BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  16 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLM 95
Cdd:cd18221   1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLM 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 84872173  96 IQGEEEANDVWKAAEFLQMLEAIKALEVRNKEN 128
Cdd:cd18221  81 VQGEEEANDVWKAAEYLQMQEAIKALEFRNKES 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  16 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLM 95
Cdd:cd18221   1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLM 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 84872173  96 IQGEEEANDVWKAAEFLQMLEAIKALEVRNKEN 128
Cdd:cd18221  81 VQGEEEANDVWKAAEYLQMQEAIKALEFRNKES 113

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173     35 DITLIVDGHHFKAHKAVLAACSKFFYKFFQ---EFTQEPLVEIEGVSKMAFRHLIEFTYTAKLMIQgEEEANDVWKAAEF 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSsdfKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLP-EENVEELLELADY 79

                           90
                   ....*....|.
gi 84872173    112 LQMLEAIKALE 122
Cdd:smart00225  80 LQIPGLVELCE 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  16 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLM 95
Cdd:cd18221   1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLM 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 84872173  96 IQGEEEANDVWKAAEFLQMLEAIKALEVRNKEN 128
Cdd:cd18221  81 VQGEEEANDVWKAAEYLQMQEAIKALEFRNKES 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  33 FTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQE---PLVEIEGVSKMAFRHLIEFTYTAKLMIQgEEEANDVWKAA 109
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKEsssSEIELDDVSPEAFEALLDYIYTGELELS-EENVEELLAAA 79

                ...
gi 84872173 110 EFL 112
Cdd:cd18186  80 DKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  12 EFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEftQEPLVEIEGVSKMAFRHLIEFTYT 91
Cdd:cd18206   1 DFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVD--QKDVVHLDISNAAGLGQVLEFMYT 78

                        90       100       110
                ....*....|....*....|....*....|.
gi 84872173  92 AKLMIQgEEEANDVWKAAEFLQMLEAIKALE 122
Cdd:cd18206  79 AKLSLS-PENVDDVLAVATFLQMQDIVTACH 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  16 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQE----FTQEPLVEIEGVSKMAFRHLIEFTYT 91
Cdd:cd18202   2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEkgavSSHEAVVDLSGFCKSSFLPLLEFAYT 81

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 84872173  92 AKLMIQGEEEAnDVWKAAEFLQMLEAIKALEVRNKE 127
Cdd:cd18202  82 SELTFDFCSMA-EVAMLARHLFMNEVLEICESVHKQ 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  12 EFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQE-FTQEPLVEIEG--VSKMAFRHLIEF 88
Cdd:cd18194   2 EFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDrLDKRDLVRLNSdiVTAPAFGLLLDF 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 84872173  89 TYTAKLMIQgEEEANDVWKAAEFLQMLEAIKALEVRNKENSAPLEENT 136
Cdd:cd18194  82 MYEGRLALR-DLPVEDVLAAASYLHMYDIVKVCKGRLQEKALAEADST 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  12 EFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQ-EFTQEPLVEIEG--VSKMAFRHLIEF 88
Cdd:cd18324   2 EFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKdQLDKRDIVHLNSdiVTAPAFALLLEF 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84872173  89 TYTAKLMIQGeEEANDVWKAAEFLQMLEAIKALEVRNKENSapleenTTGKNEAKKRKIAETSNVITESLPSA 161
Cdd:cd18324  82 MYEGKLQFKD-LPIEDVLAAASYLHMYDIVKVCKKKLKEKA------TTEADSTKKEEDASSCSDKVESFSSG 147

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173     35 DITLIVDGHHFKAHKAVLAACSKFFYKFFQ---EFTQEPLVEIEGVSKMAFRHLIEFTYTAKLMIQgEEEANDVWKAAEF 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSsdfKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLP-EENVEELLELADY 79

                           90
                   ....*....|.
gi 84872173    112 LQMLEAIKALE 122
Cdd:smart00225  80 LQIPGLVELCE 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  15 EHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFY-KFFQEFT---------QEPLVEIEGVSKMAFRH 84
Cdd:cd18228   1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRsKLVGQASprlvlvspaGKCVLDLHHVTVTGFAP 80

                        90       100       110
                ....*....|....*....|....*....|
gi 84872173  85 LIEFTYTAKLMIQgEEEANDVWKAAEFLQM 114
Cdd:cd18228  81 LLEYAYTSTLSIN-TENIIDVLAAASYMQM 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  16 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQE-PLVEIEGVSKMAFRHLIEFTYTAKL 94
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNiVFLDQSQVSADGFQKLLEFIYTGNL 80

                        90       100
                ....*....|....*....|....*...
gi 84872173  95 MIQGEEEAnDVWKAAEFLQMLEAIKALE 122
Cdd:cd18217  81 NLDSWNVA-EIHQAASYLGMEEVVAKCK 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  12 EFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQ-EFTQEPLVEIEG--VSKMAFRHLIEF 88
Cdd:cd18325   2 EFPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRdQLDKRDIVHLNSdiVTAPAFSLLLEF 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 84872173  89 TYTAKLMIQgEEEANDVWKAAEFLQMLEAIKALEVRNKENSAPLEE 134
Cdd:cd18325  82 MYEGKLEFS-SLPVEDVLAAASYLHMYDIVKVCKGKLKDKELCSEE 126

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  33 FTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEI--EGVSKMAFRHLIEFTYTAKlMIQGEEEANDVWKAAE 110
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIilPDVPYSELKALLDFIYTGE-VNVSQEQLESLLKLAE 79

                ...
gi 84872173 111 FLQ 113
Cdd:cd18315  80 LLQ 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  16 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEP---LVEIEGVSKMAFRHLIEFTYTA 92
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGvsvLTLPSGLEARGFQLLLDFMYTS 81

