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Conserved domains on  [gi|4506857|ref|NP_002987|]
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fractalkine isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chemokine_CX3C cd00274
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 25-100 1.51e-52

Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups.


:

Pssm-ID: 238172  Cd Length: 76  Bit Score: 169.48  E-value: 1.51e-52
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4506857   25 QHHGVTKCNITCSKMTSKIPVALLIHYQQNQASCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNG 100
Cdd:cd00274   1 QHHGVTKCNITCSKMTSKIPVALLIHYQQNQESCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNG 76
dnaA super family cl42516
chromosomal replication initiator protein DnaA;
131-324 1.78e-04

chromosomal replication initiator protein DnaA;


The actual alignment was detected with superfamily member PRK14086:

Pssm-ID: 455861 [Multi-domain]  Cd Length: 617  Bit Score: 43.66  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857   131 ATGESSSLEPTPSSQEAQRAlgTSPELPT-GVTGSSGTRLPPTPKAQDGGPVGTELFRVPPVSTAATWQSS-APHQPGPS 208
Cdd:PRK14086  86 ITVDPSAGEPAPPPPHARRT--SEPELPRpGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEpGAWPRAAD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857   209 LWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRV-----WGQGQSPRPE----NSLEREEMGPVPAHTDAFQDWG 279
Cdd:PRK14086 164 DYGWQQQRLGFPPRAPYASPASYAPEQERDREPYDAGRPeydqrRRDYDHPRPDwdrpRRDRTDRPEPPPGAGHVHRGGP 243

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 4506857   280 PGSMAHVSVVPVSSEGTPSREPvASGSWTPKAEEPiHATMDPQRL 324
Cdd:PRK14086 244 GPPERDDAPVVPIRPSAPGPLA-AQPAPAPGPGEP-TARLNPKYT 286
 
Name Accession Description Interval E-value
Chemokine_CX3C cd00274
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 25-100 1.51e-52

Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups.


Pssm-ID: 238172  Cd Length: 76  Bit Score: 169.48  E-value: 1.51e-52
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4506857   25 QHHGVTKCNITCSKMTSKIPVALLIHYQQNQASCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNG 100
Cdd:cd00274   1 QHHGVTKCNITCSKMTSKIPVALLIHYQQNQESCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNG 76
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 36-89 1.42e-18

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 78.83  E-value: 1.42e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 4506857      36 CSKMTSK-IPVALLIHYQQNQASCGKRAIILETRQHRLFCADPKEQWVKDAMQHL 89
Cdd:smart00199   5 CLSYTSKkIPLKRIKSYYPTSSHCPKPAVIFTTKKGRKVCADPKAKWVQRYIKKL 59
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 30-89 1.77e-13

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 64.60  E-value: 1.77e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4506857     30 TKCnitCSKMTSK-IPVALLIHYQQNQAS--CGKRAIILETRQHRLFCADPKEQWVKDAMQHL 89
Cdd:pfam00048   1 SDC---CLRYSSKpIPLKRVKSYEIQPASssCPKPAVIFLTKKGRQVCADPKAKWVQRLIKKL 60
dnaA PRK14086
chromosomal replication initiator protein DnaA;
131-324 1.78e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 43.66  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857   131 ATGESSSLEPTPSSQEAQRAlgTSPELPT-GVTGSSGTRLPPTPKAQDGGPVGTELFRVPPVSTAATWQSS-APHQPGPS 208
Cdd:PRK14086  86 ITVDPSAGEPAPPPPHARRT--SEPELPRpGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEpGAWPRAAD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857   209 LWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRV-----WGQGQSPRPE----NSLEREEMGPVPAHTDAFQDWG 279
Cdd:PRK14086 164 DYGWQQQRLGFPPRAPYASPASYAPEQERDREPYDAGRPeydqrRRDYDHPRPDwdrpRRDRTDRPEPPPGAGHVHRGGP 243

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 4506857   280 PGSMAHVSVVPVSSEGTPSREPvASGSWTPKAEEPiHATMDPQRL 324
Cdd:PRK14086 244 GPPERDDAPVVPIRPSAPGPLA-AQPAPAPGPGEP-TARLNPKYT 286
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 129-337 9.73e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.44  E-value: 9.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857    129 PEATGESSSLEPTP-SSQEAQRALGTSPELPTGVTGSSGTrlPPTPKAQDggpvgtelfrVPPVSTAATWQSSAPHQPGP 207
Cdd:pfam05109 425 PESTTTSPTLNTTGfAAPNTTTGLPSSTHVPTNLTAPAST--GPTVSTAD----------VTSPTPAGTTSGASPVTPSP 492

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857    208 SLWAEAKTSEAPSTQDPSTQAST----ASSPAPEENAPSEGQR--VWGQGQSPRPENSLEREEMGPVPAHTDAFQDWGPG 281
Cdd:pfam05109 493 SPRDNGTESKAPDMTSPTSAVTTptpnATSPTPAVTTPTPNATspTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIP 572

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4506857    282 SMAHVSVVPVSSEGTPSREPVASGSWTPKAEEPIHATMDPQRLGVLITPVPDAQAA 337
Cdd:pfam05109 573 TLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSA 628
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 112-246 6.04e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 38.59  E-value: 6.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857   112 PRTTPAAGGMDESVVLEPEATGESSSLEPTPSSQEAQRALGTSPELPTGVTGSSGTRLPPTPKAQDGGPVGTELFRVPPV 191
Cdd:NF040712 197 RPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPDEATRD 276

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 4506857   192 STAATWQSSAPHQPgpslwAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQR 246
Cdd:NF040712 277 AGEPPAPGAAETPE-----AAEPPAPAPAAPAAPAAPEAEEPARPEPPPAPKPKR 326
 
Name Accession Description Interval E-value
Chemokine_CX3C cd00274
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 25-100 1.51e-52

Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups.


Pssm-ID: 238172  Cd Length: 76  Bit Score: 169.48  E-value: 1.51e-52
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4506857   25 QHHGVTKCNITCSKMTSKIPVALLIHYQQNQASCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNG 100
Cdd:cd00274   1 QHHGVTKCNITCSKMTSKIPVALLIHYQQNQESCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNG 76
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 36-89 1.42e-18

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 78.83  E-value: 1.42e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 4506857      36 CSKMTSK-IPVALLIHYQQNQASCGKRAIILETRQHRLFCADPKEQWVKDAMQHL 89
Cdd:smart00199   5 CLSYTSKkIPLKRIKSYYPTSSHCPKPAVIFTTKKGRKVCADPKAKWVQRYIKKL 59
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 35-90 3.06e-18

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 78.15  E-value: 3.06e-18
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4506857   35 TCSKMTSK-IPVALLIHYQQNQAS--CGKRAIILETRQHRLFCADPKEQWVKDAMQHLD 90
Cdd:cd00169   1 CCLKYTSKpIPPKNIKSYRVQEAGghCSIPAVIFTTKKGRKVCADPKEPWVKDLIQKLD 59
Chemokine_CC cd00272
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 36-90 4.27e-15

Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD.


Pssm-ID: 238170  Cd Length: 57  Bit Score: 69.20  E-value: 4.27e-15
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4506857   36 CSKMTSK-IPVALLIHYQQNQASCGKRAIILETRQHRLFCADPKEQWVKDAMQHLD 90
Cdd:cd00272   2 CLSYSKKrIPLRVLKSYRRTSSSCSKPAVIFKTKRGREVCADPKQKWVQRYMKLLD 57
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 30-89 1.77e-13

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 64.60  E-value: 1.77e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4506857     30 TKCnitCSKMTSK-IPVALLIHYQQNQAS--CGKRAIILETRQHRLFCADPKEQWVKDAMQHL 89
Cdd:pfam00048   1 SDC---CLRYSSKpIPLKRVKSYEIQPASssCPKPAVIFLTKKGRQVCADPKAKWVQRLIKKL 60
Chemokine_CC_DCCL cd01119
Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL ...
 50-90 1.34e-09

Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by blocking progression through the cell cycle; DCCL subgroup contains Exodus-1 (also known as CCL20, MIP-3alpha, LARC, ST38 (mouse)), Exodus-2 (also known as CCL21, SLC, 6-Ckine, TCA4, CKbeta9), and Exodus-3 (also known as CCL-19, ELC, MIP-3beta, CKbeta11). Exodus-3 was shown to inhibit the growth of human breast cancer cells in vivo in a mouse model; Exodus-1, -2, and -3 were all shown to significantly inhibit chronic myelogenous leukemia progenitor cell proliferation; Exodus-2 and -3 show potent immunotherapeutic activity toward solid tumors; chemotatic for T cells, B cells, dendritic cells, macrophage progenitor cells, and NK cells; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates. See CDs: Chemokine_CC (cd00272) for the entire CC subgroup, Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238539  Cd Length: 61  Bit Score: 53.56  E-value: 1.34e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 4506857   50 HYQQNQASCGKRAIILETRQHRLFCADPKEQWVKDAMQHLD 90
Cdd:cd01119  21 TYQEISESCDIPAIIFHTRRGRKVCADPKQDWVKRAIQLLS 61
Chemokine_C cd00271
Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on ...
 40-95 1.25e-06

Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on the arrangement of two N-terminal, conserved cysteine residues. Most of the known chemokines (cd00169) belong to either the CC (cd00272) or CXC (cd00273) subclass. The two other subclasses each have a single known member: fractalkine for the CX3C (cd00274) class and lymphotactin for the C (cd00271) class. Chemokine_Cs differ structurally since they contain only one of the two disulfide bridges that are conserved in all other chemokines and they possess a unique C-terminal extension, which is required for biological activity and thought to play a role in receptor binding. Lymphotactin, a mediator of mucosal immunity, has been found to chemoattract neutrophils and B cells through the XCR1 receptor and thought to be a factor in acute allograft rejection and inflammatory bowel disease.


Pssm-ID: 238169  Cd Length: 72  Bit Score: 45.62  E-value: 1.25e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4506857   40 TSKIPVALLIHYQQNQASCgkRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAA 95
Cdd:cd00271  16 TQRLPVQKIKTYTIKEGSV--RAVIFITKRGLKICADPQAKWVKSAVKTIDRRAST 69
dnaA PRK14086
chromosomal replication initiator protein DnaA;
131-324 1.78e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 43.66  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857   131 ATGESSSLEPTPSSQEAQRAlgTSPELPT-GVTGSSGTRLPPTPKAQDGGPVGTELFRVPPVSTAATWQSS-APHQPGPS 208
Cdd:PRK14086  86 ITVDPSAGEPAPPPPHARRT--SEPELPRpGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEpGAWPRAAD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857   209 LWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRV-----WGQGQSPRPE----NSLEREEMGPVPAHTDAFQDWG 279
Cdd:PRK14086 164 DYGWQQQRLGFPPRAPYASPASYAPEQERDREPYDAGRPeydqrRRDYDHPRPDwdrpRRDRTDRPEPPPGAGHVHRGGP 243

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 4506857   280 PGSMAHVSVVPVSSEGTPSREPvASGSWTPKAEEPiHATMDPQRL 324
Cdd:PRK14086 244 GPPERDDAPVVPIRPSAPGPLA-AQPAPAPGPGEP-TARLNPKYT 286
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 129-302 2.68e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.15  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857    129 PEATGESSSLEPTPSSQEAqralgTSPELPTGVTGSSGTRLPPTPKaqdggpvgtelFRVPPVSTAATWQSSAPHQPGPS 208
Cdd:PRK10263  345 PVASVDVPPAQPTVAWQPV-----PGPQTGEPVIAPAPEGYPQQSQ-----------YAQPAVQYNEPLQQPVQPQQPYY 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857    209 LWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRVWGQGQ----SPRPENSLEREEMGPVPAHTDAFQDWGPGSMA 284
Cdd:PRK10263  409 APAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQqstfAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQP 488

                         170
                  ....*....|....*...
gi 4506857    285 HVSVVPVSSEGTPSREPV 302
Cdd:PRK10263  489 VVEPEPVVEETKPARPPL 506
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 112-317 7.06e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 7.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857    112 PRTTPAAGGMDESVVLEPEATGESSSLEPTPSSQEAQRALGTSPELPTGVTGSSGTRLPPTPKAQDGGPVGTELFRVPPV 191
Cdd:PHA03307  100 PAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSP 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857    192 STAATWQSSAPHQPGPSLWAEAKTSEAPSTQDPSTQASTASSPAPEENA---------PSEGQRVWGQGQSPRPENSLER 262
Cdd:PHA03307  180 EETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAaddagasssDSSSSESSGCGWGPENECPLPR 259

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 4506857    263 EEMGPVPAHTDAFQDWGPGSMAHVSVVPVSSEGTPSREPVASGSWTPKAEEPIHA 317
Cdd:PHA03307  260 PAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRA 314
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 129-337 9.73e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.44  E-value: 9.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857    129 PEATGESSSLEPTP-SSQEAQRALGTSPELPTGVTGSSGTrlPPTPKAQDggpvgtelfrVPPVSTAATWQSSAPHQPGP 207
Cdd:pfam05109 425 PESTTTSPTLNTTGfAAPNTTTGLPSSTHVPTNLTAPAST--GPTVSTAD----------VTSPTPAGTTSGASPVTPSP 492

