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Conserved domains on  [gi|4758460|ref|NP_004479|]
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platelet glycoprotein V precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-299 1.94e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 114.65  E-value: 1.94e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   44 SALGLPTNLTHILLFGmgrgvlqSQSFSGMTVLQRLMISDSHISAVaPGTFSDLIKLKTLRLSRNKITHLPGALlDKMVL 123
Cdd:COG4886  90 TDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPL-GNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  124 LEQLFLDHNALRGIDQNmFQKLVNLQELALNQNQLDFLPASLfTNLENLKLLDLSGNNLTHLPKGlLGAQAKLERLLLHS 203
Cdd:COG4886 161 LKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSN 237

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  204 NRLVSLDSglLNSLGALTELQFHRNHIRSIAPGAfdRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPG 283
Cdd:COG4886 238 NQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313

                       250
                ....*....|....*.
gi 4758460  284 VLFGEMGGLQELWLNR 299
Cdd:COG4886 314 LILLLLLTTLLLLLLL 329
LRRCT smart00082
Leucine rich repeat C-terminal domain;
421-472 5.13e-09

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 52.05  E-value: 5.13e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 4758460     421 NSWRCDCGLGPFLGWLRQhLGLVGGEEPPRCAGPGAHAGlPLWALPGGDAEC 472
Cdd:smart00082   1 NPFICDCELRWLLRWLQA-NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
340-399 4.51e-08

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.51e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460    340 ELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQL 399
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 super family cl38440
Leucine rich repeat;
291-351 1.11e-03

Leucine rich repeat;


The actual alignment was detected with superfamily member pfam13855:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4758460    291 GLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSpRLSALPQGAFQGLGELQVLALHSNGL 351
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-299 1.94e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 114.65  E-value: 1.94e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   44 SALGLPTNLTHILLFGmgrgvlqSQSFSGMTVLQRLMISDSHISAVaPGTFSDLIKLKTLRLSRNKITHLPGALlDKMVL 123
Cdd:COG4886  90 TDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPL-GNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  124 LEQLFLDHNALRGIDQNmFQKLVNLQELALNQNQLDFLPASLfTNLENLKLLDLSGNNLTHLPKGlLGAQAKLERLLLHS 203
Cdd:COG4886 161 LKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSN 237

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  204 NRLVSLDSglLNSLGALTELQFHRNHIRSIAPGAfdRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPG 283
Cdd:COG4886 238 NQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313

                       250
                ....*....|....*.
gi 4758460  284 VLFGEMGGLQELWLNR 299
Cdd:COG4886 314 LILLLLLTTLLLLLLL 329
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
103-382 1.30e-19

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 92.84  E-value: 1.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   103 LRLSRNKITHLPGALLDKMVlleQLFLDHNALRGIDQNMFQklvNLQELALNQNQLDFLPASLftnLENLKLLDLSGNNL 182
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQIT---TLILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATL---PDTIQEMELSINRI 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   183 THLPKGLLGAqakLERLLLHSNRLVSLDSGLLNSLGALTelqFHRNHIRSIApgafDRLPN-LSSLTLSRNHLAFLPSAL 261
Cdd:PRK15370 254 TELPERLPSA---LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTLP----AHLPSgITHLNVQSNSLTALPETL 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   262 flhSHNLTLLTLFENPLAELPGVLFGEmggLQELWLNRTQLRTLPAaafrnlsrlrylgvTLSPrlsalpqgafqglgEL 341
Cdd:PRK15370 324 ---PPGLKTLEAGENALTSLPASLPPE---LQVLDVSKNQITVLPE--------------TLPP--------------TI 369

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 4758460   342 QVLALHSNGLTALPDGLLRGLgKLRQVSlrRNRLRALPRAL 382
Cdd:PRK15370 370 TTLDVSRNALTNLPENLPAAL-QIMQAS--RNNLVRLPESL 407
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 97-230 3.25e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.82  E-value: 3.25e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   97 LIKLKTLRLSRNKITHLPGalLDKMVLLEQLFLDHNALRGIDQnmFQKLVNLQELAL-NQN-----QLDFLPASLFTNLE 170
Cdd:cd21340  45 LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIeNQRlppgeKLTFDPRSLAALSN 120

