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Conserved domains on  [gi|109452591|ref|NP_003840|]
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succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial precursor [Homo sapiens]

Protein Classification

succinate--CoA ligase [ADP/GDP-forming] subunit alpha( domain architecture ID 11488210)

succinate--CoA ligase [ADP/GDP-forming] subunit alpha binds the substrates coenzyme A and phosphate as part of the heterodimeric enzyme succinyl-CoA synthetase that functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 19-344 4.73e-174

succinyl-CoA synthetase alpha subunit; Provisional


:

Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 485.76  E-value: 4.73e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  19 SGLAAARLLSRSFLLpqngirhcSYTASRQHLYVDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQTHL-- 96
Cdd:PTZ00187   1 LKGAAFMILKVSFRA--------RSSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkh 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  97 GLPVFNTVKEAKEQTGATASVIYVPPPFAAAAINEAIEAEIPLVVCITEGIPQQDMVRVKHKLLRQEKTRLIGPNCPGVI 176
Cdd:PTZ00187  73 GLPVFATVKEAKKATGADASVIYVPPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGII 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 177 NPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDSATEGIILIG 256
Cdd:PTZ00187 153 KPGECKIGIMPGHIHKKGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIG 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 257 EIGGNAEENAAEFLKQHnsgPNSKPVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTI 336
Cdd:PTZ00187 233 EIGGTAEEEAAEWIKNN---PIKKPVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTM 309


                 ....*...
gi 109452591 337 YKEFEKRK 344
Cdd:PTZ00187 310 LEVMKKKG 317
 
Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 19-344 4.73e-174

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 485.76  E-value: 4.73e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  19 SGLAAARLLSRSFLLpqngirhcSYTASRQHLYVDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQTHL-- 96
Cdd:PTZ00187   1 LKGAAFMILKVSFRA--------RSSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkh 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  97 GLPVFNTVKEAKEQTGATASVIYVPPPFAAAAINEAIEAEIPLVVCITEGIPQQDMVRVKHKLLRQEKTRLIGPNCPGVI 176
Cdd:PTZ00187  73 GLPVFATVKEAKKATGADASVIYVPPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGII 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 177 NPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDSATEGIILIG 256
Cdd:PTZ00187 153 KPGECKIGIMPGHIHKKGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIG 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 257 EIGGNAEENAAEFLKQHnsgPNSKPVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTI 336
Cdd:PTZ00187 233 EIGGTAEEEAAEWIKNN---PIKKPVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTM 309


                 ....*...
gi 109452591 337 YKEFEKRK 344
Cdd:PTZ00187 310 LEVMKKKG 317
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 51-338 2.53e-156

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 439.50  E-value: 2.53e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  51 YVDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAAIN 130
Cdd:COG0074    3 LVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADAIL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 131 EAIEAEIPLVVCITEGIPQQDMVRVKHKLlRQEKTRLIGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAV 210
Cdd:COG0074   83 EAIDAGIKLIVCITEGIPVLDMVRVKRYA-KAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 211 HQTTQVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDSATEGIILIGEIGGNAEENAAEFLKQHnsgpNSKPVVSFIAGLT 290
Cdd:COG0074  162 WQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKEN----MTKPVVAYIAGRT 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 109452591 291 APPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTIYK 338
Cdd:COG0074  238 APPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKK 285
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 52-336 1.12e-144

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 410.27  E-value: 1.12e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591   52 VDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAAINE 131
Cdd:TIGR01019   3 LDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAIFE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  132 AIEAEIPLVVCITEGIPQQDMVRVKHKLLRQeKTRLIGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVH 211
Cdd:TIGR01019  83 AIDAGIELIVCITEGIPVHDMLKVKRYMEES-GTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAVH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  212 QTTQVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDSATEGIILIGEIGGNAEENAAEFLKQHnsgpNSKPVVSFIAGLTA 291
Cdd:TIGR01019 162 QLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQN----MSKPVVGFIAGATA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 109452591  292 PPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTI 336
Cdd:TIGR01019 238 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELL 282
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 53-146 7.86e-29

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 106.91  E-value: 7.86e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591   53 DKNTKIICQGFTGK--QGT-FHSQQALEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAAI 129
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiQGLnYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 109452591  130 NEAIEAEIPLVVCITEG 146
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 52-147 1.40e-24

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 95.65  E-value: 1.40e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591    52 VDKNTKIICQGFTGKQGTFHSQQA---LEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAA 128
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMrnlLEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 109452591   129 INEAIEAEIPLVVCITEGI 147
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
 
Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 19-344 4.73e-174

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 485.76  E-value: 4.73e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  19 SGLAAARLLSRSFLLpqngirhcSYTASRQHLYVDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQTHL-- 96
Cdd:PTZ00187   1 LKGAAFMILKVSFRA--------RSSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkh 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  97 GLPVFNTVKEAKEQTGATASVIYVPPPFAAAAINEAIEAEIPLVVCITEGIPQQDMVRVKHKLLRQEKTRLIGPNCPGVI 176
Cdd:PTZ00187  73 GLPVFATVKEAKKATGADASVIYVPPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGII 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 177 NPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDSATEGIILIG 256
Cdd:PTZ00187 153 KPGECKIGIMPGHIHKKGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIG 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 257 EIGGNAEENAAEFLKQHnsgPNSKPVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTI 336
Cdd:PTZ00187 233 EIGGTAEEEAAEWIKNN---PIKKPVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTM 309


                 ....*...
gi 109452591 337 YKEFEKRK 344
Cdd:PTZ00187 310 LEVMKKKG 317
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 51-338 2.53e-156

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 439.50  E-value: 2.53e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  51 YVDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAAIN 130
Cdd:COG0074    3 LVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADAIL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 131 EAIEAEIPLVVCITEGIPQQDMVRVKHKLlRQEKTRLIGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAV 210
Cdd:COG0074   83 EAIDAGIKLIVCITEGIPVLDMVRVKRYA-KAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 211 HQTTQVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDSATEGIILIGEIGGNAEENAAEFLKQHnsgpNSKPVVSFIAGLT 290
Cdd:COG0074  162 WQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKEN----MTKPVVAYIAGRT 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 109452591 291 APPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTIYK 338
Cdd:COG0074  238 APPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKK 285
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 51-336 2.65e-155

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 437.30  E-value: 2.65e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  51 YVDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAAIN 130
Cdd:PRK05678   4 LINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAADAIL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 131 EAIEAEIPLVVCITEGIPQQDMVRVKHKLlRQEKTRLIGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAV 210
Cdd:PRK05678  84 EAIDAGIDLIVCITEGIPVLDMLEVKAYL-ERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRSGTLTYEAV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 211 HQTTQVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDSATEGIILIGEIGGNAEENAAEFLKQHnsgpNSKPVVSFIAGLT 290
Cdd:PRK05678 163 AQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKAN----VTKPVVGYIAGVT 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 109452591 291 APPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTI 336
Cdd:PRK05678 239 APPGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELL 284
PLN00125 PLN00125
Succinyl-CoA ligase [GDP-forming] subunit alpha
 44-346 8.29e-154

Succinyl-CoA ligase [GDP-forming] subunit alpha


Pssm-ID: 215066 [Multi-domain]  Cd Length: 300  Bit Score: 434.01  E-value: 8.29e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  44 TASRQHLYVDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYVPPP 123
Cdd:PLN00125   1 ASPPPAVFVDKNTRVICQGITGKNGTFHTEQAIEYGTKMVGGVTPKKGGTEHLGLPVFNTVAEAKAETKANASVIYVPPP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 124 FAAAAINEAIEAEIPLVVCITEGIPQQDMVRVKHKLLRQEKTRLIGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSG 203
Cdd:PLN00125  81 FAAAAILEAMEAELDLVVCITEGIPQHDMVRVKAALNRQSKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRSG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 204 TLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDSATEGIILIGEIGGNAEENAAEFLKqhNSGPNsKPVV 283
Cdd:PLN00125 161 TLTYEAVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFVKDPQTEGIILIGEIGGTAEEDAAAFIK--ESGTE-KPVV 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 109452591 284 SFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTIYKEFEKRKML 346
Cdd:PLN00125 238 AFIAGLTAPPGRRMGHAGAIVSGGKGTAQDKIKALREAGVTVVESPAKIGVAMLEVFKERGLL 300
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 52-336 1.12e-144

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 410.27  E-value: 1.12e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591   52 VDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAAINE 131
Cdd:TIGR01019   3 LDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAIFE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  132 AIEAEIPLVVCITEGIPQQDMVRVKHKLLRQeKTRLIGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVH 211
Cdd:TIGR01019  83 AIDAGIELIVCITEGIPVHDMLKVKRYMEES-GTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAVH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  212 QTTQVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDSATEGIILIGEIGGNAEENAAEFLKQHnsgpNSKPVVSFIAGLTA 291
Cdd:TIGR01019 162 QLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQN----MSKPVVGFIAGATA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 109452591  292 PPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTI 336
Cdd:TIGR01019 238 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELL 282
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 53-146 7.86e-29

