|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
202-617 |
1.80e-160 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 477.10 E-value: 1.80e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 202 DAVDVRQELDLRIGAAFTRFQTLRLQRifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKvthdhkdgiv 281
Cdd:cd00186 5 NAQLARRILDRLVGFNLSRLLTKKLRR-------KGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK---------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 282 efnwkrhrlfnhtaclvlyqlcvedpMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYIS 361
Cdd:cd00186 68 --------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLIT 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 362 YPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERggPTPRNGNKSDQAHPPIHPTKYT------NNLQGDEQRLYE 435
Cdd:cd00186 122 YPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLGR--RNPKRGKKEQGAHEAIRPTKVAptpeleANLSEDEFKLYE 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 436 FIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDK-ILPVYEQGSHFQPSTVEMVDGETSP 514
Cdd:cd00186 200 LIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEeEPPPLKEGDELKLEEVELEEKETQP 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 515 PKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKL 594
Cdd:cd00186 280 PPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEK-KKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDE 358
|
410 420
....*....|....*....|...
gi 10835218 595 ICDGKKDKFVVLRQQVQKYKQVF 617
Cdd:cd00186 359 IAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
36-711 |
4.30e-157 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 484.50 E-value: 4.30e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 36 VLCVAEKNDAAKGIADLLSNGRM--RRREGLSkfnkIYEFDyhlyGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVL 113
Cdd:PRK07219 2 ELIIAEKNNAARRIADILSGGKAkkKRVNGVP----YYEFE----RKGEKWIVIGLSGHIVTVDFPEEYGDWRDVDPAEL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 114 FEAEIEKYCP-ENFVDIKKTLERETRQcqaLVIWTDCDREGENIGFEIIHVCKAVKpNLQVLRARFSEITPHAVRTACEN 192
Cdd:PRK07219 74 IDADPVKKITkQNYINALKKLAKDADE---IIIATDYDREGELIGKEAYHILREVC-QVPVKRARFSSLTKKEIRKAFEN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 193 LTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevLAEQ-LISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIK 271
Cdd:PRK07219 150 PDEIDFNLADAGEARQIIDLYWGAALTRFLSLSVRQ-----LGRWdFLSVGRVQTPTLAFIVDREREIRAFDPEDYWKIE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 272 VTHD----HKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKET 347
Cdd:PRK07219 225 ALLDkeaqYFYRDLIGGHEAEKFWDEEEAEEIYEKLKGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRA 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY--TNN 425
Cdd:PRK07219 305 MEIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKLSKKKEYGPYAESILEQENIKPTEGKKETTDHPPIHPVDVpkREE 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 426 LQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTV 505
Cdd:PRK07219 385 LSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKFDEKELPDLEEGEKLKVNKI 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 506 EMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVglTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLR 585
Cdd:PRK07219 465 EIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYV--IEGDPPRPTDLGIAVIEALEKYAPEIVSEEMT 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 586 AELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLdealaqyfgnGTELAQQEDIYPAMPEPIRKCPQCNKDM 665
Cdd:PRK07219 543 AQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKEI----------GDHLAGSLKAENRSLKTIGKCPECGGDL 612
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|
gi 10835218 666 VLKTKKNGGFYLSCMGFPECRSAVWLPD----SVLeasrdSSVCPVCQPH 711
Cdd:PRK07219 613 IIIRTDKGSRFVGCSGYPDCRNTFPLPStgriKVL-----DEVCEKCGLP 657
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
195-602 |
5.46e-135 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 412.41 E-value: 5.46e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 195 EPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVT- 273
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLKG-------NKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATl 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 274 HDHKDGIVEFNWKRHRLFNHTACLVLYQLCvEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEK 353
Cdd:pfam01131 74 KDGGGVFANAKWKRGRIFDKEEAEAILEKL-KKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 354 LYTQ-GYISYPRTETNIFPRDLNLTVLVEQQTPDP-RWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY---TNNLQG 428
Cdd:pfam01131 153 LYEKhGLITYPRTDSTYLSDDATLKAILEYLTKNYgKYLPYAPRLLKKTKGKLTVGNAKVTAHEAIRPTGDipvLPELSD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 429 DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSD-KILPVYEQGSHFQPSTVEM 507
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDeEELPELKEGEELKVTQVEV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 508 VDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMgYEMSKPDLRAE 587
Cdd:pfam01131 313 EEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERKK-KSLVPTELGKALVEALEKF-PDLVDPELTAE 390
|
410
....*....|....*
gi 10835218 588 LEADLKLICDGKKDK 602
Cdd:pfam01131 391 LEEKLDEIAEGKLDW 405
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
315-568 |
7.36e-107 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 332.67 E-value: 7.36e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 315 RSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR-WGAFA 393
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKeYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 394 QSILERGGptPRNGNKSDQAHPPIHPTKYTN------NLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVA 467
Cdd:smart00437 81 VVLLKPRK--PRKGKKAQGAHEAIRPTKPIFtpelekELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 468 HGLMILARNYLDVYPYDHW-SDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 546
Cdd:smart00437 159 KGKTLLFDGWLKVYPEEKKeEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLL 238
|
250 260
....*....|....*....|..
gi 10835218 547 ARMYVGLTPdKRFLPGHLGMGL 568
Cdd:smart00437 239 DRGYVTKKK-KKLIPTELGIAV 259
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
131-608 |
1.54e-91 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 302.01 E-value: 1.54e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 131 KTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPnlqVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQEL 210
Cdd:COG0550 63 KELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKP---VKRVVFNEITKKAIKEAFKNPRDIDMNLVDAQQARRIL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 211 DLRIGAAFTRFQTLRLQRifpevlaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKR--- 287
Cdd:COG0550 140 DRLVGYNLSPLLWKKVKR---------GLSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVKidg 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 288 HRLFNHTACLVLYQLCvEDPMATVVEVRSKPKSKwRPQAL-DTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTE 366
Cdd:COG0550 211 KKILDEEEAEAILAAL-KGKTFTVTSVEKKPKKR-NPPPPfTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTD 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 367 -TNIfPRDLNltvlveqqtpdprwGAFAQSILERGGP-----TPR--NGNKSDQ-AHPPIHPT---KYTNNLQGDEQRLY 434
Cdd:COG0550 289 sVRL-SEDAV--------------AAAREYIEALYGKeylpeKPRvyKTSKNAQeAHEAIRPTgvtRTPESLSGDEFKLY 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 435 EFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDH-----WSDKILPVYEQGSHFQPSTVEMVD 509
Cdd:COG0550 354 DLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeeeEEEKRLPPLKEGEKLKLKKIEPEQ 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 510 GETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGM---GLVEGYDSmgyEMSKPDLRA 586
Cdd:COG0550 434 HFTKPPPRYTEASLVKAMEELGIGRPSTYASIIETLQDRGYVERE-GKRLVPTELGFiviDLLEEHFP---DLVDYEFTA 509
|
490 500
....*....|....*....|..
