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Conserved domains on  [gi|52145305|ref|NP_003729|]
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protein patched homolog 2 isoform 1 [Homo sapiens]

Protein Classification

2A060602 family protein( domain architecture ID 11489962)

2A060602 family protein

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
12-1142 0e+00

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


:

Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 1971.64  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305     12 PSYTPpARTAAPQILAG---SLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVE 88
Cdd:TIGR00918   13 PSYCD-AAFALEQIDKGkatGRRAPLWLRAKFQRLLFTLGCYIQKHCGKVLFVGLLVFSAFAVGLRAANIETNVEQLWVE 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305     89 VGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLI 168
Cdd:TIGR00918   92 VGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPST 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    169 ENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFAS-LEGFRELLDKAQVGQAY 247
Cdd:TIGR00918  172 EGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSqVESWEEMLKKAAVGQGY 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    248 VGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQ 327
Cdd:TIGR00918  252 MERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPKQ 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    328 LYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLA 407
Cdd:TIGR00918  332 MYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLA 411
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    408 YACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPL 487
Cdd:TIGR00918  412 YACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNIPF 491
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    488 QERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCC 567
Cdd:TIGR00918  492 EERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCC 571
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    568 FSSPCSAQVIQILPQELGDG-TVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLL 646
Cdd:TIGR00918  572 FFSPCSARVIQIEPQAYADGsAPPVYSSHMQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQPSDPLSCQSPDIAGSTRDLL 651
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    647 GQEEETrqKAACKSLPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAF 726
Cdd:TIGR00918  652 SQFEDS--KAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDF 729
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    727 LSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRIT 806
Cdd:TIGR00918  730 LDAQFRYFSFYNMYAVTQGNFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQLPRMWLHYFRDWLQGLQKAFDEDWRDGRIT 809
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    807 RHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWL 886
Cdd:TIGR00918  810 KENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAFYIYLSAWVSNDPVAYAASQANIYPHPPEWL 889
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    887 HDKYDTTGENLRIPPAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLL 966
Cdd:TIGR00918  890 HDKNDYDPENLRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSYPSGYPFLFWEQYMGLRHWLLL 969
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    967 AVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGS 1046
Cdd:TIGR00918  970 SISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIGD 1049
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305   1047 RNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKE 1126
Cdd:TIGR00918 1050 RNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLVLLPVLLSMFGPEPEVSPAEGR 1129
                         1130
                   ....*....|....*.
gi 52145305   1127 SPEILSPPAPQGGGLR 1142
Cdd:TIGR00918 1130 SRLPTPSPEPPPGGVR 1145
 
Name Accession Description Interval E-value
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
12-1142 0e+00

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 1971.64  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305     12 PSYTPpARTAAPQILAG---SLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVE 88
Cdd:TIGR00918   13 PSYCD-AAFALEQIDKGkatGRRAPLWLRAKFQRLLFTLGCYIQKHCGKVLFVGLLVFSAFAVGLRAANIETNVEQLWVE 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305     89 VGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLI 168
Cdd:TIGR00918   92 VGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPST 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    169 ENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFAS-LEGFRELLDKAQVGQAY 247
Cdd:TIGR00918  172 EGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSqVESWEEMLKKAAVGQGY 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    248 VGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQ 327
Cdd:TIGR00918  252 MERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPKQ 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    328 LYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLA 407
Cdd:TIGR00918  332 MYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLA 411
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    408 YACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPL 487
Cdd:TIGR00918  412 YACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNIPF 491
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    488 QERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCC 567
Cdd:TIGR00918  492 EERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCC 571
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    568 FSSPCSAQVIQILPQELGDG-TVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLL 646
Cdd:TIGR00918  572 FFSPCSARVIQIEPQAYADGsAPPVYSSHMQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQPSDPLSCQSPDIAGSTRDLL 651
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    647 GQEEETrqKAACKSLPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAF 726
Cdd:TIGR00918  652 SQFEDS--KAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDF 729
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    727 LSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRIT 806
Cdd:TIGR00918  730 LDAQFRYFSFYNMYAVTQGNFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQLPRMWLHYFRDWLQGLQKAFDEDWRDGRIT 809
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    807 RHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWL 886
Cdd:TIGR00918  810 KENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAFYIYLSAWVSNDPVAYAASQANIYPHPPEWL 889
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    887 HDKYDTTGENLRIPPAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLL 966
Cdd:TIGR00918  890 HDKNDYDPENLRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSYPSGYPFLFWEQYMGLRHWLLL 969
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    967 AVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGS 1046
Cdd:TIGR00918  970 SISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIGD 1049
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305   1047 RNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKE 1126
Cdd:TIGR00918 1050 RNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLVLLPVLLSMFGPEPEVSPAEGR 1129
                         1130
                   ....*....|....*.
gi 52145305   1127 SPEILSPPAPQGGGLR 1142
Cdd:TIGR00918 1130 SRLPTPSPEPPPGGVR 1145
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
418-570 5.47e-50

