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Conserved domains on  [gi|4507533|ref|NP_003257|]
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toll-like receptor 4 isoform C [Homo sapiens]

Protein Classification

toll-like receptor( domain architecture ID 17988233)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
634-775 3.24e-34

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 127.44  E-value: 3.24e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533     634 YDAFVIYSSQDedWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEI 713
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEI-DEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4507533     714 AQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNtYLEWEDSVLGRhiFWRRLRKAL 775
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN-YLKWPEDEKEQ--FWKKALYAV 137
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
250-541 3.66e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 3.66e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  250 LAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSE 329
Cdd:COG4886  13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  330 VDLPSLEFLDLSRNGLSFKgccsqsdfgTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEfsVFLSLRNL 409
Cdd:COG4886  93 GDLTNLTELDLSGNEELSN---------LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  410 IYLDISHTHTRVAFNGIFNgLSSLEVLKMAGNSFQEnfLPDIFTELRNLTFLDLSQCQLEQLsPTAFNSLSSLQVLNMSH 489
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSN 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4507533  490 NNFFSLDTFpyKCLNSLQVLDYSLNHIMT-SKKQELQhfpsSLAFLNLTQNDF 541
Cdd:COG4886 238 NQLTDLPEL--GNLTNLEELDLSNNQLTDlPPLANLT----NLKTLDLSNNQL 284
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
3-158 3.44e-08

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 3.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533    3 LNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPiqslalgAF 82
Cdd:COG4886  37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------EL 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   83 SGLSSLQKLVAVETNLASLENFpIGHLKTLKELNVAHNLIQSfkLPEYFSNLTNLEHLDLSSNKIQSI-----YCTDLRV 157
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLpeelgNLTNLKE 186


                .
gi 4507533  158 L 158
Cdd:COG4886 187 L 187
LRRCT smart00082
Leucine rich repeat C-terminal domain;
539-585 6.79e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 6.79e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4507533     539 NDFACTCEHQSFLQWIKDQRQLLvEVERMECATPSDKQGmPVLSLNI 585
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ-DPVDLRCASPSSLRG-PLLELLH 45
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
634-775 3.24e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 127.44  E-value: 3.24e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533     634 YDAFVIYSSQDedWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEI 713
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEI-DEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4507533     714 AQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNtYLEWEDSVLGRhiFWRRLRKAL 775
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN-YLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-776 1.54e-32

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 123.63  E-value: 1.54e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533    637 FVIYSS----QDEDWVRNELVKNLeeGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYE 712
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533    713 IAQTWQfLSSRAGIIFIVLQKVEK-------TLLRQQVELYRLLSRNTYLEWE------------DSVLGRHIFWRRLRK 773
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156


                  ...
gi 4507533    774 ALL 776
Cdd:pfam01582 157 DIS 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
250-541 3.66e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 3.66e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  250 LAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSE 329
Cdd:COG4886  13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  330 VDLPSLEFLDLSRNGLSFKgccsqsdfgTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEfsVFLSLRNL 409
Cdd:COG4886  93 GDLTNLTELDLSGNEELSN---------LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  410 IYLDISHTHTRVAFNGIFNgLSSLEVLKMAGNSFQEnfLPDIFTELRNLTFLDLSQCQLEQLsPTAFNSLSSLQVLNMSH 489
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSN 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4507533  490 NNFFSLDTFpyKCLNSLQVLDYSLNHIMT-SKKQELQhfpsSLAFLNLTQNDF 541
Cdd:COG4886 238 NQLTDLPEL--GNLTNLEELDLSNNQLTDlPPLANLT----NLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 7-492 4.95e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.43  E-value: 4.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533     7 KIPDN---LPFSTKNLDLSFNPLRhlGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFS 83
Cdd:PLN00113 108 PIPDDiftTSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533    84 GLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIqSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPL 163
Cdd:PLN00113 186 NLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQY 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   164 LNLSLDLSLNPmnfIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQgLAGLEVHRLvlgeFRNegnleKFDKSALEGLCNL 243
Cdd:PLN00113 265 LFLYQNKLSGP---IPPSIFSLQKLISLDLSDNSLSGEIPELVIQ-LQNLEILHL----FSN-----NFTGKIPVALTSL 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   244 TieefRLAYLDYYLDDI-------IDLFNCLT--NVSSFSLVSVTIERVKDFSYNFgwQHLELVNCKFGQFPTL--KLKS 312
Cdd:PLN00113 332 P----RLQVLQLWSNKFsgeipknLGKHNNLTvlDLSTNNLTGEIPEGLCSSGNLF--KLILFSNSLEGEIPKSlgACRS 405

