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Conserved domains on  [gi|27545326|ref|NP_003064|]
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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNF5 pfam04855
SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ...
 181-363 3.09e-66

SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterized so far. This family consists of the conserved region of SNF5, including a direct repeat motif. SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF complex. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs).


:

Pssm-ID: 428158  Cd Length: 186  Bit Score: 208.20  E-value: 3.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545326   181 SQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPL---TFVPAIASAIRQQIESY--------- 248
Cdd:pfam04855   1 ELPETLVPIRIDLDIDKYRLRDTFTWNLHETLITPEQFAQTLCEDLDLPNEpapAFADQIAKQIREQLEEYagvalhplp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545326   249 ------------PTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIR 316
Cdd:pfam04855  81 yphveeeddpldPDLPYLNPDDDLRILIKLDITIGNHLLTDQFEWDLLSPLNTPEEFAKQTCADLGLSGEFVTAIAHAIR 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 27545326   317 GQLSWHQKtYAFSenplptveiairntgdadqwcPLLETLTDAEMEK 363
Cdd:pfam04855 161 EQVLRYKK-SLCT---------------------PKLEELSEEELEK 185
WH_NTD_SMARCB1 cd21086
N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated ...
 9-107 8.78e-53

N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) and similar proteins; SMARCB1, also termed BRG1-associated factor 47 (BAF47), or integrase interactor 1 protein (INI1), or SNF5, or SNF5L1, is a core component of the BAF (hSWI/SNF) complex, an ATP-dependent chromatin-remodeling complex that plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The model corresponds to the N-terminal winged helix DNA binding domain of SMARCB1, which is structurally related to the SKI/SNO/DAC domain that is found in a number of metazoan chromatin-associated proteins.


:

Pssm-ID: 411036  Cd Length: 88  Bit Score: 170.10  E-value: 8.78e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545326   9 TFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEERKKIVAsshgkktkpntKDHGYTTLATSV 88
Cdd:cd21086   1 TYGEKPRSFQLEEDGERYMIGSEVGNYLRLFRGSLYKKYPGLWRRQATSEERKKLVE-----------LGLSQHSLATNV 69

                        90
                ....*....|....*....
gi 27545326  89 TLLKASEVEEILDGNDEKY 107
Cdd:cd21086  70 TLLKASEVEEILAGNDEKY 88
 
Name Accession Description Interval E-value
SNF5 pfam04855
SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ...
 181-363 3.09e-66

SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterized so far. This family consists of the conserved region of SNF5, including a direct repeat motif. SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF complex. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs).


Pssm-ID: 428158  Cd Length: 186  Bit Score: 208.20  E-value: 3.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545326   181 SQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPL---TFVPAIASAIRQQIESY--------- 248
Cdd:pfam04855   1 ELPETLVPIRIDLDIDKYRLRDTFTWNLHETLITPEQFAQTLCEDLDLPNEpapAFADQIAKQIREQLEEYagvalhplp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545326   249 ------------PTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIR 316
Cdd:pfam04855  81 yphveeeddpldPDLPYLNPDDDLRILIKLDITIGNHLLTDQFEWDLLSPLNTPEEFAKQTCADLGLSGEFVTAIAHAIR 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 27545326   317 GQLSWHQKtYAFSenplptveiairntgdadqwcPLLETLTDAEMEK 363
Cdd:pfam04855 161 EQVLRYKK-SLCT---------------------PKLEELSEEELEK 185
WH_NTD_SMARCB1 cd21086
N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated ...
 9-107 8.78e-53

N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) and similar proteins; SMARCB1, also termed BRG1-associated factor 47 (BAF47), or integrase interactor 1 protein (INI1), or SNF5, or SNF5L1, is a core component of the BAF (hSWI/SNF) complex, an ATP-dependent chromatin-remodeling complex that plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The model corresponds to the N-terminal winged helix DNA binding domain of SMARCB1, which is structurally related to the SKI/SNO/DAC domain that is found in a number of metazoan chromatin-associated proteins.


Pssm-ID: 411036  Cd Length: 88  Bit Score: 170.10  E-value: 8.78e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545326   9 TFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEERKKIVAsshgkktkpntKDHGYTTLATSV 88
Cdd:cd21086   1 TYGEKPRSFQLEEDGERYMIGSEVGNYLRLFRGSLYKKYPGLWRRQATSEERKKLVE-----------LGLSQHSLATNV 69

                        90
                ....*....|....*....
gi 27545326  89 TLLKASEVEEILDGNDEKY 107
Cdd:cd21086  70 TLLKASEVEEILAGNDEKY 88
 
Name Accession Description Interval E-value
SNF5 pfam04855
SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ...
 181-363 3.09e-66

SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterized so far. This family consists of the conserved region of SNF5, including a direct repeat motif. SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF complex. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs).