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 173.92  E-value: 5.47e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    418 CAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQR 497
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52145305    498 TGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSS 570
Cdd:pfam12349   81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
384-1085 1.34e-23

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 108.02  E-value: 1.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  384 DDILHAFSEVSAARVVGGYLLMLAYACVTMLRWdcaqsqgSVGLAGVLLVALAVASGLGLCALLGITFNAATTqVLPFLA 463
Cdd:COG1033  210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL-------RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLL 281
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  464 LGIGVDD-VFLLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAV 542
Cdd:COG1033  282 LAIGIDYgIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS 361
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  543 MLVFPAILSLdlrrrhcqrldvlccfsspcsaqviqilpqelgdgtvpvgiahltatvqafthceassqhvvtiLPPQAH 622
Cdd:COG1033  362 LTLLPALLSL----------------------------------------------------------------LPRPKP 377
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  623 LVPPPSDPLGSELFSPGgstrdllgqeeetrqkaackslpcarwnLAHFARyqfaplllqsHAKAIVLVLFGALLGLSLY 702
Cdd:COG1033  378 KTRRLKKPPELGRLLAK----------------------------LARFVL----------RRPKVILVVALVLAVVSLY 419
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  703 GATLVQDGLALTDVVPRGT---KEHAFLSAQLRYFSLYEVAL--VTQGGFDYAHSQRALFDLHQRFSSLKAVLpppATQA 777
Cdd:COG1033  420 GISRLKVEYDFEDYLPEDSpirQDLDFIEENFGGSDPLEVVVdtGEPDGLKDPEVLKEIDRLQDYLESLPEVG---KVLS 496
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  778 PRTWLHYYRnwlqgiQAAFDQDWASGRITRhsyrngSEDGALAYKLLIQTGDAQEpldfsqltTRKLVDREGLippelfY 857
Cdd:COG1033  497 LADLVKELN------QALNEGDPKYYALPE------SRELLAQLLLLLSSPPGDD--------LSRFVDEDYS------A 550
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  858 MGLTVWVSsdplglaasqanfyppppewlhdkyDTTGENLRippaqplefaqfpfllrglqktaDFVEAIEgaRAACAEA 937
Cdd:COG1033  551 ARVTVRLK-------------------------DLDSEEIK-----------------------ALVEEVR--AFLAENF 580
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  938 GQAGVHAYPSGSPFLF--WEQYL--GLRRCFLLAvcILLVctFLVCALLLLNpWTAGLIVLVLAMMTVEL-FGIMGFLGI 1012
Cdd:COG1033  581 PPDGVEVTLTGSAVLFaaINESVieSQIRSLLLA--LLLI--FLLLLLAFRS-LRLGLISLIPNLLPILLtFGLMGLLGI 655
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52145305 1013 KLSAIPVVILVASVGIGVEFTVHVALGFLT-TQGSRNLRAA--HALEHTFAPVTDGAISTLLGLLMLAGSHFDFIV 1085
Cdd:COG1033  656 PLNIATAVVASIALGIGVDYTIHFLSRYREeRRKGGDLEEAirRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLA 731
 
