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Conserved domains on  [gi|4757944|ref|NP_004347|]
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CD81 antigen isoform 1 [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 11992908)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0016020
PubMed:  15763890|11756464|19709882|16024509|32974937
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
10-228 8.63e-40

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 135.14  E-value: 8.63e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757944     10 IKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTNLLYLelgdkpapNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQC 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLS--------EASAYIPILLIVLGAVIFLVGFLGCCGALKENRC 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757944     90 LLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVVD--DDANNAKAVVKTFHETLDCCGSstltaltt 167
Cdd:pfam00335  73 LLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDwlDLYSCLNSALDSLQSEFGCCGG-------- 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4757944    168 svlknnlcpsgsniisnlfkedCHQKIDDLFSGKLYLIGIAAIVVAVIMIFEMILSMVLCC 228
Cdd:pfam00335 145 ----------------------CKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
10-228 8.63e-40

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 135.14  E-value: 8.63e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757944     10 IKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTNLLYLelgdkpapNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQC 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLS--------EASAYIPILLIVLGAVIFLVGFLGCCGALKENRC 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757944     90 LLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVVD--DDANNAKAVVKTFHETLDCCGSstltaltt 167
Cdd:pfam00335  73 LLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDwlDLYSCLNSALDSLQSEFGCCGG-------- 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4757944    168 svlknnlcpsgsniisnlfkedCHQKIDDLFSGKLYLIGIAAIVVAVIMIFEMILSMVLCC 228
Cdd:pfam00335 145 ----------------------CKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
CD81_like_LEL cd03151
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. ...
 113-202 2.30e-34

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD81, also referred to as Target for anti-proliferative antigen-1, TAPA-1, is found in virtually all tissues, may be involved in regulation of cell growth and has been described as a member of the CD19/CD21/Leu-13 signal transduction complex identified on B cells (the B-Cell co-receptor).


Pssm-ID: 239404  Cd Length: 84  Bit Score: 118.29  E-value: 2.30e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757944  113 FVNKDQIAKDVKQFYDQALQQAVvDDDANNAKAVVKTFHETLDCCGSSTLTALtTSVLKNNLCPSGsniiSNLFKEDCHQ 192
Cdd:cd03151   1 FINKDQIIKEVQNFYDSAYQDAV-TDTRSKGTAVLKTFHSTLDCCGKGNLTAL-LSLLSTDLCPKK----LLLDTKDCHQ 74

                        90
                ....*....|
gi 4757944  193 KIDDLFSGKL 202
Cdd:cd03151  75 EIDDLFSEKL 84
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
10-228 8.63e-40

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 135.14  E-value: 8.63e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757944     10 IKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTNLLYLelgdkpapNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQC 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLS--------EASAYIPILLIVLGAVIFLVGFLGCCGALKENRC 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757944     90 LLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVVD--DDANNAKAVVKTFHETLDCCGSstltaltt 167
Cdd:pfam00335  73 LLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDwlDLYSCLNSALDSLQSEFGCCGG-------- 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4757944    168 svlknnlcpsgsniisnlfkedCHQKIDDLFSGKLYLIGIAAIVVAVIMIFEMILSMVLCC 228
Cdd:pfam00335 145 ----------------------CKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
CD81_like_LEL cd03151
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. ...
 113-202 2.30e-34

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD81, also referred to as Target for anti-proliferative antigen-1, TAPA-1, is found in virtually all tissues, may be involved in regulation of cell growth and has been described as a member of the CD19/CD21/Leu-13 signal transduction complex identified on B cells (the B-Cell co-receptor).


Pssm-ID: 239404  Cd Length: 84  Bit Score: 118.29  E-value: 2.30e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757944  113 FVNKDQIAKDVKQFYDQALQQAVvDDDANNAKAVVKTFHETLDCCGSSTLTALtTSVLKNNLCPSGsniiSNLFKEDCHQ 192
Cdd:cd03151   1 FINKDQIIKEVQNFYDSAYQDAV-TDTRSKGTAVLKTFHSTLDCCGKGNLTAL-LSLLSTDLCPKK----LLLDTKDCHQ 74

                        90
                ....*....|
gi 4757944  193 KIDDLFSGKL 202
Cdd:cd03151  75 EIDDLFSEKL 84
CD9_LEL cd03152
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins ...
 113-202 1.40e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD9 is found in virtually all tissues and is potentially involved in developmental processes. It associates with the tetraspanins CD81 and CD63, as well as with some integrin, and has been shown to be involved in a variety of activation, adhesion, and cell motility functions, as well as cell-cell interactions - such as during fertilization.


Pssm-ID: 239405  Cd Length: 84  Bit Score: 53.16  E-value: 1.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757944  113 FVNKDQIAKDVKQFYDQALQQAVVDDDaNNAKAVVKTFHETLDCCGSSTLTALTTSVlknnLCPSGsNIISNLFKEDCHQ 192
Cdd:cd03152   1 FSNKDKVVKEVQTFYRQTYAKYKQSRD-PPLKETLKAIHFALDCCGPTGGLEQFVTD----TCPKK-EGLENLITKSCPD 74

                        90
                ....*....|
gi 4757944  193 KIDDLFSGKL 202
Cdd:cd03152  75 AIDDVFNSKL 84
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 113-202 1.29e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 50.97  E-value: 1.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757944  113 FVNKDQIAKDVKQFYDQALQQAVVDDDANNAkavVKTFHETLDCCGSSTLTALTTSVLK-NNLCPSGSNII--SNLFKED 189
Cdd:cd03127   1 FVYRDQLESLVSDTLNDAWDEYYVDDDFQEA---MDALQSTFECCGVNGPTDYLDLRLLvPSSCCKGTDGNcgLNLYTEG 77

                        90
                ....*....|...
gi 4757944  190 CHQKIDDLFSGKL 202
Cdd:cd03127  78 CLEKLVDFLRSNL 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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