Pssm-ID: 428158  Cd Length: 186  Bit Score: 208.20  E-value: 3.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545326   181 SQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPL---TFVPAIASAIRQQIESY--------- 248
Cdd:pfam04855   1 ELPETLVPIRIDLDIDKYRLRDTFTWNLHETLITPEQFAQTLCEDLDLPNEpapAFADQIAKQIREQLEEYagvalhplp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545326   249 ------------PTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIR 316
Cdd:pfam04855  81 yphveeeddpldPDLPYLNPDDDLRILIKLDITIGNHLLTDQFEWDLLSPLNTPEEFAKQTCADLGLSGEFVTAIAHAIR 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 27545326   317 GQLSWHQKtYAFSenplptveiairntgdadqwcPLLETLTDAEMEK 363
Cdd:pfam04855 161 EQVLRYKK-SLCT---------------------PKLEELSEEELEK 185
WH_NTD_SMARCB1 cd21086
N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated ...
 9-107 8.78e-53

N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) and similar proteins; SMARCB1, also termed BRG1-associated factor 47 (BAF47), or integrase interactor 1 protein (INI1), or SNF5, or SNF5L1, is a core component of the BAF (hSWI/SNF) complex, an ATP-dependent chromatin-remodeling complex that plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The model corresponds to the N-terminal winged helix DNA binding domain of SMARCB1, which is structurally related to the SKI/SNO/DAC domain that is found in a number of metazoan chromatin-associated proteins.


Pssm-ID: 411036  Cd Length: 88  Bit Score: 170.10  E-value: 8.78e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545326   9 TFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEERKKIVAsshgkktkpntKDHGYTTLATSV 88
Cdd:cd21086   1 TYGEKPRSFQLEEDGERYMIGSEVGNYLRLFRGSLYKKYPGLWRRQATSEERKKLVE-----------LGLSQHSLATNV 69

                        90
                ....*....|....*....
gi 27545326  89 TLLKASEVEEILDGNDEKY 107
Cdd:cd21086  70 TLLKASEVEEILAGNDEKY 88
WH_NTD_SMARCB1_like cd21055
N-terminal winged helix DNA-binding domain found in SMARCB1, PHF10 and similar proteins; The ...
 13-102 2.64e-31

N-terminal winged helix DNA-binding domain found in SMARCB1, PHF10 and similar proteins; The family includes SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) and PHD finger protein 10 (PHF10), both of which have an N-terminal winged helix DNA-binding domain that is structurally related to the SKI/SNO/DAC domain found in a number of metazoan chromatin-associated proteins. SMARCB1, also termed BRG1-associated factor 47 (BAF47), or integrase interactor 1 protein (INI1), or SNF5, or SNF5L1, is a core component of the BAF (hSWI/SNF) complex, an ATP-dependent chromatin-remodeling complex that plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. PHF10, also termed BRG1-associated factor 45a (BAF45a), or XAP135, is involved in transcription activity regulation by chromatin remodeling. It is a component of the neural progenitors-specific chromatin remodeling complex (npBAF complex) and plays a role in the proliferation of neural progenitors.


Pssm-ID: 411034  Cd Length: 80  Bit Score: 113.76  E-value: 2.64e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545326  13 KPVKFQLED-DGEFYMIGSEVGNYLRMfRGSLYKRYPSLWRRLATVEERKKIVASSHgkktkpntkdHGYTTLATSVTLL 91
Cdd:cd21055   1 KPFEYQWPPkSGEYYMLQSQVGEYLGV-RGSLYRKYPDLWRRQATAEERKYLKELGL----------VTETQLALGLTAL 69

                        90
                ....*....|.
gi 27545326  92 KASEVEEILDG 102
Cdd:cd21055  70 KASEVEDLMAG 80
WH_NTD_PHF10 cd21085
N-terminal winged helix DNA-binding domain found in PHD finger protein 10 (PHF10) and similar ...
 19-108 3.32e-04

N-terminal winged helix DNA-binding domain found in PHD finger protein 10 (PHF10) and similar proteins; PHF10, also termed BRG1-associated factor 45a (BAF45a), or XAP135, is involved in transcription activity regulation by chromatin remodeling. It is a component of the neural progenitors-specific chromatin remodeling complex (npBAF complex) and plays a role in the proliferation of neural progenitors. The model corresponds to the N-terminal winged helix DNA-binding domain of PHF10, which is structurally related to the SKI/SNO/DAC domain that is found in a number of metazoan chromatin-associated proteins.


Pssm-ID: 411035  Cd Length: 89  Bit Score: 39.09  E-value: 3.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545326  19 LEDDGEFYMIGSEVGNYLRMfrGSLYKRYPSLWRRLATVEERKKIVASshgKKTKPNTKDHGyttlatsVTLLKASEVEE 98
Cdd:cd21085   9 PDKSGEYYMLQEQVSEFLGV--KSFKRKYPDLERRPVEAEEREYLREK---GVVTETQCDLG-------LTALRSDEVLD 76

                        90
                ....*....|.
gi 27545326  99 IL-DGNDEKYK 108
Cdd:cd21085  77 LMaKDYPDKYE 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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