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Conserved domains on  [gi|148539846|ref|NP_001932|]
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desmocollin-3 isoform Dsc3a preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 9.45e-34

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 214999  Cd Length: 87  Bit Score: 124.31  E-value: 9.45e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846    27 RAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADL-IRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQT 105
Cdd:smart01055   2 KPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQE 81


                   ....*.
gi 148539846   106 QKEVTV 111
Cdd:smart01055  82 KKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-351 2.08e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 2.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846 247 IYNFEVLESSRPGTTVGVVCATDRDEPdtMHTRLKYSILQQTPrsPGLFSVHPSTGVITTVSHyLDREVVDKYSLIMKVQ 326
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 148539846 327 DMDGQffGLIGTSTCIITVTDSNDN 351
Cdd:cd11304   76 DGGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-573 2.42e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 2.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846 477 YVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKL-HDPKGWITIDEISGSIITSKILDREvetpKNELYNITVLAIDKD 555
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 148539846 556 D--RSCTGTLAVNIEDVNDN 573
Cdd:cd11304   79 GppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
360-462 9.40e-15

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 9.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846  360 YEAFVEENA-FNVEILRIPIEDKDLinTANWRVNFTILKGNENGHFKISTDKetneGVLSVVKPLNYEENRQVNLEIGVN 438
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 148539846  439 NEAPFARDiprvtalNRALVTVHV 462
Cdd:pfam00028  75 DSGGPPLS-------STATVTITV 91
Cadherin pfam00028
Cadherin domain;
140-234 1.96e-13

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 1.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846  140 IPCSMQENSL-GPFPLFLQQVESDAAQNYTVFYSISGRGVDkeplNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTA 218
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 148539846  219 DGYSADLPLPLPIRVE 234
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CADH_Y-type_LIR super family cl03079
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 841-891 1.19e-07

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


The actual alignment was detected with superfamily member pfam01049:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 49.07  E-value: 1.19e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148539846  841 DRMPSQ---DYVLTYNYEGRGSPAG---SVGCCSEKQEEDgLDFLNNLEPKFITLAE 891
Cdd:pfam01049   2 DNDPSAppyDSLQTYAYEGDGSSAGslsSLESSTSDSDQD-YDYLSDWGPRFKKLAE 57
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 596-669 1.63e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 38.44  E-value: 1.63e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148539846  596 AVDPDEPVHGAPFYFSLpntSPEISRLWSLTKVND---TAARLSYQKNagfQEYTIPITVKDRAGQA--ATKLLRVNLC 669
Cdd:pfam00028  20 ATDPDLGPNGRIFYSIL---GGGPGGNFRIDPDTGdisTTKPLDRESI---GEYELTVEATDSGGPPlsSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 9.45e-34

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 124.31  E-value: 9.45e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846    27 RAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADL-IRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQT 105
Cdd:smart01055   2 KPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQE 81


                   ....*.
gi 148539846   106 QKEVTV 111
Cdd:smart01055  82 KKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-351 2.08e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 2.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846 247 IYNFEVLESSRPGTTVGVVCATDRDEPdtMHTRLKYSILQQTPrsPGLFSVHPSTGVITTVSHyLDREVVDKYSLIMKVQ 326
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 148539846 327 DMDGQffGLIGTSTCIITVTDSNDN 351
Cdd:cd11304   76 DGGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
248-346 1.42e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.42e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846  248 YNFEVLESSRPGTTVGVVCATDRDEPDtmHTRLKYSILQQTPrsPGLFSVHPSTGVITTVSHyLDREVVDKYSLIMKVQD 327
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP--NGRIFYSILGGGP--GGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATD 75

                          90
                  ....*....|....*....
gi 148539846  328 MDGQffGLIGTSTCIITVT 346
Cdd:pfam00028  76 SGGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 267-353 3.13e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 3.13e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846   267 ATDRDEPDtmHTRLKYSILQQTPrsPGLFSVHPSTGVITTVSHyLDREVVDKYSLIMKVQDMDGQffGLIGTSTCIITVT 346
Cdd:smart00112   2 ATDADSGE--NGKVTYSILSGND--DGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 148539846   347 DSNDNAP 353
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-573 2.42e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 2.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846 477 YVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKL-HDPKGWITIDEISGSIITSKILDREvetpKNELYNITVLAIDKD 555
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 148539846 556 D--RSCTGTLAVNIEDVNDN 573
Cdd:cd11304   79 GppLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 494-575 8.78e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 8.78e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846   494 KAYDP-ENRNGNgLRYKKL-HDPKGWITIDEISGSIITSKILDREvetpKNELYNITVLAIDKD--DRSCTGTLAVNIED 569
Cdd:smart00112   1 SATDAdSGENGK-VTYSILsGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGgpPLSSTATVTITVLD 75


                   ....*.
gi 148539846   570 VNDNPP 575
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
360-462 9.40e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 9.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846  360 YEAFVEENA-FNVEILRIPIEDKDLinTANWRVNFTILKGNENGHFKISTDKetneGVLSVVKPLNYEENRQVNLEIGVN 438
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 148539846  439 NEAPFARDiprvtalNRALVTVHV 462
Cdd:pfam00028  75 DSGGPPLS-------STATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 360-464 3.12e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 3.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846 360 YEAFVEENAF-NVEILRIPIEDKDLinTANWRVNFTILKGNENGHFKIstdkETNEGVLSVVKPLNYEENRQVNLEIGVN 438
Cdd:cd11304    2 YEVSVPENAPpGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*.
gi 148539846 439 NeapfaRDIPRVTAlnRALVTVHVRD 464
Cdd:cd11304   76 D-----GGGPPLSS--TATVTITVLD 94
Cadherin pfam00028
Cadherin domain;
478-568 6.92e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 6.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846  478 VRIKENLAVGSKINGYKAYDP-ENRNGNgLRYKKL-HDPKGWITIDEISGSIITSKILDREVetpkNELYNITVLAIDKD 555
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPdLGPNGR-IFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 148539846  556 --DRSCTGTLAVNIE 568
Cdd:pfam00028  78 gpPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
140-234 1.96e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 1.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846  140 IPCSMQENSL-GPFPLFLQQVESDAAQNYTVFYSISGRGVDkeplNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTA 218
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 148539846  219 DGYSADLPLPLPIRVE 234
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 159-241 8.34e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 8.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846   159 VESDAAQNYTVFYSISGRGVDkeplNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDEND 238
Cdd:smart00112   3 TDADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 148539846   239 NHP 241
Cdd:smart00112  79 NAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-239 4.60e-11

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 60.05  E-value: 4.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846 140 IPCSMQENSLGPfpLFLQQVESDAAQNYTVFYSISGRGVDKePLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTAD 219
Cdd:cd00031    2 PDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEA-LPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                         90       100
                 ....*....|....*....|
gi 148539846 220 GYSADLPLPLPIRVEDENDN 239
Cdd:cd00031   79 ANVPQTSSVFSIEVYDENDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 39-113 1.66e-09

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 55.41  E-value: 1.66e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148539846   39 VPSKLEADKIIGRVNLEECF-RSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLL 113
Cdd:pfam08758  15 VPRRLEEGQPLLNVKFNDCTgRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHGEKMASVKVTV 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 380-469 3.42e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 3.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846   380 DKDLIntANWRVNFTILKGNENGHFKIstDKETneGVLSVVKPLNYEENRQVNLEIgvnneapFARDIPRVTALNRALVT 459
Cdd:smart00112   4 DADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTV-------EATDGGGPPLSSTATVT 70

                           90
                   ....*....|
gi 148539846   460 VHVRDLDEGP 469
Cdd:smart00112  71 ITVLDVNDNA 80
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 841-891 1.19e-07

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 49.07  E-value: 1.19e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148539846  841 DRMPSQ---DYVLTYNYEGRGSPAG---SVGCCSEKQEEDgLDFLNNLEPKFITLAE 891
Cdd:pfam01049   2 DNDPSAppyDSLQTYAYEGDGSSAGslsSLESSTSDSDQD-YDYLSDWGPRFKKLAE 57
Cadherin pfam00028
Cadherin domain;
596-669 1.63e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.44  E-value: 1.63e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148539846  596 AVDPDEPVHGAPFYFSLpntSPEISRLWSLTKVND---TAARLSYQKNagfQEYTIPITVKDRAGQA--ATKLLRVNLC 669
Cdd:pfam00028  20 ATDPDLGPNGRIFYSIL---GGGPGGNFRIDPDTGdisTTKPLDRESI---GEYELTVEATDSGGPPlsSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 9.45e-34

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 124.31  E-value: 9.45e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846    27 RAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADL-IRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQT 105
Cdd:smart01055   2 KPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQE 81


                   ....*.
gi 148539846   106 QKEVTV 111
Cdd:smart01055  82 KKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-351 2.08e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 2.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846 247 IYNFEVLESSRPGTTVGVVCATDRDEPdtMHTRLKYSILQQTPrsPGLFSVHPSTGVITTVSHyLDREVVDKYSLIMKVQ 326
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 148539846 327 DMDGQffGLIGTSTCIITVTDSNDN 351
Cdd:cd11304   76 DGGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
248-346 1.42e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.42e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846  248 YNFEVLESSRPGTTVGVVCATDRDEPDtmHTRLKYSILQQTPrsPGLFSVHPSTGVITTVSHyLDREVVDKYSLIMKVQD 327
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP--NGRIFYSILGGGP--GGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATD 75

