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Conserved domains on  [gi|4502477|ref|NP_003930|]
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F-box/WD repeat-containing protein 1A isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 267-545 5.23e-82

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 258.42  E-value: 5.23e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  267 SKGVYCLQYDD--QKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNT 342
Cdd:cd00200   9 TGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  343 LIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPtdiTLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 418
Cdd:cd00200  89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETG---KCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  419 TCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 494
Cdd:cd00200 166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4502477  495 WDLVAAldprapagtLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 545
Cdd:cd00200 246 WDLRTG---------ECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289
F-box_FBXW1A cd22182
F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; ...
 139-198 3.10e-32

F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438953  Cd Length: 60  Bit Score: 118.24  E-value: 3.10e-32
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  139 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 198
Cdd:cd22182   1 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 60
Beta-TrCP_D pfam12125
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 103-141 3.91e-25

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with pfam00646, pfam00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerization of the protein. dimerization is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


:

Pssm-ID: 463465  Cd Length: 39  Bit Score: 97.83  E-value: 3.91e-25
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4502477    103 KYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 141
Cdd:pfam12125   1 KYFDKWNESDQVDFVEHLLSRMCHYQHGHINSYLKPMLQ 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 267-545 5.23e-82

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 258.42  E-value: 5.23e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  267 SKGVYCLQYDD--QKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNT 342
Cdd:cd00200   9 TGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  343 LIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPtdiTLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 418
Cdd:cd00200  89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETG---KCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  419 TCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 494
Cdd:cd00200 166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4502477  495 WDLVAAldprapagtLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 545
Cdd:cd00200 246 WDLRTG---------ECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
258-545 1.25e-79

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 255.99  E-value: 1.25e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  258 QRIHCRSETSKGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 333
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  334 VNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGD 409
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGK---LLRTLTGHSGSVRSVAFspDGRLLASGSAD 267

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  410 RTIKVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVS 485
Cdd:COG2319 268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502477  486 GAYDGKIKVWDLvaaldprapAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 545
Cdd:COG2319 348 GSDDGTVRLWDL---------ATGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRLWD 400
F-box_FBXW1A cd22182
F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; ...
 139-198 3.10e-32

F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438953  Cd Length: 60  Bit Score: 118.24  E-value: 3.10e-32
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  139 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 198
Cdd:cd22182   1 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 60
Beta-TrCP_D pfam12125
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 103-141 3.91e-25

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with pfam00646, pfam00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerization of the protein. dimerization is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 463465  Cd Length: 39  Bit Score: 97.83  E-value: 3.91e-25
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4502477    103 KYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 141
Cdd:pfam12125   1 KYFDKWNESDQVDFVEHLLSRMCHYQHGHINSYLKPMLQ 39
Beta-TrCP_D smart01028
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 102-141 6.16e-23

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with F-box domain, WD domain. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein. Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 198096  Cd Length: 40  Bit Score: 91.40  E-value: 6.16e-23
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4502477     102 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 141
Cdd:smart01028   1 VKYFEKWSESDQVDFVEHLISRMCHYQHGHINSYLKPMLQ 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 403-557 1.97e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 67.03  E-value: 1.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477   403 IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD---RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVrCIRFD 479
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC-CVQFP 626

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477   480 N---KRIVSGAYDGKIKVWDLvaaldpRAPAGTLClrTLVEHSGRVFRLQF-DEFQIVSSSHDDTILIWDFLNDPAAQAE 555
Cdd:PLN00181 627 SesgRSLAFGSADHKVYYYDL------RNPKLPLC--TMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWDLSMSISGINE 698


                 ..
gi 4502477   556 PP 557
Cdd:PLN00181 699 TP 700
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 145-192 6.68e-10

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 54.41  E-value: 6.68e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 4502477    145 ITALParglDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:pfam12937   1 LSSLP----DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 296-333 5.66e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 5.66e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4502477     296 TLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 333
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
460-496 2.92e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 2.92e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4502477    460 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 496
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
FBOX smart00256
A Receptor for Ubiquitination Targets;
154-192 4.29e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 46.28  E-value: 4.29e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4502477     154 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 267-545 5.23e-82