gi 10835218 587 ELEADLKLICDGKKDKFVVLRQ 608
Cdd:COG0550 510 KMEEKLDEIAEGKLDWKDVLEE 531
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
39-685 |
2.78e-85 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 287.49 E-value: 2.78e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 39 VAEKNDAAKGIADLLSNGRMRRReglSKFNKIYefdYHLYGQNVTMVMTSVSGHLLA---------HDFQMQFRkwqscn 109
Cdd:TIGR01057 1 IAEKPKVAAKIAGALSDGRVLKK---SEYGVPY---WEVRRDGKKIIVASAVGHLFGlhpksrggyPVFDIEWV------ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 110 PLVLFEAEIEkYCPENFVDIKKTLERETRqcqaLVIWTDCDREGENIGFEIIHVCKAVKPnlqVLRARFSEITPHAVRTA 189
Cdd:TIGR01057 69 PIFEFDKGKG-YVSKYIKALSKLAKGADE----YINACDYDIEGEVIGFKALKYFCGVER---AKRMKFSTLTKQDIRRA 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 190 CENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHR 269
Cdd:TIGR01057 141 YANPEEIDYGMVDAGMARHILDWYWGINLSRALMEAIRAAAGRWV---ILSAGRVQGPTLAFLVEREREINLFVPKPYWV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 270 IKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMR 349
Cdd:TIGR01057 218 IKATLEKGGGVFDARPEKWKIWSEEEAKSIKEELKKSPWAAVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQS 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 350 IAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPT--KYTNNLQ 427
Cdd:TIGR01057 298 IAQELYEEALISYPRTSSQKLPPSINYRAILDNLAKGPLYREAAERLLETGVLKPVEGKKEDPAHPAIHPTgeIPSQELS 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 428 GDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEM 507
Cdd:TIGR01057 378 KDEKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYHYSKFEEKELPPLDRGDKIKVVRVDV 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 508 VDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPghLGMGLVEGYDSMGYEMSKPDLRAE 587
Cdd:TIGR01057 458 RVKETQPPARYDKASLIREMESRGLGTKATRARIIETLYKRGYIEGKKSIKVTP--LGEAVIETLQRYCPEIISEELTRR 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 588 LEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAvakAKKLDEAlaqyfgnGTELA---QQEDIypampepIRKCPQCNKD 664
Cdd:TIGR01057 536 FESKLEDIMSGRITKDEVIDEAKKRLRKILEEF---KKRLDDI-------GIELGkslGSVEV-------VGKCPKCGGK 598
|
650 660
....*....|....*....|.
gi 10835218 665 MVLKTKKNGGFYLsCMGFPEC 685
Cdd:TIGR01057 599 LVSKYAKKGRFVG-CSNYPEC 618
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
35-193 |
4.74e-48 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 167.80 E-value: 4.74e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 35 KVLCVAEKNDAAKGIADLLSNGRMRRREGlskfnkiyeFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPL--V 112
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILGGGSKKKGKG---------RYYEFYGEGGGYVVTWASGHLLELDFPEEYDPWDKVWPLedP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 113 LFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKpNLQVLRARFSEITPHAVRTACEN 192
Cdd:cd03362 72 LFPAPFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVK-RKPVKRAWFSSLTPKAIRRAFKN 150
|
.
gi 10835218 193 L 193
Cdd:cd03362 151 L 151
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
895-939 |
9.60e-19 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 80.53 E-value: 9.60e-19
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 10835218 895 TSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDEN 939
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGREKQCGFFQWADEV 45
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
811-852 |
5.64e-17 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 75.52 E-value: 5.64e-17
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 10835218 811 VTCNCGQEAVLLTVRKEGPNRGRQFFKCNGG---SCNFFLWADSP 852
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGrekQCGFFQWADEV 45
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
655-694 |
4.51e-12 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 61.12 E-value: 4.51e-12
10 20 30 40
....*....|....*....|....*....|....*....|
gi 10835218 655 IRKCPQCNKDMVLKTKKNGGFYlSCMGFPECRSAVWLPDS 694
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFV-GCSNYPECRFTRPLKKN 39
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
36-181 |
1.53e-09 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 55.83 E-value: 1.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 36 VLCVAEKNDAAKGIADLLSNGrmrrreglskfnkiyefdyhlygqnvTMVMTSVSGHLLAHDFqmqfrkwqscnplvlfe 115
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGGG--------------------------FQAVVAVLGHLLSLEK----------------- 37
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10835218 116 aeiekycpENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPnlQVLRARFSEI 181
Cdd:pfam01751 38 --------GPKKKALKALKELALKAKEVILATDPDREGEAIALKLLELKELLEN--AGGRVEFSEL 93
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
128-168 |
9.91e-07 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 47.26 E-value: 9.91e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 10835218 128 DIKKTLERETRQCQaLVIWTDCDREGENIGFEIIHVCKAVK 168
Cdd:smart00493 36 EQIKLLKKLAKKAE-VILATDPDREGEAIAWELAELLKPAG 75
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
202-617 |
1.80e-160 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 477.10 E-value: 1.80e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 202 DAVDVRQELDLRIGAAFTRFQTLRLQRifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKvthdhkdgiv 281
Cdd:cd00186 5 NAQLARRILDRLVGFNLSRLLTKKLRR-------KGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK---------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 282 efnwkrhrlfnhtaclvlyqlcvedpMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYIS 361
Cdd:cd00186 68 --------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLIT 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 362 YPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERggPTPRNGNKSDQAHPPIHPTKYT------NNLQGDEQRLYE 435
Cdd:cd00186 122 YPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLGR--RNPKRGKKEQGAHEAIRPTKVAptpeleANLSEDEFKLYE 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 436 FIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDK-ILPVYEQGSHFQPSTVEMVDGETSP 514
Cdd:cd00186 200 LIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEeEPPPLKEGDELKLEEVELEEKETQP 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 515 PKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKL 594
Cdd:cd00186 280 PPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEK-KKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDE 358
|
410 420
....*....|....*....|...
gi 10835218 595 ICDGKKDKFVVLRQQVQKYKQVF 617
Cdd:cd00186 359 IAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
36-711 |
4.30e-157 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 484.50 E-value: 4.30e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 36 VLCVAEKNDAAKGIADLLSNGRM--RRREGLSkfnkIYEFDyhlyGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVL 113
Cdd:PRK07219 2 ELIIAEKNNAARRIADILSGGKAkkKRVNGVP----YYEFE----RKGEKWIVIGLSGHIVTVDFPEEYGDWRDVDPAEL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 114 FEAEIEKYCP-ENFVDIKKTLERETRQcqaLVIWTDCDREGENIGFEIIHVCKAVKpNLQVLRARFSEITPHAVRTACEN 192
Cdd:PRK07219 74 IDADPVKKITkQNYINALKKLAKDADE---IIIATDYDREGELIGKEAYHILREVC-QVPVKRARFSSLTKKEIRKAFEN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 193 LTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevLAEQ-LISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIK 271
Cdd:PRK07219 150 PDEIDFNLADAGEARQIIDLYWGAALTRFLSLSVRQ-----LGRWdFLSVGRVQTPTLAFIVDREREIRAFDPEDYWKIE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 272 VTHD----HKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKET 347
Cdd:PRK07219 225 ALLDkeaqYFYRDLIGGHEAEKFWDEEEAEEIYEKLKGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRA 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY--TNN 425
Cdd:PRK07219 305 MEIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKLSKKKEYGPYAESILEQENIKPTEGKKETTDHPPIHPVDVpkREE 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 426 LQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTV 505
Cdd:PRK07219 385 LSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKFDEKELPDLEEGEKLKVNKI 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 506 EMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVglTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLR 585
Cdd:PRK07219 465 EIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYV--IEGDPPRPTDLGIAVIEALEKYAPEIVSEEMT 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 586 AELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLdealaqyfgnGTELAQQEDIYPAMPEPIRKCPQCNKDM 665
Cdd:PRK07219 543 AQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKEI----------GDHLAGSLKAENRSLKTIGKCPECGGDL 612
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|
gi 10835218 666 VLKTKKNGGFYLSCMGFPECRSAVWLPD----SVLeasrdSSVCPVCQPH 711
