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Conserved domains on  [gi|5031631|ref|NP_005497|]
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lysosome membrane protein 2 isoform 1 [Homo sapiens]

Protein Classification

CD36 family protein( domain architecture ID 10471559)

CD36 family protein belongs to a class of scavenger receptors that may play roles in various signal transduction mechanisms; CD36 is a multifunctional membrane protein that acts as the cellular receptor for thrombospondin-1 (TSP-1) and is required for the anti-angiogenic activity of TSP-1, and generally promotes thrombosis in conditions of oxidative stress

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD36 pfam01130
CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is ...
 28-457 0e+00

CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.


:

Pssm-ID: 460076  Cd Length: 454  Bit Score: 557.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631     28 VFQKAVDQSIEKK-IVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEIL-RGETPRVEEVGPYTYRELRNKANIQFGDN 105
Cdd:pfam01130  16 VFPPIIFNQIIKKeLVLKPGSESYELWKKPPVPVYLKFYLFNVTNPEEFLgGGAKPKVEEVGPYVYREYREKVNVTFNDD 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631    106 GTTISAVSNKAYVFERDQSVGDPKiDLIRTLNIPVLTVIE-WSQVHFLREIIEAMLKAYQQKLFVTHTVDELLWGYKDEI 184
Cdd:pfam01130  96 NGTVSYQQRRTYIFDPELSVGSED-DTITTPNIPLLGAASkARNSSFLLRLLNLLLNSLGEKLFVTRTVGELLFGYEDPL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631    185 LSLIHVFRPDISPY---FGLFYEKNGTNDGDYVFLTGEDSYLNFTKIVEWNGKTSLDWWiTDKCNMINGTDGDSFHPLIT 261
Cdd:pfam01130 175 LDLAKKLLPSLPIPfdkFGLFYGRNGTDDGVFTVYTGKDDISKLGRIDSWNGKTHLDWW-EGECNMINGTDGTLFPPFLT 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631    262 KDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTS---DNAGFCIPEGN-CLGSGVLNVSICKNGAPIIM 337
Cdd:pfam01130 254 KDDTLYIFSPDLCRSLPLVYEKDVTVKGIPGYRYVLPPNVFDNGTvnpDNKCFCPNKGNeCLPSGLLDVSPCKYGAPIFL 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631    338 SFPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHI 417
Cdd:pfam01130 334 SLPHFYLADPSYLEAVEGLNPNKEKHETYLDIEPTTGIPLEAAKRLQINLLVEPVPGISLLKNLPNVILPLFWFEESAEL 413

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 5031631    418 DKETASRLKSMINTT-LIITNIPYIIMALGVFFGLVFTWLA 457
Cdd:pfam01130 414 DDELANLLKKLLLVLpNIGLYLQYGLLALGLILLLVALILL 454
 
Name Accession Description Interval E-value
CD36 pfam01130
CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is ...
 28-457 0e+00

CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.


Pssm-ID: 460076  Cd Length: 454  Bit Score: 557.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631     28 VFQKAVDQSIEKK-IVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEIL-RGETPRVEEVGPYTYRELRNKANIQFGDN 105
Cdd:pfam01130  16 VFPPIIFNQIIKKeLVLKPGSESYELWKKPPVPVYLKFYLFNVTNPEEFLgGGAKPKVEEVGPYVYREYREKVNVTFNDD 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631    106 GTTISAVSNKAYVFERDQSVGDPKiDLIRTLNIPVLTVIE-WSQVHFLREIIEAMLKAYQQKLFVTHTVDELLWGYKDEI 184
Cdd:pfam01130  96 NGTVSYQQRRTYIFDPELSVGSED-DTITTPNIPLLGAASkARNSSFLLRLLNLLLNSLGEKLFVTRTVGELLFGYEDPL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631    185 LSLIHVFRPDISPY---FGLFYEKNGTNDGDYVFLTGEDSYLNFTKIVEWNGKTSLDWWiTDKCNMINGTDGDSFHPLIT 261
Cdd:pfam01130 175 LDLAKKLLPSLPIPfdkFGLFYGRNGTDDGVFTVYTGKDDISKLGRIDSWNGKTHLDWW-EGECNMINGTDGTLFPPFLT 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631    262 KDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTS---DNAGFCIPEGN-CLGSGVLNVSICKNGAPIIM 337
Cdd:pfam01130 254 KDDTLYIFSPDLCRSLPLVYEKDVTVKGIPGYRYVLPPNVFDNGTvnpDNKCFCPNKGNeCLPSGLLDVSPCKYGAPIFL 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631    338 SFPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHI 417
Cdd:pfam01130 334 SLPHFYLADPSYLEAVEGLNPNKEKHETYLDIEPTTGIPLEAAKRLQINLLVEPVPGISLLKNLPNVILPLFWFEESAEL 413

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 5031631    418 DKETASRLKSMINTT-LIITNIPYIIMALGVFFGLVFTWLA 457
Cdd:pfam01130 414 DDELANLLKKLLLVLpNIGLYLQYGLLALGLILLLVALILL 454
 
Name Accession Description Interval E-value
CD36 pfam01130
CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is ...
 28-457 0e+00

CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.


Pssm-ID: 460076  Cd Length: 454  Bit Score: 557.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631     28 VFQKAVDQSIEKK-IVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEIL-RGETPRVEEVGPYTYRELRNKANIQFGDN 105
Cdd:pfam01130  16 VFPPIIFNQIIKKeLVLKPGSESYELWKKPPVPVYLKFYLFNVTNPEEFLgGGAKPKVEEVGPYVYREYREKVNVTFNDD 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631    106 GTTISAVSNKAYVFERDQSVGDPKiDLIRTLNIPVLTVIE-WSQVHFLREIIEAMLKAYQQKLFVTHTVDELLWGYKDEI 184
Cdd:pfam01130  96 NGTVSYQQRRTYIFDPELSVGSED-DTITTPNIPLLGAASkARNSSFLLRLLNLLLNSLGEKLFVTRTVGELLFGYEDPL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631    185 LSLIHVFRPDISPY---FGLFYEKNGTNDGDYVFLTGEDSYLNFTKIVEWNGKTSLDWWiTDKCNMINGTDGDSFHPLIT 261
Cdd:pfam01130 175 LDLAKKLLPSLPIPfdkFGLFYGRNGTDDGVFTVYTGKDDISKLGRIDSWNGKTHLDWW-EGECNMINGTDGTLFPPFLT 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631    262 KDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTS---DNAGFCIPEGN-CLGSGVLNVSICKNGAPIIM 337
Cdd:pfam01130 254 KDDTLYIFSPDLCRSLPLVYEKDVTVKGIPGYRYVLPPNVFDNGTvnpDNKCFCPNKGNeCLPSGLLDVSPCKYGAPIFL 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031631    338 SFPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHI 417
Cdd:pfam01130 334 SLPHFYLADPSYLEAVEGLNPNKEKHETYLDIEPTTGIPLEAAKRLQINLLVEPVPGISLLKNLPNVILPLFWFEESAEL 413

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 5031631    418 DKETASRLKSMINTT-LIITNIPYIIMALGVFFGLVFTWLA 457
Cdd:pfam01130 414 DDELANLLKKLLLVLpNIGLYLQYGLLALGLILLLVALILL 454
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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