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Conserved domains on  [gi|116534898|ref|NP_001934|]
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desmoglein-2 preproprotein [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 17701714)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 163-268 1.90e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 1.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898  163 VFVGSVEELSAAHTLVMKINATDADEPNtlNSKISYRIVSlePAYPPVFYLNKDTGEIYTTSvTLDREEHSSYTLTVEAR 242
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVS--GNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*.
gi 116534898  243 DGNGevtDKPVKQAQVQIRILDVNDN 268
Cdd:cd11304    76 DGGG---PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 392-495 1.39e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 1.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898  392 VISIYVSESmdrSSKGQIIGNFQAFDEDTGLPAHARYVKLE-DRDNWISVDSVTSEIKLAKLPDFEsryvQNGTYTVKIV 470
Cdd:cd11304     1 SYEVSVPEN---APPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 116534898  471 AISEDYPRKTITGTVLINVEDINDN 495
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-155 4.33e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.49  E-value: 4.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898   62 EDLSKKNPIAKIH-SDLAEERGLKITYKYTGkgitEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVE 140
Cdd:cd11304     8 ENAPPGTVVLTVSaTDPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                          90
                  ....*....|....*
gi 116534898  141 KPLELRIKVLDINDN 155
Cdd:cd11304    84 STATVTITVLDVNDN 98
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 281-377 2.89e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 2.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898   281 VEENQ-VNVEVTRIKVFDADEigSDNWLANFTFASGNEGGYFHIETDAqtneGIVTLIKEVDYEEMKNLDFSVIVANkaa 359
Cdd:pfam00028    5 VPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATD--- 75

                           90
                   ....*....|....*...
gi 116534898   360 fhKSIRSKYKPTPIPIKV 377
Cdd:pfam00028   76 --SGGPPLSSTATVTITV 91
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 163-268 1.90e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 1.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898  163 VFVGSVEELSAAHTLVMKINATDADEPNtlNSKISYRIVSlePAYPPVFYLNKDTGEIYTTSvTLDREEHSSYTLTVEAR 242
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVS--GNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*.
gi 116534898  243 DGNGevtDKPVKQAQVQIRILDVNDN 268
Cdd:cd11304    76 DGGG---PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 182-270 1.38e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 1.38e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898    182 NATDADEPNtlNSKISYRIVSLEPayPPVFYLNKDTGEIYTTsVTLDREEHSSYTLTVEARDGNGevtDKPVKQAQVQIR 261
Cdd:smart00112    1 SATDADSGE--NGKVTYSILSGND--DGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGG---PPLSSTATVTIT 72


                    ....*....
gi 116534898    262 ILDVNDNIP 270
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
164-263 6.92e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 6.92e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898   164 FVGSVEELSAAHTLVMKINATDADEPntLNSKISYRIVSLEPayPPVFYLNKDTGEIYTTSVtLDREEHSSYTLTVEARD 243
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP--GGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATD 75

                           90       100
                   ....*....|....*....|
gi 116534898   244 GNGEVTDKPvkqAQVQIRIL 263
Cdd:pfam00028   76 SGGPPLSST---ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 392-495 1.39e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 1.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898  392 VISIYVSESmdrSSKGQIIGNFQAFDEDTGLPAHARYVKLE-DRDNWISVDSVTSEIKLAKLPDFEsryvQNGTYTVKIV 470
Cdd:cd11304     1 SYEVSVPEN---APPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 116534898  471 AISEDYPRKTITGTVLINVEDINDN 495
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 414-497 2.79e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 2.79e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898    414 QAFDEDTGLPAHARYVKL-EDRDNWISVDSVTSEIKLAKLPDFESRyvqnGTYTVKIVAISEDYPRKTITGTVLINVEDI 492
Cdd:smart00112    1 SATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 116534898    493 NDNCP 497
Cdd:smart00112   77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-155 4.33e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.49  E-value: 4.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898   62 EDLSKKNPIAKIH-SDLAEERGLKITYKYTGkgitEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVE 140
Cdd:cd11304     8 ENAPPGTVVLTVSaTDPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                          90
                  ....*....|....*
gi 116534898  141 KPLELRIKVLDINDN 155
Cdd:cd11304    84 STATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 75-157 1.45e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 1.45e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898     75 SDLAEERGLKITYKytgkGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDIND 154
Cdd:smart00112    3 TDADSGENGKVTYS----ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 116534898    155 NEP 157
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
393-490 1.66e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 1.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898   393 ISIYVSEsmdRSSKGQIIGNFQAFDEDTGLPAHARYVKLED-RDNWISVDSVTSEIKLAKLPDFESRyvqnGTYTVKIVA 471
Cdd:pfam00028    1 YSASVPE---NAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEA 73

                           90
                   ....*....|....*....
gi 116534898   472 ISEDYPRKTITGTVLINVE 490
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
281-377 2.89e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 2.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898   281 VEENQ-VNVEVTRIKVFDADEigSDNWLANFTFASGNEGGYFHIETDAqtneGIVTLIKEVDYEEMKNLDFSVIVANkaa 359
Cdd:pfam00028    5 VPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATD--- 75

                           90
                   ....*....|....*...
gi 116534898   360 fhKSIRSKYKPTPIPIKV 377
Cdd:pfam00028   76 --SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
70-150 1.92e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.91  E-value: 1.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898    70 IAKIHSDLAEERglKITYKYTGkgitEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKV 149
Cdd:pfam00028   18 VTATDPDLGPNG--RIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91