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   313 LKRLTFTSNKGGNAFSE--VDLPSLEFLDLSRNGLSfkGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQ 390
Cdd:PLN00113 406 LRRVRLQDNSFSGELPSefTKLPLVYFLDISNNNLQ--GRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLS 483

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   391 HSNLKQMSEFSvFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENfLPDIFTELRNLTFLDLSQCQLEQ 470
Cdd:PLN00113 484 RNQFSGAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQ-IPASFSEMPVLSQLDLSQNQLSG 561

                        490       500
                 ....*....|....*....|..
gi 4507533   471 LSPTAFNSLSSLQVLNMSHNNF 492
Cdd:PLN00113 562 EIPKNLGNVESLVQVNISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 359-521 5.08e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 5.08e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  359 TSLKYLDLsFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSvflSLRNLIYLDISHTHTRVAFNgiFNGLSSLEVLKM 438
Cdd:cd21340  24 KNLKVLYL-YDNKITKIENLEFLTNLTHLYLQNNQIEKIENLE---NLVNLKKLYLGGNRISVVEG--LENLTNLEELHI 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  439 AGNSFQEN----FLPD-IFTELRNLTFLDLSQCQLEQLSPtaFNSLSSLQVLNMSHNNFFSLD--TFPYKCLNSLQVLDY 511
Cdd:cd21340  98 ENQRLPPGekltFDPRsLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDL 175

                       170
                ....*....|
gi 4507533  512 SLNHIMTSKK 521
Cdd:cd21340 176 TGNPVCKKPK 185
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-158 3.44e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 3.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533    3 LNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPiqslalgAF 82
Cdd:COG4886  37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------EL 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   83 SGLSSLQKLVAVETNLASLENFpIGHLKTLKELNVAHNLIQSfkLPEYFSNLTNLEHLDLSSNKIQSI-----YCTDLRV 157
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLpeelgNLTNLKE 186


                .
gi 4507533  158 L 158
Cdd:COG4886 187 L 187
LRR_8 pfam13855
Leucine rich repeat;
17-74 4.43e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 4.43e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 4507533     17 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPI 74
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 36-150 1.94e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 1.94e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   36 SFPELQVLDLSRCEIQTIEDgaYQSLSHLSTLILTGNPIQSLalGAFSGLSSLQKL------VAVETNLASLENF----- 104
Cdd:cd21340  22 LCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLylggnrISVVEGLENLTNLeelhi 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4507533  105 -----PIGH------------LKTLKELNVAHNLIQSfklPEYFSNLTNLEHLDLSSNKIQSI 150
Cdd:cd21340  98 enqrlPPGEkltfdprslaalSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNQISDL 157
LRRCT smart00082
Leucine rich repeat C-terminal domain;
539-585 6.79e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 6.79e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4507533     539 NDFACTCEHQSFLQWIKDQRQLLvEVERMECATPSDKQGmPVLSLNI 585
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ-DPVDLRCASPSSLRG-PLLELLH 45
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 309-516 7.87e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 7.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   309 KLKSLKRLTFTSNK--GGNAFSEVDLPSLEFLDLSRNGLSfkGCCSQSDFGTTSLKYLDLSFNGVI-TMSSNFLGLEQLE 385
Cdd:PLN00113 186 NLTSLEFLTLASNQlvGQIPRELGQMKSLKWIYLGYNNLS--GEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQ 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   386 HLDFQHSNLKQMSEFSVFlSLRNLIYLDISHthtrvafngifNGLSSLevlkmagnsfqenfLPDIFTELRNLTFLDLSQ 465
Cdd:PLN00113 264 YLFLYQNKLSGPIPPSIF-SLQKLISLDLSD-----------NSLSGE--------------IPELVIQLQNLEILHLFS 317