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4758460  171 NLKLLDLSGNNLTHLpkGLLGAQAKLERLLLHSNRLVSLD--SGLLNSLGALTELQFHRNHI 230
Cdd:cd21340 121 SLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
195-254 1.01e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.01e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460    195 KLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHL 254
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
421-472 5.13e-09

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 52.05  E-value: 5.13e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 4758460     421 NSWRCDCGLGPFLGWLRQhLGLVGGEEPPRCAGPGAHAGlPLWALPGGDAEC 472
Cdd:smart00082   1 NPFICDCELRWLLRWLQA-NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 394-472 2.76e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 57.01  E-value: 2.76e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4758460     394 LDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAEC 472
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC 80
LRR_8 pfam13855
Leucine rich repeat;
340-399 4.51e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.51e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460    340 ELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQL 399
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
291-351 1.11e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4758460    291 GLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSpRLSALPQGAFQGLGELQVLALHSNGL 351
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-299 1.94e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 114.65  E-value: 1.94e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   44 SALGLPTNLTHILLFGmgrgvlqSQSFSGMTVLQRLMISDSHISAVaPGTFSDLIKLKTLRLSRNKITHLPGALlDKMVL 123
Cdd:COG4886  90 TDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPL-GNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  124 LEQLFLDHNALRGIDQNmFQKLVNLQELALNQNQLDFLPASLfTNLENLKLLDLSGNNLTHLPKGlLGAQAKLERLLLHS 203
Cdd:COG4886 161 LKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSN 237

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  204 NRLVSLDSglLNSLGALTELQFHRNHIRSIAPGAfdRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPG 283
Cdd:COG4886 238 NQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313

                       250
                ....*....|....*.
gi 4758460  284 VLFGEMGGLQELWLNR 299
Cdd:COG4886 314 LILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-365 1.74e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.87  E-value: 1.74e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   86 ISAVAPGTFSDLIKLKTLRLSRNKithlpgaLLDKMVLLEQLFLDHNALRGIDQNmFQKLVNLQELALNQNQLDFLPASL 165
Cdd:COG4886  84 LLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPL 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  166 FtNLENLKLLDLSGNNLTHLPKGLLGAQaKLERLLLHSNRLVSLDSGLLNsLGALTELQFHRNHIRSIaPGAFDRLPNLS 245
Cdd:COG4886 156 G-NLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDL-PEPLANLTNLE 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  246 SLTLSRNHLAFLPSalFLHSHNLTLLTLFENPLAELPGvlFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSP 325
Cdd:COG4886 232 TLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4758460  326 RLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKL 365
Cdd:COG4886 308 LNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
127-421 3.86e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 3.86e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  127 LFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRL 206
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  207 VSLDSGLLNSLGALTELQfhrnHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFlHSHNLTLLTLFENPLAELPGVLf 286
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLT----ELDLSGNEELSNLTNLESLDLSGNQLTDLPEELA-NLTNLKELDLSNNQLTDLPEPL- 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  287 GEMGGLQELWLNRTQLRTLPAAaFRNLSRLRYLGVTlSPRLSALPQgAFQGLGELQVLALHSNGLTALPDGLlRGLGKLR 366
Cdd:COG4886 156 GNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS-NNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLE 231

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4758460  367 QVSLRRNRLRALPRalFRNLSSLESVQLDHNQLETLPgdVFGALPRLTEVLLGHN 421
Cdd:COG4886 232 TLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNN 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
117-422 5.83e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.25  E-value: 5.83e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  117 LLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKL 196
Cdd:COG4886   9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  197 ERLLLHSNRLVSLD---SGLLNSLGALTELQFHRNHIRSIaPGAFDRLPNLSSLTLSRNHLAFLPSALFlHSHNLTLLTL 273
Cdd:COG4886  89 LTDLGDLTNLTELDlsgNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDL 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  274 FENPLAELPGVLfGEMGGLQELWLNRTQLRTLPAAaFRNLSRLRYLGVTlSPRLSALPQgAFQGLGELQVLALHSNGLTA 353
Cdd:COG4886 167 SNNQLTDLPEEL-GNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLS-GNQLTDLPE-PLANLTNLETLDLSNNQLTD 242

