFLSALNVCLDPIIYF 274

                ....*..
gi 33695107 290 FVIKEFR 296
Cdd:cd15924 275 FLCKSFR 281
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
42-203 1.89e-07

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 51.42  E-value: 1.89e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  42 IHGFSTFLKNRWPdyaaTSIYMINLAVFDLLLVLSLPFKMVLSQVQSPF--PSLCTLVECLYFVSMYGSVFTICFISMDR 119
Cdd:cd15079  22 IYIFSTTKSLRTP----SNMLVVNLAISDFLMMIKMPIFIYNSFYEGWAlgPLGCQIYAFLGSLSGIGSIWTNAAIAYDR 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 120 FLAIRYPLLVSHLrSPRKIFGICCTIWvlVWTGSIPIYSFHGKVEKYM-------CFHNMSDDTWSAKVF-FPLEVFGFL 191
Cdd:cd15079  98 YNVIVKPLNGNPL-TRGKALLLILFIW--LYALPWALLPLLFGWGRYVpegfltsCSFDYLTRDWNTRSFvATIFVFAYV 174
                       170
                ....*....|..
gi 33695107 192 LPMGIMGFCCSR 203
Cdd:cd15079 175 IPLIIIIYCYSF 186
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
28-296 2.40e-07

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 51.39  E-value: 2.40e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  28 IPTFVLGLLLNLLAIHGFSTFLKNRWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVS 104
Cdd:cd15149   3 IPVFYSLVFIVGILLNGVNFWIFFYVPSNKSFIVYLKNIVFADLLMSLTFPFKILSDVELGPWQlnvIVCRYSAVIFYLN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 105 MYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIY-----SFHGKVEKyMCFHNMSD--DTW 177
Cdd:cd15149  83 MYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIiltnqSFHEANYT-KCARLKSElgIQW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 178 ---SAKVFFPLEVFGFLLpMGIMGFCCSRSIH--ILLGRRDHTQDWVQQKACIYSIaasLAVFVVSFLPVHLGFFLQFLV 252
Cdd:cd15149 162 hkaSNYICVSIFWVVFLL-LIIFYVAISRKIYksNQKFRRNSTNMKAKSSRNIFSI---LFVFFVCFVPYHALRIPYTLS 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 33695107 253 RNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15149 238 QTGADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFR 281
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
59-296 3.38e-07

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 50.90  E-value: 3.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKM--VLSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15119  34 NTLWFLNLAIADFVFVLFLPLHItyVALDFHWPFgVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRYRTL 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSFHGKVEK-------YMCFHNMSDDTWSAKVFFPLEV---FGFLLPMGIMGFCcsrsi 205
Cdd:cd15119 114 KSALILCGIVWLSAAAISGPALYFRDTMELsinvticFNNFHKHDGDLIVMRHTILVWVrffFGFLFPLLTMVVC----- 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 206 HILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSfiVECRAKQSISFFLQLSMCFsnVNCCLDV 285
Cdd:cd15119 189 YSLLAIKVKRRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILELSIHHS--SYLHNVLRAGIPLATSLAF--INSCLNP 264
                       250
                ....*....|.
gi 33695107 286 FCYYFVIKEFR 296
Cdd:cd15119 265 ILYVLIGKKFK 275
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
59-296 3.42e-07

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 50.44  E-value: 3.42e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLL-VLSLPFKMVLSQVQS-PFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15061  34 TNCYIVSLATADLLVgVLVLPLAIIRQLLGYwPLGShLCDFWISLDVLLCTASILNLCCISLDRYFAITYPLKYRTKRSR 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIP---IYSFHGKVEKYMCFHNMSddtwSAKVFFPlEVFGFLLPMGIMGFCCSRSIHILLGRR 212
Cdd:cd15061 114 RLAITMILAVWVISLLITSPplvGPSWHGRRGLGSCYYTYD----KGYRIYS-SMGSFFLPLLLMLFVYLRIFRVIAKER 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 213 DHTQdwvqqkaciySIAASLAVFVVSFLPvhlgFFLQFLVRNsfIVECRAKQSIS-FFLQLSMCFSNVNccldVFCYYFV 291
Cdd:cd15061 189 KTAK----------TLAIVVGCFIVCWLP----FFIMYLIEP--FCDCQFSEALStAFTWLGYFNSVIN----PFIYAFY 248

                ....*
gi 33695107 292 IKEFR 296
Cdd:cd15061 249 NKDFR 253
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
58-252 3.47e-07

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 50.77  E-value: 3.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKMV--LSQVQSPFP-SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15052  34 VTNYFLMSLAIADLLVgLLVMPLSILteLFGGVWPLPlVLCLLWVTLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNK 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAKVFFPlEVFGFLLPMGIMGFCCSRSIHILLGRRD 213
Cdd:cd15052 114 SRTTVFLKIAIVWLISIGISSPIPVLGIIDTTNVLNNGTCVLFNPNFVIYG-SIVAFFIPLLIMVVTYALTIRLLSNEQK 192
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 33695107 214 HTQdwvqqkaciySIAASLAVFVVSFLPVhlgFFLQFLV 252
Cdd:cd15052 193 ASK----------VLGIVFAVFVICWCPF---FITNILT 218
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
58-296 4.24e-07

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 50.44  E-value: 4.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKMV--LSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPlLVSHLR 133
Cdd:cd15392  34 VTNYFIVNLALSDILMaVFCVPFSFIalLILQYWPFgEFMCPVVNYLQAVSVFVSAFTLVAISIDRYVAIMWP-LRPRMT 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGICCtIWVLVWTGSIPIYSF-------HGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIH 206
Cdd:cd15392 113 KRQALLLIAV-IWIFALATALPIAITsrlfedsNASCGQYICTESWPSDTNRYIYSLVLMILQYFVPLAVLVFTYTRIGI 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 207 ILLGRR-------DHTQDWVQQKA-CIYSIAASLAVFVVSFLPVHlgFFLQFLVRNSFIVECRAKQSISFFLQ-LSMCfs 277
Cdd:cd15392 192 VVWAKRtpgeaenNRDQRMAESKRkLVKMMITVVAIFALCWLPLN--ILNLVGDHDESIYSWPYIPYLWLAAHwLAMS-- 267
                       250
                ....*....|....*....
gi 33695107 278 nvNCCLDVFCYYFVIKEFR 296
Cdd:cd15392 268 --HCCYNPFIYCWMNAKFR 284
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
61-296 4.60e-07

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 50.58  E-value: 4.60e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15150  36 IFLKNTVISDLLMILTFPFKILSDAKLGSWPlrgFVCQVTSVIFYFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLG 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHGKV----EKYMCFHNMSDD--TWSAKVFFPLEVFgFLLPMGIMGFCCSRSIHILLG- 210
Cdd:cd15150 116 AKILSTVIWASMFALSLPNMILTNRQptpkNVKKCSLLKSEFglVWHEIVNYICQVI-FWVNFLIVIVCYTLITKELYKs 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 211 -RRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYY 289
Cdd:cd15150 195 yKRTRGVGKVSRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAKNTLFYVKESTLWLTSLNACLDPFIYF 274

                ....*..
gi 33695107 290 FVIKEFR 296
Cdd:cd15150 275 FLCKSFR 281
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
58-296 4.75e-07

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 50.32  E-value: 4.75e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKMVLS-QVQSPFPSlCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15069  34 PTNYFLVSLAAADVAVgLFAIPFAITISlGFCTDFHS-CLFLACFVLVLTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTG 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVW-TGSIPIYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGF-----CCSRSIHILL 209
Cdd:cd15069 113 KRARGVIAVLWVLAFgIGLTPFLGWNKAMSATNNSTNPADHGTNHSCCLISCLFENVVPMSYMVYfnffgCVLPPLLIML 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 G-----------------RRDHTQDWVQQKA-CIYSIAASLAVFVVSFLPVHLgfflqfLVRNSFIVECRAKQSISFFLQ 271
Cdd:cd15069 193 ViyikiflvacrqlqrteLMDHSRTTLQREIhAAKSLAIIVGIFALCWLPVHI------LNCITLFQPEFSKSKPKWAMN 266
                       250       260
                ....*....|....*....|....*
gi 33695107 272 LSMCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15069 267 VAILLSHANSVVNPIVYAYRNRDFR 291
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
61-296 5.77e-07

