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Conserved domains on  [gi|4758774|ref|NP_004539|]
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NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [Homo sapiens]

Protein Classification

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10( domain architecture ID 6427)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 is an accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I

Gene Ontology:  GO:0005747|GO:0032981

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDUFB10 super family cl10933
NADH-ubiquinone oxidoreductase subunit 10; NDUFB10 is a family of conserved proteins of up to ...
 36-161 4.73e-50

NADH-ubiquinone oxidoreductase subunit 10; NDUFB10 is a family of conserved proteins of up to 180 residues. It is one of the 41 protein subunits within the hydrophobic fraction of the NADH:ubiquinone oxidoreductase (complex I), a multiprotein complex located in the inner mitochondrial membrane whose main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. NDUFB10 is encoded in the nucleus.


The actual alignment was detected with superfamily member pfam10249:

Pssm-ID: 431170  Cd Length: 126  Bit Score: 157.01  E-value: 4.73e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758774     36 DRPVTLVRE-FIERqhAKNRYYYYHRQYRRVPDITECKEEDIMCMYEAEMQWKRDYKVDQEIINIMQDRLKACQQREGQN 114
Cdd:pfam10249   1 DKPVTWFREkIVEP--NRKKYYYYHQKFRRVPTIDECYTDDYVCYYEANMQWKRDKLVDQEILKILRQRLEDCQQYEGPD 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 4758774    115 YQQNCIKEVEQFTQVAKAYQDRYQDLGAYSSARKCLAKQRQRMLQER 161
Cdd:pfam10249  79 YVQNCAKLKKQYEEAATNYFIKYGDLGAYGNARKAYMKQKHRMIWER 125
 
Name Accession Description Interval E-value
NDUFB10 pfam10249
NADH-ubiquinone oxidoreductase subunit 10; NDUFB10 is a family of conserved proteins of up to ...
 36-161 4.73e-50

NADH-ubiquinone oxidoreductase subunit 10; NDUFB10 is a family of conserved proteins of up to 180 residues. It is one of the 41 protein subunits within the hydrophobic fraction of the NADH:ubiquinone oxidoreductase (complex I), a multiprotein complex located in the inner mitochondrial membrane whose main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. NDUFB10 is encoded in the nucleus.


Pssm-ID: 431170  Cd Length: 126  Bit Score: 157.01  E-value: 4.73e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758774     36 DRPVTLVRE-FIERqhAKNRYYYYHRQYRRVPDITECKEEDIMCMYEAEMQWKRDYKVDQEIINIMQDRLKACQQREGQN 114
Cdd:pfam10249   1 DKPVTWFREkIVEP--NRKKYYYYHQKFRRVPTIDECYTDDYVCYYEANMQWKRDKLVDQEILKILRQRLEDCQQYEGPD 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 4758774    115 YQQNCIKEVEQFTQVAKAYQDRYQDLGAYSSARKCLAKQRQRMLQER 161
Cdd:pfam10249  79 YVQNCAKLKKQYEEAATNYFIKYGDLGAYGNARKAYMKQKHRMIWER 125
 
Name Accession Description Interval E-value
NDUFB10 pfam10249
NADH-ubiquinone oxidoreductase subunit 10; NDUFB10 is a family of conserved proteins of up to ...
 36-161 4.73e-50

NADH-ubiquinone oxidoreductase subunit 10; NDUFB10 is a family of conserved proteins of up to 180 residues. It is one of the 41 protein subunits within the hydrophobic fraction of the NADH:ubiquinone oxidoreductase (complex I), a multiprotein complex located in the inner mitochondrial membrane whose main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. NDUFB10 is encoded in the nucleus.


Pssm-ID: 431170  Cd Length: 126  Bit Score: 157.01  E-value: 4.73e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758774     36 DRPVTLVRE-FIERqhAKNRYYYYHRQYRRVPDITECKEEDIMCMYEAEMQWKRDYKVDQEIINIMQDRLKACQQREGQN 114
Cdd:pfam10249   1 DKPVTWFREkIVEP--NRKKYYYYHQKFRRVPTIDECYTDDYVCYYEANMQWKRDKLVDQEILKILRQRLEDCQQYEGPD 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 4758774    115 YQQNCIKEVEQFTQVAKAYQDRYQDLGAYSSARKCLAKQRQRMLQER 161
Cdd:pfam10249  79 YVQNCAKLKKQYEEAATNYFIKYGDLGAYGNARKAYMKQKHRMIWER 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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