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4758460  354 LPDglLRGLGKLRQVSLRRNRLRALPRALfrNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNS 422
Cdd:COG4886 243 LPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-404 9.99e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.86  E-value: 9.99e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   81 ISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDF 160
Cdd:COG4886   7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  161 LPASLFTNLENLKLLDLSGNNlthlpkgLLGAQAKLERLLLHSNRLVSLDSGLLNsLGALTELQFHRNHIRSIaPGAFDR 240
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDL-PEPLGN 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  241 LPNLSSLTLSRNHLAFLPSALfLHSHNLTLLTLFENPLAELPGVLfGEMGGLQELWLNRTQLRTLPaAAFRNLSRLRYLG 320
Cdd:COG4886 158 LTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLP-EPLANLTNLETLD 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  321 VTLSpRLSALPQgaFQGLGELQVLALHSNGLTALPDglLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLE 400
Cdd:COG4886 235 LSNN-QLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309


                ....
gi 4758460  401 TLPG 404
Cdd:COG4886 310 LLEL 313
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
103-382 1.30e-19

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 92.84  E-value: 1.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   103 LRLSRNKITHLPGALLDKMVlleQLFLDHNALRGIDQNMFQklvNLQELALNQNQLDFLPASLftnLENLKLLDLSGNNL 182
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQIT---TLILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATL---PDTIQEMELSINRI 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   183 THLPKGLLGAqakLERLLLHSNRLVSLDSGLLNSLGALTelqFHRNHIRSIApgafDRLPN-LSSLTLSRNHLAFLPSAL 261
Cdd:PRK15370 254 TELPERLPSA---LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTLP----AHLPSgITHLNVQSNSLTALPETL 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   262 flhSHNLTLLTLFENPLAELPGVLFGEmggLQELWLNRTQLRTLPAaafrnlsrlrylgvTLSPrlsalpqgafqglgEL 341
Cdd:PRK15370 324 ---PPGLKTLEAGENALTSLPASLPPE---LQVLDVSKNQITVLPE--------------TLPP--------------TI 369

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 4758460   342 QVLALHSNGLTALPDGLLRGLgKLRQVSlrRNRLRALPRAL 382
Cdd:PRK15370 370 TTLDVSRNALTNLPENLPAAL-QIMQAS--RNNLVRLPESL 407
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-316 4.01e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 4.01e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   69 SFSGMTVLQRLMISDSHISAVaPGTFSDLIKLKTLRLSRNKITHLPGALlDKMVLLEQLFLDHNALRGIDQNmFQKLVNL 148
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEP-LANLTNL 230

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  149 QELALNQNQLDFLPAslFTNLENLKLLDLSGNNLTHLPKglLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRN 228
Cdd:COG4886 231 ETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  229 HIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAA 308
Cdd:COG4886 307 LLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLL 386


                ....*...
gi 4758460  309 AFRNLSRL 316
Cdd:COG4886 387 LTLLLLLL 394
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
147-410 1.04e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 80.51  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   147 NLQELALNQNQLDFLPASLftnLENLKLLDLSGNNLTHLPKGLlgaQAKLERLLLHSNRLVSLDSGLLNSLgalTELQFH 226
Cdd:PRK15370 179 NKTELRLKILGLTTIPACI---PEQITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSIPATLPDTI---QEMELS 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   227 RNHIRSIApgafDRLPN-LSSLTLSRNHLAFLPSALflhSHNLTLLTLFENPLAELPGVLfgeMGGLQELWLNRTQLRTL 305
Cdd:PRK15370 250 INRITELP----ERLPSaLQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL---PSGITHLNVQSNSLTAL 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   306 PAAafrnlsrlrylgvtlsprlsaLPQGafqglgeLQVLALHSNGLTALPDGLLRglgKLRQVSLRRNRLRALPRALFRN 385
Cdd:PRK15370 320 PET---------------------LPPG-------LKTLEAGENALTSLPASLPP---ELQVLDVSKNQITVLPETLPPT 368