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 4507533   466 CQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHI 516
Cdd:PLN00113 318 NNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL 368
LRR_8 pfam13855
Leucine rich repeat;
431-492 1.89e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.89e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4507533    431 SSLEVLKMAGNSFQeNFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNF 492
Cdd:pfam13855   1 PNLRSLDLSNNRLT-SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
634-775 3.24e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 127.44  E-value: 3.24e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533     634 YDAFVIYSSQDedWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEI 713
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEI-DEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4507533     714 AQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNtYLEWEDSVLGRhiFWRRLRKAL 775
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN-YLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-776 1.54e-32

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 123.63  E-value: 1.54e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533    637 FVIYSS----QDEDWVRNELVKNLeeGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYE 712
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533    713 IAQTWQfLSSRAGIIFIVLQKVEK-------TLLRQQVELYRLLSRNTYLEWE------------DSVLGRHIFWRRLRK 773
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156


                  ...
gi 4507533    774 ALL 776
Cdd:pfam01582 157 DIS 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
250-541 3.66e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 3.66e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  250 LAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSE 329
Cdd:COG4886  13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  330 VDLPSLEFLDLSRNGLSFKgccsqsdfgTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEfsVFLSLRNL 409
Cdd:COG4886  93 GDLTNLTELDLSGNEELSN---------LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  410 IYLDISHTHTRVAFNGIFNgLSSLEVLKMAGNSFQEnfLPDIFTELRNLTFLDLSQCQLEQLsPTAFNSLSSLQVLNMSH 489
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSN 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4507533  490 NNFFSLDTFpyKCLNSLQVLDYSLNHIMT-SKKQELQhfpsSLAFLNLTQNDF 541
Cdd:COG4886 238 NQLTDLPEL--GNLTNLEELDLSNNQLTDlPPLANLT----NLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 7-492 4.95e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.43  E-value: 4.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533     7 KIPDN---LPFSTKNLDLSFNPLRhlGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFS 83
Cdd:PLN00113 108 PIPDDiftTSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533    84 GLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIqSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPL 163
Cdd:PLN00113 186 NLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQY 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   164 LNLSLDLSLNPmnfIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQgLAGLEVHRLvlgeFRNegnleKFDKSALEGLCNL 243
Cdd:PLN00113 265 LFLYQNKLSGP---IPPSIFSLQKLISLDLSDNSLSGEIPELVIQ-LQNLEILHL----FSN-----NFTGKIPVALTSL 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   244 TieefRLAYLDYYLDDI-------IDLFNCLT--NVSSFSLVSVTIERVKDFSYNFgwQHLELVNCKFGQFPTL--KLKS 312
Cdd:PLN00113 332 P----RLQVLQLWSNKFsgeipknLGKHNNLTvlDLSTNNLTGEIPEGLCSSGNLF--KLILFSNSLEGEIPKSlgACRS 405

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   313 LKRLTFTSNKGGNAFSE--VDLPSLEFLDLSRNGLSfkGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQ 390
Cdd:PLN00113 406 LRRVRLQDNSFSGELPSefTKLPLVYFLDISNNNLQ--GRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLS 483

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   391 HSNLKQMSEFSvFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENfLPDIFTELRNLTFLDLSQCQLEQ 470
Cdd:PLN00113 484 RNQFSGAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQ-IPASFSEMPVLSQLDLSQNQLSG 561

                        490       500
                 ....*....|....*....|..
gi 4507533   471 LSPTAFNSLSSLQVLNMSHNNF 492
Cdd:PLN00113 562 EIPKNLGNVESLVQVNISHNHL 583
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
293-566 7.70e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 7.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  293 QHLELVNCKFGQFPTL--KLKSLKRLTFTSNKGGNAFSEV-DLPSLEFLDLSRNGLSfkgCCSQSDFGTTSLKYLDLSFN 369
Cdd:COG4886 116 ESLDLSGNQLTDLPEElaNLTNLKELDLSNNQLTDLPEPLgNLTNLKSLDLSNNQLT---DLPEELGNLTNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  370 GVITMSSNFLGLEQLEHLDFQHSNLKQMSEfsVFLSLRNLIYLDISHthtrvafNGI-----FNGLSSLEVLKMAGNSFQ 444
Cdd:COG4886 193 QITDLPEPLGNLTNLEELDLSGNQLTDLPE--PLANLTNLETLDLSN-------NQLtdlpeLGNLTNLEELDLSNNQLT 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  445 EnfLPDIFtELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQEL 524
Cdd:COG4886 264 D--LPPLA-NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4507533  525 QHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVER 566
Cdd:COG4886 341 ALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 637-732 4.96e-13