Cdd:PRK07219 613 IIIRTDKGSRFVGCSGYPDCRNTFPLPStgriKVL-----DEVCEKCGLP 657
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
195-602 |
5.46e-135 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 412.41 E-value: 5.46e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 195 EPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVT- 273
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLKG-------NKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATl 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 274 HDHKDGIVEFNWKRHRLFNHTACLVLYQLCvEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEK 353
Cdd:pfam01131 74 KDGGGVFANAKWKRGRIFDKEEAEAILEKL-KKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 354 LYTQ-GYISYPRTETNIFPRDLNLTVLVEQQTPDP-RWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY---TNNLQG 428
Cdd:pfam01131 153 LYEKhGLITYPRTDSTYLSDDATLKAILEYLTKNYgKYLPYAPRLLKKTKGKLTVGNAKVTAHEAIRPTGDipvLPELSD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 429 DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSD-KILPVYEQGSHFQPSTVEM 507
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDeEELPELKEGEELKVTQVEV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 508 VDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMgYEMSKPDLRAE 587
Cdd:pfam01131 313 EEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERKK-KSLVPTELGKALVEALEKF-PDLVDPELTAE 390
|
410
....*....|....*
gi 10835218 588 LEADLKLICDGKKDK 602
Cdd:pfam01131 391 LEEKLDEIAEGKLDW 405
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
37-726 |
1.22e-118 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 380.64 E-value: 1.22e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 37 LCVAEKNDAAKGIADLLSNGRMRRReglskfnKIYEFDYHLYGQNV--TMVMtSVSGHLLAHDFQMQFRKWQSCNPLVLF 114
Cdd:PRK07220 3 LIITEKNIAARRIAQILAPKKPKKT-------RVSGVDVYRYEDNGddTVVV-GLSGHIVNIDFPKEYNNWQKVDARDLI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 115 EAEIEK-YCPENFVDIKKTLERE-TRqcqaLVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACEN 192
Cdd:PRK07220 75 DAEIITtPTQKKIVTALKKLGKEaDR----VTIATDYDREGELIGVEALNIIKKVNPDIKFDRVRYSAITKKEIERAFSN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 193 LTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKV 272
Cdd:PRK07220 151 PVEVDFNLADAGHSRQVIDLVWGAALTRYISLAAGR-----LGKMFLSVGRVQSPTLALIVDREKEREAFVPTPYWEIYA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 273 THDHKDGIVEFNWKRHRLFNHT-ACLVLYQLCVEdpmATVVEVRSKPKSKWRPQALDTVELEKLASrKLRINAKETMRIA 351
Cdd:PRK07220 226 TLENNGETFVAQHSTRRFWEKEeADRVFEKLGKT---AEVTEVEKGTKTDKPPTPFNTTEFISAAN-SIGFSAANAMRIA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 352 EKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPrWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYT--NNLQGD 429
Cdd:PRK07220 302 ESLYTNGYISYPRTDNTVYPESLDLREQIEIFAEGP-FGEYAQKLLEKGELVPTRGKKETTDHPPIYPASLAkkSELKED 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 430 EQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVD 509
Cdd:PRK07220 381 EWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPYNAPEDRLLPELSEGEELKVKKKEMLD 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 510 GETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdkrFLPGHLGMGLVEGYDSMGYEMSKPDLRAELE 589
Cdd:PRK07220 461 KETQPPGRYGQGRLIKLMEDLGLGTKATRHEIISKLYSRAYIHGNP---IQPTNTAFAVVDALEKYAPTITKPDMTSRLE 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 590 ADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAqyfgNGTelaqQEDiypampEPIRKCPQCNKDMVLKT 669
Cdd:PRK07220 538 EDMDKIAEGKIKEDAVLEESREMLEQVFDELDKNREKIRESLR----EGL----RED------KIIGKCPLCGSDLMVRR 603
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10835218 670 KKNGGFYLSCMGFPECRSAVWLPDS----VLEAsrdssvcpVCQPHPVYRLKLKfKRGSLP 726
Cdd:PRK07220 604 SKRGSRFIGCEGYPECTFSLPLPKSgqiiVTDK--------VCEAHGLNHIRII-NGGKRP 655
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
315-568 |
7.36e-107 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 332.67 E-value: 7.36e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 315 RSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR-WGAFA 393
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKeYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 394 QSILERGGptPRNGNKSDQAHPPIHPTKYTN------NLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVA 467
Cdd:smart00437 81 VVLLKPRK--PRKGKKAQGAHEAIRPTKPIFtpelekELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 468 HGLMILARNYLDVYPYDHW-SDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 546
Cdd:smart00437 159 KGKTLLFDGWLKVYPEEKKeEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLL 238
|
250 260
....*....|....*....|..
gi 10835218 547 ARMYVGLTPdKRFLPGHLGMGL 568
Cdd:smart00437 239 DRGYVTKKK-KKLIPTELGIAV 259
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
37-726 |
1.73e-94 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 320.64 E-value: 1.73e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 37 LCVAEKNDAAKGIADLLSNG---RMRRREGLSkfnkIYEFDyhlygqnvTMVMTSVSGHLLAHDFQMQFRKWQSCN--PL 111
Cdd:PRK14973 3 LIIAEKNIAANRIAQILAGKtkvQVKKDGGVS----TYSFD--------DTVVVGLRGHVVEVDFEPGYTNWRSEEhtPR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 112 VLFEAEIEKYCPENfvDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACE 191
Cdd:PRK14973 71 SLIDADTIKKPTEK--KIVGLIQKLAKKADRVTIATDFDTEGELIGKEAYELVRAVNPKVPIDRARFSAITKEEIVTAFA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 192 NLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIK 271
Cdd:PRK14973 149 EPTDLDFALAAAGEARQIIDLIWGASLTRFISLAAHR-----GGDNILSVGRVQSPTLAMIVDREKEIEAFVPEKYWMLS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 272 VTHDhKDGI-VEfnwKRH---RLFNHTACLVLYQLCVEDPMATvvEVRSKPKSKWRPQALDTVELEKLASRkLRINAKET 347
Cdd:PRK14973 224 LATE-KDGEgIE---ARHthgRFTDSAAAEAAYDATKEPLVVT--EVKEGHKVDRAPTPFDTTTFIVAASR-LGFSAANA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVE--QQTPDPRWGAFAQSILErggPTPRNGNKSDQAHPPIHPTKYTNN 425
Cdd:PRK14973 297 MRIAEDLYMNGYISYPRTDNTIYPKSLDLNGVLAtlAKGAFSKDVAWVKDNRR---PVPTRGKKSSTDHPPIHPTGVATR 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 426 LQ-GDEQ-RLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPS 503
Cdd:PRK14973 374 EElGDDRwKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPYSEAKENILPAFALGEKLPIL 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 504 TVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKrflPGHLGMGLVEGYDSMGYEMSKPD 583
Cdd:PRK14973 454 AVNLEEKETQPPARYSQSRLIQRMEELGLGTKSTRHEVIGKLVSRKYIEGNPLR---PTLVGRAVTESLEEHAGTITEPD 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 584 LRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFieavakaKKLDEALAQYfgnGTELAQQEdiypAMPEPIRKCPQCNK 663
Cdd:PRK14973 531 MTQTLEEHMQQIKERKRTRDDVVTESRKMLHRAF-------DELEANEAVI---GRDIMERT----AEELTIGPCPVCGK 596
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10835218 664 DMVLKtKKNGGFYLSCMGFPECRSAVWLPDSVL-EASRDSSVCPVcqpHPVYRLKLkFKRGSLP 726
Cdd:PRK14973 597 DLRIK-HIGSSQFIGCSGYPDCTFNIGLPGTTWgWAIRTDEVCPI---HHLNHVRL-IRKGARP 655
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
131-608 |
1.54e-91 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 302.01 E-value: 1.54e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 131 KTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPnlqVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQEL 210
Cdd:COG0550 63 KELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKP---VKRVVFNEITKKAIKEAFKNPRDIDMNLVDAQQARRIL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 211 DLRIGAAFTRFQTLRLQRifpevlaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKR--- 287
Cdd:COG0550 140 DRLVGYNLSPLLWKKVKR---------GLSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVKidg 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 288 HRLFNHTACLVLYQLCvEDPMATVVEVRSKPKSKwRPQAL-DTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTE 366
Cdd:COG0550 211 KKILDEEEAEAILAAL-KGKTFTVTSVEKKPKKR-NPPPPfTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTD 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 367 -TNIfPRDLNltvlveqqtpdprwGAFAQSILERGGP-----TPR--NGNKSDQ-AHPPIHPT---KYTNNLQGDEQRLY 434
Cdd:COG0550 289 sVRL-SEDAV--------------AAAREYIEALYGKeylpeKPRvyKTSKNAQeAHEAIRPTgvtRTPESLSGDEFKLY 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 435 EFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDH-----WSDKILPVYEQGSHFQPSTVEMVD 509
Cdd:COG0550 354 DLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeeeEEEKRLPPLKEGEKLKLKKIEPEQ 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 510 GETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGM---GLVEGYDSmgyEMSKPDLRA 586
Cdd:COG0550 434 HFTKPPPRYTEASLVKAMEELGIGRPSTYASIIETLQDRGYVERE-GKRLVPTELGFiviDLLEEHFP---DLVDYEFTA 509
|
490 500
....*....|....*....|..
