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isocitrate dehydrogenase [NADP], mitochondrial isoform 1 precursor [Homo sapiens]
Protein Classification
NADP-dependent isocitrate dehydrogenase ( domain architecture ID 10015366 )
NADP-dependent isocitrate dehydrogenase catalyzes the conversion of isocitrate to 2-oxoglutarate in an NADP-dependent manner
List of domain hits
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
39-451
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 867.00
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 39 YADKR IKV AK PVVE M DGDEMTRIIW QF IKEKLILP HV D IQL KY F DL GLP NRD Q TDD Q VT I D S A L A TQ K YS V AV KCATITP 118
Cdd:PTZ00435 1 NTGGK IKV KN PVVE L DGDEMTRIIW KM IKEKLILP YL D VPI KY Y DL SIE NRD K TDD K VT V D A A E A IK K HK V GI KCATITP 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 119 DEARV E EF K LKKMWKSPNGTIRNIL G GTVFREPII C KNIPRLVPGW T KPI T IGRHA H GDQYKATDFV A D RA G TFKM VFTP 198
Cdd:PTZ00435 81 DEARV K EF N LKKMWKSPNGTIRNIL D GTVFREPII I KNIPRLVPGW K KPI V IGRHA F GDQYKATDFV V D GP G KLEL VFTP 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 199 K DGS GVKEWE V YN F PA GGV G MGMYNTDESI S GFA H SCFQYA IQK K W PLY M STKNTILK A YDGRFKDIFQEI F D KH YK TD F 278
Cdd:PTZ00435 161 A DGS EPQRVD V FD F KG GGV A MGMYNTDESI E GFA R SCFQYA LDR K M PLY L STKNTILK K YDGRFKDIFQEI Y D EE YK AK F 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 279 D K NKI WYEHRLIDDMVAQ VL KS S GGFVWACKNYDGDVQSDI L AQG F GSLGLMTSVLVCPDGKT I EAEAAHGTVTRHYR E H 358
Cdd:PTZ00435 241 E K AGL WYEHRLIDDMVAQ AI KS E GGFVWACKNYDGDVQSDI V AQG Y GSLGLMTSVLVCPDGKT V EAEAAHGTVTRHYR Q H 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 359 QKG RP TSTN P IASIFAWTRGL E HR G KLD G NQ D L IR F A Q M LE KV C V ET V E S G A MTKDLA G C I HG L S N V K l NEHF LNT TD F L 438
Cdd:PTZ00435 321 QKG KE TSTN S IASIFAWTRGL A HR A KLD N NQ E L VK F C Q A LE RS C I ET I E A G F MTKDLA I C V HG S S K V T - RSDY LNT EE F I 399
410
....*....|...
gi 28178832 439 D TIKSN L DRA LG R 451
Cdd:PTZ00435 400 D KVAEK L KKK LG A 412
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
39-451
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 867.00
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 39 YADKR IKV AK PVVE M DGDEMTRIIW QF IKEKLILP HV D IQL KY F DL GLP NRD Q TDD Q VT I D S A L A TQ K YS V AV KCATITP 118
Cdd:PTZ00435 1 NTGGK IKV KN PVVE L DGDEMTRIIW KM IKEKLILP YL D VPI KY Y DL SIE NRD K TDD K VT V D A A E A IK K HK V GI KCATITP 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 119 DEARV E EF K LKKMWKSPNGTIRNIL G GTVFREPII C KNIPRLVPGW T KPI T IGRHA H GDQYKATDFV A D RA G TFKM VFTP 198
Cdd:PTZ00435 81 DEARV K EF N LKKMWKSPNGTIRNIL D GTVFREPII I KNIPRLVPGW K KPI V IGRHA F GDQYKATDFV V D GP G KLEL VFTP 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 199 K DGS GVKEWE V YN F PA GGV G MGMYNTDESI S GFA H SCFQYA IQK K W PLY M STKNTILK A YDGRFKDIFQEI F D KH YK TD F 278
Cdd:PTZ00435 161 A DGS EPQRVD V FD F KG GGV A MGMYNTDESI E GFA R SCFQYA LDR K M PLY L STKNTILK K YDGRFKDIFQEI Y D EE YK AK F 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 279 D K NKI WYEHRLIDDMVAQ VL KS S GGFVWACKNYDGDVQSDI L AQG F GSLGLMTSVLVCPDGKT I EAEAAHGTVTRHYR E H 358
Cdd:PTZ00435 241 E K AGL WYEHRLIDDMVAQ AI KS E GGFVWACKNYDGDVQSDI V AQG Y GSLGLMTSVLVCPDGKT V EAEAAHGTVTRHYR Q H 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 359 QKG RP TSTN P IASIFAWTRGL E HR G KLD G NQ D L IR F A Q M LE KV C V ET V E S G A MTKDLA G C I HG L S N V K l NEHF LNT TD F L 438
Cdd:PTZ00435 321 QKG KE TSTN S IASIFAWTRGL A HR A KLD N NQ E L VK F C Q A LE RS C I ET I E A G F MTKDLA I C V HG S S K V T - RSDY LNT EE F I 399
410
....*....|...
