extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 289547757  10 TALLCYSCKAQVSNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLNCVDDSQDYYVGKKNITCCDTDLCNASG 87
Cdd:cd23573    1 GSLQCYTCKAQLSNSNCQTETPCRENAKACKTDVIRAVGLLKVISKECSSSCTEDYQDYFVGKRNITCCSTDLCNVNG 78

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 289547757  10 TALLCYSCKAQVSNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLNCVDDSQDYYVGKKNITCCDTDLCNASG 87
Cdd:cd23573    1 GSLQCYTCKAQLSNSNCQTETPCRENAKACKTDVIRAVGLLKVISKECSSSCTEDYQDYFVGKRNITCCSTDLCNVNG 78

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547757    12 LLCYSCKaQVSNEDCLQVENCTQLGEQCWTARIRAV--GLLTVISKGCSL--NC----VDDSQDYYVgKKNITCCDTDLC 83
Cdd:smart00134   1 LQCYSCT-GNPDSSCSSEEECRSPDDVCLTVVAEVIsdSRGSVVYKGCATspICpgshGYEINLTIA-FLKVSCCQTDLC 78

                   ....*
gi 289547757    84 NASGA 88
Cdd:smart00134  79 NAAGP 83

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 289547757  10 TALLCYSCKAQVSNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLNCVDDSQDYYVGKKNITCCDTDLCNASG 87
Cdd:cd23573    1 GSLQCYTCKAQLSNSNCQTETPCRENAKACKTDVIRAVGLLKVISKECSSSCTEDYQDYFVGKRNITCCSTDLCNVNG 78

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 289547757   14 CYSCKAQvSNEDCLQVENCTQLGEQCWTARIRAVG---LLTVISKGCSL----NCVDDSQDYYVGKKNITCCDTDLCN 84
Cdd:pfam00021   1 CYSCLGV-SNEDCLSEVTCPLSDGQCVTTTLELPEgnlRGTVVSKGCARsscpRLLSDFINGGIISVSESCCQSDLCN 77

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547757  12 LLCYSCKAQVSNEDCL---QVENCTQLGEQCWTARIRAVGLLTVISKGCSLNCVDDSQDYYV-----GKKNITCCDTDLC 83
Cdd:cd00117    1 LKCYQCNSSNDPNCCNsspTLVTCSSPETFCRKIVGKVGGGETLVIRGCATECECGCTECCSgtgtsGTTCTSCCDTDLC 80

                 .
gi 289547757  84 N 84
Cdd:cd00117   81 N 81

extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like family; The SLURP-1-like family includes SLURP-1 and Ly6/PLAUR domain-containing protein 2 (LYPD2). SLURP-1 (also called ARS component B, or ARS (component B)-81/S, or anti-neoplastic urinary protein (ANUP)) has an antitumor activity. It was found to be a marker of late differentiation of the skin. It is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro SLURP-1 down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells SLURP-1 may be involved in regulation of intracellular Ca(2+) signaling. It may also have an immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation. LYPD2 is a lymphocyte antigen-6 family protein and shows high sequence similarity with SLURP-1. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 289547757  12 LLCYSCKAQVSNEDCLQVENCTQLGEQCWTARIRA------VGLLTVIsKGCSLNCVDDSQDYYVGKKNITCCDTDLCN 84
Cdd:cd23560    1 LRCYTCPEPTDSSLCTTIVNCSPNETACKTTLYSVdsgypfFGNITVT-RGCASECIPSDPDGIGETHPISCCNTDLCN 78

extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar proteins; Ly-6M is a novel member of the Ly-6 family of hematopoietic proteins. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547757   8 PGTALLCYSCKAqvsNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLNCVDDSQDYyvGKKNITCCDTDLCNASG 87
Cdd:cd23552    3 SAQALKCHECKG---IEDCYNPTSCNNQSRYCLTTWYTPPGEKTTVTKSCAYTCPDAPESL--ANSKASCCNTDLCNSAV 77

                 ..
gi 289547757  88 AH 89
Cdd:cd23552   78 SR 79

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547757  12 LLCYSCKaqvSNEDCLQVENCTQLGEQCWT---ARIRAVGLLTVISKGCSLN-CVDDSQDYYVGKKNI----TCCDTDLC 83
Cdd:cd23556    1 LRCYSCK---SNGDCRVEEVCALGQDLCRTtvmTLWEEGEELELVVKGCDVSgKTNASSSYRTGLNINslqeTVCSSDLC 77

                 .
gi 289547757  84 N 84
Cdd:cd23556   78 N 78