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 258.42  E-value: 5.23e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  267 SKGVYCLQYDD--QKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNT 342
Cdd:cd00200   9 TGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  343 LIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPtdiTLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 418
Cdd:cd00200  89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETG---KCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  419 TCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 494
Cdd:cd00200 166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4502477  495 WDLVAAldprapagtLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 545
Cdd:cd00200 246 WDLRTG---------ECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
258-545 1.25e-79

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 255.99  E-value: 1.25e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  258 QRIHCRSETSKGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 333
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  334 VNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGD 409
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGK---LLRTLTGHSGSVRSVAFspDGRLLASGSAD 267

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  410 RTIKVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVS 485
Cdd:COG2319 268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502477  486 GAYDGKIKVWDLvaaldprapAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 545
Cdd:COG2319 348 GSDDGTVRLWDL---------ATGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
267-497 2.12e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 229.41  E-value: 2.12e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  267 SKGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNT 342
Cdd:COG2319 162 SGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGKLLRT 241

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  343 LIHHCEAVLHLRFN-NG-MMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 418
Cdd:COG2319 242 LTGHSGSVRSVAFSpDGrLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLA 318

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  419 TCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKV 494
Cdd:COG2319 319 TGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRL 398


                ...
gi 4502477  495 WDL 497
Cdd:COG2319 399 WDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
276-545 1.11e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.82  E-value: 1.11e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHL 353
Cdd:COG2319   5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAAspDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  354 RF--NNGMMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGH 429
Cdd:COG2319  85 AFspDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  430 KRGIACLQY-RD-RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLvaaldpra 505
Cdd:COG2319 162 SGAVTSVAFsPDgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDL-------- 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4502477  506 pAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 545
Cdd:COG2319 234 -ATGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 299-546 1.65e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 183.69  E-value: 1.65e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  299 CKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLntlihhceavlhlrfnngmmvtcskdrsiavwdmas 376
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFspDGKLLATGSGDGTIKVWDLETGELL------------------------------------ 44

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  377 ptditlrRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTI 452
Cdd:cd00200  45 -------RTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSpdGRILSSSSRDKTI 117

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  453 RLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAALdprapagtlCLRTLVEHSGRVFRLQF--D 528
Cdd:cd00200 118 KVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGK---------CVATLTGHTGEVNSVAFspD 188

                       250
                ....*....|....*...
gi 4502477  529 EFQIVSSSHDDTILIWDF 546
Cdd:cd00200 189 GEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
267-458 4.83e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.19  E-value: 4.83e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  267 SKGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNT 342
Cdd:COG2319 204 TGAVRSVAFspDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRT 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  343 LIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 418
Cdd:COG2319 284 LTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGK---LLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLA 360

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 4502477  419 TCEFVRTLNGHKRGIACLQY-RD-RLVVSGSSDNTIRLWDIE 458
Cdd:COG2319 361 TGELLRTLTGHTGAVTSVAFsPDgRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
258-419 1.72e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.91  E-value: 1.72e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  258 QRIHCRSETSKGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 333
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWD 316

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  334 VNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGD 409
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGE---LLRTLTGHTGAVTSVAFspDGRTLASGSAD 393

                       170
                ....*....|
gi 4502477  410 RTIKVWNTST 419
Cdd:COG2319 394 GTVRLWDLAT 403
F-box_FBXW1A cd22182
F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; ...
 139-198 3.10e-32

F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438953  Cd Length: 60  Bit Score: 118.24  E-value: 3.10e-32
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  139 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 198
Cdd:cd22182   1 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 60
F-box_FBXW1 cd22130
F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; ...
 141-191 4.38e-31

F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438902  Cd Length: 51  Bit Score: 114.49  E-value: 4.38e-31
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 4502477  141 QRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKK 191
Cdd:cd22130   1 QRDFISALPAKGLDHIAENILSYLDAKSLCAAELVCKEWYRVIADGMLWKK 51
F-box_FBXW1B cd22183
F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; ...
 141-191 1.42e-30

F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438954  Cd Length: 51  Bit Score: 113.08  E-value: 1.42e-30
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 4502477  141 QRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKK 191
Cdd:cd22183   1 QRDFITALPAKGLDHIAENILSYLDAESLCAAELVCKEWQRVISEGMLWKK 51
Beta-TrCP_D pfam12125
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 103-141 3.91e-25