gi 10835218 587 ELEADLKLICDGKKDKFVVLRQ 608
Cdd:COG0550 510 KMEEKLDEIAEGKLDWKDVLEE 531
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
39-685 |
2.78e-85 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 287.49 E-value: 2.78e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 39 VAEKNDAAKGIADLLSNGRMRRReglSKFNKIYefdYHLYGQNVTMVMTSVSGHLLA---------HDFQMQFRkwqscn 109
Cdd:TIGR01057 1 IAEKPKVAAKIAGALSDGRVLKK---SEYGVPY---WEVRRDGKKIIVASAVGHLFGlhpksrggyPVFDIEWV------ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 110 PLVLFEAEIEkYCPENFVDIKKTLERETRqcqaLVIWTDCDREGENIGFEIIHVCKAVKPnlqVLRARFSEITPHAVRTA 189
Cdd:TIGR01057 69 PIFEFDKGKG-YVSKYIKALSKLAKGADE----YINACDYDIEGEVIGFKALKYFCGVER---AKRMKFSTLTKQDIRRA 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 190 CENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHR 269
Cdd:TIGR01057 141 YANPEEIDYGMVDAGMARHILDWYWGINLSRALMEAIRAAAGRWV---ILSAGRVQGPTLAFLVEREREINLFVPKPYWV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 270 IKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMR 349
Cdd:TIGR01057 218 IKATLEKGGGVFDARPEKWKIWSEEEAKSIKEELKKSPWAAVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQS 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 350 IAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPT--KYTNNLQ 427
Cdd:TIGR01057 298 IAQELYEEALISYPRTSSQKLPPSINYRAILDNLAKGPLYREAAERLLETGVLKPVEGKKEDPAHPAIHPTgeIPSQELS 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 428 GDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEM 507
Cdd:TIGR01057 378 KDEKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYHYSKFEEKELPPLDRGDKIKVVRVDV 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 508 VDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPghLGMGLVEGYDSMGYEMSKPDLRAE 587
Cdd:TIGR01057 458 RVKETQPPARYDKASLIREMESRGLGTKATRARIIETLYKRGYIEGKKSIKVTP--LGEAVIETLQRYCPEIISEELTRR 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 588 LEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAvakAKKLDEAlaqyfgnGTELA---QQEDIypampepIRKCPQCNKD 664
Cdd:TIGR01057 536 FESKLEDIMSGRITKDEVIDEAKKRLRKILEEF---KKRLDDI-------GIELGkslGSVEV-------VGKCPKCGGK 598
|
650 660
....*....|....*....|.
gi 10835218 665 MVLKTKKNGGFYLsCMGFPEC 685
Cdd:TIGR01057 599 LVSKYAKKGRFVG-CSNYPEC 618
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
35-686 |
1.40e-76 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 264.93 E-value: 1.40e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 35 KVLCVAEKNDAAKGIADLLSNGRMRRReglsKFN-KIYEFDYhlYGQNVtmVMTSVSGHL--LAHD------FQMQFRkw 105
Cdd:PRK05776 2 YILVIAEKPKAARKIAEALSEKPIRCR----IYGvPYWIVKR--DGKKI--VVAPAAGHLfgLHTKskgfpvFDYEWK-- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 106 qscnPLvlFEAEIEKYCPENFVDIKKTLERETRQcqaLVIWTDCDREGENIGFEIIhvcKAVKPNLQVLRARFSEITPHA 185
Cdd:PRK05776 72 ----PL--YEIDKGSKYTKKYYELLSSLSKYADE---FINACDYDIEGSVIGYLII---KYLGDPKKAKRMKFSALTKSD 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 186 VRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLaeqLISYGSCQFPTLGFVVERFKAIQAFVPE 265
Cdd:PRK05776 140 IRRAFRNLETLDYEMINAGIARHELDWLWGINVSRALMSSVRDASGKRV---ILSAGRVQSPTLKYVVEREIERNLFVPL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 266 IFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAK 345
Cdd:PRK05776 217 PYFSVSIIIEKNGYEFTLKYENKKFETKEEAKEILEEIKKTGYLKVTKVEVKIEILEPPPPFNLGDLQVEAARIYGFSPY 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 346 ETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP--TPRNGNKSDQAHPPIHPT-KY 422
Cdd:PRK05776 297 KTQSIAEDLYLDGLISYPRTNSQKLPPTLNIRNILKGLSRSPQYRPLVNLLLKETKGvlKPVQGPKDDPAHPAIYPTgEP 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 423 TNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDI--AQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHF 500
Cdd:PRK05776 377 PKNLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVpgFPLVFSASGQRIEERGWLKYYPFHKFDEEELPLLKKGERV 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 501 QPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYvgLTPDKRFL-PGHLGMGLVEGYDSMGYEM 579
Cdd:PRK05776 457 KIVDVKVRKSYTKPPSRYSKASLLKWMESVGIGTEATRARIIETLFKRGY--LTSNGKYIeVTPLGFGVAEVLEKYFPDI 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 580 SKPDLRAELEADLKLICDGKkdkfvVLRQQVqkykqvfieaVAKAKK-LDEALAQYFGN----GTELAQqediYPAMPEP 654
Cdd:PRK05776 535 VSVELTRDFEEKLEMIRTGK-----ATREEV----------IEEAKEtLNKLLEEFKKNkdeiGEELAK----ALGLIKP 595
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 10835218 655 IRKCPQCNKDMV--------LKTKKNggfYLSCMGFPECR 686
Cdd:PRK05776 596 VGKCKICGREAYkdglckyhYEAKKR---LVKAYEEWKER 632
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
35-685 |
1.09e-62 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 225.43 E-value: 1.09e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 35 KVLCVAEKNDAAKGIADLLsnGRMRRREGlskfnkiyefdyHLYGQNVtmVMTSVSGHLLAH----DFQMQFRKWQ-SCN 109
Cdd:PRK07726 1 MRLFIAEKPSVGRDIADVL--KPHKKGDG------------YIEGNGY--IVTWAIGHLLELaepeAYDERYKRWRlEDL 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 110 PLVlfeaeiekycPENF--VDIKKT------LERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPnlqVLRARFSEI 181
Cdd:PRK07726 65 PII----------PEKWklVVKKKTakqfnvVKKLLKQATEIVIATDADREGELIAREILDYCGVRKP---IKRLWISSL 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 182 TPHAVRTACENL-----TEPdqrVSDAVDVRQELDLRIGAAFTRFQTLRLQRI-FPEVLaeqliSYGSCQFPTLGFVVER 255
Cdd:PRK07726 132 TDKAIKRAFANLkpgkeTIP---LYYSALARSRADWLVGINMTRAYTLLGRKAgYNGVL-----SVGRVQTPTLALVVRR 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 256 FKAIQAFVPEIFHRIKVTHDHKDGIvEFNW--------KRHRLFNHTACLVLYQLCVEDPmATVVEVRSKPKSKWRPQAL 327
Cdd:PRK07726 204 DEEIENFVPKPYWEVEAHLTPGERF-TAKWqpsepyqdEEGRLLDRPLAEQVVARIQGQP-AKVTEVETKRKKEYAPLLY 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 328 DTVELEKLASRKLRINAKETMRIAEKLY-TQGYISYPRTETNIFPRDLNLTVlveqqtPD-----PRWGAFAQSILERGG 401
Cdd:PRK07726 282 DLSELQIDANKRFGLSAKETLDIAQSLYeTHKLITYPRTDSRYLPEDMVATL------PEvlnaiSKVDPYLLLAPPVLD 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 402 PTPRNG---NKSDQAHPPIHPTKYT---NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILAR 475