Name Accession Description Interval E-value
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
12-1142 0e+00

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 1971.64  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305     12 PSYTPpARTAAPQILAG---SLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVE 88
Cdd:TIGR00918   13 PSYCD-AAFALEQIDKGkatGRRAPLWLRAKFQRLLFTLGCYIQKHCGKVLFVGLLVFSAFAVGLRAANIETNVEQLWVE 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305     89 VGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLI 168
Cdd:TIGR00918   92 VGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPST 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    169 ENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFAS-LEGFRELLDKAQVGQAY 247
Cdd:TIGR00918  172 EGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSqVESWEEMLKKAAVGQGY 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    248 VGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQ 327
Cdd:TIGR00918  252 MERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPKQ 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    328 LYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLA 407
Cdd:TIGR00918  332 MYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLA 411
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    408 YACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPL 487
Cdd:TIGR00918  412 YACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNIPF 491
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    488 QERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCC 567
Cdd:TIGR00918  492 EERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCC 571
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    568 FSSPCSAQVIQILPQELGDG-TVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLL 646
Cdd:TIGR00918  572 FFSPCSARVIQIEPQAYADGsAPPVYSSHMQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQPSDPLSCQSPDIAGSTRDLL 651
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    647 GQEEETrqKAACKSLPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAF 726
Cdd:TIGR00918  652 SQFEDS--KAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDF 729
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    727 LSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRIT 806
Cdd:TIGR00918  730 LDAQFRYFSFYNMYAVTQGNFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQLPRMWLHYFRDWLQGLQKAFDEDWRDGRIT 809
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    807 RHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWL 886
Cdd:TIGR00918  810 KENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAFYIYLSAWVSNDPVAYAASQANIYPHPPEWL 889
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    887 HDKYDTTGENLRIPPAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLL 966
Cdd:TIGR00918  890 HDKNDYDPENLRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSYPSGYPFLFWEQYMGLRHWLLL 969
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    967 AVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGS 1046
Cdd:TIGR00918  970 SISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIGD 1049
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305   1047 RNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKE 1126
Cdd:TIGR00918 1050 RNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLVLLPVLLSMFGPEPEVSPAEGR 1129
                         1130
                   ....*....|....*.
gi 52145305   1127 SPEILSPPAPQGGGLR 1142
Cdd:TIGR00918 1130 SRLPTPSPEPPPGGVR 1145
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
38-1089 3.98e-50

