NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|29540545|ref|NP_003158|]
View 

sulfotransferase 2A1 [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-278 2.15e-103

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 301.57  E-value: 2.15e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545    34 DEDVIILTYPKSGTNWLAEILCLMHSKGDAKWIQSVPI---WERSPWVE---------SEIGYTALSETESPRLFSSHLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545   102 IQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFLL 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545   182 LSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSvdyvVDKAQLLRKGVSGDWKNHFTVA 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP----KEVSPFFRKGLVGDWKNYFTPE 236

                         250
                  ....*....|....*..
gi 29540545   262 QAEDFDKLFQEKMADLP 278
Cdd:pfam00685 237 QAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-278 2.15e-103

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 301.57  E-value: 2.15e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545    34 DEDVIILTYPKSGTNWLAEILCLMHSKGDAKWIQSVPI---WERSPWVE---------SEIGYTALSETESPRLFSSHLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545   102 IQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFLL 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545   182 LSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSvdyvVDKAQLLRKGVSGDWKNHFTVA 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP----KEVSPFFRKGLVGDWKNYFTPE 236

                         250
                  ....*....|....*..
gi 29540545   262 QAEDFDKLFQEKMADLP 278
Cdd:pfam00685 237 QAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 21-276 3.70e-28

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 110.78  E-value: 3.70e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545   21 ETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLM--HSKGDakwIQSVPIWERSP-----WVESEIGY---TALSET 90
Cdd:PLN02164  66 EGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIanRSRFD---DSSNPLLKRNPhefvpYIEIDFPFfpsVDVLKD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545   91 ESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKP-KSWEEYFEWFCQGTVLYGSWFDHIHG 169
Cdd:PLN02164 143 KGNTLFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLG 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545  170 -WMPMREEKN-FLLLSYEELKQDTGRTIEKICQFLGK--TLEPEELNL---ILKNSSFQSMKENKMSNYSLLSVDY--VV 240
Cdd:PLN02164 223 yWKAYQENPDrILFLKYETMRADPLPYVKRLAEFMGYgfTAEEEEKGVvekVVKLCSFETLKNLEANKGEKDREDRpaVY 302

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 29540545  241 DKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMAD 276
Cdd:PLN02164 303 ANSAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKG 338
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
38-231 1.24e-04

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 42.31  E-value: 1.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545  38 IILTYPKSGTNWLAEIL-------C---LMHSKGDAKWIQSVPIWERSPWVESEIGYtALSETESP------RLFSSHLP 101
Cdd:COG4424  10 VICATPRSGSTLLCELLnatgvagCpgeYFNPPFIPEWARGFLLGDRDRDPDEYLRA-IRRAGTTPngvfgfKLFWDQLP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545 102 ---------IQLFPKsffsskAKVIYLMRnpRDVL---VSgyfFWKnmkfIKKPKSW---------------------EE 148
Cdd:COG4424  89 rllqralrlLAAFPD------LKFIHLTR--RDKLaqaVS---LVI----AQQTGQWhsdaddalaptappeydaeeiAR 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545 149 YFEWFCQGTVLYGSWFDhIHGWMPMReeknfllLSYEELKQDTGRTIEKICQFLGKTLEPEELNLIL-KNSSFQSmkENK 227
Cdd:COG4424 154 LLEALQDFEARWEAWFA-RTGITPLE-------ITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALkKQADEPS--DEW 223


                ....
gi 29540545 228 MSNY 231
Cdd:COG4424 224 VARF 227
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-278 2.15e-103

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 301.57  E-value: 2.15e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545    34 DEDVIILTYPKSGTNWLAEILCLMHSKGDAKWIQSVPI---WERSPWVE---------SEIGYTALSETESPRLFSSHLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545   102 IQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFLL 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545   182 LSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSvdyvVDKAQLLRKGVSGDWKNHFTVA 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP----KEVSPFFRKGLVGDWKNYFTPE 236

                         250
                  ....*....|....*..
gi 29540545   262 QAEDFDKLFQEKMADLP 278
Cdd:pfam00685 237 QAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 21-276 3.70e-28

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 110.78  E-value: 3.70e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545   21 ETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLM--HSKGDakwIQSVPIWERSP-----WVESEIGY---TALSET 90
Cdd:PLN02164  66 EGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIanRSRFD---DSSNPLLKRNPhefvpYIEIDFPFfpsVDVLKD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545   91 ESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKP-KSWEEYFEWFCQGTVLYGSWFDHIHG 169
Cdd:PLN02164 143 KGNTLFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLG 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545  170 -WMPMREEKN-FLLLSYEELKQDTGRTIEKICQFLGK--TLEPEELNL---ILKNSSFQSMKENKMSNYSLLSVDY--VV 240
Cdd:PLN02164 223 yWKAYQENPDrILFLKYETMRADPLPYVKRLAEFMGYgfTAEEEEKGVvekVVKLCSFETLKNLEANKGEKDREDRpaVY 302

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 29540545  241 DKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMAD 276
Cdd:PLN02164 303 ANSAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKG 338
Sulfotransfer_3 pfam13469
Sulfotransferase family;
37-208 5.69e-13

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 65.39  E-value: 5.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545    37 VIILTYPKSGTNWLAEILCLmHSKGDAK--WIQSVPIW--ERSPWVESeigYTALSETESPR----------LFSSHLPI 102
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAA-HPDVRPPeeTWFVIPRIlaLLQAWGKS---LEALARVPSYArwlcdkspshLFHLDLLL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545   103 QLFPKsffsskAKVIYLMRNPRDVLVSGYffwKNMkFIKKPKSWEEYFEWFCQGTVLYgsWFDHIHGWMPMREE---KNF 179
Cdd:pfam13469  77 KAFPD------AKFIHLHRDPVDTVISSY---CSL-FGFTLSSYSTAFLRDIGLALAR--WSRAYERLMAARARvppGRF 144

                         170       180
                  ....*....|....*....|....*....
gi 29540545   180 LLLSYEELKQDTGRTIEKICQFLGKTLEP 208
Cdd:pfam13469 145 LDVRYEDLVADPEGTLRRILEFLGLPWDD 173
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
38-231 1.24e-04

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 42.31  E-value: 1.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545  38 IILTYPKSGTNWLAEIL-------C---LMHSKGDAKWIQSVPIWERSPWVESEIGYtALSETESP------RLFSSHLP 101
Cdd:COG4424  10 VICATPRSGSTLLCELLnatgvagCpgeYFNPPFIPEWARGFLLGDRDRDPDEYLRA-IRRAGTTPngvfgfKLFWDQLP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545 102 ---------IQLFPKsffsskAKVIYLMRnpRDVL---VSgyfFWKnmkfIKKPKSW---------------------EE 148
Cdd:COG4424  89 rllqralrlLAAFPD------LKFIHLTR--RDKLaqaVS---LVI----AQQTGQWhsdaddalaptappeydaeeiAR 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29540545 149 YFEWFCQGTVLYGSWFDhIHGWMPMReeknfllLSYEELKQDTGRTIEKICQFLGKTLEPEELNLIL-KNSSFQSmkENK 227
Cdd:COG4424 154 LLEALQDFEARWEAWFA-RTGITPLE-------ITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALkKQADEPS--DEW 223


                ....
gi 29540545 228 MSNY 231
Cdd:COG4424 224 VARF 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH