cardiac phospholamban [Homo sapiens]
Protein Classification
P_lamban family protein( domain architecture ID 10018779)
P_lamban family protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| P_lamban | TIGR01294 | phospholamban; This model represents the short (52 residue) transmembrane phosphoprotein ... |
1-52 | 3.48e-15 | ||
phospholamban; This model represents the short (52 residue) transmembrane phosphoprotein phospholamban. Phospholamban, in its unphosphorylated form, inhibits SERCA2, the cardiac sarcoplasmic reticulum Ca-ATPase. : Pssm-ID: 273541 Cd Length: 52 Bit Score: 61.47 E-value: 3.48e-15
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| Name | Accession | Description | Interval | E-value | ||
| P_lamban | TIGR01294 | phospholamban; This model represents the short (52 residue) transmembrane phosphoprotein ... |
1-52 | 3.48e-15 | ||
phospholamban; This model represents the short (52 residue) transmembrane phosphoprotein phospholamban. Phospholamban, in its unphosphorylated form, inhibits SERCA2, the cardiac sarcoplasmic reticulum Ca-ATPase. Pssm-ID: 273541 Cd Length: 52 Bit Score: 61.47 E-value: 3.48e-15
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| Phospholamban | cd20250 | Phospholamban bioactive peptide and similar proteins; Vertebrate phospholamban (PLN) belongs ... |
1-52 | 1.20e-11 | ||
Phospholamban bioactive peptide and similar proteins; Vertebrate phospholamban (PLN) belongs to a family of bioactive peptides which includes vertebrate sarcolipin (SLN), and the invertebrate sarcolamban (SCLA, and SCLB). SCLA and SCLB are encoded within a single putative noncoding transcript, pncr003:2L; PLN and SLN are each encoded within a single exon of a spliced transcript. PLN is chiefly expressed in the cardiac muscle, while SLN is expressed in the atria of the heart and embryonic slow-type skeletal muscle; SCL is found in cardiac and somatic muscle of Drosophila melanogaster. PLN and SLN are each a single-pass transmembrane alpha-helix that interacts directly with the sarcoplasmic reticulum (SR) calcium pump (SERCA), lower its affinity for Ca2+, thereby decreasing the rate of Ca2+ reuptake into the SR from the sarcoplasm. In the heart, PLN and SLN inhibit the activity of SERCA2a isoform and function as important regulators of cardiac contractibility and disease. SCLA and SCLB are each predicted to form a single-pass transmembrane helix, localize to the SR with the SR calcium pump (Ca-P60A), and dampen its activity. PLN and SLN differ in their interaction with SERCA; PLN is an affinity modulator of SERCA. It is thought to form a pentamer in the membrane. Pssm-ID: 380750 Cd Length: 52 Bit Score: 52.83 E-value: 1.20e-11
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| Phospholamban | pfam04272 | Phospholamban; The regulation of calcium levels across the membrane of the sarcoplasmic ... |
1-52 | 2.81e-08 | ||
Phospholamban; The regulation of calcium levels across the membrane of the sarcoplasmic reticulum involves the interplay of many membrane proteins. Phospholamban is a 52 residue integral membrane protein that is involved in reversibly inhibiting the Ca(2+) pump and regulating the flow of Ca ions across the sarcoplasmic reticulum membrane during muscle contraction and relaxation. Phospholamban is thought to form a pentamer in the membrane. Pssm-ID: 367891 Cd Length: 52 Bit Score: 44.20 E-value: 2.81e-08
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| Name | Accession | Description | Interval | E-value | ||
| P_lamban | TIGR01294 | phospholamban; This model represents the short (52 residue) transmembrane phosphoprotein ... |
1-52 | 3.48e-15 | ||
phospholamban; This model represents the short (52 residue) transmembrane phosphoprotein phospholamban. Phospholamban, in its unphosphorylated form, inhibits SERCA2, the cardiac sarcoplasmic reticulum Ca-ATPase. Pssm-ID: 273541 Cd Length: 52 Bit Score: 61.47 E-value: 3.48e-15
|
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| Phospholamban | cd20250 | Phospholamban bioactive peptide and similar proteins; Vertebrate phospholamban (PLN) belongs ... |
1-52 | 1.20e-11 | ||
Phospholamban bioactive peptide and similar proteins; Vertebrate phospholamban (PLN) belongs to a family of bioactive peptides which includes vertebrate sarcolipin (SLN), and the invertebrate sarcolamban (SCLA, and SCLB). SCLA and SCLB are encoded within a single putative noncoding transcript, pncr003:2L; PLN and SLN are each encoded within a single exon of a spliced transcript. PLN is chiefly expressed in the cardiac muscle, while SLN is expressed in the atria of the heart and embryonic slow-type skeletal muscle; SCL is found in cardiac and somatic muscle of Drosophila melanogaster. PLN and SLN are each a single-pass transmembrane alpha-helix that interacts directly with the sarcoplasmic reticulum (SR) calcium pump (SERCA), lower its affinity for Ca2+, thereby decreasing the rate of Ca2+ reuptake into the SR from the sarcoplasm. In the heart, PLN and SLN inhibit the activity of SERCA2a isoform and function as important regulators of cardiac contractibility and disease. SCLA and SCLB are each predicted to form a single-pass transmembrane helix, localize to the SR with the SR calcium pump (Ca-P60A), and dampen its activity. PLN and SLN differ in their interaction with SERCA; PLN is an affinity modulator of SERCA. It is thought to form a pentamer in the membrane. Pssm-ID: 380750 Cd Length: 52 Bit Score: 52.83 E-value: 1.20e-11
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| Phospholamban | pfam04272 | Phospholamban; The regulation of calcium levels across the membrane of the sarcoplasmic ... |
1-52 | 2.81e-08 | ||
Phospholamban; The regulation of calcium levels across the membrane of the sarcoplasmic reticulum involves the interplay of many membrane proteins. Phospholamban is a 52 residue integral membrane protein that is involved in reversibly inhibiting the Ca(2+) pump and regulating the flow of Ca ions across the sarcoplasmic reticulum membrane during muscle contraction and relaxation. Phospholamban is thought to form a pentamer in the membrane. Pssm-ID: 367891 Cd Length: 52 Bit Score: 44.20 E-value: 2.81e-08
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