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 49.96  E-value: 5.77e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVL-SLPF-KMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15927  37 IFILSLALGDLLLLLtCVPFtSTIYTLDSWPFGEfLCKLSEFLKDTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRR 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIP------IYSFHGKVEKYMCF---HNMSDDTWSAKVFFPLE--VFgFLLPMGIMG-FCCSRSI 205
Cdd:cd15927 117 TLVTAASIWIVSILLAIPeaifshVVTFTLTDNQTIQIcypYPQELGPNYPKIMVLLRflVY-YLIPLLIIGvFYVLMAR 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 206 HILLGRRDHT-QDWVQQKACIYS-------IAASLAVFVVSFLPVHLgFFLQFlvrnSFIVEcrAKQSISFFLQ----LS 273
Cdd:cd15927 196 HLIRSTRNIGsGQNQAAQRQIEArkkvaktVLAFVVLFAVCWLPRHV-FMLWF----HFAPN--GLVDYNAFWHvlkiVG 268
                       250       260
                ....*....|....*....|...
gi 33695107 274 MCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15927 269 FCLSFINSCVNPVALYLLSGSFR 291
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
61-296 6.99e-07

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 49.78  E-value: 6.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15151  36 VYLKNTLVADLIMTLMLPFKILSDSGLGPWqlrAFVCRFSAVVFYITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRF 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHGK------VEKYMCFHNMSDDTWSAKVFFPLEV--FGFLLPMGIMGFCCSRSIHILL 209
Cdd:cd15151 116 AKILSGAVWLVMFLLSVPNMILSNKpatpisVKKCASLKSPLGLKWHEVVNYICQFifWGVFALMVLFYTIISKKVYESY 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 gRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYY 289
Cdd:cd15151 196 -KKSRSKDNKASKKTKAKVFIIVAVFFVCFAPFHFVRVPYTLSQTGKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYI 274

                ....*..
gi 33695107 290 FVIKEFR 296
Cdd:cd15151 275 FLCKSFR 281
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
59-255 9.44e-07

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 49.41  E-value: 9.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLVECLYFVS---MYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15928  35 TNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSetcTYASILHITALSVERYLAICHPLRAKVLVTR 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSFHGkVEkymcfHNMSDDT--------------------WSAKVFFPLEVFGFLLPMG 195
Cdd:cd15928 115 GRVKLLIAVIWAVAIVSAGPALVLVG-VE-----HIQGQQTprgfectvvnvssgllsvmlWVSTSFFFVPMVCLSLLYG 188
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 196 IMGFCCSRSIHILLGRRDHTQDwVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNS 255
Cdd:cd15928 189 LIGRALWDRRQRSRTAGASRRD-NNHRQTVRMLAVIVLAFVLCWLPFHVGRVIFNHSRAS 247
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
63-243 1.12e-06

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 49.33  E-value: 1.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  63 MINLAVFDLLLVL-SLPFKMV-LSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPlLVSHLRSPRKIF 139
Cdd:cd15002  40 ILNLSAADLLLLLfSVPFRAAaYSKGSWPLGWfVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNP-TKQVTIKQRRIT 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 140 GICCTIWVLVWTGSIPIYSF------HGKVEKYMCFHNMSDDTWSAKV-FFPLevFGFLLPMGIMGFCCSRSIHILLGRR 212
Cdd:cd15002 119 AVVASIWVPACLLPLPQWLFrtvkqsEGVYLCILCIPPLAHEFMSAFVkLYPL--FVFCLPLTFALFYFWRAYGQCQRRG 196
                       170       180       190
                ....*....|....*....|....*....|....
gi 33695107 213 DHTQDWVQQ--KACIYSIAASLAV-FVVSFLPVH 243
Cdd:cd15002 197 TKTQNLRNQirSRKLTHMLLSVVLaFTILWLPEW 230
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
59-244 1.27e-06

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 49.31  E-value: 1.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVL-SLPFKMVLSQVQSPF--PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLV--SHLR 133
Cdd:cd15208  35 TNYFIVNLSLADFLVIIiCLPATLLVDVTETWFfgQVLCKIIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFksTAKR 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGicctIWVLVWTGSIP------IYSFHGKVEKY----MCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSR 203
Cdd:cd15208 115 ARVSILI----IWIVSLLIMIPqaivmeCSRVVPLANKTilltVCDERWSDSIYQKVYHICFFLVTYLLPLCLMILAYFQ 190
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33695107 204 SIHILLGRRDHTQDWVQQKACIYSIAAS---------------------LAVFVVSFLPVHL 244
Cdd:cd15208 191 IFRKLWCRQIPGTSSVVQRKWNKPRKSAvaaeekqlrsrrktakmlivvVIMFAICYLPVHL 252
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
59-203 1.44e-06

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 48.94  E-value: 1.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLL-VLSLPFKMVLSQVQS-PFP-SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15393  35 TNIFIANLAVADIIIgLFSIPFQFQAALLQRwVLPrFMCPFCPFVQVLSVNVSVFTLTVIAVDRYRAVIHPLKARCSKKS 114
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33695107 136 RKIfgICCTIWVLVWTGSIPIYSFH---------GKVEKYMCF-HNMSDDTWSAKVFFpLEVFGFLLPMGIMGFCCSR 203
Cdd:cd15393 115 AKI--IILIIWILALLVALPVALALrveeltdktNNGVKPFCLpVGPSDDWWKIYNLY-LVCVQYFVPLVIICYAYTR 189
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
48-252 2.93e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 47.75  E-value: 2.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  48 FLKNRWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS---LCTLVECLYFVSMYGSVFTICFISMDRFLAIR 124
Cdd:cd15104  24 LLKLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTqkvLCLLRMCFVITSCAASVLSLAAIAFDRYLALK 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 125 YPLLVSHLRSPRKIFGICCTIWVL-VWTGSIP--IYSFHGKVEKYMC-----FHNMSDDTWSAKVFFP--LEVFGFLLPM 194
Cdd:cd15104 104 QPLRYKQIMTGKSAGALIAGLWLYsGLIGFLPliSPQFQQTSYKGKCsffaaFHPRVLLVLSCMVFFPalLLFVFCYCDI 183
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33695107 195 GIMGFCCSRSI----HILLGRRDHTQDWVQQKAciysiAASLAVFVVSFLPVHLGFFLQFLV 252
Cdd:cd15104 184 LKIARVHSRAIykveHALARQIHPRRTLSDFKA-----ARTVAVLIGCFLLSWLPFQITGLV 240
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
60-249 2.99e-06

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 47.89  E-value: 2.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLL-VLSLPFKMVLSQVQS-PFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15391  36 NYYLINLAVSDLIMaLFCMPFTFTQIMLGHwVFPApMCPIVLYVQLVSVTASVLTNTAIGIDRFFAVIFPLRSRHTKSRT 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 137 KIfgICCTIWVLVWTGSiPIYSFHGKVEKYMCFHNMS---------DDTWSAKVFFPLEVFGFLLPMGIMgfccsRSIHI 207
Cdd:cd15391 116 KC--IIASIWAISFSLS-SVQLFAGRTQRYGQYSEGRvlcgeswpgPDTSRSAYTVFVMLLTYIIPLLIL-----TSTYG 187
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 33695107 208 LLGRR----------DHTQDWVQ---QKACIYSIAASLAVFVVSFLPVHLGFFLQ 249
Cdd:cd15391 188 YVGFRlwnrtapgnaDKGRDDMQiksKRKVIKMLVFVVLMFGICWLPLHLFNLVQ 242
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
60-149 4.19e-06