gi 28178832 439 D TIKSN L DRA LG R 451
Cdd:PTZ00435 400 D KVAEK L KKK LG A 412
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
42-449
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 705.87
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 42 KR IKVA K PVVEMDGDEMTRIIW QF IK E KLILP H V DIQ LKY F DLG LPN RD Q T D DQVT I D S A L A TQ KY S V A VKCATITPDEA 121
Cdd:TIGR00127 1 SK IKVA N PVVEMDGDEMTRIIW EL IK D KLILP Y V ELD LKY Y DLG VEY RD A T N DQVT V D A A E A IK KY N V G VKCATITPDEA 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 122 RVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGW T KPI T IGRHA H GDQY K ATDFV ADRA G TFKM V FT PKDG 201
Cdd:TIGR00127 81 RVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGW E KPI I IGRHA F GDQY R ATDFV VPGP G KLEL V YK PKDG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 202 SGVKEWE VY N F P - A GGV G M G MYNTDESI S GFAHS C FQ Y A IQ KKWPLY M STKNTILK A YDGRFKDIFQE IFDKH YK TD F DK 280
Cdd:TIGR00127 161 TQKVTLK VY D F E e G GGV A M A MYNTDESI E GFAHS S FQ L A LE KKWPLY L STKNTILK K YDGRFKDIFQE VYEAQ YK SK F EA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 281 NK IWYEHRLIDDMVAQ V LKS S GGF V WACKNYDGDVQSDI L AQGFGSLGLMTSVL V CPDGKT I EAEAAHGTVTRHYR EH QK 360
Cdd:TIGR00127 241 LG IWYEHRLIDDMVAQ A LKS E GGF I WACKNYDGDVQSDI V AQGFGSLGLMTSVL I CPDGKT F EAEAAHGTVTRHYR MY QK 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 361 G RP TSTN P IASIFAW T RGL E HR G KLD G N QD L IR FA QM LE KV C VE TVE S G A MTKDLA GCIH G LSNVK ln EHF LNT TD F L D T 440
Cdd:TIGR00127 321 G QE TSTN S IASIFAW S RGL A HR A KLD N N PE L SK FA NI LE SA C IN TVE A G I MTKDLA LILG G SPVER -- SAY LNT EE F I D A 398
....*....