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 66.18  E-value: 4.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533    637 FVIYSSQDEDWVRnELVKNLEE-GVPPFqlcLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAq 715
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAaGYRVW---LDRWDIRPGDDWVEEI-EEAIENSDRVLVVLSPNYLESPWCRAEWEAA- 75

                          90
                  ....*....|....*..
gi 4507533    716 tWQFLSSRAGIIFIVLQ 732
Cdd:pfam13676  76 -LADPEGRKRLIPVRLE 91
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 359-521 5.08e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 5.08e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  359 TSLKYLDLsFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSvflSLRNLIYLDISHTHTRVAFNgiFNGLSSLEVLKM 438
Cdd:cd21340  24 KNLKVLYL-YDNKITKIENLEFLTNLTHLYLQNNQIEKIENLE---NLVNLKKLYLGGNRISVVEG--LENLTNLEELHI 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  439 AGNSFQEN----FLPD-IFTELRNLTFLDLSQCQLEQLSPtaFNSLSSLQVLNMSHNNFFSLD--TFPYKCLNSLQVLDY 511
Cdd:cd21340  98 ENQRLPPGekltFDPRsLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDL 175

                       170
                ....*....|
gi 4507533  512 SLNHIMTSKK 521
Cdd:cd21340 176 TGNPVCKKPK 185
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-463 1.75e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 1.75e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   29 LGSYSFFSFPELQVLDLSRCEiqtiedgAYQSLSHLSTLILTGNPIQSLALgAFSGLSSLQKLVAVETNLASLENfPIGH 108
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGN 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  109 LKTLKELNVAHNLIQSfkLPEYFSNLTNLEHLDLSSNKIQSIyctdlrvlhqmpllnlsldlslnpmnfiqPGAFKEI-R 187
Cdd:COG4886 158 LTNLKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDL-----------------------------PEPLGNLtN 206

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  188 LHKLTLRNNfdslnvmktciqglaglevhrlvlgefrnegNLEKFDKSaLEGLCNLTieefrlayldyylddiidlfncl 267
Cdd:COG4886 207 LEELDLSGN-------------------------------QLTDLPEP-LANLTNLE----------------------- 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  268 tnvssfslvsvtiervkdfsynfgwqHLELVNCKFGQFPTL-KLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLS 346
Cdd:COG4886 232 --------------------------TLDLSNNQLTDLPELgNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  347 FKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGI 426
Cdd:COG4886 286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 4507533  427 FNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDL 463
Cdd:COG4886 366 LLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-158 3.44e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 3.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533    3 LNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPiqslalgAF 82
Cdd:COG4886  37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------EL 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   83 SGLSSLQKLVAVETNLASLENFpIGHLKTLKELNVAHNLIQSfkLPEYFSNLTNLEHLDLSSNKIQSI-----YCTDLRV 157
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLpeelgNLTNLKE 186