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with pfam00646, pfam00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerization of the protein. dimerization is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 463465  Cd Length: 39  Bit Score: 97.83  E-value: 3.91e-25
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4502477    103 KYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 141
Cdd:pfam12125   1 KYFDKWNESDQVDFVEHLLSRMCHYQHGHINSYLKPMLQ 39
Beta-TrCP_D smart01028
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 102-141 6.16e-23

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with F-box domain, WD domain. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein. Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 198096  Cd Length: 40  Bit Score: 91.40  E-value: 6.16e-23
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4502477     102 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 141
Cdd:smart01028   1 VKYFEKWSESDQVDFVEHLISRMCHYQHGHINSYLKPMLQ 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 403-557 1.97e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 67.03  E-value: 1.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477   403 IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD---RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVrCIRFD 479
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC-CVQFP 626

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477   480 N---KRIVSGAYDGKIKVWDLvaaldpRAPAGTLClrTLVEHSGRVFRLQF-DEFQIVSSSHDDTILIWDFLNDPAAQAE 555
Cdd:PLN00181 627 SesgRSLAFGSADHKVYYYDL------RNPKLPLC--TMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWDLSMSISGINE 698


                 ..
gi 4502477   556 PP 557
Cdd:PLN00181 699 TP 700
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 144-193 5.91e-11

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 57.71  E-value: 5.91e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 4502477  144 FITALPARgldhIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLI 193
Cdd:cd22147   1 FLSALPVE----LSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 145-192 6.68e-10

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 54.41  E-value: 6.68e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 4502477    145 ITALParglDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:pfam12937   1 LSSLP----DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 159-192 5.82e-09

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 51.84  E-value: 5.82e-09
                        10        20        30
                ....*....|....*....|....*....|....
gi 4502477  159 NILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:cd22132  11 HIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKEL 44
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 296-333 5.66e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 5.66e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4502477     296 TLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 333
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 460-496 1.68e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.68e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4502477     460 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 496
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
460-496 2.92e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 2.92e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4502477    460 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 496
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 131-190 3.98e-07

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 47.03  E-value: 3.98e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  131 HINSYLKPMLQRDFITALPARgldhIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWK 190
Cdd:cd22133   4 HMMQVIEPQFQRDFISLLPKE----LALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59
WD40 pfam00400
WD domain, G-beta repeat;
298-333 4.20e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 4.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4502477    298 ECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 333
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
FBOX smart00256
A Receptor for Ubiquitination Targets;
154-192 4.29e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 46.28  E-value: 4.29e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4502477     154 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
 144-190 1.74e-06

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 44.97  E-value: 1.74e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 4502477  144 FITALParglDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWK 190
Cdd:cd22148   1 FISLLP----EHLALKILSYLSPKELLIASQVSKTWRRLASSNELWK 43
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 154-184 2.04e-06

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 44.36  E-value: 2.04e-06
                        10        20        30
                ....*....|....*....|....*....|.
gi 4502477  154 DHIAENILSYLDAKSLCAAELVCKEWYRVTS 184
Cdd:cd09917   5 DEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 160-192 2.20e-06

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 44.54  E-value: 2.20e-06
                        10        20        30
                ....*....|....*....|....*....|...
gi 4502477  160 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:cd22117  12 ILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKEL 44
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
 145-192 2.79e-06

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 44.23  E-value: 2.79e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 4502477  145 ITALPARgldhIAENILSYLDAKSLCAAELVCKEWYRVTSD-GMLWKKL 192
Cdd:cd22113   1 IELLPPE----MSLRIFSQLDVQSLCRASQTCKTWNDLIENsDYLWRPH 45
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
 147-192 2.94e-06