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 47.68  E-value: 4.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLL-VLSLPFKMVLSqVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15048  36 NFFLLNLAVADFLVgLVSMPFYIPYT-LTGKWPfgkVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTK 114
                        90
                ....*....|....
gi 33695107 136 RKIFGICCTIWVLV 149
Cdd:cd15048 115 RRTVLLMALVWILA 128
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
49-278 4.38e-06

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 47.42  E-value: 4.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  49 LKNRWPDYAATSIYMINLAVFDLLLVLSLP---FKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRY 125
Cdd:cd14964  23 LVRLRKRPRSTRLLLASLAACDLLASLVVLvlfFLLGLTEASSRPQALCYLIYLLWYGANLASIWTTLVLTYHRYFALCG 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 126 PLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKvekymcFHNMSDDTWSAKVFFPLEV-------FGFLLPMGIMG 198
Cdd:cd14964 103 PLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGA------IPRYNTLTGSCYLICTTIYltwgfllVSFLLPLVAFL 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 199 FCCSRSIHiLLGRRDHTQDWVQQKACIYSIAAS------LAVFVVSFLPVHLGFFLQFLVRNSFIVEcrAKQSISFFLQL 272
Cdd:cd14964 177 VIFSRIVL-RLRRRVRAIRSAASLNTDKNLKATksllilVITFLLCWLPFSIVFILHALVAAGQGLN--LLSILANLLAV 253

                ....*.
gi 33695107 273 SMCFSN 278
Cdd:cd14964 254 LASTLN 259
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
41-200 6.99e-06

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 46.94  E-value: 6.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  41 AIHGFSTFLKNRWPDYaatsIYMINLAVFDLLL-VLSLPFkMVLSQV--QSPF-PSLCTLVEclYFVSMYG--SVFTICF 114
Cdd:cd15083  21 VIYAFCRFKSLRTPAN----YLIINLAISDFLMcILNCPL-MVISSFsgRWIFgKTGCDMYG--FSGGLFGimSINTLAA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 115 ISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWV--LVWTgSIPIYSFHGKV-EKYMC---FHNMSDDTWSAKVFFPLEVF 188
Cdd:cd15083  94 IAVDRYLVITRPMKASVRISHRRALIVIAVVWLysLLWV-LPPLFGWSRYVlEGLLTscsFDYLSRDDANRSYVICLLIF 172
                       170
                ....*....|..
gi 33695107 189 GFLLPMGIMGFC 200
Cdd:cd15083 173 GFVLPLLIIIYC 184
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
59-197 7.25e-06

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 46.78  E-value: 7.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLL-LVLSLPFKMVLSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15357  35 TNYYLFSLAVSDLLvLLFGMPLEVYEMWSNYPFlfgPVGCYFKTALFETVCFASILSVTTVSVERYVAILHPFRAKLNST 114
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGF----------LLPMGIM 197
Cdd:cd15357 115 RERALKIIVVLWVLSVLFSIPNTSIHGIKLQYFPNGTLIPDSATCTVVKPLWIYNLiiqitsllfyVLPMGVI 187
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
58-159 8.16e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 46.46  E-value: 8.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKM--VLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15304  34 ATNYFLMSLAIADMLLgFLVMPVSMltILYGYRWPLPSkLCAVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFN 113
                        90       100
                ....*....|....*....|....*.
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIPIYSF 159
Cdd:cd15304 114 SRTKAFLKIIAVWTISVGISMPIPVF 139
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
59-263 8.24e-06

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 46.50  E-value: 8.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLL-VLSLPFKM----VLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPllvshlR 133
Cdd:cd15204  35 TNLLIANLALSDFLVaVFCLPFEMdyyvVRQRSWTHGDVLCAVVNYLRTVSLYVSTNALLVIAIDRYLVIVHP------L 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGICCTIWVLVWTGS----IP--IYSfhgKVEKYMCFHNM-------SDDTWSAKVFFpLEVFG--FLLPMGIMG 198
Cdd:cd15204 109 KPRMKRRTACVVIALVWVVSlllaIPsaVYS---KTTPYANQGKIfcgqiwpVDQQAYYKAYY-LFLFVleFVLPVLIMT 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 199 FCCSR-SIHI----LLGRRDHTQDWVQQ--KACIYSIAASLAVFVVSFLPVHL-----GFFLQFLVRNS------FIVEC 260
Cdd:cd15204 185 LCYLRiVRKVwfrrVPGQQTEQIRRRLRrrRRKVRLLVVILTAFVLCWAPYYGyaivrDFFPTLLSKEKlnttifYIVEA 264

                ...
gi 33695107 261 RAK 263
Cdd:cd15204 265 LAM 267
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
59-156 8.37e-06

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 46.92  E-value: 8.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLL-VLSLPFKMVlSQVQS--PFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15320  37 TNFFVISLAVSDLLVaVLVMPWKAV-AEIAGfwPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTP 115
                        90       100
                ....*....|....*....|..
gi 33695107 136 RKIFGICCTIWVL-VWTGSIPI 156
Cdd:cd15320 116 KVAFIMISVAWTLsVLISFIPV 137
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
59-156 1.51e-05

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 45.71  E-value: 1.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLL-VLSLPFK-MVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15307  35 TNYFLMSLAITDLMVaVLVMPLGiLTLVKGHFPLSSeHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTR 114
                        90       100
                ....*....|....*....|.
gi 33695107 136 RKIFGICCTIWVLVWTGSIPI 156
Cdd:cd15307 115 RRVTLKIVFVWLLSIAMSLPL 135
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
57-280 1.59e-05

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 45.70  E-value: 1.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  57 AATSIYMINLAVFDLLL-VLSLPFKMVLSQVQSPF--PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15323  33 APQNLFLVSLASADILVaTLVMPFSLANELMGYWYfgQVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKR 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGICCTIWVLVWTGSI-PIYSFHGKVE---KYMCfhNMSDDTWsakvffplevfgFLLPMGIMGFCCSRSIHILL 209
Cdd:cd15323 113 TPRRVKAIIVTVWLISAVISFpPLISMYRDPEgdvYPQC--KLNDETW------------YILSSCIGSFFAPCLIMILV 178
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33695107 210 GRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSfiveCRAKQSI-SFFLQLSMCFSNVN 280
Cdd:cd15323 179 YIRIYRVAKAREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGICREA----CEVPEPLfKFFFWIGYCNSSLN 246
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
58-296 2.16e-05

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 45.19  E-value: 2.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKMVLSQVQS-PFP-SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15202  34 VTNYFIVNLAVADIMItLFNTPFTFVRAVNNTwIFGlFMCHFSNFAQYCSVHVSAYTLTAIAVDRYQAIMHPLKPRISKT 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIfgICCTIWVLVWTGSIP--------IYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFG--FLLPMGIMGFC---- 200
Cdd:cd15202 114 KAKF--IIAVIWTLALAFALPhaicskleTFKYSEDIVRSLCLEDWPERADLFWKYYDLALFIlqYFLPLLVISFAyarv 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 201 -----CSRSIHILLGRRDHTQDWVQQKAcIYSIAASLAVFVVSFLPVHlgffLQFLVRNSFivECRAKQSISFFLQLSMC 275
Cdd:cd15202 192 giklwASNMPGDATTERYFALRRKKKKV-IKMLMVVVVLFALCWLPFN----IYVLLLSSK--PDYLIKTINAVYFAFHW 264
                       250       260
                ....*....|....*....|.
gi 33695107 276 FSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15202 265 LAMSSTCYNPFIYCWLNERFR 285
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
61-296 2.68e-05

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 44.82  E-value: 2.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPF-KMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIF 139
Cdd:cd15171  37 IYFLNLAVSNLCFLLTLPFwAHAAWHGGSLGNPTCKVLVALSSVGLHSEALFNVLLTVQASRVFFHGRLASSARRVAPCG 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 140 GICCTI-WVLVWTGSIP---IYSFHGKVEKYMCF----HNMSDDTWSAKVFFPLE--VFGFLLPMGIMGFCCsrsihilL 209
Cdd:cd15171 117 IIASVLaWLTAFLVTLPefvFYKPQMDSQKSKCAfsrpHFLPAEETFWKYFLTLKmnIVVLVFPLLVFIICC-------V 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 GRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYY 289
Cdd:cd15171 190 QLRKTQRFRERQRDLSKLVFAIMVVFLLMWAPYNIALFLSAFKEHFSLRDCKSSYHLDASVQVTKLIATTHCCVNPLLYA 269