                        90       100
                ....*....|....*....|..
gi 84872173  93 KLMIQgEEEANDVWKAAEFLQM 114
Cdd:cd18332  82 RLPLT-PRTVPAVLAAATYLQM 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  16 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKmAFRHLIEFTYTAKLM 95
Cdd:cd18232   1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAE-VFGLLLDFFYTGELA 79

                        90       100
                ....*....|....*....|...
gi 84872173  96 IQgEEEANDVWKAAEFLQMLEAI 118
Cdd:cd18232  80 LT-RENRDRVLLAAKELRVPEAV 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173   9 CLQeFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQE--------FTQEPLVEIEGvskm 80
Cdd:cd18331   1 CIQ-FTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDqlkcnlsvINLDPEINPEG---- 75

                        90       100       110
                ....*....|....*....|....*....|....
gi 84872173  81 aFRHLIEFTYTAKLMIQgEEEANDVWKAAEFLQM 114
Cdd:cd18331  76 -FNILLDFMYTSRLNLR-EGNIMAVMATAMYLQM 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  16 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQ--EPLVEIEGVSKMAFRHLIEFTYTAK 93
Cdd:cd18212   6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEvgQSIYMLEGMVAETFGALLEFIYTGC 85

                        90       100
                ....*....|....*....|....*....
gi 84872173  94 LMIqGEEEANDVWKAAEFLQMLEAIKALE 122
Cdd:cd18212  86 LQV-GEKSLEQILATAQFLKVNDLVKAYS 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173   9 CLqefPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPL---VEIEGVSKMAFRHL 85
Cdd:cd18259  11 CL---PSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESIsarVEIKDVDPAVMESL 87

                        90
                ....*....|....*...
gi 84872173  86 IEFTYTAKLMI-QGEEEA 102
Cdd:cd18259  88 IDFAYTGKLTInQGNVEA 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  13 FPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEP----------LVEIEGVSKMAF 82
Cdd:cd18327   5 FPEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSgdlgagggqdVCELDFVGPEAL 84

                        90       100       110
                ....*....|....*....|....*....|..
gi 84872173  83 RHLIEFTYTAKLMIQgEEEANDVWKAAEFLQM 114
Cdd:cd18327  85 GALLEFAYTATLTIS-SSNMREVLRAARLLEI 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  16 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFF----YKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYT 91
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFrmllSHYIQDTGRPSTASFDVFSSDAFSIILDFVYS 80

                        90       100
                ....*....|....*....|....*..
gi 84872173  92 AKLMIQGeEEANDVWKAAEFLQMLEAI 118
Cdd:cd18199  81 GKLSLTS-QNVIEVMSAASYLQMTDVI 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  14 PEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFT----QEPLVEIEGVSKMAFRHLIEFT 89
Cdd:cd18230   2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQktsdQATVTHLDIVTAQGFKAIIDFM 81

                        90       100       110
                ....*....|....*....|....*....|.
gi 84872173  90 YTAKLMIQgEEEANDVWKAAEFLQMLEAIKA 120
Cdd:cd18230  82 YSAHLALT-SKNVIEVMSAASYLQMTDIVQA 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  14 PEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEP---LVEIEGVSKMAFRHLIEFTY 90
Cdd:cd18235   2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESranRVTLQDVDGKALLLLIDYVY 81

                        90       100
                ....*....|....*....|....*.
gi 84872173  91 TAKLMIQgEEEANDVWKAAEFLQMLE 116
Cdd:cd18235  82 TAEIQVT-EENVQVLLPAANLLQLTD 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  16 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEP---LVEIEGVSKMAFRHLIEFTYTA 92
Cdd:cd18264  11 HGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESkarVIHLPVVSAAGLQRVLDFIYTS 90

                        90       100
                ....*....|....*....|....*..
gi 84872173  93 KLMIQgEEEANDVWKAAEFLQMLEAIK 119
Cdd:cd18264  91 WLSLS-LDTLEDTLEAASYLQVTEAIG 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  12 EFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYT 91
Cdd:cd18289   8 EIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPACFQQILSFCYT 87

                        90       100
                ....*....|....*....|...
gi 84872173  92 AKLMIQGEEEANDVWKAAeFLQM 114
Cdd:cd18289  88 GKLTMAASEQLVVMYTAG-FLQI 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  13 FPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEI-----EGVSKMAFRHLIE 87
Cdd:cd18196   1 FPGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMiqldsEVVTAEAFAALID 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 84872173  88 FTYTAKLMIqGEEEANDVWKAAEFLQMLEAIKA 120
Cdd:cd18196  81 MMYTSTLML-GESNVMDVLLAASHLHLNSVVKA 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  13 FPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFfqeFTQEPLVEIEG--VSKMAFRHLIEFTY 90
Cdd:cd18334   1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSL---VLHDNLINLDTdmVNPTVFRQILDFIY 77

                        90       100
                ....*....|....*....|....*..
gi 84872173  91 TAKLMIQ---GEEEANDVWKAAEFLQM 114
Cdd:cd18334  78 TGKLLTSdqpGEQNFNALLTAASYLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84872173  15 EHHKMILDRLNEQREQD-RFTDITLIVDGHHFKAHKAVLAACSKFFYKFF----QEFTQEPLVEIEGVSKMAFRHLIEFT 89
Cdd:cd18207   8 QHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFsaqeGDGGTPRELEMHTISSKVFGDILDFA 87

                        90       100
                ....*....|....*....|....*....
gi 84872173  90 YTAKLMIQgEEEANDVWKAAEFLQMLEAI 118
Cdd:cd18207  88 YTSRIVVR-LESFPELMTAAKFLLMRSVI 115