                        250       260
                 ....*....|....*....|....*
gi 4758460   386 LSSLEsvqLDHNQLETLPGDVFGAL 410
Cdd:PRK15370 369 ITTLD---VSRNALTNLPENLPAAL 390
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
67-306 2.06e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 2.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   67 SQSFSGMTVLQRLMISDSHISAVaPGTFSDLIKLKTLRLSRNKITHLPGALlDKMVLLEQLFLDHNALRGIDQnmFQKLV 146
Cdd:COG4886 175 PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLT 250

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  147 NLQELALNQNQLDFLPASLftNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFH 226
Cdd:COG4886 251 NLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  227 RNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLP 306
Cdd:COG4886 329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALL 408
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 97-230 3.25e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.82  E-value: 3.25e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   97 LIKLKTLRLSRNKITHLPGalLDKMVLLEQLFLDHNALRGIDQnmFQKLVNLQELAL-NQN-----QLDFLPASLFTNLE 170
Cdd:cd21340  45 LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIeNQRlppgeKLTFDPRSLAALSN 120

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4758460  171 NLKLLDLSGNNLTHLpkGLLGAQAKLERLLLHSNRLVSLD--SGLLNSLGALTELQFHRNHI 230
Cdd:cd21340 121 SLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 91-421 4.51e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 78.74  E-value: 4.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460    91 PGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRG-----------------IDQNM-------FQKLV 146
Cdd:PLN00113 181 PNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGeipyeiggltslnhldlVYNNLtgpipssLGNLK 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   147 NLQELALNQNQL-DFLPASLFtNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQF 225
Cdd:PLN00113 261 NLQYLFLYQNKLsGPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQL 339

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   226 HRNHIRSIAPGAFDRLPNLSSLTLSRNHLA-FLPSALfLHSHNLTLLTLFENPL-AELPGVLfGEMGGLQELWLNRTQLR 303
Cdd:PLN00113 340 WSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGL-CSSGNLFKLILFSNSLeGEIPKSL-GACRSLRRVRLQDNSFS 417

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   304 --------TLPAAAFRNLSRLRYLGvTLSPRLSALPQgafqglgeLQVLALHSNGLTA-LPDglLRGLGKLRQVSLRRNR 374
Cdd:PLN00113 418 gelpseftKLPLVYFLDISNNNLQG-RINSRKWDMPS--------LQMLSLARNKFFGgLPD--SFGSKRLENLDLSRNQ 486

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 4758460   375 LR-ALPRAlFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
Cdd:PLN00113 487 FSgAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 69-421 7.81e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.50  E-value: 7.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460    69 SFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNL 148
Cdd:PLN00113 255 SLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRL 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   149 QELALNQNQLDF-LPASLFTNlENLKLLDLSGNNLT-HLPKGLLGAqAKLERLLLHSNrlvSLDSGLLNSLGA---LTEL 223
Cdd:PLN00113 335 QVLQLWSNKFSGeIPKNLGKH-NNLTVLDLSTNNLTgEIPEGLCSS-GNLFKLILFSN---SLEGEIPKSLGAcrsLRRV 409

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   224 QFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENP-LAELPGvLFGEmgglqelwlnrTQL 302
Cdd:PLN00113 410 RLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKfFGGLPD-SFGS-----------KRL 477

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   303 RTLpaaafrNLSRLRYLGvtlsprlsALPQGaFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRAL 382
Cdd:PLN00113 478 ENL------DLSRNQFSG--------AVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPAS 542

