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Conserved domains on  [gi|4506987|ref|NP_003044|]
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chromaffin granule amine transporter isoform a [Homo sapiens]

Protein Classification

amine MFS transporter( domain architecture ID 13024382)

amine major facilitator superfamily (MFS) transporter belonging to the solute carrier family 18 facilitates the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 131-479 0e+00

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 584.54  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  131 FLEEEItRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVA 210
Cdd:cd17384  26 YLNENV-RVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVA 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  211 GLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKG 290
Cdd:cd17384 105 GMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEG 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  291 TPLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSL 370
Cdd:cd17384 185 TPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSL 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  371 IGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGA 450
Cdd:cd17384 265 LGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVDSSMMPLLAYLVDLRHSSVYGSVYAIADVAFCLAFALGPSLGGA 344

                       330       340
                ....*....|....*....|....*....
gi 4506987  451 IVKAIGFPWLMVITGVINIVYAPLCYYLR 479
Cdd:cd17384 345 IVKSIGFPWLMRIIGIINILYAPLLFFLR 373
 
Name Accession Description Interval E-value
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 131-479 0e+00

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 584.54  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  131 FLEEEItRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVA 210
Cdd:cd17384  26 YLNENV-RVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVA 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  211 GLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKG 290
Cdd:cd17384 105 GMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEG 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  291 TPLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSL 370
Cdd:cd17384 185 TPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSL 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  371 IGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGA 450
Cdd:cd17384 265 LGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVDSSMMPLLAYLVDLRHSSVYGSVYAIADVAFCLAFALGPSLGGA 344

                       330       340
                ....*....|....*....|....*....
gi 4506987  451 IVKAIGFPWLMVITGVINIVYAPLCYYLR 479
Cdd:cd17384 345 IVKSIGFPWLMRIIGIINILYAPLLFFLR 373
2_A_01_02 TIGR00880
Multidrug resistance protein;
140-281 1.73e-29

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 112.74  E-value: 1.73e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987    140 GVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVY 219
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4506987    220 TdDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPS 281
Cdd:TIGR00880  81 P-PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
139-433 3.85e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 109.29  E-value: 3.85e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  139 VGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASV 218
Cdd:COG2814  47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  219 YTDdHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLK 298
Cdd:COG2814 127 VPP-ERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLR 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  299 DPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGT 378
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4506987  379 SLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIA 433
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
MFS_1 pfam07690
Major Facilitator Superfamily;
139-445 4.70e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 88.63  E-value: 4.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987    139 VGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASV 218
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987    219 YTdDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLdGALQLCILQPSKVSPESAK--------G 290
Cdd:pfam07690 114 FP-PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL-AAVLLLLPRPPPESKRPKPaeearlslI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987    291 TPLFMLLKDPYILVAAGSICFAnMGVAILEPTLPIWmMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSL 370
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFG-FAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4506987    371 IGMLVVGTSLLCVPLAHNIFGLIGPNAGL---GLAIGMVDSSMMPIMGHLVDLRHTsvyGSVYAIADVAFCMGFAIGP 445
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALlllGFGFGLVFPALNALVSDLAPKEER---GTASGLYNTAGSLGGALGP 344
emrD PRK11652
multidrug transporter EmrD;
156-203 4.57e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 39.51  E-value: 4.57e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 4506987   156 FVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIG 203
Cdd:PRK11652  62 FYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109
 
Name Accession Description Interval E-value
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 131-479 0e+00

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 584.54  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  131 FLEEEItRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVA 210
Cdd:cd17384  26 YLNENV-RVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVA 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  211 GLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKG 290
Cdd:cd17384 105 GMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEG 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  291 TPLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSL 370
Cdd:cd17384 185 TPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSL 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  371 IGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGA 450
Cdd:cd17384 265 LGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVDSSMMPLLAYLVDLRHSSVYGSVYAIADVAFCLAFALGPSLGGA 344

                       330       340
                ....*....|....*....|....*....
gi 4506987  451 IVKAIGFPWLMVITGVINIVYAPLCYYLR 479
Cdd:cd17384 345 IVKSIGFPWLMRIIGIINILYAPLLFFLR 373
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
 131-479 1.56e-114

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 343.91  E-value: 1.56e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  131 FLEEEItRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVA 210
Cdd:cd17383  25 YLNEDI-AIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTA 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  211 GLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQP----SKVSPE 286
Cdd:cd17383 104 GLAMIADRFTEEAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLLVMKPvrreTRANMP 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  287 SAKGTPLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGR- 365
Cdd:cd17383 184 EPVGTPIHRLLMDPYIAVCAGALTMANVSLAFLEPTIANWMKDTMNASEWQMGLVWLPAFFPHVLGVYLTVKLAAKYPHy 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  366 -WLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIG 444
Cdd:cd17383 264 qWLMAAVGLAIEGASCFIVPFCTNFGVLIIPLCGICFGIALVDTALLPTLGFLVDVRHVSVYGSVYAIADISYSLAYALG 343

                       330       340       350
                ....*....|....*....|....*....|....*
gi 4506987  445 PSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLR 479
Cdd:cd17383 344 PIVAGQIVHSIGFTQLNIGIGLANLLYAPVLLLLR 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 137-479 1.29e-63