                   .
gi 116534898   150 L 150
Cdd:pfam00028   92 L 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 294-382 4.03e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.80  E-value: 4.03e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898    294 KVFDADEIgsDNWLANFTFASGNEGGYFHIETdaqtNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSirskykpTPI 373
Cdd:smart00112    1 SATDADSG--ENGKVTYSILSGNDDGLFSIDP----ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS-------STA 67


                    ....*....
gi 116534898    374 PIKVKVKNV 382
Cdd:smart00112   68 TVTITVLDV 76
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 163-268 1.90e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 1.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898  163 VFVGSVEELSAAHTLVMKINATDADEPNtlNSKISYRIVSlePAYPPVFYLNKDTGEIYTTSvTLDREEHSSYTLTVEAR 242
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVS--GNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*.
gi 116534898  243 DGNGevtDKPVKQAQVQIRILDVNDN 268
Cdd:cd11304    76 DGGG---PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 182-270 1.38e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 1.38e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898    182 NATDADEPNtlNSKISYRIVSLEPayPPVFYLNKDTGEIYTTsVTLDREEHSSYTLTVEARDGNGevtDKPVKQAQVQIR 261
Cdd:smart00112    1 SATDADSGE--NGKVTYSILSGND--DGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGG---PPLSSTATVTIT 72


                    ....*....
gi 116534898    262 ILDVNDNIP 270
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
164-263 6.92e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 6.92e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898   164 FVGSVEELSAAHTLVMKINATDADEPntLNSKISYRIVSLEPayPPVFYLNKDTGEIYTTSVtLDREEHSSYTLTVEARD 243
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP--GGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATD 75

                           90       100
                   ....*....|....*....|
gi 116534898   244 GNGEVTDKPvkqAQVQIRIL 263
Cdd:pfam00028   76 SGGPPLSST---ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 392-495 1.39e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 1.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898  392 VISIYVSESmdrSSKGQIIGNFQAFDEDTGLPAHARYVKLE-DRDNWISVDSVTSEIKLAKLPDFEsryvQNGTYTVKIV 470
Cdd:cd11304     1 SYEVSVPEN---APPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 116534898  471 AISEDYPRKTITGTVLINVEDINDN 495
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 414-497 2.79e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 2.79e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898    414 QAFDEDTGLPAHARYVKL-EDRDNWISVDSVTSEIKLAKLPDFESRyvqnGTYTVKIVAISEDYPRKTITGTVLINVEDI 492
Cdd:smart00112    1 SATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 116534898    493 NDNCP 497
Cdd:smart00112   77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-155 4.33e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.49  E-value: 4.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898   62 EDLSKKNPIAKIH-SDLAEERGLKITYKYTGkgitEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVE 140
Cdd:cd11304     8 ENAPPGTVVLTVSaTDPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                          90
                  ....*....|....*
gi 116534898  141 KPLELRIKVLDINDN 155
Cdd:cd11304    84 STATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 75-157 1.45e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 1.45e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898     75 SDLAEERGLKITYKytgkGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDIND 154
Cdd:smart00112    3 TDADSGENGKVTYS----ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 116534898    155 NEP 157
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
393-490 1.66e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 1.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898   393 ISIYVSEsmdRSSKGQIIGNFQAFDEDTGLPAHARYVKLED-RDNWISVDSVTSEIKLAKLPDFESRyvqnGTYTVKIVA 471
Cdd:pfam00028    1 YSASVPE---NAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEA 73

                           90
                   ....*....|....*....
gi 116534898   472 ISEDYPRKTITGTVLINVE 490
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
281-377 2.89e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 2.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898   281 VEENQ-VNVEVTRIKVFDADEigSDNWLANFTFASGNEGGYFHIETDAqtneGIVTLIKEVDYEEMKNLDFSVIVANkaa 359
Cdd:pfam00028    5 VPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATD--- 75

                           90
                   ....*....|....*...
gi 116534898   360 fhKSIRSKYKPTPIPIKV 377
Cdd:pfam00028   76 --SGGPPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 53-155 8.80e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 48.11  E-value: 8.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898   53 TAPVALREGEDLSKKnpIAKIHSDLAEErgLKITYKYTGKGiTEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYAL 132
Cdd:cd00031     1 IPDGSAVEGRSRGSF--RVSIPTDLIAS--SGEIIKISAAG-KEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAA 75

                          90       100
                  ....*....|....*....|...
gi 116534898  133 DARGNNVEKPLELRIKVLDINDN 155
Cdd:cd00031    76 SLGANVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
70-150 1.92e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.91  E-value: 1.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898    70 IAKIHSDLAEERglKITYKYTGkgitEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKV 149
Cdd:pfam00028   18 VTATDPDLGPNG--RIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91


                   .
gi 116534898   150 L 150
Cdd:pfam00028   92 L 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 294-382 4.03e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.80  E-value: 4.03e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116534898    294 KVFDADEIgsDNWLANFTFASGNEGGYFHIETdaqtNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSirskykpTPI 373
Cdd:smart00112    1 SATDADSG--ENGKVTYSILSGNDDGLFSIDP----ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS-------STA 67


                    ....*....
gi 116534898    374 PIKVKVKNV 382
Cdd:smart00112   68 TVTITVLDV 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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