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 4758460   383 FRNLSSLESVQLDHNQLEtlpGDV---FGALPRLTEVLLGHN 421
Cdd:PLN00113 543 FSEMPVLSQLDLSQNQLS---GEIpknLGNVESLVQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
195-254 1.01e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.01e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460    195 KLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHL 254
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
76-134 5.20e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 5.20e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4758460     76 LQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNAL 134
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
100-280 9.46e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.25  E-value: 9.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   100 LKTLRLSRNKITHLPGALLDKmvlLEQLFLDHNALRGIDQNMFQKLVnlqELALNQNQLDFLPASLFTNLENLKLLDlsg 179
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLTALPETLPPGLKTLEAGE--- 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   180 NNLTHLPKGLlgaQAKLERLLLHSNRLVSLDSGLLNSlgaLTELQFHRNHIRSIApgafDRLP-NLSSLTLSRNHLAFLP 258
Cdd:PRK15370 335 NALTSLPASL---PPELQVLDVSKNQITVLPETLPPT---ITTLDVSRNALTNLP----ENLPaALQIMQASRNNLVRLP 404

                        170       180
                 ....*....|....*....|....*
gi 4758460   259 SAL--FLHSHNLTLLTLFE-NPLAE 280
Cdd:PRK15370 405 ESLphFRGEGPQPTRIIVEyNPFSE 429
LRR_8 pfam13855
Leucine rich repeat;
147-206 1.68e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.68e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460    147 NLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRL 206
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
100-306 1.89e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.48  E-value: 1.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   100 LKTLRLSRNKITHLPGALLDKMVLLEqlfLDHNALRGIDQNMFQKlvnLQELALNQNQLDFLPASLftnLENLKLLDLSG 179
Cdd:PRK15370 222 IKTLYANSNQLTSIPATLPDTIQEME---LSINRITELPERLPSA---LQSLDLFHNKISCLPENL---PEELRYLSVYD 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   180 NNLTHLPKGLlgaQAKLERLLLHSNRLVSLDSGLLNSLGALTElqfHRNHIRSIaPGAFDrlPNLSSLTLSRNHLAFLPS 259
Cdd:PRK15370 293 NSIRTLPAHL---PSGITHLNVQSNSLTALPETLPPGLKTLEA---GENALTSL-PASLP--PELQVLDVSKNQITVLPE 363

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 4758460   260 ALflhSHNLTLLTLFENPLAELPGVLfgeMGGLQELWLNRTQLRTLP 306
Cdd:PRK15370 364 TL---PPTITTLDVSRNALTNLPENL---PAALQIMQASRNNLVRLP 404
LRR_8 pfam13855
Leucine rich repeat;
124-182 2.97e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 2.97e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4758460    124 LEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNL 182
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
421-472 5.13e-09

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 52.05  E-value: 5.13e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 4758460     421 NSWRCDCGLGPFLGWLRQhLGLVGGEEPPRCAGPGAHAGlPLWALPGGDAEC 472
Cdd:smart00082   1 NPFICDCELRWLLRWLQA-NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-411 5.87e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 5.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460    81 ISDSHISAVAPGTFSDLIKLKTLRLSRNKIT-HLPGALLDKMVLLEQLFLDHNALRGIDQNMFqkLVNLQELALNQNQLD 159
Cdd:PLN00113  76 LSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   160 FLPASLFTNLENLKLLDLSGNNLT-HLPkGLLGAQAKLERLLLHSNRLV---------------------SLDSGLLNSL 217
Cdd:PLN00113 154 GEIPNDIGSFSSLKVLDLGGNVLVgKIP-NSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynNLSGEIPYEI 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   218 GALTELQ----FHRNHIRSIaPGAFDRLPNLSSLTLSRNHLAF-LPSALFlHSHNLTLLTLFENPLA-ELPGvLFGEMGG 291
Cdd:PLN00113 233 GGLTSLNhldlVYNNLTGPI-PSSLGNLKNLQYLFLYQNKLSGpIPPSIF-SLQKLISLDLSDNSLSgEIPE-LVIQLQN 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   292 LQELWLNRTQLRTLPAAAFRNLSRLRYLGVtLSPRLSAlpqGAFQGLGE---LQVLALHSNGLTA-LPDGLLRGlGKLRQ 367
Cdd:PLN00113 310 LEILHLFSNNFTGKIPVALTSLPRLQVLQL-WSNKFSG---EIPKNLGKhnnLTVLDLSTNNLTGeIPEGLCSS-GNLFK 384