gi 28178832 441 IKSN L DRAL 449
Cdd:TIGR00127 399 VEER L KKKI 407
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
39-447
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 533.54
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 39 YA D KRI KV - AK P - VVEMD GD ---- E M TR I IW QF I KEKLILPH --- V DI QL K YF D L G LPN RD Q T D D QVTIDS A L A TQK Y S V 109
Cdd:COG0538 8 VE D GKL KV p DN P i IPFIE GD gigp E I TR A IW KV I DAAVEKAY ggk R DI EW K EV D A G EKA RD E T G D WLPDET A E A IKE Y G V 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 110 AV K CATI TP DEA rveefklkk M W K S P N G TIR N IL GGT V F R E P I - IC K NI P RL V PGW - TKP I T I G R HAHG D Q Y KATDFV A D 187
Cdd:COG0538 88 GI K GPLT TP VGG --------- G W R S L N V TIR Q IL DLY V C R R P V r YF K GV P SP V KHP e KVD I V I F R ENTE D I Y AGIEWK A G 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 188 RAGTF K MV F TPK D GS GV kew E V YN FP AG - G V G MGMYN t DE SISGFAHSCF QYA IQ - K KWPLYMST K NT I L K AYD G R FKD I 265
Cdd:COG0538 159 SPEAL K LI F FLE D EM GV --- T V IR FP ED s G I G IKPVS - DE GTERLVRAAI QYA LD n K RKSVTLVH K GN I M K FTE G A FKD W 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 266 FQ E IFDKHYKTD F ------------- DKN KI W Y EH R LI DDM VA Q V L KSS G G - F V W A C KN YD GD VQ SD I LA QGF G S LG LMT 331
Cdd:COG0538 235 GY E VAEEEFGDK F itegpwekykgpk PAG KI V Y KD R IA DDM LQ Q I L LRP G E y D V I A T KN LN GD YI SD A LA AQV G G LG IAP 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 332 SVLVCP DG K t I E A EA A HGT VTRH yrehqk GRPT STNP IAS I FAW T RG L E HRG K L DG nqdlirf A QML EK VCVE T V ESG AM 411
Cdd:COG0538 315 GANIGD DG G - A E F EA T HGT APKY ------ AGKD STNP GSL I LSG T MM L R HRG W L EA ------- A DLI EK AVEK T I ESG KV 380
410 420 430
....*....|....*....|....*....|....*.
gi 28178832 412 T K DLA GCIH G lsnvkln EHF L N T TD F L D T I KS NLD R 447
Cdd:COG0538 381 T Y DLA RLME G ------- ATE L S T SE F G D A I IE NLD K 409
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
45-441
9.13e-92
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 281.88
E-value: 9.13e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 45 K V A KPVVEMD G D E MTRIIWQFI K EK L ILPHVDIQLKYF D L G LPNR D Q T DDQVTIDSAL A TQ K YSVAVKC A TIT P D ---- E 120
Cdd:pfam00180 1 K I A VLPGDGI G P E VMAAALKVL K AA L EKAPLEFEFEER D V G GAAI D E T GEPLPDETLE A CK K ADAVLLG A VGG P K wdpa G 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 121 A R V E EF k L KKMW K SP n G TIR N ILGGT VF R e P IICKNIPRLVPGWTK p I T I G R HAH G DQ Y KATD fvadragtfkmvf TPKD 200
Cdd:pfam00180 81 V R P E NG - L LALR K EL - G LFA N LRPAK VF P - P LGDASPLKNEVEGVD - I V I V R ELT G GI Y FGIE ------------- KGIK 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 201 GSG VK ewevynfpa GG V GMGM Y NT DE s I SGF A HSC F QY A IQK - KWPLYMST K NTI LK AY D g RFKD I FQ E IFDKH Y K tdfd 279
Cdd:pfam00180 144 GSG NE --------- VA V DTKL Y SR DE - I ERI A RVA F EL A RKR g RKKVTSVD K ANV LK SS D - LWRK I VT E VAKAE Y P ---- 208
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 280 kn KIWY EH R L I D DMVA Q VL K SSGG F - V WACK N YD GD VQ SD ILAQGF GSLGL MT S VLVCPD G k TIEA E AA HG TVTRHYREH 358
Cdd:pfam00180 209 -- DVEL EH Q L V D NAAM Q LV K NPSQ F d V IVTP N LF GD IL SD EASMLT GSLGL LP S ASLGAN G - FGIF E PV HG SAPDIAGKG 285
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 359 Q kgrpts T NPIA S I FAWTRG L EHRGK L DGN qdlirf A QML E KVCVETV ESG AM T K DLAG cihglsnvkl NEHFLN T TD F L 438
Cdd:pfam00180 286 I ------ A NPIA T I LSAAMM L RYSLG L EDA ------ A DKI E AAVLKVL ESG IR T G DLAG ---------- SATYVS T SE F G 343
...