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 194.36  E-value: 3.98e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305     38 AYFQGLLFSL----GCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGeeAAYTSQ 113
Cdd:TIGR00917  303 STVQGHLARFfgkyGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFG--PFYRIE 380
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    114 MLIQTARQEGEN-----ILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLieNGMIERMIEKLFPcviltp 188
Cdd:TIGR00917  381 QLIIATVQTSSHekapeILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPY--NCFIYSTCKKLQN------ 452
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    189 ldcfwegaklqggsaylpgrpdiQWTNLDPEQLlEELGPFASLEGFRELLdkaqvgqayvgrpcLHPDDLHCPPSAPnhh 268
Cdd:TIGR00917  453 -----------------------MYSKLKPENY-DDYGGVDYVKYCFEHF--------------TSPESCLSAFGGP--- 491
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    269 srqapnvahelsggchgfshkfmhWQEELLLGGMARDPQGEllrAEALQSTFLLmsprqlyehfrgdyqthDIGWSEEQA 348
Cdd:TIGR00917  492 ------------------------VDPTTVLGGFSGNNFSE---ASAFVVTFPV-----------------NNFVNKTNK 527
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    349 STVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTM-----LRWDCAQSQG 423
Cdd:TIGR00917  528 TEKAVAWEKAFIQLAKDELLPMVQATISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLgdsprLKSLYVTSKV 607
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    424 SVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAF-----------TEALPGTPLQERMG 492
Cdd:TIGR00917  608 LLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqvgVDNEQELTLERRLS 687
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    493 ECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSspc 572
Cdd:TIGR00917  688 RALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIK--- 764
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    573 saqviqilpqeLGDGtvpvGIAHLTATVQAFTHCeassqhvvtilppqahlvpppsdplgselfspggstrdllgqeeet 652
Cdd:TIGR00917  765 -----------TSKS----SISAEKGSGQRKAGL---------------------------------------------- 783
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    653 rqkaackslpcarwnLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTK-EHAFLSAQL 731
Cdd:TIGR00917  784 ---------------LTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYlQIYFASLTP 848
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    732 RYFSLYEVALVTQGGFDYAHSQ---RALFDLHQRFSSLKAVLP--PPATQAPRTWLHYYRNWLQGIQAAFDQDWASGrit 806
Cdd:TIGR00917  849 LLEVGPPFYIVIKGDYNYTDFEsqnKLCTMGGCDKDSIVNVFNnlSYIAKPASSWLDDYLVWLSPQASCCCRKFTNG--- 925
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    807 rhSYRNGSEDGALAYKLLIQTGDAQ-EPLDFSQLTTRKLVDregLIPPELFYMGLTVWVSSDPLGLAAS--QANFYpppp 883
Cdd:TIGR00917  926 --TFCNGPDPQCFRCADLSSDAQGRpSTTQFKEKLPWFLNA---LPSADCAKGGHAAYSSAVDLQGYATiiQASSF---- 996
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    884 ewlhDKYDTTgenlrippaqplefaqfpfllrgLQKTADFVEAIEGARAACAEAGQ-AGVHAYPSGSPFLFWEQYLGLRR 962
Cdd:TIGR00917  997 ----RTYHTP-----------------------LNTQVDFINAMRAAQEFAAKVSRsSKMEVYPYSVFYVFFEQYLTIWK 1049
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    963 CFLLAVCILLVCTFLVCALLL-LNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFL 1041
Cdd:TIGR00917 1050 TAIINLSIALGAIFIVCLFLLqLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFS 1129
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|
gi 52145305   1042 TT-QGSRNLRAAHALEHTFAPVTDG-AISTLLGLLMLAGSHFDFIVRYFF 1089
Cdd:TIGR00917 1130 TGkHFSRNHRAKEALGGMGSSVFSGiTLTKLVGVVVLGFSRSEIFVVYYF 1179
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
418-570 5.47e-50

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 173.92  E-value: 5.47e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    418 CAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQR 497
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52145305    498 TGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSS 570
Cdd:pfam12349   81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
374-1077 4.74e-43