                .
gi 4507533  158 L 158
Cdd:COG4886 187 L 187
LRR_8 pfam13855
Leucine rich repeat;
17-74 4.43e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 4.43e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 4507533     17 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPI 74
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
38-91 1.13e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.13e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 4507533     38 PELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKL 91
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL 54
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 36-150 1.94e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 1.94e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   36 SFPELQVLDLSRCEIQTIEDgaYQSLSHLSTLILTGNPIQSLalGAFSGLSSLQKL------VAVETNLASLENF----- 104
Cdd:cd21340  22 LCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLylggnrISVVEGLENLTNLeelhi 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4507533  105 -----PIGH------------LKTLKELNVAHNLIQSfklPEYFSNLTNLEHLDLSSNKIQSI 150
Cdd:cd21340  98 enqrlPPGEkltfdprslaalSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNQISDL 157
LRRCT smart00082
Leucine rich repeat C-terminal domain;
539-585 6.79e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 6.79e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4507533     539 NDFACTCEHQSFLQWIKDQRQLLvEVERMECATPSDKQGmPVLSLNI 585
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ-DPVDLRCASPSSLRG-PLLELLH 45
LRR_8 pfam13855
Leucine rich repeat;
62-147 7.67e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 7.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533     62 SHLSTLILTGNPIQSLALGAFSGLSSLqklvavetnlaslenfpighlktlKELNVAHNLIQSFkLPEYFSNLTNLEHLD 141
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNL------------------------KVLDLSNNLLTTL-SPGAFSGLPSLRYLD 55


                  ....*.
gi 4507533    142 LSSNKI 147
Cdd:pfam13855  56 LSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 381-539 1.45e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  381 LEQLEHLDFQHSNLKQMSEFSVFLSLRNLiYL---DISH----------THTRVAFNGI-----FNGLSSLEVLKMAGNS 442
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVL-YLydnKITKienlefltnlTHLYLQNNQIekienLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  443 FQ--ENflpdiFTELRNLTFLDLSQCQL---EQLS--PTAFNSLS-SLQVLNMSHNNFFSLDtfPYKCLNSLQVLDYSLN 514
Cdd:cd21340  80 ISvvEG-----LENLTNLEELHIENQRLppgEKLTfdPRSLAALSnSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNN 152

                       170       180
                ....*....|....*....|....*..
gi 4507533  515 HI--MTSKKQELQHFPsSLAFLNLTQN 539
Cdd:cd21340 153 QIsdLEELLDLLSSWP-SLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 309-516 7.87e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 7.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   309 KLKSLKRLTFTSNK--GGNAFSEVDLPSLEFLDLSRNGLSfkGCCSQSDFGTTSLKYLDLSFNGVI-TMSSNFLGLEQLE 385
Cdd:PLN00113 186 NLTSLEFLTLASNQlvGQIPRELGQMKSLKWIYLGYNNLS--GEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQ 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   386 HLDFQHSNLKQMSEFSVFlSLRNLIYLDISHthtrvafngifNGLSSLevlkmagnsfqenfLPDIFTELRNLTFLDLSQ 465
Cdd:PLN00113 264 YLFLYQNKLSGPIPPSIF-SLQKLISLDLSD-----------NSLSGE--------------IPELVIQLQNLEILHLFS 317

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 4507533   466 CQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHI 516
Cdd:PLN00113 318 NNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL 368
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 17-587 9.09e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 9.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533    17 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQ-TIEDGAYQSLSHLSTLILTGNPIQ-SLALGAFSGLSSLQklvaV 94
Cdd:PLN00113  72 VSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLD----L 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533    95 ETNLASLENF-PIGHLKTLKELNVAHNLIQSfKLPEYFSNLTNLEHLDLSSNKIqsiyctdlrvLHQMPLlnlsldlsln 173
Cdd:PLN00113 148 SNNMLSGEIPnDIGSFSSLKVLDLGGNVLVG-KIPNSLTNLTSLEFLTLASNQL----------VGQIPR---------- 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   174 pmnfiQPGAFKEIRLHKLTLrNNFDSlnVMKTCIQGLAGLEVHRLVLGefrnegNLEKFDKSALEGLCNLtieEFRLAYL 253
Cdd:PLN00113 207 -----ELGQMKSLKWIYLGY-NNLSG--EIPYEIGGLTSLNHLDLVYN------NLTGPIPSSLGNLKNL---QYLFLYQ 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   254 DYYLDDIIDLFNCLTNVSSFslvsvtiervkDFSYNFgwqhlelvncKFGQFPTL--KLKSLKRLTFTSNK--GGNAFSE 329
Cdd:PLN00113 270 NKLSGPIPPSIFSLQKLISL-----------DLSDNS----------LSGEIPELviQLQNLEILHLFSNNftGKIPVAL 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   330 VDLPSLEFLDLSRNGLSFKgccSQSDFGT-TSLKYLDLSfngvitmsSNFLGLEQLEHLdFQHSNLKQMSEFSVflSLRN 408
Cdd:PLN00113 329 TSLPRLQVLQLWSNKFSGE---IPKNLGKhNNLTVLDLS--------TNNLTGEIPEGL-CSSGNLFKLILFSN--SLEG 394