Cdd:PRK07726 356 PSIRSRawnDKKVTAHHAIIPTEQPpnlSKLSEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEA 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 476 NYLDVYPYDHWSDK---ILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALM-----------------EKHGIGTD 535
Cdd:PRK07726 436 GWKALLGKKEEDEEkeqPLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLLSAMeniarfvqdkelkktlkETDGLGTE 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 536 ATHAEHIETIKARMYvgLTPDKRFL-PGHLGMGLVegyDSMGYEMSKPDLRAELEADLKLICDGKKDkfvvlrqqvqkyK 614
Cdd:PRK07726 516 ATRAGIIEKLFKRGY--LEKKGKYIhATDKGKQLI---DALPEELTSPDMTAKWEQALDQISEGQLS------------Y 578
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10835218 615 QVFI-EAVAKAKKLdeaLAQYfgngtelAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFyLSCMGFPEC 685
Cdd:PRK07726 579 QDFMqPLKQWLKQL---VEQA-------KQSSEKYKFDNLTGPKCPDCGKPMLKVKGKNGKM-LVCQDRECG 639
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
131-708 |
3.54e-49 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 186.22 E-value: 3.54e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 131 KTLERETRQCQALVIWTDCDREGENIGFEIIHVCK-AVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQE 209
Cdd:PRK06599 65 DALKKAAKKADAVYLATDPDREGEAIAWHIAEVLKeAKLKDKNVKRVVFNEITKKAVQEAIENPRDIDMDLVDAQQARRA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 210 LDLRIGAAFTRFqtlrLQRIFPEVLaeqliSYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDG------IVEF 283
Cdd:PRK06599 145 LDYLVGFKLSPL----LWKKVRRGL-----SAGRVQSVALRLICEREDEIEAFIPQEYWTIEADLATSNGepftakLVEV 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 284 NWKR---HRLFNHTACLVLYQLcVEDPMATVVEVRSKPKSKwRPQA-LDTVELEKLASRKLRINAKETMRIAEKLY---- 355
Cdd:PRK06599 216 NGKKlekFSITNEEQAKALVKA-LEGQAYTVDKIEKKERKR-NPPPpFITSTLQQEASRKLGFSAKKTMRIAQKLYegid 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 356 ----TQGYISYPRTETnifprdlnlTVLVEQQTPDPRwgafaQSILERGGP-----TPR---NGNKSDQ-AHPPIHPT-- 420
Cdd:PRK06599 294 lgegTVGLITYMRTDS---------VRLSNEALDEAR-----KYITKKYGKeylpaKPRvykKKSKNAQeAHEAIRPTsi 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 421 KYT-----NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFV--AHGLMILARNYLDVYPYD-----HWSD 488
Cdd:PRK06599 360 NRTpeslkPYLTPDQFKLYELIWKRTVASQMAPAILDQTSVDIASENGKYVfrATGSVILFPGFLKVYGESkddeeEDDE 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 489 KILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGMG- 567
Cdd:PRK06599 440 KLLPPLKEGEKLKLDELLPEQHFTEPPPRYSEASLVKKLEEYGIGRPSTYASIISTLQDREYVELE-KKRFIPTDLGRIv 518
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 568 ---LVEGY-DSMGYemskpDLRAELEADLKLICDGKKDKFVVLRQQVQKykqvFIEAVAKAKKLDEalaqyfgngTELAQ 643
Cdd:PRK06599 519 ndfLVEHFpKYVDY-----DFTAGLEDELDEIAEGKKDWKPVLREFWEP----FISNLEKVEEDVR---------TEKVT 580
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10835218 644 QEDIYpampepiRKCPQCN-KDMVLKTKKNGGFyLSCMGFPECRSAVWLPDS-----VLEASRDSSVCPVC 708
Cdd:PRK06599 581 QEETD-------ETCPKCGgGPLVLKLGKNGKF-LGCSGYPECKYTKNITRDedepiEEEEIVEEEKCPKC 643
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
35-193 |
4.74e-48 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 167.80 E-value: 4.74e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 35 KVLCVAEKNDAAKGIADLLSNGRMRRREGlskfnkiyeFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPL--V 112
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILGGGSKKKGKG---------RYYEFYGEGGGYVVTWASGHLLELDFPEEYDPWDKVWPLedP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 113 LFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKpNLQVLRARFSEITPHAVRTACEN 192
Cdd:cd03362 72 LFPAPFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVK-RKPVKRAWFSSLTPKAIRRAFKN 150
|
.
gi 10835218 193 L 193
Cdd:cd03362 151 L 151
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
147-738 |
1.62e-47 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 183.46 E-value: 1.62e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 147 TDCDREGENIGFEIIHVCKavKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGaaFTrfqtlrl 226
Cdd:PRK07561 94 TDPDREGEAIAWHLLEVLG--GDDVPVKRVVFNEITKNAIQEAFENPRELDINLVNAQQARRFLDRLVG--YM------- 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 227 qrIFPeVLAEQL---ISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGI------VEFNWKRHRLF---NHT 294
Cdd:PRK07561 163 --VSP-LLWKKIargLSAGRVQSVAVRLIVEREREIEAFVPEEYWDIHADLTTPRGDafearlTHLDGKKFAPVdllNEA 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 295 ACLVLYQLcVEDPMATVVEVRSKPKSKwRPQA-LDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTE-TNIFP- 371
Cdd:PRK07561 240 QAEAAVAA-LEGARYSVASVEDKPTTR-KPSApFTTSTLQQEASRKLGFSVKKTMRIAQRLYEAGYITYMRTDsTNLSQe 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 372 -----RDLnltvlveqqtpdprwgafaqsILERGG-----PTPRN-GNKSD---QAHPPIHPT------KYTNNLQGDEQ 431
Cdd:PRK07561 318 ainaaRGY---------------------IGDNYGkkylpEKPRQySSKAKnaqEAHEAIRPSdvfrtpDQLKGLEGDAQ 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 432 RLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYP-----YDHWSDKILPVYEQGSHFQPSTVE 506
Cdd:PRK07561 377 RLYELIWKRFVASQMAPARYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVegrddALDDEDRRLPALKVGDALTLEKLD 456
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 507 MVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVglTPDK-RFLPGHLGM---GLVEGY--DSMGYems 580
Cdd:PRK07561 457 PTQHFTKPPARYSEASLVKELEKLGIGRPSTYASIISTIQDRGYV--RLENrRFYPEKMGRivtDRLEEFfpRLVDY--- 531
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 581 kpDLRAELEADLKLICDGKKDKFVVLRqqvQKYKQvFIEAVAKAKKLDEAlaqyfgNGTELAQqediypaMPEPIRKCPQ 660
Cdd:PRK07561 532 --DFTARMEEELDDIANGEADWKPVLD---DFYKD-FSQQLEKAEELREE------GGMRPNQ-------MVITDRDCPT 592
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 661 CNKDMVLKTKKNGGFyLSCMGF---PECR---------SAVWLPDSVLEASRDSSVCPVCQpHPVYRLKLKF-------- 720
Cdd:PRK07561 593 CGRGMGIRTGKTGVF-LGCSGYalkERCKttrnltpeeETLNVLEGEDAETRALGADPECG-TAMVLRSGRFgpyvqege 670
|
650 660
....*....|....*....|..