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 4758460   368 VSLRRNRLRA-LPRALfRNLSSLESVQLDHNQLE-TLPGDvFGALP 411
Cdd:PLN00113 385 LILFSNSLEGeIPKSL-GACRSLRRVRLQDNSFSgELPSE-FTKLP 428
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
147-399 1.03e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 58.25  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   147 NLQELALNQNQLDFLPASLftnlENLKLLDLSGNNLTH---LPKGLLgaqakleRLLLHSNRLVSLDSglLNSlgALTEL 223
Cdd:PRK15387 223 HITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTSlpvLPPGLL-------ELSIFSNPLTHLPA--LPS--GLCKL 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   224 QFHRNHIRS--IAPgafdrlPNLSSLTLSRNHLAFLPS------ALFLHSHNLTL----------LTLFENPLAELPgVL 285
Cdd:PRK15387 288 WIFGNQLTSlpVLP------PGLQELSVSDNQLASLPAlpselcKLWAYNNQLTSlptlpsglqeLSVSDNQLASLP-TL 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   286 FGEmggLQELWLNRTQLRTLPAAAfrnlSRLRYLGVTlSPRLSALPQGAFQgLGELQVLALHSNGLTALPDGLLrglgkl 365
Cdd:PRK15387 361 PSE---LYKLWAYNNRLTSLPALP----SGLKELIVS-GNRLTSLPVLPSE-LKELMVSGNRLTSLPMLPSGLL------ 425

                        250       260       270
                 ....*....|....*....|....*....|....
gi 4758460   366 rQVSLRRNRLRALPRALFrNLSSLESVQLDHNQL 399
Cdd:PRK15387 426 -SLSVYRNQLTRLPESLI-HLSSETTVNLEGNPL 457
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 394-472 2.76e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 57.01  E-value: 2.76e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4758460     394 LDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAEC 472
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC 80
LRR_8 pfam13855
Leucine rich repeat;
340-399 4.51e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.51e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460    340 ELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQL 399
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
243-425 4.52e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.86  E-value: 4.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   243 NLSSLTLSRNHLAFLPSALflhSHNLTLLTLFENPLAELPGVLfgeMGGLQELWLNRTQLRTLPAA-----AFRNLSRLR 317
Cdd:PRK15370 179 NKTELRLKILGLTTIPACI---PEQITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSIPATlpdtiQEMELSINR 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   318 YlgVTLSPRLSAlpqgafqglgELQVLALHSNGLTALPDGLLRGLgklRQVSLRRNRLRALPRALfrnLSSLESVQLDHN 397
Cdd:PRK15370 253 I--TELPERLPS----------ALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTLPAHL---PSGITHLNVQSN 314

                        170       180
                 ....*....|....*....|....*....
gi 4758460   398 QLETLPgdvfGALPRLTEVLL-GHNSWRC 425
Cdd:PRK15370 315 SLTALP----ETLPPGLKTLEaGENALTS 339
LRR_8 pfam13855
Leucine rich repeat;
99-158 6.48e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 6.48e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460     99 KLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQL 158
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
364-421 6.54e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 6.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 4758460    364 KLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
220-278 9.79e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 9.79e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4758460    220 LTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPL 278
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
314-375 2.21e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.21e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4758460    314 SRLRYLGVTLSpRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRL 375
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 175-397 4.22e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 4.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  175 LDLSGNNLTHLPKglLGAQAKLERLLLHSNRLVSLDSglLNSLGALTELQFHRNHIRSIAPgaFDRLPNLSSLTLSRNHL 254
Cdd:cd21340   7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  255 AFLpsalflhsHNLTLLTlfenplaelpgvlfgemgGLQELWLNRTQLRtlpaaafrnlsrlryLGVTLS--PR-LSALp 331
Cdd:cd21340  81 SVV--------EGLENLT------------------NLEELHIENQRLP---------------PGEKLTfdPRsLAAL- 118