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 169.46  E-value: 4.74e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    374 QIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVT-----MLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLG 448
Cdd:pfam02460  195 QFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVsvtlsSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMG 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    449 ITFNAATTqVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFS 528
Cdd:pfam02460  275 FPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFC 353
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    529 LQAAIVVGCTFVAVMLVFPAILSLDLRRrhcqrldvlccfsspcsaqviqilpqelgdgtvpvgiahltatvqafthcEA 608
Cdd:pfam02460  354 AYTAVAIFFDFIYQITFFAAIMAICAKP--------------------------------------------------EA 383
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    609 SSQHVVtilppqahLVPPPSDPlgSELFSpggstrdllgqeEETRQKAACKSLPCARwnlaHFARYQFAPLLLQSHAKAI 688
Cdd:pfam02460  384 EGRHCL--------FVWATSSP--QRIDS------------EGSEPDKSHNIEQLKS----RFFLDIYCPFLLNPSVRVC 437
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    689 VLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQ----LRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFS 764
Cdd:pfam02460  438 MLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLRekhfWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFE 517
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    765 SLKAVLPPPATQaprTWLHYYRNWLQGIQAAFDQDwasgritrhsyrngsedgalayklliqtgdaqepldfsqlttrkl 844
Cdd:pfam02460  518 NTPYSLGPNSTL---FWLREYENFLSTLNMEEEED--------------------------------------------- 549
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    845 vdreglIPPELFYMGLTVWvssdplgLAASqanFYPPppeWLHDKY--DTTGEnlrippaqpLEFAQFPFLLRGLQKTAD 922
Cdd:pfam02460  550 ------EEKEWSYGNLPSF-------LKAP---GNSH---WAGDLVwdDNTTM---------VTKFRFTLAGKGLSTWND 601
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    923 FVEAIEGARAACAEAGQAGVHAYPSGSPFLfwEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVE 1002
Cdd:pfam02460  602 RTRALQEWRSIADQYPEFNVTVFDEDAPFA--DQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIG 679
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52145305   1003 LFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSR-NLRAAHALEHTFAPVTDGAISTLLGLLMLA 1077
Cdd:pfam02460  680 VFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTpAERVVDALEALGWPVFQGGLSTILGVLVLL 755
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
384-1085 1.34e-23

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 108.02  E-value: 1.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  384 DDILHAFSEVSAARVVGGYLLMLAYACVTMLRWdcaqsqgSVGLAGVLLVALAVASGLGLCALLGITFNAATTqVLPFLA 463
Cdd:COG1033  210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL-------RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLL 281
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  464 LGIGVDD-VFLLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAV 542
Cdd:COG1033  282 LAIGIDYgIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS 361
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  543 MLVFPAILSLdlrrrhcqrldvlccfsspcsaqviqilpqelgdgtvpvgiahltatvqafthceassqhvvtiLPPQAH 622
Cdd:COG1033  362 LTLLPALLSL----------------------------------------------------------------LPRPKP 377
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  623 LVPPPSDPLGSELFSPGgstrdllgqeeetrqkaackslpcarwnLAHFARyqfaplllqsHAKAIVLVLFGALLGLSLY 702
Cdd:COG1033  378 KTRRLKKPPELGRLLAK----------------------------LARFVL----------RRPKVILVVALVLAVVSLY 419
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  703 GATLVQDGLALTDVVPRGT---KEHAFLSAQLRYFSLYEVAL--VTQGGFDYAHSQRALFDLHQRFSSLKAVLpppATQA 777
Cdd:COG1033  420 GISRLKVEYDFEDYLPEDSpirQDLDFIEENFGGSDPLEVVVdtGEPDGLKDPEVLKEIDRLQDYLESLPEVG---KVLS 496
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  778 PRTWLHYYRnwlqgiQAAFDQDWASGRITRhsyrngSEDGALAYKLLIQTGDAQEpldfsqltTRKLVDREGLippelfY 857
Cdd:COG1033  497 LADLVKELN------QALNEGDPKYYALPE------SRELLAQLLLLLSSPPGDD--------LSRFVDEDYS------A 550
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  858 MGLTVWVSsdplglaasqanfyppppewlhdkyDTTGENLRippaqplefaqfpfllrglqktaDFVEAIEgaRAACAEA 937
Cdd:COG1033  551 ARVTVRLK-------------------------DLDSEEIK-----------------------ALVEEVR--AFLAENF 580
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  938 GQAGVHAYPSGSPFLF--WEQYL--GLRRCFLLAvcILLVctFLVCALLLLNpWTAGLIVLVLAMMTVEL-FGIMGFLGI 1012
Cdd:COG1033  581 PPDGVEVTLTGSAVLFaaINESVieSQIRSLLLA--LLLI--FLLLLLAFRS-LRLGLISLIPNLLPILLtFGLMGLLGI 655
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52145305 1013 KLSAIPVVILVASVGIGVEFTVHVALGFLT-TQGSRNLRAA--HALEHTFAPVTDGAISTLLGLLMLAGSHFDFIV 1085
Cdd:COG1033  656 PLNIATAVVASIALGIGVDYTIHFLSRYREeRRKGGDLEEAirRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLA 731
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
424-561 3.26e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 84.14  E-value: 3.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  424 SVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPfLALGIGVDDVFLLAHAFTEAL-PGTPLQERMGECLQRTGTSV 502
Cdd:COG1033  630 RLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYTIHFLSRYREERrKGGDLEEAIRRALRTTGKAI 708
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 52145305  503 VLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLdLRRRHCQR 561
Cdd:COG1033  709 LFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLL-LDPRIAKK 766
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
909-1088 3.44e-14

