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Conserved domains on  [gi|63054828|ref|NP_001906|]
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transmembrane ascorbate-dependent reductase CYB561 isoform 1 [Homo sapiens]

Protein Classification

Cyt_b561_CYB561 domain-containing protein( domain architecture ID 10171795)

Cyt_b561_CYB561 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 44-186 2.31e-80

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


:

Pssm-ID: 176493  Cd Length: 143  Bit Score: 237.79  E-value: 2.31e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828  44 WESDLQFNAHPLCMVIGLIFLQGNALLVYRVFRNEAKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYADLYSLHSW 123
Cdd:cd08763   1 WSGPLQFNVHPLCMVLGLVFLCGEALLVYRVFRNETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSLHSW 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 63054828 124 CGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGLKEALLFN 186
Cdd:cd08763  81 CGILTFVLYFLQWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGLTEKLLFN 143
 
Name Accession Description Interval E-value
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 44-186 2.31e-80

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 237.79  E-value: 2.31e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828  44 WESDLQFNAHPLCMVIGLIFLQGNALLVYRVFRNEAKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYADLYSLHSW 123
Cdd:cd08763   1 WSGPLQFNVHPLCMVLGLVFLCGEALLVYRVFRNETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSLHSW 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 63054828 124 CGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGLKEALLFN 186
Cdd:cd08763  81 CGILTFVLYFLQWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGLTEKLLFN 143
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 53-185 3.00e-49

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 158.54  E-value: 3.00e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828    53 HPLCMVIGLIFLQGNALLVYRV--FRNEAKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYADLYSLHSWCGILVFV 130
Cdd:pfam03188   2 HPVLMVIGFIFLMGEAILVYRVnsTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTVI 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 63054828   131 LYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGLKEALLF 185
Cdd:pfam03188  82 LYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIF 136
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 53-179 4.23e-39

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 132.36  E-value: 4.23e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828     53 HPLCMVIGLIFLQGNALLVYR-VFRNEAKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYADLYSLHSWCGILVFVL 131
Cdd:smart00665   2 HPVLMILGFGFLMGEAILVARpLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAFVL 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 63054828    132 YFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGL 179
Cdd:smart00665  82 AGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
PLN02680 PLN02680
carbon-monoxide oxygenase
 21-216 3.03e-37

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 130.69  E-value: 3.03e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828   21 QLLGLTLVAMTGAWLGLYRGGIAWESD---LQFNAHPLCMVIGLIFLQGNALLVYRVFRNeAKRTTKVLHGLLHIFALVI 97
Cdd:PLN02680  15 RLLGVIVAALVLTWTVHYRGGLALSSDnkdLIFNVHPVLMVIGLVLLNGEAMLAYKTVPG-TKNLKKLVHLTLQFLAFCL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828   98 ALVGLVAVFDYHRKKGYADLYSLHSWCGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALL 177
Cdd:PLN02680  94 SLIGVWAALKFHNEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWHVFFGIYIYALAVATATT 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 63054828  178 GLKEALLFNLGGKY-SAFEPEGVLANVLGLLLACFGGAVL 216
Cdd:PLN02680 174 GILEKATFLQSNKViSRYSTEAMLVNSLGILIVVLGGFVI 213
 
Name Accession Description Interval E-value
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 44-186 2.31e-80

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 237.79  E-value: 2.31e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828  44 WESDLQFNAHPLCMVIGLIFLQGNALLVYRVFRNEAKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYADLYSLHSW 123
Cdd:cd08763   1 WSGPLQFNVHPLCMVLGLVFLCGEALLVYRVFRNETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSLHSW 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 63054828 124 CGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGLKEALLFN 186
Cdd:cd08763  81 CGILTFVLYFLQWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGLTEKLLFN 143
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 28-235 3.68e-74

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 224.52  E-value: 3.68e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828  28 VAMTGAWLGLYRGGIAW-ESDLQFNAHPLCMVIGLIFLQGNALLVYRVFRNEAKRTTKVLHGLLHIFALVIALVGLVAVF 106
Cdd:cd08764   1 VVLVGIWLGKFRGGFSWtGPGLQFNWHPLLMVLGLIFLYGNSILVYRVFRNTRKKRLKLLHAVLHLLAFILAVIGLKAVF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828 107 DYHRKK--GYADLYSLHSWCGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGLKEALL 184
Cdd:cd08764  81 DSHNLAkpPIPNMYSLHSWLGLTAVILFSLQWVGGFVSFLFPGLPETLRAAYLPLHVFFGLFIFVLAVATALLGITEKAF 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 63054828 185 FNLgGKYSAFEPEGVLANVLGLLLACFGGAVLYILTRADWKRPSQAEEQAL 235
Cdd:cd08764 161 FSL-NKYSNLPAEGVLGNFIGIVLVIFGGLVVYLVTEPDYKRIELPEEEEL 210
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 53-185 3.00e-49