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4758460  332 qgafqgLGELQVLALHSNGLTALPDglLRGLGKLRQVSLRRNRLRALPR--ALFRNLSSLESVQLDHN 397
Cdd:cd21340 119 ------SNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
148-280 6.56e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.92  E-value: 6.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   148 LQELALNQNQLDFLPA----------------SLFTNLENLKLLDLSGNNLTHLPKgllgAQAKLERLLLHSNRLVS--- 208
Cdd:PRK15387 304 LQELSVSDNQLASLPAlpselcklwaynnqltSLPTLPSGLQELSVSDNQLASLPT----LPSELYKLWAYNNRLTSlpa 379

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   209 LDSGL---------LNSL----GALTELQFHRNHIRSIApgafdRLPN-LSSLTLSRNHLAFLPSALfLHSHNLTLLTLF 274
Cdd:PRK15387 380 LPSGLkelivsgnrLTSLpvlpSELKELMVSGNRLTSLP-----MLPSgLLSLSVYRNQLTRLPESL-IHLSSETTVNLE 453


                 ....*.
gi 4758460   275 ENPLAE 280
Cdd:PRK15387 454 GNPLSE 459
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 94-210 1.24e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 1.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   94 FSDLIKLKTLRLSRNKITHLPGalLDKMVLLEQLFLD------------------------------HNALRGIDQnmFQ 143
Cdd:cd21340  64 LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIEnqrlppgekltfdprslaalsnslrvlnisGNNIDSLEP--LA 139

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4758460  144 KLVNLQELALNQNQLDFLP--ASLFTNLENLKLLDLSGNNLTHLPKgllgaqaKLERLLLHSNRLVSLD 210
Cdd:cd21340 140 PLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKPK-------YRDKIILASKSLEVLD 201
PLN03150 PLN03150
hypothetical protein; Provisional
 127-206 2.56e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 2.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   127 LFLDHNALRGIDQNMFQKLVNLQELALNQNQLD-FLPASlFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNR 205
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPS-LGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501


                 .
gi 4758460   206 L 206
Cdd:PLN03150 502 L 502
LRR_8 pfam13855
Leucine rich repeat;
64-110 2.64e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 2.64e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 4758460     64 VLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKI 110
Cdd:pfam13855  15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 99-403 4.53e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 43.32  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460     99 KLKTLRLSRNKITHLPGAL----LDKMVL----LEQLFLDHNALRGIDQNMFQKLVNLQELAlnqnqldflPASLFTNLE 170
Cdd:PLN03210  590 KLRLLRWDKYPLRCMPSNFrpenLVKLQMqgskLEKLWDGVHSLTGLRNIDLRGSKNLKEIP---------DLSMATNLE 660

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460    171 NLKLLDLSgnNLTHLPKGLLGAQaKLERLLL-HSNRLVSLDSGL-LNSLGALTELQFHRnhIRSIApgafDRLPNLSSLT 248
Cdd:PLN03210  661 TLKLSDCS--SLVELPSSIQYLN-KLEDLDMsRCENLEILPTGInLKSLYRLNLSGCSR--LKSFP----DISTNISWLD 731

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460    249 LSRNHLAFLPSAlfLHSHNLTLLTLFENPlaelpgvlfgemggLQELWlNRTQLRT-LPAAAFRNLSRLrylgvTLS--P 325
Cdd:PLN03210  732 LDETAIEEFPSN--LRLENLDELILCEMK--------------SEKLW-ERVQPLTpLMTMLSPSLTRL-----FLSdiP 789

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460    326 RLSALPqGAFQGLGELQVLAL-HSNGLTALPDGLlrGLGKLRQVSLRR-NRLRALPralfrNLSS-LESVQLDHNQLETL 402
Cdd:PLN03210  790 SLVELP-SSIQNLHKLEHLEIeNCINLETLPTGI--NLESLESLDLSGcSRLRTFP-----DISTnISDLNLSRTGIEEV 861