gi 10835218 721 ----KRGSLPPTMPLEfvcCIG 738
Cdd:PRK07561 671 gdkpRRLSLPKGNNPE---CVG 689
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
35-193 |
1.06e-40 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 146.60 E-value: 1.06e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 35 KVLCVAEKNDAAKGIADLLSNGRMRRREglskfnkiyefdyhlYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLF 114
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKILGKGSKKKGF---------------YGEGGGYVVTASVGHLLELPFPEEYVDWDKDWPLELF 65
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 10835218 115 EAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAvkPNLQVLRARFSEITPHAVRTACENL 193
Cdd:cd01028 66 PFEPKYVVIPDKKKQLKALKKLAKKADEIVLATDPDREGELIAWEILEVLKC--DNKPVKRAWFSEITPKAIREAFKNL 142
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
35-629 |
4.92e-39 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 157.14 E-value: 4.92e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 35 KVLCVAEKNDAAKGIADLLSngrmrrreGLSKFNKIYEFDYHlygqnvtmVMTSVSGHLLA----HDFQMQFRKWQSCNP 110
Cdd:PRK08173 3 KALIIAEKPSVANDIARALG--------GFTKHDEYFESDEY--------VLSSAVGHLLEiaapEEYEVKRGKWSFAHL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 111 LVLfeaeiekycPENF--VDIKKTLER--------ETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPnlqVLRARFSE 180
Cdd:PRK08173 67 PVI---------PPHFdlNPIAKTESRlkvltkliKRKDVTRLINACDAGREGELIFRLIAQHAKAKKP---VKRLWLQS 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 181 ITPHAVRTACENLTEPDQRVS--DAVDVRQELDLRIGAAFTRFQTLRLQRI--FpevlaeQLISYGSCQFPTLGFVVERF 256
Cdd:PRK08173 135 MTPQAIRDGFANLRSDEDMQPlaDAARCRSEADWLVGINGTRAMTAFNSKGggF------FLTTVGRVQTPTLSIVVERE 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 257 KAIQAFVPEIFHRIKVTHDHKDGIVEFNW-------------KR-HRLFNHTACLVLYQLCvEDPMATVVEvRSKPKSKW 322
Cdd:PRK08173 209 EKIRRFVPRDYWEVRAEFVAAAGFYEGRWfdpkfkkdefdpeKRaSRLWSEAAAEAIVAAC-RGKPGTVTE-ESKPSTQL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 323 RPQALDTVELEKLASRKLRINAKETMRIAEKLYTQ-GYISYPRTETNIFPRDLNLTVL--VEQQTPDPRWGAFAQSILER 399
Cdd:PRK08173 287 SPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDSRALPEDYLGTVKqtLEMLKESNNYLPHAKQILDK 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 400 G--GPTPR---NGNKSDqaHPPIHPTKYT-NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMIL 473
Cdd:PRK08173 367 GwvKPNKRifdNSKISD--HFAIIPTLQApKSLSEPEQKLYDLVVKRFLAVFFPAAEFLVTTRITEVAGHHFKTEGKVLV 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 474 ARNYLDVYPYD-HWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALME----------------KHGIGTDA 536
Cdd:PRK08173 445 NPGWLAVYGKEaQGADANLVPVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEgagklveddelreamaEKGLGTPA 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 537 THAEHIETIKARMYV-----GLTPD-KRFlpgHLgMGLVEGYDSMgyEMSKPDLRAELEADLKLICDGKKDKFVVLRQQV 610
Cdd:PRK08173 525 TRAAIIEGLLGEKYLvregrELIPTaKAF---QL-MTLLRGLGVE--ELTSPELTGEWEYKLSQIERGKLSRDAFMQEIA 598
|
650
....*....|....*....
gi 10835218 611 QKYKQVfieaVAKAKKLDE 629
Cdd:PRK08173 599 QMTQQI----VKRAKEYDS 613
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
133-715 |
9.17e-37 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 149.59 E-value: 9.17e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 133 LERETRQCQALVIWTDCDREGENIGFeiiHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDL 212
Cdd:PRK06319 67 ICKLAKKCDVVYLSPDPDREGEAIAW---HIANQLPKNTKIQRISFNAITKGAVTEALKHPREIDMALVNAQQARRLLDR 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 213 RIGAAFTRFQTLRLQRifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKV-THDHKDG------IVEFNW 285
Cdd:PRK06319 144 IVGYKISPILSRKLQR-------RSGVSAGRVQSVALKLVVDREKAIEAFVPVEYWNIRVhLKDPKTQktfwahLYSVDG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 286 KRHR-------------LFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAE 352
Cdd:PRK06319 217 KKWEkeipegktedevlLINSKEKADHIVELLESATYTVTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSSRTMNIAQ 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 353 KLY---------TQGYISYPRTET-NIFPRDLNLTVLVEQQTpdprwgaFAQSILERGgPTPRNGNKSDQ-AHPPIHPT- 420
Cdd:PRK06319 297 TLYegvdldsegATGLITYMRTDSvRTDPEALKQVRKYIEGT-------FGKEFLPSS-PNVYTTKKMAQdAHEAIRPTd 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 421 ------KYTNNLQGDEQRLYEFIVRHFLAccSQDAQGQETTVEIDIAQERFV---AHGLMILARNYLDVYP------YDH 485
Cdd:PRK06319 369 itltpeKLRSKLTEDQYKLYSLIWKRFVA--SQMIPAIYDTLAIRITTNKGIdlrATGSLLKFKGFLAVYEekrddeGDE 446
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 486 WSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVgLTPDKRFLPGHLG 565
Cdd:PRK06319 447 EENIHLPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYT-LKENQRLRPTELG 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 566 MGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKA----------------KKLDE 629
Cdd:PRK06319 526 KIISQFLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQEFWELFLPVVVTAEKEAfiprivteidcpkchkGKLVK 605
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 630 ALAQ---YFG-----------NGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFyLSCMGFPECRSAVWLPDSV 695
Cdd:PRK06319 606 IWAKnryFYGcseypecdyktSEEELTFNKEDYAEDTPWDSPCPLCGGEMKVRHGRFGTF-LGCENYPECRGIINIHKKG 684
|
650 660
....*....|....*....|....