gi 28178832 439 DTI 441
Cdd:pfam00180 344 EAV 346
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
39-451
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 867.00
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 39 YADKR IKV AK PVVE M DGDEMTRIIW QF IKEKLILP HV D IQL KY F DL GLP NRD Q TDD Q VT I D S A L A TQ K YS V AV KCATITP 118
Cdd:PTZ00435 1 NTGGK IKV KN PVVE L DGDEMTRIIW KM IKEKLILP YL D VPI KY Y DL SIE NRD K TDD K VT V D A A E A IK K HK V GI KCATITP 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 119 DEARV E EF K LKKMWKSPNGTIRNIL G GTVFREPII C KNIPRLVPGW T KPI T IGRHA H GDQYKATDFV A D RA G TFKM VFTP 198
Cdd:PTZ00435 81 DEARV K EF N LKKMWKSPNGTIRNIL D GTVFREPII I KNIPRLVPGW K KPI V IGRHA F GDQYKATDFV V D GP G KLEL VFTP 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 199 K DGS GVKEWE V YN F PA GGV G MGMYNTDESI S GFA H SCFQYA IQK K W PLY M STKNTILK A YDGRFKDIFQEI F D KH YK TD F 278
Cdd:PTZ00435 161 A DGS EPQRVD V FD F KG GGV A MGMYNTDESI E GFA R SCFQYA LDR K M PLY L STKNTILK K YDGRFKDIFQEI Y D EE YK AK F 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 279 D K NKI WYEHRLIDDMVAQ VL KS S GGFVWACKNYDGDVQSDI L AQG F GSLGLMTSVLVCPDGKT I EAEAAHGTVTRHYR E H 358
Cdd:PTZ00435 241 E K AGL WYEHRLIDDMVAQ AI KS E GGFVWACKNYDGDVQSDI V AQG Y GSLGLMTSVLVCPDGKT V EAEAAHGTVTRHYR Q H 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 359 QKG RP TSTN P IASIFAWTRGL E HR G KLD G NQ D L IR F A Q M LE KV C V ET V E S G A MTKDLA G C I HG L S N V K l NEHF LNT TD F L 438
Cdd:PTZ00435 321 QKG KE TSTN S IASIFAWTRGL A HR A KLD N NQ E L VK F C Q A LE RS C I ET I E A G F MTKDLA I C V HG S S K V T - RSDY LNT EE F I 399
410
....*....|...
gi 28178832 439 D TIKSN L DRA LG R 451
Cdd:PTZ00435 400 D KVAEK L KKK LG A 412
PRK08299
PRK08299 NADP-dependent isocitrate dehydrogenase;
42-449
0e+00
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226
Cd Length: 402
Bit Score: 844.14
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 42 KR IKV AK PVVE M DGDEMTRIIW Q FIK E KLILP HV DI Q L K Y F DLG LP NRD Q TDDQVTID S A L A TQ KY S V A VKCATITPDEA 121
Cdd:PRK08299 2 AK IKV KN PVVE L DGDEMTRIIW K FIK D KLILP YL DI D L E Y Y DLG IE NRD A TDDQVTID A A N A IK KY G V G VKCATITPDEA 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 122 RV E EF K LKKMWKSPNGTIRNILGGTVFREPIICKN I PRLVPGWTKPI T IGRHA H GDQY K ATDF VADRA G TFKM VFT PK DG 201
Cdd:PRK08299 82 RV K EF N LKKMWKSPNGTIRNILGGTVFREPIICKN V PRLVPGWTKPI V IGRHA Y GDQY R ATDF KVPGK G KLTL VFT GE DG 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 202 S g VK E W EV YN FP AG GV G MGMYN T DESI SG FA HSC F Q Y AIQK K W P L Y M STKNTILKAYDGRFKDIFQE IFDKHY K TD F DKN 281
Cdd:PRK08299 162 E - PI E H EV HD FP GA GV A MGMYN L DESI RD FA RAS F N Y GLDR K Y P V Y L STKNTILKAYDGRFKDIFQE VYEAEF K EK F EAA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 282 K I W YEHRLIDDMVA QV LK SS GG F VWACKNYDGDVQSD IL AQGFGSLGLMTSVL VC PDGKT I EAEAAHGTVTRHYR E HQKG 361
Cdd:PRK08299 241 G I T YEHRLIDDMVA SA LK WE GG Y VWACKNYDGDVQSD TV AQGFGSLGLMTSVL MT PDGKT V EAEAAHGTVTRHYR Q HQKG 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 362 RP TSTNPIASIFAWTRGL E HRGKLDGN QD L IR FA QM LEKVC V ETVESG A MTKDLA GCIHG lsnvkl NEHF L N T TD FLD T I 441
Cdd:PRK08299 321 EE TSTNPIASIFAWTRGL A HRGKLDGN PE L VK FA DT LEKVC I ETVESG F MTKDLA LLVGP ------ DQKW L T T EE FLD A I 394
....*...