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 44.24  E-value: 2.94e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 4502477  147 ALPARGLDHIaenILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:cd22109   4 SLRRRDALFC---VFSYLDTKSLLRCAEVCREWRDVSRHPALWQRV 46
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 419-456 4.71e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.71e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4502477     419 TCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWD 456
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 381-416 5.79e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 5.79e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4502477     381 TLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWN 416
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 355-529 6.02e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.12  E-value: 6.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477   355 FNNGMMVTCSKDRSIAVWDMasPTDITLRRV------LVGHRAAVNVVDFD---DKYIVSASGDRTIKVWNTSTCEFVRT 425
Cdd:PTZ00421  86 FDPQKLFTASEDGTIMGWGI--PEEGLTQNIsdpivhLQGHTKKVGIVSFHpsaMNVLASAGADMVVNVWDVERGKAVEV 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477   426 LNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHE--ELVRCIRFDNKRIV-----SGAYDGKIKVWD 496
Cdd:PTZ00421 164 IKCHSDQITSLEWnlDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAsaKSQRCLWAKRKDLIitlgcSKSQQRQIMLWD 243

                        170       180       190
                 ....*....|....*....|....*....|...
gi 4502477   497 lvaALDPRAPAGTlclrTLVEHSGRVFRLQFDE 529
Cdd:PTZ00421 244 ---TRKMASPYST----VDLDQSSALFIPFFDE 269
WD40 pfam00400
WD domain, G-beta repeat;
421-456 8.05e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 8.05e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4502477    421 EFVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWD 456
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
 154-192 8.63e-06

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 42.79  E-value: 8.63e-06
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 4502477  154 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:cd22091   6 DEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKRL 44
PTZ00421 PTZ00421
coronin; Provisional
 275-373 9.21e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.35  E-value: 9.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477   275 YDDQKIVSGLRDNTIKIWD-------KNTLECKRILTGHTGSVLCLQYD---ERVIITGSSDSTVRVWDVNTGEMLNTLI 344
Cdd:PTZ00421  86 FDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHpsaMNVLASAGADMVVNVWDVERGKAVEVIK 165

                         90       100       110
                 ....*....|....*....|....*....|.
gi 4502477   345 HHCEAVLHLRFN--NGMMVTCSKDRSIAVWD 373
Cdd:PTZ00421 166 CHSDQITSLEWNldGSLLCTTSKDKKLNIID 196
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
366-505 1.30e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.61  E-value: 1.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  366 DRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYI-VSASGDRTIKVWNTSTCEFVRTLN--GHKRGIACLQYRDRL 442
Cdd:COG3391  45 VGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGKVVATIPvgGGPRGLAVDPDGGRL 124

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4502477  443 VVSGSSDNTIRLWDIECGACLRVLEGHEElVRCIRF--DNKRI-VSGAYDGKIKVwdLVAALDPRA 505
Cdd:COG3391 125 YVADSGNGRVSVIDTATGKVVATIPVGAG-PHGIAVdpDGKRLyVANSGSNTVSV--IVSVIDTAT 187
WD40 pfam00400
WD domain, G-beta repeat;
381-416 1.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4502477    381 TLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWN 416
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_ECT2L cd22173
F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and ...
 143-212 2.15e-05

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438944  Cd Length: 52  Bit Score: 42.01  E-value: 2.15e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  143 DFITALPArgldHIAENILSYLDAKSLCAAELVCkeWYrvtsdgmlWKKLIERmvrtDSLWRGLAERRGW 212
Cdd:cd22173   1 DFTTVLPR----FLSLYIFSFLDPRSLCRAAQVS--WH--------WKFLAEQ----DCLWMPKCVKFGW 52
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
 160-192 3.05e-05

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 41.47  E-value: 3.05e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 4502477  160 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:cd22093  12 ILSYLDASSLLCISCVNKLFYQLANDNALWRKL 44
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 309-461 3.92e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 3.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477   309 SVLCLQ-YDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG---MMVTCSKDRSIAVWDMASPTDITLrr 384
Cdd:PLN00181 536 SGICWNsYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSAdptLLASGSDDGSVKLWSINQGVSIGT-- 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477   385 vlVGHRAAVNVVDFDD---KYIVSASGDRTIKVWNTSTCEF-VRTLNGHKRGIACLQYRDR-LVVSGSSDNTIRLWDIEC 459
Cdd:PLN00181 614 --IKTKANICCVQFPSesgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSsTLVSSSTDNTLKLWDLSM 691


                 ..
gi 4502477   460 GA 461
Cdd:PLN00181 692 SI 693
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 143-184 5.88e-05