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   409 LIYLDIShthtrvafngifnGLSSLEVLKMAGNSFQENfLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMS 488
Cdd:PLN00113 395 EIPKSLG-------------ACRSLRRVRLQDNSFSGE-LPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLA 460

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   489 HNNFFS--LDTFPYKclnSLQVLDYSLNHIMTSKKQELQHFPsSLAFLNLTQNDFacTCEHQSFLQWIKDQRQLLVEVER 566
Cdd:PLN00113 461 RNKFFGglPDSFGSK---RLENLDLSRNQFSGAVPRKLGSLS-ELMQLKLSENKL--SGEIPDELSSCKKLVSLDLSHNQ 534

                        570       580
                 ....*....|....*....|..
gi 4507533   567 MECATPSDKQGMPVLS-LNITC 587
Cdd:PLN00113 535 LSGQIPASFSEMPVLSqLDLSQ 556
LRR_8 pfam13855
Leucine rich repeat;
111-162 6.80e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 6.80e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 4507533    111 TLKELNVAHNLIQSFKlPEYFSNLTNLEHLDLSSNKIQSIyctDLRVLHQMP 162
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTL---SPGAFSGLP 49
LRR_9 pfam14580
Leucine-rich repeat;
1-103 1.23e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 43.60  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533      1 MELNFYKIP--DNL-----PFSTknLDLSFNPLRHLGSYSFFsfPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNP 73
Cdd:pfam14580  24 LDLRGYKIPiiENLgatldQFDT--IDFSDNEIRKLDGFPLL--RRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNN 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 4507533     74 IQSlaLGAFSGLSSLQKLvaveTNLASLEN 103
Cdd:pfam14580 100 LQE--LGDLDPLASLKKL----TFLSLLRN 123
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 112-416 1.43e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 1.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  112 LKELNVAHNLIQSFKLPEYFSNLT---NLEHLDLSSNKIQSIyctdLRVLHqmpllnlsldlsLNPMNFIqpgafKEIRL 188
Cdd:cd00116  25 LQVLRLEGNTLGEEAAKALASALRpqpSLKELCLSLNETGRI----PRGLQ------------SLLQGLT-----KGCGL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  189 HKLTLRNNfdSLnvmktCIQGLAGLE--VHRLVLGEFRNEGNLEKFDKSAL--EGLCNLT--IEEFRLAYldyylddiid 262
Cdd:cd00116  84 QELDLSDN--AL-----GPDGCGVLEslLRSSSLQELKLNNNGLGDRGLRLlaKGLKDLPpaLEKLVLGR---------- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  263 lfNCLTNVSSFSLVSVTIE----RVKDFSYN----FGWQHLelvnCK-FGQFPTLKLKSLKRLTFTSnKGGNAFSEV--D 331
Cdd:cd00116 147 --NRLEGASCEALAKALRAnrdlKELNLANNgigdAGIRAL----AEgLKANCNLEVLDLNNNGLTD-EGASALAETlaS 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  332 LPSLEFLDLSRNGLSFKGC---CSQSDFGTTSLKYLDLSFN-----GVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVF 403
Cdd:cd00116 220 LKSLEVLNLGDNNLTDAGAaalASALLSPNISLLTLSLSCNditddGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLA 299

                       330
                ....*....|....*..
gi 4507533  404 LSL----RNLIYLDISH 416
Cdd:cd00116 300 ESLlepgNELESLWVKD 316
LRR_8 pfam13855
Leucine rich repeat;
431-492 1.89e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.89e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4507533    431 SSLEVLKMAGNSFQeNFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNF 492
Cdd:pfam13855   1 PNLRSLDLSNNRLT-SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 40-155 3.71e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 3.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   40 LQVLDLSRCEIQTIEDGAYQSLSHLSTL---ILTGNPIQSLAL-----GAFSGLSSLQKLVAVETNLASLENFPIG---- 107
Cdd:cd00116  83 LQELDLSDNALGPDGCGVLESLLRSSSLqelKLNNNGLGDRGLrllakGLKDLPPALEKLVLGRNRLEGASCEALAkalr 162