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 158.54  E-value: 3.00e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828    53 HPLCMVIGLIFLQGNALLVYRV--FRNEAKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYADLYSLHSWCGILVFV 130
Cdd:pfam03188   2 HPVLMVIGFIFLMGEAILVYRVnsTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTVI 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 63054828   131 LYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGLKEALLF 185
Cdd:pfam03188  82 LYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIF 136
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 49-179 9.97e-47

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 151.67  E-value: 9.97e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828  49 QFNAHPLCMVIGLIFLQGNALLVYRVFRNEAKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYADLYSLHSWCGILV 128
Cdd:cd08554   1 EFNWHPLLMVIGFVFLMGEALLVYRVFRLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGLAT 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 63054828 129 FVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGL 179
Cdd:cd08554  81 VLLFLLQFLSGFVLFLLPLLRLSYRSSLLPFHRFFGLAIFVLAIATILLGI 131
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 50-185 1.12e-44

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 147.07  E-value: 1.12e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828  50 FNAHPLCMVIGLIFLQGNALLVYRVFRNEaKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYADLYSLHSWCGILVF 129
Cdd:cd08766   8 FNVHPVLMVIGFIFLAGEAILAYKTVPGS-REVQKAVHLTLHLVALVLGIVGIYAAFKFHNEVGIPNLYSLHSWLGIGTI 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 63054828 130 VLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGLKEALLF 185
Cdd:cd08766  87 SLFGLQWLFGFVTFWFPGASRNTRAALLPWHVFLGLAIYYLAIATAETGLLEKLTF 142
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 18-187 1.02e-41

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176492  Cd Length: 179  Bit Score: 140.77  E-value: 1.02e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828  18 AFSQLLGLTLVAMTGAWLGLYRGGIAWE-SDLQFNAHPLCMVIGLIFLQGNALLVYRVFRN--EAKRTTKVLHGLLHIFA 94
Cdd:cd08762   2 LLLGILGIACVVLVVHWNQMWRGGFAWDgSSKNFNWHPVLMVTGMVVLYGNAALVYRIPLTwgGPKLPWKLLHAGLLLLA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828  95 LVIALVGLVAVFDYHRKKGYADLYSLHSWCGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGT 174
Cdd:cd08762  82 FILTVIGLCAVFNFHNVHHTANLYSLHSWVGICTVALFTCQWVMGFTSFLLPWAPMWLRALVKPIHVFFGAMILVLSIAS 161

                       170
                ....*....|...
gi 63054828 175 ALLGLKEALLFNL 187
Cdd:cd08762 162 CISGINEKLFFSL 174
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 53-179 4.23e-39

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 132.36  E-value: 4.23e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828     53 HPLCMVIGLIFLQGNALLVYR-VFRNEAKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYADLYSLHSWCGILVFVL 131
Cdd:smart00665   2 HPVLMILGFGFLMGEAILVARpLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAFVL 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 63054828    132 YFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGL 179
Cdd:smart00665  82 AGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
PLN02680 PLN02680
carbon-monoxide oxygenase
 21-216 3.03e-37

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 130.69  E-value: 3.03e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828   21 QLLGLTLVAMTGAWLGLYRGGIAWESD---LQFNAHPLCMVIGLIFLQGNALLVYRVFRNeAKRTTKVLHGLLHIFALVI 97
Cdd:PLN02680  15 RLLGVIVAALVLTWTVHYRGGLALSSDnkdLIFNVHPVLMVIGLVLLNGEAMLAYKTVPG-TKNLKKLVHLTLQFLAFCL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828   98 ALVGLVAVFDYHRKKGYADLYSLHSWCGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALL 177
Cdd:PLN02680  94 SLIGVWAALKFHNEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWHVFFGIYIYALAVATATT 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 63054828  178 GLKEALLFNLGGKY-SAFEPEGVLANVLGLLLACFGGAVL 216
Cdd:PLN02680 174 GILEKATFLQSNKViSRYSTEAMLVNSLGILIVVLGGFVI 213
PLN02810 PLN02810
carbon-monoxide oxygenase
 23-216 3.27e-37

carbon-monoxide oxygenase


Pssm-ID: 178406  Cd Length: 231  Bit Score: 130.71  E-value: 3.27e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828   23 LGLTLVAMTGAWLGLYRGGIAWES---DLQFNAHPLCMVIGLIFLQGNALLVYRVFRNEaKRTTKVLHGLLHIFALVIAL 99
Cdd:PLN02810  17 LAVIGAIMVLVWSIYYRGGLAWEAtnkNLIFNLHPVLMLIGLIIIGGEAIMSYKSLPLK-KEVKKLIHLVLHAIALILGI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828  100 VGLVAVFDYHRKKGYADLYSLHSWCGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGL 179
Cdd:PLN02810  96 FGICAAFKNHNESGIANLYSLHSWLGIGIISLYGIQWIYGFIVFFFPGGSTNLRSGSLPWHVLFGLFVYILAVGNAALGF 175