gi 28178832 442 KS NL DR AL 449
Cdd:PRK08299 395 DE NL EK AL 402
PLN03065
PLN03065 isocitrate dehydrogenase (NADP+); Provisional
43-450
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 178617 [Multi-domain]
Cd Length: 483
Bit Score: 750.56
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 43 RIKV AK P V VEMDGDEMTR I IWQ F IK E KLI L P HV D IQL KYFDLG LP NRD Q TDD Q VT ID SA L AT Q KY S VA V KCATITPDEAR 122
Cdd:PLN03065 73 RIKV QN P I VEMDGDEMTR V IWQ M IK D KLI F P YL D LDI KYFDLG IL NRD A TDD K VT VE SA E AT L KY N VA I KCATITPDEAR 152
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 123 V E EF K LK K MW K SPNGTIRNIL G GTVFREPI I CKNIPRLVPGW T KPI T IGRHA H GDQY K ATD F V ADRA G TF KMVF T P K DG S 202
Cdd:PLN03065 153 V K EF G LK S MW R SPNGTIRNIL N GTVFREPI L CKNIPRLVPGW K KPI C IGRHA F GDQY R ATD T V IKGP G KL KMVF V P E DG N 232
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 203 GVK E WE VY N F PAG GV GMG MYN T DESI SG FA H S CFQY A I QKKWPLY M STKNTILK A YDGRFKDIFQE IFDKHY K TD F DKNK 282
Cdd:PLN03065 233 APV E LD VY D F KGP GV ALA MYN V DESI RA FA E S SMAM A L QKKWPLY L STKNTILK K YDGRFKDIFQE VYEEQW K QK F EEHS 312
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 283 IWYEHRLIDDMVA QVL KS S GG F VWACKNYDGDVQSD I LAQGFGSLGLMTSVL VCP DGKT I EAEAAHGTVTRH Y R E HQKG R 362
Cdd:PLN03065 313 IWYEHRLIDDMVA YAV KS E GG Y VWACKNYDGDVQSD L LAQGFGSLGLMTSVL LSS DGKT L EAEAAHGTVTRH F R L HQKG Q 392
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 363 P TSTN P IASIFAWTRGLEHR G KLD G N QD L IR F AQM LE KV C V ETVESG A MTKDLA GC IHG LSNVK ln E HF LNT TD F L D TIK 442
Cdd:PLN03065 393 E TSTN S IASIFAWTRGLEHR A KLD K N EE L LD F VHK LE SA C I ETVESG K MTKDLA IL IHG PKVSR -- E FY LNT EE F I D AVA 470
....*...