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 212.05  E-value: 1.29e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  137 TRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLA 216
Cdd:cd17325  31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIA 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  217 SVYTDDhERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESA------KG 290
Cdd:cd17325 111 DIAPPE-ERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRavsaarLR 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  291 TPLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSL 370
Cdd:cd17325 190 SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  371 IGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHtsvYGSVYAIADVAFCMGFAIGPSTGGA 450
Cdd:cd17325 270 IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG---RGTAMGLFNTAFSLGMVLGPLLGGF 346

                       330       340
                ....*....|....*....|....*....
gi 4506987  451 IVKAIGFPWLMVITGVINIVYAPLCYYLR 479
Cdd:cd17325 347 LYDAFGFATPFLAAAALLLLAAVLFLLLR 375
2_A_01_02 TIGR00880
Multidrug resistance protein;
140-281 1.73e-29

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 112.74  E-value: 1.73e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987    140 GVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVY 219
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4506987    220 TdDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPS 281
Cdd:TIGR00880  81 P-PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
139-433 3.85e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 109.29  E-value: 3.85e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  139 VGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASV 218
Cdd:COG2814  47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  219 YTDdHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLK 298
Cdd:COG2814 127 VPP-ERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLR 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  299 DPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGT 378
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4506987  379 SLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIA 433
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 137-470 4.05e-19

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 89.20  E-value: 4.05e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  137 TRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAF-----SGT--YTLLFVARTLQGIGSSFSSV 209
Cdd:cd17385  34 TIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFldrvpDGTvfIALCFLVRIVEAVGFAAFIT 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  210 AGLGMLASVYTDdhERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILqPSKVSPESAK 289
Cdd:cd17385 114 ASFAIIAKEFPN--NIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFIL-PRYDDDPSPK 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  290 GTPLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPkWQLGLAFLPASVSYLIGTNLFGVLANKMG-RWLC 368
Cdd:cd17385 191 SGSMLKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHLRQFKLSP-GQVGLMFLILAGSYAISAPLWGWLSDKKKiPKWL 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  369 SLIGMLVVGTSLLCV---PLAH-------NIFGLIGpnagLGLAIGMvdsSMMPIMGHLVDLRHT-------SVYGSVYA 431
Cdd:cd17385 270 MVIGSIITGVGFLLLgpaPLLPikselwmVIIGLVL----LGLSLGA---ALVPTFPELLNCAREygfpdnlSTYGLVSG 342

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 4506987  432 IADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIV 470
Cdd:cd17385 343 LFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFV 381
MFS_1 pfam07690
Major Facilitator Superfamily;
139-445 4.70e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 88.63  E-value: 4.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987    139 VGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASV 218
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987    219 YTdDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLdGALQLCILQPSKVSPESAK--------G 290
Cdd:pfam07690 114 FP-PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL-AAVLLLLPRPPPESKRPKPaeearlslI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987    291 TPLFMLLKDPYILVAAGSICFAnMGVAILEPTLPIWmMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSL 370
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFG-FAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4506987    371 IGMLVVGTSLLCVPLAHNIFGLIGPNAGL---GLAIGMVDSSMMPIMGHLVDLRHTsvyGSVYAIADVAFCMGFAIGP 445
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALlllGFGFGLVFPALNALVSDLAPKEER---GTASGLYNTAGSLGGALGP 344
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 139-479 1.25e-18

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 87.65  E-value: 1.25e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  139 VGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASV 218
Cdd:cd17489  33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADI 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  219 YTDDHeRGRAMGTALGGLALGLLVGAPFGSVMYEFVGksAPFLILAFLALLDGALQLCIL---QPSKVSPESAKGTPLFM 295
Cdd:cd17489 113 IPPSR-RGEGIGYYGLATTLAMALGPALGLFLYQHLG--FAVLFIVAAVLALLALLLVFLvkdPPPVAAEEAEAGTRAFR 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  296 LLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTmcsPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLV 375
Cdd:cd17489 190 RLVEKKVLPPALILFLASIAYGAISTFLPLYAAER---GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLL 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  376 VGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMghlVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAI 455
Cdd:cd17489 267 LALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALA---VDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF 343

                       330       340
                ....*....|....*....|....
gi 4506987  456 GFPWLMVITGVINIVYAPLCYYLR 479
Cdd:cd17489 344 GYRAMFLLAAVVVLLALVLYIFLL 367
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 137-476 1.04e-16

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 81.70  E-value: 1.04e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  137 TRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLA 216
Cdd:cd06174  31 SQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIA 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  217 SVyTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKS----------APFLILAFLALLDGALQLCILQPSKVSPE 286
Cdd:cd06174 111 DL-FPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwravfliaaaLALLAAILLLLVVPDPPESARAKNEEASS 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  287 SAKGTPLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANK-MGR 365
Cdd:cd06174 190 KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGR 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  366 WLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTsvyGSVYAIADVAFCMGFAIGP 445
Cdd:cd06174 270 KPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIR---GTAFGLLNTFGFLGGAIGP 346