                ....*..
gi 33695107 290 FVIKEFR 296
Cdd:cd15171 270 LLDPAFR 276
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
61-296 2.91e-05

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 44.80  E-value: 2.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKM--VLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15339  36 IYVCNLAVADLVHIIVMPFLIhqWARGGEWVFGSpLCTIITSLDTCNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSK 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYsFHGKVEKY-----MCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCS-------RSI 205
Cdd:cd15339 116 TIRINLLVWAASFILVLPVW-VYAKVIKFrdgleSCAFNLTSPDDVLWYTLYQTITTFFFPLPLILICYIlilcytwEMY 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 206 HILLGRRDHTQDWVQQKACIYS--IAASLAVFVVSFLPVHLGFFLQFLVRNSfivecrakqSISFFL--QLSMCFSNVNC 281
Cdd:cd15339 195 RKNKKAGRYNTSIPRQRVMRLTkmVLVLVGVFLVSAAPYHVIQLVNLSVSQP---------TLAFYVsyYLSICLSYASS 265
                       250
                ....*....|....*
gi 33695107 282 CLDVFCYYFVIKEFR 296
Cdd:cd15339 266 SINPFLYILLSGNFR 280
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
56-155 4.40e-05

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 44.25  E-value: 4.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  56 YAATSIYMINLAVFDLLLV-LSLPFKMVlSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPlLVSH 131
Cdd:cd15389  32 HTATNLFIVNLAVSDILITlLNTPFTLV-RFVNSTWVfgkIMCHLSRFAQYCSVYVSTLTLTAIALDRHRVILHP-LKPR 109
                        90       100
                ....*....|....*....|....
gi 33695107 132 LRSPRKIFGICCtIWVLVWTGSIP 155
Cdd:cd15389 110 ITPCQGVVVIAI-IWIMASCLSLP 132
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
60-220 5.57e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 44.23  E-value: 5.57e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLL--LVLSLPFKMVLSQVQS-PFPSL-CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15337  36 NMFIINLAISDFGfsAVNGFPLKTISSFNKKwIWGKVaCELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTF 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWV--LVWTGSiPIYSFHGKV-EKYMC---FHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRsihILL 209
Cdd:cd15337 116 KRAFIMIIIIWLwsLLWSIP-PFFGWGRYVpEGFQTsctFDYLSRDLNNRLFILGLFIFGFLCPLLIIIFCYVN---IIR 191
                       170
                ....*....|.
gi 33695107 210 GRRDHTQDWVQ 220
Cdd:cd15337 192 AVRNHEKEMTQ 202
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
58-156 6.60e-05

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 43.74  E-value: 6.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLL---LVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15305  34 ATNFFLMSLAVADMLvgiLVMPVSLIAILYDYAWPLPRyLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFN 113
                        90       100
                ....*....|....*....|...
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIPI 156
Cdd:cd15305 114 SRTKAMMKIAAVWTISIGISMPI 136
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
45-158 7.12e-05

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 44.03  E-value: 7.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107   45 FSTFLKNRWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQ-VQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAI 123
Cdd:PHA03235  55 VTQLLANRVHGFSTPTLYMTNLYLANLLTVFVLPFIMLSNQgLLSGSVAGCKFASLLYYASCTVGFATVALIAADRYRVI 134
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 33695107  124 --RYPLLVSHLRSPRKIFGIcctIWV--LVWTGSIPIYS 158
Cdd:PHA03235 135 hqRTRARSSAYRSTYKILGL---TWFasLICSGPAPVYT 170
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
58-208 8.61e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 43.39  E-value: 8.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLL-LVLSLPFKMVLS--QVQSPFPSLCTLVECLYF-----VSMYGSVFTICFISMDRFLAIRYPLLV 129
Cdd:cd14978  33 STNVYLAALAVSDILvLLSALPLFLLPYiaDYSSSFLSYFYAYFLPYIyplanTFQTASVWLTVALTVERYIAVCHPLKA 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 130 SHLRSPRKIFGICCTIWVLVWTGSIPIY-----------SFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMG 198
Cdd:cd14978 113 RTWCTPRRARRVILIIIIFSLLLNLPRFfeyevvecencNNNSYYYVIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLL 192
                       170
                ....*....|
gi 33695107 199 FCCSRSIHIL 208
Cdd:cd14978 193 ILNILLIRAL 202
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
48-290 9.73e-05

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 43.22  E-value: 9.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  48 FLKNRWPdyaATSIYMINLAVFDLLLVLSLPFKM---VLSQVQSPFPSLCTLveCLYFVSM--YGSVFTICFISMDRFLA 122
Cdd:cd15200  27 FHRRPWK---SNTMYLLSLVVADFFLIINLPFRIdyyLRNEVWRFGATACQV--NLFMLSMnrTASIVFLTAIALNRYLK 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 123 IRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMC--FHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFC 200
Cdd:cd15200 102 VVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLLLLDHVQSNSTClsYDHGTDPSASDRWHRILFFLEFFLPLGIILFC 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 201 CSRSIHILLGRRDHTQDWVQQKACIysIAASLAVFVVSFLPVHLgFFLQFLVRNSfIVECRAKQSISFFLQLSMCFSNVN 280
Cdd:cd15200 182 IFSIILTLKQRKLAKQAGPQRAVKV--LAVIVLVYTVCFLPSIL-FALASLVAFK-VSQCRSLDLCTQLFHGSLAFTYLN 257
                       250
                ....*....|
gi 33695107 281 CCLDVFCYYF 290
Cdd:cd15200 258 SALDPVLYCF 267
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
58-147 1.00e-04

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 43.09  E-value: 1.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKMVLsQVQSPFPslCTLVECLYFVSM-----YGSVFTICFISMDRFLAIRYPLLVSH 131
Cdd:cd15051  34 LTNYFIVSLAVTDLLLgLLVLPFSAIY-ELRGEWP--LGPVFCNIYISLdvmlcTASILNLFAISLDRYLAITAPLRYPS 110
                        90
                ....*....|....*.
gi 33695107 132 LRSPRKIFGICCTIWV 147
Cdd:cd15051 111 RVTPRRVAIALAAIWV 126
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
58-296 1.10e-04

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 43.02  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKMV--LSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15210  34 RTNAFIINLSISDLLFcAFNLPLAAStfLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYT 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 135 PRKIFGICCTIWVL-------VWTGSIPIYSFHGKVekYMC-FHNMSDDTWSAKVFFpleVFGFLLPMGIMGFCCSRsih 206
Cdd:cd15210 114 RRGLALMIAGTWIFsfgsflpLWLGIWGRFGLDPKV--CSCsILRDKKGRSPKTFLF---VFGFVLPCLVIIICYAR--- 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 207 illgrrdhTQDWVQQKACIysiaASLAVFVVSFLPvhlgfflqFLVRNSFivecRAKQSISFFLQLSMCFSNVNCCLDVF 286
Cdd:cd15210 186 --------REDRRLTRMML----VIFLCFLVCYLP--------ITLVNVF----DDEVAPPVLHIIAYVLIWLSSCINPI 241
                       250
                ....*....|
gi 33695107 287 CYYFVIKEFR 296
Cdd:cd15210 242 IYVAMNRQYR 251
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
59-154 1.44e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 42.48  E-value: 1.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLL-VLSLPFKMVLSQVQSPF--PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15062  35 THYFIVNLAVADLLLsFTVLPFSATLEVLGYWAfgRIFCDVWAAVDVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTA 114
                        90
                ....*....|....*....
gi 33695107 136 RKIFGICCTIWVLVWTGSI 154
Cdd:cd15062 115 RRATVALLIVWVLSLVISI 133
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
58-203 1.61e-04