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 4507533  108 HLKTLKELNVAHNLIQSF---KLPEYFSNLTNLEHLDLSSNKIQSIYCTDL 155
Cdd:cd00116 163 ANRDLKELNLANNGIGDAgirALAEGLKANCNLEVLDLNNNGLTDEGASAL 213
PLN03150 PLN03150
hypothetical protein; Provisional
 447-543 6.08e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 6.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   447 FLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQH 526
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGG 512

                         90
                 ....*....|....*..
gi 4507533   527 FPSSLAFLNLTQNDFAC 543
Cdd:PLN03150 513 RLLHRASFNFTDNAGLC 529
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 332-541 6.75e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 6.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  332 LPSLEFLDLSRNGLSFKGCCSQSDF-GTTSLKYLDLSFNGvitmssnflgleqlehLDFQHSNLKQMSEFSVFLSLRNLI 410
Cdd:cd00116  80 GCGLQELDLSDNALGPDGCGVLESLlRSSSLQELKLNNNG----------------LGDRGLRLLAKGLKDLPPALEKLV 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  411 --YLDISHTHTRvAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELR---NLTFLDLSQCQLE-----QLSPTaFNSLS 480
Cdd:cd00116 144 lgRNRLEGASCE-ALAKALRANRDLKELNLANNGIGDAGIRALAEGLKancNLEVLDLNNNGLTdegasALAET-LASLK 221

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533  481 SLQVLNMSHNNFFS-----LDTFPYKCLNSLQVLDYSLNHIMT----SKKQELQHFPsSLAFLNLTQNDF 541
Cdd:cd00116 222 SLEVLNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDITDdgakDLAEVLAEKE-SLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
359-418 8.10e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 8.10e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507533    359 TSLKYLDLSFNGVITMS-SNFLGLEQLEHLDFQHSNLKQMSEfSVFLSLRNLIYLDISHTH 418
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 15-147 2.93e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 2.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   15 STKNLDLSFNPLRHLGSYSFFS----FPELQVLDLSRCEIQtiEDG------AYQSLSHLSTLILTGNPIQSlalgafSG 84
Cdd:COG5238 209 TVTTLWLKRNPIGDEGAEILAEalkgNKSLTTLDLSNNQIG--DEGvialaeALKNNTTVETLYLSGNQIGA------EG 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   85 LSSLQKLVAVETNLASL---ENfPIG------------HLKTLKELNVAHNLI--QSFK-LPEYFSNLTNLEHLDLSSNK 146
Cdd:COG5238 281 AIALAKALQGNTTLTSLdlsVN-RIGdegaialaeglqGNKTLHTLNLAYNGIgaQGAIaLAKALQENTTLHSLDLSDNQ 359


                .
gi 4507533  147 I 147
Cdd:COG5238 360 I 360
LRR_8 pfam13855
Leucine rich repeat;
480-541 4.68e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4507533    480 SSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPsSLAFLNLTQNDF 541
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 428-539 5.90e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 5.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507533   428 NGLSSLEVLKMAGNSFQENFLPDIFtELRNLTFLDLSQCQLE-QLSPTAFNSLSSLQVLNMSHNNFFSldTFPYKCLNSL 506
Cdd:PLN00113  66 NNSSRVVSIDLSGKNISGKISSAIF-RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG--SIPRGSIPNL 142

                         90       100       110
                 ....*....|....*....|....*....|...
gi 4507533   507 QVLDYSLNHIMTSKKQELQHFpSSLAFLNLTQN 539
Cdd:PLN00113 143 ETLDLSNNMLSGEIPNDIGSF-SSLKVLDLGGN 174
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 457-494 5.98e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 5.98e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4507533    457 NLTFLDLSQCQLEQLSPtaFNSLSSLQVLNMSHNNFFS 494
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKIT 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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