                       330       340       350
                ....*....|....*....|....*....|..
gi 4506987  446 STGGAI-VKAIGFPWLMVITGVINIVYAPLCY 476
Cdd:cd06174 347 LLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
137-484 2.64e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 80.30  E-value: 2.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  137 TRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLA 216
Cdd:COG2271  45 AQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIA 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  217 SvYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILaflalldGALQLcilqpskvspesakgtpLFML 296
Cdd:COG2271 125 E-WFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL-------GLPGL-----------------LLAL 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  297 LKdpyILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGR--WLCSLIGML 374
Cdd:COG2271 180 LR---FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLL 256

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  375 VVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTsvyGSVYAIADVAFCMGFAIGPSTGGAIVKA 454
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKAR---GTASGLVNTFGFLGGALGPLLVGYLLDA 333

                       330       340       350
                ....*....|....*....|....*....|
gi 4506987  455 IGFPWLMVITGVINIVYAPLCYYLRSPPAK 484
Cdd:COG2271 334 TGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_1 pfam07690
Major Facilitator Superfamily;
308-489 1.66e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 77.84  E-value: 1.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987    308 SICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAH 387
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987    388 NIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHtsvYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVI 467
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEE---RGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180
                  ....*....|....*....|..
gi 4506987    468 NIVYAPLCYYLRSPPAKEEKLA 489
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKP 182
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 136-467 8.38e-15

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 76.05  E-value: 8.38e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  136 ITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSS-FSSVAGLgm 214
Cdd:cd17324  33 VAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGgFWAIAAA-- 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  215 LASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCIL--QPSKVSPESAKGTP 292
Cdd:cd17324 111 YAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLpsLPPKKPGSLGLLSS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  293 LFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIG 372
Cdd:cd17324 191 LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIAL 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  373 MLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDlRHTSVYGSVYAiadVAFCMGFAIGPSTGGAIV 452
Cdd:cd17324 271 LLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYL---AAYNLGGALGAALGGLVL 346

                       330
                ....*....|....*
gi 4506987  453 KAIGFPWLMVITGVI 467
Cdd:cd17324 347 DHGGWAGVGWVGAAL 361
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
139-457 1.64e-14

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 75.71  E-value: 1.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  139 VGVLFASKAVMQLLVNPFVGPLT----NRIGYHIP-MFAGFVIMFLSTVMFAFS------GTYTLLFVARTLQGIGSSFS 207
Cdd:COG2211  48 VGLILLVARLWDAITDPLIGALSdrtrTRWGRRRPwILIGAIPLALSFVLLFTApdlsptGKLIYALVTYLLLGLAYTLV 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  208 SVAGLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCIL-----QPSK 282
Cdd:COG2211 128 NIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLltffgTKER 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  283 VSPESAKGTP---LFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVL 359
Cdd:COG2211 208 PVPEEEKVSLkesLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRL 287

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  360 ANKMGRWLCSLIGMLVVGTSLLCVPLA--HNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDL-------RHTSVYGSVY 430
Cdd:COG2211 288 AKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYdewktgrRREGLYFGIF 367

                       330       340
                ....*....|....*....|....*..
gi 4506987  431 AIADVafcMGFAIGPSTGGAIVKAIGF 457
Cdd:COG2211 368 TFAIK---LGQALAGALAGLLLALFGY 391
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 139-479 8.65e-14

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 73.03  E-value: 8.65e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  139 VGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASV 218
Cdd:cd17329  37 VGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADV 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  219 YTDDHeRGRAMGTALGGLALGLLVGAPFGSVMYEFvGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLF---- 294
Cdd:cd17329 117 TTPEN-RTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILrgyk 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  295 MLLKD-PYILVAAGSICFAnMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGM 373
Cdd:cd17329 195 IVLRDrAFLLFLLASFLIS-LIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGI 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  374 LVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIadvAFCMGFAIGPSTGGAIVK 453
Cdd:cd17329 274 LLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYAL---AWGLGRAIGPLVGGLLLD 350

                       330       340
                ....*....|....*....|....*.
gi 4506987  454 AIGFPWLMVITGVINIVYAPLCYYLR 479
Cdd:cd17329 351 LLGPGLPWLILAALGLIAAALLLGLQ 376
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 139-472 2.39e-13

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 71.49  E-value: 2.39e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  139 VGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAF-----SGTYTLLFVARTLQGIGSSFSSVAGLG 213
Cdd:cd06173  36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLAFLLGIASAFFGPARQA 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  214 MLASVyTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTP- 292
Cdd:cd06173 116 LLPEL-VPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLl 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  293 ------LFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRW 366
Cdd:cd06173 195 rdlregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRG 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  367 LCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDlrhTSVYGSVYAIADVAFCMGFAIGPS 446
Cdd:cd06173 275 RLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVP---DELRGRVFSVYNALNSGAMPLGAL 351

                       330       340
                ....*....|....*....|....*.
gi 4506987  447 TGGAIVKAIGFPWLMVITGVINIVYA 472
Cdd:cd06173 352 LAGLLADALGLSAVFLLAGALLLLAA 377
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 139-470 1.28e-12