                  .
gi 4758460    403 P 403
Cdd:PLN03210  862 P 862
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 163-400 5.64e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 5.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  163 ASLFTNLENLKLLDLSGNNLTHLPKGLLG----AQAKLERLLLHSNRLVSLDSGLLnslgaltelqfhrnhirsIAPGAF 238
Cdd:cd00116  16 TELLPKLLCLQVLRLEGNTLGEEAAKALAsalrPQPSLKELCLSLNETGRIPRGLQ------------------SLLQGL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  239 DRLPNLSSLTLSRNHLAFLPSALF---LHSHNLTLLTLFENPLAELPGVLFGEmgGLQE---------LWLNRTQLRTLP 306
Cdd:cd00116  78 TKGCGLQELDLSDNALGPDGCGVLeslLRSSSLQELKLNNNGLGDRGLRLLAK--GLKDlppaleklvLGRNRLEGASCE 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  307 AAA--FRNLSRLRYLGVTLSPRLSALPQGAFQGL---GELQVLALHSNGLTALPD----GLLRGLGKLRQVSLRRNRLR- 376
Cdd:cd00116 156 ALAkaLRANRDLKELNLANNGIGDAGIRALAEGLkanCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTd 235

                       250       260
                ....*....|....*....|....*...
gi 4758460  377 ----ALPRALFRNLSSLESVQLDHNQLE 400
Cdd:cd00116 236 agaaALASALLSPNISLLTLSLSCNDIT 263
LRR_8 pfam13855
Leucine rich repeat;
291-351 1.11e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4758460    291 GLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSpRLSALPQGAFQGLGELQVLALHSNGL 351
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
242-302 1.54e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4758460    242 PNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQL 302
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 76-230 2.17e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 2.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   76 LQRLMISDSHISAVAPGTFSDLIK---LKTLRLSRNKI-----THLPGALLDKMVLLEQLFLDHNALRGID----QNMFQ 143
Cdd:cd00116  83 LQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEGAScealAKALR 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460  144 KLVNLQELALNQNQL-DFLPASL---FTNLENLKLLDLSGNNLTHLPKGLLGA----QAKLERLLLHSNRLVS-----LD 210
Cdd:cd00116 163 ANRDLKELNLANNGIgDAGIRALaegLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTDagaaaLA 242

                       170       180
                ....*....|....*....|
gi 4758460  211 SGLLNSLGALTELQFHRNHI 230
Cdd:cd00116 243 SALLSPNISLLTLSLSCNDI 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 202-421 3.26e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 3.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   202 HSNRLVSLDSGLLNSLGALTELQFHrnhirsiapgafdrLPNLSSLTLSRNHLAF-LPSALFLHSHNLTLLTLFENPLA- 279
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISSAIFR--------------LPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTg 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460   280 ELPGvlfGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPqGAFQGLGELQVLALHSNGLTAlpdGLL 359
Cdd:PLN00113 133 SIPR---GSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIP-NSLTNLTSLEFLTLASNQLVG---QIP 205

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4758460   360 RGLGKLRQ---VSLRRNRLRA-LPRALFRnLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
Cdd:PLN00113 206 RELGQMKSlkwIYLGYNNLSGeIPYEIGG-LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270
LRR_9 pfam14580
Leucine-rich repeat;
166-282 3.88e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.59  E-value: 3.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758460    166 FTNLENLKLLDLSGNNLTHLPKglLGAQA-KLERLLLHSNRLVSLDS-GLLNSLGALTelqFHRNHIRSIAPGAFDRLPN 243
Cdd:pfam14580  15 YTNPVRERELDLRGYKIPIIEN--LGATLdQFDTIDFSDNEIRKLDGfPLLRRLKTLL---LNNNRICRIGEGLGEALPN 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 4758460    244 LSSLTLSRNHLAFLPSALFLHS-HNLTLLTLFENPLAELP 282
Cdd:pfam14580  90 LTELILTNNNLQELGDLDPLASlKKLTFLSLLRNPVTNKP 129
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 147-182 4.53e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 4.53e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 4758460    147 NLQELALNQNQLDFLPasLFTNLENLKLLDLSGNNL 182
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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