                          90
                  ....*....|....*....
gi 148539846  328 MDGQffGLIGTSTCIITVT 346
Cdd:pfam00028  76 SGGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 267-353 3.13e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 3.13e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846   267 ATDRDEPDtmHTRLKYSILQQTPrsPGLFSVHPSTGVITTVSHyLDREVVDKYSLIMKVQDMDGQffGLIGTSTCIITVT 346
Cdd:smart00112   2 ATDADSGE--NGKVTYSILSGND--DGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 148539846   347 DSNDNAP 353
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-573 2.42e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 2.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846 477 YVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKL-HDPKGWITIDEISGSIITSKILDREvetpKNELYNITVLAIDKD 555
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 148539846 556 D--RSCTGTLAVNIEDVNDN 573
Cdd:cd11304   79 GppLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 494-575 8.78e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 8.78e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846   494 KAYDP-ENRNGNgLRYKKL-HDPKGWITIDEISGSIITSKILDREvetpKNELYNITVLAIDKD--DRSCTGTLAVNIED 569
Cdd:smart00112   1 SATDAdSGENGK-VTYSILsGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGgpPLSSTATVTITVLD 75


                   ....*.
gi 148539846   570 VNDNPP 575
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
360-462 9.40e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 9.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846  360 YEAFVEENA-FNVEILRIPIEDKDLinTANWRVNFTILKGNENGHFKISTDKetneGVLSVVKPLNYEENRQVNLEIGVN 438
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 148539846  439 NEAPFARDiprvtalNRALVTVHV 462
Cdd:pfam00028  75 DSGGPPLS-------STATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 360-464 3.12e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 3.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846 360 YEAFVEENAF-NVEILRIPIEDKDLinTANWRVNFTILKGNENGHFKIstdkETNEGVLSVVKPLNYEENRQVNLEIGVN 438
Cdd:cd11304    2 YEVSVPENAPpGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*.
gi 148539846 439 NeapfaRDIPRVTAlnRALVTVHVRD 464
Cdd:cd11304   76 D-----GGGPPLSS--TATVTITVLD 94
Cadherin pfam00028
Cadherin domain;
478-568 6.92e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 6.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846  478 VRIKENLAVGSKINGYKAYDP-ENRNGNgLRYKKL-HDPKGWITIDEISGSIITSKILDREVetpkNELYNITVLAIDKD 555
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPdLGPNGR-IFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 148539846  556 --DRSCTGTLAVNIE 568
Cdd:pfam00028  78 gpPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
140-234 1.96e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 1.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846  140 IPCSMQENSL-GPFPLFLQQVESDAAQNYTVFYSISGRGVDkeplNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTA 218
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 148539846  219 DGYSADLPLPLPIRVE 234
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 159-241 8.34e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 8.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846   159 VESDAAQNYTVFYSISGRGVDkeplNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDEND 238
Cdd:smart00112   3 TDADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 148539846   239 NHP 241
Cdd:smart00112  79 NAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-239 4.60e-11

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 60.05  E-value: 4.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846 140 IPCSMQENSLGPfpLFLQQVESDAAQNYTVFYSISGRGVDKePLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTAD 219
Cdd:cd00031    2 PDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEA-LPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                         90       100
                 ....*....|....*....|
gi 148539846 220 GYSADLPLPLPIRVEDENDN 239
Cdd:cd00031   79 ANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-239 6.08e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.63  E-value: 6.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846 162 DAAQNYTVFYSIsgrgVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYAStaDGYSADL--PLPLPIRVEDENDN 239
Cdd:cd11304   25 DSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT--DGGGPPLssTATVTITVLDVNDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 39-113 1.66e-09

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 55.41  E-value: 1.66e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148539846   39 VPSKLEADKIIGRVNLEECF-RSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLL 113
Cdd:pfam08758  15 VPRRLEEGQPLLNVKFNDCTgRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHGEKMASVKVTV 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 380-469 3.42e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 3.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539846   380 DKDLIntANWRVNFTILKGNENGHFKIstDKETneGVLSVVKPLNYEENRQVNLEIgvnneapFARDIPRVTALNRALVT 459
Cdd:smart00112   4 DADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTV-------EATDGGGPPLSSTATVT 70

                           90
                   ....*....|
gi 148539846   460 VHVRDLDEGP 469
Cdd:smart00112  71 ITVLDVNDNA 80
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 841-891 1.19e-07

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 49.07  E-value: 1.19e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148539846  841 DRMPSQ---DYVLTYNYEGRGSPAG---SVGCCSEKQEEDgLDFLNNLEPKFITLAE 891
Cdd:pfam01049   2 DNDPSAppyDSLQTYAYEGDGSSAGslsSLESSTSDSDQD-YDYLSDWGPRFKKLAE 57
Cadherin pfam00028
Cadherin domain;
596-669 1.63e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.44  E-value: 1.63e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148539846  596 AVDPDEPVHGAPFYFSLpntSPEISRLWSLTKVND---TAARLSYQKNagfQEYTIPITVKDRAGQA--ATKLLRVNLC 669
Cdd:pfam00028  20 ATDPDLGPNGRIFYSIL---GGGPGGNFRIDPDTGdisTTKPLDRESI---GEYELTVEATDSGGPPlsSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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