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 69.14  E-value: 1.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  139 VGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAglGMLASV 218
Cdd:cd17330  36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVA--QAYIAD 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  219 YTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLilaflalldgalqlcilqpskVSPESAKGTPLFMLLK 298
Cdd:cd17330 114 ITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFL---------------------VAAALALLNLVLVLFF 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  299 DPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLI-GTNLFGVLANKMGRWLCSLIGMLVVG 377
Cdd:cd17330 173 LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILaQLLLIPRLAKRLGERKLLRLGLLLAI 252

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  378 TSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDlrhTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGF 457
Cdd:cd17330 253 IGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVP---SKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGP 329

                       330
                ....*....|...
gi 4506987  458 PWLMVITGVINIV 470
Cdd:cd17330 330 GVPFLLAAGLLLI 342
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
137-486 1.55e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 69.14  E-value: 1.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  137 TRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLA 216
Cdd:COG2223  40 AQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVS 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  217 SVYTDDHeRGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPL--- 293
Cdd:COG2223 120 KWFPPDR-RGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLrdq 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  294 FMLLKDP--YILVAAGSICFAnMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSyLIGTNLFGVLANKMGRWLCSLI 371
Cdd:COG2223 199 LEALRDPrfWLLSLLYFGTFG-SFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLG-ALGRPLGGWLSDRIGGRRVLLI 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  372 GMLVVGTSLLCVPLA-HNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHtsvYGSVYAIADVAFCMGFAIGPSTGGA 450
Cdd:COG2223 277 VFALMALGLLLLALAlGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKN---AGAVYGLVGAAGGLGGFLGPLLFGA 353

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 4506987  451 IVKAIG-FPWLMVITGVINIVYAPLCYYLRSPPAKEE 486
Cdd:COG2223 354 LLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
136-476 1.38e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 66.03  E-value: 1.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  136 ITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGML 215
Cdd:COG0738  42 DAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYV 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  216 ASVYtddHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLAlldGALQLCIL----------QPSKVSP 285
Cdd:COG0738 122 AALG---PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLIL---AVLLLLLAllflrsklpeIEEEEEE 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  286 ESAKGTPLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGR 365
Cdd:COG0738 196 AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP 275

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  366 WLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVafcmGFAIGP 445
Cdd:COG0738 276 VRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIV----GGAIGP 351

                       330       340       350
                ....*....|....*....|....*....|....
gi 4506987  446 STGGAIVKAIGF---PWLMVITGVINIVYAPLCY 476
Cdd:COG0738 352 PLIGFLADAFGLraaFLVPLVCYLLILLLALALK 385
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 137-478 2.09e-11

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 65.67  E-value: 2.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  137 TRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLA 216
Cdd:cd17474  34 AQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIG 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  217 SVYTDDhERGRAMGTALGGLAlgllvgapFGSVMYEFVGKS-------APFLILAFLALLDGALQLCILQPSKVSPESAK 289
Cdd:cd17474 114 DLFEGG-ERAKAMGLYEAALG--------LGIAVGPLLGGLlaaiswrYPFFLLAALIPVAFLAILFLLPEPKEKAKSSS 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  290 GTPLFML---LKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFG-VLANKMGR 365
Cdd:cd17474 185 ATKLRDLkkaLRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGA 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  366 WLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYaiaDVAFCMGFAIGP 445
Cdd:cd17474 265 RRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLY---NFVRFLGQAVGP 341

                       330       340       350
                ....*....|....*....|....*....|...
gi 4506987  446 STGGAIVKAIGFPWLMVITGVINIVYAPLCYYL 478
Cdd:cd17474 342 LLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 139-478 2.27e-11

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 65.32  E-value: 2.27e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  139 VGVLFASKAVMQLLVNPFVGPLTNRIGYHIP-MFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFsSVAGLGMLAS 217
Cdd:cd17490  33 IGIILGAYGISQMLLRIPLGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAAT-WVSFTVLYAS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  218 VYTDDhERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLdGALQLCILQPSKVSPESAKGTP--LFM 295
Cdd:cd17490 112 YFPPD-EAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVL-GFILSLFIKEERREKKPVLTELkeLLS 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  296 LLKDPYILVA---AGSICFANMGVAIlePTLPIWMMQTMCSpKWQLGLAFLPASVSYLIGTNLFGVLA-NKMGRWLCSLI 371
Cdd:cd17490 190 VLKDKKLLFFsllAILQQMITFSTTF--GFTPLIAKQLGAS-SFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIII 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  372 GMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMM--PIMGHLVDLRHTSV--YGSVYAIadvafcmGFAIGPST 447
Cdd:cd17490 267 GFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMslSIEGVPAEQRSTAMgfFQAIYAL-------GMFLGPVL 339

                       330       340       350
                ....*....|....*....|....*....|.
gi 4506987  448 GGAIVKAIGFPWLMVITGVINIVYAPLCYYL 478
Cdd:cd17490 340 VGIISEAFGLQTGFFVIGVIALLAAILSLAY 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
302-489 4.57e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 64.22  E-value: 4.57e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  302 ILVAAGSICFANMGVAILEPTLPiWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLL 381
Cdd:COG2814  12 LLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  382 CVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHtsvYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLM 461
Cdd:COG2814  91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPER---RGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167

                       170       180       190
                ....*....|....*....|....*....|
gi 4506987  462 VITGVINIVYAPLCYYL--RSPPAKEEKLA 489
Cdd:COG2814 168 LVNAVLALLALLLLLRLlpESRPAARARLR 197
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 308-487 1.03e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 63.36  E-value: 1.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  308 SICFANMGVAILEPTLPIWMMQTMCSPKwQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAH 387
Cdd:cd17325   4 ALFLDMLGYGIIIPILPLYAESLGASVA-QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  388 NIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTsvyGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVI 467
Cdd:cd17325  83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEER---GRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159

                       170       180
                ....*....|....*....|
gi 4506987  468 NIVYAPLCYYLRSPPAKEEK 487
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPN 179
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 149-452 7.83e-10

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 60.64  E-value: 7.83e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  149 MQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVART-LQGIGSSFSSVAGLGMLASVYtdDHERGR 227
Cdd:cd17352  50 VSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGvLGGLGLGLIYSPAIVIVGQYF--EKKRGL 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  228 AMGTALGGLALGLLVGAPFGSVMYEFVGksapflilaflalldgaLQLCILQPSKVSPESAKGTPLFMLLKDPYILVAAG 307
Cdd:cd17352 128 ATGIAVAGSGVGTFVFPPLLRYLLDNYG-----------------WRGALLILGGLCLNLCVCGLLLRLLKDPTFVLLAL 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  308 SICFANMGvailEPTLPIWMMQTMCSPKWQLGLAFLPAS---VSYLIGTNLFGVLANK--MGRWLCSLIGMLVVGTSLLC 382
Cdd:cd17352 191 GVSFAMLG----FFVPFVYLPSYAKSLGIDESDAAFLLSiigISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLA 266

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4506987  383 VPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRH-TSVYGSVYAIAdvafCMGFAIGPSTGGAIV 452
Cdd:cd17352 267 FPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKlSNAYGLVLLFQ----GLAALVGPPIAGLLR 333
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 139-467 1.63e-09

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 59.90  E-value: 1.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  139 VGVLFASKAVMQLlvnpFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASV 218
Cdd:cd17320  40 LSAYLLGFALGQL----LYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  219 YtDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCIL---QPSKVSPESAKGTP--L 293
Cdd:cd17320 116 Y-SGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLpetLPEEKRKPLLSSLLraY 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  294 FMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMG-----RWLC 368
Cdd:cd17320 195 KRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGprrllRLGL 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  369 SLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRH---TSVYGSVYAIadVAFCMGFAIGP 445
Cdd:cd17320 275 LLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAgtaSALLGFLQFL--IGALAGALVGL 352

                       330       340
                ....*....|....*....|..
gi 4506987  446 STGGAivkAIGFPWLMVITGVI 467
Cdd:cd17320 353 LPNGT---ALPMGLLILVLGLL 371
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 155-452 3.46e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 55.64  E-value: 3.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  155 PFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYtDDHERGRAMGTALG 234
Cdd:cd17321  49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATF-PGERRGRALGLWGA 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  235 GLALGLLVGAPFGSVMYEFVG------KSAPflilaflalldgalqLCILqpskvspeSAKGTPLFMLlkdpyILVAAGS 308
Cdd:cd17321 128 VVGIGAALGPLLGGLLLELFGwrwiflINVP---------------IGLV--------ALLLARTFSG-----AVLAAFL 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  309 ICFANMGVAILeptLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHN 388
Cdd:cd17321 180 LGAALGGLLFL---LPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGA 256

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4506987  389 -------IFGLIGPNAGLGLAIGMVDSSMMPIMGHlvdlrhtSVYGSVYAIADVAFCMGFAIGPSTGGAIV 452
Cdd:cd17321 257 dssvwllLPGLVLLGLGLGLFATPLTNAALSSVPK-------EKAGAASGILNTARQLGGALGVALLGALL 320
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 139-229 2.30e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 52.51  E-value: 2.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  139 VGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASV 218
Cdd:COG0477  51 LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAEL 130

                        90
                ....*....|.
gi 4506987  219 YTdDHERGRAM 229
Cdd:COG0477 131 FP-ARERGRAL 140
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 302-478 3.22e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 52.12  E-value: 3.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  302 ILVAAGSICFANMGVAILEPTLPIwMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLL 381
Cdd:COG0477  16 LLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  382 CVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIAdvaFCMGFAIGPSTGGAIVKAIGFPWLM 461
Cdd:COG0477  95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA---IGLGLALGPLLGGLLVAALGWRWIF 171

                       170
                ....*....|....*..
gi 4506987  462 VITGVINIVYAPLCYYL 478
Cdd:COG0477 172 LINAPLGLLALVLRLRL 188
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 139-470 4.20e-07

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 52.22  E-value: 4.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  139 VGVLFASKAVMQLlvnPFvGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGsSFSSVAgLGMLASv 218
Cdd:cd17472  38 LGIYGLTQAIFQI---PF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG-AISSVV-MALLAD- 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  219 YTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFM--L 296
Cdd:cd17472 111 LTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLkkL 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  297 LKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMcSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGR-WLCSLIGMLV 375
Cdd:cd17472 191 LKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLG-GGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKmKQVFVSSILL 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  376 VGTSLLCV-PLAHNIFGLIgpnagLGLAIGMVDSSMM-PIMGHLV-DLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAIV 452
Cdd:cd17472 270 IAVGFLLLlFAATSLWLLI-----IGLIIFFIGFNLLeALLPSLVsKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLW 344