gi 28178832 443 SN L DRAL G 450
Cdd:PLN03065 471 QT L ATKR G 478
PLN00103
PLN00103 isocitrate dehydrogenase (NADP+); Provisional
40-449
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177720
Cd Length: 410
Bit Score: 718.92
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 40 A DKR IKVA K P V VEMDGDEMTR I IW QF IK E KLI L P HV D IQL KYFDLGLPNRD Q TDD Q VT ID SA L AT Q KY S VA V KCATITPD 119
Cdd:PLN00103 2 A FEK IKVA N P I VEMDGDEMTR V IW KS IK D KLI F P FL D LDI KYFDLGLPNRD A TDD K VT VE SA E AT L KY N VA I KCATITPD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 120 EARV E EF K LK K MWKSPNGTIRNIL G GTVFREPIICKNIPRLVPGWTKPI T IGRHA H GDQY K ATD F V ADRA G TF K M VF T P K 199
Cdd:PLN00103 82 EARV K EF G LK Q MWKSPNGTIRNIL N GTVFREPIICKNIPRLVPGWTKPI C IGRHA F GDQY R ATD A V IKGP G KL K L VF V P E 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 200 DGSGVK E W EVYNF P - AGGV GMG MYNTDESI SG FA HSCFQY A I QKKWPLY M STKNTILK A YDGRFKDIFQE IFDKHY K TD F 278
Cdd:PLN00103 162 GKDEKT E L EVYNF T g AGGV ALS MYNTDESI RA FA EASMNT A Y QKKWPLY L STKNTILK K YDGRFKDIFQE VYEAQW K SK F 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 279 DKNK IWYEHRLIDDMVA QV LKS S GG F VWACKNYDGDVQSD I LAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYR E H 358
Cdd:PLN00103 242 EAAG IWYEHRLIDDMVA YA LKS E GG Y VWACKNYDGDVQSD F LAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYR V H 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 359 QKG RP TSTN P IASIFAW T RGL E HR G KLDGN QD L IR F AQM LE KV CV E TVESG A MTKDLA GC IHG l SN V K l NEHF LNT TD F L 438
Cdd:PLN00103 322 QKG GE TSTN S IASIFAW S RGL A HR A KLDGN AR L LD F TEK LE AA CV G TVESG K MTKDLA LL IHG - PK V S - RDQY LNT EE F I 399
410
....*....|.
gi 28178832 439 D TIKSN L DRA L 449
Cdd:PLN00103 400 D AVAEE L KAR L 410
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
42-449
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 705.87
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 42 KR IKVA K PVVEMDGDEMTRIIW QF IK E KLILP H V DIQ LKY F DLG LPN RD Q T D DQVT I D S A L A TQ KY S V A VKCATITPDEA 121
Cdd:TIGR00127 1 SK IKVA N PVVEMDGDEMTRIIW EL IK D KLILP Y V ELD LKY Y DLG VEY RD A T N DQVT V D A A E A IK KY N V G VKCATITPDEA 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 122 RVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGW T KPI T IGRHA H GDQY K ATDFV ADRA G TFKM V FT PKDG 201
Cdd:TIGR00127 81 RVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGW E KPI I IGRHA F GDQY R ATDFV VPGP G KLEL V YK PKDG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 202 SGVKEWE VY N F P - A GGV G M G MYNTDESI S GFAHS C FQ Y A IQ KKWPLY M STKNTILK A YDGRFKDIFQE IFDKH YK TD F DK 280
Cdd:TIGR00127 161 TQKVTLK VY D F E e G GGV A M A MYNTDESI E GFAHS S FQ L A LE KKWPLY L STKNTILK K YDGRFKDIFQE VYEAQ YK SK F EA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 281 NK IWYEHRLIDDMVAQ V LKS S GGF V WACKNYDGDVQSDI L AQGFGSLGLMTSVL V CPDGKT I EAEAAHGTVTRHYR EH QK 360
Cdd:TIGR00127 241 LG IWYEHRLIDDMVAQ A LKS E GGF I WACKNYDGDVQSDI V AQGFGSLGLMTSVL I CPDGKT F EAEAAHGTVTRHYR MY QK 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 361 G RP TSTN P IASIFAW T RGL E HR G KLD G N QD L IR FA QM LE KV C VE TVE S G A MTKDLA GCIH G LSNVK ln EHF LNT TD F L D T 440
Cdd:TIGR00127 321 G QE TSTN S IASIFAW S RGL A HR A KLD N N PE L SK FA NI LE SA C IN TVE A G I MTKDLA LILG G SPVER -- SAY LNT EE F I D A 398
....*....