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 40.39  E-value: 5.88e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 4502477  143 DFITALPARgldhIAENILSYLDAKSLCAAELVCKEWYRVTS 184
Cdd:cd22131   1 DFLKLLPLE----LSFYLLSFLDPESLLTCCLVSKQWNKVIS 38
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 160-192 7.33e-05

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 40.30  E-value: 7.33e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 4502477  160 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:cd22139  12 IFSFLSPKDLCQVALVCRRFNRLASDESLWKQI 44
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 154-185 8.09e-05

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 40.14  E-value: 8.09e-05
                        10        20        30
                ....*....|....*....|....*....|..
gi 4502477  154 DHIAENILSYLDAKSLCAAELVCKEWYRVTSD 185
Cdd:cd22157   5 DDLVEEILSRLPAKSLLRFRCVCKQWNSLISS 36
F-box_FBXO9 cd22089
F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called ...
 144-195 1.03e-04

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438861  Cd Length: 53  Bit Score: 40.29  E-value: 1.03e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 4502477  144 FITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIER 195
Cdd:cd22089   2 HISALPSEILLYILRWVVSDLDLRSLEQLSLVCRKFYLLARDPSIWRLACER 53
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 154-191 1.15e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 39.83  E-value: 1.15e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4502477    154 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKK 191
Cdd:pfam00646   6 DDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
F-box_FBXO16-like cd22094
F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 ...
 143-190 1.49e-04

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438866  Cd Length: 49  Bit Score: 39.74  E-value: 1.49e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 4502477  143 DFITALPARgldhIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWK 190
Cdd:cd22094   1 DFTRVLPRF----LSLYIFSYLDPRSLCRAAQVSWYWKFLCESDELWL 44
F-box_FBXO16 cd22172
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ...
 160-212 2.09e-04

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438943  Cd Length: 55  Bit Score: 39.19  E-value: 2.09e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 4502477  160 ILSYLDAKSLCAAELVCkeWYrvtsdgmlWKKLIErmvrTDSLWRGLAERRGW 212
Cdd:cd22172  17 IFSFLDPRSLCRCAQVC--WY--------WKYLTE----LDQLWMPKCLRFGW 55
F-box_FBXO45 cd22111
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ...
 146-184 2.10e-04

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438883  Cd Length: 36  Bit Score: 38.80  E-value: 2.10e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 4502477  146 TALPARGLdhiaENILSYLDAKSLCAAELVCKEWYRVTS 184
Cdd:cd22111   2 ARLPSRVL----EVIFSYLDLPDLRNCSLVCKSWYRLLN 36
F-box_FBXO7 cd22087
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ...
 159-192 2.51e-04

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438859  Cd Length: 45  Bit Score: 38.82  E-value: 2.51e-04
                        10        20        30
                ....*....|....*....|....*....|....
gi 4502477  159 NILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:cd22087  11 RILSLLDVRSLLSLSQVCRDLNSATNDQLLWRFL 44
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 511-545 3.13e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.13e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 4502477     511 CLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 545
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 336-373 3.19e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4502477     336 TGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWD 373
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 154-189 3.37e-04

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 38.46  E-value: 3.37e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 4502477  154 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLW 189
Cdd:cd22151   5 DDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLW 40
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
 160-192 3.43e-04

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 38.51  E-value: 3.43e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 4502477  160 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:cd22137  11 IFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNL 43
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 159-189 3.68e-04

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 38.09  E-value: 3.68e-04
                        10        20        30
                ....*....|....*....|....*....|.
gi 4502477  159 NILSYLDAKSLCAAELVCKEWYRVTSDGMLW 189
Cdd:cd22118  11 KIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
F-box_EMI cd22086
F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI ...
 151-182 8.61e-04

F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI family includes FBX5 (EMI1) and FBX43 (EMI2), which are anaphase-promoting complex/cyclosome (APC/C) inhibitors that bind APC/C-CCD20 (Cell division cycle protein 20) and/or APC/C-CDH1 (CDC20 homologue 1) complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438858  Cd Length: 48  Bit Score: 37.48  E-value: 8.61e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 4502477  151 RGLDHIAENILSYLDAKSLCAAELVCKEWYRV 182
Cdd:cd22086   6 RNCPHILSKILSYLSPEDLCRVSCVSKTWRQI 37
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 154-185 1.25e-03

