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Conserved domains on  [gi|4507217|ref|NP_003124|]
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signal recognition particle 9 kDa protein isoform 2 [Homo sapiens]

Protein Classification

SRP9/SRP21 family protein( domain architecture ID 10527478)

SRP9/SRP21 family protein is a component of the signal-recognition-particle (SRP), whose assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP9-21 pfam05486
Signal recognition particle 9 kDa protein (SRP9); This family consists of several eukaryotic ...
 4-73 7.73e-18

Signal recognition particle 9 kDa protein (SRP9); This family consists of several eukaryotic SRP9 proteins. SRP9 together with the Alu-homologous region of 7SL RNA and SRP14 comprise the "Alu domain" of SRP, which mediates pausing of synthesis of ribosome associated nascent polypeptides that have been engaged by the targeting domain of SRP. This family also contains the homologous fungal SRP21.


:

Pssm-ID: 428490  Cd Length: 83  Bit Score: 70.70  E-value: 7.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507217     4 YQTWEEFSRAAEKLYLADPMKARVVLKYRHS-----------DGNLCVKVTDD--LVCLVYKTDQAQDVKKIEKFHSQLM 70
Cdd:pfam05486  1 VKTSDEFIEQSELLLEANPSTTRITIKYRHPskkkskkktkpRGTLTLKTYDPvsGVCLKYKTNKAAEVSRLLSALGPLG 80


                 ...
gi 4507217    71 RLM 73
Cdd:pfam05486 81 RSM 83
 
Name Accession Description Interval E-value
SRP9-21 pfam05486
Signal recognition particle 9 kDa protein (SRP9); This family consists of several eukaryotic ...
 4-73 7.73e-18

Signal recognition particle 9 kDa protein (SRP9); This family consists of several eukaryotic SRP9 proteins. SRP9 together with the Alu-homologous region of 7SL RNA and SRP14 comprise the "Alu domain" of SRP, which mediates pausing of synthesis of ribosome associated nascent polypeptides that have been engaged by the targeting domain of SRP. This family also contains the homologous fungal SRP21.


Pssm-ID: 428490  Cd Length: 83  Bit Score: 70.70  E-value: 7.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507217     4 YQTWEEFSRAAEKLYLADPMKARVVLKYRHS-----------DGNLCVKVTDD--LVCLVYKTDQAQDVKKIEKFHSQLM 70
Cdd:pfam05486  1 VKTSDEFIEQSELLLEANPSTTRITIKYRHPskkkskkktkpRGTLTLKTYDPvsGVCLKYKTNKAAEVSRLLSALGPLG 80


                 ...
gi 4507217    71 RLM 73
Cdd:pfam05486 81 RSM 83
 
Name Accession Description Interval E-value
SRP9-21 pfam05486
Signal recognition particle 9 kDa protein (SRP9); This family consists of several eukaryotic ...
 4-73 7.73e-18

Signal recognition particle 9 kDa protein (SRP9); This family consists of several eukaryotic SRP9 proteins. SRP9 together with the Alu-homologous region of 7SL RNA and SRP14 comprise the "Alu domain" of SRP, which mediates pausing of synthesis of ribosome associated nascent polypeptides that have been engaged by the targeting domain of SRP. This family also contains the homologous fungal SRP21.


Pssm-ID: 428490  Cd Length: 83  Bit Score: 70.70  E-value: 7.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507217     4 YQTWEEFSRAAEKLYLADPMKARVVLKYRHS-----------DGNLCVKVTDD--LVCLVYKTDQAQDVKKIEKFHSQLM 70
Cdd:pfam05486  1 VKTSDEFIEQSELLLEANPSTTRITIKYRHPskkkskkktkpRGTLTLKTYDPvsGVCLKYKTNKAAEVSRLLSALGPLG 80


                 ...
gi 4507217    71 RLM 73
Cdd:pfam05486 81 RSM 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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