gi 28178832 441 IKSN L DRAL 449
Cdd:TIGR00127 399 VEER L KKKI 407
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
39-447
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 533.54
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 39 YA D KRI KV - AK P - VVEMD GD ---- E M TR I IW QF I KEKLILPH --- V DI QL K YF D L G LPN RD Q T D D QVTIDS A L A TQK Y S V 109
Cdd:COG0538 8 VE D GKL KV p DN P i IPFIE GD gigp E I TR A IW KV I DAAVEKAY ggk R DI EW K EV D A G EKA RD E T G D WLPDET A E A IKE Y G V 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 110 AV K CATI TP DEA rveefklkk M W K S P N G TIR N IL GGT V F R E P I - IC K NI P RL V PGW - TKP I T I G R HAHG D Q Y KATDFV A D 187
Cdd:COG0538 88 GI K GPLT TP VGG --------- G W R S L N V TIR Q IL DLY V C R R P V r YF K GV P SP V KHP e KVD I V I F R ENTE D I Y AGIEWK A G 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 188 RAGTF K MV F TPK D GS GV kew E V YN FP AG - G V G MGMYN t DE SISGFAHSCF QYA IQ - K KWPLYMST K NT I L K AYD G R FKD I 265
Cdd:COG0538 159 SPEAL K LI F FLE D EM GV --- T V IR FP ED s G I G IKPVS - DE GTERLVRAAI QYA LD n K RKSVTLVH K GN I M K FTE G A FKD W 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 266 FQ E IFDKHYKTD F ------------- DKN KI W Y EH R LI DDM VA Q V L KSS G G - F V W A C KN YD GD VQ SD I LA QGF G S LG LMT 331
Cdd:COG0538 235 GY E VAEEEFGDK F itegpwekykgpk PAG KI V Y KD R IA DDM LQ Q I L LRP G E y D V I A T KN LN GD YI SD A LA AQV G G LG IAP 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 332 SVLVCP DG K t I E A EA A HGT VTRH yrehqk GRPT STNP IAS I FAW T RG L E HRG K L DG nqdlirf A QML EK VCVE T V ESG AM 411
Cdd:COG0538 315 GANIGD DG G - A E F EA T HGT APKY ------ AGKD STNP GSL I LSG T MM L R HRG W L EA ------- A DLI EK AVEK T I ESG KV 380
410 420 430
....*....|....*....|....*....|....*.
gi 28178832 412 T K DLA GCIH G lsnvkln EHF L N T TD F L D T I KS NLD R 447
Cdd:COG0538 381 T Y DLA RLME G ------- ATE L S T SE F G D A I IE NLD K 409
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
45-441
9.13e-92
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 281.88
E-value: 9.13e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 45 K V A KPVVEMD G D E MTRIIWQFI K EK L ILPHVDIQLKYF D L G LPNR D Q T DDQVTIDSAL A TQ K YSVAVKC A TIT P D ---- E 120
Cdd:pfam00180 1 K I A VLPGDGI G P E VMAAALKVL K AA L EKAPLEFEFEER D V G GAAI D E T GEPLPDETLE A CK K ADAVLLG A VGG P K wdpa G 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 121 A R V E EF k L KKMW K SP n G TIR N ILGGT VF R e P IICKNIPRLVPGWTK p I T I G R HAH G DQ Y KATD fvadragtfkmvf TPKD 200
Cdd:pfam00180 81 V R P E NG - L LALR K EL - G LFA N LRPAK VF P - P LGDASPLKNEVEGVD - I V I V R ELT G GI Y FGIE ------------- KGIK 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 201 GSG VK ewevynfpa GG V GMGM Y NT DE s I SGF A HSC F QY A IQK - KWPLYMST K NTI LK AY D g RFKD I FQ E IFDKH Y K tdfd 279
Cdd:pfam00180 144 GSG NE --------- VA V DTKL Y SR DE - I ERI A RVA F EL A RKR g RKKVTSVD K ANV LK SS D - LWRK I VT E VAKAE Y P ---- 208
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 280 kn KIWY EH R L I D DMVA Q VL K SSGG F - V WACK N YD GD VQ SD ILAQGF GSLGL MT S VLVCPD G k TIEA E AA HG TVTRHYREH 358
Cdd:pfam00180 209 -- DVEL EH Q L V D NAAM Q LV K NPSQ F d V IVTP N LF GD IL SD EASMLT GSLGL LP S ASLGAN G - FGIF E PV HG SAPDIAGKG 285
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 359 Q kgrpts T NPIA S I FAWTRG L EHRGK L DGN qdlirf A QML E KVCVETV ESG AM T K DLAG cihglsnvkl NEHFLN T TD F L 438
Cdd:pfam00180 286 I ------ A NPIA T I LSAAMM L RYSLG L EDA ------ A DKI E AAVLKVL ESG IR T G DLAG ---------- SATYVS T SE F G 343
...