                       330
                ....*....|....*...
gi 4506987  453 KAIGFPWLMVITGVINIV 470
Cdd:cd17472 345 GLLGYSSVFLTILILALL 362
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
137-229 5.30e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.90  E-value: 5.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  137 TRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLA 216
Cdd:COG2814 243 SAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322

                        90
                ....*....|...
gi 4506987  217 SVYtDDHERGRAM 229
Cdd:COG2814 323 ELA-PPEARGRAS 334
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
295-487 6.07e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.78  E-value: 6.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  295 MLLKDPYILVAAGSICFANMGV--AILEPTLPIwmMQTMCS-PKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLI 371
Cdd:COG0738   1 MSKKNYRRALIAIYLLFFLWGFatALWGPLIPA--LKDAFGlSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  372 GMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTsvygSVYAIADVAFCMGFAIGPSTGGAI 451
Cdd:COG0738  79 GLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAA----SRLNLLHAFFSLGALLGPLLGGLL 154

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 4506987  452 VKA---IGFPWLMVITGVINIVYAPLCYYLRSPPAKEEK 487
Cdd:COG0738 155 ILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEE 193
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 309-484 8.31e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.06  E-value: 8.31e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  309 ICFAN----MGVAILEPTLPIWMMQTMCSPKwQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVP 384
Cdd:cd17489   1 ILLANffffLSFYLLLPVLPLYAHDLGGSEA-VAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  385 LAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIAdvaFCMGFAIGPSTGGAIVKAIGFPWLMVIT 464
Cdd:cd17489  80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLA---TTLAMALGPALGLFLYQHLGFAVLFIVA 156

                       170       180
                ....*....|....*....|
gi 4506987  465 GVINIVYAPLCYYLRSPPAK 484
Cdd:cd17489 157 AVLALLALLLVFLVKDPPPV 176
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 139-474 1.10e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 50.63  E-value: 1.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  139 VGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASV 218
Cdd:cd17477  33 IGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNAL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  219 yTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVgkSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLK 298
Cdd:cd17477 113 -ATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG--ALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRI 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  299 DPYILVAAGSICFANMGVAILeptLPIWMMQTMCSPKWqlglAFLPASVSYLIGTNL---FGVLANKMGRWLCSLIGMLV 375
Cdd:cd17477 190 APLALLGAFVAGFLEGAFYSL---LPLYGLRLGLSVAQ----AALLLAAFVLGGLLLqwpLGWLADRFDRRRVLLGCALL 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  376 VGTSLLCVPLAHNIFGLIgpnAGLGLAIGMVDSSMMPI-MGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKA 454
Cdd:cd17477 263 GALAALLLPLVPGLPLAL---LVLLFLWGGAAGPLYTLaLALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDA 339

                       330       340
                ....*....|....*....|
gi 4506987  455 IGFPWLMVITGVINIVYAPL 474
Cdd:cd17477 340 FGPHGLFLFLAAVALLFLLF 359
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 152-472 1.20e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 47.65  E-value: 1.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  152 LVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGT 231
Cdd:cd17355  53 LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGI 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  232 ALGGLALGLLVGAPFGSVMYEFVG--------------KSAPFLILAFLALLDGALQLCILQPSKVSPESAKGtplfmLL 297
Cdd:cd17355 133 LTAGGGLGSLVFLPLGAALIEAFGwrtallvlallallVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKE-----AL 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  298 KDPYILVAAGSICFANMGVAILEPTLPIwMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVG 377
Cdd:cd17355 208 RSASFWLLALAFFLCGFAVVGLIVHLVP-YLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRA 286

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  378 TSLLCVPLAHN-IFGLIGPNAGLGLAIGmvdSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIG 456
Cdd:cd17355 287 LGLALLLLLPFpPLALLLFAALFGLGWG---ATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG 363

                       330
                ....*....|....*..
gi 4506987  457 -FPWLMVITGVINIVYA 472
Cdd:cd17355 364 sYTAAWALAVALGLIAA 380
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 140-228 2.77e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 46.42  E-value: 2.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  140 GVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYT---LLFVARTLQGIGSSFSSVAgLGMLA 216
Cdd:cd17503 217 GLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTslwLIILPLFIRGLGMGLVFMP-LNTLA 295

                        90
                ....*....|..
gi 4506987  217 SVYTDDHERGRA 228
Cdd:cd17503 296 LNSLPPEQIGDA 307
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 311-472 4.61e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 45.68  E-value: 4.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  311 FANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHNIF 390
Cdd:cd17329  10 LNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  391 GLIGPNAGLGLAIGMVDSSMMPIMGHLVDlrhTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAiGFPWLMVITGVINIV 470
Cdd:cd17329  90 LFAIALVLTGFGGGLFEPASEAMIADVTT---PENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLL 165