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 77.59  E-value: 3.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  909 QFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWT 988
Cdd:COG1033  165 VVTLDPDPLSSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRG 244
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  989 AGLIVLVLAMMTVELFGIMGFLGIKLS----AIPVVILvasvGIGVEFTVHVALGF---LTTQGSRNLRAAHALEHTFAP 1061
Cdd:COG1033  245 VLLPLLVVLLAVIWTLGLMGLLGIPLSpltiLVPPLLL----AIGIDYGIHLLNRYreeRRKGLDKREALREALRKLGPP 320
                        170       180
                 ....*....|....*....|....*..
gi 52145305 1062 VTDGAISTLLGLLMLAGSHFDfIVRYF 1088
Cdd:COG1033  321 VLLTSLTTAIGFLSLLFSDIP-PIRDF 346
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
425-552 1.52e-08

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 59.08  E-value: 1.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    425 VGLAGVLLVALAVasgLGLCALLGITFNAaTTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVL 504
Cdd:TIGR00921  596 FPLIAIGSGILWA---IGLMGLRGIPSFL-AMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILF 671
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 52145305    505 TSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSL 552
Cdd:TIGR00921  672 SGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
423-557 1.63e-08

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 59.01  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  423 GSVGLAGV--LLVALAVASGLGLCALLG--ITFNAATTQVLPFLALGIGVD-DVFLLAhAFTEALP-GTPLQERMGECLQ 496
Cdd:COG2409  191 RSLVAALLplLTAGLAVGVALGLLALLAafTDVSSFAPNLLTMLGLGVGIDyALFLVS-RYREELRaGEDREEAVARAVA 269
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 52145305  497 RTGTSVV---LTSInnmAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLdLRRR 557
Cdd:COG2409  270 TAGRAVLfsgLTVA---IALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPALLAL-LGRR 329
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
357-550 2.24e-08

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 58.47  E-value: 2.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    357 RRFVQLAQEALPENASQQIHAFSSTtlDDILHAFSEVSAARVVGGYLLMLayacVTMLRW-DCAqsqgsVGLAGVLLVAL 435
Cdd:TIGR03480  683 RRFVRAVRKVAPDATGAPVSILESG--DTVVGAFLQAFIYALVAITVLLL----LTLRRVrDVL-----LVLAPLLLAGL 751
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    436 AVasgLGLCALLGITFNAATTQVLPFLaLGIGVDDVFLLAHAFTEA-LPGTPLQermgeclQRTGTSVVLTSINNMAAFL 514
Cdd:TIGR03480  752 LT---VAAMVLLGIPFNFANIIALPLL-LGLGVDFGIYMVHRWRNGvDSGNLLQ-------SSTARAVFFSALTTATAFG 820
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 52145305    515 MAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAIL 550
Cdd:TIGR03480  821 SLAVSSHPGTASMGILLSLGLGLTLLCTLIFLPALL 856
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
426-552 4.18e-08