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 42.58  E-value: 1.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLsLPFKMVLSQVQSPFPSL----CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15402  34 AGNIFVVSLAVADLVVAI-YPYPLVLTSIFHNGWNLgylhCQISGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLY 112
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIP---IYSFHGKVEKYMC-FHNMSDDTWSAKVFFplevFGFLLPMGIMGFCCSR 203
Cdd:cd15402 113 SDKNSLCYVLLIWVLTVAAIVPnlfVGSLQYDPRIYSCtFAQSVSSAYTIAVVF----FHFILPIIIVTFCYLR 182
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
59-248 1.88e-04

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 42.56  E-value: 1.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLVECLYFVS---MYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15131  35 TNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSescTYSTILNITALSVERYFAICFPLRAKVVVTK 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSFHG---------------KVEKYMCFHNM-SDDTWSAKVFFPLEVFGFLLPMGIMGF 199
Cdd:cd15131 115 RRVKLVILVLWAVSFLSAGPIFVLVGvehengtnpidtnecKATEYAVRSGLlTIMVWVSSVFFFLPVFCLTVLYSLIGR 194
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 33695107 200 CCSRSIHILLGRRDHTQDwVQQKACIYSIAASLAVFVVSFLPVHLGFFL 248
Cdd:cd15131 195 KLWRRRRENIGPNASHRD-KNNRQTVKMLAVVVFAFVLCWLPFHVGRYL 242
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
61-200 2.44e-04

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 41.98  E-value: 2.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLslpFKMVLSQVQSPF------PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLlvSHLRS 134
Cdd:cd14986  37 IFILNLAIADLVVAF---FTVLTQIIWEATgewvagDVLCRIVKYLQVVGLFASTYILVSMSLDRYQAIVKPM--SSLKP 111
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPIYSFHGKVEK----YMCFHNMSDDtWSAKVFFP-LEVFGFLLPMGIMGFC 200
Cdd:cd14986 112 RKRARLMIVVAWVLSFLFSIPQLVIFVERELgdgvHQCWSSFYTP-WQRKVYITwLATYVFVIPLIILSYC 181
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
59-296 2.61e-04

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 41.88  E-value: 2.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLV-LSLPFKMVLSQVQSP--FPSLCtlveCLYFVSM-----YGSVFTICFISMDRFLAIRYPLLVS 130
Cdd:cd15310  35 TNYLVVSLAVADLLVAtLVMPWVVYLEVTGGVwnFSRIC----CDVFVTLdvmmcTASILNLCAISIDRYTAVVMPVHYQ 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 131 HLR---SPRKIFGICCTIWVLVWTGSIP-IYSFHGKVEKYMCfhnmsddTWSAKVFFPL-EVFGFLLPMGIMGFCCSRSI 205
Cdd:cd15310 111 HGTgqsSCRRVSLMITAVWVLAFAVSCPlLFGFNTTGDPTVC-------SISNPDFVIYsSVVSFYLPFGVTLLVYVRIY 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 206 HILLGRRDHTQdwvqqkaciySIAASLAVFVVSFLPvhlgFFLQFLVRnsfiVECRAKQSISFFLQLSMCFSNVNCCLDV 285
Cdd:cd15310 184 VVLLREKKATQ----------MLAIVLGAFIVCWLP----FFLTHILN----THCQACHVPPELYSATTWLGYVNSALNP 245
                       250
                ....*....|.
gi 33695107 286 FCYYFVIKEFR 296
Cdd:cd15310 246 VIYTTFNIEFR 256
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
64-155 3.06e-04

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 41.49  E-value: 3.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  64 INLAVFDLLL-VLSLPFKMV-LSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFG 140
Cdd:cd15329  40 VSLAVSDLLVaLLVMPLAIIyELSGYWPFgEILCDVWISFDVLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMAL 119
                        90
                ....*....|....*
gi 33695107 141 ICCTIWVLVWTGSIP 155
Cdd:cd15329 120 MIAIVWLLSALISIP 134
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
61-155 3.08e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 41.68  E-value: 3.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS---LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15388  37 VFMLHLCIADLVVAFFQVLPQLVWDITDRFRGpdvLCRLVKYLQVVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARW 116
                        90
                ....*....|....*...
gi 33695107 138 IFGIcCTIWVLVWTGSIP 155
Cdd:cd15388 117 NGPV-CVAWAISLILSLP 133
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
58-208 3.44e-04

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 41.74  E-value: 3.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLL---LVLSLPFKMVLSQVQSPFPS-LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15306  34 ATNYFLMSLAVADLLvglFVMPIALLTILFEAMWPLPLvLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQASQYN 113
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIPIySFHGkVEKYMCFHNMSDDTWSAKVFFPLEVFG----FLLPMGIMGFCCSRSIHIL 208
Cdd:cd15306 114 SRATAFIKITVVWLISIGIAIPV-PIKG-IETDVDNPNNITCVLTKERFGDFILFGslaaFFTPLAIMIVTYFLTIHAL 190
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
59-159 3.73e-04

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 41.61  E-value: 3.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLL-VLSLPFKMVlSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15206  35 TNVFLLNLAVSDLLLaVFCMPFTLV-GQLLRNFifgEVMCKLIPYFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQT 113
                        90       100
                ....*....|....*....|....*
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPIYSF 159
Cdd:cd15206 114 LSHAYKVIAGIWLLSFLIMSPILVF 138
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
59-180 4.27e-04

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 41.32  E-value: 4.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSLPFKMVLSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15132  35 TNLYLSSMAVSDLLILLCLPFDLYRLWKSRPWifgEFLCRLYHYISEGCTYATILHITALSIERYLAICFPLRAKVLVTR 114
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 33695107 136 RKIFGICCTIWVLVWTGSIPIYSFHGkVEkYMCFHNMSDDTWSAK 180
Cdd:cd15132 115 RRVKCVIAALWAFALLSAGPFLFLVG-VE-QDNNIHPDDFSRECK 157
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
57-296 4.73e-04

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 41.06  E-value: 4.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  57 AATSIYMINLAVFDLLL-VLSLPFKMV--LSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15321  39 APQNLFLVSLAAADILVaTLIIPFSLAneLMGYWYFRKTWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKR 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIPIYSFHGKVE-----KYMCfhNMSDDTWsakvffplevfgFLLPMGIMGFCCSRSIHIL 208
Cdd:cd15321 119 TPRRIKCIILIVWLIAAVISLPPLIYKGKQKdeqggLPQC--KLNEEAW------------YILSSSIGSFFAPCLIMIL 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 209 LGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSfiveCRAKQSI-SFFLQLSMCfsnvNCCLDVFC 287
Cdd:cd15321 185 VYLRIYLIAKNREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPEL----CKVPHSLfQFFFWIGYC----NSSLNPVI 256

                ....*....
gi 33695107 288 YYFVIKEFR 296
Cdd:cd15321 257 YTIFNQDFR 265
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
93-149 6.37e-04

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 40.65  E-value: 6.37e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 33695107  93 LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCtIWVLV 149
Cdd:cd15137  79 LCTFAGFLATLSSEVSVLILTLITLDRFICIVFPFSGRRLGLRRAIIVLAC-IWLIG 134
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
58-240 6.51e-04

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 40.92  E-value: 6.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLLVLsLPFKMVLSQVQSPFPSL----CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15209  34 AGNIFVVSLSVADLVVAI-YPYPLILHAIFHNGWTLgqlhCQASGFIMGLSVIGSIFNITAIAINRYCYICHSLQYDRLY 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIPIYsFHGKVEK----YMCFHNMSDDT-WSAKVFfpleVFGFLLPMGIMGFCCSRSIHIL 208
Cdd:cd15209 113 SLRNTCCYLCLTWLLTVLAVLPNF-FIGSLQYdpriYSCTFAQTVSTvYTITVV----VIHFLLPLLIVSFCYLRIWVLV 187
                       170       180       190
                ....*....|....*....|....*....|..
gi 33695107 209 LGRRDHTQDWVQQKACIYSIAASLAVFVVSFL 240
Cdd:cd15209 188 LQVRQRVKPDQRPKLKPADVRNFLTMFVVFVL 219
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
91-296 7.56e-04

