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Conserved domains on  [gi|4505469|ref|NP_002518|]
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neurotrophin-3 isoform 2 preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NTF3_N pfam19338
Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) ...
20-133 2.35e-78

Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) which contains two precursor homology regions located upstream of the mature NTF3 sequence. These regions play important and specific roles in the folding, processing and transport of neurotrophic factors.


:

Pssm-ID: 437170  Cd Length: 114  Bit Score: 231.95  E-value: 2.35e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505469     20 NMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRY 99
Cdd:pfam19338   1 NMDQRSLPEDSLNSLIIKLIQADLLKNKTSKQMVDVKENYQSTLPKPEAPLEPDGDENAKSDFQPVISLDTELLRQQRRY 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 4505469    100 NSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRT 133
Cdd:pfam19338  81 NSPRVLLSDSTPLEPPPLYLMEDFVGNSPVGNRT 114
NGF pfam00243
Nerve growth factor family;
144-255 5.28e-74

Nerve growth factor family;


:

Pssm-ID: 459728  Cd Length: 112  Bit Score: 220.68  E-value: 5.28e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505469    144 SHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEA-RPVKNGCRGIDDKHWNSQCKTSQT 222
Cdd:pfam00243   1 SHRGEYSVCDSVSTWVTNKTTAVDIRGNEVTVLGEVKTNNGVLKQYFFETKCRAGgPGGGSGCRGIDKRHWNSYCKTKQS 80
                          90       100       110
                  ....*....|....*....|....*....|...
gi 4505469    223 YVRALTSENNKlVGWRWIRIDTSCVCALSRKIG 255
Cdd:pfam00243  81 FVRALTIDKNK-VGWRWIRIDTSCVCVLSRKSG 112
 
Name Accession Description Interval E-value
NTF3_N pfam19338
Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) ...
20-133 2.35e-78

Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) which contains two precursor homology regions located upstream of the mature NTF3 sequence. These regions play important and specific roles in the folding, processing and transport of neurotrophic factors.


Pssm-ID: 437170  Cd Length: 114  Bit Score: 231.95  E-value: 2.35e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505469     20 NMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRY 99
Cdd:pfam19338   1 NMDQRSLPEDSLNSLIIKLIQADLLKNKTSKQMVDVKENYQSTLPKPEAPLEPDGDENAKSDFQPVISLDTELLRQQRRY 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 4505469    100 NSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRT 133
Cdd:pfam19338  81 NSPRVLLSDSTPLEPPPLYLMEDFVGNSPVGNRT 114
NGF pfam00243
Nerve growth factor family;
144-255 5.28e-74

Nerve growth factor family;


Pssm-ID: 459728  Cd Length: 112  Bit Score: 220.68  E-value: 5.28e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505469    144 SHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEA-RPVKNGCRGIDDKHWNSQCKTSQT 222
Cdd:pfam00243   1 SHRGEYSVCDSVSTWVTNKTTAVDIRGNEVTVLGEVKTNNGVLKQYFFETKCRAGgPGGGSGCRGIDKRHWNSYCKTKQS 80
                          90       100       110
                  ....*....|....*....|....*....|...
gi 4505469    223 YVRALTSENNKlVGWRWIRIDTSCVCALSRKIG 255
Cdd:pfam00243  81 FVRALTIDKNK-VGWRWIRIDTSCVCVLSRKSG 112
NGF smart00140
Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of ...
144-249 6.34e-71

Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of the sympathetic and sensory nervous systems.


Pssm-ID: 128445  Cd Length: 106  Bit Score: 212.73  E-value: 6.34e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505469     144 SHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTY 223
Cdd:smart00140   1 SHRGEYSVCDSISVWVTDKTTATDISGNEVTVLGEVPVNNGPLKQYFYETRCKSPNPVKSGCRGIDSRHWNSQCKTTQTY 80
                           90       100
                   ....*....|....*....|....*.
gi 4505469     224 VRALTSENNKLVGWRWIRIDTSCVCA 249
Cdd:smart00140  81 VRALTSDANKRVGWRFIRIDTACVCV 106
 
Name Accession Description Interval E-value
NTF3_N pfam19338
Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) ...
20-133 2.35e-78

Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) which contains two precursor homology regions located upstream of the mature NTF3 sequence. These regions play important and specific roles in the folding, processing and transport of neurotrophic factors.


Pssm-ID: 437170  Cd Length: 114  Bit Score: 231.95  E-value: 2.35e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505469     20 NMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRY 99
Cdd:pfam19338   1 NMDQRSLPEDSLNSLIIKLIQADLLKNKTSKQMVDVKENYQSTLPKPEAPLEPDGDENAKSDFQPVISLDTELLRQQRRY 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 4505469    100 NSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRT 133
Cdd:pfam19338  81 NSPRVLLSDSTPLEPPPLYLMEDFVGNSPVGNRT 114
NGF pfam00243
Nerve growth factor family;
144-255 5.28e-74

Nerve growth factor family;


Pssm-ID: 459728  Cd Length: 112  Bit Score: 220.68  E-value: 5.28e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505469    144 SHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEA-RPVKNGCRGIDDKHWNSQCKTSQT 222
Cdd:pfam00243   1 SHRGEYSVCDSVSTWVTNKTTAVDIRGNEVTVLGEVKTNNGVLKQYFFETKCRAGgPGGGSGCRGIDKRHWNSYCKTKQS 80
                          90       100       110
                  ....*....|....*....|....*....|...
gi 4505469    223 YVRALTSENNKlVGWRWIRIDTSCVCALSRKIG 255
Cdd:pfam00243  81 FVRALTIDKNK-VGWRWIRIDTSCVCVLSRKSG 112
NGF smart00140
Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of ...
144-249 6.34e-71

Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of the sympathetic and sensory nervous systems.


Pssm-ID: 128445  Cd Length: 106  Bit Score: 212.73  E-value: 6.34e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505469     144 SHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTY 223
Cdd:smart00140   1 SHRGEYSVCDSISVWVTDKTTATDISGNEVTVLGEVPVNNGPLKQYFYETRCKSPNPVKSGCRGIDSRHWNSQCKTTQTY 80
                           90       100
                   ....*....|....*....|....*.
gi 4505469     224 VRALTSENNKLVGWRWIRIDTSCVCA 249
Cdd:smart00140  81 VRALTSDANKRVGWRFIRIDTACVCV 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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