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Conserved domains on  [gi|167614500|ref|NP_002277|]
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lymphocyte activation gene 3 protein isoform 1 precursor [Homo sapiens]

Protein Classification

Ig and IG_like domain-containing protein( domain architecture ID 11515198)

Ig and IG_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 267-348 8.71e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.73  E-value: 8.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167614500   267 PLTVYAGAGSRVGLPCRLPA-GVGTRSFLTAKWTPPGGGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCHIHLQEQQLNAT 345
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGsPPPEVTWYKQGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSG 80


                   ...
gi 167614500   346 VTL 348
Cdd:smart00410  81 TTL 83
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 185-252 1.25e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


:

Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 43.09  E-value: 1.25e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 167614500 185 VILNCSFSrPDRPASVHWFRNRGQGRVPVRESPHHHLAESFLFLPQVSPMDSGPWGCILTYRDGFNVS 252
Cdd:cd00096    1 VTLTCSAS-GNPPPTITWYKNGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAGGSAS 67
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 22-151 7.56e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 7.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167614500   22 PLQPGAEVPVVWAQEGAPAQlPCSPTIPLQDLSLLRRagvtwQHQPDSGPPAAAPGHPLAPGPHPAAPSSWGPRPrrytv 101
Cdd:PHA03247 2575 PRPSEPAVTSRARRPDAPPQ-SARPRAPVDDRGDPRG-----PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP----- 2643

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 167614500  102 lSVGPGGLRSGRLPLQPRVQLDERGRQRGDFSLWLRPARRADAGEYRAAV 151
Cdd:PHA03247 2644 -PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 267-348 8.71e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.73  E-value: 8.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167614500   267 PLTVYAGAGSRVGLPCRLPA-GVGTRSFLTAKWTPPGGGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCHIHLQEQQLNAT 345
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGsPPPEVTWYKQGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSG 80


                   ...
gi 167614500   346 VTL 348
Cdd:smart00410  81 TTL 83
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 263-348 1.06e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.37  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167614500  263 EPPTPLTVYAGAgsRVGLPCRLPAGVGTRSFLTaKWT--PPGGGPDLLVT--------------------GDNGDFTLRL 320
Cdd:pfam07686   1 QTPREVTVALGG--SVTLPCTYSSSMSEASTSV-YWYrqPPGKGPTFLIAyysngseegvkkgrfsgrgdPSNGDGSLTI 77

                          90       100
                  ....*....|....*....|....*....
gi 167614500  321 EDVSQAQAGTYTCHIHLQ-EQQLNATVTL 348
Cdd:pfam07686  78 QNLTLSDSGTYTCAVIPSgEGVFGKGTRL 106
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 185-252 1.25e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 43.09  E-value: 1.25e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 167614500 185 VILNCSFSrPDRPASVHWFRNRGQGRVPVRESPHHHLAESFLFLPQVSPMDSGPWGCILTYRDGFNVS 252
Cdd:cd00096    1 VTLTCSAS-GNPPPTITWYKNGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAGGSAS 67
PHA03247 PHA03247
large tegument protein UL36; Provisional
 22-151 7.56e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 7.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167614500   22 PLQPGAEVPVVWAQEGAPAQlPCSPTIPLQDLSLLRRagvtwQHQPDSGPPAAAPGHPLAPGPHPAAPSSWGPRPrrytv 101
Cdd:PHA03247 2575 PRPSEPAVTSRARRPDAPPQ-SARPRAPVDDRGDPRG-----PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP----- 2643

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 167614500  102 lSVGPGGLRSGRLPLQPRVQLDERGRQRGDFSLWLRPARRADAGEYRAAV 151
Cdd:PHA03247 2644 -PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 173-252 1.37e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 37.94  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167614500  173 ASPPGSLRASDWVILNCSFSRPDRPASVHWFRNrGQGRVPVRESPHH---HLAESFLFLPqVSPMDSGPWGCILTYRDGF 249
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSASTGSPGPDVTWSKE-GGTLIESLKVKHDngrTTQSSLLISN-VTKEDAGTYTCVVNNPGGS 79


                  ...
gi 167614500  250 NVS 252
Cdd:pfam00047  80 ATL 82
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 267-348 8.71e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.73  E-value: 8.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167614500   267 PLTVYAGAGSRVGLPCRLPA-GVGTRSFLTAKWTPPGGGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCHIHLQEQQLNAT 345
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGsPPPEVTWYKQGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASSG 80


                   ...
gi 167614500   346 VTL 348
Cdd:smart00410  81 TTL 83
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 263-348 1.06e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.37  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167614500  263 EPPTPLTVYAGAgsRVGLPCRLPAGVGTRSFLTaKWT--PPGGGPDLLVT--------------------GDNGDFTLRL 320
Cdd:pfam07686   1 QTPREVTVALGG--SVTLPCTYSSSMSEASTSV-YWYrqPPGKGPTFLIAyysngseegvkkgrfsgrgdPSNGDGSLTI 77

                          90       100
                  ....*....|....*....|....*....
gi 167614500  321 EDVSQAQAGTYTCHIHLQ-EQQLNATVTL 348
Cdd:pfam07686  78 QNLTLSDSGTYTCAVIPSgEGVFGKGTRL 106
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 185-252 1.25e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 43.09  E-value: 1.25e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 167614500 185 VILNCSFSrPDRPASVHWFRNRGQGRVPVRESPHHHLAESFLFLPQVSPMDSGPWGCILTYRDGFNVS 252
Cdd:cd00096    1 VTLTCSAS-GNPPPTITWYKNGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAGGSAS 67
PHA03247 PHA03247
large tegument protein UL36; Provisional
 22-151 7.56e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 7.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167614500   22 PLQPGAEVPVVWAQEGAPAQlPCSPTIPLQDLSLLRRagvtwQHQPDSGPPAAAPGHPLAPGPHPAAPSSWGPRPrrytv 101
Cdd:PHA03247 2575 PRPSEPAVTSRARRPDAPPQ-SARPRAPVDDRGDPRG-----PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP----- 2643

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 167614500  102 lSVGPGGLRSGRLPLQPRVQLDERGRQRGDFSLWLRPARRADAGEYRAAV 151
Cdd:PHA03247 2644 -PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 173-252 1.37e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 37.94  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167614500  173 ASPPGSLRASDWVILNCSFSRPDRPASVHWFRNrGQGRVPVRESPHH---HLAESFLFLPqVSPMDSGPWGCILTYRDGF 249
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSASTGSPGPDVTWSKE-GGTLIESLKVKHDngrTTQSSLLISN-VTKEDAGTYTCVVNNPGGS 79


                  ...
gi 167614500  250 NVS 252
Cdd:pfam00047  80 ATL 82
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 174-259 7.42e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 35.45  E-value: 7.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167614500  174 SPPGSLRASDWVILNCSFSRPDrPASVHWFRNRgqgrVPVRESPHhhlaesfLFLPQVSPMDSGPWGCILTYRDGFNVSI 253
Cdd:pfam13895   6 PSPTVVTEGEPVTLTCSAPGNP-PPSYTWYKDG----SAISSSPN-------FFTLSVSAEDSGTYTCVARNGRGGKVSN 73


                  ....*.
gi 167614500  254 MYNLTV 259
Cdd:pfam13895  74 PVELTV 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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