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 40.34  E-value: 7.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  91 PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK---IFGICCTIWVLVWTGSIPIYSF---HGKVE 164
Cdd:cd17790  70 TVACDLWLALDYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRaaiMIGLAWLISFVLWAPAILFWQYlvgERTVL 149
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 165 KYMCFHNMSDdtwSAKVFFPLEVFGFLLPMGIMgfccsrsihILLGRRDHtQDWVQQKACIYSIAASLAVFVVSFLPVHL 244
Cdd:cd17790 150 AGQCYIQFLS---QPIITFGTAIAAFYLPVTIM---------IILYWRIY-RETIKEKKAARTLSAILLAFILTWTPYNI 216
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 33695107 245 gfflqFLVRNSFIVECRAKQsisfFLQLSMCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd17790 217 -----MVLVSTFCKDCVPKT----LWELGYWLCYVNSTVNPMCYALCNKSFR 259
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
58-240 7.86e-04

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 40.66  E-value: 7.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLlVLSLPFKMVLSQVQSPFPSL----CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15401  34 AGNIFVVSLSVADLV-VAVYPYPLILLAIFHNGWTLgnihCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLRYDKLY 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRD 213
Cdd:cd15401 113 NMKKTCCYVCLTWVLTLAAIVPNFFVGSLQYDPRIYSCTFAQTVSSSYTITVVVVHFIVPLSIVTFCYLRIWVLVIQVKH 192
                       170       180
                ....*....|....*....|....*..
gi 33695107 214 HTQDWVQQKACIYSIAASLAVFVVSFL 240
Cdd:cd15401 193 RVRQDSKQKLKANDIRNFLTMFVVFVL 219
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
63-211 8.26e-04

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 40.50  E-value: 8.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  63 MINLAVFDLLL-VLSLPFKMVLSQVQSPFP--SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLlvSHLRSPRKIF 139
Cdd:cd15384  39 LLHLAIADLLVtFFCIPSEAIWAYTVAWLAgnTMCKLVKYLQVFGLYLSTYITVLISLDRCVAILYPM--KRNQAPERVR 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 140 GICCTIWVLVWTGSIP-IYSFHGKVEKYM-----CF-HNMSDDTWSAKVFFPLE-VFGFLLPMGIMgFCCSRSIHILLGR 211
Cdd:cd15384 117 RMVTVAWILSPIFSIPqAVIFHVERGPFVedfhqCVtYGFYTAEWQEQLYNMLSlVFMFPIPLVIM-VTCYVLIFITLSK 195
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
92-200 8.55e-04

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 40.30  E-value: 8.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  92 SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLvSHLRSPRKIFGICCTIWVLVWTGSIP---IYSFHGKVEK-YM 167
Cdd:cd15196  71 LLCRLVKYLQVVGMYASSYVLVATAIDRYIAICHPLS-SHRWTSRRVHLMVAIAWVLSLLLSIPqlfIFSYQEVGSGvYD 149
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 33695107 168 CFHNMSDDtWSAKV---FFPLEVfgFLLPMGIMGFC 200
Cdd:cd15196 150 CWATFEPP-WGLRAyitWFTVAV--FVVPLIILAFC 182
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
59-159 8.96e-04

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 40.23  E-value: 8.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLL-VLSLPFKMVLSQVQSPF--PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15055  35 TNLLLLSLAVADFLVgLLVMPFSMIRSIETCWYfgDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITI 114
                        90       100
                ....*....|....*....|....
gi 33695107 136 RKIfgicCTIWVLVWTGSIpIYSF 159
Cdd:cd15055 115 RRV----KICICLCWFVSA-LYSS 133
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
58-241 9.53e-04

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 40.02  E-value: 9.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFkMVLSQVQSPFPSLCTLVeCLYFVSM-----YGSVFTICFISMDRFLAIRYPLLVSH 131
Cdd:cd15053  34 ATNYFIVSLAVADLLVaILVMPF-AVYVEVNGGKWYLGPIL-CDIYIAMdvmcsTASIFNLCAISIDRYIAVTQPIKYAR 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 132 LRSPRKIFGICCTIWVLVWTGSIPI---YSFHGKVEKYMC-FHNMSDDTWSAkvffpleVFGFLLPMGIMGFCCSRSIHI 207
Cdd:cd15053 112 QKNSKRVLLTIAIVWVVSAAIACPLlfgLNNVPYRDPEECrFYNPDFIIYSS-------ISSFYIPCIVMLLLYYRIFRA 184
                       170       180       190
                ....*....|....*....|....*....|....
gi 33695107 208 LLGRRDHTQdwvqqkaciySIAASLAVFVVSFLP 241
Cdd:cd15053 185 LRREKKATK----------TLAIVLGVFLFCWLP 208
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
58-297 1.04e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 40.17  E-value: 1.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKMVLS--QVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAI----RYPLLVS 130
Cdd:cd15063  34 VTNLFIVSLACADLLVgTLVLPFSAVNEvlDVWIFGHTWCQIWLAVDVWMCTASILNLCAISLDRYLAItrpiRYPSLMS 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 131 HLRSPRKIFGicctIWVLVWT-GSIPIYSFHGKVEKYMCFHNMSDDTW-----SAKVFFPLEVFG-FLLPMGIMGFCCSR 203
Cdd:cd15063 114 TKRAKCLIAG----VWVLSFViCFPPLVGWNDGKDGIMDYSGSSSLPCtceltNGRGYVIYSALGsFYIPMLVMLFFYFR 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 204 sihILLGRRDHTQdwvqqkaciysIAASLAVFVVSFLPVHLGFFLQFLVRnSFIVECRAKQSISFFLQLSMCFSNVNCCL 283
Cdd:cd15063 190 ---IYRAARMETK-----------AAKTVAIIVGCFIFCWLPFFTVYLVR-AFCEDCIPPLLFSVFFWLGYCNSALNPCI 254
                       250
                ....*....|....
gi 33695107 284 dvfcYYFVIKEFRM 297
Cdd:cd15063 255 ----YALFSRDFRF 264
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
59-154 1.06e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 39.88  E-value: 1.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLS-LPFKMVLSQVQSPFPS--LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15326  35 TNYFIVNLAIADLLLSFTvLPFSATLEILGYWVFGriFCDIWAAVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTR 114
                        90
                ....*....|....*....
gi 33695107 136 RKIFGICCTIWVLVWTGSI 154
Cdd:cd15326 115 KRAILALLGVWVLSTVISI 133
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
61-296 1.19e-03

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 39.97  E-value: 1.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLV--ECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKI 138
Cdd:cd14972  35 ILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLlrKGSLVLSLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRV 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 139 FGICCTIWVL-VWTGSIPIysfhgkvekyMCFHNMSDDTWSAKVFFP--------LEVFGFLLPMGIMGFCcsrSIHILL 209
Cdd:cd14972 115 KVLIALVWVWsVLLALLPV----------LGWNCVLCDQESCSPLGPglpksylvLILVFFFIALVIIVFL---YVRIFW 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 210 GRRDHTQDWVQQKACIY----SIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDV 285
Cdd:cd14972 182 CLWRHANAIAARQEAAVpaqpSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDVLCPSVCDIQAVFYYFLVLALLNSAINP 261
                       250
                ....*....|.
gi 33695107 286 FCYYFVIKEFR 296
Cdd:cd14972 262 IIYAFRLKEMR 272
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
59-161 1.37e-03