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857    208 SLWAEAKTSEAPSTQDPSTQAST----ASSPAPEENAPSEGQR--VWGQGQSPRPENSLEREEMGPVPAHTDAFQDWGPG 281
Cdd:pfam05109 493 SPRDNGTESKAPDMTSPTSAVTTptpnATSPTPAVTTPTPNATspTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIP 572

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4506857    282 SMAHVSVVPVSSEGTPSREPVASGSWTPKAEEPIHATMDPQRLGVLITPVPDAQAA 337
Cdd:pfam05109 573 TLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSA 628
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 115-314 2.93e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 2.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857   115 TPAAGGMDESVVLEPEATGESSSLEPTPSSQEAQRALGTSPELPTGVTGSSGTRLPPTPKAQDGGPVGTelfrVPPVSTA 194
Cdd:PRK07764 590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVA----VPDASDG 665

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857   195 ATWQSSAPHQPGPSLWAEAKTSEAPstQDPSTQASTASSPAPEENAPSE-GQRVWGQGQSPRPENSLERE---EMGPVPA 270
Cdd:PRK07764 666 GDGWPAKAGGAAPAAPPPAPAPAAP--AAPAGAAPAQPAPAPAATPPAGqADDPAAQPPQAAQGASAPSPaadDPVPLPP 743

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 4506857   271 HTDAFQDWGPGSMAHVSVVPVSSEGTPSREPvasgSWTPKAEEP 314
Cdd:PRK07764 744 EPDDPPDPAGAPAQPPPPPAPAPAAAPAAAP----PPSPPSEEE 783
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
169-342 5.97e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 38.70  E-value: 5.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857   169 LPPTPKAQDGGPVGTELFRVPPVSTAATWQSSAPHQPGPSLWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRVW 248
Cdd:PRK12323 363 FRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASAR 442

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857   249 GQGQSPRPENSlereeMGPVPAHTDAFQDWGPGSMAHVSVVPVSSEgTPSREPVASGSWTPKAEE-------PIHATMDP 321
Cdd:PRK12323 443 GPGGAPAPAPA-----PAAAPAAAARPAAAGPRPVAAAAAAAPARA-APAAAPAPADDDPPPWEElppefasPAPAQPDA 516

                        170       180
                 ....*....|....*....|.
gi 4506857   322 QRLGVLITPVPDAQAATRRQA 342
Cdd:PRK12323 517 APAGWVAESIPDPATADPDDA 537
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 112-246 6.04e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 38.59  E-value: 6.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857   112 PRTTPAAGGMDESVVLEPEATGESSSLEPTPSSQEAQRALGTSPELPTGVTGSSGTRLPPTPKAQDGGPVGTELFRVPPV 191
Cdd:NF040712 197 RPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPDEATRD 276

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 4506857   192 STAATWQSSAPHQPgpslwAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQR 246
Cdd:NF040712 277 AGEPPAPGAAETPE-----AAEPPAPAPAAPAAPAAPEAEEPARPEPPPAPKPKR 326
PHA03255 PHA03255
BDLF3; Provisional
 114-237 9.00e-03

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 37.58  E-value: 9.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857   114 TTPAAGGMDESVVLepeaTGESSSLEPTPSSQEAQRALGTSPELPTGVTG-------SSGTRLPPTPKAQDGGpvgtelf 186
Cdd:PHA03255  30 STASAGNVTGTTAV----TTPSPSASGPSTNQSTTLTTTSAPITTTAILStntttvtSTGTTVTPVPTTSNAS------- 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4506857   187 rVPPVSTAATWQSSAPHQPGPSLW---AEAKTSEAPSTQDPSTQASTASSPAPE 237
Cdd:PHA03255  99 -TINVTTKVTAQNITATEAGTGTStgvTSNVTTRSSSTTSATTRITNATTLAPT 151
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 128-323 9.31e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 38.23  E-value: 9.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857    128 EPEATGESSSLEPTPSSQEAQRALGTSPELPTGVTGSSGTRLPPTPKAQDGGP-------VGTELFRVPPVSTAATWQSS 200
Cdd:PHA03307   74 GPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPppspapdLSEMLRPVGSPGPPPAASPP 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506857    201 APHQPGPSLWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRVWGQGQSPRPENSLEREEMGPVPAHTDAfQDWGP 280
Cdd:PHA03307  154 AAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRS-AADDA 232

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 4506857    281 GSMAHVSVVPVSSE---------GTPSREPVASGSWTPKAEEPIHATMDPQR 323
Cdd:PHA03307  233 GASSSDSSSSESSGcgwgpenecPLPRPAPITLPTRIWEASGWNGPSSRPGP 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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