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 36.55  E-value: 1.25e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 4502477  154 DHIAENILSYLD-AKSLCAAELVCKEWYRVTSD 185
Cdd:cd22110   6 EEILEYILSYLSpYGDLKSAALVCKRWHRIIKG 38
WD40 pfam00400
WD domain, G-beta repeat;
511-545 1.72e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 4502477    511 CLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 545
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_FBXL7 cd22120
F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also ...
 154-192 2.45e-03

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438892  Cd Length: 44  Bit Score: 35.82  E-value: 2.45e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 4502477  154 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:cd22120   6 DDVILQIFSHLPTNQLCRCARVCRRWYNLAWDPRLWTTI 44
PTZ00420 PTZ00420
coronin; Provisional
 346-416 2.49e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477   346 HCEAVLHLRFN---NGMMVTCSKDRSIAVWDMASpTDITLRRV------LVGHRAAVNVVDFD--DKYIVSASG-DRTIK 413
Cdd:PTZ00420  73 HTSSILDLQFNpcfSEILASGSEDLTIRVWEIPH-NDESVKEIkdpqciLKGHKKKISIIDWNpmNYYIMCSSGfDSFVN 151


                 ...
gi 4502477   414 VWN 416
Cdd:PTZ00420 152 IWD 154
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 160-190 2.86e-03

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 35.79  E-value: 2.86e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 4502477  160 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWK 190
Cdd:cd22123  12 ILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
275-419 3.79e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.29  E-value: 3.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  275 YDDQKI-VSGLRDNTIKIWDKNTLE-CKRILTGHTGSVLCLQYD-ERVIITGSSDSTVRVWDVNTGEMLNTlIHHCEAVL 351
Cdd:COG3391  77 ADGRRLyVANSGSGRVSVIDLATGKvVATIPVGGGPRGLAVDPDgGRLYVADSGNGRVSVIDTATGKVVAT-IPVGAGPH 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502477  352 HLRF---NNGMMVTCSKDRSIA----VWDMASPTdiTLRRVLVGHRaAVNV-VDFDDKYIV--------SASGDRTIKVW 415
Cdd:COG3391 156 GIAVdpdGKRLYVANSGSNTVSvivsVIDTATGK--VVATIPVGGG-PVGVaVSPDGRRLYvanrgsntSNGGSNTVSVI 232


                ....
gi 4502477  416 NTST 419
Cdd:COG3391 233 DLAT 236
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 145-192 4.77e-03

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 35.33  E-value: 4.77e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 4502477  145 ITALParglDHIAENILSYLDAKSLC-AAELVCKEWYRVTSDGM--LWKKL 192
Cdd:cd22095   2 IQQLP----EELLRNIFAFLPAEDLYqNISLVCRHWRDIVSDPLfiPWKKL 48
WD40 pfam00400
WD domain, G-beta repeat;
337-373 5.36e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 5.36e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4502477    337 GEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWD 373
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_FBXL2-like cd22115
F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) ...
 160-190 8.25e-03

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438887  Cd Length: 45  Bit Score: 34.70  E-value: 8.25e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 4502477  160 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWK 190
Cdd:cd22115  15 IFSFLDVVTLCRCAQVSKYWNVLALDGSNWQ 45
F-box_FBXO8 cd22088
F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called ...
 156-192 8.32e-03

F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called FBX8, or F-box/SEC7 protein FBS, is a novel component of F-box proteins which contains an F-box domain and a putative Sec7 domain. FBX8 was originally identified as a Skp1-binding protein. It is involved in the ubiquitin-dependent proteolytic pathway. It acts as a metastasis suppressor that functions through mTOR signaling pathway. FBXO8 may promote the activation of ADP-ribosylation factor (ARF) through replacement of GDP with GTP. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438860  Cd Length: 46  Bit Score: 34.61  E-value: 8.32e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 4502477  156 IAENILSYLDAKSLCAAELVckeWYRVTSDGMLWKKL 192
Cdd:cd22088  11 LSLTVLSHLNATDLCLASCV---WQDLANDELLWQGL 44
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 159-192 9.00e-03

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 34.54  E-value: 9.00e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 4502477  159 NILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 192
Cdd:cd22084  11 NILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRL 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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