gi 28178832 439 DTI 441
Cdd:pfam00180 344 EAV 346
PLN00096
PLN00096 isocitrate dehydrogenase (NADP+); Provisional
50-445
7.44e-48
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177715
Cd Length: 393
Bit Score: 169.06
E-value: 7.44e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 50 V V EMD G D EMTR IIWQF I KE K L I L PHVD I - QLKY FDL GLP NRD Q T D DQV TI D SAL A TQKYSVAV K CA TITP DEAR V EEFK L 128
Cdd:PLN00096 1 M V YVA G E EMTR YTMDL I LA K W I E PHVD T s AWEF FDL RAK NRD D T E DQV LR D VIE A GARLKAIF K EP TITP TADQ V KRLG L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 129 KK M W K SPNG TI R NILG G - T VF R EP I ick N I PRLVP G WT KP ITIG RHA H G DQ Y K A TDFVADR a GT FKMV F T P KD G SG --- V 204
Cdd:PLN00096 81 KK A W G SPNG AM R RGWN G i T IS R DT I --- H I DGVEL G YK KP VFFE RHA V G GE Y S A GYKIVGK - GT LVTT F V P EE G GK piv V 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 205 KEWEVYNFPAGG V gm GMY N TDESISGF A HSC F QYAIQKKWPL Y MS TK N T IL K a YDGR F KD I FQEI FD KHY K TD F DKNKIW 284
Cdd:PLN00096 157 DDRTITDDLNAV V -- TYH N PLDNVHHL A RIF F GRCLDAGIVP Y VV TK K T VF K - WQEP F WE I MKKV FD EEF K SK F VDKGVM 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 285 YE ----- H R L I D DMVAQ - V LKSS GGF VW A CK NYDGDV QS D I LAQ GFG S L G LM TS V LV CP D -- G KT I - E A EA A HGTVT RHY 355
Cdd:PLN00096 234 KS gdelv H L L S D AATMK l V VWTD GGF GM A AH NYDGDV LT D E LAQ VHK S P G FI TS N LV GV D en G TL I k E F EA S HGTVT DMD 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 356 REHQK G RP TS T NP IASIFAWTRGLE H RGKLD G NQDLIR - F AQM L EK V CVETVES G AM T K DL A G C i H GL S nvklnehfln T 434
Cdd:PLN00096 314 EARLR G EE TS L NP LGMVEGLIGAMN H AADVH G GKERVH p F TAK L RA V IHKLFRE G RG T R DL C G A - G GL T ---------- T 382
410
....*....|.
gi 28178832 435 TD F L D TIKSN L 445
Cdd:PLN00096 383 EQ F I D AVAEE L 393
PLN00118
PLN00118 isocitrate dehydrogenase (NAD+)
251-350
2.12e-04
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062
Cd Length: 372
Bit Score: 43.33
E-value: 2.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178832 251 K NT I L K AY DG R F KDIFQ E IFD K H yktdfdk NK I W YE HRL ID DMVAQVL K SSGG F - V WACK N YD GD VQ SD IL A QGF G S LGL 329
Cdd:PLN00118 210 K AN I M K KT DG L F LKCCR E VAE K Y ------- PE I V YE EVI ID NCCMMLV K NPAL F d V LVMP N LY GD II SD LC A GLI G G LGL 282
90 100
....*....|....*....|.
gi 28178832 330 MT S VLVCPD G KTI e AEA A HG T 350
Cdd:PLN00118 283 TP S CNIGEN G LAL - AEA V HG S 302
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