                ..
gi 4506987  471 YA 472
Cdd:cd17329 166 AA 167
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 312-488 5.31e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 45.70  E-value: 5.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  312 ANMGVAILEPTLPIWMMQTmcspkwqlglAFLPASVSYLIgtnlFGVLANKMGR-------WLCSLIGMLVVGTsllcvp 384
Cdd:cd06179  22 PFIVADLGPSSNSTWISTA----------WSLAQAVLGPI----VGRLSDLFGRrwffiggNLLGVVGSIVAGT------ 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  385 lAHNIFGLIGPNAGLGLAIGMVdSSMMPIMGHLVDLRHTsvyGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPW----- 459
Cdd:cd06179  82 -AKSVNMLIGGQALIGIGAGTQ-GLGAAVASELVPNKYR---GLVQGVVNLVASPGSALGPLIAGALVEANAAGWrwify 156

                       170       180
                ....*....|....*....|....*....
gi 4506987  460 LMVITGVINIVYAPLCYYLRSPPAKEEKL 488
Cdd:cd06179 157 INAIFNALALILLFFFYHPPPRPQLHGSS 185
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 147-225 9.33e-05

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 44.90  E-value: 9.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  147 AVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAF--SGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHE 224
Cdd:cd17332 266 LSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFlpPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGEL 345


                .
gi 4506987  225 R 225
Cdd:cd17332 346 K 346
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
131-225 1.12e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.51  E-value: 1.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  131 FLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSG--TYTLLFVARTLQGIGSSFSS 208
Cdd:COG2211 258 VLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAIL 337

                        90
                ....*....|....*..
gi 4506987  209 VAGLGMLASVYTDDHER 225
Cdd:COG2211 338 VLPWAMLADVVDYDEWK 354
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 100-229 2.58e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 43.33  E-value: 2.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  100 IAWMNDTASTIPPPATEAISAHknnclqgtgFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFL 179
Cdd:cd17473   7 ASTLTVMAGAAIAPALPAIAQH---------FVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGI 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 4506987  180 STVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYtDDHERGRAM 229
Cdd:cd17473  78 GGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYF-EGEERAKML 126
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 175-451 2.75e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 43.34  E-value: 2.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  175 VIMFLSTVMFAFSGTYTLLFVARTLQGIGssfSSVAGLGM-LASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEF 253
Cdd:cd17504  69 AIYTAGSLLAAFAPNLPVLIAGRALQGIG---GAVFPLAFaLVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQH 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  254 VGKSAPFLILAFLALLDGALqlcilqpskvspesakgTPLF--MLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQtm 331
Cdd:cd17504 146 LGWRWIFWTAAPVAVLLAAL-----------------VPLIdlRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQL-- 206

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  332 csPKW--------QLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAH-NIFGLIGPNAGLGLA 402
Cdd:cd17504 207 --PTPtgfglgitEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHsSLWALVVALLLIGIG 284

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4506987  403 IGMVDSSMMPIMGHLVDLRHTSVYGSVYAiadVAFCMGFAIGPSTGGAI 451
Cdd:cd17504 285 LGLAFASLPNIVVESVPPDRTGIATGMNT---VLRTIGSAIGPAIAGAI 330
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 140-472 2.80e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 43.41  E-value: 2.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  140 GVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSvAGLGMLASVy 219
Cdd:cd17391  39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVP-NATALIASQ- 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  220 TDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLC----ILQPSKVSpESAKGTPLFM 295
Cdd:cd17391 117 TPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFfvkeDFKPVEKK-KMVSTKEVWN 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  296 LLKDPYILVAAGSICFAN-MGVAILEPTLPIWMMQTMCSPKWQL---GLAFLPASVSYLIGTNLFGVLANKMGRWLCSLI 371
Cdd:cd17391 196 SVPNPSLLISLFVTTFIIqLANQSIEPILTLYIRQLMGDASNLAfisGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLG 275

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  372 GMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDlrhTSVYGSVYAIADVAFCMGFAIGPSTGGAI 451
Cdd:cd17391 276 ALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITP---KEVAGRIFGYNQSFQYLGNVAGPLLGSAI 352

                       330       340
                ....*....|....*....|....
gi 4506987  452 VKAIGFPWLMVITG---VINIVYA 472
Cdd:cd17391 353 AAHFGYRAVFVVTAllvLLNAIWS 376
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 137-229 4.31e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.54  E-value: 4.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  137 TRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLA 216
Cdd:cd17478  31 AQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLAS 110

                        90
                ....*....|...
gi 4506987  217 SVYTDDheRGRAM 229
Cdd:cd17478 111 QAAGGR--RGLAM 121
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 156-229 1.08e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 41.41  E-value: 1.08e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4506987  156 FVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGI-GSSFSSVAGlGMLASVYTDdHERGRAM 229
Cdd:cd17323  53 IWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFfGSSPLAIGA-GTIADLFTP-EERGKAM 125
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
139-229 1.99e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 40.63  E-value: 1.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  139 VGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASV 218
Cdd:COG2807  55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRW 134