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 57.54  E-value: 4.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    426 GLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLaLGIGVD-DVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVL 504
Cdd:TIGR00921  220 PLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPML-IGVGIDyGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLI 298
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 52145305    505 TSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSL 552
Cdd:TIGR00921  299 ALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQS 346
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
941-1084 2.39e-06

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 51.76  E-value: 2.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    941 GVHAYPSGSPFLFWEQY----LGLRRcfllavcILLVCTFLVCALLLL---NPWTAglIVLVLAMMTVELF--GIMGFLG 1011
Cdd:TIGR00921  546 GVKVGVTGLPVAFAEMHelvnEGMRR-------MTIAGAILVLMILLAvfrNPIKA--VFPLIAIGSGILWaiGLMGLRG 616
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52145305   1012 IKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAA--HALEHTFAPVTDGAISTLLGLLMLAGSHFDFI 1084
Cdd:TIGR00921  617 IPSFLAMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAitHTMERTGPGILFSGLTTAGGFLSLLLSHFPIM 691
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
941-1087 3.77e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 47.91  E-value: 3.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305    941 GVHAYPSGSPFLFWEQYLGLRRCF--LLAVCILLVCTFLvcaLLLLNPWTAGLIVLVLAMMTVEL-FGIMGFLGIKLSAI 1017
Cdd:TIGR00921  172 GKFLDVTGSPAINYDIEREFGKDMgtTMAISGILVVLVL---LLDFKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYAT 248
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52145305   1018 PVVILVASVGIGVEFTVHVALGFLTTQG-SRNLRAA--HALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRY 1087
Cdd:TIGR00921  249 TLLAVPMLIGVGIDYGIQTLNRYEEERDiGRAKGEAivTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEF 321
COG4258 COG4258
Predicted exporter [General function prediction only];
965-1080 2.94e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 45.23  E-value: 2.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  965 LLAVCILLVctFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVhvalgFLTtq 1044
Cdd:COG4258  644 LLLLALLLI--LLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYAL-----FFT-- 714
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 52145305 1045 gsRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSH 1080
Cdd:COG4258  715 --EGLLDKGELARTLLSILLAALTTLLGFGLLAFSS 748
COG4258 COG4258
Predicted exporter [General function prediction only];
376-548 4.97e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 44.46  E-value: 4.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  376 HAFSSTTLDDILHAFSEVSAArvvgGYLLMLAYACVTMLRWdcaqsqgSVGLAGVLLVALAVASGLGLCALLGITFNAAT 455
Cdd:COG4258  627 KAESSSLFGRYRNDALWLLLL----ALLLILLLLLLRLRSL-------RRALRVLLPPLLAVLLTLAILGLLGIPLNLFH 695
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  456 TQVLpFLALGIGVD-DVFllahaFTEALPGtplqermGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIV 534
Cdd:COG4258  696 LIAL-LLVLGIGIDyALF-----FTEGLLD-------KGELARTLLSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLG 762
                        170
                 ....*....|....
gi 52145305  535 VGCTFVAVMLVFPA 548
Cdd:COG4258  763 ILLALLLAPLLAPR 776
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
427-552 4.14e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 41.29  E-value: 4.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52145305  427 LAGVLLVALAVASGLGLCA--------LLGITFNAATTQVLPFL---ALGIGVD-DVFLLAHAFTEALPGTPLQERMGEC 494
Cdd:COG2409  545 LKAVLTNLLSLGAALGVLVlvfqhgwlLLGFTPGPLDSFVPLLLfviLFGLGMDyEVFLVSRIREEYDRGGGTREAVIRG 624
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52145305  495 LQRTGtSVVlTSinnmAAFLMAA------LVPIPALR--AFSLQAAIVVGCTFVAVMLVfPAILSL 552
Cdd:COG2409  625 LARTG-RVI-TS----AALIMAAvfaafaTSPLVFLKqiGFGLAVGVLLDAFVVRMLLV-PALMAL 683
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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