gi 10835218 696 LEAS--RDSSVCPV--CQPHPVYR 715
Cdd:PRK06319 685 EEGIepEETVPCPAigCTGHIVKR 708
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
35-628 |
7.71e-34 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 140.86 E-value: 7.71e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 35 KVLCVAEKNDAAKGIADLLSngrmrrrEGLSKFNKIYEfdyhlYGQNVTMVMTSVSGHLL----AHDFQMQFRKWQSCNP 110
Cdd:PRK14724 2 KTLVIAEKPSVAQDIVRALT-------PVAGKFEKHDE-----HFESDSYVVTSAVGHLVeiqaPEEFDVKRGKWSFANL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 111 LVLfeaeiekycPENFvDIKKTLERETR-----------QCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQ--VLRAR 177
Cdd:PRK14724 70 PVI---------PPYF-DLKPVDKTKTRlnavvklakrkDVTELVNACDAGREGELIFRLIEQYAGGAKGGLGkpVKRLW 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 178 FSEITPHAVRTACENLTEPDQR--VSDAVDVRQELDLRIGAAFTRFQTLRLQR---IFpevlaeqLISYGSCQFPTLGFV 252
Cdd:PRK14724 140 LQSMTPQAIRDGFDNLRSDAQMqgLASAARSRSEADWLVGINGTRAMTAFNSRdggFF-------LTTVGRVQTPTLSLV 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 253 VERFKAIQAFVPEIFHRIKVTHDHKDG-----IVEFNWKRH---------RLFNHTACLVLYQlCVEDPMATVVEvRSKP 318
Cdd:PRK14724 213 VEREEKIRKFVSRDYWEIHAGFHAEAGeylgkWFDPQWKKAsddpearadRVWSEREARAIAD-AVRGKAATVTE-ESKP 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 319 KSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQ-GYISYPRTETNIFPRDLnltVLVEQQTPDPRWGA------ 391
Cdd:PRK14724 291 TTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDY---LPVAKQTFEMLATSgmrhla 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 392 -FAQSILERG--GPTPR---NGNKSDqaHPPIHPT-KYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQER 464
Cdd:PRK14724 368 pFAQQALDGNyvRPSKRifdNSKVSD--HFAIIPTtQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHS 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 465 FVAHGLMILARNYLDVYPYDHWSD-----------KILPVyEQGSHFQPSTVEMVDGETSPPKLLTEADLIALME----- 528
Cdd:PRK14724 446 FKTEGKVLVKPGWLAIYGKEAANEvedakdgdkgqPLVPV-KPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMEsagkq 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 529 -----------KHGIGTDATHAEHIETIKARMYVgLTPDKRFLPGHLG---MGLVEGYDSMgyEMSKPDLRAELEADLKL 594
Cdd:PRK14724 525 idddelreamqEKGLGTPATRAAIIEGLLTEKYM-LREGRELIPTAKAfqlMTLLRGLGVE--ELSRAELTGEWEYKLAQ 601
|
650 660 670
....*....|....*....|....*....|....*.
gi 10835218 595 ICDGK--KDKFVvlrQQVQKYKQvfiEAVAKAKKLD 628
Cdd:PRK14724 602 MEKGQlsREAFM---QQIAAMTE---KLVKKAKEYD 631
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
95-608 |
4.26e-32 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 134.50 E-value: 4.26e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 95 AHDFQMQFrkwqscnplvlfeAEIEKycPENFVD-IKKTLeretRQCQALVIWTDCDREGENIGFEIIHVCK--AVKPNL 171
Cdd:PRK08780 47 ENGFAMRY-------------DLIDK--NEKHVEaIAKAA----KSADDLYLATDPDREGEAISWHLAEILKerGLLKDK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 172 QVLRARFSEITPHAVRTACENltePDQRVSDAVDVRQE---LDLRIGAAFTRFQTLRLQRifpevlaeqLISYGSCQFPT 248
Cdd:PRK08780 108 PMQRVVFTEITPRAIKEAMAK---PRDIASDLVDAQQArraLDYLVGFNLSPLLWRKIQR---------GLSAGRVQSPA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 249 LGFVVERFKAIQAFVPEIFHRIKVTHDHKDGivEFNWKRHRLFNH-----------TACLVLYQLC-VEDPMATVVEVRS 316
Cdd:PRK08780 176 LRMIVEREEEIEAFIAREYWSIEADCAHPSQ--PFNAKLIKLDGQkfeqftitdgdTAEAARLRIQqAAQGTLHVTDVES 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 317 KPKsKWRPQA-LDTVELEKLASRKLRINAKETMRIAEKLY---------TQGYISYPRTETnifprdLNLTVLVEQQTPD 386
Cdd:PRK08780 254 KER-KRNPAPpFTTSTLQQEASRKLGFTTRRTMQVAQKLYegvdlgdegSVGLITYMRTDS------VNLSQDALAEIRD 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 387 PRWGAFAQSILERGGPTPRNGNKSDQ-AHPPIHPT-------KYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEI 458
Cdd:PRK08780 327 VIARDYGTASLPDQPNTYKTKSKNAQeAHEAVRPTsalrtpaQVARFLSDDQRRLYELIWKRAVACQMIPATLNTVSVDL 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 459 DIAQER-FVAHGLMILARNYLDVY--------PYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEK 529
Cdd:PRK08780 407 AAGSEHvFRATGSTVVVPGFLAVYeegkddksAEDEDEGRKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKALEE 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 530 HGIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGMG----LVEGYDS-MGYemskpDLRAELEADLKLICDGKKDKFV 604
Cdd:PRK08780 487 YGIGRPSTYASIISTLQFRKYVEME-GRRFRPTDVGRAvnkfLTGHFTRyVDY-----DFTARLEDDLDAVSRGEKEWIP 560
|
....
gi 10835218 605 VLRQ 608
Cdd:PRK08780 561 LMEK 564
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
173-268 |
6.84e-32 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 119.22 E-value: 6.84e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 173 VLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevlaeQLISYGSCQFPTLGFV 252
Cdd:smart00436 1 IKRIEFSEITKKAIREALKNPREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRN--------GVLSAGRVQTPTLGLI 72
|
90
....*....|....*.