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 39.82  E-value: 1.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLL-LVLSLPFKMVLSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15133  35 TNYYLFSLAVSDLLvLLLGMPLELYELWQNYPFllgSGGCYFKTFLFETVCLASILNVTALSVERYIAVVHPLAARTCST 114
                        90       100
                ....*....|....*....|....*..
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPIYSFHG 161
Cdd:cd15133 115 RPRVTRVLGCVWGVSMLCALPNTSLHG 141
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
59-148 1.38e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 39.74  E-value: 1.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDL---LLVLSLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15058  35 TNIFITSLACADLvmgLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRYQVLLTK 114
                        90
                ....*....|...
gi 33695107 136 RKIFGICCTIWVL 148
Cdd:cd15058 115 RRARVIVCVVWIV 127
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
66-182 1.41e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 39.92  E-value: 1.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  66 LAVFDLL-LVLSLPFKMV--LSQVQSPFP-SLCTLVE-CLYFVSMyGSVFTICFISMDRFLAIRYPLLVSHLRSPRK--- 137
Cdd:cd14981  44 LAITDLLgILLTSPVVLAvyASNFEWDGGqPLCDYFGfMMSFFGL-SSLLIVCAMAVERFLAITHPFFYNSHVKKRRarl 122
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 33695107 138 IFGICCTIWVLVwtGSIPIYSFHGKVEKY---MCFHNMSDDTWSAKVF 182
Cdd:cd14981 123 MLGAVWAFALLI--ASLPLLGLGSYVLQYpgtWCFLDFYSKNTGDAAY 168
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
62-200 1.50e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 39.44  E-value: 1.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  62 YMINLAVFDLL-LVLSLPFKMVLSqVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15215  37 FIFNLLVADLLqTVLVMPWVIATS-VPLFWPldsHLCTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRR 115
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHGKVEkYMCFHNMSDDTWSAKVFFPL--EVFGFLLPMGIMGFC 200
Cdd:cd15215 116 GYLLIYGTWIVSVLQSTPPLYGWGQAA-FDERNALCSVIWGSSYSYTIlsVVSSFVLPVIIMLAC 179
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
61-296 1.51e-03

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 39.84  E-value: 1.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLL-LVLSLPFKMV-LSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15976  37 ILIASLALGDLLhIIIDIPINVYkLLAEDWPFgVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKW 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIP--------IYSFHGKV-----------EKYMCFHNMSDDTWsakvffpLEVFGFLLPMGIMG 198
Cdd:cd15976 117 TAVEIVLIWVVSIILAVPeaigfdmiTMDYKGELlricllhpiqkTAFMQFYKTAKDWW-------LFSFYFCLPLACTA 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 199 FCCSRSIHILLGRRDHTQ----DWVQQKACIYSIAASLA-VFVVSFLPVHLGFFLQFLVRNSfiVECRAKQSISFFLQLS 273
Cdd:cd15976 190 VFYTLMTCEMLRKKNGMQialnDHLKQRREVAKTVFCLVlVFALCWLPLHLSRILKLTIYDE--KDPNRCELLSFFLVLD 267
                       250       260
                ....*....|....*....|....*.
gi 33695107 274 ---MCFSNVNCCLDVFCYYFVIKEFR 296
Cdd:cd15976 268 yigINMASLNSCINPIALYLVSKRFK 293
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
59-156 1.57e-03

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 39.55  E-value: 1.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLL-VLSLPFKMVlSQVQS--PFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15319  36 TNIFIVSLAVSDLFVaLLVMPWKAV-AEVAGywPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTQ 114
                        90       100
                ....*....|....*....|..
gi 33695107 136 RKIFGICCTIWVL-VWTGSIPI 156
Cdd:cd15319 115 RVALVMISVAWTLsVLISFIPV 136
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
60-291 1.85e-03

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 39.16  E-value: 1.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  60 SIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPS--LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd14973  35 SVYILNLAAADFLFLSCQAIQSLEDLLGGSLPGfaLCRLLATLMFFSYTVGLSLLAAISTERCLSVLFPIWYRCHRPKHL 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHnmsddtwSAKVFFPLEVFGFLLPMGIMGFCcsrsiHILLGRRDHTQD 217
Cdd:cd14973 115 SAVVCALLWALSLLLSVLESYFCGFLFWKFNES-------ACRTFNFLSALLFLLLFLVMCVS-----SLTLLIRVQCSS 182
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33695107 218 WVQQKACIYS-IAASLAVFVVSFLPVHLGFFLQFLVRNsfivecrakQSISFFLQLSMCFSNVNCCLDVFCYYFV 291
Cdd:cd14973 183 QRRPPTRLYVvILLTVLVFLLCGLPLGIYWFLLLWFSN---------YLFHTFHPISDLLSCVNSSANPIIYFFV 248
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
62-147 1.91e-03

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 39.39  E-value: 1.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  62 YMINLAVFDLL-LVLSLPFKMvLSQVQSPFPS-----LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRsP 135
Cdd:cd15135  41 HMVSLACSDLLvLLLGMPVEL-YSAIWDPFATpsgniACKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKALS-G 118
                        90
                ....*....|..
gi 33695107 136 RKIFGICCTIWV 147
Cdd:cd15135 119 SRVRLLICFVWL 130
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
94-203 2.01e-03

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 39.27  E-value: 2.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  94 CTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIfgICCTIWVLVWTGSIP-IYSFHG-KVEKYMCF-- 169
Cdd:cd15383  74 CRLLMFLKLFAMYSSAFVTVVISLDRHAAILNPLAIGSARRRNRI--MLCAAWGLSALLALPqLFLFHTvTATPPVNFtq 151
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 33695107 170 ---HNMSDDTWSAKVFFPLEVFG-FLLPMGIMGFCCSR 203
Cdd:cd15383 152 catHGSFPAHWQETLYNMFTFFClFLLPLLIMIFCYTR 189
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
56-128 2.02e-03

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 39.07  E-value: 2.02e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33695107  56 YAATSIYMINLAVFDLLLVLS-LPFKMVLSQVQSPF--PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLL 128
Cdd:cd15318  32 HTPTNFLLLSLALADMLLGLTvLPFSTIRSVESCWYfgDSFCRLHTCLDTLFCLTSIFHLCFISIDRHCAICDPLL 107
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
59-161 2.06e-03

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 39.37  E-value: 2.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLL-LVLSLPFKMVLSQVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15358  35 TNYYLFSLAVSDLLvLLLGMPLELYEMWSNYPFllgAGGCYFKTLLFETVCFASILNVTALSVERYIAVVHPLKAKYVVT 114
                        90       100
                ....*....|....*....|....*..
gi 33695107 135 PRKIFGICCTIWVLVWTGSIPIYSFHG 161
Cdd:cd15358 115 RTHAKRVIGAVWVVSILCSIPNTSLHG 141
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
61-299 2.14e-03