                        90
                ....*....|.
gi 4506987  219 YtdDHERGRAM 229
Cdd:COG2807 135 F--PDRVGLMT 143
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 355-470 2.44e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.23  E-value: 2.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  355 LFGVLANKMGRWLCSLIGMLVVG-TSLLCVpLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRH----TSVYGSV 429
Cdd:cd17321  50 LAGRLGDRFGRKRVFLIGLALFGlASLLCA-LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERrgraLGLWGAV 128

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 4506987  430 YAIadvafcmGFAIGPSTGGAIVKAIGFPWLMVITGVINIV 470
Cdd:cd17321 129 VGI-------GAALGPLLGGLLLELFGWRWIFLINVPIGLV 162
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 136-217 4.48e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.48  E-value: 4.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  136 ITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYT-LLFVARTLQGIGSSFSSVAGLGM 214
Cdd:cd17504 216 ITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLwALVVALLLIGIGLGLAFASLPNI 295


                ...
gi 4506987  215 LAS 217
Cdd:cd17504 296 VVE 298
emrD PRK11652
multidrug transporter EmrD;
156-203 4.57e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 39.51  E-value: 4.57e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 4506987   156 FVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIG 203
Cdd:PRK11652  62 FYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 137-218 5.94e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.08  E-value: 5.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  137 TRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAF---SGTYTLLFVARTLQGIGSSFSSVAGLG 213
Cdd:cd17321 204 LQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALlgaDSSVWLLLPGLVLLGLGLGLFATPLTN 283


                ....*
gi 4506987  214 MLASV 218
Cdd:cd17321 284 AALSS 288
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 310-484 6.20e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.14  E-value: 6.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  310 CFANMGVAILEPTLPIWMMQTMCSPKWqLGLAFLPASVSYLIGTNLFGVLANKMGR-----WLCSLIGMLVVGTSLLCVP 384
Cdd:cd06173   9 LLSALGDWIFTVALPWLVLQLTGSALL-VGLVLAAFFLPFLLFSPFAGVLADRFDRrrlliLADLLRALLAAVLALLALL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  385 LAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHtsvYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVIT 464
Cdd:cd06173  88 GSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQ---LVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN 164

                       170       180
                ....*....|....*....|
gi 4506987  465 GVINIVYAPLCYYLRSPPAK 484
Cdd:cd06173 165 ALSFLLSALLLLFIRRPPPA 184
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 137-211 6.29e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.16  E-value: 6.29e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4506987  137 TRVGVLFASKAVMQLLVNPFVGPLTNRIGYH---IPMFAGFVIMFLstvMFAFSGTYTLLFVARTLQGIGSSFSSVAG 211
Cdd:cd17388  38 THYGVLLALYALMQFIFAPILGALSDRFGRRpvlLLSLAGAALDYL---LMAFAPTLWWLYLGRIIAGITGATGAVAA 112
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 140-229 6.57e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 6.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  140 GVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVY 219
Cdd:cd17473 236 GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLV 315

                        90
                ....*....|
gi 4506987  220 TDDHeRGRAM 229
Cdd:cd17473 316 PPEL-RGRAM 324
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 337-478 6.58e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 38.71  E-value: 6.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  337 QLGLAFLPASVSYLIGTNLFGVLANKMG--RWLcsLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGmvdsSMMPIM 414
Cdd:cd17319  39 QYGLIASAFFLGYALFQVPGGWLLDRFGarKVL--AVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA----GFFPGA 112

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4506987  415 GHLVDLRHTSVY-GSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYL 478
Cdd:cd17319 113 IKALAEWFPARErGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFY 177
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 322-474 8.31e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 38.68  E-value: 8.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  322 TLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGL 401
Cdd:cd17370 220 AFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGL 299

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4506987  402 AIGMVDSSMMPIMGHLVDLRHTsvyGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPL 474
Cdd:cd17370 300 YMGAQESIERAAVADLVPAELR---GTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 317-487 9.89e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.31  E-value: 9.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  317 AILEPTLPIwMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIgpn 396
Cdd:cd17478  13 GFLPALLPL-LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLL--- 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  397 agLGLAIGMVDSSMM-PIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAIV---KAIGFPWLMVITGVINIVYA 472
Cdd:cd17478  89 --LLVALAGIGSAAFhPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALValfGGLGLLILLIIPGLAVALLL 166

                       170
                ....*....|....*
gi 4506987  473 PLCYYLRSPPAKEEK 487
Cdd:cd17478 167 LRLRPLKKPEAKKAA 181
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 156-467 9.98e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 38.35  E-value: 9.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  156 FVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGssfssVAGLGMLASVYTDDHERGRAMGTALGG 235
Cdd:cd17316  55 LFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIG-----IGGEYPGASTYVAEFAPSKRRGFALGL 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  236 LALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALqlcilqpskvspesakgTPLFMLLKDPYILVAAGSICFANMG 315
Cdd:cd17316 130 LQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGAL-----------------PALLALLLRRRTLLLILLWFFISFG 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506987  316 VAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGR--WLCSLIGMLVVGTSLLCVPLAHNIFGLI 393
Cdd:cd17316 193 YYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRkkTLVIGLILSGILALPLFYLLSGSPTLLL 272

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4506987  394 gpnAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKA---IGFPWLMVITGVI 467
Cdd:cd17316 273 ---LLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAStggTGVPALILALLAI 346
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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