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 106.91  E-value: 7.86e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591   53 DKNTKIICQGFTGK--QGT-FHSQQALEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAAI 129
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiQGLnYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 109452591  130 NEAIEAEIPLVVCITEG 146
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 52-147 1.40e-24

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 95.65  E-value: 1.40e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591    52 VDKNTKIICQGFTGKQGTFHSQQA---LEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAA 128
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMrnlLEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 109452591   129 INEAIEAEIPLVVCITEGI 147
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 199-324 1.45e-23

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 94.25  E-value: 1.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  199 VSRSGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDSATEGIILIGEIGGNAEEN-AAEFLKQHN-SG 276
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAFTPTTRIDALKLEAADPEVKVILLDIVLGYGACEDpAGGLLKAIKeAR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 109452591  277 PNSKPVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKISALQSAGVV 324
Cdd:pfam00549  81 ARELPVVARVCGTEADPQGRSGQAKALAESGVLIASSNNQALRAAGAV 128
PLN02522 PLN02522
ATP citrate (pro-S)-lyase
 92-342 2.43e-14

ATP citrate (pro-S)-lyase


Pssm-ID: 178137 [Multi-domain]  Cd Length: 608  Bit Score: 74.09  E-value: 2.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591  92 GQTHLGLPVFNTVKEAKEQTgATASVIYVPPPFAAAAINEAIEAEIP---LVVCITEGIPQQDMVRVkHKLLRQEKTRLI 168
Cdd:PLN02522  57 GQEEIAIPVHGSIEAACKAH-PTADVFINFASFRSAAASSMEALKQPtirVVAIIAEGVPESDTKQL-IAYARANNKVVI 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 169 GPNCPGVINPGECKIG--------IMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFIDCL 240
Cdd:PLN02522 135 GPATVGGIQAGAFKIGdtagtldnIIQCKLYRPGSVGFVSKSGGMSNEMYNVIARVTDGIYEGIAIGGDVFPGSTLSDHV 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 241 EIFLNDSATEGIILIGEIGGNAEENAAEFLKQhnsGPNSKPVVSFIAGLTA---PPGRRMGHAGAIIAGGKGGAKEKISA 317
Cdd:PLN02522 215 LRFNNIPQIKMIVVLGELGGRDEYSLVEALKQ---GKVSKPVVAWVSGTCArlfKSEVQFGHAGAKSGGDMESAQAKNKA 291

                        250       260
                 ....*....|....*....|....*
gi 109452591 318 LQSAGVVVSMSPAQLGTTIYKEFEK 342
Cdd:PLN02522 292 LKDAGAIVPTSFEALEAAIKETFEK 316
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
166-249 9.09e-09

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 56.67  E-value: 9.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 166 RLIGPNCPGVINPGeckIGIM----PGHIhKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGgdpfNGTD--FIDC 239
Cdd:COG1042  128 RLLGPNCLGLINPA---TGLNatfaPVPP-LPGNIALVSQSGALGTAILDWAAARGIGFSHFVSLG----NEADvdFADL 199

                         90
                 ....*....|
gi 109452591 240 LEIFLNDSAT 249
Cdd:COG1042  200 LDYLADDPDT 209
Succ_CoA_lig pfam13607
Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from ...
 193-249 6.11e-05

Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.


Pssm-ID: 433345 [Multi-domain]  Cd Length: 138  Bit Score: 42.45  E-value: 6.11e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 109452591  193 KGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGgdpfNGTD--FIDCLEIFLNDSAT 249
Cdd:pfam13607   1 PGNIALVSQSGALGAALLDWARSRGIGFSKFVSLG----NEADvdFADLLEYLADDPET 55
PRK06091 PRK06091
membrane protein FdrA; Validated
 140-228 9.64e-03

membrane protein FdrA; Validated


Pssm-ID: 180395 [Multi-domain]  Cd Length: 555  Bit Score: 37.72  E-value: 9.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109452591 140 VVCITEGIPQQDMVRVKHKllRQEKTRLI-GPNCpgvinpGECKIGIMP---GHIHKKGRIGIVSRSGTLTYEAVHQTTQ 215
Cdd:PRK06091 144 VMMFSDNVTLEDEIRLKTR--AREKGLLVmGPDC------GTAMIAGTPlafANVMPEGNIGVIGASGTGIQELCSQIAL 215

                         90
                 ....*....|...
gi 109452591 216 VGLGQSLCVGIGG 228
Cdd:PRK06091 216 AGEGITHAIGLGG 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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