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 39.30  E-value: 2.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLLLVL-SLPFKMVLSQVQSPFPS--LCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLlvSHLRSPRK 137
Cdd:cd15195  37 ILIMHLALADLMVTFfNMPMDAVWNYTVEWLAGdlMCRVMMFLKQFGMYLSSFMLVVIALDRVFAILSPL--SANQARKR 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPiYSFHGKVEKYMC----FHNMSD-----DTWSAKVFFPLEVF-GFLLPMGIMGFC------- 200
Cdd:cd15195 115 VKIMLTVAWVLSALCSIP-QSFIFSVLRKMPeqpgFHQCVDfgsapTKKQERLYYFFTMIlSFVIPLIITVTCyllilfe 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 201 --------CSRSIHILLGRRDHTQDWVQQKACIYSIAASLAvFVVSFLPVH-LGFFLQFlvrnSFIVECRAKQSISFFLQ 271
Cdd:cd15195 194 iskmakraRDTPISNRRRSRTNSLERARMRTLRMTALIVLT-FIVCWGPYYvLGLWYWF----DKESIKNLPPALSHIMF 268
                       250       260
                ....*....|....*....|....*...
gi 33695107 272 LSMCFsnvNCCLDVFCYYFVIKEFRMNI 299
Cdd:cd15195 269 LLGYL---NPCLHPIIYGVFMKEIRNWI 293
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
59-148 2.82e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 38.87  E-value: 2.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLL-VLSLPFKMVLSQVQspfPSLCTLVECLYFVSM-----YGSVFTICFISMDRFLAIRYPLLVSHL 132
Cdd:cd15065  34 SNLFIVSLAVADLLVaLLVMTFAVVNDLLG---YWLFGETFCNIWISFdvmcsTASILNLCAISLDRYIHIKKPLKYERW 110
                        90
                ....*....|....*.
gi 33695107 133 RSPRKIFGICCTIWVL 148
Cdd:cd15065 111 MTTRRALVVIASVWIL 126
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
61-252 2.89e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 38.56  E-value: 2.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  61 IYMINLAVFDLL---LVLSLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK 137
Cdd:cd15050  37 LYIVSLSVADLIvgaVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTR 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 IFGICCTIWVLVWTGSIPIYSFH-------GKVEKYMCFHNMSDDTWsAKVFfpLEVFGFLLPMGIMGFCCSRsIHILLG 210
Cdd:cd15050 117 ASLMISGAWLLSFLWVIPILGWHhfarggeRVVLEDKCETDFHDVTW-FKVL--TAILNFYIPSLLMLWFYAK-IFKAVN 192
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 33695107 211 RrdhtqdwvQQKAciysiAASLAVFVVSFLPVHLGFFLQFLV 252
Cdd:cd15050 193 R--------ERKA-----AKQLGFIMAAFILCWIPYFILFMV 221
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
59-131 2.94e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 38.58  E-value: 2.94e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33695107  59 TSIYMINLAVFDLLLVLS-LPFKMVLSqVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSH 131
Cdd:cd15317  35 TNMLVLSLATADFLLGLCvMPFSMIRT-VETCWyfgDLFCKFHTGLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPS 110
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
62-296 3.07e-03

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 38.45  E-value: 3.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  62 YMINLAVFDLLL-VLSLP-FKMVLSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRK- 137
Cdd:cd15049  38 FLLSLACADLIIgLVSMNlYTVYLVMGYWPLgPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRa 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 138 --IFGICCTIWVLVWTGSIPIYSFHGK---VEKYMCFHNMSDDtwsAKVFFPLEVFGFLLPMGIMGFccsrsIHILLGRR 212
Cdd:cd15049 118 ilMIALAWVISFVLWAPAILGWQYFVGertVPDGQCYIQFLDD---PAITFGTAIAAFYLPVLVMTI-----LYWRIYRE 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 213 DhtqdwVQQKACIYSIAASLAVFVVSFLPVHLgfflqFLVRNSFIVECRAKQSISFFLQLsmCFsnVNCCLDVFCYYFVI 292
Cdd:cd15049 190 T-----ARERKAARTLSAILLAFIITWTPYNI-----LVLVSTFCAKCIPDTLWSFGYWL--CY--INSTINPFCYALCN 255

                ....
gi 33695107 293 KEFR 296
Cdd:cd15049 256 KTFR 259
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
104-251 3.93e-03

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 38.31  E-value: 3.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 104 SMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIfgICCTIWVLVWTGSIPIYSFH------GKVEKYMCFHNMSDDTW 177
Cdd:cd16002  83 AVFASIYSMTAIALDRYMAIIHPLQPRLSATATKV--VICVIWVLAFLLAFPQGYYSdteempGRVVCYVEWPEHEERKY 160
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107 178 SAKVFFPLEVFGFLLPMGIMGfCCSRSIHILLGRRDHTQD--------WVQQKACIYSIAASLAVFVVSFLPVHLGFFLQ 249
Cdd:cd16002 161 ETVYHVCVTVLIYFLPLLVIG-CAYTVVGITLWASEIPGDssdryheqVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQ 239

                ..
gi 33695107 250 FL 251
Cdd:cd16002 240 YF 241
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
58-148 5.19e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 37.72  E-value: 5.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLPFKMVLSQVQS--PF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15067  33 VTNYFIVSLAVADLLVgSIVMPFSILHEMTGGywLFgRDWCDVWHSFDVLASTASILNLCVISLDRYWAITDPISYPSRM 112
                        90
                ....*....|....*
gi 33695107 134 SPRKIFGICCTIWVL 148
Cdd:cd15067 113 TKRRALIMIALVWIC 127
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
62-155 5.63e-03

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 37.65  E-value: 5.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  62 YMI-NLAVFDLLL-VLSLPFKmVLSQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPR 136
Cdd:cd15330  37 YLIgSLAVTDLMVsVLVLPMA-ALYQVLNKWTlgqVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPR 115
                        90
                ....*....|....*....
gi 33695107 137 KIFGICCTIWVLVWTGSIP 155
Cdd:cd15330 116 RAAVLISLTWLIGFSISIP 134
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
59-154 5.73e-03

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 37.95  E-value: 5.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLS-LPFKMVLsQVQSPFP---SLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRS 134
Cdd:cd15325  35 THYFIVNLAVADLLLTSTvLPFSAIF-EILGYWAfgrVFCNIWAAVDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMT 113
                        90       100
                ....*....|....*....|
gi 33695107 135 PRKIFGICCTIWVLVWTGSI 154
Cdd:cd15325 114 ERRGLLALLCVWVLSLVISI 133
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
56-157 5.74e-03

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 37.92  E-value: 5.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  56 YAATSIYMINLAVFDLLL-VLSLPFKMVLSqVQSPF---PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPlLVSH 131
Cdd:cd15316  32 HSPTNFLIASLACADFLVgVTVMPFSTVRS-VESCWyfgESFCTFHTCCDVSFCYASLFHLCFISVDRYIAVTDP-LVYP 109
                        90       100
                ....*....|....*....|....*..
gi 33695107 132 LRSPRKIFGICCTI-WVLVWTGSIPIY 157
Cdd:cd15316 110 TKFTVSVSGICISVsWIFSLTYSFSVF 136
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
58-156 5.85e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 37.89  E-value: 5.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  58 ATSIYMINLAVFDLLL-VLSLP---FKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLR 133
Cdd:cd15308  34 TTNYFIVSLAVADLLLaLLVLPlyvYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCAISVDRFIAVSVPLNYNRRQ 113
                        90       100
                ....*....|....*....|...
gi 33695107 134 SPRKIFGICCTIWVLVWTGSIPI 156
Cdd:cd15308 114 GSVRQLLLISATWILSFAVASPV 136
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
59-148 8.36e-03

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 37.57  E-value: 8.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDL---LLVLSLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15958  35 TNLFITSLACADLvmgLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTASIETLCVIAIDRYLAITSPFRYQSLLTR 114
                        90
                ....*....|...
gi 33695107 136 RKIFGICCTIWVL 148
Cdd:cd15958 115 ARAKGIVCTVWAI 127
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
45-160 9.38e-03

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 37.29  E-value: 9.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  45 FSTFLKNRWPDYAATSIYMINLAVFDLLLV-LSLPFKMVLSQVQSPFPS--LCTLveCLYFVSM--YGSVFTICFISMDR 119
Cdd:cd15382  22 LLILLRNRRRKRSRVNILLMHLAIADLLVTfIMMPLEIGWAATVAWLAGdfLCRL--MLFFRAFglYLSSFVLVCISLDR 99
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 33695107 120 FLAIRYPLLVSHLRSPRKIFGICCtiWVLVWTGSIP-IYSFH 160
Cdd:cd15382 100 YFAILKPLRLSDARRRGRIMLAVA--WVISFLCSIPqSFIFH 139
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
59-148 9.61e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 37.19  E-value: 9.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695107  59 TSIYMINLAVFDLLLVLSL--PFKMVLSQVQSPF-PSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSP 135
Cdd:cd15959  35 TNVFVTSLACADLVMGLLVvpPGATILLTGHWPLgTTVCELWTSVDVLCVTASIETLCAIAVDRYLAITNPLRYEALVTK 114
                        90
                ....*....|...
gi 33695107 136 RKIFGICCTIWVL 148
Cdd:cd15959 115 RRARTAVCLVWAI 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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