gi 10835218 253 VERFKAIQAFVPEIFH 268
Cdd:smart00436 73 VEREREIKNFVPKPYW 88
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
128-723 |
3.83e-24 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 108.80 E-value: 3.83e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 128 DIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVR 207
Cdd:COG0551 72 KKLKKDKKKKAKALAAALAAADDDAIEAAAAADEEEALKAAEALEAIRKAVVEEVKSRARKRAARAPADVAAAAAAAALA 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 208 QELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFptLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKR 287
Cdd:COG0551 152 RLLLLAAASRALRLLLLLAAGRLRLLSAVAAGLLELEEL--LKEFEEEEEEEAAEEEEEEEEAKKKKEEDKKKKKKKKKK 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 288 HRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKET------MRIAEKLYTQGYIS 361
Cdd:COG0551 230 DKEEETKAIKKKKKAAEAVLAAKKAAKEAKAKKELPTTTTDALPEALATTSLTAAAAASAlaaallEEEGELLYTGGYIR 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 362 YPRTETNIFPRDLNLTVLVEQQTPDPrWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNN---LQGDEQRLYEFIV 438
Cdd:COG0551 310 YTRTPKSSEADALAALEALKKIAEEP-PDERAKKKKKKAKKKKASEAKETTDHPPIPPTTAAALlelLEDRKLLLELLVR 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 439 RHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLL 518
Cdd:COG0551 389 RRFAAAADLAKVEELTKVEEADEEELVEAEGGLLEVLGEEEEDDEDEEEELLLPPLEEGEPLLLEELLLEKQTTTPPPRY 468
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 519 TEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDG 598
Cdd:COG0551 469 TTELLLKKLEEEGGGGRGTTATIIILILKRRYVVLEEKKTTPTELLVEVVLLLLLPFPKLEDTTETAEEEEALLDKEEGK 548
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 599 KKDKFVVLRqqvqKYKQVFIEAVAKAKKldealaqyfgngtelaQQEDIYPAMPEPI-RKCPQCNKDMVLKTKKNGGFyL 677
Cdd:COG0551 549 EDKVVEIRE----EEYPFFKKLLEIAEE----------------EGEEELSEEDEVLgEKCPKCGKPLVIKKGRYGKF-L 607
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 10835218 678 SCMGFPECRSAvwLPdsvLEASRDSSV-CPVCQphpVYRLKLKFKRG 723
Cdd:COG0551 608 GCSNYPECKYT--KP---LPKPEVTGVkCPKCG---KKLVLRKSKKG 646
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
895-939 |
9.60e-19 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 80.53 E-value: 9.60e-19
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 10835218 895 TSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDEN 939
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGREKQCGFFQWADEV 45
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
811-852 |
5.64e-17 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 75.52 E-value: 5.64e-17
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 10835218 811 VTCNCGQEAVLLTVRKEGPNRGRQFFKCNGG---SCNFFLWADSP 852
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGrekQCGFFQWADEV 45
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
655-694 |
4.51e-12 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 61.12 E-value: 4.51e-12
10 20 30 40
....*....|....*....|....*....|....*....|
gi 10835218 655 IRKCPQCNKDMVLKTKKNGGFYlSCMGFPECRSAVWLPDS 694
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFV-GCSNYPECRFTRPLKKN 39
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
36-181 |
1.53e-09 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 55.83 E-value: 1.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 36 VLCVAEKNDAAKGIADLLSNGrmrrreglskfnkiyefdyhlygqnvTMVMTSVSGHLLAHDFqmqfrkwqscnplvlfe 115
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGGG--------------------------FQAVVAVLGHLLSLEK----------------- 37
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10835218 116 aeiekycpENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPnlQVLRARFSEI 181
Cdd:pfam01751 38 --------GPKKKALKALKELALKAKEVILATDPDREGEAIALKLLELKELLEN--AGGRVEFSEL 93
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
131-192 |
7.48e-09 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 54.87 E-value: 7.48e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10835218 131 KTLERETRQCQALVIWTDCDREGENIGFeiiHVCKAVKPNLQVLRARFSEITPHAVRTACEN 192
Cdd:cd03363 64 KELKKLAKKADEIYLATDPDREGEAIAW---HLAEVLKLKKNVKRVVFNEITKEAIKEALKN 122
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
129-570 |
3.44e-08 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 57.64 E-value: 3.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 129 IKKTLER----ETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQV--LRARFSEITPHAVRTACE--NLTEPDQRV 200
Cdd:PTZ00407 110 IQETLERyieeKADNVTEIILATDPDREGELIAVHALQTIKRLYPKLKVpfSRAYMHSITEDGIRKAMRerHVEACDYDL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 201 SDAVDVRQELDlRI----GAAFTRFQTlrlqrifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFV------------- 263
Cdd:PTZ00407 190 ANAAETRHAMD-RIfgflGSSVVRAAN------------SQMRSIGRVQTPALILINEREDKIKAFLesnkstfevqamc 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 264 --PEIFHR-----IKVTHDHKDGIVEFNWK---RHRLfNHTACLVLYQLCVEdPMATVVEVRSKPkskwrPQALDTVELE 333
Cdd:PTZ00407 257 qfPSPHGTtfsqvVTITPDRKGGASHWATEaeaRRCL-EQWKLNNCTGFSVP-LEPKPQPSVVPP-----PQPFTMATAI 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 334 KLASRKLRINAKETMRIAEKLYTQGYISYPRTET-----NIFP----------------RDLNLTVLVEQQTPDPRWGAF 392
Cdd:PTZ00407 330 AKANRQLKYSSEMVSGCLQDLFQLGHITYPRTDStrideSALPdiyaavkkefgkeflyRLEDRTVSAQEGKGSKKTGKK 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 393 AQSILERGGPTPRnGNKSDqAHPPIHPTKYtnNLQGDE-------QRLYEFIVRHFLA----------------CCSqdA 449
Cdd:PTZ00407 410 RSTKQKKGADTPV-GNVED-AHEAIRPTNI--DTTGESlslspptRAVYDLVRRNTLAvfmipmktekivatvkFTS--G 483
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 450 QGQETTVEI-------------------------------------------DIAQERFVAhgLMILARnyldvypydhw 486
Cdd:PTZ00407 484 SGEKLEFELqgkrvvepgwtrafhkgdkgttgpaeetdeditaveegapvvpSLSQEEFKA--IMNLRS----------- 550
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 487 sdkILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGM 566
Cdd:PTZ00407 551 ---QLGSGVQKGFFELRSPQVRENRPVPPLPHSEGTLIEELKNNGVGRPSTYPMIVKTLLARGYIAVNPKGRCETTPVGR 627
|
....
gi 10835218 567 GLVE 570
Cdd:PTZ00407 628 MLVE 631
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
128-168 |
9.91e-07 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 47.26 E-value: 9.91e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 10835218 128 DIKKTLERETRQCQaLVIWTDCDREGENIGFEIIHVCKAVK 168
Cdd:smart00493 36 EQIKLLKKLAKKAE-VILATDPDREGEAIAWELAELLKPAG 75
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
125-175 |
2.77e-05 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 43.57 E-value: 2.77e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 10835218 125 NFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLR 175
Cdd:cd00188 32 ALNKTRELLKRLLGEAKEVIIATDADREGEAIALRLLELLKSLGKKVRRLL 82
|
|
| COG1754 |
COG1754 |
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]; |
309-732 |
7.80e-04 |
|
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
Pssm-ID: 441360 [Multi-domain] Cd Length: 892 Bit Score: 43.65 E-value: 7.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 309 ATVVEVRSKPKSKWRPQAldtvelEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR 388
Cdd:COG1754 256 AAAAAVREPPTPTTTTTA------QAATTTTTRAAAARTTRSAQQAARRTRLGGEGTYTTTTTTTTTTSAAAAAAAAAAA 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 389 WGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYT----------NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEI 458
Cdd:COG1754 330 ALAAAAAAAYAPPPPYYYKKKAAAAAAAAAAAAAAaarrppaaraALLSDDRLLLELLLLRRTAAAAAAAAAATATTTAA 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 459 DIAQE----------RFVAHGLMILARNYLDVYPYDHwSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALME 528
Cdd:COG1754 410 AAAAGagavgtaaagAVFFFGGFLLFAEEEDDDEEDD-DDDDLPALEEGLPLLKEGVLADQHFTQPPPRYTEAPLVKRME 488
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 529 KHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGhlGMGLV------------EGYdsmgyemskpDLRAELEADLKLIC 596
Cdd:COG1754 489 ELGIGRPSTYASILSTLADRIYVRLD-KRRLIPE--DKGRLvtaflfsffrryVEY----------DFTADLEEFLDDVS 555
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 597 DGKKDKFVVLRQQVQKYKQvFIEAVAKAKKLDEALAqyfgngteLAQQEDIypaMPEPIRKCPQCNKDMVLKTKKNGGfY 676
Cdd:COG1754 556 DGELDWKAVLRRFWRDFSA-AYDETGDLRISEVLDA--------LEDLGEI---DPREINSCPLGTGGLSLRVGRYGP-F 622
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835218 677 LSCMG-------FPECRSavwlPDS-VLEASRDSSVCPVCQP----------HPVYRLKLKF-----------------K 721
Cdd:COG1754 623 IECSNyeprrasIPECLA----PDElTPEKAEELLEAPADGPrvlgtdpetgKPIVLKDGRFgpyvqlgepekedkpkpK 698
|
490
....*....|.
gi 10835218 722 RGSLPPTMPLE 732
Cdd:COG1754 699 RASLPKGMSPE 709
|
|
| |