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 63054828  180 KEALLFNLGGKYSAFEPEGVLANVLGLLLACFGGAVL 216
Cdd:PLN02810 176 LEKLTFLESGGLDKYGSEALLVNFTAIITILYGAFVV 212
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 41-187 5.94e-35

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176495  Cd Length: 153  Bit Score: 122.31  E-value: 5.94e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828  41 GIAWE-SDLQFNAHPLCMVIGLIFLQGNALLVYRV--FRNEAKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYADL 117
Cdd:cd08765   2 GLGWDgGAAEFNWHPVLMVIGFIFIQGIAIIVYRLpwTWKCSKLLMKLIHAGLHILAFILAIISVVAVFVFHNAKNIPNM 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828 118 YSLHSWCGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGLKEALLFNL 187
Cdd:cd08765  82 YSLHSWVGLAAVILYPLQLVLGISVYLLPVAPVRLRAALMPLHVYSGLFIFGTVIATALMGITEKLIFSL 151
PLN02351 PLN02351
cytochromes b561 family protein
 17-216 5.62e-21

cytochromes b561 family protein


Pssm-ID: 215201  Cd Length: 242  Bit Score: 88.43  E-value: 5.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828   17 VAFSQLLGLTLVAMTGAWLGLYRGGIAWESDLQFNA-----HPLCMVIGLIFLQGNALLVYRVFRNeAKRTTKVLHGLLH 91
Cdd:PLN02351  13 LLFARLSGLVVAVLVLYWALFFKSSFLPQSTSQEDLvyavlHPLLMVIGFILISGEAILVHRWLPG-SRKTKKSVHLWLQ 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828   92 IFALVIALVGLVAVFDYHRKKgYADLYSLHSWCGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLS 171
Cdd:PLN02351  92 GLALASGVFGIWTKFHGQDGI-VANFYSLHSWMGLICVSLFGAQWLTGFMSFWHRGEMRTTRTTVLPWHVFLGLYTYGLA 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 63054828  172 VGTALLGLKEALLFNLGGK-YSAFEPEGVLANVLGLLLACFGGAVL 216
Cdd:PLN02351 171 VATAETGLLEKLTFLQTKRnVSKHGSESMVVNGLGLGLALLSGIVI 216
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 40-181 1.06e-13

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 67.31  E-value: 1.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828  40 GGIAWESDLQFNAHPLCMVIGLIFLQGNALLVYR---VFRNEAKRTTKVLHGLLHIFALVIALVGLVAVFDYHRKKGYAD 116
Cdd:cd08761  11 LYIARPGTSLFSWHPLLMSLGFLLLMTEALLLLQptsSLTKLARKTKVRLHWILQLLALLCILAGLVAIYYNKERNGKPH 90

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 63054828 117 LYSLHSWCGILVFVLYFVQWLVGFSFFLFPGASFSLR--SRYRPQHIFFGATIFLLSVGTALLGLKE 181
Cdd:cd08761  91 FTSWHGILGLVTVILIVLQALGGLALLYPPGLRRGESkaKKLKKYHRLSGYVAYLLGLATLVLGLET 157
Cyt_b561_FRRS1_like cd08760
Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in ...
 31-180 6.59e-10

Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176490  Cd Length: 191  Bit Score: 56.97  E-value: 6.59e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828  31 TGAWLGLYRGGIAWESDLQFNAHPLCMVIGLIFLQGNALLVYRVFRNeAKRTTKVLHGLLHIFALVIALVGLVAVFdYHR 110
Cdd:cd08760  17 GGSPFLLPNGSSVGSSDTLIKAHGVLMAIAWGILMPIGALLARYFLL-GDPVWFYLHAGLQLLAVLLAIAGFVLGI-VLV 94

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054828 111 KKGYADLYSLHSWCGILVFVLYFVQWLVGfsfFLFPGASFSLRSRYRPQHIFFGATIFLLSVGTALLGLK 180
Cdd:cd08760  95 QGGGGSLNNAHAILGIIVLALAILQPLLG---LLRPHPGSKKRSIWNWAHRWLGRAALILAIVNIFLGLD 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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